Produção Nacional
Revisado por pares
Iris van ’t Erve, Nina J. Wesdorp, Jamie E. Medina, Leonardo Ferreira, Alessandro Leal, Joost Huiskens, Karen Bolhuis, Jan‐Hein T. M. van Waesberghe, Rutger‐Jan Swijnenburg, Daan van den Broek, Victor E. Velculescu, Geert Kazemier, Cornelis J.A. Punt, Gerrit A. Meijer, Remond J.A. Fijneman,
... mutation in KRAS G12, G13, Q61, K117, or A146. METHODS A total of 419 patients with colorectal ... 112), followed by mutations in G13 (N = 15), A146 (N = 12), Q61 (N = 9), and K117 (N = ... levels were observed for patients carrying a KRAS A146 mutation versus those with a KRAS G12 mutation, ... higher tumor load in patients harboring a KRAS A146 mutation (median TTV 672 cm 3 [A146] v 74 cm 3 [G12], P = .036). Moreover, KRAS A146 mutation carriers showed inferior overall survival compared with ... 003). CONCLUSION Patients with mCRC with a KRAS A146 mutation represent a distinct molecular subgroup of patients ...
Tópico(s): Cancer Genomics and Diagnostics
2021 - Lippincott Williams & Wilkins | JCO Precision Oncology
Brinda Subbarayal, Dirk Schiller, Christian Möbs, Wolfgang Pfützner, Beatrice Jahn‐Schmid, Barbara Gepp, Heimo Breiteneder, Stefan Vieths, Barbara Bohle,
... P35, S39, S40, S57, P59, D69, T142, L143, A146, Y150IAAPNSLRFSPL27. S39, I56, S57, F58, P59, L62, P63, ... F30, P31, P35, I56, I102, I116, M139, T142, A146, Y150APTIAYNTFMPM58. F22, I23, N28, F30, P31, P35, I56, F58, P59, M139, T142, A146, Y150APTIAYNTFMPM59. I56, F58, P59, P63, F64, Y66, P90, ... K134, A135, S13636LSSHKATSTRAD37. R17, D25, K32, L143, R145, A146, S149, L152, A153, H154, S155, D156, A157SLPFGPNTTIRP38. S39, ... I91, G92, S136LESHYTQASYTQ39. T9, T10, E141, T142, L143, A146, E148, S149, Y150, L152, A153, H154, A157, Y158Identical ...
Tópico(s): Asthma and respiratory diseases
2015 - Elsevier BV | Journal of Allergy and Clinical Immunology
Sarah Edkins, Sarah O’Meara, Adrian G. Parker, Claire Stevens, Marcelo Reis, Siân Jones, Chris Greenman, Helen Davies, Gillian L. Dalgliesh, Simon Forbes, Chris Hunter, Raffaella Smith, Philip Stephens, Peter Goldstraw, Andrew G. Nicholson, Tsun Leung Chan, Victor E. Velculescu, Siu Tsan Yuen, Suet Yi Leung, Michael R. Stratton, P. Andrew Futreal,
... Kong and the United States we detected KRAS A146 mutations in 7/126 and 2/94 cases, ... combined frequency of 4%. We also detected KRAS A146 mutations in 2/40 (5%) colorectal cell lines, ... 146 mutations. We did, however, identify a KRAS A146 mutation in the ML-2 acute myeloid leukemia cell line and an NRAS A146 mutation in the NALM-6 B-cell acute ...
Tópico(s): DNA Repair Mechanisms
2006 - Taylor & Francis | Cancer Biology & Therapy
Yasuyuki Ishii, Nobuaki Yamaguchi, Sachiko Idota,
... Wruk wona of the tiller weight type, Taiwan A146 of the tiller number type and Merkeron of ... the highest in Wruk wona, followed by Taiwan A146 and Merkeron in both cutting dates and the ... tiller. For the tiller number type of Taiwan A146, cutting was favorable in late July, due to ...
