... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which did not use a thiazide at all? ... by the National Heart, Lung and Blood Institute ALLHAT/JNC 7 "dissemination project,"2 which reached more ... and lisinopril in preventing cardiovascular (CV) events in ALLHAT, was not HCTZ but chlorthalidone,4 which is ... be as good as amlodipine and lisinopril in ALLHAT. As stated, chlorthalidone is not a thiazide diuretic, so the reference to ALLHAT in all of the enthusiastic endorsements of thiazide ... Second Australian National Blood Pressure Study (ANBP2).19 ALLHAT reported fewer events for combined CV disease, stroke, ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2011 - Wiley | Journal of Clinical Hypertension
... and Lipid-Lowering Treatment to Prevent Heart Trial (ALLHAT) was a randomized, double-blind, practice-based hypertension ... 15 094 were black and 8100 Hispanic).8 ALLHAT participants were followed from 1994 to 2002 for ... coronary heart disease, renal failure, and premature death. ALLHAT was designed to compare the effects on cardiovascular ... of several apparently well-tolerated generic medications.16 ALLHAT results addressed 2 important barriers to effective treatment ... control rate was similar to that achieved in ALLHAT (61%) using organizational-level approaches.9 Although representing ...
Tópico(s): Health disparities and outcomes
2009 - Lippincott Williams & Wilkins | Circulation Cardiovascular Quality and Outcomes
Jeffrey A. Cutler, Barry R. Davis,
... Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Download figureDownload PowerPointFigure 1. Percentage of drug mentions ... Table 2. Outcomes in the BP Component of ALLHAT by Treatment Group as of February 15, 200026OutcomesTotal ... With regard to applicability of these conclusions, although ALLHAT was conducted in high-risk patients to ensure ... Differences in ALLHATOne of the main criticisms of ALLHAT was that its outcome findings (especially the subgroup ... a partial explanation, except for heart failure. In ALLHAT, the small differences in achieved mean systolic BP ...
Tópico(s): Sodium Intake and Health
2008 - Lippincott Williams & Wilkins | Circulation
... ScholarIn 2002, the lipid-lowering trial component of ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), or ALLHAT-LLT, reported that randomization to receive pravastatin 40 ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT).JAMA. 2002; 288: 2998-3007Crossref PubMed Scopus ( ... unique aspects of the design and conduct of ALLHAT-LLT (rather than lack of efficacy for statins ... hoc analysis of data from a subgroup of ALLHAT-LLT participants, and compare the risk of kidney ...
Tópico(s): Pharmaceutical Economics and Policy
2008 - Elsevier BV | American Journal of Kidney Diseases
... metabolic dysfunctions' of thiazide diuretic2.Houston M.C. ALLHAT debate: diuretics are not preferred, first-line initial ... B.H. Hebert C.J. The design of ALLHAT may have biased the study's outcome in ... B.H. Hebert C.J. The design of ALLHAT may have biased the study's outcome in ... B.H. Hebert C.J. The design of ALLHAT may have biased the study's outcome in ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), the Joint National Committee on Prevention, Detection, Evaluation, ... 2572Crossref PubMed Scopus (15057) Google Scholar Although the ALLHAT investigators have acknowledged diuretic's metabolic perturbations, they ...
Tópico(s): Renin-Angiotensin System Studies
2007 - Elsevier BV | Kidney International
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study is among the largest and most ambitious. ... of other related data from similar studies.In ALLHAT, both the primary outcomes (fatal CHD and nonfatal ... particularly persuasive.What therefore are the implications of ALLHAT and other trials? With regard to heart failure, ... less with ACE inhibitors in some trials (eg, ALLHAT). After adjustment for the degree of BP lowering, ... Med. 2005; 165: 1410–1419.CrossrefMedlineGoogle Scholar8 The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2006 - Lippincott Williams & Wilkins | Circulation
Peter T. Sawicki, Natalie McGauran,
HomeHypertensionVol. 48, No. 1Have ALLHAT, ANBP2, ASCOT-BPLA, and So Forth Improved Our Knowledge About Better Hypertension Care? Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd ... ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReview ArticlePDF/EPUBHave ALLHAT, ANBP2, ASCOT-BPLA, and So Forth Improved Our ... Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT). The results and implications of ALLHAT and 2 other controversially discussed studies, namely, the ...
