... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
Dandan Zhou, Ying Wang, Haifeng Hu, Huilin Liu, Jiajia Deng, Lu Li, Chunlei Zheng,
... blood vessels by regulating the expression of miRNA-613 molecule.The data of 60 HCC metastatic patients ... through Pearson correlation analysis, lncRNA MALAT1 and miRNA-613 in HCC tissues of patients with HCC were ... for the relationship between lncRNA MALAT1 and miRNA-613. The Log-growing human HCC cell strain, HepG2, ... lncR-inhibitor group), followed by knocking down miRNA-613 on the basis of knocking down lncRNA MALAT1, ... lncR/miR613-inhibitor group). The expression of miRNA-613 and lncRNA MALAT1 in each group was detected ...
Tópico(s): MicroRNA in disease regulation
2022 - BioMed Central | World Journal of Surgical Oncology
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613 Letter. From Sir T. Lascelles. To Dr. Serm ...
0000 - Gale Group | NCCO AsiaWest
Husain Yar Khan, Mandana Kamgar, Amro Aboukameel, Sahar F. Bannoura, Brian Y. Chung, Yiwei Li, Mohammed Najeeb Al Hallak, Philip A. Philip, Susan Tsai, Sanjeev Luther, William A. Hall, Asfar S. Azmi,
... control are urgently needed. We tested whether CPI-613 (devimistat), a first-in-class investigational small molecule ... of a combined treatment of RT with CPI-613 on the viability of, clonogenic potential of, and ... D assay, respectively. The synergistic effects of CPI-613-RT and chemotherapeutic agents (gemcitabine or 5-fluorouracil) ... by profiling metabolites treated with either RT, CPI-613, or both using liquid chromatography-mass spectrometry.This ... fraction RT (2 and 10 Gy) with CPI-613 significantly inhibits PDAC cell growth compared with RT ...
Tópico(s): Glioma Diagnosis and Treatment
2022 - Elsevier BV | Advances in Radiation Oncology
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
Vijay Reddy, Lakmal W. Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther, Ke Hu,
CPI-613, an inhibitor of pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) enzymes, is currently in development for ... cancer, acute myeloid leukemia, and other cancers. CPI-613 is an analog of lipoic acid, an essential ... in rats after intravenous administration of [14C]-CPI-613. CPI-613 was eliminated via oxidative metabolism followed by excretion ... was the major pathway of elimination for CPI-613. The most abundant circulating components in rat plasma ... derived from β-oxidation. In human hepatocytes, CPI-613 mainly underwent β-oxidation (M1), sulfur oxidation (M2), ...
Tópico(s): ATP Synthase and ATPases Research
2022 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613 Letter. From T. A. Campbell Eq C. B. ...
0000 - Gale Group | NCCO AsiaWest
Yonglian Huang, Hengwei Zhang, Lidong Wang, Chenxi Liu, Mingyue Guo, Hao Tan, Zhen Liu,
... roles in tumor occurrence and progression. Specifically, miR-613 participates in the regulation of tumor development in ... we investigated the expression and function of miR-613 in PTC. Methods qRT-PCR was used to determine miR-613 expression in 107 pairs of PTC and adjacent- ... mesenchymal transition (EMT) biomarkers. The effects of miR-613 on PTC progression were evaluated by performing MTS, ... also performed to validate the target of miR-613. Results In PTC, miR-613 was significantly downregulated and its low expression level ...
Tópico(s): Biomarkers in Disease Mechanisms
2021 - BioMed Central | Cancer Cell International
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
PubMed Central (PMC)
Qiying Yao, Li Zhang, Yuchuan Wang, Jun‐Li Liu, Yang Liu, Yingjie Wang,
... blot analysis. Expression patterns of UCA1 and miR-613 were assessed by quantitative real-time polymerase chain ... qRT-PCR). The relationship between UCA1 and microRNA-613 (miR-613) was verified by dual-luciferase reporter assay. We ... by DNR were reverted after UCA1 overexpression. MiR-613 was down-regulated in HL-60 and U- ... cells, and UCA1 was verified as a miR-613 sponge. MiR-613 inhibitor reversed DNR treatment-mediated effects on viability, ... 937 cells, but these impacts mediated by miR-613 inhibitor were counteracted after UCA1 inhibition. Notably, the ...