Tópico(s): Bioenergy crop production and management
2005 - Wiley | Grassland Science
Alice S. Booth, Charles J. Law, Milou Temmink, Margot Leemker, Enrique Macías,
The composition of a forming planet is set by the material it accretes from its parent protoplanetary disk. Therefore, it is crucial to map the chemical make-up of the gas in disks to understand the chemical environment of planet formation. This paper presents molecular line observations taken with the Atacama Large Millimeter/submillimeter Array of the planet-hosting disk around the young star HD 169142. We detect N 2 H + , CH 3 OH, [CI], DCN, CS, C 34 S, 13 CS, H 2 CS, H 2 CO, HC 3 N, and c–C 3 H 2 ...
Tópico(s): Atmospheric Ozone and Climate
2023 - EDP Sciences | Astronomy and Astrophysics
P. Serra, F. M. Maccagni, D. Kleiner, D. Cs. Molnár, M. Ramatsoku, A. Loni, F. Loi, W. J. G. de Blok, G. L. Bryan, R.‐J. Dettmar, B. S. Frank, J. H. van Gorkom, F. Govoni, E. Iodice, G. I. G. Józsa, P. Kamphuis, R. Kraan-Korteweg, S. I. Loubser, M. Murgia, Tom Oosterloo, R. F. Peletier, D. J. Pisano, M. W. L. Smith, S. C. Trager, Marc Verheijen,
The MeerKAT Fornax Survey maps the distribution and kinematics of atomic neutral hydrogen gas (HI) in the nearby Fornax galaxy cluster using the MeerKAT telescope. The 12 deg^2 survey footprint covers the central region of the cluster out to ~ Rvir and stretches out to ~ 2 Rvir towards south west to include the NGC 1316 galaxy group. The HI column density sensitivity (3 sigma over 25 km/s) ranges from 5e+19/cm^2 at a resolution of ~ 10" (~ 1 kpc at the 20 Mpc distance of Fornax) down to ~ 1e+18/cm^2 at ~ 1' (~ 6 ...
Tópico(s): Stellar, planetary, and galactic studies
2023 - EDP Sciences | Astronomy and Astrophysics
F. de Gasperin, L. Rudnick, A. Finoguenov, Denis Wittor, H. Akamatsu, M. Brüggen, James O. Chibueze, T. E. Clarke, W. D. Cotton, V. Cuciti, Paola Domínguez-Fernández, Kenda Knowles, S. P. O’Sullivan, Lerato Sebokolodi,
During their lifetime, galaxy clusters grow through the accretion of matter from the filaments of the large scale structure and from mergers with other clusters. These mergers release a large amount of energy into the intracluster medium (ICM) through merger shocks and turbulence. These phenomena are associated with the formation of radio sources known as radio relics and radio halos, respectively. Radio relics and halos are unique proxies to study the complex properties of these dynamically active ...
Tópico(s): Gamma-ray bursts and supernovae
2022 - EDP Sciences | Astronomy and Astrophysics
Tony Bonnaire, Nabila Aghanim, Joseph Kuruvilla, Aurélien Decelle,
We undertake the first comprehensive and quantitative real-space analysis of the cosmological information content in the environments of the cosmic web (voids, filaments, walls, and nodes) up to non-linear scales, $k = 0.5$ $h$/Mpc. Relying on the large set of $N$-body simulations from the Quijote suite, the environments are defined through the eigenvalues of the tidal tensor and the Fisher formalism is used to assess the constraining power of the power spectra derived in each of the four environments ...
