CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
... GC cells under hypoxia (1% O2). CircC6orf132, microRNA-873-5p (miR-873-5p), and protein kinase AMP-activated alpha 1 ... were reversed by silencing circC6orf132. CircC6orf132 targeted miR-873-5p; and the inhibition of circC6orf132 knockdown for ... hypoxia on GC cells was abrogated by miR-873-5p inhibitor. PRKAA1 was validated as a downstream gene of miR-873-5p, and miR-873-5p functioned as an anticancer molecule in GC ... level. CircC6orf132 could regulate PRKAA1 by sponging miR-873-5p. CircC6orf132/miR-873-5p/PRKAA1 axis could ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Frontiers Media | Frontiers in Genetics
CO 873, 15 Aug. /04 Minutes.
0000 - Gale Group | NCCO EuropeAfrica
Yuhao Zou, Chenming Zhong, Zekai Hu, Shiwei Duan,
miR-873 is a microRNA located on chromosome 9p21.1. miR-873-5p and miR-873-3p are the two main members of the miR-873 family. Most studies focus on miR-873-5p, and there are a few studies on miR-873-3p. The expression level of miR-873-5p was down-regulated in 14 cancers and up-regulated in 4 cancers. miR-873-5p has many targeted genes, which have unique ... as catalytic activity, transcription regulation, and binding. miR-873-5p affects cancer development through the PIK3/AKT/ ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Frontiers Media | Frontiers in Oncology
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Xiao‐Li Yang, Yu‐Shui Ma, Yushan Liu, Xiaohui Jiang, Hua Ding, Yi Shi, Chengyou Jia, Gai‐Xia Lu, Dandan Zhang, Huimin Wang, Pei‐Yao Wang, Zhongwei Lv, Fei Yu, Ji‐Bin Liu, Da Fu,
... aimed to investigate the functional role of miR-873 and its associated mechanism to unravel the biological ... expression patterns of pleckstrin-2 (PLEK2) and miR-873 were detected in the pancreatic cancer tissues. Then to further investigate specific role of miR-873, the pancreatic cancer stem cells were treated with miR-873 mimic, PLEK2, small interfering RNA against PLEK2, LY294002 ( ... Pancreatic cancer tissues exhibited a decline of miR-873 expression and an enhancement of PLEK2 expression. miR-873 targeted PLEK2 and downregulated its expression, leading to ...
Tópico(s): RNA modifications and cancer
2021 - Elsevier BV | Cellular Signalling
PubMed Central (PMC)
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Qianqian Guo, Ting Wang, Yue Yang, Lanlan Gao, Qiong Zhao, Wenzhou Zhang, Tao Xi, Lufeng Zheng,
... exhibited the opposite effects. Mechanistically, YY1 decreased microRNA-873-5p (miR-873-5p) level by recruiting histone deacetylase 4 (HDAC4) and HDAC9 to miR-873-5p promoter and thus increasing the deacetylation level of miR-873-5p promoter. Sequentially, YY1 activated the downstream PI3K/ ... have been confirmed to be suppressed by miR-873-5p in our recent work. Moreover, the suppressed effect of YY1/miR-873-5p axis on the stemness of breast cancer ... Finally, it was found that the YY1/miR-873-5p axis is involved in the chemoresistance of ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Cell Press | Molecular Therapy — Nucleic Acids
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Zhenglin Wang, Wei Liu, Cong Wang, Zhi-Long Ai,
... was to investigate the biological functions of miR-873-5p and its underlying molecular mechanisms in PTC. ... RT-qPCR) analysis was performed to detect miR-873-5p expressions in PTC tissues and cell lines. The target gene of miR-873-5p was predicted by TargetScan and confirmed by ... by Western blot. Results: We found that miR-873-5p expression was downregulated in PTC tissues and ... CXCL16 was identified as a target of miR-873-5p, and its expression was upregulated in PTC ... mRNA and protein levels. Functionally, overexpression of miR-873-5p inhibited PTC cell proliferation, migration and invasion, ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2020 - Dove Medical Press | OncoTargets and Therapy
OAPEN Free
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Gangyue Wang, Yi Dong, Heng Liu, Nan Ji, Jilei Cao, Aihui Liu, Xin Tang, Yu Ren,
... development of chemoresistance; however, the role of miR-873 in the chemoresistance of breast cancer and its ... the present study demonstrated that overexpression of miR-873 sensitized triple-negative breast cancer (TNBC) cells (MDA- ... BT549) towards gemcitabine treatment, while inhibition of miR-873 promoted resistance of TNBC cells to gemcitabine exposure. ... was predicted as a candidate target of miR-873, and the regulatory association between ZEB1 and miR-873 was validated with a dual luciferase assay. Reverse ...
