Jonathan Northcroft, Frank Davidson, Waldemar Januszczak, John Dugdale, Sue Green, Matthew Wall, Barbara Hall, Hayley Travers, Nigel Botherway, Jeff Dawson, Tony Barrell, Charlotte Packer, David Brown, Helen Davies, Sally Brock, Nicholas Rufford, Alan Hart, Jason Dawe, John Peter, V S, Colin Brennan, Mark Hodgkinson, Patsy Hammond, Professor Gideon Garter, Jonathan Miller, Andrew Longmore, Andrew Denovan, J D, Max Glaskin, Tim Nagle, Frank Whitford, Bob Geldof, Ivo Tennant, David Smith economics editor, Nicolette Jones, Ferdinand Mount, Dennis Pallis, Kathryn Cooper, Sam Gilpin, Susan Bell, William Lewis, Lucy Hughes-Hallett, David Smith, Michael Boon, Peter Sharkey, Charlie McKechnie, David Cracknell Political Editor, Nick Pitt, Steven Poole, Alister McGuire, Neil Wormald, Andrew Sullivan, Richard Simpson, David Cowdry, Dick Preston, Hilary Hemingway, Karen Robinson, June Miller, Matt Holland, Andrew Porter, Jan Battles, Mark Langford, Martin James, Simon Wilde, Panjabi Hit Squad, Tristram Hunt, Steve Hiett, Tom Walker, Anthony Sattin, Robert Winnett, Sir Steve Redgrave, Irwin Stelzer, Tom English, Robin Scott-Elliott, Rosie Millard, Lawrence Dallaglio, Alice Peters, Rachel Dobson, David Dougill, Emma John, Janet Wilson, Philip Kingsley, Thrasy Petropoulos, Vic Chesnutt, Maurizio Pollini, Anne-Marie Conway, Ian Hoyle, Jonathon Carr-Brown, D Taylor, Alasdair Reid, Hugh Canning, Jeremy Clarkson, David Cairns, Victoria Segal, Howard Goddard, Andrew Morton, Helen Kenny, Patricia Nicol, Sarah Dempster, Kevin Jackson, John O'Donnell, Nick Robinson, Peter Millar, Graham Clutton, Alison Coleman, Rev David Banting National Chairman, David Eimer, Max Clifford, Lydia Slater, Alec Nacamuli, Rupert Wright, S W, Shelley von Strunckel, Jeremy Guscott, Paula Robinson, Basil Sufain, Paul Bailey, Andrew Thomas, Roger Sanchez, Dan Channer, Stuart Wavell, Tom Conran, Dominique Coughlin, Liam Foley, Pat Cash, Frances Spalding, Name withheld, Vincent Crump, Zoe Thomas, Paul Wray, Chris Woodhead, Lucinda Kemeny, Jasper Gerard, Paul Driver, C Rankin, Tricia Jarvis, John Humphrys, Nicholas Hellen, Richard Brooks, Ian Hawkey, Ben Wootliff, Christopher Morgan, David Leppard, Alex Clark, Paul Durman, Peter De Savary, Mark Ludlow, Alicia Wyllie, Dave Hannigan, Andy Webb, Kevin Haworth, Mark Edwards, Rachel Bridge, Jane Nottage, Susan Clark, Eben Black Chief Political Correspondent, Jonathan Hoffman, Bella Bathurst, Chrissy lley, Danny O'Brien, Phil Baker, Bill Edmead, Christina Lamb, Robert Rutledge area director, Lois Rogers, Sean Newsom, Raymond Keene, Tom Landell Mills, Gareth Huw Davies, Jane Packer, Douglas Alexander, Mark Stickings, David Cracknell, Bob Davis business development director, Katrina Manson, Julian Parry, Irene Zoech, Rod Liddle, Cosmo Landesman, Jennifer Capriati, R Welland, Stephen Jones, Robbie Burns, Barry Flatman, Richard Evans, Louise Armitstead, Michael Wright, Natalie Graham, Peter Boyle, Duncan Fitter Strategy manager, Colin Parker, Caroline Donald, Beatrice Newbery, Nick Rennison, S D, Love Tony, M J, Fiona Terry, David Walsh, Trevor Lewis, Colin McDowell, Bryan Appleyard, Simon Edwards general manager, Stephen Armstrong, John Elliott, Mark Anstead, Bethan Cole, Michael Sheridan Far East Correspondent, R W Johnson, Roland White, John, Shane Watson, D J Swami, Deborah