Andrew Robson, Amanda Andrews, Robert Dawson Scott, Richard Whitehead, Matthew Syed, A. P. Herbert, Sue Watson, Sarah Potter, Edward Witten, Peter Lansley, David Barrie Director, The Art Fund, Mark Souster, Rose James, Ivo Tennant, Michael Evans Defence Editor, Simon Cambers, Jill Sherman and Lewis Smith, Maia Szalavitz, Christine Seib, Daniel Balint-Kurti and Jonathan Clayton, David Chater, Jeremy Kingston, Joanna Bale, Nick Daws, David Lynch, Elizabeth Judge, Carol Sarler, Richard Irving, Gabrielle Starkey, Heather Neill, Pat Gibson, Eric R. Kandel, Jane MacArtney, Nick Elsley, John Wardle, Tom Bawden, Alexander Levitzki, Debra Craine, Shirley English, Gary Jacob, Jill Dupleix, Tim Reid, Mark Benables, Dalya Alberge Arts Correspondent, Caroline Flint, Alan Hamilton, Laszlo Lovasz, Anatole Kaletsky, Phil Gordon, Keith Pike, Charles Bremner, Ian MacKinnon, Ron Lewis, Adam Sherwin Media Correspondent, Liz Chong, Edward Gorman, Angela Jameson, Anthony Hollis, Oliver Kay, Ian Osborne, David Lister, Lisa Armstrong, John Westerby, Neil Harman, David Lawrenson, Sam Coates, Pete Paphides, Geoffrey Dean, Pierre-Gilles de Gennes, Alice Olins, Gabriel Rozenberg, Neil Harman Tennis Correspondent, Raymond Keene, Christine Buckley, Lewis Smith, Matthew Pryor, Matt Dickinson, Richard Rawsthorn, Marcus Binney Architecture Correspondent, Caroline Merrell, Imre Kertesz, Chris Campling, Fran Yeoman, Cathy Harris, Damian Whitworth, Roger Boyes, Gabriel Rozenberg Economics Reporter, Dalya Alberge, Owen Slot Chief Sports Reporter, David Hands Rugby Correspondent, Tom Dart, Julian Muscat, William Rees-Mogg, Tim Hames, Craig Lord, Anjana Ahuja, George Caulkin, Caitlin Moran, Neil Fisher, Jill Sherman Will Pavia and Fran Yeoman, Walter Gammie, George A. Olah, Keith Malcouronne, Sir Aaron Klug, Tim Flannery, Peter Jenson, Jacqui Goddard, David H. Hubel, Janet Museveni, Mark Henderson, Miranda Pender, Danny Baker, Ashling O'Connor, Brian Ward, Dr Thomas Stuttaford, Stephen Dalton, Stephen Gardiner, Leo Lewis, Richard Morrison, Sir Michael Atiyah, David Powell, Bill Edgar, Alyson Rudd, Richard Edwards, Abigail Rayner, Valerie Elliott Dominic Kennedy and Charles Bremner, Richard Owen and Sam Coates, Nick Meo, Mark Bristow, Christopher Irvine, Emma Chesterman, Elie Wiesel,
The Times Corruption trial Murray triumph The Game Hamas cut off Council tax rise pushes family bills over £2,000 Will you retire at 85? Top Increases ...
2006 - Gale Group | TDA
... Regulatory Proteins and Their Interaction with DNA AARON KLUG, AARON KLUG MRC Laboratory of Molecular Biology Cambridge, CB2 ... EnglandSearch for more papers by this author AARON KLUG, AARON KLUG MRC Laboratory of Molecular Biology Cambridge, CB2 2QH, ...