Tópico(s): Astrophysics and Cosmic Phenomena
2022 - EDP Sciences | Astronomy and Astrophysics
W. A. van Cappellen, Tom Oosterloo, Marc Verheijen, Elizabeth A. K. Adams, B. Adebahr, Róbert Braun, Kelley M. Hess, H. A. Holties, J. M. van der Hulst, B. Hut, E. Kooistra, J. van Leeuwen, G. M. Loose, R. Morganti, V. A. Moss, E. Orrù, M. Ruiter, A. P. Schoenmakers, N. J. Vermaas, Stefan J. Wijnholds, A. S. van Amesfoort, M. Arts, Jisk Attema, L. Bakker, C. Bassa, J. E. Bast, P. Benthem, R. Beukema, R. Blaauw, W. J. G. de Blok, M.C. Bouwhuis, R. H. van den Brink, Liam Connor, A. H. W. M. Coolen, S. Damstra, G. N. J. van Diepen, R. de Goei, Helga Dénes, M. Drost, Nico Ebbendorf, B. S. Frank, D. W. Gardenier, Marchei Gerbers, Y. G. Grange, T. Grit, A. W. Gunst, N. Gupta, Marianna Ivashina, G. I. G. Józsa, G. H. Janssen, A. Koster, Gert Kruithof, S. Kuindersma, A. M. Kutkin, D. M. Lucero, Yogesh Maan, F. M. Maccagni, J. van der Marel, Á. Mika, J. Morawietz, H. Mulder, E. Mulder, M. J. Norden, A. R. Offringa, L. C. Oostrum, R. Overeem, Z. Paragi, H. J. Pepping, Emily Petroff, D. J. Pisano, A. G. Polatidis, Peeyush Prasad, J. P. R. de Reijer, John W. Romein, James C. Schaap, G. Schoonderbeek, R. Schulz, D. van der Schuur, Alessio Sclocco, J. Sluman, R. Smits, B. W. Stappers, Samayra Straal, K. J. C. Stuurwold, J. Verstappen, D. Vohl, K. J. Wierenga, E. E. M. Woestenburg, A. W. Zanting, J. Ziemke,
We describe the APERture Tile In Focus (Apertif) system, a phased array feed (PAF) upgrade of the Westerbork Synthesis Radio Telescope that transforms this telescope into a high-sensitivity, wide-field-of-view L -band imaging and transient survey instrument. Using novel PAF technology, up to 40 partially overlapping beams are formed on the sky simultaneously, significantly increasing the survey speed of the telescope. With this upgraded instrument, an imaging survey covering an area of 2300 deg 2 is ...
Tópico(s): Pulsars and Gravitational Waves Research
2021 - EDP Sciences | Astronomy and Astrophysics
Andrew J. Sweatt, Kazuya Miyagawa, Christopher J. Rhodes, Shalina Taylor, Patricia A. del Rosario, Andrew Hsi, François Haddad, Edda Spiekerkoetter, Michal Bental-Roof, Richard D. Bland, Emilia M. Swietlik, Stefan Gräf, Martin R. Wilkins, Nicholas W. Morrell, Mark R. Nicolls, Marlene Rabinovitch, Roham T. Zamanian,
... pathogenesis of pulmonary arterial hypertension.Thorax. 2013; 68 (A146-A146)Crossref PubMed Google Scholar Therapies that antagonize NE ...
Tópico(s): Cardiovascular Issues in Pregnancy
2021 - Elsevier BV | CHEST Journal
Amit Kumar, Marilyn Paul, Manoranjan Panda, Shruthi Jayaram, Narasimharaju Kalidindi, Harinath Sale, Muthalagu Vetrichelvan, Anuradha Gupta, Arvind Mathur, Brett R. Beno, Alicia Regueiro‐Ren, Dong Cheng, Manjunath Ramarao, Kaushik Ghosh,
... that a single amino acid change corresponding to A146 in human Gal-3 is sufficient for the ... between the fluorophenyl ring and the active site A146 (human Gal-3 and mouse V160A) that corroborate ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2021 - Oxford University Press | Glycobiology
T. Kohout, E. V. Petrova, G. A. Yakovlev, V. I. Grokhovsky, Antti Penttilä, Alessandro Maturilli, Juulia‐Gabrielle Moreau, С. В. Берзин, Joonas Wasiljeff, И. А. Даниленко, D. A. Zamyatin, Р. Ф. Муфтахетдинова, Mikko Heikkilä,
Shock-induced changes in ordinary chondrite meteorites related to impacts or planetary collisions are known to be capable of altering their optical properties. Thus, one can hypothesize that a significant portion of the ordinary chondrite material may be hidden within the observed dark C/X asteroid population. The exact pressure-temperature conditions of the shock-induced darkening are not well constrained. Thus, we experimentally investigate the gradual changes in the chondrite material optical ...