Hutton, Maurice Chittenden, Alex Fortune, Richard Brooks Arts Editor, Matthew Taylor MP, Richard Rae, Mark Franchetti, Jonathan Breckland, Ray Hutton, Lauren Quaintance, Naomi Wolf, Michael Sheridan, Lynda Hobson, Mike Smith, Niall Ferguson, Clare Francis, James Cracknell, Godfrey Smith, Ron Hines, Barry Collins, Dipesh Gadher, James Foxall, A A Gill, A M C, Brian Glanville, P Rainer, Jeremy Wayne, Robert MacFarlane, Enda Leahy, David Horspool, Philip Webster, Ed Moloney, Simon Long, Nick Fielding, Stephen Pettitt, Chrissy Iley, Will Iredale, Jane Cattani, Justin Sparks, Kenneth Whayman, Tom Walker Diplomatic Correspondent, Naomi Caine, Nigel Powell, David Wickers, Ken Rauer, Sally Kinnes, Roger Dobson, Brian Doogan, Michael Clower, Simon Buckland, Lord Sudeley, Jeremy Lazell, Will Holland, Jane Robson, Graham Norwood, James Knight, Denise Robertson, Joe Lovejoy, Victor Bryant, David Budworth, William Lewis Business editor, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, Phillip Knightley, Alistair Cooke General Secretary, David Smith Economics Editor, Phil Smith business development director, Riot mars Harrison, John Thorne, Anthony Howard, Sarah Baxter, Simon Wardell, Chris Feetenby, Kate Spicer, Matthew Goodman, India Knight, Simon Howard, Craig Rowland managing director, Dominic Rushe, Richard Lewis, Sian Griffiths, Niamh Cusack's,
... says historian Tristram Hunt Egypt 1882: a fine template for running Baghdad today The sophisticated methods of ... Radcliffe and Audley Harrison at the Cadbury Get Active event at the NEC Birmingham, next sunday. Funday ...
2003 - Gale Group | Sunday Times HA GDA
... checking, code optimization with adaption, language embedding and active libraries. However, as template metaprogramming was not an original design goal, the ...
Tópico(s): Software Engineering Research
2010 - Springer Science+Business Media | Lecture notes in computer science
Jonathan Northcroft, Scott Matthews, John Dugdale, Anthony Walker, William Kay, John Angeles, Colin Drury, Barbara Hall, Helena Frith Powell, Nigel Botherway, Sally Gillespie, David Mills, Jim Munro, Sally Brock, Helen Davies, P Downs, Peter Whittle, Rob Hughes, John Peter, J C, Angela Vaughan Parry, Simon Hacker, Amanda Ursell, Jack Ashton, Andrew Longmore, Steve Fryer, Suzanna Koster, Robin Lawton, Christopher Downs, Joanna Duckworth, Sally Emerson, Sylvia Roger, Gareth Walsh, Ranju Dhawan, Frank Whitford, Ivo Tennant, Nicolette Jones, Sybil Kapoor, P M, David Phelan, Jennifer Harper-Deacon, Kyle Knox, David Ross, Jeremy Lazell, Lucy Hughes-Hallett, David Smith, Alan Reeves, P D, Sue Greig, G Forbes, Neil Wormald, Duncan Piper, Clive Davis, Tim Pickles, Karen Robinson, Paul Denovan, Aunt Sally, Gavin Ames, Flora Bagenal, Alan Milburn, Sue Leonard, Philip Constantine, Martin James, Simon Wilde, Edward Grayson founder President, Gemma Scott-Martin, G M, Robert Sandall, Ariel Leve, Andrew Clover, Irwin Stelzer, John Percy, Peter Wilson, Marc Levy, Andy Stewart's, Rosie Millard, David Dougill, Lionel Shriver, Elwyn Thomas, Robert Winnett Whitehall Correspondent, Ghulam Hasnaim, Dr Anne Buckenham Director of Policy Crop Protection Association, John Adamson, Stuart Barnes, Shaakirah Kasuji, H C, David Friend, Cally Law, Paul Forsyth, Rodger Baillie, Isabel Oakeshott, Geraldine Hackett Education Correspondent, Hugh