... Papers: Executive Council Minutes. Executive Council Decisions. Meetings 655-658: 2nd Quarter. 1938. CO 814/34-0001. ...
1938 - Gale Group | ArchivesUnbound Arabi Israeli
Hedy L. Kindler, Lawrence Garbo, John Stephenson, Jeffrey S. Wiezorek, Tony Sabin, M. Hsu, Francesca Civoli, Donald Richards,
4501 Background: AMG 655 is an investigational, fully human agonist monoclonal antibody (IgG1) that binds human death receptor 5 (DR5), activates caspases, and ... is observed when G is added to AMG 655. We performed a multi-center phase I trial to evaluate AMG 655 + G in metastatic PC pts. The primary endpoint ... Pts enrolled into sequential cohorts and received AMG 655 3 or 10 mg/kg IV days (D) ... and abdominal pain (2 pts). No anti-AMG 655 antibodies were detected. After one 3 or 10 mg/kg dose of AMG 655 after G, the C max and AUC of ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2009 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Abyssinia Expeditionary Force. IOR/L/MIL/5/655
0000 - Gale Group | NCCO EuropeAfrica
Leonard B. Saltz, Jon Infante, Lee S. Schwartzberg, John Stephenson, Caio Rocha‐Lima, Francesco Galimi, Kerry Dillingham, Meier Hsu, Jeffrey S. Wiezorek, Charles S. Fuchs,
4079 Background: AMG 655 is an investigational fully human monoclonal antibody (IgG1) agonist of human death receptor 5 (DR5). AMG 655 activates caspases and induces apoptosis in sensitive tumor ... mg/kg IV every 2 weeks) of AMG 655 that can be safely administered in combination with ... cohorts of 3- or 10-mg/kg AMG 655 + mFOLFOX6-B administered on day 1 of each ... adverse events (AE), pharmacokinetic (PK) parameters of AMG 655, and objective response rate (by modified RECIST). Results: ... 54 (37–75), median (range) time on AMG 655 treatment was 6.9 (1.6 to 11. ...
Tópico(s): HER2/EGFR in Cancer Research
2009 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Abyssinia Expeditionary Force. IOR/L/MIL/5/655 Letter. From D. S. Luceey.
0000 - Gale Group | NCCO EuropeAfrica
Luis Paz‐Ares, J.M. Sanchez Torres, Iván Díaz-Padilla, Matthew Links, Noemı́ Reguart, Michael Boyer, Jeffrey S. Wiezorek, Tony Sabin, Yang Pan, Jan P. van Meerbeeck,
e19048 Background: AMG 655 is an investigational, fully human IgG1 monoclonal agonist antibody that binds human death receptor 5 (DR5), activates caspases, and ... target dose of 15 mg/kg) of AMG 655 that can be safely administered with PC. Methods: ... were enrolled in sequential dose cohorts of AMG 655 (5 or 15 mg/kg) + P (200 mg/ ... completion/discontinuation of PC, pts may continue AMG 655 as monotherapy. Endpoints include: incidence of dose- limiting ... pts enrolled and received ≥ 1 dose of AMG 655 + PC. Ten were men; 11 had ECOG 1, ...
Tópico(s): Neuroendocrine Tumor Research Advances
2009 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
PubMed Central (PMC)
Abyssinia Expeditionary Force. IOR/L/MIL/5/655
0000 - Gale Group | NCCO EuropeAfrica
David B. Seifer, Geralyn Lambert‐Messerlian, Alan L. Schneyer,
... follicular protein.J Clin Endocrinol Metab. 2002; 87: 655-659Crossref PubMed Scopus (0) Google Scholar).Brain-derived ... follicular protein.J Clin Endocrinol Metab. 2002; 87: 655-659Crossref PubMed Scopus (0) Google Scholar). We further ... follicular protein.J Clin Endocrinol Metab. 2002; 87: 655-659Crossref PubMed Scopus (0) Google Scholar).In the ... follicular protein.J Clin Endocrinol Metab. 2002; 87: 655-659Crossref PubMed Scopus (0) Google Scholar). Follicular fluid ... follicular protein.J Clin Endocrinol Metab. 2002; 87: 655-659Crossref PubMed Scopus (0) Google Scholar). To validate ...
Tópico(s): Tendon Structure and Treatment
2003 - Elsevier BV | Fertility and Sterility
Abyssinia Expeditionary Force. IOR/L/MIL/5/655
0000 - Gale Group | NCCO EuropeAfrica
Patricia LoRusso, David S. Hong, Elisabeth I. Heath, Razelle Kurzrock, D. Wang, M. Hsu, Lovely Goyal, Jeffrey S. Wiezorek, Chris Storgard, Roy S. Herbst,
3534 Introduction: AMG 655 is a fully human monoclonal agonist antibody that binds human TRAIL receptor 2 (TR-2/DR5), activates caspases, and ... the safety, tolerability, and pharmacokinetics (PK) of AMG 655 in patients (pts) with advanced solid tumors. Methods: ... 3, 10, or 20 mg/kg) of AMG 655 administered intravenously Q2W. No AMG 655 was administered on day 43 to allow assessment ... other cohorts) had received = 1 dose of AMG 655; 12 pts were men, mean (SD) age was 53 (±8.9) years. No DLTs or AMG 655-related serious AEs were reported. The MTD was ...