Tópico(s): Hormonal Regulation and Hypertension
2006 - Lippincott Williams & Wilkins | Hypertension
Franz H. Messerli, Jan A. Staessen,
... Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) compared in >30 000 high-risk hypertensive patients ... by the National Heart, Lung, and Blood Institute, ALLHAT stands out because no differences occurred in the ... infarction.1 Not surprisingly, the attention of the ALLHAT consortium shifted to secondary end points, such as ... failure. At the end of the line, the ALLHAT investigators based their main conclusions on events that, ... mm Hg diastolic.1 These salient features of ALLHAT should be kept in mind whenever one attempts ...
Tópico(s): Pharmacology and Obesity Treatment
2006 - Lippincott Williams & Wilkins | Hypertension
... Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) in 2002, diuretic prescriptions increased by early 2003 ... 2004, although the use of diuretics exceeded pre-ALLHAT levels, their use had declined from their peak ... they are the most cost-effective antihypertensive agent.ALLHAT was a randomized, double-blind clinical trial, involving > ... for different classes of antihypertensive agents.7 The ALLHAT investigators concluded that, "Thiazide type diuretics are superior ... States also point out that JNC recommendations and ALLHAT have had relatively little long-term impact on ...
Tópico(s): Pharmaceutical industry and healthcare
2006 - Lippincott Williams & Wilkins | Hypertension
Craig S. Stump, Marc T. Hamilton, James R. Sowers,
... a calcium channel blocker: a report from the ALLHAT trial.Am J Hypertens. 2004; 17: 1ACrossref PubMed ... a calcium channel blocker: a report from the ALLHAT trial.Am J Hypertens. 2004; 17: 1ACrossref PubMed ... a calcium channel blocker: a report from the ALLHAT trial.Am J Hypertens. 2004; 17: 1ACrossref PubMed ... a calcium channel blocker: a report from the ALLHAT trial.Am J Hypertens. 2004; 17: 1ACrossref PubMed ... Lipid-Lowering Treatment to Prevent Heart Attacks Trial (ALLHAT),24Barzilay JI Pressel S Davis BR et al. ...
Tópico(s): Sodium Intake and Health
2006 - Elsevier BV | Mayo Clinic Proceedings
Anne L. Taylor, Jackson T. Wright,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Anne L. Taylor, MD and Jackson T. WrightJr, ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)7–9 is an example of a clinical ... high-risk hypertensives aged 55 years and older. ALLHAT had a goal of recruiting a sufficiently large ... prevalence, outcomes, and treatment responses to hypertension, before ALLHAT, there were no studies that evaluated cardiovascular outcomes in black patients either in progress or planned.ALLHAT recruited more than 15 100 black subjects of ...
Tópico(s): Race, Genetics, and Society
2005 - Lippincott Williams & Wilkins | Circulation
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) publication. A comparison of 8097 patients randomized to ... the historical context when the results of the ALLHAT trial became available, a randomized double-blind multicentre ... of participants in the three arms of the ALLHAT study (n = 33 357) is only slightly less ... not significantly different between amlodipine and chlorthalidone in ALLHAT (relative risk 0.98; P = 0.65). Therefore, ALLHAT does not confirm the 12% higher incidence with ... lower incidence with amlodipine than with chlorthalidone in ALLHAT (P = 0.28). A true advantage of CCBs ...
Tópico(s): Hormonal Regulation and Hypertension
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
... events [12]. A bigger trial was needed and ALLHAT offered the welcome prospect of a definitive comparison ... therapy and treatment based on newer drugs [13]. ALLHAT (Antihypertensive and Lipid Lowering to prevent Heart Attack ... before changes in clinical practice are adopted. The ALLHAT results were achieved only at enormous cost. Was ... or similar. This was not the case in ALLHAT. Five-year systolic blood pressure were significantly higher ... risk populations [15, 16] such as studied in ALLHAT. The difference in systolic blood pressure control between ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) constitutes a triumph for diuretics, hard end-points ... pressure lowering drugs versus diuretics and beta-blockers, ALLHAT delivers the goods, and provides a clear result ... some questions unanswered and poses some new questions. ALLHAT was a randomized, double-blind, prospective comparative study, ... therapy in hypertensive subjects was established well before ALLHAT, in many studies confirming their benefit in reducing ... diuretics The outstanding feature of the results of ALLHAT was that across a large number of comparisons ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is the largest and, in most ways, among ... of a low-dose diuretic for initial therapy, ALLHAT confirms the conclusions from multiple placebo-controlled trials ... heart failure. Chlorthalidone was the diuretic used in ALLHAT whereas hydrochlorothiazide is by far the most widely ... the USA. Evidence-based purists may insist that ALLHAT only proves the efficacy of chlorthalidone, but it ... averaging 156/89 mmHg, in the previously untreated ALLHAT participants likely explains the lesser need for additional ...
