Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Timothy J. Wilson, Aileen C. McLeod, David M.J. Lilley,
... by the combination of the nucleobases of guanine 638 and adenine 756. This is closely similar to ... rate of cleavage resulted from changes at position 638. Replacement of this guanine by any other nucleotide ... the ribozyme. Figure 2.Sequence substitutions at position 638 in the substrate strongly impair cleavage by the ... the G638A substitution. Cleavage immediately adjacent to position 638 is enhanced in the G638A substrate relative to ... and C755. Importance of functional groups at position 638 The data presented above demonstrate that G638 plays ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2007 - Springer Nature | The EMBO Journal
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Kazuyuki Kitatani, Jolanta Idkowiak‐Baldys, Yusuf A. Hannun,
... of PKCα/βII at carboxyl-terminal sites (Thr-638/641 and Ser-657/660), whereas in MCF- ... phosphorylated at Ser-657/660 but not Thr-638/641. Inhibition of ceramide synthesis by fumonisin B1 ... only increased phosphorylation of PKCα/βII at Thr-638/641 but also restored PKCβII translocation to the ... of PKCα/βII at carboxyl-terminal sites (Thr-638/641 and Ser-657/660), whereas in MCF- ... phosphorylated at Ser-657/660 but not Thr-638/641. Inhibition of ceramide synthesis by fumonisin B1 ... only increased phosphorylation of PKCα/βII at Thr-638/641 but also restored PKCβII translocation to the ...
Tópico(s): Cellular transport and secretion
2007 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/638 Letter. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Huang Shao, Xuejun Xu, Mary-Ann A. Mastrangelo, Naijie Jing, Richard G. Cook, Glen B. Legge, David J. Tweardy,
... Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the + ... Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the + ... does not require the side chains of Glu-638, Tyr-640, and Tyr-657 or Tyr-657, ... within the peptide backbone of Stat3 at Glu-638. These findings have important implications for design of ... 2) formed by the side chains of Glu-638, Tyr-640, and Tyr-657. In the Hemmann ... domain formed by the side chains of Glu-638, Tyr-640 and Tyr-657 (A) or Tyr- ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2004 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Yi Lin, Dengju Li, Qing Liang, Shangqing Liu, Xuelan Zuo, Lin Li, Xuemei Sun, Wenxin Li, Mingxiong Guo, Zan Huang,
... regulators of hematopoiesis and leukemogenesis. We identified miR-638 as a novel regulator in myeloid differentiation and proliferation of leukemic cells. We found that miR-638 was developmentally up-regulated in cells of myeloid but not lymphoid lineage. Furthermore, significant miR-638 down-regulation was observed in primary acute myeloid leukemia (AML) blasts, whereas miR-638 expression was dramatically up-regulated in primary AML ... forced myeloid differentiation. These observations suggest that miR-638 might play a role in myeloid differentiation, and ...
Tópico(s): RNA Interference and Gene Delivery
2014 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/638 Letter.
0000 - Gale Group | NCCO EuropeAfrica
Animesh Bhattacharya, Ulf Schmitz, Yvonne Raatz, Madeleine Schönherr, Tina Kottek, Marianne Schauer, Sandra Franz, Anja Saalbach, Ulf Anderegg, Olaf Wolkenhauer, Dirk Schadendorf, Jan C. Simon, Thomas M. Magin, Julio Vera, Manfred Kunz,
... 26, 2014 Abstract The present study identified miR-638 as one of the most significantly overexpressed miRNAs ... lesions of melanomas compared with primary melanomas. miR-638 enhanced the tumorigenic properties of melanoma cells in ... identified new candidate genes including TP53INP2 as miR-638 targets, the majority of which are involved in ... of melanoma cells which was reversed by miR-638. Depletion of miR-638 stimulated expression of p53 and p53 downstream target genes and induced apoptosis and autophagy. miR-638 promoter analysis identified the miR-638 target transcription ...