Tópico(s): RNA and protein synthesis mechanisms
1995 - Wiley | Annals of the New York Academy of Sciences
Andrew Robson, Christopher Granville, Gabriel Rozenberg and Gary Duncan, David Adams, Dr Adrian Gregory, Professor Sir Paul Nurse, Professor Sir Aaron Klug, Keith Ross, Djm, Joanna Taylor, Frances Gibb Legal Editor, Gary Duncan, Ben Hoyle and Marcus Oscarsson, Mark Souster, Richard Hobson, Nick Hawton, Ivo Tennant, Tim Love Joy, Matt Wolf, Philip Howard, Hilary Finch, Carol Midgley, Christine Seib, David Irvine, Fidel Castro, David Chater, Joanna Bale, Richard Kemp, Alexandra Frean Social Affairs Correspondent, Elizabeth Judge, Jenny Abramsky, Director, Sean O'Neill and Richard Ford, Patrick Kidd, Sam Marlowe, Jeremy Whittle, Kevin Eason, Geoff Brown, Professor James D. Watson, Sean O'Neill and Stewart Tendler, Sir Jeremy Beecham Vice-chairman, Professor Sir John Sulston, Pat Gibson, Jane MacArtney, Stewart Tendler Crime Correspondent, Professor Robert H. Horvitz, Daniel McGrory and Ali Hamdani, Joanna Weinberg, Dan Sabbagh Media Editor, James Doran Wall Street Correspondent, Michael Horsnell and Lewis Smith, Jill Dupleix, Rosemary Bennett, Dan Sabbagh, Stephen Farrell, Professor Sir John Walker, Olly kendall, Sid Smith, David Hands, Ron Lewis, Stefanie Marsh, David Howell, Edward Gorman, Danny Kelly, Sarah Butler James Doran and Martin Waller, Russell Kempson, Micheal Evans, Daniel McGrory, Oliver Kay, Neil Harman, Rick Broadbent, Julian Evans, Tom Baldwin, Dr Frederick Sanger, Alice Olins, R. H. G. Young President, Gabriel Rozenberg, Neil Harman Tennis Correspondent, David Powell Athletics Correspondent, Raymond Keene, Adam Sage, Matthew Pryor, Margaret Eaton, Professor Sir Peter Mansfield, Ned Parker and Rosemary Bennett Deputy Political Editor, Dr Tanya Byron, Rosemary Bennett Deputy Political Editor, Kaveh Solhekol, Chris Campling, Cathy Harris, Mrs Danny Murphy, Kate Rew, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Damian Whitworth, Roger Boyes, Magnus Grimond and Patrick Hosking, Peter Dixon, Lucy Powell, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Julian Muscat, Paul Simons, William Rees-Mogg, Robert Crampton, Tony Halpin Educational Editor, Tim Hames, Valerie Elliott Consumer Editor and Joanna Bale, Ashling O'connor, Anjana Ahuja, Caitlin Moran, Neil Fisher, Peter Haigh, Catherine O'Brien, Professor Sydney Brenner, Peter Busby, Sir Sandy Bruce-Lockhart, chairman, Kirsty Lang, Simon Evers, Lewis Stuart, Lisa Verrico, James Jackson, Danny Baker, Nigel Hawkes Health Editor, Sarah Butler, Terry Wynn, Chairman, Dr Thomas Stuttaford, Stephen Dalton, Ben Hoyle, Dr Tim Hunt, Leo Lewis, Frances Gibb, James Christopher, Liz Whittle, Mark Venables, Alexandra Blair Education Correspondent, Olav Bjortomt, Edward Gorman Sailing Correspondent, Peter Klinger, Sam Lister Health Correspondent, Christopher Irvine,
The Times $45m ransom paid for Iraq hostages Hope from disaster Painkiller warning Win Champagne Su Doku Takeover pressure Watford go up Index timesonline ...
2006 - Gale Group | TDA
... 4 ArticleFree Access The Human Genome Project Aaron Klug, Aaron KlugSearch for more papers by this author Aaron Klug, Aaron KlugSearch for more papers by this author First ...
