D O Gibbons, AF Lant, A. Ashford, R F Collins, Sophie C. Pinder,
... 2 The inhibitory effects of varying concentrations of acebutolol, practolol and propranolol on free fatty acid (FFA) ... fat cells prepared from rat epididymal adipose tissue. Acebutolol and practolol, at equimolar concentrations, showed a similar ... virtually abolished whilst at the same molar concentration, acebutolol and practolol halved the response. 3 Six healthy ... given either after single oral doses of placebo, acebutolol or practolol. The mean (+/‐ s.e. mean) basal ... beta‐adrenoceptor blocker were not significantly different. 4 Acebutolol inhibited the respective mean rises in FFA, produced ...
Tópico(s): Pharmacological Effects and Assays
1976 - Wiley | British Journal of Clinical Pharmacology
CR Kumana, Monica Leighton, C M Kaye, Paul Turner, John Hamer,
... mg. per kg.), practolol (1 mg. per kg.), acebutolol (1 mg. per kg.), or placebo were each ... significance. At 2, 3, and 4 hours when acebutolol and propranolol produced equivalent cardiac β-blocking activity ( ... 1; and at 2 hours when practolol and acebutolol gave rise to almost equivalent cardiac β blockade, ... R. after propranolol (but not after practolol or acebutolol) were significantly greater than the corresponding changes after ... P.F.R. after propranolol (6 hours) and acebutolol (4 hours) (but not after practolol) were significantly ...
Tópico(s): Anesthesia and Pain Management
1975 - Elsevier BV | The Lancet
Wilbert S. Aronow, Steven Van Camp, Marvin Turbow, Kenneth Whittaker, Mark Lurie,
The effect of intravenous acebutolol on supraventricular arrhythmias was evaluated in 20 patients, 5 with chronic obstructive pulmonary disease. A rapid ventricular rate in atrial ... than 15% in all of 10 patients by acebutolol and in none of 5 patients by saline. ... than 15% in all of 6 patients by acebutolol and in none of 3 patients by saline. ... than 75% in each of 2 patients by acebutolol and not in a patient by saline. Acebutolol converted multifocal atrial tachycardia to sinus rhythm in ... not affected by saline but was abolished by acebutolol in a patient. Acebutolol was well tolerated in ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1979 - Wiley | Clinical Pharmacology & Therapeutics
Steven Singh, Robert DiBianco, Michael Davidov, John S. Gottdiener, W L Johnson, Atul Laddu, Ross D. Fletcher,
HomeCirculationVol. 65, No. 7Comparison of acebutolol and propranolol for treatment of chronic ventricular arrhythmia: a placebo-controlled, double-blind, randomized crossover study. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd ... ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBComparison of acebutolol and propranolol for treatment of chronic ventricular arrhythmia: ... 1994. O'Reilly M (1991) Chronic use of acebutolol in the treatment of cardiac arrhythmias, American Heart ...
Tópico(s): Cardiac Arrhythmias and Treatments
1982 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
Robert DiBianco, Steven Singh, Pankaj Shah, G C Newton, Robert R. Miller, Patricia A. Nahormek, Rebecca B. Costello, Atul Laddu, John S. Gottdiener, Ross D. Fletcher,
... 65, No. 6Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo- ... toFree AccessAbstractPDF/EPUBComparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo- ... Smith E and Weidler D (2013) Low-Dose Acebutolol Given Once Daily in the Treatment of Chronic ... Singh B, Thoden W and Wahl J (2012) Acebutolol: A Review of its Pharmacology, Pharmacokinetics, Clinical Uses, ... date: 4-Mar-1986. de Soyza N (1985) Acebutolol for premature ventricular contractions: Short- and long-term ...
Tópico(s): Meta-analysis and systematic reviews
1982 - Lippincott Williams & Wilkins | Circulation
Two double-blind multicenter studies compared acebutolol with placebo (acebutolol, N = 121; placebo, N = 116) and with propranolol (acebutolol, N = 186; propranolol, N = 190) in essential hypertension. Acebutolol significantly reduced mean sitting diastolic blood pressure from ... of dose titration (p = 0.001). Significantly more acebutolol patients (65%) achieved therapeutic goal than did placebo ... 0.01). The reduction in heart rate in acebutolol-treated patients (9.2 bpm) was greater than ... of side effects did not significantly differ between acebutolol and placebo. Acebutolol and propranolol produced comparable reductions ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
1985 - Elsevier BV | American Heart Journal
A. S. Turner, Joan C. Brocklehurst,
Acebutolol was compared to atenolol in 33 patients with mild to moderate essential hypertension (diastolic blood pressure > ... crossover study design. At 8 weeks of treatment, acebutolol, 400 mg once daily, and atenolol, 100 mg ... also significantly reduced (p < 0.01) from baseline (acebutolol, 14.8%; atenolol, 18.3%); the reduction with acebutolol, however, was significantly less (p < 0.05) than ... effects during exercise, and serum drug determinations showed acebutolol to be rapidly metabolized. Acebutolol appeared to be ...
