Book.
0000 - Gale Group | The Making of Modern World
Bret S.E. Heale, Liam P. Keegan, Leeanne McGurk, Gracjan Michlewski, James Brindle, Chloë M. Stanton, Javier F. Cáceres, Mary A. O’Connell,
Article27 August 2009Open Access Editing independent effects of ADARs on the miRNA/siRNA pathways Bret S E ... InMendeleyWechatReddit Figures & Info Adenosine deaminases acting on RNA (ADARs) are best known for altering the coding sequences ... as in the GluR-B Q/R site. ADARs have also been shown to affect RNA interference ( ... specific adenosines to inosine. Here, we show that ADAR proteins can affect RNA processing independently of their ... editing per se and that even genomically encoded ADARs that are catalytically inactive may have such functions. ...
Tópico(s): CRISPR and Genetic Engineering
2009 - Springer Nature | The EMBO Journal
Kevin Dunn, Henning Mankell, Terry Blaney, Hala Jaber, Humprey Carpenter, John Dugdale, Brian Glaville, Matthew Wall, Nick Alexander, Mark McCrum, Nigel Botherway, Ian Fraser, Rocky Marciane, Tony Wilcock, Rob Kiat, Kitty Kelley, Hari Kunzru, Fred Redwood, Jim Munro, Peter Whittle, Helen Davies, John Peter, Amanda Ursell, Gillian Harding, Andrew Longmore, Lesley White, Adrain Nicole LeSianc, Susan d'Arcy, Gareth Walsh, Richard Thomas, Frank Whitford, Ivo Tennant, Nicolette Jones, Sara MacEfield, Ferdinand Mount, Kathryn Cooper, Gillian Slovo, Susan Bell, Peggy Tolleson, David Smith, Alastair McCall, Tim Richards, Adam Nicolson, Cosmo Landman, Steven Poole, J M Coetzee, Nick Pitt, Neil Wormald, Elena Wynne, Clive Davis, Sal Romaguera, Fiona King, James Glover, Peter Scoritt, Andrew Porter, Nicholas Crane, Derek Scott, Tony Allen-Mills, David Bender, Simon Wilde, Martin James, Anthony Sattin, Robert Winnett, Dan Green, Ian Hawkey European Football Correspondent, Irwin Stelzer, Adrian Furnham, Robert Hewison, Peter Wilson, Rosie Millard, Doughlas Alexander, David Dougill, Nicholas Hellen Social Affairs Editor, John Arlidge, Adam Hodge, Frank Graham, Elizabeth Shaw, Joe Bennett, Colling McDowell's, P D James, Steven Pools, Hugh Canning, Margarette Driscoll, Hugh Mcllvanney, Michael Attenborough, Jeremy Clarkson, Victoria Segal, David Cairns, Peter Conradi, Stewart Lee, Nicola Smith, Raf Shakrow, Jonathon Leake, Anthony Peregrine, Patricia Nicol, Sarah Dempster, Adrian Turpin, Dave Pollard, Richard Fletcher, Leonard Slatkin, Partick Dalty, Jason Leonard, Greg Hartwell, Joan Smith, David Eimer, James Delingpole, Alan Combos, Paul Oakenfold, Lydia Slater, Sussan Clark, Jane Molloy, Minette Martin, Dr Philip Edmondson, Mike Laws, Nichalas Hellen, Paul Ham, Sarah-Kate Templeton, Roger Eglin, Charles Chesshire, Paul Donovan, Vincent Crump, John Owen, Paul Kimmage, Chris Woodhead, Zoe Thomas, Ian Adamson, Lucinda Kemeny, Roberts Woods, Jasper Gerard, Sir Clive Woodward, Paul Driver, Garth Pearce, Bethon Cole, Donna Freydkin, Richard Brooks, Arthur Lee, John Boorman, Ian Hawkey, Shelley Von Strunckel, Alex Clark, David