Tópico(s): Nutrition, Genetics, and Disease
2001 - Wiley | IUBMB Life
David Bellamy (Botanist and broadcaster), Martin Berthoud, Tunku Varadarajan, Riddell, Jon Ashworth, David Adams, Helen Johnstone, Alexandra Frean, Patricia Davies, Adrian Lee, Jeremy Laurance, Andrew Longmore, Ronald Davie (Chairman, Policy Sub-Committee), Ivo Tennant, Philip Howard, Carol Midgley, Jeremy Kingston, Alexandra Frean Media Correspondent, John Habgood (Archbishop of York), George Sivell, Lynne Truss, Carl Mortished, Morag Preston, Simon Wilde, Roger Maynard, Tim Congdon (Member, Treasury Panel of Independent Forecasters), Tony Patrick, Clare Stewart, Martin Holdgate (President, Zoological Society of London), John Dunford, Robert Miller, Robert Sheehan, Bridge Correspondent, Martin Fletcher, Pat Gibson, John Clarke, John Melvin, John Hopkins, Golf Correspondent, Kate Alderson and Richard Ford, Alice Thomson and Andrew Pierce, Ann Scanlon, Peter Ball, Ruth Gledhill, John Houghton, Chairman, Debra Craine, Raymond Keene Chess Correspondent, Peter Waymark, Robin Young, Jill Sherman Chief Political Correspondent, Pat Collarbone and Barbara MacGilchrist, Michael Clark, Jeremy Laurance, Health Correspondent, James Landale Political Reporter, Dick Davison, Quentin Letts, Charles Bremner, Sarah Bagnall, Aaron Klug (President, Royal Society), Susan Band, T. L. Johnston (President, Royal Society of Edinburgh), Philip Bassett, Michael Theodoulou, M. McEwen Charlish, I. Nottingham, David Miller, Ghillean Prance (Director, Royal Botanic Gardens, Kew), Alan Toogood, Horticulture Correspondent, David Powell Athletics Correspondent, Raymond Keene, David Charter, Education Correspondent, Jeremy Laurance and Dominic Kennedy, Christine Buckley, Peter Davalle, Alan Lee, Cricket Correspondent, Emma Wilkins, Robin Crawford, M. Brown (Director of Sport and Recreation), R. J. Berry (Chairman), Alix Ramsay, P. H. S, Astor of Hever (Vice-President, Hearing Research Trust), Lawrence Freedman, Richard Evans, Nigel Hawkes, Alice Thomson, Jill Sherman, Richard Owen, Roger Boyes, Nigel Hawkes, Science Editor, James Woodall, Oliver August, Ansel Harris, Kate Alderson, David Price, Philip Webster Political Editor, Christopher Walker, Kathryn Knight, Gerald Larner, Matthew Parris, Richard Evans Racing Correspondent, Brian Young, Russell Jenkins, Stephen Bruton, Caitlin Moran, Ben MacIntyre, Michael Gove, Richard Beeston, Philip Jeune, Guy de la Bedoyere, David Sinclair, Michael Horsnell, Kevin McCarra and Oliver Holt, Frank Le Duc, Benedict Nightingale, Dominic Kennedy, Social Affairs Correspondent, Tom Rhodes, Dr Thomas Stuttaford, Jack Bailey, Alyson Rudd, Steve Voce, Valerie Grove, Michael Henderson, I. Mills, David Maddock, Alasdair Murray, Robert Whymant, Jan Raath, Richard Ford, Clement Freud,
Today Jeans Means Money Thatcher rebuked by angry Major Scientists find direct evidence for BSE link Rhino kills Briton on reserve Index Caitlin Moran ...
1996 - Gale Group | TDA
... biological assemblies: Nobel lecture, 8 December 1982 Aaron Klug Aaron Klug 1MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, ... LinkedIn MailTo Cite Icon Cite Get Permissions Citation Aaron Klug; From macromolecules to biological assemblies: Nobel lecture, 8 ...