Mcllvanney, Andrew Stone, Kenneth Armitage, Edward Porter, Peter Conradi, John Sergeant, Brain Glanville, David Cairns, Michael Portillo, Andrew McGavin, Stewart Lee, Patricia Nicol, Hilary Clarke, Sarah Dempster, Katharine Houreld, Robert Harris, Mike Pearce, Dave Pollard, Richard Fletcher, Peter Black, Dr Barry Clayton, Martyn Witt, James Delingpole, Eric Rosby, Rex Gooch, Brian Keating, Steven Butcher, Stuart Johnson, Jeff Potter, Mike Laws, Karen Currie, Victoria Hislop, Stuart Wavell, B Bassil, Paul Donovan, Pat Cash, Peter Shearlock, Paul Kimmage, Alan Sheldon, Chris Woodhead, Michael Cole, Zoe Thomas, Steve Boyd, Andrew O'Hagan, Jasper Gerard, Paul Driver, Alan Franklin, Alan Gouk, Peter Kemp, Pip Murphy, Stuart Andrews, J L, David Leppard, J Q, Paul Durman, Chee Phen, Shelley Von Strunckel, Lisa Grainger, Carole Lewis, Mark Edwards, Jane Nottage, Tim Cooper, Colin McDowell, Heston Blumenthal, Hugh Canning, Phil Baker, Helen Ballard, Christina Lamb, David Gravell, Robert Booth, Sean Newsom, Raymond Keene, Roger Wilsher, Rod Liddle, Douglas Alexander, Penelope Lively, David Cracknell, Cosmo Landesman, Ronnie Kasrils Mp, Martin Mitchell, Duncan Castles, Alice Cann, Diana Wright, Glenn Cossey, Nick Ayton, Adrian Bowen, Dominic O'Connell, Simon Rimmington, Stephen Bleach, Eveleen Bingham, Uzi Mahnaimi, Nick Cain, Barry Flatman, Harry Glenister, David Hancock, Louise Armitstead, Sally Homes-MacKay, Chris Brockley, Jean Radcliff, Adrienne Connors, John Paul Flintoff, Caroline Donald, Nick Rennison, Richard Hall, Jessica Brinton, Ian Critchley, Graham Norwood, Helen Brown, Mark MacAskill, Trevor Lewis, Jane Feinmann, Lucy, Kevin Collerman, Andrew Kirby, Robert Baer, Nick MacKinnon, John Elliott, Stephen Armstrong, Anna Mikhailova, Isabel Oakeshott Deputy Political Editor, Wiktor Moszczynski, Bethan Cole, R W Johnson, Roland White, Steward Lee, Steven Swinford, John Gimlette, Maurice Chittenden, N Samuel, Richard Brooks Arts Editor, Dr Simon Barnard, Yuba Bessaoud, Tim Vickery, Victoria Segal, Ray Hutton, Jon Ungoed-Thomas, Stuart Danning, P Caldwell, Annabel Croft, David Gluck, Jonathan Leake, Ria Higgins, Clare Francis, Michael Smith, John Harlow, M R, Chris Haslam, Dipesh Gadher, Mark Kleinman, John Waples, Paul Rowan, A A Gill, David Parsons, Haydock Park, Matthew Campbell, Antony Beevor, Daniel Foggo, Adam Mankelow, John Carey, Lingfield Park, Nirpal Dhaliwal, Stephen Pettitt, Claudia Croft, Jessica Bown, Jonathan Milne, Olivia Cole, M B, Sally Kinnes, Scarlett Johansson, Nigel Powell, Elizabeth Feisst, Stephen Price, Peter Almond, John Aizlewood, Minette Marrin, Cliff Hassall, John Cornwell, James Knight, Mick Jackson, Jenny Bancroft, James Scoltock, Joe Lovejoy, Sarah-Kate, Ali Hussain, Lara Rendell, David Budworth, Jonathan Futrell, Andrew Frankel, Hugh Pearman, Dan Cairns, Jamie Oliver, Fleur Britton, Julie Hudson, David Smith Economics Editor, Robert Randell, Sarah Baxter, Alex Bellos, Tony Gledhill, Graham Sendall, Matthew Goodman, India Knight, Simon Howard, Anthony Roberts, Jason Dawe, Dominic Rushe, Sian Griffiths, Dr Jan Mokrzycki President, Helen Stewart,
... new make-up range, she has a brave template for growing old, says Bethan Cole Tried and ... Amanda Ursell Create your Family Health Tree Hydro Active Chest quest Self-help jewellery What You Should ...
