CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
... in IS with the involvement of microRNA (miR)-874-3p/interleukin (IL) 1B.MIAT, miR-874-3p and IL1B levels in serum of patients ... MCAO mice were injected with Agomir of miR-874-3p, shRNA or overexpression vector of MIAT or ... measured. The targeting relationship between MIAT and miR-874-3p, as well as that between miR-874-3p and IL1B was explored.In patients with ... MIAT and IL1B were up-regulated and miR-874-3p was down-regulated. MIAT absorbed miR-874-3p while miR-874-3p targeted IL1B. Silencing of MIAT or IL1B, ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
1985 - Elsevier BV | Automatica
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa Telegrams Relating to Affairs in South Africa. Monograph. Colonial Office.
0000 - Gale Group | NCCO EuropeAfrica
Timothy R. Vollmer, Daniel Wynn, Mohammed Shamsul Alam, Joaquin Valdes,
... study assessed the efficacy and safety of ABT-874, a monoclonal anti-IL-12/23 antibody, in ... study, patients with RRMS or SPMS received ABT-874 200 mg every other week (EOW), ABT-874 200 mg every week (EW), or placebo. The ... were measured. Results: 215 patients were randomized (ABT-874 200 mg EOW, N = 76; ABT-874 200 mg EW, N = 70; placebo, N = 69). ... enhanced lesions were statistically significantly reduced with ABT-874 200 mg EOW vs. placebo (mean number [SD]: ... 4], p = 0.003), but not with ABT-874 200 mg EW (6.8 [11.3], p = ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2010 - SAGE Publishing | Multiple Sclerosis Journal
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Nijiro Nohata, Toyoyuki Hanazawa, Naoko Kikkawa, Daiju Sakurai, Lisa Fujimura, Takeshi Chiyomaru, Kazumori Kawakami, Hirofumi Yoshino, Hideki Enokida, Masayuki Nakagawa, Akihiro Katayama, Yasuaki Harabuchi, Yoshitaka Okamoto, Naohiko Seki,
... squamous cell carcinoma (MSSCC), we found that miR-874 was significantly reduced in cancer cells. We focused on the functional significance of miR-874 in cancer cells and identification of miR-874-regulated novel cancer networks in MSSCC.We used ... significantly reduced in cancer cells, such as miR-874, miR-133a, miR-375, miR-204, and miR-1. We focused on miR-874 as the most downregulated novel miRNA in our ... and invasion. A molecular target search of miR-874 revealed that PPP1CA was directly regulated by miR- ...
Tópico(s): interferon and immune responses
2011 - Springer Nature | British Journal of Cancer
PubMed Central (PMC)
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Yen Hsieh, Li‐Po Lee, Nai‐Jen Hou, Shinn‐Cherng Chen, Zu‐Yau Lin, Ming‐Yuh Hsieh, Liang‐Yen Wang, Jun-Fa Tsai, Wen‐Yu Chang, Ming‐Lung Yu,
A T-to-A polymorphic sequence at position +874 in the interferon (IFN)–gamma gene (+874 IFN–gamma) might be associated with disease susceptibilities. To investigate the influence of +874 IFN–gamma polymorphism on the hepatitis C virus ( ... PCR-SSP) approach. The distribution of genotypes for +874 IFN–gamma were T/T: 12 (4.0%), ... 0.028). Patients with the T allele of +874 IFN–gamma had a significantly higher rate of ... By multivariate logistic regression analyses, T allele of +874 IFN–gamma and age were independent factors associated ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2006 - Elsevier BV | Translational research
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Don X. Nguyen, Laurel A. Baglia, Shih-Min A. Huang, Christina M. Baker, Dennis J. McCance,
... the pRb.RR mutant, in which lysines 873/874 in the C terminus have been mutated to ... of pRb in vitro at lysine residues 873/874 (Chan et al, 2001). As our results demonstrate ... in cells, we reasoned that amino acids 873/874 of pRb might be targeted by P/CAF ... well. To verify this hypothesis, lysine residues 873/874 of pRb were mutated to arginine (RR), a ... sites. Nevertheless, we conclude that lysine residues 873/874 are important sites of pRb acetylation. pRb acetylation ... 4.Acetylation of pRb at lysine residues 873/874 is required for permanent cell cycle withdrawal. (A) ...