Tópico(s): RNA Research and Splicing
2021 - Portland Press | Bioscience Reports
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
IEEE Xplore
Lixia Gao, Zhigang Xu, Zheng Huang, Yan Tang, Donglin Yang, Jiuhong Huang, Leilei He, Manran Liu, Zhong‐Zhu Chen, Yong Teng,
... survival for patients with this cancer type. CPI-613 (Devimistat), a novel lipoate analog inhibiting mitochondrial metabolism, ... V-FITC/PI staining. The mechanism behind CPI-613 action was analyzed by western blot, transmission electron ... signaling pathway inhibitors or gene modifications. Results CPI-613 exhibits anticancer activity in pancreatic cancer cells by ... is identified as a vital target of CPI-613, which is inactivated in an AMPK-dependent manner and influences apoptotic process upon CPI-613. Blockade or enhancement of autophagic process does not ...
Tópico(s): Biochemical Acid Research Studies
2020 - BioMed Central | Journal of Experimental & Clinical Cancer Research
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613 Letter. From Henry Howard. To Marquess of Lansdowne. ...
0000 - Gale Group | NCCO AsiaWest
Xiangyu Su, Chanchan Gao, Xiaoyao Feng, Ming Jiang,
... regulators, which negatively regulate target gene expression. miR-613 has been revealed to be a diagnostic and ... biomarker in ESCC. However, the role of miR-613 in ESCC remains unclear. In the present study, miR-613 expression was identified to be reduced in tumor ... dehydrogenase (G6PD) as a direct target of miR-613. In contrast with miR-613, G6PD expression was increased in tumor tissues compared with matched healthy tissues. Furthermore, overexpression of miR-613 inhibited cell migration and invasion of Eca109 cells ...
Tópico(s): RNA modifications and cancer
2020 - Spandidos Publishing | Experimental and Therapeutic Medicine
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
Delong Li, Debin Meng, Rungui Niu,
... validate the extracted exosome. Cells incubated with miR-613 enriched exosomes were used to detect the function of exo-miR-613 in vitro. Then, exo-miR-613 was injected to mice treated with DDP to investigate the function role of exo-miR-613 in vivo.Comparing to BEAS-2B, the expression of miR-613 inA549 was significantly reduced, which was more obvious in A549/DDP. After incubated with exo-miR-613 and corresponding exo-negative control (NC), we found overexpression of miR-613 remarkably increased the inhibition of cell proliferation induced ...
Tópico(s): Circular RNAs in diseases
2020 - Dove Medical Press | Cancer Management and Research
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613 Letter. From Claude M. MacDonald. Walford.
0000 - Gale Group | NCCO AsiaWest
Chunhong Liu, Feng Jiang, Xueqin Zhang, Xiulong Xu,
... UCA1) in PTX resistance of BC.UCA1, microRNA-613 (miR-613) and cyclin-dependent kinase 12 (CDK12) expression was ... apoptosis in part. UCA1 negatively interacted with miR-613 and modulated PTX resistance via sponging miR-613. CDK12 was a downstream gene of miR-613 and miR-613 exerted the modulation of PTX resistance via targeting ... UCA1 regulated CDK12 level through interacting with miR-613. The regulatory role of UCA1 in PTX resistance of BC was achieved by miR-613/CDK12 axis in vivo.UCA1 mediated PTX resistance ...
Tópico(s): MicroRNA in disease regulation
2020 - Dove Medical Press | Cancer Management and Research
... Dec., 1905, Perpetual Leases, Arbitration. Vol. 9.: Volume 613
0000 - Gale Group | NCCO AsiaWest
Weiran Dai, Xiaoying Chao, Shanshan Li, Shuang Zhou, Guoqiang Zhong, Zhiyuan Jiang,
... Cx43 is one potential target gene of microRNA-613 (miR-613). Meanwhile, there is a potential target regulatory relationship between HOTAIR and miR-613. The present study is aimed at investigating whether ... expression in atrial fibrillation (AF) by sponging miR-613. The expressions of HOTAIR, miR-613, and Cx43 were detected in the right atrial ... to testify the interplay between HOTAIR and miR-613 after cotransfecting HOTAIR and miR-613. Furthermore, luciferase assays were performed to verify that ... Cx43 remolding as a ceRNA by sponging miR-613. The expression of HOTAIR and Cx43 was significantly ...
Tópico(s): Cardiac Valve Diseases and Treatments
2020 - Wiley | Cardiovascular Therapeutics