... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Fenghai Ren, Baojun Li, Chao Wang, Yanbo Wang, Binbin Cui,
... 4, 0.6 and 0.8 mCi). miR-615 expression in CRC tissues and adjacent tissues was detected by RT-qPCR. miR-615 expression was intervened with miR-615 mimic or miR-615 inhibitor, and then the CRC cells were treated ... apoptosis were measured. The methylation level of miR-615 promoter region was detected. The xenograft tumor model ... established in nude mice. The methylation of miR-615, Ki67 expression and CRC cell apoptosis were detected. ... dose-dependent manner. Compared with adjacent tissues, miR-615 expression in CRC tissues was downregulated and miR- ...
Tópico(s): Circular RNAs in diseases
2022 - BioMed Central | BMC Cancer
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang,
... we aimed to investigate the role of miR-615-3p in oxidative stress and apoptosis of human ... polymerase chain reaction was performed to determine miR-615-3p or MEF2A expression in human cardiomyocytes. Apoptosis ... by corresponding commercial kits. The binding of miR-615-3p and MEF2A in human cardiomyocytes was examined ... Hypoxia/reoxygenation treatment downregulated the expression level ofmiR-615-3p in human cardiomyocytes. Overexpressing miR-615-3p increased human cardiomyocyte viability and decreased human ...
Tópico(s): Circular RNAs in diseases
2022 - KARE Publishing | The Anatolian Journal of Cardiology
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
... involved in various cancer‑associated processes, and microRNA‑615‑5p has been identified to be decreased in ... the present study, the possible mechanism of microRNA‑615‑5p in the progression of breast cancer was ... identified as a predictive target gene of microRNA‑615‑5p using TargetScan analysis. The expression levels of microRNA‑615‑5p and its target gene, HSF1, were measured ... normal adjacent tissues. Additionally, the effects of microRNA‑615‑5p on MCF‑7 breast cancer cell growth ... examined. Furthermore, the interaction between HSF1 and microRNA‑615‑5p was investigated by a dual luciferase gene ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2021 - Spandidos Publishing | Experimental and Therapeutic Medicine
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Bo Lei, Dandan Wang, Ming Zhang, Yuwei Deng, Huijie Jiang, Yiwen Li,
... EMT) can be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor development. However, the role of miR-615-3p in the metastasis of breast cancer remains largely unknown. Methods The expression of miR-615-3p in breast cancer cells and tissues was ... PCR and situ hybridization assays. Effects of miR-615-3p on tumor metastasis were evaluated with experiments ... blot and immunofluorescence assays. Molecular mechanism of miR-615-3p in the regulation of breast cancer cell ... In the present study, we found that miR-615-3p was significantly elevated in breast cancer cells ...
Tópico(s): Cancer Cells and Metastasis
2020 - BioMed Central | Journal of Experimental & Clinical Cancer Research
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Limin Sun, Peng Wang, Zhiqiang Zhang, Kai Zhang, Zheng Xu, Siyuan Li, Junsheng Mao,
... study mainly focused on the role of miR‑615 in OS, which has not yet been reported. ... were utilized to detect the expression of miR‑615. The expression of miR‑615 and gene expression were assessed by RT‑qPCR ... used to investigate the regulatory mechanism of miR‑615 in OS. The results revealed that miR‑615 expression was reduced in OS tissues and cells, ... in OS patients. In addition, overexpression of miR‑615 restrained cell viability and metastasis in OS. Furthermore, ... was confirmed as a direct target of miR‑615. Upregulation of HK2 was detected in OS tissues. ...