Leppard, Giles, Bert Wright, Paul Durman, Alicia Wyllie, Mark Edwards, Rachel Bridge, John Dougdale, Stephen Amidon, Emina John, Christopher Shann, Jacob Waltz, Jane Bussman, Blower, Cosmo Landeman, Phil Baker, Max Arthur, Sean Newsom, Lisa Helmanis, Nick Falodo, Raymond Keene, Gareth Huw Davies, Rod Liddle, Paul Brauner, Anne Tyler, David Cracknell, Cosmo Landesman, Zoe Brennan, Edith Coron, Damien Lewis, Jim Irvin, Alice Douglas, Emma Smith, Dominic O'Connell, Stephen Jones, Louise Armitstead, Barry Flatman, Michael Wright, John Carlin, I C, Natalie Graham, James Greig, Melvyn Bragg, Erin O'Connor, Sheila Rider, Sir Howard Davies, Fiona Terry, Jessica Brinton, Helen Brown, Justin Forsyth Oxfam Policy Director, Liat Joshi, Trevor Lewis, Jack Grimston, Colin McDowell, Bryan Appleyard, Stephen Armstrong, John Elliott, Peter Taylor, Barbara Hall, Bethan Cole, Victoria O'brien, Richard Woods, Roland White, Ken Prior, Kelly Webb, Angus McGill, Shane Watson, Goran Ivanisevic, Abul Taher, Maurice Chittenden, Alex Fortune, John Walsh, Richard Brooks Arts Editor, Richard Bebb, Sarah Owen, Richard Rae, Mark Franchetti, Ray Hutton, Judith O'Reilly, Martin Ivens, Jonathan Leake, Brendan Simms, Erin Kelly, John Crossland, Dan Box, Julia Liewellyn Smith, Tony Thom, Clare Francis, Amanda Craig, John Harlow, Margaret Walters, Gerry Abrahams, John Waples, A A Gill, Ros Dodd, Stewart Micthcell, Matthew Campbell, Dmitry Beliakov, Richard Forris, John Carey, Tom Robbins, Anne Rowan, Michael Hayes, Nick Fielding, Stephen Pettitt, Edina Ronay, Will Iredale, Jessica Bown, Sally Kinnes, Richard Wood, Shaul Adar, Noelle Walsh, Tom Elliott Professor, Elaine Ladd, Michael Clower, John Aizlewood, John Cornwell, Frank Furedi, Mark Hodson, Graham Norwood, Lois Rogers Medical Editor, Joe Lovejoy, David Budworth, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Dan Cairns, Stephen Leathley, Shrek, Amir Taheri, Christopher Bray, Sally Breck, Stan Lanbowitch, Mike Hammond, Nigal Botherway, David Smith Economics Editor, Rachel De Thame, Tom Deveson, Susannah Price, Matt Roberts, Simon Wardell, Carey Scott, Matthew Goodman, Archie Berans, Simon Howard, Fiona Henderson, Tom Norrington-Davies, Nick Faldo, Dominic Rushe, Robbie Cowling, Colin Charvis, Karen Robinson, Helen Stewart,
... Arab side to win the Isreali Cup. Shaul Adar reports on an inspiring success story Barclays How ...
2004 - Gale Group | Sunday Times HA GDA
Yongfeng Jin, Wenjing Zhang, Qi Li,
Abstract Adenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double‐stranded RNA in animals. Identification of more ADAR targets and genome sequences of diverse eukaryotes present ... opportunity to elucidate the origin and evolution of ADAR‐mediated RNA editing. Comparative analysis of the adenosine deaminase family indicates that the first ADAR might have evolved from adenosine deaminases acting on ... TENR might originate after Urochordata–Vertebrata divergence. More ADAR or ADAR‐like genes emerged in some animals ( ...
