Achmad Fauzi Kamal, Fahmi Anshori, Evelina Kodrat,
Osteofibrous dysplasia (OFD) and Osteofibrous dysplasia-like Adamantinoma have a similar appearance both in clinical and radiography, but different in its histopathology. Despite this similarity, the treatment and prognosis are different, ... later became enlarged. Diagnosis of osteofibrous dysplasia and adamantinoma was considered. We performed limb-salvage procedure by ... immunostaining confirmed the diagnosis as osteofibrous dysplasia-like adamantinoma. In this case it is a very rare ... radiographic characteristics, histopathology features the distinction between classic adamantinoma and OFD-like adamantinoma based on the predominant ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - Elsevier BV | International Journal of Surgery Case Reports
Naser M. Ali, Stefania Niada, Mark R. Morris, A.T. Brini, David Huen, Sumathi Vaiyapuri, Farida Latif,
Adamantinoma and osteofibrous dysplasia (OFD)-like adamantinoma are rare primary bone tumors that are predominantly confined to the tibia. These 2 entities show similarities in location, histology, and radiologic appearance; however, adamantinoma is malignant and therefore differentiating between these bone ... and RNA sequencing (RNA-Seq) were conducted on adamantinoma and OFD-like adamantinoma tumors. Copy number variation analysis using WES data revealed distinct chromosomal alteration profiles for adamantinoma tumors compared with OFD-like adamantinomas, allowing molecular ...
Tópico(s): Genetic factors in colorectal cancer
2019 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Daniel W. Scholfield, Zain Sadozai, C. Ghali, V. P. Sumathi, Hassan Douis, L. Gaston, R.J. Grimer, Lee Jeys,
... progression between benign osteofibrous dysplasia (OFD), OFD-like adamantinoma and malignant adamantinoma, and to investigate the rates of local recurrence, ... of all patients presenting with OFD, OFD-like adamantinoma and adamantinoma between 1973 and 2012 was undertaken. Complete data ... 42 with OFD; ten with an OFD-like adamantinoma and 21 with an adamantinoma). The mean follow-up was 10.3 years ( ... 11.6 years (0.25 to 33) for adamantinoma.The mean age at diagnosis for OFD was ... like and 34 years (14 to 86) for adamantinoma. A total of 24 of the 42 patients ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2017 - British Editorial Society of Bone & Joint Surgery | The Bone & Joint Journal
Richard M. Taylor, Takeshi Kashima, David Ferguson, Károly Szuhai, Pancras C.W. Hogendoorn, Nicholas A. Athanasou,
Adamantinoma of long bones and osteofibrous dysplasia are rare, osteolytic primary bone tumours of uncertain origin containing ... investigated the nature of the stromal cells in adamantinoma of long bones and osteofibrous dysplasia, and determined ... western blot) and immunohistochemical studies on cases of adamantinoma of long bones and of osteofibrous dysplasia were ... osteoclast markers. Ultrastructural and immunophenotypic studies on cultured adamantinoma and osteofibrous dysplasia stromal cells showed that these ...
Tópico(s): Oral and Maxillofacial Pathology
2011 - Elsevier BV | Modern Pathology
Morgan Camp, Ryan K. Tompkins, Suzanne S. Spanier, Julia A. Bridge, Charles H. Bush,
... 553–566. Google Scholar3 FischerB. Uber ein primares adamantinoma der tibia. Virchows Arch [B]1913;12:422–441. Google Scholar4 KahnLB. Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skeletal Radiol2003;32(5):245–258. Crossref, Medline, ... Scholar5 KeeneyGL, Unni KK, Beabout JW, Pritchard DJ. Adamantinoma of long bones: a clinicopathologic study of 85 ... 737. Crossref, Medline, Google Scholar6 MoonNF, Mori H. Adamantinoma of the appendicular skeleton—updated. Clin Orthop Relat ... Bloem JL, Taminiau A, Hogendoorn P. MRI of adamantinoma of long bones in correlation with histopathology. AJR ...
