By John Quier, Thomas Fraser, John Hume, George Monro, Ambrose Dawson, and Dr. Dodswell; edited by Donald Monro. Book.
0000 - Gale Group | Sabin
Yan-Jun Li, Cai‐Cai Liang, Ling Jin, Juan Chen,
Acetylcholinesterase (AChE) is an important therapeutic target for the treatment of Alzheimer's disease (AD), and the development of natural AChE inhibitors as candidates has played a significant role ... geraniin and corilagin, from Terminalia chebula fruits on AChE were investigated systematically by a combination of inhibition ... and geraniin exhibited strong reversible inhibitory effects on AChE in an uncompetitive manner with the IC50 values ... and 0.51 mM, respectively, while corilagin inhibited AChE activity in a mixed type with the IC50 ...
Tópico(s): Free Radicals and Antioxidants
2023 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Directory of Open Access Journals (DOAJ)
Dr. Paul Wolf, G. Lingen, G. Lingen, David M. Reese, G. Lingen, Jacob Jeanes, Dr. Paul Wolf, G. Lingen, J. G. Millingen, C. Hering, P. Curie, Dr. Paul Wolf, G. Lingen, Dr. V. Bœnninghausen, C. Hering, Dr. H. Scholl, C. Neidhard, J. G. Rosenstein, David H. Scott, Dr. G. Lingen, Dr. P. Bernstein, C. Neidhard, Dr. G. Lingen, C. Nd,
... the Varieties of but One Species of Tooth-Ache, for Which, from Amongst 35 Remedies, We Had ... Given Case, since Many Other Varieties of Tooth-Ache Bring a Still Greater Number of Remedies into ...
1838 - Gale Group | NCCO-STM 1of2
Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang,
The search for acetylcholinesterase (AChE) inhibitors produced by natural sources is of great significance for the prevention and therapy of Alzheimer's disease and has ... plant origin, displayed a mixed inhibition mode on AChE (IC50 = 8.88 ± 0.14 μM). Fluorescence spectra analysis revealed that fisetin statically quenched AChE fluorescence, and the ground state complex was formed ... interactions. Circular dichroism assays showed that fisetin induced AChE structure loosened with a decrease in α-helix ... site (CAS) and increased the stability of the AChE. Interestingly, the combination of fisetin and galantamine enhanced ...
Tópico(s): Phytochemistry and Bioactivity Studies
2023 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Directory of Open Access Journals (DOAJ)
W. Banks, James English, Lincolnshire Thrasher, Martin Cooper, Edward Bradbury, W. Fox, J. Lingard, John Lakin, Lot Drewery, William Gibson Ward, John Teesdale, Henry Portas, Chas. Skelton, William Gibson Ward,
... Nine Hours' Movement, Persons Who Suffer from Tooth-Ache, Tic-Doloreux, Ear-Ache, or Any Other Pain in the Head or ...
1874 - Gale Group | NCCO BritishPolitics
Jong Min An, Kyung Oh Jung, Myung Sook Oh, Dokyoung Kim,
The correlation between diseases and acetylcholinesterase (AChE) has been highlighted in the medical field. In this regard, the AChE-responsive fluorescent probes can enhance the prevention of unexpected human diseases. Herein, we discuss the recent advances in AChE-responsive fluorescent probes capable of detecting the AChE expression and monitoring the AChE activity in real time. The fluorescent probes for AChE can be categorized into three parts based on the AChE sensing rationale. Photophysical properties of the AChE-responsive ...