Tópico(s): CRISPR and Genetic Engineering
2009 - Wiley | IUBMB Life
Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Mark Ridley, Nicolas Balfour, Michael Barrymore, Matthew Wall, Sue Baker, Joanne Segars, Michael Wright, Nigel Botherway, Tony Booth, Barbara Hall, Aa Gill, David Barber, Darren Gough, Christopher Higgins, A Ross, Otis Ferry, Helen Davies, Nicholas Rufford, Rita Konig, Jason Dawe, John Peter, V S, Pam Barrett, Gideon Garter, Emma Moore, Amanda Ursell, Simon Wise, Jonathan Miller, Jim Munro football editor, Lesley White, Devika Bhat, Christopher Somerville, J D, Amanda Hall, Michael Hare Duke, Ivo Tennant, Nicolette Jones, Ferdinand Mount, David Gower, Kathryn Cooper, Colln Davy, Lucy Hughes-Hallett, David Smith, P D, Tim Richards, Alastair McCall, Peter Sharkey, Rory Godson, David Cracknell Political Editor, Nick Pitt, Ron Ciarke, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Guy Dennis, Ellen MacArthur, Eddie Irvine, Tony Allen-Mills, Simon Wilde, Martin James, Tom Walker, Phil Smith, Anthony Sattin, Robert Winnett, Tom Otley, Irwin Stelzer, Faye Campbell (art historian), Peter Wilson, Rosie Millard, David Dougill, Rachel Dobson, Nicholas Hellen Social Affairs Editor, Jimmy Apostolou, Wilfred Owen, Jon Furmston, Marcus Tanner, David Hewson, Cally Law, Ian Hoyle, Emma Gibson Energy campainger, Jonathon Carr-Brown, Hugh Canning, Geraldine Hackett Education Correspondent, Jeremy Clarkson, Richard Wilson, Edward Porter, Peter Conradi, David Cairns, Louise Taylor, Peter Kemp, Alan Brownjohn, Victoria Segal, J Osborne-Hennessey, Gwen Harlow, Dominic Dromgoole, Travis Elborough, Liz Edwards, Sam Murphy, George Perry, Adam Nathan, Nick Crowe's, Shelley von Strunckel, Jeremy Guscott, Paul Durman City Editor, Jill Douglas, Richard Johnson, D Jackson, Stuart Wavell, Roger Eglin, Paul Donovan, Tom Conran, Monsieur Mangetout, Hugh McIlvanney, Chris Woodhead, Lucinda Kemeny, Bernard Crick, Derek Clements, Paul Driver, John Humphrys, Nicholas Hellen, Richard Brooks, Ian Hawkey, Alex Clark, Christopher Morgan, David Leppard, Amber Cowan, Paul Durman, Mark Ludlow, Hugh Jamieson, Alicia Wyllie, Dj dolly, Mark Edwards, Mick Dennis, Alex clark, Susan Clark, Lucy Wakefield, Chrissy lley, Fluid Canvas, Danny O'Brien, Rubert Steiner, Patrick Rattigan, Karen Gold, Alan Combes, Matt Peskett editor, Hermund Ardalen, Raymond Keene, Gareth Huw Davies, Fiona Morrow, M Shah, David Cracknell, Tim Richardson, Jayesh Ghaghda, Cosmo Landesman, Robbie Hudson, Nick Talbot, Diana Wright, Brigid McConville, Louise Faylor, Stephen Jones, Dominic O'Connell, Dr Raphael Papadopoulos, Barry Flatman, Uzi Mahnaimi, Nick Cain, Rodica Pricop, Commodore R Leaman Director Corporate, Richard Evans, Jonathan Northcraft, Louise Armitstead, Kenneth Clarke, Natalie Graham, Brian O'Brien, Melinda Stevens, Caroline Donald, Nick Rennison, M J, Julie Cohen, Tim Moorey, Keith Wheatley, John Gray, David Walsh, Caroline Gascoigne, John Stern, Trevor Lewis, Jack Grimston, Mike Myles-White, Bryan Appleyard, Lois Rogers Medical Correspondent, Claudia Navone, Stephen Armstrong, John Elliott, Colin McDowell's, Mark Macaskill, Stuart Lockwood, Bethan Cole, Sheherazade