Tópico(s): Renin-Angiotensin System Studies
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
Franz H. Messerli, Michael A. Weber,
... Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) 1 The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research GroupMajor outcomes in high-risk hypertensive ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002; 288: 2981-2997 Crossref PubMed Scopus ( ... Implications of discontinuation of doxazosin in arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart ... PubMed Scopus (62) Google Scholar The results of ALLHAT have been reported, 1 The ALLHAT Officers and ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2003 - Elsevier BV | The American Journal of Cardiology
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Practical Implications Suzanne Oparil Suzanne OparilSuzanne Oparil From ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), sponsored by the National Heart, Lung, and Blood ... in the past decade.1 The rationale for ALLHAT, which was designed in the early 1990s, was ... Design and Baseline DataIn response to these needs, ALLHAT was designed to test the primary hypothesis that ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2003 - Lippincott Williams & Wilkins | Hypertension
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)1 was literally front page news. After all, ... preventing major cardiovascular events. More than that, the ALLHAT authors pointed out that because thiazide-like diuretics ... become possible to digest the lengthy and detailed ALLHAT report, serious questions have arisen not only as ... important to take a closer look at the ALLHAT data and evaluate the validity of the claims ... much so, that the "HAT" in the title, "ALLHAT," stands for Heart Attack Trial. The results of ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2003 - Wiley | Journal of Clinical Hypertension
The recent results of the ALLHAT study [1] are an important contribution to the therapeutics of hypertension. However, the early conclusions in the press, and comments by some opinion leaders that ALLHAT proved that diuretics ought to be the firstline ... with hypertension, are surprising. There is nothing in ALLHAT to support such a wide generalization. Let us start with the obvious: ALLHAT did not investigate initiation of treatment. In 90% of patients, ALLHAT evaluated the effect of 'roll over' from previous ...
Tópico(s): Hormonal Regulation and Hypertension
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
Mustafa I. Ahmed, David A. Calhoun,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is probably the most relevant in that it ... year treatment period, uncontrolled hypertension was common in ALLHAT, with 34% of subjects never having achieved BP ... hypertensive cohorts.1The problem, of course, is that ALLHAT and other clinical trials were not designed to ... the very obese, and, in the case of ALLHAT, patients with a known history of RHTN (ie, ... Hypertension. 2008; 51: 1403– 1419. LinkGoogle Scholar2. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research ...
Tópico(s): Hormonal Regulation and Hypertension
2011 - Lippincott Williams & Wilkins | Hypertension
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) on the effect of the initial drug used ... their hypertension.Davis et al4 identified in the ALLHAT patients 1367 hospitalizations classified as being for HF ... potential error in measuring EF. Furthermore, in the ALLHAT analysis, 201 patients only had a subjective evaluation ... as normal, borderline, or impaired.The patients in ALLHAT did not neatly fall into 2 groups divided ... further supported by this important analysis of the ALLHAT data by Davis et al.4The opinions expressed ...
Tópico(s): Heart Failure Treatment and Management
2008 - Lippincott Williams & Wilkins | Circulation
... Lipid Lowering treatment to prevent Heart Attack Trial (ALLHAT).2,3 In the latter, treatment beginning with ... comparisons, other cardiovascular disease (CVD) events.However, in ALLHAT mean fasting blood glucose (FBG) and incident diabetes ... glucose, or diabetes).4 One point about the ALLHAT results that has not received enough emphasis is ... analyses that the authors suggest for performing in ALLHAT and SHEP, because the biochemical measures in those ... JAMA. 1997; 277: 739–745.CrossrefMedlineGoogle Scholar3 The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research ...
Tópico(s): Sodium Intake and Health
2006 - Lippincott Williams & Wilkins | Hypertension
Diana B. Petitti, Fagen Xie, Joshua I. Barzilay,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) published its main findings in December, 2002. It ... Health Maintenance Organization--two regions that had an ALLHAT clinical center and two that did not. We ... the period 2 or 3 years before the ALLHAT main publication through December 31, 2004 was calculated ... In the 2 years after publication of the ALLHAT trial findings, the percentage of all prescriptions for ... 12.4% in the two regions with an ALLHAT clinical site and from 8.9% to 10.1% in the two regions without an ALLHAT clinical site (p > 0.05). The percentage of ...
