Koyamangalath Krishnan, S. Campbell, Fawzi Abdel-Rahman, Sarah Whaley, William L. Stone,
Cancer chemoprevention is a new approach in the management of cancer. Traditional cytotoxic chemotherapeutic approaches cannot cure most advanced solid malignancies. Chemoprevention can be defined as the use of non-cytotoxic drugs and natural agents to block the progression to invasive cancer. Chemoprevention can either prevent DNA damage that initiates the neoplastic transformation process or reverses the progression of pre-invasive lesions. Epidemiological observations, experimental evidence from ...
Tópico(s): Free Radicals and Antioxidants
2003 - Bentham Science Publishers | Current Drug Targets
Fawzi Abdel-Rahman, Ayad Ahmed Hussein, Riadh Rihani, O A Hlalah, Hani El Taani, Sujan Sharma, T.A.L. Nserat, Mahmoud Sarhan,
Tópico(s): Acute Lymphoblastic Leukemia research
2008 - Springer Nature | Bone Marrow Transplantation
Syed Osman Ahmed, Ardeshir Ghavamzadeh, Syed Ziauddin A. Zaidi, Helen Baldomero, Marcelo C. Pasquini, Fazal Hussain, Kamran Alimoghaddam, Fahad Almohareb, Mouhab Ayas, Amir Ali Hamidieh, Hossam K. Mahmoud, Alaa Elhaddad, Tarek Ben Othman, Abdelrahman Abdelkefi, Mahmoud Sarhan, Fawzi Abdel-Rahman, Salman Naseem Adil, Salam Alkindi, Ali Bazarbachi, Saïd Benchekroun, Dietger Niederwieser, Mary M. Horowitz, Aloïs Gratwohl, Hassan El Solh, Mahmoud Aljurf,
Hematopoietic stem cell transplantation (HSCT) activity was surveyed in the 9 countries in the World Health Organization Eastern Mediterranean region that reported transplantation activity. Between the years of 1984 and 2007, 7933 transplantations were performed. The number of HSCTs per year has continued to increase, with a plateau in allogeneic HSCT (allo-HSCT) between 2005 and 2007. Overall, a greater proportion of transplantations were allo-HSCT (n = 5761, 77%) compared with autologous HSCT (ASCT) ( ...
Tópico(s): T-cell and B-cell Immunology
2011 - Elsevier BV | Biology of Blood and Marrow Transplantation
Uwe Thiel, Angela Wawer, Petra Wolf, Manuela Badoglio, Annalisa Santucci, Thomas Klingebiel, Oliver Basu, Arndt Borkhardt, H.-J. Laws, Y Kodera, Ayami Yoshimi, Christina Peters, Ruth Ladenstein, Andrea Pession, Arcangelo Prete, Ernst-Christian Urban, Wolfgang Schwinger, Pierre Bordigoni, Alexandra Salmon, Miguel Ángel Díaz, Boris V. Afanasyev, Igor Lisukov, Еlena V. Morozova, Amos Toren, Bella Bielorai, J. Korsakas, Franca Fagioli, Desirée Caselli, Gerhard Ehninger, Bernd Gruhn, Uta Dirksen, Fawzi Abdel-Rahman, Massimo Aglietta, E. Mastrodicasa, Montserrat Torrent, Paolo Corradini, F Deméocq, Giorgio Dini, Peter Dreger, Matthias Eyrich, Jolanta Goździk, François Guilhot, Ernst Holler, Ewa Kościelniak, Chiara Messina, David Nachbaur, Roberto Sabbatini, Elena Oldani, Hellmut Ottinger, Hülya Özşahin, Rik Schots, Salvatore Siena, Joseph Allen Stein, Sabina Sufliarska, Ali Ünal, Marek Ussowicz, Pascale Schneider, Wilhelm Woessmann, H. Jürgens, Marco Bregni, Stefan Burdach,
BackgroundOutcomes of Ewing tumor (ET) patients treated with allogeneic stem cell transplantation (allo-SCT) were compared regarding the use of reduced-intensity conditioning (RIC) and high-intensity conditioning (HIC) regimens as well as human leukocyte antigen (HLA)-matched and HLA-mismatched grafts.Patients and methodsWe retrospectively analyzed data of 87 ET patients from the European Group for Blood and Marrow Transplantation, Pediatric Registry for Stem Cell Transplantations, Asia Pacific Blood ...