Goldsmith, David Price, Richard Woods, Sonia O'Sullivan, Shane Watson, Lesley Gillilan, Maurice Chittenden, Richard Brooks Arts Editor, Judith O'Reilly, Paul Walter, Mark Franchetti, Craig Lord, Richard Rae, Ray Hutton, Ria Higgins, Susan Elkin, Jonathan Leake, Michael Sheridan, Guy Barker, Pamela Piles, John Harlow, Simon Callow, Godfrey Smith, Ian Thomson, Barry Collins, Dipesh Gadher, Gillian Wilmot, James Edsberg, Waldemer Januszczak, Stuart Conway, A A Gill, Matthew Campbell, Brian Glanville, Louise Johncox, John Carey, Enda Leahy, Tom Robbins, David Sumner Smith, Nick Fielding, David Michels chief executive of Hilton, Nico Ladenis, Claudia Croft, Humayun Gauhar, Jason Mellor, Cherry Norton, Michael Vincent, Stephen Pettitt, Jason Corcoran, Sally Kinnes, Naomi Caine, Nigel Powell, Shaul Adar, Chris Grove, David Wickers, Simon Buckland, Minette Marrin, John Aizlewood, Peter Schmeichel, George Davis, Mark Hodson, Andrew Frankel, Dominic Midgley, Joe Lovejoy, Jonathan Futrell, Graham Norwood, Rupert Steiner, F. Courtney, David Budworth, Hugh Pearman, Dan Cairns, Paul Stephen Lubicz, Pete Oliver, Sir David Watson, Jay McInerney, Graham Allen Mp, Tony Allen-mills, Roger Radford, David Smith Economics Editor, Hugh Bradley, Sarah Baxter, Ian Staies, Helen Vandevelde, Matthew Goodman, India Knight, Steve Grant, Richard Whiteside, Kingston Smith, Sandy Gall, Danny Danziger, Barry Newcombe, Dominic Rushe, Richard Lewis, Boris Schapiro, Karen Robinson,
... talisman needs to be watched closely, says Shaul Adar Air-Berlin we fly Europe Barclaycard Premiership Nationwide ...
2002 - Gale Group | Sunday Times HA GDA
Dan-Sung C. Cho, Weidong Yang, Joshua T. Lee, Ramin Shiekhattar, John M. Murray, Kazuko Nishikura,
Adenosine deaminases acting on RNA (ADAR) convert adenosine residues into inosines in double-stranded RNA. Three vertebrate ADAR gene family members, ADAR1,ADAR2, and ADAR3, have been identified. The catalytic domain of all three ADAR gene family members is very similar to that ... the formation of complexes between differentially epitope-tagged ADAR monomers by sequential affinity chromatography and size exclusion ... inactive form. No heterodimer complex formation among different ADAR gene family members was detected. Analysis of HeLa ...
Tópico(s): Viral Infections and Immunology Research
2003 - Elsevier BV | Journal of Biological Chemistry
... in Certain Circumstances, Possess of Producing Cold. By Adar Crawford, M. D; Communicated by Sir Joseph Banks... ...
1781 - Gale Group | NCCO SciTechMed 2 of 2
Stefan Maas, Alexander Rich, Kazuko Nishikura,
... 324) Google Scholar). Adenosine deaminases acting on RNA (ADARs),1 the enzymes responsible for conversion of A- ... PubMed Scopus (393) Google Scholar). Members of the ADAR gene family share common structural features such as ... Scholar). Certain structural features are unique to particular ADAR members. For instance, ADAR1 contains two Z-DNA ... Scopus (393) Google Scholar). Orthologues of the mammalian ADARs have also been characterized and cloned from fruit ... was uncovered based on their sequence homologies to ADARs. ADAT3 is an adenosine deaminase in yeast shown ...