Tópico(s): Computational Drug Discovery Methods
2023 - Elsevier BV | Dyes and Pigments
Sir G. Lefevre, J. O. M'William, Dr. J. B. Williams, G. Burrows, Alex. Fleming, S. Gower, Dr. C. J. B. Williams, A. Ross, Mr. James W. Ilott, C. J. B. Williams, C. J. B. Williams, O'B. Bellingham, David MacLagan, E. L. Ormerod, James Turnbull, Dr. Julius Vögel, Mr. W. S. Kirkes, M. Nathalis Guillot, A. Makellar, J. H. Toswell, E. B. Sheriffs, George Burrows, Robert Dick, J. Aldridge, J. F. Duncan, J. B. Wilmott, R. J. Graves, Golding Bird, R. H. Allnatt, Golding Bird, E. J. Shearman, H. Kennedy, C. J. B. Williams, C. J. B. Williams, Dr. Julius Vögel, Mr. W. S. Kirkes, G. Badley, J. Hicks, Mr. Thomas Taylor, E. Bishop, H. Letheby, Robert Barnes, J. M. Neligan, John Hogg, John Higginbottom, J. Moore Neligan, J. S. Wilkinson, Golding Bird, M. Ballard, Wm. Fergusson, R. O'Shaughnessy, William Fergusson, Joseph Pancoast, R. Adams, Bransby B. Cooper, Bransby B. Cooper, D. Gilbert, Mr. G. N. Epps, M. Gendrin, J. Luke, Norman Chevers, George W. Campbell, William Craig, J. M. O'Ferrall, Bransby B. Cooper, T. P. Teal, J. C. Christopher, R. S. Davis, John Hamilton, Edward Cock, W. Lawrence, W. Chapman, James Duncan, W. Lawrence, C. W. Stearns, Bransby B. Cooper, J. M. Arnott, S. J. Jeaffreson, Dr. A. Brigham, J. J. Scallan, James Syme, C. Aston Key, Bransby B. Cooper, James Syme, James Duncan, W. Colles, J. P. M'Donald, Benjamin Phillips, M. Leroy D'Etiolles, Isaac Harrinson, F. Le Gros Clark, D. O. Edwards, W. Lawrence, W. R. Wilde, P. W. MacLagan, John Topham, James Jago, M. Brefeld, W. R. Beaumont, W. R. Wilde, R. Graves, R. W. Tamplin, C. Aston Key, J. R. Barton, W. B. Kesteven, G. Southam, H. J. Johnson, John Chippendale, T. G. Geoghegan, A. T. Thomson, Robert Lee, Richard Doherty, John Goodsir, J. H. Bennett, E. W. Murphy, James Syme, Wm. Jackson, J. C. W. Lever, W. Tyler Smith, J. Aldridge, Edward Rigby, Thos. Williamson, Richard Doherty,
... Esq., M. D., &c., Radical Cure of Tooth-Ache, Retroversion of the Uterus.—By Edward Rigby, M. ... Esq., Chelsea, Sulphate of Bebeerine in Intermittent Head-Ache, On the Treatment of Strangulated Hernia after Operation.— ...
1845 - Gale Group | NCCO-STM 1of2
Fang Wang, Mingxue Liu, Xiankang Niu, Xia Lian, Fengli Qu,
Acetylcholinesterase (AChE) is regarded as a biomarker of Alzheimer's disease (AD), and its inhibitors show great potential in AD therapy as AChE can increase the neurotoxicity of the amyloid component ... a simple and highly sensitive strategy to monitor AChE levels and screen highly efficient AChE inhibitors. Herein, we synthesize an ultrathin two-dimensional ( ... construction of a sensitive sensor for the monitoring AChE and screening of its inhibitors. By adding AChE, the acetylthiocholine (ATCh) substrate is hydrolyzed to be ...
Tópico(s): Electrochemical sensors and biosensors
2023 - Elsevier BV | Analytica Chimica Acta
John Harris, Amos Westcott, S. M. Shepherd, W. H. Elliot, J. Robinson, Thos. H. Burgess, H. D. Bulkey, M. Barth, M. Henry Roger, Francis G. Smith, Robert Arthur, Alf. A. L. M. Velpeau, Charles D. Meigs, William Harris, Amos Westcott,
... Shepherd, D. D. S.. Essay: Dissertation on Tooth-Ache. Delivered before the American Society of Dental Surgeons, ... Use of Arsenic as a Remedy for Tooth-Ache, or for Destroying the Lining Membrance of a ...
1845 - Gale Group | NCCO-STM 1of2
Zhonghui Zhang, Zhichao Liu, Peicong Wu, Xinhua Guo, Xiao Luo, Youjun Yang, Jinquan Chen, Yang Tian,
... recognition strategy is created for accurately quantifying acetylcholinesterase (AchE) activity in 24 brain regions of free-moving ... are designed and synthesized for specific recognition of AchE by Raman spectroscopy. After systematically evaluating the recognition ability toward AchE, 2-(4-((4-(dimethylamino)benzoyl)oxy)styryl)-5- ... 1-ium (ET-5) is finally optimized for AchE determination, which shows the highest selectivity, the greatest ... molecules. More interestingly, using the developed probe for AchE with high accuracy and sensitivity, the optimized AchE ...