Tópico(s): Sarcoma Diagnosis and Treatment
2011 - Elsevier BV | Annals of Oncology
Riadh Rihani, Wail Hayajneh, Iyad Sultan, Lubna Ghatasheh, Fawzi Abdel‐Rahman, N. Hussein, Ayad Ahmed Hussein, Abdul Hadi Al‐Zaben, Mahmoud Sarhan, Mustafa Saad,
Tópico(s): Polyomavirus and related diseases
2011 - Springer Nature | Bone Marrow Transplantation
Said Mohamed, Ibtihal Fadhil, Rose-Marie Hamladji, Amir Ali Hamidieh, Omar Fahmy, Saloua Ladeb, Kamran Alimoghaddam, Alaa Elhaddad, Redhouane Ahmed Nacer, Fahad Alsharif, Walid Rasheed, Mohammad Jahani, Seyed Asadollah Mousavi, Amal Al-Seraihy, Fawzi Abdel-Rahman, Abdullah Al Jefri, Ayad Ahmed Hussein, Abdulaziz Alabdulaaly, Ahmad Ibrahim, Mohamed-Amine Bekadja, Miguel R. Abboud, Parvez Ahmed, David Dennison, Mohammad Bakr, Saïd Benchekroun, Fazal Hussain, Tarek Ben Othman, Mahmoud Aljurf, Ardeshir Ghavamzadeh,
BACKGROUND: The Eastern Mediterranean Bone Marrow Transplantation (EMBMT) Group has accumulated over 25 years of data and experience in hematopoietic stem cell transplantation (HSCT), most particularly in hemoglobinopathies, severe aplastic anemia (SAA), and inherited metabolic and immune disorders, in addition to hematologic malignancies peculiar to the region and where recent updates in trends in activities are warranted. OBJECTIVES: To study trends in HSCT activities in the World Health organization- ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2011 - Elsevier BV | Hematology/Oncology and Stem Cell Therapy
Imad Jaradat, Rasmi Mubiden, Ahmed Salem, Fawzi Abdel-Rahman, Iyad Al-Ahmad, Abdelatief Almousa,
BACKGROUND AND OBJECTIVES: In recent years, there has been an increasing role for stem cell transplantation In the management of retinoblastoma. The aim of this study was to systematically review the role high-dose chemotherapy followed by stem cell transplantation in the treatment of patients with metastatic or relapsed, trilateral or bilateral advanced retinoblastoma, and in patients with tumor at the surgical margin of the optic nerve and/or extrascleral extension. DESIGN: systematic literature ...
Tópico(s): Polyomavirus and related diseases
2012 - Elsevier BV | Hematology/Oncology and Stem Cell Therapy
Wafa M. Elbjeirami, Fawzi Abdel-Rahman, Ayad Ahmed Hussein,
Information regarding the probability of finding HLA-matched related donor for a patient awaiting hematopoietic stem cell transplantation (HSCT) in developing countries is scanty. We performed a retrospective review of HLA genotypes and related data for 1254 consecutive patients and their families at King Hussein Cancer Center in Amman, Jordan, between 2003 and 2011 to evaluate the chance of finding HLA-matched donor. The median family size was 5 for all patients in the study (range, 1-14), and the ...
