Akihito Hashidzume, Junya Shiota, Yusuke Ueno, Tetsuya Noda, Yoshinori Takashima, Akira Harada, Mikiharu Kamachi,
Abstract Acetaldehyde azine (AcAz) underwent ‘crisscross’ addition with two equivalents of phenyl isocyanate to form a one-to-two adduct in a moderate yield (63.0%). Using crisscross addition of AcAz, polymeric products were obtained from AcAz and 1,4-phenylene diisocyanate in a high ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2005 - Elsevier BV | Polymer
Estefanía Acaz‐Fonseca, Ana Ortiz‐Rodriguez, Íñigo Azcoitia, Luis Miguel García‐Segura, María‐Ángeles Arévalo,
In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored the role of Notch activity on the morphological reactivity of primary astrocytes in response to LPS, an inflammatory stimulus. We found that LPS induces reactive astrocyte morphology by the inhibition of Notch signaling via NFκB activation and Jagged upregulation. ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2019 - Springer Nature | Cell Death Discovery
María‐Ángeles Arévalo, Isabel Ruiz-Palmero, M. Julia Scerbo, Estefanía Acaz‐Fonseca, María Julia Cambiasso, Luis Miguel García‐Segura,
This review analyzes the signaling mechanisms activated by estradiol to regulate neuritogenesis in several neuronal populations. Estradiol regulates axogenesis by the activation of the mitogen activated protein kinase (MAPK) cascade through estrogen receptor α located in the plasma membrane. In addition, estradiol regulates MAPK signaling via the activation of protein kinase C and by increasing the expression of brain derived neurotrophic factor and tyrosine kinase receptor B. Estradiol also interacts ...
Tópico(s): Nuclear Receptors and Signaling
2011 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
María Santos‐Galindo, Estefanía Acaz‐Fonseca, María José Bellini, Luis Miguel García‐Segura,
Numerous neurological and psychiatric disorders show sex differences in incidence, age of onset, symptomatology or outcome. Astrocytes, one of the glial cell types of the brain, show sex differences in number, differentiation and function. Since astrocytes are involved in the response of neural tissue to injury and inflammation, these cells may participate in the generation of sex differences in the response of the brain to pathological insults. To explore this hypothesis, we have examined whether ...
Tópico(s): Immune Response and Inflammation
2011 - BioMed Central | Biology of Sex Differences
Elisabetta De Marinis, Estefanía Acaz‐Fonseca, María‐Ángeles Arévalo, Paolo Ascenzi, Marco Fiocchetti, Maria Marino, Luis Miguel García‐Segura,
Neuroglobin (Ngb), so named after its initial discovery in brain neurones, has received great attention as a result of its neuroprotective effects both in vitro and in vivo . Recently, we demonstrated that, in neurones, Ngb is a 17β‐oestradiol (E 2 ) inducible protein that is pivotal for hormone‐induced anti‐apoptotic effects against H 2 O 2 toxicity. The involvement of Ngb in other brain cell populations, as well as in other neuroprotective effects of E 2 , is completely unknown at present. We demonstrate ...
Tópico(s): Neuropeptides and Animal Physiology
2012 - Wiley | Journal of Neuroendocrinology
María‐Ángeles Arévalo, María Santos‐Galindo, Estefanía Acaz‐Fonseca, Íñigo Azcoitia, Luis Miguel García‐Segura,
This article is part of a Special Issue "Hormones & Neurotrauma". Astrocytes and microglia respond to central nervous system (CNS) injury with changes in morphology, proliferation, migration and expression of inflammatory regulators. This phenomenon is known as reactive gliosis. Activation of astrocytes and microglia after acute neural insults, such as stroke or traumatic CNS injury, is considered to be an adaptive response that contributes to minimize neuronal damage. However, reactive gliosis may ...
Tópico(s): Neuroscience and Neuropharmacology Research
2012 - Elsevier BV | Hormones and Behavior
Murat Türköz, Hasan Savaş, Aykut Acaz, Hasan Tosun,
Because expansive and dispersive soils damage engineering structures, extensive studies on using additives to ameliorate the effects of these soils have been conducted. In this study, the effect of magnesium chloride (MgCl2) solution on the engineering properties of clay soils was evaluated. Previous studies on this subject have shown that MgCl2 is more commonly used as an anti-icing agent on roads than as a soil stabilizer. MgCl2 is also used to control dust and humidity on roads and to reduce the ...