Tópico(s): FOXO transcription factor regulation
2019 - Spandidos Publishing | Oncology Letters
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Yufeng Zhu, Xiaojian Zhang, Ming Qi, Yong Zhang, Feng Ding,
... TUSC3 in colon cancer remained unclear. Methods MiR‐873‐5p was predicted and identified as the regulator ... and luciferase reporter assays. The roles of miR‐873‐5p in regulating colon cancer cell proliferation, colony ... were performed to investigate the effects of miR‐873‐5p on proliferation and lung metastasis. Moreover, the miR‐873‐5p/TUSC3 related signaling pathway and the prognostic value of combining miR‐873‐5p and TUSC3 for colon cancer patients were also explored. Results Here, we identified miR‐873‐5p as a novel regulator of TUSC3 in ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Wiley | Journal of Gastroenterology and Hepatology
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Pablo Fernández‐Tussy, David Fernández‐Ramos, Fernando Lopitz‐Otsoa, Jorge Simón, Lucía Barbier‐Torres, Beatriz Gómez‐Santos, Maitane Núñez-García, Mikel Azkargorta, Virginia Gutiérrez‐de Juan, Marina Serrano‐Maciá, Rubén Rodríguez‐Agudo, Paula Iruzubieta, Juan Anguíta, Rui E. Castro, Devin Champagne, Mercedes Rincón, Félix Elortza, Anita Arslanow, Marcin Krawczyk, Frank Lammert, Mélanie Kirchmeyer, Iris Behrmann, Javier Crespo, Shelly C. Lu, José M. Mato, Marta Varela‐Rey, Patricia Aspichueta, Teresa C. Delgado, María Luz Martínez‐Chantar,
... in GNMT downregulation by its repressor microRNA miR-873-5p and the metabolic pathways affected in NAFLD ... as the benefit of recovery GNMT expression.miR-873-5p and GNMT expression were evaluated in liver ... NAFLD murine models were used to assess miR-873-5p/GNMT involvement in fatty liver progression through targeting of the miR-873-5p as NAFLD therapy.We describe a new ... In NAFLD, GNMT expression is controlled by miR-873-5p in the hepatocytes, leading to disruptions in ... non-alcoholic steatohepatitis (NASH) model. Upregulation of miR-873-5p is shown in the liver of NAFLD/ ...
Tópico(s): Liver Disease and Transplantation
2019 - Elsevier BV | Molecular Metabolism
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
... be crucial for identifying successful therapeutic techniques. miR‑873 has been demonstrated to be dysregulated in different ... the expression status and regulatory roles of miR‑873 are yet to be elucidated in EC. In ... quantitative PCR was carried out to detect miR‑873 expression in EC tissues and cell lines. Cell ... were utilized to determine the influence of miR‑873 on the proliferation and invasion of EC cells. miR‑873 expression was revealed to be downregulated in EC tissues and cell lines. Decreased miR‑873 expression was significantly associated with International Federation of ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Spandidos Publishing | Experimental and Therapeutic Medicine
CO 873, 15 Aug. /04
0000 - Gale Group | NCCO EuropeAfrica
Yilin Liu, Yuqiang Wang, Hao Yang, Liang Zhao, Ruipeng Song, Hongyu Tan, Limin Wang,
... therapeutic targets. Previous studies have shown that miR‑873 plays tumor suppressive or oncogenic roles in different types of cancer. However, whether miR‑873 is implicated in OS carcinogenesis and cancer progression ... the present study, we demonstrated that the miR‑873 levels were decreased in OS tissues and cell lines. The decreased expression of miR‑873 was related to tumor size, clinical stage and ... in patients with OS. The introduction of miR‑873 significantly inhibited tumor cell proliferation, migration and invasion ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2019 - Spandidos Publishing | International Journal of Oncology