2006 - Gale Group | Sunday Times HA GDA
Zoltán Juhász, Ádám Sipos, Zoltán Porkoláb,
... active libraries are implemented with the help of template metaprogramming (TMP) techniques. In this paper we present an active library designed as an implementation tool for Finite state ...
Tópico(s): Security and Verification in Computing
2008 - Springer Science+Business Media | Lecture notes in computer science
Ábel Sinkovics, Zoltán Porkoláb,
... used in various application areas, such as expression templates, static interface checking, active libraries, etc. Its recognized similarities to pure functional programming languages–like Haskell–make the adoption of advanced functional techniques possible. Such a technique is using monads, programming structures representing computations. Using them actions implementing domain logic can be chained together and decorated with custom code. C++ template metaprogramming could benefit from adopting monads in situations ...
Tópico(s): Software Testing and Debugging Techniques
2013 - Elsevier BV | Science of Computer Programming
... which possesses a significant partial match with the template scaffold (DECAAF). A library of partial motifs, constructed from the active site residues of the template protein, is used to rank a set of ...
Tópico(s): Microbial Natural Products and Biosynthesis
2012 - Public Library of Science | PLoS ONE
Mercedes Crego‐Calama, David N. Reinhoudt, Mattijs G. J. ten Cate,
... allow for the target-driven generation of the active constituents of the library. A template effect for the formation and amplification of the ...
Tópico(s): Chemical Synthesis and Analysis
2005 - Springer Science+Business Media | Topics in current chemistry
James Torrance, Gail J. Bartlett, Craig T. Porter, Janet M. Thornton,
... analyses of convergent evolution and exploring relationships between active site geometry and chemistry. The template library can be queried via a web server at ...
Tópico(s): Enzyme Structure and Function
2005 - Elsevier BV | Journal of Molecular Biology
Aram J. Krauson, Jing He, Andrew W. Wimley, Andrew R. Hoffmann, William C. Wimley,
... where most known membrane-permeabilizing peptides, including the template peptide, are not active. In a screen of 10,000 library members we identified 16 (~0.2%) that are ...
Tópico(s): Biochemical and Structural Characterization
2013 - American Chemical Society | ACS Chemical Biology
Li-Ting Hsu, M. Salvato, K. Nandra, M. Brusa, R. Bender, Johannes Büchner, J. L. Donley, Dale D. Kocevski, Yicheng Guo, Nimish P. Hathi, C. Rangel, S. P. Willner, Murray Brightman, A. Georgakakis, Tamás Budavári, Alexander S. Szalay, M. L. N. Ashby, Guillermo Barro, T. Dahlén, S. M. Faber, Henry C. Ferguson, A. Galametz, A. Grazian, Norman A. Grogin, Kuang-Han Huang, Anton M. Koekemoer, Ray A. Lucas, Elizabeth J. McGrath, Bahram Mobasher, Michael Peth, D. J. Rosario, Jonathan R. Trump,
... ray source counterparts are based on a new library of active galactic nuclei/galaxy hybrid templates appropriate for the faint X-ray population in ...
Tópico(s): Gamma-ray bursts and supernovae
2014 - IOP Publishing | The Astrophysical Journal
Jing He, Aram J. Krauson, William C. Wimley,
... recently performed an iterative screen in which an active consensus sequence from that first‐generation library was used as a template to design a second‐generation library which was then screened against lipid vesicles at very high stringency. Compared to the consensus sequence from the first library, the most active second‐generation peptides are highly potent, equilibrium pore‐ ...
Tópico(s): Neuropeptides and Animal Physiology
2013 - Wiley | Biopolymers
Fabio Fontanot, Pierluigi Monaco,
... spectrophotometric + radiative transfer code grasil and infrared (IR) template library to show that the model correctly reproduces number counts, redshift distributions and active fractions of R−K > 5 sources. We test ...
Tópico(s): Stellar, planetary, and galactic studies
2010 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Ruiqiong Li, Wayne Chou, Julie A. Himmelberger, K. Litwin, Golda G. Harris, David E. Cane, D.W. Christianson,
... as a guide to systematically remold the hydrophobic active site contour in a library of 26 site-specific mutants. Remolded cyclization templates reprogram the reaction cascade not only by reproportioning ...
Tópico(s): Pharmacological Effects of Natural Compounds
2014 - American Chemical Society | Biochemistry
Arnd B. E. Brauer, Marco Nievo, Jeffrey D. McBride, Robin J. Leatherbarrow,
... In particular, this residue was exclusively identified for active chymotrypsin inhibitors selected from a BBI template-assisted combinatorial peptide library. A further kinetic analysis of 26 P2 variant ...