Tópico(s): Advanced Electron Microscopy Techniques and Applications
1983 - Portland Press | Bioscience Reports
Giles Smith, Andrew Robson, Janice Turner, Christina Hardyment, David Brown, Patrick Foster Media Correspondent, Leo Lewis Asia Business Correspondent, Zahid Hussain, Amanda Ursell, Simon Barnes, Jane MacQuitty, Laura Whateley, Kathleen Wyatt Travel Editor, Peter Lansley, Ashling O'Connor Olympics Correspondent, Demi Moore, Simon Hills, Robert Lindsay, Christopher Wood, Claire McDonald, Mark Souster, Paul Hoggart, Mark Frary, Catherine Boyle, David Rose, Sue Bryant, John Mulvey, Ivo Tennant, Tony Turnbull, Michael Evans Defence Editor, Emma Cook, Philip Howard, Carol Midgley, Pat Wayzgoose, David Smith, Ian King, David Chater, Ben Hoyle Arts Reporter, Kate Wighton, Rachel Campbell-Johnston, Melissa Katsoulis, Fern Britton, Murad Ahmed, Clive Davis, David Jager, Patrick Kidd, Gráinne Gilmore Economics Correspondent, Graham Stewart, Lauren Thompson, David Charter Europe Correspondent, Councillor Daniel Moylan Chairman, Sean Creighton, Louie Spence, Bob Stanley, Jane Taylor-Hayhurst, John Bungey, Geoff Brown, Tony Baylis, Rob Wright Champion Tipster, Joe Joseph, Giles Coren, David Sharrock, Vivienne Parry, Caroline Hendrie, Martin Fletcher, Dr Copperfield, Sean O'Neill Crime Editor, Caroline Sylger Jones, John Arlidge, Nancy Durrant, Jane MacArtney, Hilary Rose, Rachel Sylvester, Francis Elliott, Sian Powell, Deborah Haynes, Dominic Walsh, Dan Sabbagh Media Editor, Debra Craine, Jim Johnston, Ruth Corbett, Rory Watson, Gary Jacob, Joe Swift, Michael Forrest, Jeremy Clarkson, Tom Charity, Allan Simmons, Peter Stiff, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Dan Sabbagh, Gerald Gouriet, Tom Gatti, Jo Morris, Martin Waters, Derek Crapper, Henry Hitchings, Jenny MacArthur, Elaine Feinstein, Rhys Blakely, Valerie Elliott Consumer Editor, Andrew Ellson Personal Finance Editor, Richard Lloyd Parry, David Hands, Charles Bremner, Graham Keeley, Caroline White, Ron Lewis, Martin Symington, Ben MacHell, Mark Ogden, Lucy Sweeney, David Charter, Susan Thompson, Lilly Peel, Hugo Rifkind, John Whiteley, Derwent May, Angela Jameson, Kate Muir, James Mottram, Aaron Eckhart, Aggie MacKenzie, Richard Hobson Deputy Cricket Correspondent, Anna Moore, Ed Potton, Suzy Jagger, Oliver Kay, Parminder Bahra Poverty and Development Correspondent, Trevor Johnston, Stephen Anderton, Monica Hayes, Sarah Vine, Mark Atherton, Lisa Armstrong, John Westerby, Patrick Hosking Banking and Finance Editor, Shimul Chaudhury, Rebecca O'connor Troubleshooter, Sandi Toksvig, Jane Wheatley, J. Hartley, Belinda Archer, Sam Coates, John Hopkins, Sally Baker, Gordon L. Clark, Neel Mukherjee, Pete Paphides, David Robertson Business Correspondent, Sheera Frenkel, Rob Wright, Celia Brayfield, John le Carré, Alex Spence, Raymond Keene, Adam Sage, Suzi Godson, Kate Saunders, Matt Hughes, Gordon Ramsay, Christine Buckley Industrial Editor, Sean O'Neill, Kaveh Solhekol, Roger Phillips, Jeremy Page, Rick Jones, Chris Campling, Alice Thomson, Stephen Plant, Patrick Hosking, Richard Owen, Gary Buchanan, Marcus Leroux, Roy Hyde, J. R. G. Edwards, Roger Boyes, Marcel Berlins, Erica Wagner, Alan Bennett, Aravind Adiga, John Matthew Bostock, James Charles, Nick Hasell, Sarah May, Lucy Powell, Denis MacShane, MP, Nell Fisher, David Hands Rugby Correspondent, Bernard Cooper, Tom Dart, Kevin Maher, Paul Simons, Bernadeta Tendyra, Michael Herman, Nicholas Clee, Nigel Kendall, Anne