Tópico(s): T-cell and B-cell Immunology
2012 - Elsevier BV | Biology of Blood and Marrow Transplantation
Walid Rasheed, Ardeshir Ghavamzadeh, Rose‐Marie Hamladji, Tarek Ben Othman, Amal Al-Seraihy, Fawzi Abdel-Rahman, Alaa Elhaddad, Abdulaziz Alabdulaaly, David Dennison, Ahmad Ibrahim, Ali Bazarbachi, Mohamed-Amine Bekadja, Said Mohamed, Salman Naseem Adil, Parvez Ahmed, Saïd Benchekroun, Mani Ramzi, Mohammad Jarrar, Kamran Alimoghaddam, Fazal Hussain, Amir Ali Hamidieh, Mahmoud Aljurf,
INTRODUCTION: This practice survey is conducted to analyze clinical hematopoietic stem cell transplantation (HSCT) practice variability among centers in the WHO Eastern Mediterranean Region (EMRO), as represented by the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group. METHOD: Th is internet based survey was completed by the medical program directors of the EMBMT centers; 17 centers participated. The survey collected data on various clinical aspects of HSCT practice. RESULTS: Consistency ...
Tópico(s): Mycobacterium research and diagnosis
2013 - Elsevier BV | Hematology/Oncology and Stem Cell Therapy
Ayad Ahmed Hussein, Abdulhadi Al‐Zaben, Lubna Ghatasheh, Abeer Natsheh, Tuka Hammada, Fawzi Abdel‐Rahman, Husam Abu‐Jazar, Shanta Sharma, Rula Najjar, Haydar Frangoul,
Abstract Background Patients with thalassemia in developing countries have limited access to safe transfusions, regular medical care and chelation therapy. Although allogeneic hematopoietic stem cell transplantation (HSCT) can offer a curative approach, there are limited data on the use of this procedure in developing countries. Procedure Forty‐four patients underwent a risk adopted HSCT from matched related family donor in Jordan. Thirty‐one patients (7 Class 1 and 24 Class 2) underwent myeloablative ...
Tópico(s): Prenatal Screening and Diagnostics
2013 - Wiley | Pediatric Blood & Cancer
Mahmoud Aljurf, Amr Nassar, Amir Ali Hamidieh, Alaa Elhaddad, Rose-Marie Hamladji, Ali Bazarbachi, Ahmed Ibrahim, Tarek Ben Othman, Fawzi Abdel-Rahman, Amal Al-Seraihy, Omar Fahmy, Ayad Ahmed Hussein, Abdulaziz Alabdulaaly, Salman Naseem Adil, Salam Alkindi, Mohamed Bayoumy, David Dennison, Mohamed Amine Bekadja, Ahmed Nacer Redhouane, Walid Rasheed, Ahmed AlSagheir, Reem Al‐Sudairy, Saloua Ladeb, Saïd Benchekroun, Mani Ramzi, Parvez Ahmed, Hassan El‐Solh, Syed Osman Ahmed, Fazal Hussain, Ardeshir Ghavamzadeh,
The Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group has accumulated over 31 years of data and experience in hematopoietic stem cell transplantation (HSCT), particularly in hemoglobinopathies, severe aplastic anemia, inherited metabolic and immune disorders, in addition to a wide array of hematologic malignancies unique to this region. A regional update in current HSCT trends is highly warranted. We studied the trends of HSCT activities in World Health Organization-Eastern Mediterranean ( ...
Tópico(s): Acute Lymphoblastic Leukemia research
2015 - Elsevier BV | Hematology/Oncology and Stem Cell Therapy
Giovanna Lucchini, Myriam Labopin, Eric Beohou, A Dalissier, Jean Hughes Dalle, Jacqueline Cornish, Marco Zecca, Sujith Samarasinghe, Brenda Gibson, Franco Locatelli, Yves Bertrand, Fawzi Abdel-Rahman, G. Socié, Mikael Sundin, Arjan C. Lankester, Peter Sedlacek, Rose Marie Hamladji, Carsten Heilmann, Boris V. Afanasyev, Rachel Hough, Christina Peters, Peter Bader, Paul Veys,
Hematopoietic stem cell transplantation (HSCT) represents the cornerstone of treatment in pediatric high-risk and relapsed acute myeloid leukemia (AML). The aim of the present study was to compare outcomes of pediatric patients with AML undergoing HSCT using 3 different conditioning regimens: total body irradiation (TBI) and cyclophosphamide (Cy); busulfan (Bu) and Cy; or Bu, Cy, and melphalan (Mel). In this retrospective study, registry data for patients > 2 and <18 years age undergoing matched allogeneic ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2016 - Elsevier BV | Biology of Blood and Marrow Transplantation
Haitham Tuffaha, Fawzi Abdel‐Rahman,
High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation is an important treatment option for a variety of malignancies. Peripheral blood stem cells (PBSCs) have replaced bone marrow-derived cells as source of stem cells in transplants, and the success of a transplant depends highly on the number of PBSCs mobilized, collected and eventually infused. Nevertheless, a good percentage of patients fail to mobilize stem cells when growth factors alone or in combination with ...