Tópico(s): Analytical Methods in Pharmaceuticals
1985 - Elsevier BV | American Heart Journal
Janice Wahl, Prasad Turlapaty, Bramah N. Singh,
A multicenter, double-blind study compared oral acebutolol (n = 186) with propranolol (n = 190) in the treatment of mild to moderately severe essential hypertension (diastolic ≥95 to 129 mm Hg). Both ... blood pressures of 16%, 12%, and 14% on acebutolol and 15%, 12%, and 14% on propranolol (all p < 0.01). At equipotent, antihypertensive doses, acebutolol induced significantly less reduction in resting heart rate than propranolol (13% on acebutolol, 17% on propranolol, p = 0.02). The mean effective doses of acebutolol and propranolol were 738 mg and 231 mg, ...
Tópico(s): Heart rate and cardiovascular health
1985 - Elsevier BV | American Heart Journal
Patrick Daudon, Thierry Corcos, I Gandjbakhch, J. P. Levasseur, Annik Cabol, C Cabrol,
... may have deleterious hemodynamic consequences. To determine if acebutolol, a cardioselective β-blocking drug, prevents such tachyarrhythmias ... day), 50 patients were given 200 mg of acebutolol (or 400 mg if weight was more than ... patients atrial flutter), but in none in the acebutolol group (p <0.001). This study reveals the efficacy of acebutolol in prevention of supraventricular tachyarrhythmias after CABG. Supraventricular ... may have deleterious hemodynamic consequences. To determine if acebutolol, a cardioselective β-blocking drug, prevents such tachyarrhythmias ...
Tópico(s): Cardiac Arrhythmias and Treatments
1986 - Elsevier BV | The American Journal of Cardiology
M. Bigorre, Aurélie Khau Van Kien, Huguette Valette,
... not been studied. We report the effect of acebutolol (β-blocking agent), 10 mg/kg/day, in ... day) and developed high blood pressure that necessitated acebutolol given at 10 mg/kg/day. The effect ... was 5 months old. We attempted to stop acebutolol at 4 months but noticed that the hemangioma swelled each time we discontinued the drug. Acebutolol was maintained until the age of 1 year, ... response after 15 days of treatment, we began acebutolol at 10 mg/kg/day. The corticosteroid dosage was decreased slowly over 3 months and acebutolol was stopped at 1 year of age. The ...
Tópico(s): Vascular Tumors and Angiosarcomas
2009 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Marie Pospı́šilová, Andrea Kavalírová, Miroslav Polášek,
Acebutolol [N-{3-acetyl-4-[(2-hydroxy-3-(isopropylamino)propoxy]phenyl} butanamide] is a cardioselective beta-blocker ... electrolytes for the newly developed ITP separation of acebutolol consisted of 10mM potassium acetate +10mM acetic acid ( ... min. Under these conditions the effective mobility of acebutolol was determined as 20.7 x 10(-9) ... 0.14-1.4 mg ml(-1) of acebutolol base (r = 0.9995); relative standard deviation (RSD) ... 42 and 0.98 mg ml(-1) of acebutolol in a pure standard solution. The method, with ... ml(-1), was applied to the assay of acebutolol in Sectral tablets, Acecor tablets, Apo-acebutol tablets ( ...