Tópico(s): Chemical Synthesis and Analysis
2003 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
M. Salvato, O. Ilbert, G. Hasinger, A. Rau, F. Civano, G. Zamorani, M. Brusa, M. Elvis, C. Vignali, H. Aussel, A. Comastri, F. Fiore, E. Le Floc’h, V. Mainieri, S. Bardelli, M. Bolzonella, A. Bongiorno, P. Capak, K. I. Caputi, N. Cappelluti, C. M. Carollo, T. Contini, B. Garilli, A. Iovino, S. Fotopoulou, A. Fruscione, R. Gilli, C. Halliday, Jean‐Paul Kneib, Y. Kakazu, Jeyhan S. Kartaltepe, Anton M. Koekemoer, K. Kovač, Y. Ideue, Hiroyuki Ikeda, C. D. Impey, O. Le Fèvre, F. Lamareille, G. Lanzuisi, J. F. Le Borgne, V. Le Brun, S. J. Lilly, C. Maier, S. Manohar, D. Masters, H. J. McCracken, Hugo Messias, M. Mignoli, Bahram Mobasher, Tohru Nagao, R. Pelló, Simonetta Puccetti, E. Pérez‐Montero, A. Renzini, M. Sargent, D. B. Sanders, M. Scodeggio, N. Scoville, P. L. Shopbell, J. Silvermann, Yoshiaki Taniguchi, L. Tasca, L. Tresse, Jonathan R. Trump, E. Zucca,
... normal galaxies (corrected for emission lines) than by active galactic nucleus (AGN) dominated templates, even if these sources have AGN-like X-ray luminosities. Preselecting the library on the bases of the source properties allowed ...
Tópico(s): Astronomy and Astrophysical Research
2011 - IOP Publishing | The Astrophysical Journal
Kaitlin N. Hart, Talia McKay, Weinishet Tedla‐Boyd, Jeffrey Mills, H. J. Bernstein, P. Craig,
... communities. ProMOL compares query protein structures against a library of active site motif templates. ProMOL calculates Levenshtein distances and RMSD values, and ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2015 - Wiley | The FASEB Journal
Constantino Diaz, Christine Labit‐Le Bouteiller, Stéphane Yvon, Aimée Cambon‐Kernëis, Annette Roasio, Marie‐Françoise Jamme, Amélie Aries, Claude Feuillerat, Eric Perret, Frédérique Guette, Pierre Dieu, Brigitte Miloux, Danielle Albène, Nathalie Hasel, Mourad Kaghad, Edgardo A. Ferrán, Jan H. Lupker, Pascual Ferrara,
... of receptors, through the screening of a small library with diverse chemical compounds. Then, an active molecular model of the receptor is built by homology to a validated template, and it is progressively refined by rotamers modification for key side-chains, by VS of the already screened library, and by iterative selection of the model generating the best enrichment. The refined active model is finally used for the VS of ...
Tópico(s): Chemical Synthesis and Analysis
2013 - Wiley | Molecular Informatics
Craig Hill, Wen‐Shan Li, James B. Thoden, Hazel M. Holden, Frank M. Raushel,
The bacterial phosphotriesterase has been utilized as a template for the evolution of improved enzymes for the catalytic decomposition of organophosphate nerve agents. A combinatorial library of active site mutants was constructed by randomizing residues His- ...
Tópico(s): Insect and Pesticide Research
2003 - American Chemical Society | Journal of the American Chemical Society
Aaron Hoffer, Megan Donahue, A. K. Hicks, R. S. Barthelemy,
... UV excess associated with star formation in the active BCGs. We use both fits to a template of an evolved stellar population and library of starburst models and mid-IR star formation ...
Tópico(s): Astrophysical Phenomena and Observations
2012 - Institute of Physics | The Astrophysical Journal Supplement Series
Stephen K. Andrews, Simon P. Driver, L. J. M. Davies, Claudia del P. Lagos, A. S. G. Robotham,
... function, we combine the Bruzual & Charlot (2003) stellar libraries, the Charlot & Fall (2000) dust attenuation prescription and template spectra for emission by dust and active galactic nuclei to predict the CSED -- pre- and ...