Tópico(s): Computational Drug Discovery Methods
2023 - Wiley | Advanced Science
... Coughs, Pains in the Head, Heart-Burn, Tooth-Ache, Sore Throats, Corns, Indigestions, Chilblains, Chapped Hands, Lowness ... in Their Good Work, Alum in the Tooth-Ache. Classified ads: Multiple Classified Advertisements. Backmatter: The Journal ...
1832 - Gale Group | NCCO-STM 1of2
Tess Puopolo, Chang Liu, Hang Ma, Navindra P. Seeram,
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. Abnormal hyperactivity of AChE and BChE can lead to cholinergic deficiency, which ... but it remains unclear whether cannabinoids can inhibit AChE and BChE activities. Herein, we aimed to evaluate ... cannabidivarin (CBDV), cannabichromene (CBC), and cannabinol (CBN) on AChE and BChE activities.The inhibitory effects of cannabinoids ...
Tópico(s): Neuroscience and Neuropharmacology Research
2022 - Karger Publishers | Medical Cannabis and Cannabinoids
W. W. H. Thackston, Solyman Brown, Solyman Brown, Solyman Brown, Chapin A. Harris, D. S. Grandin, S. Brown, Solyman Brown,
... York Editor, An Old German Remedy for Tooth-Ache, Asphyxia, or the Appearances of the Teeth of ... Jaws Have Left off Growing, Cure of Tooth Ache,—Destruction of Living Nerve, and Removal of the ...
1841 - Gale Group | NCCO SciTechMed 2 of 2
Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang,
... neurodegenerative disease in elderly individuals, causing dementia. Acetylcholinesterase (AChE) is regarded as one of the most popular ... are frequently cited as a major source of AChE inhibitors. In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6. ... 07 µM, through a monophasic kinetic process. The AChE fluorescence quenching by baicalein was a static process. The binding constant between baicalein and AChE was an order of magnitude of 104 L ...
Tópico(s): Free Radicals and Antioxidants
2022 - Multidisciplinary Digital Publishing Institute | Foods
R, AMICUS JUSTITIE., W. FINCH., R. L., JAMES SMITH.,
... CHECK for 40, dated the 15th day, TOOTH-ACHE and EAR-ACHE.-PERRY's ESSENCE has reecived the sanction and ...
1830 - Gale Group | TDA
Müslüm Gök, Nimrod Madrer, Tamara Zorbaz, Estelle R. Bennett, David Greenberg, David A. Bennett, Hermona Soreq,
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) are involved in modulating cholinergic signaling, but their roles in Alzheimer’s and Parkinson’s diseases (AD ... rs55781031) single-nucleotide polymorphisms (SNPs) of BCHE and ACHE’s 3′-UTR (rs17228616) which disrupt AChE mRNA targeting by miR-608 remained unchanged. qPCR ... dominant splice variant encoding the “synaptic” membrane-bound ACHE-S in human post-mortem superior temporal gyrus ... cholinergic neurons. In contradistinction, the non-dominant “readthrough” AChE-R mRNA variant encoding for soluble AChE was ...
Tópico(s): Computational Drug Discovery Methods
2022 - Frontiers Media | Frontiers in Molecular Neuroscience
Prof. W. Calvert, J. Taft, F. A. Willett, A. Berry, Joseph Richardson, T. F. Davenport, Isaac John Greenwood, Isaac J. Greenwood, J. W. Grant, Alex. Sclanders, Geo. S. Fouke, H. Howard Hayward, A. D. Bartlett, M. W. Hilles, L. G. Whiting,
... s Come Again!", The Hippopotamus with the Tooth Ache, Death from Chlorgform, New Method of Producing Local ...