Tópico(s): Analytical Methods in Pharmaceuticals
2005 - Elsevier BV | Journal of Chromatography A
Jari J. Lilja, Kari Raaska, Pertti J. Neuvonen,
... aimed to investigate effects of grapefruit juice on acebutolol pharmacokinetics. Methods In a randomized cross‐over study, ... On day 3, each subject ingested 400 mg acebutolol with grapefruit juice or water. The concentrations of acebutolol and its metabolite diacetolol were measured in plasma ... decreased the peak plasma concentration ( C max ) of acebutolol by 19% from 872 ± 207 ng mL −1 ... 05). The half‐life ( t 1/2 ) of acebutolol prolonged from 4.0 to 5.1 h ( ... time to peak concentration and the amount of acebutolol excreted into urine (Ae) were unchanged. The C ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2005 - Wiley | British Journal of Clinical Pharmacology
Kyotaka Muta, Tatsuki Fukami, Miki Nakajima,
Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to diacetolol. Because metabolic activation has been considered to be related to acebutolol-induced toxicity, we sought to identify the enzymes that are responsible for acebutolol metabolism and investigate their involvement in acebutolol-induced toxicity. By using human liver microsomes (HLM) ... 2 (NAT2). When acetolol, a hydrolytic metabolite of acebutolol, was incubated with HLM and an NADPH-generating ...
Tópico(s): Drug Transport and Resistance Mechanisms
2015 - Elsevier BV | Biochemical Pharmacology
Henry Lui, Garrett Lee, Raja W. Dhurandhar, Elizabeth J Hungate, Atul Laddu, Peter Dietrich, Dean T. Mason,
The antiarrhythmic efficacy of oral acebutolol, a new cardioselective β-blocking agent, was assessed in a randomized double-blind, placebo-controlled study. Twenty-five patients with ≥30 ... and 45% and 50% with the use of acebutolol 200 mg and 400 mg, respectively. Eleven patients had ≥70% reduction in VEB with acebutolol and nine of them had ≥90 VEB reduction. ... but significantly higher following the two doses of acebutolol at 71% (p < 0.05) and 86% (p < ... 01) following 200 mg and 400 mg of acebutolol and only 49% after placebo. Complete suppression of ...
Tópico(s): Cardiac pacing and defibrillation studies
1983 - Elsevier BV | American Heart Journal
Acebutolol was compared to placebo, propranolol, and quinidine for the suppression of chronic ventricular arrhythmia in three ... periods. Compared to baseline in all three studies, acebutolol significantly (p < 0.002 to p < 0.001) ... total PVCs and complex PVCs. In all measurements, acebutolol was superior to placebo (p < 0.02 to ... 001) and comparable to propranolol and quinidine. During acebutolol treatment, 39% of the patients had reductions of ≥ ... Similar numbers of patients had ≥ 75% reductions during acebutolol treatment in comparison with propranolol and quinidine. Acebutolol ...
Tópico(s): Cardiac pacing and defibrillation studies
1985 - Elsevier BV | American Heart Journal
Thomas L. Whitsett, David C. Levin, Carl V. Manion,
... 1 and beta 2 adrenoceptor blocking properties of acebutolol and propranolol and measure the plasma levels of acebutolol, its acetylated metabolite and propranolol. Ten patients with ... and hypertension received two separate dose levels of acebutolol and propranolol for five days each. Cardioselective properties ... end of each five-day treatment period. Both acebutolol and propranolol were clinically well tolerated. Following study ... effect. There were no clinically significant differences between acebutolol and propranolol. The acetylated acebutolol metabolite accumulated levels ...
Tópico(s): Analytical Chemistry and Sensors
1982 - Elsevier BV | CHEST Journal
David O. Williams, Ronald Tatelbaum, Albert S. Most,
... efficacy of the new beta adrenergic blocking agent acebutolol, 15 monitored patients with supraventricular arrhythmias received, in double-blind fashion, an intravenous infusion of either acebutolol or saline solution after a control period. Patients ... or conversion to sinus rhythm. After administration of acebutolol, significant (P < 0.05) reductions in heart rate ... 10 to 30 minutes and correlated with maximal acebutolol plasma concentrations. Despite a rapid subsequent decrease in acebutolol plasma concentrations, antiarrhythmic activity persisted for 24 hours. ...
Tópico(s): Poisoning and overdose treatments
1979 - Elsevier BV | The American Journal of Cardiology
Gary L. Wollam, Robert Cody, Robert C. Tarazi, Emmanuel L. Bravo,
The relative cardioselectivity of acebutolol in man was studied by comparing its hemodynamic effects with those of two other β‐blockers—propranolol, a nonselective β‐ ... hypertensive patients before and after intravenous administration of acebutolol 1 mg/kg (9 patients), practolol 50 mg ( ... 10 mg (21 patients). The hemodynamic changes after acebutolol were similar to those obtained with practolol but not as striking as those with propranolol. Acebutolol did not differ significantly from practolol with respect ...
