Chad Tang, Xiaohong Wang, Hendrick Soh, Steven N. Seyedin, María Angélica Cortez, Sunil Krishnan, Erminia Massarelli, David S. Hong, Aung Naing, Adi Diab, Daniel R. Gomez, Huiping Ye, John V. Heymach, Ristuko Komaki, James P. Allison, Padmanee Sharma, James W. Welsh,
Abstract With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. In this manner, clinicians hope to induce a phenomenon known as the abscopal ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2014 - American Association for Cancer Research | Cancer Immunology Research
Vivek Subbiah, Ravi Murthi, Robert M. Prins, Kyle Hendricks, Chitra Hosing, Lori Noffsinger, Mary F. McGuire, Robert Brown, Aung Naing, David S. Hong, Siqing Fu, Anthony P. Conley, Indreshpal Kaur, Sarah N. Campion, Marnix L. Bosch,
Abstract Background: Activated, autologous dendritic cells (aaDC) can be used to induce anti-tumor immune responses. A unique method of applying aaDC is through intratumoral injection, where the tumor cells serve as the source of antigen required for an adaptive anti-tumor response. A local effect may also occur as a result of cytokine production by the injected DC which makes the tumor more susceptible to a pre-existing or an induced immune attack. Methods: Forty patients with locally advanced or ...
Tópico(s): Cancer Research and Treatments
2016 - American Association for Cancer Research | Cancer Immunology Research