Tópico(s): Cancer Research and Treatments
2007 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Abyssinia Expeditionary Force. IOR/L/MIL/5/655 Government document.
0000 - Gale Group | NCCO EuropeAfrica
... Haberman A.M. Immunity. 2007; 26 (this issue): 655-667Abstract Full Text Full Text PDF PubMed Scopus ( ... Haberman A.M. Immunity. 2007; 26 (this issue): 655-667Abstract Full Text Full Text PDF PubMed Scopus ( ... Haberman A.M. Immunity. 2007; 26 (this issue): 655-667Abstract Full Text Full Text PDF PubMed Scopus ( ... Haberman A.M. Immunity. 2007; 26 (this issue): 655-667Abstract Full Text Full Text PDF PubMed Scopus ( ... Haberman A.M. Immunity. 2007; 26 (this issue): 655-667Abstract Full Text Full Text PDF PubMed Scopus ( ...
Tópico(s): Immune Cell Function and Interaction
2007 - Cell Press | Immunity
IEEE Xplore
Abyssinia Expeditionary Force. IOR/L/MIL/5/655
0000 - Gale Group | NCCO EuropeAfrica
B. Patel, Alexandre R. Gingras, Audrey A. Bobkov, L. Miya Fujimoto, Man Zhang, Robert Liddington, Daniela Mazzeo, Jonas Emsley, Gordon C. K. Roberts, Igor Barsukov, David R. Critchley,
... region comprises a five helix bundle (residues 482-655) followed by a seven-helix bundle (656-889) ... 11, and 12). The single VBS within 482-655 is cryptic at room temperature. In contrast, talin ... 889 localized efficiently to focal adhesions, whereas 482-655 did not. Differential scanning calorimetry showed a strong ... region comprises a five helix bundle (residues 482-655) followed by a seven-helix bundle (656-889) ... 11, and 12). The single VBS within 482-655 is cryptic at room temperature. In contrast, talin ...
Tópico(s): Cellular transport and secretion
2006 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force. IOR/L/MIL/5/655 Government document.
0000 - Gale Group | NCCO EuropeAfrica
MyLinh Duong, Reshma Amin, Adrian J. Baatjes, Fiona Kritzinger, Ying Qi, Zahida Meghji, Wendy Lou, Hartmut Grasemann, Paul M. O’Byrne, Padmaja Subbarao,
... induced bronchoconstriction.Ann Allergy Asthma Immunol. 2001; 86: 655-658Abstract Full Text PDF PubMed Scopus (56) Google ... induced bronchoconstriction.Ann Allergy Asthma Immunol. 2001; 86: 655-658Abstract Full Text PDF PubMed Scopus (56) Google ... 915.08.014.916.937−35−853.054.655.059.0−32−1B611MAPH0-10.258322.038.310. ... induced bronchoconstriction.Ann Allergy Asthma Immunol. 2001; 86: 655-658Abstract Full Text PDF PubMed Scopus (56) Google ... induced bronchoconstriction.Ann Allergy Asthma Immunol. 2001; 86: 655-658Abstract Full Text PDF PubMed Scopus (56) Google ...
Tópico(s): Respiratory and Cough-Related Research
2012 - Elsevier BV | Journal of Allergy and Clinical Immunology
Abyssinia Expeditionary Force. IOR/L/MIL/5/655
0000 - Gale Group | NCCO EuropeAfrica
Munetaka Kunishima, Kanako Kikuchi, Yukio Kawai, Kazuhito Hioki,
... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan)Faculty of Pharmaceutical Sciences, Institute of ... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan)Search for more papers by this ... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan)Search for more papers by this ... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan) Cooperative Research Center of Life Sciences, ... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan)Search for more papers by this ... University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586 (Japan)Faculty of Pharmaceutical Sciences, Institute of ...
Tópico(s): Supramolecular Chemistry and Complexes
2012 - Wiley | Angewandte Chemie International Edition
Abyssinia Expeditionary Force. IOR/L/MIL/5/655 Government document.
0000 - Gale Group | NCCO EuropeAfrica
John Atack, Luanda Alder, S. D. Cook, Andrew Smith, Ruth M. McKernan,
L-655,708 is an imidazobenzodiazepine possessing 30-70-fold selectivity for the benzodiazepine binding site of GABA(A) ... subunit. In the present study, [(3)H]L-655,708 was used to label mouse brain benzodiazepine ... pharmacology of mouse in vivo [(3)H]L-655,708 binding was consistent with selective in vivo ... equipotent at inhibiting in vivo [(3)H]L-655,708 and [(3)H]Ro 15-1788 binding; ... no inhibition of in vivo [(3)H]L-655,708 binding despite inhibiting in vivo [(3)H]Ro 15-1788 binding; and L-655,708 was more potent at inhibiting the in ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2005 - Elsevier BV | Neuropharmacology