Tópico(s): Planetary Science and Exploration
2020 - EDP Sciences | Astronomy and Astrophysics
J. I. Gónzalez Hernández, R. Rébolo, L. Pasquini, G. Lo Curto, P. Molaro, E. Caffau, H.‐G. Ludwig, M. Steffen, M. Esposito, A. Suárez Mascareño, B. Toledo-Padrón, Rafael A. Probst, Theodor W. Hänsch, Ronald Holzwarth, A. Manescau, T. Steinmetz, Th. Udem, T. Wilken,
Context. The general theory of relativity predicts the redshift of spectral lines in the solar photosphere as a consequence of the gravitational potential of the Sun. This effect can be measured from a solar disk-integrated flux spectrum of the Sun’s reflected light on Solar System bodies. Aims. The laser frequency comb (LFC) calibration system attached to the HARPS spectrograph offers the possibility of performing an accurate measurement of the solar gravitational redshift (GRS) by observing the ...
Tópico(s): Adaptive optics and wavefront sensing
2020 - EDP Sciences | Astronomy and Astrophysics
William Pearson, L. Wang, Peter D. Hurley, K. Małek, V. Buat, D. Burgarella, D. Farrah, S. Oliver, D. J. B. Smith, F. van der Tak,
Context. Deep far-infrared (FIR) cosmological surveys are known to be affected by source confusion, causing issues when examining the main sequence (MS) of star forming galaxies. In the past this has typically been partially tackled by the use of stacking. However, stacking only provides the average properties of the objects in the stack. Aims. This work aims to trace the MS over 0.2 ≤ z < 6.0 using the latest de-blended Herschel photometry, which reaches ≈10 times deeper than the 5 σ confusion limit in ...
Tópico(s): Astrophysics and Star Formation Studies
2018 - EDP Sciences | Astronomy and Astrophysics
D. J. M. Petit dit de la Roche, H. J. Hoeijmakers, I. A. G. Snellen,
Context. In 2015, Barman et al. (ApJ, 804, 61) presented detections of absorption from water, carbon monoxide, and methane in the atmosphere of the directly imaged exoplanet HR8799b using integral field spectroscopy (IFS) with OSIRIS on the Keck II telescope. We recently devised a new method to analyse IFU data, called molecule mapping, searching for high-frequency signatures of particular molecules in an IFU data cube. Aims. The aim of this paper is to use the molecule mapping technique to search ...
Tópico(s): Stellar, planetary, and galactic studies
2018 - EDP Sciences | Astronomy and Astrophysics
Veronika Witzke, A. I. Shapiro, S. K. Solanki, N. A. Krivova, W. Schmütz,
Context. Comparison studies of Sun-like stars with the Sun suggest an anomalously low photometric variability of the Sun compared to Sun-like stars with similar magnetic activity. Comprehensive understanding of stellar variability is needed, to find a physical reasoning for this observation. Aims. We investigate the effect of metallicity and effective temperature on the photometric brightness change of Sun-like stars seen at different inclinations. The considered range of fundamental stellar parameters ...
Tópico(s): History and Developments in Astronomy
2018 - EDP Sciences | Astronomy and Astrophysics
Matilde Mingozzi, G. Cresci, Giacomo Venturi, A. Marconi, F. Mannucci, Michele Perna, Francesco Belfiore, Stefano Carniani, B. Balmaverde, M. Brusa, C. Cicone, C. Feruglio, Anna Gallazzi, V. Mainieri, R. Maiolino, Tohru Nagao, E. Nardini, E. Sani, P. Tozzi, S. Zibetti,
We investigated the interstellar medium properties of the disc and outflowing gas in the central regions of nine nearby Seyfert galaxies, all characterised by prominent outflows. These objects are part of the Measuring Active Galactic Nuclei Under MUSE Microscope survey, which aims to probe their physical conditions and ionisation mechanism by exploiting MUSE unprecedented sensitivity. We studied the different properties of the gas in the disc and outflow with spatially and kinematically resolved ...
Tópico(s): Astrophysical Phenomena and Observations
2018 - EDP Sciences | Astronomy and Astrophysics
Produção Nacional
Revisado por pares
B. Cseh, Maria Lugaro, V. D’Orazi, D. B. de Castro, C. B. Pereira, Amanda I. Karakas, L. Molnár, E. Plachy, R. Szabó, M. Pignatari, S. Cristallo,
Context. Barium (Ba) stars are dwarf and giant stars enriched in elements heavier than iron produced by the slow neutron-capture process (s process). They belong to binary systems where the primary star evolved through the asymptotic giant branch (AGB) phase,during which it produced the s-process elements and transferred them onto the secondary, now observed as a Ba star. Aims. We compare the largest homogeneous set of Ba giant star observations of the s-process elements Y, Zr, La, Ce, and Nd with ...
