Austin J. Yang, Dhusdee Chandswangbhuvana, Theo Shu, Agnes Henschen, Charles Glabe,
... Natl. Acad. Sci. U. S. A. 1994; 91: 8378-8382Crossref PubMed Scopus (370) Google Scholar, 27Saido T. ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
1999 - Elsevier BV | Journal of Biological Chemistry
Beth E. Mileson, Lisa Sweeney, Michael L. Gargas, John H. Kinzell,
Iodomethane is a new pre-plant soil fumigant approved in the United States. Human exposure may occur via inhalation due to the high vapor pressure of iodomethane. A quantitative human health risk assessment was conducted for inhalation exposure. The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained ...
Tópico(s): Air Quality and Health Impacts
2009 - Taylor & Francis | Inhalation Toxicology
Christopher R. Kirman, Lisa Sweeney, Michael L. Gargas, John H. Kinzell,
Recent studies have indicated that exposures to methyl iodide (MeI) produce a number of effects in laboratory animals, including fetal toxicity, neurotoxicity, and degeneration of the nasal epithelium. An understanding of the mode of action by which the effects of MeI are produced is useful in guiding critical decisions used in risk assessment. These decisions include the selection of the appropriate internal dose measure(s) calculated using physiologically based pharmacokinetic (PBPK) modeling, and ...
Tópico(s): Retinoids in leukemia and cellular processes
2008 - Taylor & Francis | Inhalation Toxicology
Lisa Sweeney, Christopher R. Kirman, Shawn A. Gannon, Karla D. Thrall, Michael L. Gargas, John H. Kinzell,
Methyl iodide (MeI) has been proposed as an alternative to methyl bromide as a pre-plant soil fumigant that does not deplete stratospheric ozone. In inhalation toxicity studies performed in animals as part of the registration process, three effects have been identified that warrant consideration in developing toxicity reference values for human risk assessment: nasal lesions (rat), acute neurotoxicity (rat), and fetal loss (rabbit). Uncertainties in the risk assessment can be reduced by using an internal ...
Tópico(s): Poisoning and overdose treatments
2009 - Taylor & Francis | Inhalation Toxicology
Lisa Sweeney, S. Prues, James E. Reboulet,
Two studies were conducted to assess the potential airway and immune effects following subacute (14 d) exposure of female rats to 500, 1000 or 2000 mg/m3 of Jet-A for 4 h/d. The first study used Sprague-Dawley rats; the second study included both Fischer 344 (F344) and Sprague-Dawley rats. In the first study, exposure to 2000 mg/m3 jet fuel may have caused significant upper airway inflammation on day 7 post-exposure, as indicated by elevated protein and lactate dehydrogenase in nasal lavage fluid, ...
Tópico(s): Toxic Organic Pollutants Impact
2013 - Taylor & Francis | Inhalation Toxicology
... onstage, and (in a production of Sondheim’s Sweeney Todd) having lead roles simultaneously characterized by two ...
Tópico(s): Interpreting and Communication in Healthcare
2018 - Johns Hopkins University Press | Theatre topics
... national identity really suffered for it” (74). Susan Sweeney is the only voice practitioner in the book ... admission in the current backlash against Skinner, but Sweeney also defines it as only one of many ...
Tópico(s): Diverse Musicological Studies
2013 - Johns Hopkins University Press | Theatre topics
Daniel J. Hardt, R. Arden James, Chester P. Gut, Shawn M. McInturf, Lisa Sweeney, Richard P. Erickson, Michael L. Gargas,
The inhalation toxicity of submarine contaminants is of concern to ensure the health of men and women aboard submarines during operational deployments. Due to a lack of adequate prior studies, potential general, neurobehavioral, reproductive and developmental toxicity was evaluated in male and female rats exposed to mixtures of three critical submarine atmospheric components: carbon monoxide (CO) and carbon dioxide (CO2; levels elevated above ambient), and oxygen (O2; levels decreased below ambient). ...
Tópico(s): Climate Change and Health Impacts
2015 - Taylor & Francis | Inhalation Toxicology
Daniel J. Hardt, R. Arden James, Chester P. Gut, Shawn M. McInturf, Lisa Sweeney, Richard P. Erickson, Michael L. Gargas,
Carbon monoxide (CO), carbon dioxide (CO2) and low-level oxygen (O2) (hypoxia) are submarine atmosphere components of highest concern because of a lack of toxicological data available to address the potential effects from long-duration, combined exposures on female reproductive and developmental health. In this study, subchronic toxicity of mixed atmospheres of these three submarine air components was evaluated in rats. Male and female rats were exposed via inhalation to clean air (0.4 ppm CO; 0.13% ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2015 - Taylor & Francis | Inhalation Toxicology
... Story, The Last Days of Judas Iscariot, and Sweeney Todd: The Demon Barber of Fleet Street—and ...
Tópico(s): Organizational Learning and Leadership
2012 - Johns Hopkins University Press | Theatre topics