Tópico(s): RNA modifications and cancer
2003 - Elsevier BV | Journal of Biological Chemistry
Jeremy Rundall, Geoffrey Grigson, L. J. Corbett, Mary Gostelow, Clare Smith, Harold Hobson, Peter Gillman, John Peter, B J Jans, Anthony H Chapman, Graham Rose, Tim Brierly, C. H. O'd. Alesander, Ivor Domb, George Schwartz Column, Moira Keenan, John Whale, Lord Longford, Julian Symons, Jason Tomas, Peter Levi, W H Auden, Philip Oakes, Anne Robinson, Henry Brandon, Christopher Driver, Mark Ottaway, Adam Hopkins, Deryk Brown, Max Marquis, Anne P Reece, Maureen Duffy, Ernie Wise, Cliff Temple, David Tennant, Patrick Campbell, Egon Ronay, Bill Glenton, Margaret Hides, Henry Shapiro, James Tucker, Peter Lennon, Irving Rosenwater, Michael Howard, Raymond Mortimer, John Ball, Clare Colvin, Boris Schapiro, Hilary Macaskill, Rene Lecler, Arthur Eperon, (Miss) A W Morgan, Tony Geraghty, Brian Jackman, Anthony Storr, Molly Parkin, John Hopkins, Eric Jacobs Labour Correspondent, Oscar Turnill, John Barry, Derrik Mercer, Denis Herbstein, Derek Hudson, John Whitley, Robin Fedden, Aziz Khan-Panni, Pamela Vandyke Price, Bryan Silcock, Roger Mortimer, Peter Scott, Ernestine Carter, David Balderstone, Richard Garrick, Sir Matt Busby's, Lyman Andrews, Roy Maddison, Michael Bateman, Bevis Hillier, Gabriel Ronay, Ronald Butt, Dilys Powell, Elkan Allan, David Divine Defence Correspondent, Antonia Cardwell, Angier Biddle Duke, Dudley Doust, Felix Aprahamian, Jack Fingleton, Ian Jack, Stephen Fay, Lewis Chester, Susan Raven, Dr Alfred Byrne Medical Correspondent, Alan West, Peter Pringle, Gary Hope, James Margach Political Correspondent, Derek Humphry, Tony Dawe, Brian Glanville, Graham Searjeant, Peter Dunn, L A T Moss, Dave Phillips, Maurice Wiggin, Stuart Murray, Michael Parkinson, Phillip Knightley, Michael Tennant, Malcolm Crawford, Vincent Hanna, Michael Ward, Muriel Bowen,
... the impenetrable Uganda The A(arhus) to Z(adar) of European ferries Motoring: Four-Page Section Townsend ...
1971 - Gale Group | Sunday Times HA GDA
Pham Nguyet Thi Hang, Michihisa Tohda, Kinzo Matsumoto,
Adenosine deaminase-1 and -2 (ADAR-1 and -2) are double-stranded RNA-specific enzymes involved in the editing of genes including serotonin 2C receptor (5-HT2CR) mRNA and ADAR-2 pre-mRNA. We reported that the editing ... to clarify if changes in the expression of ADAR genes and the editing of ADAR-2 pre-mRNA occur during development. The expression level of ADAR-1 mRNA was constant during development, whereas the expression levels of ADAR-2 mRNA and ADAR-2 pre-mRNA markedly increased during development. ADAR- ...
Tópico(s): CRISPR and Genetic Engineering
2008 - Elsevier BV | Neuroscience Research
Elizabeth Hodder, Srikumar Sen, Boxing Correspondent, David A. Turner, Co-ordinator, Keith Hindley, Daniel Ward, Motor Industry Correspondent, Simon Barnes, Richard Thomson Banking Correspondent, Jonathan Miller, Caroline Phillips, E. Gosling, John Bell, City Editor, Ian Murray, Michael Binyon, Jeremy Kingston, walter Charles dies, Person Phillips, Mandarin (Michael Phillips), John Best, Stuart Jones Football Correspondent, John Clare, Education Correspondent, Geoffrey Smith, Richard Dobson, Joe Joseph, Nichelas Wood Political Reporter, Bryan Stiles, Ruth Gledhill, David Housham, Pearce Wright Science Editor, Lawrence Lever, Thomson Prentice Science Correspondent, Peter Waymark, Robin Young, Martin Cropper, Michael Clark, Martin