Tópico(s): Multiple Myeloma Research and Treatments
2010 - Elsevier BV | Hematology/Oncology and Stem Cell Therapy
Ali Bazarbachi, Myriam Labopin, Ardeshir Ghavamzadeh, Sebastian Giebel, Hayat E. Alzahrani, Saloua Ladeb, Giuseppe Leone, Fawzi Abdel-Rahman, Vincenzo Liso, Amir Ali Hamidieh, Walid Rasheed, Abdelrahman Ezzat, Abdulaziz Alabdulaaly, Sławomira Kyrcz‐Krzemień, R. Arnold, M A Kharfan-Dabaja, Kamran Alimoghaddam, Mahmoud Aljurf, Mohamad Mohty,
Tópico(s): Acute Lymphoblastic Leukemia research
2013 - Springer Nature | Bone Marrow Transplantation
Omar Ziad Alrawi, Fawzi Abdel-Rahman, Rula Alnajjar, Husam Abu‐Jazar, Mourad Salam, Mustafa Saad,
Cytomegalovirus (CMV) reactivation and infection are well-recognized complications after allogeneic stem cell transplantation (SCT). Only a few studies have addressed CMV reactivation after autologous SCT (ASCT).We retrospectively reviewed medical records of 210 adult patients who underwent ASCT for lymphoma or multiple myeloma (MM) at a single center from January 1(st), 2007 until December 31(st), 2012. All patients were monitored weekly with CMV antigenemia test till day 42 after transplantation, ...
Tópico(s): Herpesvirus Infections and Treatments
2015 - PAGEPress (Italy) | Mediterranean Journal of Hematology and Infectious Diseases
Khalid M. AlGhamdi, Maha Arafah, Luluah Al‐Mubarak, Amor Khachemoune, Fahad Alsaif,
... Scholar14. El-Darouti MA, Marzouk SA, Azzam O, Fawzi MM, Abdel-Halim MR, Zayed AA, et al. "Vitiligo vs. ...
Tópico(s): Nail Diseases and Treatments
2012 - King Faisal Specialist Hospital and Research Centre | Annals of Saudi Medicine
Rawad Rihani, Isam Lataifeh, Hadeel Halalsheh, Ayad Ahmed Hussein, Abdulhadi Al‐Zaben, Fawzi Abdel‐Rahman, Mahmoud Sarhan,
A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stem cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT. A sustained hematological engraftment was achieved at 9 days post-second HSCT. At 15 months post-second HSCT; the patient demonstrated normal ...
Tópico(s): Prenatal Screening and Diagnostics
2010 - Wiley | Pediatric Blood & Cancer
Hikmat Abdel‐Razeq, Fawzi Abu Rous, Fawzi Abuhijla, Nayef Abdel-Razeq, Sarah Edaily,
Breast cancer is the most common cancer diagnosed among women worldwide and more than half are diagnosed above the age of 60 years. Life expectancy is increasing and the number of breast cancer cases diagnosed among older women are expected to increase. Undertreatment, mostly due to unjustifiable fears of advanced-age and associated comorbidities, is commonly practiced in this group of patients who are under-represented in clinical trials and their management is not properly addressed in clinical ...