Tópico(s): Genetic factors in colorectal cancer
2008 - Radiological Society of North America | Radiographics
Briana C. Gleason, Bernadette Liegl‐Atzwanger, Harry P. Kozakewich, Susan A. Connolly, Mark C. Gebhardt, Jonathan A. Fletcher, Antonio R. Pérez‐Atayde,
Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals. Although OFD has typical histopathologic features, areas resembling ... a precursor to or a regressive phase of adamantinoma. The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma. We studied the clinical, imaging, histopathologic, immunohistochemical, ultrastructural, ... with OFD were generally younger than those with adamantinoma. Osteoblastic and osteoclastic activity was more prominent in ...
Tópico(s): Oral and Maxillofacial Pathology
2008 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Mustafa Khan, Ritesh Darji, U. Prabhakar Rao, Richard L. McGough,
... breached. DIFFERENTIAL DIAGNOSIS Osteofibrous dysplasia (Campanacci's disease) Adamantinoma Fibrous dysplasia Ewing's sarcoma/primitive neuroectodermal tumor ... pankeratin. No increased mitotic activity was noted. DIAGNOSIS Adamantinoma DISCUSSION AND TREATMENT Adamantinoma is a low-grade malignant bony neoplasm of ... to their bony counterparts. The initial symptoms of adamantinoma are often indolent and nonspecific. Most patients present ... evidence to suggest causality. The embryological origin of adamantinoma continues to be debated. Early reports suggested that ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2006 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Masahito Hatori, Mika Watanabe, Masami Hosaka, Hironobu Sasano, Masaharu Narita, S. Kokubun,
Adamantinoma is known as a low-grade malignant biphasic tumor. Classic adamantinoma is in general characterized by admixture of both ... of bone during infancy and childhood. OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in ... to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma. We report an unusual case of adamantinoma arising in the tibia, with an extensive review ... findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma. At the age of 12 ...
Tópico(s): Soft tissue tumor case studies
2006 - Tohoku University | The Tohoku Journal of Experimental Medicine
Masahiko Kanamori, Cristina R. Antonescu, Melody Scott, Robert S. Bridge, James R. Neff, Suzanne S. Spanier, Mark T. Scarborough, Gerardo Vergara, Howard G. Rosenthal, Julia A. Bridge,
Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of ... 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary ... may be useful in establishing the diagnosis of adamantinoma. Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of ...
Tópico(s): Genetic factors in colorectal cancer
2001 - Elsevier BV | Journal of Molecular Diagnostics
Genevieve Kuruvilla, German C. Steiner,
... report describes five cases of osteofibrous dysplasia—like adamantinoma of the tibia in young patients ranging from ... recurrences. Follow-up showed no progression to classic adamantinoma. Osteofibrous dysplasia—like adamantinoma is a special histological type of adamantinoma that affects children and adolescents. It differs from classic adamantinoma in that it lacks conspicuous nests and masses ... good. Recent publications suggest that osteofibrous dysplasia—like adamantinoma is a precursor of classic adamantinoma. In a ...
Tópico(s): Histiocytic Disorders and Treatments
1998 - Elsevier BV | Human Pathology
Bogdan Czerniak, R. R. Rojas-Corona, Howard D. Dorfman,
... histologic features of 25 cases of long bone adamantinoma is presented. To answer some questions concerning the ... histologic, and immunohistochemical patterns, a new type of adamantinoma termed "differentiated adamantinoma" could be distinguished from the classic long bone adamantinomas. The diagnostic features characteristic of the differentiated adamantinoma include: patient age (first two decades), intracortical location ... of an osteofibrous dysplasia-like pattern in differentiated adamantinoma is the result of a secondary reparative process ...
Tópico(s): Adrenal and Paraganglionic Tumors
1989 - Wiley | Cancer
Michael G. Rock, John W. Beabout, K. Krishnan Unni, Franklin H. Sim,
... 1796-1805, Google Scholar4. Huvos AG. Marcove RC: Adamantinoma of long bones: A clinicopathological study of fourteen ... Scholar5. Yoneyama T, Winter WG. Milsow L: Tibia! adamantinoma: Its histogenesis from ultrastructural studies. Cancer 1977; 40:1 1381142. Google Scholar6. Moon NF: Adamantinoma of the appendicular skeleton: A statistical review of ... ScholarSuggested Reading Google ScholarAnderson CE, Saunders JBdeCM: Primary adamantinoma of the ulna. Surg Gynecol Obstet 1942; 75: ... ScholarBaker PL, Dockerty M B, Coventry M B: Adamantinoma (so-called) of the long bones: Review of ...