Tópico(s): Circular RNAs in diseases
2020 - Spandidos Publishing | Oncology Letters
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Emma B. Laursen, Jacob Fredsøe, Linnéa Schmidt, Siri H. Strand, Helle Kristensen, Anne Rasmussen, Tina Fuglsang Daugaard, Peter Mouritzen, S. Høyer, Gitte Kristensen, Hein Vincent Stroomberg, Klaus Brasso, Martin Andreas Røder, Michael Borre, Karina D. Sørensen,
miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with nonmalignant ... investigated the clinical and biological relevance of miR-615-3p in PC. The expression of miR-615-3p was measured in PC tissue specimens from ... prostatectomy (RP), and it was investigated if miR-615-3p could predict postoperative biochemical recurrence (BCR). These ... studies conducted in PC cells (PC3M). High miR-615-3p expression was significantly associated with BCR in ... 05, log-rank test). In addition, high miR-615-3p expression was a significant predictor of PC- ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Elsevier BV | American Journal Of Pathology
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Produção Nacional
Revisado por pares
Basak Icli, Winona Wu, Denizhan Ozdemir, Hao Li, Henry S. Cheng, Stefan Haemmig, Xin Liu, Giorgio Giatsidis, Seyma Nazli Avci, Nathan Lee, Raphael Boesche Guimarães, André Manica, Júlio Flávio Meirelles Marchini, S. E. Rynning, Ivar Risnes, Ivana Hollan, Kevin Croce, Xianbin Yang, Dennis P. Orgill, Mark W. Feinberg,
... show that in response to tissue injury, microRNA-615-5p (miR-615-5p) is rapidly induced and serves as an ... synthase) signaling in vitro and in vivo. MiR-615-5p expression is increased in wounds of diabetic ... subjects with diabetes mellitus. Ectopic expression of miR-615-5p markedly inhibited endothelial cell proliferation, migration, network ... and the release of nitric oxide, whereas miR-615-5p neutralization had the opposite effects. Mechanistic studies ... small interfering RNA dependency studies demonstrate that miR-615-5p inhibits the VEGF-AKT/eNOS signaling pathway ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Jiang Shi, Huan Wang, Wanlu Feng, Siyuan Huang, Jinlu An, Yajuan Qiu, Kai Wu,
... HOXA transcript at the distal tip (HOTTIP), miR-615-3p and high mobility group box 3 (HMGB3) ... respective assay kit. The targeted correlation between miR-615-3p and HOTTIP or HMGB3 was verified using ... data revealed that HOTTIP was upregulated and miR-615-3p was downregulated in NSCLC tissues and cells. ... HOTTIP and HMGB3 mRNA levels and repressed miR-615-3p expression in NSCLC cells. HOTTIP deficiency or miR-615-3p expression restoration repressed hypoxia-induced glycolysis. Moreover, HOTTIP acted as a molecular sponge for miR-615-3p and HMGB3 was a direct target of ...
Tópico(s): RNA Research and Splicing
2019 - Elsevier BV | European Journal of Pharmacology
PubMed Central (PMC)
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Jiangtao Liu, Yanli Jia, Lijuan Jia, Tingting Li, Lei Yang, Gongwen Zhang,
... we sought to identify the regulation of miR-615-3p in NSCLC progression and its mechanism. miR-615-3p expression was significantly downregulated in NSCLC tissue ... to control normal tissue. Exogenous overexpression of miR-615-3p inhibited the growth and metastasis of NSCLC ... mouse xenograft model showed that overexpression of miR-615-3p inhibited NSCLC growth and lung metastasis, whereas decreased expression of miR-615-3p caused an opposite outcome. Furthermore, we revealed ... IGF2) expression was negatively correlated with the miR-615-3p level in NSCLC specimens, and IGF2 knockdown ...
Tópico(s): RNA modifications and cancer
2018 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
... Perpetual Leases, Arbitration. Vol. 11. Miscellaneous Documents.: Volume 615
0000 - Gale Group | NCCO AsiaWest
Yanwei Ji, Qingshan Sun, Jianbin Zhang, Haoran Hu,
MiR-615 and epidermal growth factor receptor (EGFR) are associated with a number of disease processes and pathogenesis. However, little is known about the mechanisms of miR-615 and EGFR in human glioblastoma multiforme (GBM). Here, we found that down-regulation of miR-615 expression occurred in GBM tissues and cells, and ... as EGFR expression. We further determined that miR-615 functions as a tumor suppressor by inhibiting GBM ... vivo assay validated the inhibition effect of miR-615 on tumor growth and EGFR expression. Luciferase reporter ...
Tópico(s): RNA Research and Splicing
2018 - Elsevier BV | Biochemical and Biophysical Research Communications