Tópico(s): Geotechnical and construction materials studies
2014 - Elsevier BV | Applied Clay Science
Estefanía Acaz‐Fonseca, Rebeca Sánchez‐González, Íñigo Azcoitia, María‐Ángeles Arévalo, Luis Miguel García‐Segura,
Neuroprotective actions of 17β-estradiol (estradiol) are in part mediated by direct actions on neurons. Astrocytes, which play an essential role in the maintenance of the homeostasis of neural tissue, express estrogen receptors and are also involved in the neuroprotective actions of estradiol in the brain. Estradiol controls gliosis and regulates neuroinflammation, edema and glutamate transport acting on astrocytes. In addition, the hormone regulates the release of neurotrophic factors and other ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2014 - Elsevier BV | Molecular and Cellular Endocrinology
Produção Nacional
Revisado por pares
Glauco Alves Pereira, Sidnei de Melo Dantas, Luís Fábio Silveira, Sônia Aline Roda, Ciro Albano, Frederico Acaz Sonntag, Sérgio Roberto Moura Leal, Maurício Cabral Periquito, Gustavo Bernardino Malacco, Alexander Charles Lees,
The Atlantic Forest of northeast Brazil hosts a unique biota which is among the most threatened in the Neotropics. Near-total conversion of forest habitat to sugar cane monocultures has left the region's endemic forest-dependent avifauna marooned in a few highly-fragmented and degraded forest remnants. Here we summarise the current status of 16 globally threatened species based on surveys conducted over the last 11 years. We found a bleak situation for most of these species and consider that three ...
Tópico(s): Species Distribution and Climate Change
2014 - UNIVERSIDADE DE SÃO PAULO | Papéis Avulsos de Zoologia
Daniela Grassi, María José Bellini, Estefanía Acaz‐Fonseca, Giancarlo Panzica, Luis Miguel García‐Segura,
Abstract The expression of arginine-vasopressin (AVP) is regulated by estradiol and testosterone (T) in different neuronal populations by mechanisms that are not yet fully understood. Estrogen receptors (ERs) have been shown to participate in the regulation of AVP neurons by estradiol. In addition, there is evidence of the participation of ERβ in the regulation of AVP expression exerted by T via its metabolite 5α-dihydrotestosterone (5α-DHT) and its further conversion in the androgen metabolite and ...
Tópico(s): Circadian rhythm and melatonin
2013 - Oxford University Press | Endocrinology
Mariana Astiz, Estefanía Acaz‐Fonseca, Luis Miguel García‐Segura,
Tópico(s): Stress Responses and Cortisol
2013 - Springer Science+Business Media | Neurotoxicity Research
Ana Belén López-Rodríguez, Estefanía Acaz‐Fonseca, Silvia Giatti, Donatella Caruso, María‐Paz Viveros, Roberto Cosimo Melcangi, Luis Miguel García‐Segura,
Tópico(s): Anesthesia and Neurotoxicity Research
2015 - Elsevier BV | Psychoneuroendocrinology
Estefanía Acaz‐Fonseca, Juan Carlos Durán, Paloma Carrero, Luis Miguel García‐Segura, María‐Ángeles Arévalo,
Several brain disorders associated with neuroinflammation show sex differences in their incidence, onset, progression and/or outcome. The different regulation of the neuroinflammatory response in males and females could underlie these sex differences. In this study, we have explored whether reactive gliosis after a penetrating cortical injury exhibits sex differences. Males presented a higher density of Iba1 immunoreactive cells in the proximity of the wound (0-220 μm) than females. This sex difference ...
Tópico(s): Alzheimer's disease research and treatments
2015 - Wiley | Glia
Ana Belén López-Rodríguez, Estefanía Acaz‐Fonseca, María‐Paz Viveros, Luis Miguel García‐Segura,
Traumatic brain injury (TBI) incidence rises during adolescence because during this critical neurodevelopmental period some risky behaviors increase. The purpose of this study was to assess the contribution of cannabinoid receptors (CB1 and CB2), blood brain barrier proteins (AQP4) and astrogliosis markers (vimentin) to neurological deficit and brain edema formation in a TBI weight drop model in adolescent male mice. These molecules were selected since they are known to change shortly after lesion. ...