Tópico(s): Cardiac tumors and thrombi
1983 - Slack Incorporated (United States) | Orthopedics
Robert J. Gorlin, Anand P. Chaudhry, J. J. Pindborg,
... Thoma, K. H. 137 13 Brandon, S. A.: Adamantinoma of left maxillary area; report of case. J. ... 169–170, 1952. 20 Campbell, J. A. H.: Adamantinoma containing tissue resembling granular-cell myoblastoma. J. Path. & ... F. W.: Malignant angioblastoma of bone; reappraisal of adamantinoma of long bone. Cancer 10: 540–559, 1957. ... 278–302, 1894. 24 Ch'in, K. Y.: Adamantinoma in Chinese; pathological study of 41 cases. Chinese ... 1955. 40 Frantz, V. K., and Stix, L.: Adamantinoma; case of 51 years' duration. Arch. Surg. 25: ...
Tópico(s): Bone Tumor Diagnosis and Treatments
1961 - Wiley | Cancer
Dimitrios Varvarousis, Georgios P. Skandalakis, Alexandra Barbouti, Γεώργιος Παπαθανάκος, Panagiotis Filis, Kostas Tepelenis, Aikaterini Kitsouli, Panagiotis Kanavaros, Panagiotis Kitsoulis,
Adamantinoma is a biphasic tumor, with a low potential for malignancy, characterized by clusters of epithelial cells ... histopathological and ultrastructural findings; and treatment options of adamantinoma. In X-ray, it is usually seen as ... the most appropriate examination for differential diagnosis between adamantinoma and other skeletal tumors. Histologically, adamantinoma is identified as classic adamantinoma or osteofibrous-like adamantinoma. Classic adamantinoma is classified into four patterns of ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2021 - Stanford University Highwire Press | In Vivo
Produção Nacional
Revisado por pares
Leandro Infantini Dini, Rodrigo Mendonça, Carlos A. Adamy, Glauco A. Saraiva,
... patient with a cervicothoracic spinal and a mandibular adamantinoma. Adamantinoma is a rare malignant neoplasm of bone and, ... there have been only five cases of spinal adamantinoma reported. The pathogenesis of the adamantinoma, as well as the management of this extremely ... because of tumor recidivity and spine instability. CONCLUSION: Adamantinoma, an extremely rare lesion, is a locally aggressive ... is an extremely rare occurrence in the spine, adamantinoma should be considered on the diagnosis of tumors ...
Tópico(s): Adrenal and Paraganglionic Tumors
2006 - Lippincott Williams & Wilkins | Neurosurgery
Masahiiko Maki, Nicholas A. Athanasou,
... investigate the relationship between osteofibrous dysplasia (OFD) and adamantinoma, we analyzed the expression of several proto-oncogene ... seen in OFD and around cell nests in adamantinoma. E-, P-, and N-cadherin expression was found in all cases of classical adamantinoma, but not in differentiated adamantinoma or OFD. Osteonectin was detected in both the ... number of oncoproteins and bone matrix proteins in adamantinoma and OFD, some of which are associated with ... hypothesis that OFD represents a precursor lesion of adamantinoma. Differential expression of a number of bone matrix ...
Tópico(s): Sarcoma Diagnosis and Treatment
2004 - Elsevier BV | Human Pathology
Hans Marten Hazelbag, A. H. M. Taminiau, Gert Jan Fleuren, Pancras C.W. Hogendoorn,
... of thirty-two patients who had had an adamantinoma of the long bones were examined to investigate ... histological patterns of differentiation that are characteristic of adamantinoma were observed, including the basaloid, spindle-cell, tubular, ... who had had a presumed osteofibrous dysplasia-like adamantinoma, which contained few isolated keratin-positive epithelial cells ... the time of presentation, had a full-blown adamantinoma at the time of the local recurrence. Although ... to the regressive nature of osteofibrous dysplasia-like adamantinoma. On the basis of our findings and the ...