Fletcher, Political Reporter, (AP), Michael Hamlyn, John Dorman, Andrew Rutherford, Chairman, Rex Bellamy, Barry Fantoni, Charles Bremner, Woodrow Wyatt, John Percival, Mervyn Benford, Alma N. Dax, Ray Tongue, Ronald Davie, Director, Paul Vallely, Sydney Friskin, David Smith, Economics Correspondent, Chris Thau, Mitchell Platts Golf Correspondent, Philip Webster, Chief Political Correspondent, Nicolas Soames, Josephine Fairley, William Greaves, David Watts, Timothy Raison, Dennis Shaw, Craig Brown, Paul Griffiths, Andrew McEwen, Diplomatic Correspondent, Stewart Tendler Crime Reporter, Sheila Gunn, Political Staff, Richard Owen, John Clare Education Correspondent, Stewart Tendler, Crime Reporter, Nina Fishman, Campaign Co-ordinator, David Young, Energy Correspondent, Irving Wardle, Ian Ross, Sarah Thompson Education Reporter, Bryan Appleyard, David Sapsted, Richard Bassett, Brian Beel, Kenneth Fleet, F. W. Sternfeld, Christopher Thomas, Jonathan Miller Media Correspondent, Haringey v Sandhu, Teddy Taylor Secretary, Pat Butcher, Athletics Correspondent, Christopher Walker, Jill Sherman Social Services Correspondent, Mandarin, Edward Townsend, Industrial Correspondent, Clive White, Austin Sammut, Michael Hornsby, Michael Seely, Jane Tait, Director, Alan Lee, Peter Dear and Peter Davalle, George Chesterton, John Woodcock, Cricket Correspondent, Michael Evans Defence Correspondent, Richard Morrison, William Glock, David Black, Colin Campbell, Claus Moser, David Hands, Rugby Correspondent, Mark Law, Regina v Lewes, Richard Ford, Ray Heath,
... Appointments La Manga Club Gordon Yates Office Angels ADAR Multiple Classified Advertising Items La Creme De La ...
1987 - Gale Group | TDA
Heather A. Hundley, Brenda Bass,
ADARs are a family of enzymes, present in all animals, that convert adenosine to inosine within double- ... structure, coding potential and splicing patterns. The first ADAR substrates identified were edited in codons, and ADARs were presumed to function primarily in proteome diversification. Although this is an important function of ADARs, especially in the nervous system, editing in coding ... regulation of a variety of post-transcriptional processes. ADARs are a family of enzymes, present in all ... structure, coding potential and splicing patterns. The first ADAR substrates identified were edited in codons, and ADARs ...
Tópico(s): RNA and protein synthesis mechanisms
2010 - Elsevier BV | Trends in Biochemical Sciences
Srikumar Sen, Boxing Correspondent, Peter Evans Home Affairs Correspondent, P. G., Sheila Gunn, Christopher Warman, Property Correspondent, Patricia Davies, Tony Duboudin, Jo Grimond, Jonathan Miller, Andrew Morgan, Geraldine Norman, Sale Room Correspondent, Cliff Feltham, Philip Howard, John Bell, City Editor, David Hart, Peter Tizard, Tom Harman Smith, Michael Binyon, Jeremy Kingston, Sarah Drummond, Mandarin (Michael Phillips), Carol Leonard, Richard Eaton, Stuart Jones Football Correspondent, Geoffrey Smith, John Spicer, Employment Affairs Correspondent, Joe Joseph, Stephen Taylor, R. O. Shaw K. Nath, Michael Tate, David Housham, David Bernstein, Lawrence Lever, Rodney Cowton, Transport Correspondent, John V. Eibner, Peter Waymark, Michael Evans, Defence Correspondent, Ray Kennedy, Martin Cropper, David Butler, Andrew Wiseman, Diana Geddes, Ian Bradley, David Hands, Joseph Connolly, Richard Evans, Political Correspondent, John Percival, Peter Barnard, Richard