Tópico(s): Neuroscience of respiration and sleep
2015 - Public Library of Science | PLoS ONE
Ana Belén López-Rodríguez, Virginia Mela, Estefanía Acaz‐Fonseca, Luis Miguel García‐Segura, María‐Paz Viveros,
The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16kDa peptidic hormone is mainly known as a regulator of energy balance and has been shown to exert neuroprotective effects in different models of brain pathology. In this study, we have assessed whether leptin exerts protective actions in a TBI mouse model. In addition, the possible implication of CB2 cannabinoid ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2016 - Elsevier BV | Experimental Neurology
Estefanía Acaz‐Fonseca, Marco Ávila-Rodriguez, Luis Miguel García‐Segura, George E. Barreto,
In the last years there has been a considerable advance in the knowledge on the regulation of astrocytes by sex steroids under physiological and pathological conditions. By the activation of a variety of nuclear and membrane receptors, sex steroid hormones regulate the functions of astrocytes and their communication with other cell types in the central nervous system. Under physiological conditions astrocytes participate in the neuroendocrine and behavioral actions of gonadal steroids, as well as ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2016 - Elsevier BV | Progress in Neurobiology
Ana Belén López-Rodríguez, Estefanía Acaz‐Fonseca, Roberto Spezzano, Silvia Giatti, Donatella Caruso, María‐Paz Viveros, Roberto Cosimo Melcangi, Luis Miguel García‐Segura,
The incidence of traumatic brain injuries (TBIs) in humans has rapidly increased in the last ten years. The most common causes are falls and car accidents. Approximately 80 000-90 000 persons per year will suffer some permanent disability as a result of the lesion, and one of the most common symptoms is the decline of hormone levels, also known as post-TBI hormonal deficiency syndrome. This issue has become more and more important, and many studies have focused on shedding some light on it. The hormonal ...
Tópico(s): Neonatal and fetal brain pathology
2016 - Oxford University Press | Endocrinology
Estefanía Acaz‐Fonseca, Ana Ortiz‐Rodriguez, Ana Belén López-Rodríguez, Luis Miguel García‐Segura, Mariana Astiz,
Abstract Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC) of male and female mice during early postnatal life, when sex steroids induce sex-dimorphic maturation of the brain. Despite the fact that total amount of CL was similar, its fatty acid composition differed between males and females at birth. In ...
Tópico(s): ATP Synthase and ATPases Research
2017 - Nature Portfolio | Scientific Reports
Ana Ortiz‐Rodriguez, Estefanía Acaz‐Fonseca, Patricia Boya, María‐Ángeles Arévalo, Luis Miguel García‐Segura,
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2018 - Springer Science+Business Media | Molecular Neurobiology
Mikiharu Kamachi, Atsushi Kajiwara, Akihito Hashidzume, Kentaro Matsuda, Akira Harada,
... obtain high-molecular-weight polymers from acetaldehyde azine (AcAz), anionic polymerization was investigated under various conditions. Polymerizations of AcAz initiated by methylmagnesium iodide yielded high-molecular-weight ... of 1,4-trans units. In addition, poly(AcAz) was crystalline and fully decomposed below 280°C.
Tópico(s): Structural and Chemical Analysis of Organic and Inorganic Compounds
2004 - Taylor & Francis | Designed Monomers & Polymers
Daniela Grassi, Samar Ghorbanpoor, Estefanía Acaz‐Fonseca, Isabel Ruiz-Palmero, Luis Miguel García‐Segura,
The selective estrogen receptor modulator raloxifene reduces blood pressure in hypertensive postmenopausal women. In the present study we have explored whether raloxifene regulates gene expression of arginine vasopressin (AVP), which is involved in the pathogenesis of hypertension. The effect of raloxifene was assessed in human female SH-SY5Y neuroblastoma cells, which have been recently identified as a suitable cellular model to study the estrogenic regulation of AVP. Raloxifene, within a concentration ...
Tópico(s): Estrogen and related hormone effects
2015 - Oxford University Press | Endocrinology
Estefanía Acaz‐Fonseca, María Castelló‐Ruiz, Marı́a C. Burguete, Alicia Aliena‐Valero, Juan B. Salom, Germán Torregrosa, Luis Miguel García‐Segura,
Including sex is of paramount importance in preclinical and clinical stroke researches, and molecular studies dealing in depth with sex differences in stroke pathophysiology are needed. To gain insight into the molecular sex dimorphism of ischaemic stroke in rat cerebral cortex, male and female adult rats were subjected to transient middle cerebral artery occlusion. The expression of neuroglobin (Ngb) and other functionally related molecules involved in sex steroid signalling (oestrogen and androgen ...
Tópico(s): Hormonal and reproductive studies
2020 - Wiley | European Journal of Neuroscience
Estefanía Acaz‐Fonseca, Ana Ortiz‐Rodriguez, Luis Miguel García‐Segura, Mariana Astiz,
Abstract Cardiolipin ( CL ) is a phospholipid that is almost exclusively located in the inner mitochondrial membrane of eukaryotic cells. As a result of its unique structure and distribution, CL establishes non‐covalent bonds with a long list of proteins involved in ATP production, mitochondria biogenesis, mitophagy and apoptosis. Thus, the amount of CL, as well as its fatty acid composition and location, strongly impacts upon mitochondrial‐dependent functions and therefore the metabolic homeostasis ...