Tópico(s): Oral and Maxillofacial Pathology
1994 - Wolters Kluwer | Journal of Bone and Joint Surgery
Yoshinao Kikuchi, Takashi Kishimoto, Satoshi Ota, Michiyo Kambe, Yoko Yonemori, Hideaki Chazono, Kazuki Yamasaki, Hidemasa Ochiai, Kenzo Hiroshima, Mio Tanaka, Yukichi Tanaka, Hiroshi Horie, Yukio Nakatani,
Adamantinoma-like Ewing family tumor (EFT) is a rare subset of EFTs showing mixed features of Ewing sarcoma and adamantinoma of the long bones. All currently reported cases of the adamantinoma-like type have been associated with bone. Recently, ... case has characteristics of both a subset of adamantinoma-like EFT and EFT with complex epithelial differentiation. ... differentiation is in a common spectrum with the adamantinoma-like type and that adamantinoma-like EFTs can arise in soft tissue, leading ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2013 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Deepali Jain, Vijay Kumar Jain, Rakesh Kumar Vasishta, Prabhat Ranjan, Yashwant Kumar,
Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion ... a matter of debate. The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and ... nests when the radiological features are suggestive of adamantinoma. There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make ...
Tópico(s): Cardiac tumors and thrombi
2008 - BioMed Central | Diagnostic Pathology
Henk-Jan van der Woude, Hans-Marten Hazelbag, Johan L. Bloem, Antonïe H.M. Taminiau, Pancras C.W. Hogendoorn,
... study were to assess specific MRI features of adamantinoma, including classic adamantinoma and its osteofibrous dysplasia-like variant, and to assess the role of adamantinoma in surgical planning.MR images of 22 patients with histologically proven adamantinoma, subtyped according to defined criteria, were analyzed, with ... relationship between MRI features and histologic subtype of adamantinoma was found.Some uniform MRI characteristics, along with ... of radiography, may contribute to the diagnosis of adamantinoma; however, these are not related to the histologic ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2004 - American Roentgen Ray Society | American Journal of Roentgenology
Abid Qureshi, SUSAN SHOTT, BRUCE A. MALLIN, Steven Gitelis,
Background: Adamantinoma of long bones is a rare tumor. Published reviews of the orthopaedic management of adamantinoma have involved limited follow-up of small numbers ... this study was to evaluate the characteristics of adamantinoma of long bones as well as the oncological ... of limb salvage operations for the treatment of adamantinoma. Data on seventy biopsy-proven cases of adamantinoma treated between 1982 and 1992 at twenty-three ... margins (p = 0.14). Conclusions: Current treatment of adamantinoma, including en bloc tumor resection with wide operative ...
Tópico(s): Oral and Maxillofacial Pathology
2000 - Wolters Kluwer | Journal of Bone and Joint Surgery
Hans Marten Hazelbag, Lambert J. C. M. Van den Broek, Gert Jan Fleuren, Antonïe H.M. Taminiau, Pancras C.W. Hogendoorn,
Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. ... generally present in the (osteo-)fibrous tissue of adamantinoma but lacked in the epithelial aggregates. There was ... keratin-positive cells. These findings suggest that in adamantinoma individual epithelial cells transform from the osteofibrous tissue ... of epithelium, as can be recognized in classic adamantinoma. This is in analogy to the development of ... of biphasic synovial sarcoma. The fibrous part of adamantinoma is, however, believed to be of benign nature. ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
1997 - Elsevier BV | Human Pathology
Yoshiaki Tsukada, Samuel de la Pava, John W. Pickren,
... 1111–1128, 1953. 2 Campbell, J. A. H.: Adamantinoma containing tissue resembling granular-cell myoblastoma. J. Path. ... 1962. 4 Frantz, V. K., and Stix, L.: Adamantinoma—A case of 51 years' duration. Arch Surg. ... Observations on the origin and nature of the adamantinoma with special reference to certain muco-epidermoid variations. ... 1959. 9 Mallik, K. C. B.: An atypical adamantinoma—An adamantinoma with cells resembling granular-cell myoblastoma. Arch. Path. ... 11 McCallum, H. M., and Cappell, D. F.: Adamantinoma with granular cells. J. Path. Bact. 74: 365– ...