1861 - Gale Group | NCCO-STM 1of2
Seda Önder, Lawrence M. Schopfer, Wei Jiang, Özden Tacal, Oksana Lockridge,
... markers of the cholinergic and dopaminergic systems. Acetylcholinesterase (AChE) activity has been reported in these cells. Neurotoxic organophosphate compounds that inhibit AChE, also inhibit butyrylcholinesterase (BChE). We confirmed the presence of AChE in the cell lysate by activity assays, Western ... tandem mass spectrometry (LC-MS/MS) of immunopurified AChE. A nondenaturing gel stained for AChE activity identified the catalytically active AChE in SH-SY5Y cells as the unstable monomer. ... BChE protein was similar to that of active AChE protein. The rate of substrate hydrolysis by AChE ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2022 - Elsevier BV | NeuroToxicology
... 224 sheets; 37 cm Cure for the Heart Ache. Performance Program.
0000 - Gale Group | NCCO British Theatre
Jia Liu, Wei Ha, Haixia Zhang, Yan‐Ping Shi,
Acetylcholinesterase (AChE) is generally considered to be a valuable therapeutic target for Alzheimer's disease (AD). To rapidly screen novel AChE inhibitors from Traditional Chinese medicines (TCMs), polydopamine (PDA) ... h-MnO2@PDA) were fabricated in this work. AChE was immobilized onto the surface of h-MnO2@ ... time, and the prepared h-MnO2@PDA immobilized AChE coupled with capillary electrophoresis (CE) was applied to AChE inhibitor screening. The enzyme catalytic activity and kinetic performances of the immobilized AChE were determined by measuring the peak areas of ...
Tópico(s): Alzheimer's disease research and treatments
2022 - Elsevier BV | Journal of Chromatography A
... sheets; 36 cm A Cure for the Heart Ache. Performance Program.
0000 - Gale Group | NCCO British Theatre
Shuaizhang Li, Andrew J. Li, Jinghua Zhao, Michael F. Santillo, Menghang Xia,
Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Inhibition of AChE activity can cause a variety of adverse health effects and toxicity. Identifying AChE inhibitorsAChE inhibitors quickly and efficiently warrants developing AChE inhibition assays in a quantitative, high-throughput screening ( ... platform. In this chapter, protocols for multiple homogenous AChE inhibition assays used in a qHTS system are ...
Tópico(s): Phosphodiesterase function and regulation
2022 - Springer Science+Business Media | Methods in molecular biology
... sheets; 40 cm A Cure for the Heart-Ache. Performance Program.
0000 - Gale Group | NCCO British Theatre
Jia Liu, Rui Ma, Wei Ha, Haixia Zhang, Yan‐Ping Shi,
The inhibition of acetylcholinesterase (AChE) from decomposing acetylcholine (ACh) is regarded as a common therapeutic strategy for Alzheimer's disease (AD). Screening AChE inhibitors is of great significance for AD treatment. In this work, AChE was physically absorbed on the synthesized MnO2-ZIF- ... time, and the fabricated MnO2-ZIF-67 immobilized AChE coupled with capillary electrophoresis (CE) was applied to screening AChE inhibitor. The established MnO2-ZIF-67 immobilized AChE with excellent pH, thermal and organic solvents tolerance ...
Tópico(s): Computational Drug Discovery Methods
2022 - Elsevier BV | Talanta
... 36-56 cm A Cure for the Heart-Ache. Performance Program.
0000 - Gale Group | NCCO British Theatre
Feng Zhang, Sihui Li, Chao Liu, Kun Fang, Yongmei Jiang, Jianyong Zhang, Jie Lan, Lei Zhu, Han-Qing Pang, Wang Gang,
... clinically known as, Alzheimer's disease (AD). Acetylcholinesterase (AChE) can hydrolyze ACh into acetic acid and inactivate choline. Therefore, inhibiting the activity of AChE would help to improve the effectiveness of AD treatment. Currently, the methods for rapid screening of AChE inhibitors are limited. This study reports the application of AChE-immobilized magnetic nanoparticles as a drug screening tool to screen AChE inhibitors for natural products. First, AChE was immobilized on a surface of amino-modified ...
Tópico(s): Computational Drug Discovery Methods
2022 - Elsevier BV | Talanta
... sheets; 40 cm A Cure for the Heart - Ache. Performance Program.
0000 - Gale Group | NCCO British Theatre