Tópico(s): Astronomy and Astrophysical Research
2017 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
... characteristics were analyzed based on an 18-item template grouped into four categories: general information, presentation, content and active learning. Findings Only 81 (29.2 percent) of the 279 libraries evaluated offer some type of instructional material to ...
Tópico(s): Web and
2016 - Emerald Publishing Limited | Library Hi Tech
Govindan Raghunathan, Andreas Marx,
... for saturation mutagenesis that interact with the primer/template strands or are evolutionarily conserved. From this library, we identified mutations that little interfere with DNA polymerase activity. Next, these functionally active mutants were combined randomly to construct a second ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2019 - Nature Portfolio | Scientific Reports
John W. Liebeschuetz, Stuart Jones, Phillip J. Morgan, Christopher W. Murray, Andrew D. Rimmer, Jonathan M. E. Roscoe, Bohdan Waszkowycz, Pauline M. Welsh, William A. Wylie, Stephen Young, Harry Martin, Jacqui Mahler, Leo Brady, Kay Wilkinson,
... screening of libraries for fit to a protein active site, has been used to find novel leads against the serine protease factor Xa. A small seed template was built upon using three iterations of library design, virtual screening, synthesis, and biological testing. Highly ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2002 - American Chemical Society | Journal of Medicinal Chemistry
Lu Cui, Yu Wang, Zhihong Liu, Hongzhuan Chen, Hao Wang, Xinxin Zhou, Jun Xu,
... key active components of BD. Using these key active components as templates, we have discovered five new AChE inhibitors through virtual screening of a commercial compound library. The new AChE inhibitors have been confirmed with ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2015 - American Chemical Society | Journal of Chemical Information and Modeling
Zheng Yan, Michaël Kahn, Maher Qabar, Ján Urban, Hwa-Ok Kim, Mark A. T. Blaskovich,
... 1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial library based on a peptidomimetic beta-strand template.
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Sonja Schüssler, Ilka Haase, Markus Perbandt, Boris Illarionov, Alexandra Siemens, Klaus Richter, Adelbert Bacher, Markus Fischer, Tobias Gräwert,
... replacement using human GTP cyclohydrolase I as a template. The protein is a D 5 -symmetric decamer with ten topologically equivalent active sites. Screening a small library of about 9000 compounds afforded several inhibitors with ...
Tópico(s): Biochemical and Molecular Research
2019 - Wiley | Acta Crystallographica Section F Structural Biology Communications
Wilko Duprez, Prabhakar Bachu, Martin J. Stoermer, Stephanie Tay, Róisín M. McMahon, David P. Fairlie, Jennifer L. Martin,
... previously reported structure of a Proteus mirabilis DsbA active site cysteine mutant, in a non-covalent complex with the heptapeptide PWATCDS, was used as an in silico template for virtual screening of a peptidomimetic fragment library. The highest scoring fragment compound and nine derivatives were synthesized and evaluated for DsbA binding and inhibition. These experiments discovered peptidomimetic fragments with inhibitory activity at millimolar concentrations. Although only weakly potent relative to larger covalent peptide inhibitors that interact through the active site cysteine, these fragments offer new opportunities as ...
Tópico(s): Peptidase Inhibition and Analysis
2015 - Public Library of Science | PLoS ONE
Zoltán Beck, Garrett M. Morris, John H. Elder,
... are described as an approach to identifying optimal templates for broad-based inhibitor development. Keywords: HIV-1 Protease Substrate Selectivity, Highly Active Anti-Retroviral Therapy (HAART), Viral Infectivity Factor (VIF), Lentiviruses, HIV-1 PROTEASE, Engineered Proteases, Phage-Display Libraries
Tópico(s): HIV-related health complications and treatments
2002 - Bentham Science Publishers | Current Drug Targets - Infectious Disorders
Ann M. Peterson, Carolina Barillas‐Mury, Michael A. Wells,
... generated using the polymerase chain reaction (PCR) with template isolated from a midgut cDNA library phage stock, a mixture of degenerate primers synthesized to code for the highly conserved region around the active site serine found in trypsins, and the T7 ...
Tópico(s): Plant Physiology and Cultivation Studies
1994 - Elsevier BV | Insect Biochemistry and Molecular Biology
Anaïs F. M. Noisier, Craig S. Harris, Margaret A. Brimble,
An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation ...
Tópico(s): Analytical Chemistry and Chromatography
2013 - Royal Society of Chemistry | Chemical Communications