Tópico(s): EEG and Brain-Computer Interfaces
1979 - Wiley | Clinical Pharmacology & Therapeutics
Richard J. Katz, Robert DiBianco, Steven Singh, Rebecca Bortz, Hampton R. Bates, Bertrum Sauerbrunn, Atul Laddu, Ross D. Fletcher,
We assessed the effects of acebutolol, a cardioselective beta blocker, on global and regional left ventricular function in 26 patients with chronic angina pectoris. All patients underwent ... exercise radionuclide angiography while on placebo and oral acebutolol (400 mg three times a day). Resting ejection fraction on placebo was 51 ± 3% and on acebutolol was 54 ± 3% (p < 0.05). No resting ... ejection fraction 28% on placebo and 21% on acebutolol) developed signs of fluid retention. Exercise nuclear studies ... was of the same order on placebo and acebutolol (51 ± 3% and 54 ± 3%, p = NS). In ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1981 - Wiley | Clinical Pharmacology & Therapeutics
Kouichi Kawazu, Akemi Oshita, Tadahiro Nakamura, Mikiro Nakashima, Nobuhiro Ichikawa, Hitoshi Sasaki,
... of this study is to characterize transport of acebutolol through the corneal epithelium. Cultured normal rabbit corneal ... mixture F-12 with various supplements. Measurements of acebutolol permeability through RCEC layer were carried out to ... hydrophilic drugs (P(cell)). The transcellular permeability of acebutolol from apical side to basal side (A-to-B) showed concentration-dependency. The acebutolol flux in the A-to-B direction was ... and cyclosporin A enhanced the transcellular permeability of acebutolol in the A-to-B direction. Acebutolol permeability ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2006 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Bramah N. Singh, William R. Thoden, Janice Wahl,
Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing ... of mild to moderate essential hypertension, once-daily acebutolol as monotherapy provides effective control in a large ... in blood pressure when used concomitantly with diuretics. Acebutolol is as effective as other beta-blocking agents, ... and patient withdrawals due to adverse effects. Oral acebutolol is also effective in suppressing premature ventricular contractions, ...
Tópico(s): Cardiac pacing and defibrillation studies
1986 - Wiley | Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Hanieh Karimiyan, Mohammad Reza Hadjmohammadi, Karthik Laxman, Mohammad Mahdi Moein, Joydeep Dutta, Mohamed Abdel‐Rehim,
... subsequently applied for the extraction of β-blockers, acebutolol, and metoprolol in human oral fluid samples, which ... 5.0 to 2000 nmol L-1 for acebutolol and 25.0 to 2000 nmol L-1 ... 0.998 and 0.996 (n = 3) for acebutolol and metoprolol, respectively. The recovery of analytes during extraction was 80.0% for acebutolol and 62.0% for metoprolol, respectively. The limit ... 1.25, 8.00 nmol L-1 for acebutolol and metoprolol and the lower limit of quantifications (LLOQ) were 5.00 nmol L-1 for acebutolol and 25.0 nmol L-1 for metoprolol. ...
Tópico(s): Analytical Methods in Pharmaceuticals
2019 - Multidisciplinary Digital Publishing Institute | Molecules
Joanna Tyczka, Jacek Nadolski, Magdalena Roszak, Wojciech Dyszkiewicz, P. Ciszewski,
... The study was prospective and randomized controlled trial. Acebutolol and diltiazem versus placebo were compared, among 117 ... one of the three groups: those who received acebutolol (Group 1) or diltiazem (Group 2) and compared ... the intensive care unit. Results In patients receiving acebutolol AF occurred in 5% compared with 23% of ... patients receiving placebo (difference not statistically significant). Conclusions Acebutolol and diltiazem appear to have been non-effective ... effects were mild. In comparison to diltiazem, however, acebutolol had a beneficial effect on the circulatory system. ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2012 - Georg Thieme Verlag | The Thoracic and Cardiovascular Surgeon
Jialiang Guo, Jincai Wang, Hang Lin, Ying Feng, Huanqi Shen, Ruoshi Huang, Lian Liu, Zhixiong Zhao,
... molecular modeling was undertaken. A chiral β-blocker; acebutolol, was enantioseparated in aqueous capillary electrophoresis and non- ... β-cyclodextrin derivatives. The enantiomer affinity pattern of acebutolol was found to be opposite when an aqueous ... methyl-6-sulfo)-β-cyclodextrin. Molecular docking of acebutolol into two β-cyclodextrin derivatives indicated two distinct ... molecular dynamics and energy minimization, both enantiomers of acebutolol were preferred to the 'up' conformation with heptakis( ... sulfo)-β-cyclodextrin had higher affinity to S-acebutolol than R-acebutolol in non-aqueous capillary electrophoresis ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2019 - Wiley | Journal of Separation Science
Kheng Soo Tay, Norfazrina Madehi,
... In this study, the ozonation by-products of acebutolol, one of the common β-blockers, were identified. The mechanisms for the transformation of acebutolol during ozonation were elaborated. In this study, ozonation ... and hydroxyl radical (OH) in the transformation of acebutolol. Structure elucidation of the ozonation by-products was ... elsewhere. Based on the detected ozonation by-products, acebutolol can be degraded by both O3 and OH. ... becomes a reactive species, the transformation of the acebutolol proceeded via the reaction between the O3 and ...