Tópico(s): ATP Synthase and ATPases Research
2019 - Wiley | Journal of Neuroendocrinology
María‐Ángeles Arévalo, Isabel Ruiz-Palmero, Julia Simon‐Areces, Estefanía Acaz‐Fonseca, Íñigo Azcoitia, Luis Miguel García‐Segura,
The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in developing hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30. This interaction is relevant for the ...
Tópico(s): Developmental Biology and Gene Regulation
2011 - Frontiers Media | Frontiers in Endocrinology
Akihito Hashidzume, Tetsuya Noda, Yotaro Morishima, Atsushi Kajiwara, Mikiharu Kamachi,
... was obtained by the reaction between acetaldehyde azine (AcAz) and maleic anhydride (MAnh) without any initiator. The ... values for this product indicate polymer formation from AcAz and MAnh. Results of the reactions between AcAz and MAnh at varying feed ratios of AcAz indicate that the polymer is formed mainly by reaction between equimolar amounts of AcAz and MAnh. (2Z)-4-{1-(5-Methyl-2- ... compound 1), a one-to-one adduct of AcAz with MAnh, was isolated as a crystalline compound ... compound 2), a one-to-one adduct of AcAz with SAnh, the polymer from AcAz and MAnh ...
Tópico(s): Supramolecular Chemistry and Complexes
2000 - American Chemical Society | Macromolecules
Julia Simon‐Areces, Estefanía Acaz‐Fonseca, Isabel Ruiz-Palmero, Luis Miguel García‐Segura, María‐Ángeles Arévalo,
Neurogenin 3 (Ngn3), a proneural gene, regulates dendritogenesis and synaptogenesis in mouse hippocampal neurons. Ngn3 is transiently exported from the cell nucleus to the cytoplasm when neuronal polarity is initiated, suggesting that the nucleo-cytoplasmic transport of the protein is important for its action on neuronal development. In this study, we identified for the first time a functional nuclear export sequence (NES2; 131YIWALTQTLRIA142) in Ngn3. The green fluorescent protein (EGFP)-NES2 fusion ...
Tópico(s): Microtubule and mitosis dynamics
2013 - Public Library of Science | PLoS ONE
Lin Ying, Qian Shi, Junhong Yang, Guowei Huang, Jing Yan,
... 97 (upper arm circumference for age z score [ACAZ]), and −0.14 ± 1.00 (triceps skinfold thickness ... respiratory and extrapulmonary complication group had a lower ACAZ (OR = 0.674; 95% CI = 0.469–0. ... CI = 0.389–0.843; P < 0.05). ACAZ ( β = −0.368; 95% CI = −0.720 to ... 0.05) were negatively correlated with LOS. Conclusion ACAZ and TSAZ were associated with complications and LOS ...
Tópico(s): Respiratory Support and Mechanisms
2023 - Wiley | Nutrition in Clinical Practice
Luis Miguel García‐Segura, Íñigo Azcoitia, George E. Barreto,
... Arevalo et al., 2010; Johann and Beyer, 2013; Acaz-Fonseca et al., 2014). Thus, estradiol acts on ... stress, beta-amyloid toxicity and experimental stroke. References Acaz-Fonseca, E., Sanchez-Gonzalez, R., Azcoitia, I., Arevalo, ... vitro. Glia 58, 93-102. De Marinis, E. Acaz-Fonseca, E., Arevalo, M.A., Ascenzi, P., Fiocchetti, ...
Tópico(s): Estrogen and related hormone effects
2015 - Frontiers Media | Frontiers in Cellular Neuroscience
Produção Nacional
Maria Iranilda Silva Magalhães, Adélcio Machado dos Santos, Lívia Barbosa Pacheco Souza, Miriam de Andrade Brandão, Vitória Vilas Boas da Silva Bomfim, Acaz Petrus Soares,
O artigo "Educação em Saúde como Principal Alternativa para Promover a Saúde do Idoso" explora a importância da educação em saúde como uma estratégia fundamental para promover o bem-estar e a qualidade de vida dos idosos. O objetivo do estudo é destacar os benefícios da educação em saúde, sua relação com a adesão a práticas saudáveis e o impacto na busca por cuidados médicos adequados. O artigo ressalta que a educação em saúde capacita os idosos a adquirir conhecimentos relevantes sobre sua saúde, ...
Tópico(s): Physical Education and Gymnastics
2023 - Arche Scientific and Editorial Consultancy | Revista Ibero-Americana de Humanidades, Ciências e Educação