Tópico(s): High-pressure geophysics and materials
2018 - EDP Sciences | Astronomy and Astrophysics
Michiel Lambrechts, Elena Lega,
A large fraction of giant planets have gaseous envelopes that are limited to about 10 % of their total mass budget. Such planets are present in the Solar System (Uranus, Neptune) and are frequently observed in short periods around other stars (the so-called Super-Earths). In contrast to these observations, theoretical calculations based on the evolution of hydrostatic envelopes argue that such low mass envelopes cannot be maintained around cores exceeding five Earth masses. Instead, under nominal disc ...
Tópico(s): Stellar, planetary, and galactic studies
2017 - EDP Sciences | Astronomy and Astrophysics
E. Corbelli, J. Braine, R. Bandiera, N. Brouillet, F. Combes, C. Druard, P. Gratier, J. Mata, K. Schüster, E. M. Xilouris, F. Palla,
To shed light on the time evolution of local star formation episodes in M33, we study the association between 566 Giant Molecular Clouds (GMCs), identified through the CO (J=2-1) IRAM-all-disk survey, and 630 Young Stellar Cluster Candidates (YSCCs), selected via Spitzer-24~$\mu$m emission. The spatial correlation between YSCCs and GMCs is extremely strong, with a typical separation of 17~pc, less than half the CO(2--1) beamsize, illustrating the remarkable physical link between the two populations. ...
Tópico(s): Astronomy and Astrophysical Research
2017 - EDP Sciences | Astronomy and Astrophysics
S. Bagnulo, N. L. J. Cox, Aleksandar Cikota, R. Siebenmorgen, Н. В. Вощинников, F. Patat, Keith T. Smith, J. V. Smoker, S. Taubenberger, L. Kaper, J. Cami,
Polarimetric studies of light transmitted through interstellar clouds may give constraints on the properties of the interstellar dust grains. Traditionally, broadband linear polarisation (BBLP) measurements have been considered an important diagnostic tool for the study of the interstellar dust, while comparatively less attention has been paid to spectropolarimetric measurements. However, spectropolarimetry may offer stronger constraints than BBLP, for example by revealing narrowband features, and ...
Tópico(s): Atmospheric Ozone and Climate
2017 - EDP Sciences | Astronomy and Astrophysics
Produção Nacional
Revisado por pares
Aims. We investigate the process of Neptune trojan capture and permanence in resonance up to the present time based on a planetary instability migration model.
Tópico(s): Planetary Science and Exploration
2016 - EDP Sciences | Astronomy and Astrophysics
R. F. Díaz, J. Rey, O. D. S. Demangeon, G. Hébrard, I. Boisse, L. Arnold, N. Astudillo-Defru, Jean-Luc Beuzit, X. Bonfıls, S. Borgniet, F. Bouchy, V. Bourrier, B. Courcol, M. Deleuil, X. Delfosse, D. Ehrenreich, T. Forveille, A. M. Lagrange, M. Mayor, C. Moutou, F. Pepe, D. Queloz, A. Santerne, N. C. Santos, J. Sahlmann, D. Ségransan, S. Udry, P. A. Wilson,
We report the discovery of three new substellar companions to solar-type stars, HD 191806, HD 214823, and HD 221585, based on radial velocity measurements obtained at the Haute-Provence Observatory. Data from the SOPHIE spectrograph are combined with observations acquired with its predecessor, ELODIE, to detect and characterise the orbital parameters of three new gaseous giant and brown dwarf candidates. Additionally, we combine SOPHIE data with velocities obtained at the Lick Observatory to improve ...