Tópico(s): Cancer Treatment and Pharmacology
2022 - Dove Medical Press | Clinical Interventions in Aging
H El Derea, Edward Salem, Mohamed Fawzi, M Abdel Azeem,
We assessed the food safety knowledge and food handling practices of 23 food handlers in 2 hospitals in Alexandria, Egypt [Gamal Abdel Nasser (GAN) and Medical Research Institute (MRI)] before and after a food safety training programme, and also the bacteriological quality of patient meals and kitchen equipment. There was a significant improvement in all knowledge-associated parameters except for personal hygiene in GAN. There was an improvement in the food safety practices in both hospitals. The bacteriological ...
Tópico(s): Food Safety and Hygiene
2009 - World Health Organization | Eastern Mediterranean Health Journal
MA El Darouti, Salah F Hussein, SR Al Tahlawy, M Al Fangary, HM Mashaly, Eman El Nabarawy, A Al Tawdy, May Fawzi, Rania Abdel Hay,
Nail changes in leprotic patients are not specific to leprosy, and may be observed in other peripheral neuropathies. Diabetes is one of the diseases that present with nail dystrophy secondary to peripheral neuropathy, vasculopathy, trauma and infections. Therefore, nail changes in diabetic neuropathy are expected to be very similar to that of leprosy.To evaluate the frequency and pattern of nail changes in Egyptian leprotic patients with the different spectrums of the disease, and to compare nail ...
Tópico(s): Nail Diseases and Treatments
2010 - Wiley | Journal of the European Academy of Dermatology and Venereology
Isam Anabtawi, Fawzi Abdel-Rahman, M. Al Masri,
Abstract Background Surgical complications in recipients of hematopoietic stem cell transplantation (HSCT) are common. However, this issue is infrequently reported in the literature. Methods The records of 165 patients who underwent hematopoietic stem cell transplantation at King Hussein Cancer Center between January 2007 and December 2008 were retrospectively reviewed. All surgical complications were included and were classified into gastrointestinal (GI), catheter-related, ear, nose and throat (ENT), peri ...
Tópico(s): Oral health in cancer treatment
2011 - Elsevier BV | European Journal of Surgical Oncology
Amr Rateb, Marwa M. Fawzi, Rania Abdel Hay, Faissal N Mohammed, Khalda Amr,
The regulated upon activation, normal T cell expressed and secreted (RANTES) production in psoriatic lesions may amplify the inflammation in these lesions. Narrow band ultraviolet B (NB-UVB), a therapeutic modality for psoriasis, affects the expression of inflammatory cytokines and chemokines.Our aim was to evaluate RANTES mRNA expression in skin lesions of psoriasis before and after NB-UVB phototherapy.This study included 25 psoriatic patients who received 24 sessions of NB-UVB. Skin biopsies were ...
Tópico(s): Photodynamic Therapy Research Studies
2012 - John Libbey Eurotext | European Journal of Dermatology
Waleed Fawzi, Mohamed Yousry Abdel Mohsen, Abdel Hamid Hashem Hashem, Suaad Moussa, Elizabeth Coker, Kenneth Wilson,
ABSTRACT Background: Adherence to treatment is a complex and poorly understood phenomenon. This study investigates the relationship between older depressed patients’ adherence to antidepressants and their beliefs about and knowledge of the medication. Methods: Assessment was undertaken of 108 outpatients over the age of 55 years diagnosed with depressive disorder and treated for at least four weeks with antidepressants. Adherence was assessed using two self-report measures: the Medication Adherence ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2011 - Cambridge University Press | International Psychogeriatrics
Saleh Hammad, Manal Alnammourah, Farah Almahmoud, Mais Fawzi, Abdel-Hadi Breizat,
The subject of organs for transplant after brain death raises many concerns, including definition and timing of death, how to permit human organ transplant, and the idea of paying for organs. Many ethical concerns are raised regarding regulations and procedures for organ transplant in developing countries. These include where and how to obtain organs and the concept of justice in organ distribution.We administered 2682 questionnaires to 628 men and 2054 women over 24 months (range, 18 to 70 years ...