Tópico(s): RNA Interference and Gene Delivery
2014 - Impact Journals LLC | Oncotarget
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Kelong Ma, Xiaorong Pan, Pingsheng Fan, Yinghua He, Jun Gu, Wei Wang, Tengyue Zhang, Zonghai Li, Xiaoying Luo,
... molecular mechanisms underlying this phenomenon are unclear. miR-638 and SRY-box 2 (SOX2) expression levels were ... validate SOX2 as a target gene of miR-638. The regulation of SOX2 expression by miR-638 was assessed using qRT-PCR and Western blot assays, and the effects of exogenous miR-638 and SOX2 on cell invasion and migration were ... SW1116 CRC cell lines. We found that miR-638 expression was differentially impaired in CRC specimens and dependent on tumor grade. The inhibition of miR-638 by an antagomiR promoted cell invasion and a ...
Tópico(s): Circular RNAs in diseases
2014 - BioMed Central | Molecular Cancer
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Jiwei Zhang, Bojian Fei, Qifeng Wang, Mingxu Song, Yuan Yin, Binbin Zhang, Shujuan Ni, Weijie Guo, Zehua Bian, Chao Quan, Zhihui Liu, Yugang Wang, Jian Yu, Xiang Du, Dong Hua, Zhaohui Huang,
... Huang, e-mail: hzhwxsy@126.com Keywords: microRNA-638, TSPAN1, cell proliferation, colorectal carcinoma, cell cycle Received: ... October 07, 2014 ABSTRACT The expression of miR-638 was found downregulated in colorectal carcinoma (CRC) in our previous study. However, the role of miR-638 in CRC remains unknown. The aim of this ... to determine the function and mechanism of miR-638 in CRC. Here, we verified that miR-638 was frequently downregulated in CRC tissues compared with ... survival analysis showed that the downregulation of miR-638 in CRC was associated with poor prognoses. The ...
Tópico(s): RNA Research and Splicing
2014 - Impact Journals LLC | Oncotarget
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Laurence Zitvogel, Guido Kroemer,
... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ... et al.Cancer Cell. 2014; 26 (this issue): 638-652Abstract Full Text Full Text PDF Scopus (602) ...
Tópico(s): RNA Interference and Gene Delivery
2014 - Cell Press | Cancer Cell
Abyssinia Expeditionary Force IOR/L/MIL/5/638
0000 - Gale Group | NCCO EuropeAfrica
Xiaohui Tan, Jin Peng, Yebo Fu, Shejuan An, Katayoon Rezaei, Sana Tabbara, Christine Teal, Yan‐Gao Man, Rachel F. Brem, Sidney W. Fu,
... been widely reported. We previously identified that miR-638 was one of the most deregulated miRNAs in breast cancer progression. Bioinformatics analysis revealed that miR-638 directly targets BRCA1. The aim of this study was to investigate the role of miR-638 in breast cancer prognosis and treatment.Formalin-fixed, ... lines were used for the functional analysis. miR-638 target genes were identified by TARGETSCAN-VERT 6.2 and miRanda. The expression of miR-638 and its target genes was analyzed by real- ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - BioMed Central | Breast Cancer Research
Abyssinia Expeditionary Force IOR/L/MIL/5/638 Government document. From H. W. Norman.
0000 - Gale Group | NCCO EuropeAfrica
Fang Wang, Jianfang Lou, Yan Cao, Xin-hui Shi, Peng Wang, Jian Xu, Erfu Xie, Ting Xu, Ruihong Sun, Jianyu Rao, Puwen Huang, Shiyang Pan, Hong Wang,
... was to investigate the clinical significance of miR-638 in the evaluation of NSCLC patient prognosis in response to chemotherapy. First, we detected miR-638 expression levels in vitro in the culture supernatants ... apoptosis rates of SPC-A1. Second, serum miR-638 expression levels were detected in vivo by using ... cisplatin treatment. In the clinic, the serum miR-638 levels of 200 cases of NSCLC patients before ... and the associations of clinicopathological features with miR-638 expression patterns after chemotherapy were analyzed. Our data ...
Tópico(s): Circular RNAs in diseases
2015 - Springer Nature | Experimental & Molecular Medicine