Tópico(s): Astronomy and Astrophysical Research
2016 - EDP Sciences | Astronomy and Astrophysics
R. Schulz, A. Kreikenbohm, M. Kadler, R. Ojha, E. Ros, J. Stevens, P. G. Edwards, B. Carpenter, Dominik Elsässer, N. Gehrels, C. Großberger, H. Häse, S. Horiuchi, J. E. J. Lovell, K. Mannheim, A. Markowitz, Cornelia Müller, Chris Phillips, Christian Plötz, J. Quick, J. Trüstedt, A. K. Tzioumis, J. Wilms,
Gamma-ray detected radio-loud narrow-line Seyfert 1 (g-NLS1) galaxies constitute a small but interesting sample of the gamma-ray loud AGN. The radio-loudest g-NLS1 known, PKS 2004-447, is located in the southern hemisphere and is monitored in the radio regime by the multiwavelength monitoring program TANAMI. We aim for the first detailed study of the radio morphology and long-term radio spectral evolution of PKS 2004-447, which are essential to understand the diversity of the radio properties of ...
Tópico(s): Gamma-ray bursts and supernovae
2016 - EDP Sciences | Astronomy and Astrophysics
M. Vučković, R. H. Østensen, Péter Németh, S. Bloemen, P. I. Pápics,
Irradiation effects in close binaries are crucial for a reliable determination of system parameters and understanding the close binary evolution. We study irradiated light originating from the low mass component of an eclipsing system comprising a hot subdwarf primary and a low mass companion, to precisely interpret their high precision photometric and spectroscopic data, and accurately determine their system and surface parameters. We re-analyse the archival VLT/UVES spectra of AA Dor system where ...
Tópico(s): Astronomy and Astrophysical Research
2015 - EDP Sciences | Astronomy and Astrophysics
A. S. Baran, S. Zoła, A. Blokesz, R. H. Østensen, R. Silvotti,
We analyze 37 months of Kepler photometry of 2M 1938+4603, a binary system with a pulsating hot subdwarf primary and an M-dwarf companion that shows strong reflection effect. We measured the eclipse timings from more than 16 000 primary and secondary eclipses and discovered a periodic variation in the timing signal that we ascribe to a third body in the system. We also discovered a significant long-term trend that may be an evolutionary effect or a hint of more bodies. Upon the assumption that the ...
Tópico(s): Astrophysics and Star Formation Studies
2015 - EDP Sciences | Astronomy and Astrophysics
Marco Minissale, E. Congiu, F. Dulieu,
Physisorbed atoms on the surface of interstellar dust grains play a central role in solid state astrochemistry. Their surface reactivity is one source of the observed molecular complexity in space. In experimental astrophysics, the high reactivity of atoms also constitutes an obstacle to measuring two of the fundamental properties in surface physics, namely desorption and diffusion energies, and so far direct measurements are non-existent for O and N atoms. We investigated the diffusion and desorption ...
Tópico(s): Atmospheric Ozone and Climate
2015 - EDP Sciences | Astronomy and Astrophysics
Yusi Liu, Hong Wang, Shuai Zhang, Lingbin Zeng, Xiuyu Xu, Kaifeng Wu, Wei Wang, Nanlin Yin, Zhixin Song, Xuemei Zhang, Yibing Yin,
... form of Ply that has a deletion of A146 (ΔA146Ply-DnaJ [the C terminus of ΔA146Ply connected ... plus ΔA146Ply (Ply with a single deletion of A146) could significantly reduce S. pneumoniae colonization in the ...
Tópico(s): Respiratory viral infections research
2014 - American Society for Microbiology | Infection and Immunity
Miho N. Ishigaki, Wako Aoki, N. Arimoto, Sakurako Okamoto,
Context. Ultra-faint dwarf galaxies recently discovered around the Milky Way (MW) contain extremely metal-poor stars, and might represent the building blocks of low-metallicity components of the MW. Among them, the Boötes I dwarf spheroidal galaxy is of particular interest because of its exclusively old stellar population. Detailed chemical compositions of individual stars in this galaxy are a key to understanding formation and chemical evolution in the oldest galaxies in the Universe and their roles ...
Tópico(s): Astronomy and Astrophysical Research
2014 - EDP Sciences | Astronomy and Astrophysics
Alexandra Kozyreva, Sung-Chul Yoon, N. Langer,
Context. Both recent observations and stellar evolution models suggest that pair-instability supernovae (PISNe) could occur in the local Universe, at metallicities below ≲Z⊙/3. Previous PISN models were mostly produced at very low metallicities in the context of the early Universe.
Tópico(s): Nuclear physics research studies
2014 - EDP Sciences | Astronomy and Astrophysics