Tópico(s): Ubiquitin and proteasome pathways
2004 - Springer Nature | The EMBO Journal
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Divya Kesanakurti, Dilip Rajasekhar Maddirela, Subramanyam Chittivelu, Jasti S. Rao, Chandramu Chetty,
... disorders including cancer. Here we show that miR-874 plays a tumor suppressor role in non-small ... uPA as the putative target genes of miR-874. Our preliminary in situ hybridization experiments demonstrated the diminution of miR-874 expression in lung cancer tissues compared to their normal counter parts. Overexpression of miR-874 in CD133-positive cancer stem cell (CSC) population ... differentiation into epithelial-like cells. Restoration of miR-874 expression drastically reduced cell invading ability in comparison ...
Tópico(s): Cancer-related molecular mechanisms research
2013 - Elsevier BV | Biochemical and Biophysical Research Communications
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Kai Wang, Fang Liu, Lu‐Yu Zhou, S-L Ding, Bo Long, Cui-Yun Liu, Tao Sun, Y-Y Fan, Lei Sun, P-F Li,
... H2O2 treatment, and the results showed that miR-874 was substantially increased. We further studied the function of miR-874, and observed that knockdown of miR-874 attenuated necrosis in the cellular model and also ... We searched for the downstream mediator of miR-874 and identified that caspase-8 was a target of miR-874. Caspase-8 was able to antagonize necrosis. When suppressed by miR-874, caspase-8 lost the ability to repress necrotic ... In exploring the molecular mechanism by which miR-874 expression is regulated, we identified that Foxo3a could ...
Tópico(s): Circular RNAs in diseases
2013 - Springer Nature | Cell Death and Disease
IntechOpen
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Nijiro Nohata, Toyoyuki Hanazawa, Takashi Kinoshita, Ayako Inamine, Naoko Kikkawa, Toshihiko Itesako, Hirofumi Yoshino, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki,
... of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell ... was to investigate the functional significance of miR-874 in cancer cells and to identify novel miR-874-mediated cancer pathways and responsible genes in head ... HNSCC). Gain-of-function studies using mature miR-874 were performed to investigate cell proliferation and cell ... cell lines (SAS and FaDu). To identify miR-874-mediated molecular pathways and targets, we utilised gene ...
Tópico(s): Cancer-related molecular mechanisms research
2013 - Springer Nature | British Journal of Cancer
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
Hiroshi Inoue, Jian Li, Masayuki Honda, Hideaki Nakashima, Kenji Shibuta, Shinya Arinaga, Hiroaki Ueo, Masaki Mori, Tsuyoshi Akiyoshi,
... Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874, JapanSearch for more papers by this authorJian Li, ... Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874, JapanSearch for more papers by this authorMasayuki Honda, ... Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874, JapanSearch for more papers by this authorHideaki Nakashima, ... Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874, JapanSearch for more papers by this authorKenji Shibuta, ...
Tópico(s): Cytokine Signaling Pathways and Interactions
1995 - Wiley | International Journal of Cancer
CO 879, African (South), No. 874, Telegrams Relating to Affairs in South Africa
0000 - Gale Group | NCCO EuropeAfrica
L.Q. Zhang, Shengjie Sun, W.Y. Li, Zitong Feng, Xiaochao Xu, Q. Zhuang, Jun Fang,
... development and progression and aberrant expression of miR-874 have been found in some types of cancer.However, the expression and function of miR-874 in osteosarcoma remain unclear.The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development.The expression level of miR-874 was quantified by real-time reverse transcription-polymerase ... osteosarcoma cell lines and tissues.Using a miR-874 mimic, cell proliferation and migration assays were performed ... in order to determine the effects of miR-874 in osteosarcoma cell lines and tissues.MiR-874 ...
Tópico(s): Cancer-related molecular mechanisms research
2015 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research