Thomson, Banking Correspondent, Peter Lewis, John Hennessy, Robert Fisk Middle East Correspondent, Sophie Witter, Gerald Howat, Jeremy Novick, David Smith, Economics Correspondent, David Miller, Robin Oakley Political Editor, Philip Webster, Chief Political Correspondent, Josephine Fairley, Alan Toogood, Horticulture Correspondent, Nicholas Wood Political Reporter, Robin Oakley, Political Editor, David Robinson, Dennis Shaw, Craig Brown, Zoriana Pysariwsky, Paul Griffiths, Peter Bryan, Alexandra Jackson, Willem Landman, Stewart Tendler Crime Reporter, Richard Evans, J. C. E. Murray, Robert Matthews, John Clare Education Correspondent, Alastair Brett, Irving Wardle, Sarah Thompson Education Reporter, J. J. Czarnowski, David Sapsted, Brian Beel, Charles Knevitt, Architecture Correspondent, Kenneth Fleet, Christopher Thomas, Jonathan Miller Media Correspondent, Christopher Warman Property Correspondent, Christopher Walker, Caroline Thomson, Carol Ferguson, Edward Townsend, Industrial Correspondent, Peter Aykroyd, Mel Webb, Clive White, Michael Hornsby, Michael Seely, Alan Lee, Michael Clark and Geoffrey Foster, Edgar Palamountain, Daniel Ward, Tony Dawe, Sarah Harrison, Russell Hill, David Sinclair, Sue Cameron, Tim Jones, Frances Gibb Legal Affairs Correspondent, David Powell, Hugh Taylor, Harvey Elliott Air Correspondent, Thomson Prentice and Pearce Wright, Colin Campbell, Richard Newby, National Secretary Andrew Ellis, Secretary General, David Hands, Rugby Correspondent, Brian Davis, Tom Bower,
... Middleton Jeffers Recruitment Limited Multiple Classified Advertising Items ADAR Gordon-Yates Recruitment Consultants Chestertons Prudential Elizabeth Hunt ...
1987 - Gale Group | TDA
James E.C. Jepson, Yiannis A. Savva, Chio Yokose, Arthur U. Sugden, Aslı Şahin, Robert A. Reenan,
... to inosine by adenosine deaminases acting on RNA (ADARs). It has been hypothesized that this process, termed ... However, the extreme phenotypes resulting from deletions of adar loci have precluded investigations into the relationship between ADAR levels, target transcripts, and complex behaviors. Here, we engineer Drosophila hypomorphic for ADAR expression using homologous recombination. A substantial reduction in ADAR activity (>80%) leads to altered circadian motor patterns ... is spared. The altered phenotypic landscape in our adar hypomorph is paralleled by an unexpected dichotomous response ...
Tópico(s): RNA and protein synthesis mechanisms
2010 - Elsevier BV | Journal of Biological Chemistry
Giles Smith, Gráinne Gilmore, Andrew Robson, Janice Turner, Gabriele Marcotti, Christina Hardyment, Cath Urquhart, Robert Cole, Myra Van Hus, Matthew Syed, Bill Corcoran, David Brown, Leo Lewis Asia Business Correspondent, John Sims, Ken Patel, Frances Gibb Legal Editor, Simon Barnes, Amanda Ursell, Michael Apted, Jane MacQuitty, Peter Lansley, Jasper Rees, Simon Hills, Jan Morris, Robert Lindsay, Mark Frary, Richard Hobson, David Rose, Terry Eagleton, John Mulvey, Jane Knight, Ivo Tennant, Clare Lazaro, Emma Cook, D. R. Myddelton, Dr Toby Murcott, Philip Howard, David Lyon, Anthony Serrano, Hannah Betts, Julia Brookes, Malcolm Pye, Kevin O'Flynn, Lee Child, Christine Seib, Elizabeth Garner, Carol Midgley, Kate Wighton, Joanna Bale, James Bone, Michael Binyon, Melissa Katsoulis, Tahmima Anam, Dominic Wells, Clive Davis, Rachel Campbell-Johnston, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Ross