Ashworth, Nick Szczepanik, Dominic Kennedy, Joanna Pitman, Richard Ehrlich, Dr Matt Wyon, Brian Cattermole, Ian King Deputy Business Editor, Liz Hollis, Robert Crampton, Harriet Addison, Dominic Maxwell, Henrietta Klug, Roderick Strange, Matthew Parris, Mark Bridge, Prue White, Sophie Heawood, Amanda Craig, George Caulkin, Alan Franks, Russell Jenkins, Caitlin Moran, Sheila Keating, Neil Fisher, Iain Finlayson, Joe clay, Ben MacIntyre, Justin Kernoghan, Tim Teeman, Tony Dawe, Joe Clay, David Hutcheon, Jacqui Goddard, Jeremy Boot, John Naish, Catherine Philp, Martin Waller, Lewis Smith Environment Reporter, Valentine Low, Carl Mortished World Business Editor, Josephine Hart, Ashling O'Connor, Benedict Nightingale, Anna Shepard, Louise Cohen, Dina Behrman, Dr Thomas Stuttaford, Stephen Dalton, Nicola Woolcock, Leo Lewis, Brenda Enticknap, Bill Edgar, Richard Morrison, Tom Chesshyre, Tony Halpin, James Christopher, David Budworth, Simon Crompton, Dan Jog, Alan Lee Racing Correspondent, Alan Jackson, Owen Slot, Matt Roberts, Kim Newman, Alex Hardy, Will Hide, Leonora Weil, Fiona Hamilton, Jan Raath, Ann, David Robertson, Richard Ford, Annie Bell, Richard Beeston Foreign Editor,
... brilliant animation Film TV Comedy Batman and me Aaron Eckhart on starring in December's big DVD ...
2008 - Gale Group | TDA
... author on: Oxford Academic PubMed Google Scholar Aaron Klug Aaron Klug Medical Research Council, Laboratory of Molecular BiologyCambridge CB2 ...
Tópico(s): Protein Structure and Dynamics
1993 - Oxford University Press | Nucleic Acids Research
... zum biologischen Molekülverband (Nobel-Vortrag)† Prof. Dr. Aaron Klug, Prof. Dr. Aaron Klug Laboratory of Molecular Biology, Medical Research Council ... more papers by this author Prof. Dr. Aaron Klug, Prof. Dr. Aaron Klug Laboratory of Molecular Biology, Medical Research Council Centre ...
Tópico(s): ATP Synthase and ATPases Research
1983 - Wiley | Angewandte Chemie
... Macromolecules to Biological Assemblies (Nobel Lecture)† Prof. Dr. Aaron Klug, Corresponding Author Prof. Dr. Aaron Klug Laboratory of Molecular Biology, Medical Research Council Centre ... for more papers by this author Prof. Dr. Aaron Klug, Corresponding Author Prof. Dr. Aaron Klug Laboratory of Molecular Biology, Medical Research Council Centre ...
Tópico(s): Bacteriophages and microbial interactions
1983 - Wiley | Angewandte Chemie International Edition
Aaron Klug's group was one of the first to use a combination of X-ray diffraction and ...
Tópico(s): Plant Virus Research Studies
2004 - Elsevier BV | Trends in Cell Biology
In a Retrospective, [Professor Aaron Klug][1] recounts the remarkable accomplishments of his long-time colleague Max Perutz, who died last month at the age of ...
Tópico(s): History and advancements in chemistry
2002 - American Association for the Advancement of Science | Science
Page E. Klug, Aaron B. Shiels, Bryan M. Kluever, Jane Anderson, Steven C. Hess, Emily W. Ruell, William P. Bukoski, Shane R. Siers,
Invasive birds cause damage to economies, natural resources, and human safety across the globe.In the United States, rock doves (Columba livia), Eurasian collared doves (Streptopelia decaocto), rose-ringed parakeets (Psittacula krameri), monk parakeets (Myiopsitta monachus), common mynas (Acridotheres tristis), European starlings (Sturnus vulgaris), and house sparrows (Passer domesticus) are among the invasive and often harmful small-bodied birds inhabiting periurban habitats.The destructive nature of ...