Tópico(s): Electrochemical Analysis and Applications
2014 - Elsevier BV | Separation and Purification Technology
Ivo Radevski, Sdravka P Valtchanova, Geoffrey Candy, E. Tshele, Pinchas Sareli,
... present study, we assessed the antihypertensive efficacy of acebutolol 200 mg versus carvedilol 25 mg once daily, ... at 3-month intervals as follows: step 2, acebutolol 200 mg or carvedilol 25 mg plus hydrochlorothiazide 12.5 mg once daily; step 3, acebutolol 400 mg or carvedilol 50 mg plus hydrochlorothiazide ... both β blockers at 3 months. In the acebutolol group, 24-hour BP decreased from 142 ± 15/ ... 12 months were 59% and 82% in the acebutolol and 78% and 78% in the carvedilol groups, respectively. In conclusion, acebutolol or carvedilol in combination with hydrochlorothiazide, rather than ...
Tópico(s): Hormonal Regulation and Hypertension
1999 - Elsevier BV | The American Journal of Cardiology
... clinical use involving almost 3 million patient-years acebutolol has become established as a remarkably safe and ... of a once-daily regimen, particularly for hypertension. Acebutolol has low lipid solubility and low protein binding; ... displacement interactions with other drugs are unlikely. Because acebutolol and its metabolite normally have both renal and ... is available should either be compromised through disease. Acebutolol is cardioselective, and clinical use has borne out ... incidence of tiredness and cold extremities observed with acebutolol compared with other beta blockers. The unique pharmacologic ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1978 - Elsevier BV | Journal of Chromatography A
R A Winkle, P J Meffin, WB Ricks, Harrison Dc,
1 We have measured the plasma concentration of acebutolol and a major metabolite in patients on chronic ... was present in concentrations greater than those of acebutolol at all times during the dosing interval in ... plasma concentrations of the acetyl metabolite to unchanged acebutolol was 2.7 +/- 1.0. 4 Previous studies ... measure plasma concentrations of the acetyl metabolite and acebutolol as a single species cannot be used to ... effect. 5 Future studies determining plasma concentration of acebutolol should take this metabolite into account. 6 Further ...
Tópico(s): Statistical Methods in Clinical Trials
1977 - Wiley | British Journal of Clinical Pharmacology
The effects of acebutolol, practolol and propranolol (0.5‐3 m m ) on calcium uptake, calcium binding and ATPase activities of the rabbit ... inhibited microsomal and mitochondrial calcium uptake whereas both acebutolol and practolol showed slight depressant effects. The ATPase ... of microsomal and mitochondrial fractions were decreased by acebutolol, practolol and propranolol; however, the latter agent was ... than the other two. The inhibitory effects of acebutolol, practolol and propranolol on mitochondria and microsomes were ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1976 - Wiley | British Journal of Pharmacology
... after the administration of single oral doses of acebutolol, practolol or propranolol. 2 Plasma levels of these drugs were determined either colorimetrically (acebutolol and practolol) or fluorimetrically (propranolol). The colorimetric assay of acebutolol in plasma is fully described but the other ... beta-adrenoceptor blockade and the plasma level for acebutolol and practolol were well correlated, whereas in the ... study with the respective single oral doses of acebutolol (300 mg), practolol (400 mg) or propranolol (40 ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1975 - Wiley | British Journal of Clinical Pharmacology