Tópico(s): Palliative Care and End-of-Life Issues
2017 - Başkent University | Experimental and Clinical Transplantation
Hoda Rasheed, Marwa M. Fawzi, Mona R. E. Abdel‐Halim, Amal M. Eissa, Nahla Mohammed Salem, Soheir Mahfouz,
Matrix metalloproteinase-9 (MMP-9) has been correlated with poor clinical outcome in various malignancies and is associated with enhanced tumor growth and dissemination through its role in angiogenesis. This study was carried out to review the immunohistological staining of MMP-9 in skin lesions of different stages of mycosis fungoides (MF). The study was carried on 22 patients with MF and 10 healthy controls. Immunohistochemical staining using MMP-9 monoclonal anti-human antibodies was performed ...
Tópico(s): Cell Adhesion Molecules Research
2010 - Lippincott Williams & Wilkins | American Journal of Dermatopathology
Issa M. El‐Nahhal, Shehata M. Zourab, Fawzi S. Kodeh, Fatma H. Abdel‐Salam,
Tópico(s): Analytical Chemistry and Chromatography
2014 - Springer Science+Business Media | Journal of Sol-Gel Science and Technology
Mounir H. Fawzi, Maggie M. Fawzi, Nagwa S. Said, Mohab M. Fawzi, Amira Fouad, Hanaa Abdel-Moety,
Ramadan fasting is believed to be beneficial. We assessed a random sample of 100 Egyptian male schizophrenia outpatients using the Positive and Negative Syndrome Scale (PANSS) and dietary, anthropometric, clinical, and laboratory measures at baseline (T1) before Ramadan of 2014 and during the fourth week of Ramadan (T2). The metabolic syndrome was identified in 31 patients and these showed a reduction of high-density lipoprotein cholesterol (HDLc) and brain-derived neurotrophic factor (BDNF) concentrations ...
Tópico(s): Regulation of Appetite and Obesity
2014 - Elsevier BV | Psychiatry Research
Randa Mohamed Zaki, Adel A. Ali, Shahira Fawzi El Menshawi, Ahmed Abdel Bary,
The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. The present investigation is an attempt to improve the solubility and dissolution rate of diacerein (a poorly soluble drug) by solid dispersion technique. Binary solid dispersions were made using PEG-4000 or PEG-6000 as carriers with varying drug: carrier ratios 1:1, 1:3 and 1:5. Also ternary solid dispersions were made using PEG-4000 and Pluronic F-68 ...
Tópico(s): Pharmacological Effects of Natural Compounds
2013 - | International Journal of Drug Delivery
Fawzi Abdel-Rahman, Haitham Tuffaha, Shanta Sharma, Husam Abu Jazar, Nilly Hussein, Adnan Saad, Omar Al Rawi, Ayad Ahmed Hussein,
Introduction Plerixafor is a novel mobilizing agent of peripheral blood stem cells (PBSCs) in lymphoma and multiple myeloma (MM) patients whose cells mobilize poorly. Due to the substantial cost associated with its use, we aimed to compare the effectiveness and cost effectiveness of Plerixafor + GCSF (PG) versus GCSF ± Chemotherapy (GC) as salvage mobilization regimens. Methods The charts of consecutive lymphoma and MM patients who had undergone at least one previous attempt of PBSCs mobilization that failed ...
Tópico(s): Acute Myeloid Leukemia Research
2013 - SAGE Publishing | Journal of Oncology Pharmacy Practice
Fawzi Abdel-Rahman, Ayad Ahmed Hussein, Mohammad Aljamily, Abdulhadi Al‐Zaben, Nilly Hussein, Alaa Addasi,
Purpose . to evaluate the outcome of patients with Hodgkin’s lymphoma who underwent autologous transplantation at KHCC bone marrow transplant program. Patients and Methods . Over 6 years, 63 patients with relapsed or refractory Hodgkin’s lymphoma underwent high dose chemotherapy followed by autologous transplant. There were 25.4% patients in complete remission (CR), 71.4% with chemotherapy responsive disease at the time of transplant. Prior to conditioning regimen, 56% received two chemotherapy lines, ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2012 - Hindawi Publishing Corporation | ISRN Oncology