Tópico(s): Wildlife Conservation and Criminology Analyses
2022 - Regional Euro-Asian Biological Invasions Centre (REABIC) | Management of Biological Invasions
... the 1960s and were concentrated in three groups: Aaron Klug's at the Laboratory of Molecular Biology of ...
Tópico(s): RNA modifications and cancer
2018 - Wiley | Angewandte Chemie International Edition
... 373Crossref PubMed Scopus (549) Google Scholar) (Figure 2A). Aaron Klug and colleagues solved the X-ray structure of ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Cell Press | Cell
... industry”. After studying Rosalind's notebooks, Nobel Laureate Aaron Klug, who had worked with Rosalind at Birkbeck, wrote ...
Tópico(s): Race, Genetics, and Society
2012 - Elsevier BV | The Lancet
Early influences led me first to medical school with a view to microbiology, but I felt the lack of a deeper foundation and changed to chemistry, which in turn led me to physics and mathematics. I moved to the University of Cape Town to work on the X-ray crystallography of some small organic compounds. I developed a new method of using molecular structure factors to solve the crystal structure, which won me a research studentship to Trinity College Cambridge and the Cavendish Laboratory. There I ...
Tópico(s): Plant Virus Research Studies
2010 - Annual Reviews | Annual Review of Biochemistry
... helical coiled-coils. Returning to England he joined Aaron Klug’s group at the newly founded Laboratory of ...
Tópico(s): Mechanical and Optical Resonators
2010 - Elsevier BV | Journal of Structural Biology
A long-standing goal of molecular biologists has been to construct DNA-binding proteins for the control of gene expression. The classical Cys2His2 (C2H2) zinc finger design is ideally suited for such purposes. Discriminating between closely related DNA sequences both in vitro and in vivo, this naturally occurring design was adopted for engineering zinc finger proteins (ZFPs) to target genes specifically. Zinc fingers were discovered in 1985, arising from the interpretation of our biochemical studies ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2010 - Cambridge University Press | Quarterly Reviews of Biophysics
An account is given of the discovery of the classical Cys 2 His 2 zinc finger, arising from the interpretation of biochemical studies on the interaction of the Xenopus protein transcription factor IIIA with 5S RNA, and of structural studies on its structure and its interaction with DNA. The finger is a self-contained domain stabilized by a zinc ion ligated to a pair of cysteines and a pair of histidines, and by an inner hydrophobic core. This discovery showed not only a new protein fold but also ...
Tópico(s): CRISPR and Genetic Engineering
2010 - Annual Reviews | Annual Review of Biochemistry
Yolanda Santiago, Edmond M. Chan, Peiqi Liu, Salvatore Orlando, Lin Zhang, Fyodor D. Urnov, Michael C. Holmes, Dmitry Guschin, Adam James Waite, Jeffrey C. Miller, Edward J. Rebar, Philip D. Gregory, Aaron Klug, Trevor N. Collingwood,
Gene knockout is the most powerful tool for determining gene function or permanently modifying the phenotypic characteristics of a cell. Existing methods for gene disruption are limited by their efficiency, time to completion, and/or the potential for confounding off-target effects. Here, we demonstrate a rapid single-step approach to targeted gene knockout in mammalian cells, using engineered zinc-finger nucleases (ZFNs). ZFNs can be designed to target a chosen locus with high specificity. Upon ...