Tópico(s): Pharmaceutical industry and healthcare
2006 - Elsevier BV | Contemporary Clinical Trials
Norman K. Hollenberg, Murray Epstein,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), the largest antihypertensive study performed to date (7). ... contributed to the development of ESRD (9). The ALLHAT was not designed specifically to address the issue ... extremely unlikely that the investigators missed ESRD. What ALLHAT found was that patients who were treated with ... the earlier studies were “wrong” and that the ALLHAT—presumably by virtue of the fact that it ... 300 mg/d irbesartan (4). What of the ALLHAT? They initiated lisinopril treatment with a daily dose ...
Tópico(s): Chronic Kidney Disease and Diabetes
2006 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)6 was helpful in putting this issue in ... and was superior to a thiazide in the ALLHAT study,6 the result in VALUE may have ... of the American Society of Hypertension by the ALLHAT authors.14 In a follow-up to their ... study drugs on incident diabetes. In particular, the ALLHAT study divided its hypertensive patients into two groups: ... we should briefly acknowledge the claim by the ALLHAT authors—both in their original paper,6 and ... had relatively high baseline glucose values (as in ALLHAT) and also those who got treatment with a ...
Tópico(s): Diet and metabolism studies
2004 - Wiley | Journal of Clinical Hypertension
Andrew S. Levey, Katrin Uhlig,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). The outcomes of kidney disease in the same ... 4). These reports are important because 17% of ALLHAT participants had chronic kidney disease, making it the ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. 2005;165:936-46. [PMID: ... 2001;135:73-87. [PMID: 11453706] LinkGoogle Scholar7. ALLHAT Collaborative Research Group. Major outcomes in high-risk ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288:2981-97. [PMID: 12479763] CrossrefMedlineGoogle ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2006 - American College of Physicians | Annals of Internal Medicine
Vincenza Snow, Kevin B. Weiss, Christel Mottur-Pilson,
... Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) is the largest trial of blood pressurelowering therapy ... or less.In addition to STOP-2 and ALLHAT, two trials have compared -blockers, diuretics, or both ... agent used.In addition to STOP-2 and ALLHAT, two other studies have compared calcium-channel blockers ... pressure control in most patients with diabetes.In ALLHAT, no difference was shown in cardiovascular events or ... therapy for African-American patients. Further analyses from ALLHAT of high-risk renal subgroups, such as self- ...
Tópico(s): Pharmacology and Obesity Treatment
2003 - American College of Physicians | Annals of Internal Medicine
John H. Laragh, Jean E. Sealey,
... Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were published on December 18, 2002, in the Journal of the American Medical Association.1 ALLHAT is the largest trial of its kind, involving ... hundreds of other physicians and professionals participated in ALLHAT on an almost daily basis. The ALLHAT patients had a mean age of 67 years, ... their seated blood pressures (BPs) controlled to the ALLHAT goal of !140/90 mm Hg. The ALLHAT study design has some unique features: first 90% ... stroke or heart failure. In this setting, the ALLHAT study groups, including their investigators, officers, and coordinators ...
Tópico(s): Heart Failure Treatment and Management
2003 - Oxford University Press | American Journal of Hypertension
Alberto Zanchetti, Giuseppe Mancia,
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) trial results has prompted the Editors of the ... trial, even of an excellent trial such as ALLHAT, are taken as a verdict, rather than a ... hypertension research, some of which disproved by the ALLHAT results themselves. The readers of the Journal of ... be equally interested in knowing which questions the ALLHAT trial has not answered and are still left ... peculiar and unusual combination therapy required by the ALLHAT design have some influence on the results, and ...
Tópico(s): Blood Pressure and Hypertension Studies
2003 - Lippincott Williams & Wilkins | Journal of Hypertension
... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Free AccessOtherDownload EPUBAboutView EPUBSections ToolsAdd to favoritesDownload citationsTrack ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Ruth SoRelle Ruth SoRelleRuth SoRelle Originally published28 Mar ... Institute (NHLBI) halted one part of the large ALLHAT high blood pressure study because one of the ... nih.gov/new/press/mar08-00.htm).The ALLHAT study was designed to have 2 parts. One ... congestive heart failure."The other part of the ALLHAT study dealing with high cholesterol will continue until ...
Tópico(s): Blood Pressure and Hypertension Studies
2000 - Lippincott Williams & Wilkins | Circulation