Tópico(s): Soft tissue tumor case studies
1965 - Wiley | Cancer
Produção Nacional
Juan Pablo Zumárraga, Ricardo Cartolano, Marcelo Tomio Kohara, André Mathias Baptista, Felipe Gonçalves dos Santos, Olavo Pires de Camargo,
ABSTRACT Objective: Adamantinoma accounts for less than 1% of the primary bone neoplasms. The tibia is the most affected bone and ... obtain epidemiological and clinical information on patients with adamantinoma of the tibia treated surgically between 1989 and ... Methods: Retrospective series of seven patients diagnosed with adamantinoma of the tibia that underwent surgery at the ... with histological reports were evaluated. Seven cases of adamantinoma of the tibia were included. The mean age ... four cases (57.1%). The biopsy revealed bone adamantinoma in four (57.1%) patients, while the diagnosis ...
Tópico(s): Cardiac tumors and thrombi
2018 - Brazilian Society of Orthopedics and Traumatology | Acta Ortopédica Brasileira
Gary M. Sherman, Timothy A. Damron, Yi Yang,
An adamantinoma is a rare, low-grade malignant, osteolytic bone tumor occurring predominately in the diaphysis of the tibia. ... has been suggested as a precursor lesion to adamantinoma. Evidence for the relationship between these two tumors ... ulna is an unusual site of involvement by adamantinoma and osteofibrous dysplasia. Simultaneous involvement of the ulna by adamantinoma and ossifying fibroma has not been previously reported. A case is presented of an adamantinoma of the distal ulna with unique pathologic features ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2003 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Donald E. Sweet, Tuyethoa N. Vinh, Kenneth O. Devaney,
... attempt at defining the relationship of COFD to adamantinoma. The patients ranged in age from newborn to ... lesions (93%). However, hyperchromatic epithelial islands characteristic of adamantinoma were not found in any of the 30 ... morphologic similarities of many areas of COFD and adamantinoma (particularly the shared presence of cytokeratin-positive cells) ... a more than coincidental association between COFD and adamantinoma. However, to date none of the 30 cases ... COFD evaluated in this study has developed an adamantinoma.
Tópico(s): Medical Imaging and Pathology Studies
1992 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Yoshimichi Ueda, Albert Roessner, A. Bosse, G. Edel, W. Böeker, P. Wuisman,
... view of the still disputed relationship between adult adamantinoma and osteofibrous dysplasia in children, a unique case of adamantinoma, indicating a direct relationship between the two lesions, ... 3% for osteofibrous dysplasia, and of 25% for adamantinoma. A review of the literature, yielding reports with ... separate clinicopathologic entity to be called juvenile intracortical adamantinoma with predominant osteofibrous dysplasia-like features, and which might be a regressing form of adamantinoma specific in childhood.
Tópico(s): Bone health and treatments
1991 - Elsevier BV | Pathology - Research and Practice
Donald M. Cohen, David C. Dahlin, David G. Pugh,
... 515-521 ArticleFree Access Fibrous dysplasia associated with adamantinoma of the long bones Donald M. Cohen M. ... Copy URL References 1. Baker, P. L.: Epithelioma (Adamantinoma Type) Affecting Long Bones. M.S. Thesis, University ... L., Dockerty, M. B., and Coventry, M. B.: Adamantinoma (so-called) of long bones; review of literature ... F. W.: Malignant angioblastoma of bone; reappraisal of adamantinoma of long bone. Cancer 10: 540– 559, 1957. ... 5. Dockerty, M. B., and Meyerding, H. W.: Adamantinoma of tibia; report of 2 new cases. J. ...
Tópico(s): Sarcoma Diagnosis and Treatment
1962 - Wiley | Cancer
C.R. Chandrasekar, Riazuddin Mohammed, Awad Abdelmonem Rafalla, R. J. Grimer,
Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours. It is a slow ... metastatic carcinoma, fibrous cortical defect and osteofibrous dysplasia. Adamantinoma commonly occurs in the tibia. It is also ... in the fibula, femur, humerus, radius and ulna. Adamantinoma of the foot is extremely rare. There are ... metatarsal and cuneiform bone involvement. To our knowledge adamantinoma of the calcaneum has not been previously reported ... patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2009 - Elsevier BV | The Foot
Kai Cao, Michiro Susa, Itsuo Watanabe, Kazumasa Nishimoto, Keisuke Horiuchi, Aya Sasaki, Yuichiro Hayashi, Katsura Emoto, Kaori Kameyama, Masaya Nakamura, Morio Matsumoto, Hideo Morioka,
Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that ... and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due ... the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with ... the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2016 - BioMed Central | Journal of Medical Case Reports