Tópico(s): Plant Virus Research Studies
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Michal Minczuk, Monika Papworth, Jeffrey C. Miller, Michael P. Murphy, Aaron Klug,
The selective degradation of mutated mitochondrial DNA (mtDNA) molecules is a potential strategy to re-populate cells with wild-type (wt) mtDNA molecules and thereby alleviate the defective mitochondrial function that underlies mtDNA diseases. Zinc finger nucleases (ZFNs), which are nucleases conjugated to a zinc-finger peptide (ZFP) engineered to bind a specific DNA sequence, could be useful for the selective degradation of particular mtDNA sequences. Typically, pairs of complementary ZFNs are used ...
Tópico(s): RNA and protein synthesis mechanisms
2008 - Oxford University Press | Nucleic Acids Research
Since the classical C2H2 zinc finger motif was predicted in 1985,1 3% of the known and predicted genes in the human genome have been found encoding zinc finger proteins.2 Many structures have been reported of zinc finger–DNA interactions and show a common feature of zinc finger–DNA recognition. Zinc fingers read out the sequence information from the DNA major groove by forming specific hydrogen bonds between certain residues on the α-helix of zinc finger motif and the DNA bases.3 Most commonly, ...
Tópico(s): RNA modifications and cancer
2007 - Wiley | Proteins Structure Function and Bioinformatics
Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin R. Farlow, Aaron Klug, Bernardino Ghetti,
Work in 1980s and early 1990s established that the microtubule-associated protein tau is the major component of the paired helical filament of Alzheimer's disease. Similar filamentous deposits are also present in a number of other diseases, including progressive supranuclear palsy, corticobasal degeneration and Pick's disease. In 1998, the relevance of tau dysfunction for the neurodegenerative process became clear, when mutations in the tau gene were found to cause the inherited "frontotemporal dementia ...
Tópico(s): Prion Diseases and Protein Misfolding
2006 - IOS Press | Journal of Alzheimer s Disease
... Snelson's tensegrity structures. As Donald Caspar and Aaron Klug sought to extend the Crick-Watson theory of ...
Tópico(s): Utopian, Dystopian, and Speculative Fiction
2006 - American Phytopathological Society | Phytopathology
... else happened to be nearby. Participants randomly included Aaron Klug, Jim Watson, Hugh Huxley, Leslie Orgel, David Blow, ...
Tópico(s): RNA modifications and cancer
2006 - Wiley | Biochemistry and Molecular Biology Education
Michal Minczuk, Monika Papworth, Paulina Kolasinska, Michael P. Murphy, Aaron Klug,
We used engineered zinc finger peptides (ZFPs) to bind selectively to predetermined sequences in human mtDNA. Surprisingly, we found that engineered ZFPs cannot be reliably routed to mitochondria by using only conventional mitochondrial targeting sequences. We here show that addition of a nuclear export signal allows zinc finger chimeric enzymes to be imported into human mitochondria. The selective binding of mitochondria-specific ZFPs to mtDNA was exemplified by targeting the T8993G mutation, which ...
Tópico(s): Epigenetics and DNA Methylation
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Michel Goedert, Aaron Klug, R. Anthony Crowther,
In 1906, Alzheimer described the clinical and neuropathological characteristics of the disease that was subsequently named after him. Although the paired helical filament was identified as the major component of the neurofibrillary pathology of Alzhe
Tópico(s): Mitochondrial Function and Pathology
2006 - IOS Press | Journal of Alzheimer s Disease
An account is given of the discovery in 1985 of the classical Cys2His2 (C2H2) zinc finger, arising from the interpretation of biochemical studies on the interaction of the Xenopus protein transcription factor IIIA with 5S RNA, and of subsequent structural studies on its 3D structure and its interaction with DNA. Each finger constitutes a self-contained domain stabilized by a zinc ion ligated to a pair of cysteines and a pair of histidines, and by an inner structural hydrophobic core. This work showed ...
Tópico(s): DNA and Nucleic Acid Chemistry
2005 - Japan Academy | Proceedings of the Japan Academy Series B
... cloned the cDNA for TFIIIA from oocyte mRNA. Aaron Klug (60Miller J. McLachlan A.D. Klug A. EMBO ...
Tópico(s): Biocrusts and Microbial Ecology
2004 - Elsevier BV | Journal of Biological Chemistry