Fortune, Gabrielle Starkey, Frances Welch, Carl Mortished, Kevin Brownlow, Will Pavia, Graham Stewart, Martin Aston, Sam Marlowe, Wendy Ide, James Hider, John Bungey, Stephen Baker, Juliet Kinsman, Andrew Norfolk, Giles Coren, Mr S. Massey, Caroline Hendrie, Martin Fletcher, Dr Copperfield, William Jones, Valerie Elliott Countryside Editor, Pat Gibson, Matt Sandy, Stephen McClarence, Roddy Waldhelm, Anthony Werner, Michael Byrnes, Ron Matthews, John Clarke, Siobhan Kennedy, Jack Malvern, Tom Bawden, James cotton specialist, Dan Sabbagh Media Editor, William Dalrymple, Debra Craine, Jim Peace, Mike Pattenden, James Purefoy, Allan Simmons, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Jeanette Winterson, James Attlee, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Sir Walter Raleigh, Sarah Dempster, Tom Gatti, Candida Crewe, Jo Morris, Peter Millar, David Sharrock Ireland Correspondent, Elizabeth Colman, Helen Dunmore, Christopher Tolley, Phil Gordon, Rhys Blakely, Richard Lloyd Parry, Naomi Campbell, Charles Bremner, Ron Lewis, Martin Symington, Helen Rumbelow, Adam Sherwin Media Correspondent, Matt Dickinson Chief Football Correspondent, Michael Pennington, Lucy Sweeney, Greg Hurst, David Charter, Tim Teeman, Sue Boothroyd, Derwent May, Kate Muir, Tim de Lisle, Aggie MacKenzie, Russell Kempson, Paula Hawkins, Mary Gold, Tom Whitwell, Ed Potton, Carola Long, Oliver Kay, Gerard Baker, Penny Vincenzi, Stephen Anderton, David Lister, Mark Atherton, Lisa Armstrong, John Westerby, Sarah Vine, Rick Broadbent, Julian Evans, Jane Wheatley, Tom Baldwin, James Rossiter, David Lawrenson, Antonia Senior Personal Finance Editor, Christopher Martin-Jenkins, Sally Baker, Chris Power, Pete Paphides, Simon de Bruxelles, Rob Wright, Geoffrey Dean, ZoË Strimpel, James Jackson, Christina Koning, Alex Salmond, Neil Harman Tennis Correspondent, E. Anne Webb, Raymond Keene, Ewart Richards, Suzi Godson, Kate Saunders, Matthew Pryor, Richard Brass, Matt Hughes, Rebecca O'Connor, Sarah Birke, Gordon Ramsay, Ffian Hague, Christine Buckley Industrial Editor, Sean O'Neill, Peta Bee, Rick Jones, Andrew G. Marshall, Chris Campling, Fran Yeoman, David Chater, David Malaperiman, Helen Nugent, Laura Deeley, Christopher Martin-Jenkins Chief Cricket Correspondent, Marcus Leroux, Ross Leckie, Erica Wagner, Roger Boyes, Michael Fishpool, Peter Dixon, Thomasina Miers, Graham Searjeant Personal Investor, Joanna Moorhead, Margaret Reynolds, David Hands Rugby Correspondent, Kevin Maher, James Collard, Marilyn Stowe, Paul Simons, Mike Mulvihill, Nicholas Clee, Jon Deans, Nancy Durrant, Nigel Kendall, Nick Szczepanik, John Goodbody, Joanna Pitman, Tom Broker, Nick Parkhouse associate director, Steve Hawkes, Anna Stroman, Robert Crampton, Maxine Thrasher, Thomas Catán, Ian Johns, Dominic Maxwell, Alice Fordham, Guy Liardet, Matthew Parris, Mark Bridge, Virginia Blackburn, David Crossland, David Heath, Bill Rammell, MP, Amanda Craig, George Caulkin, Alison Steed, Tim Wapshott, Russell Jenkins, Caitlin Moran, Sheila Keating, Celia Dodd, Neil Fisher, Iain Finlayson, Peter Riddell, Ben MacIntyre, Andrew Ellson, Helen Pridham, Mike Atherton, Professor Yellowlees, Richard Beeston, Sofka Zinovieff, Rob Nash, Richard Beeston Diplomatic Editor, David Hutcheon, Lucia van der Post, John Naish, Martin Waller, Mark Henderson, Michael Horsnell, Lewis Smith Environment Reporter, Chris Ayres, Geert Mak, Patrick Foster, Kate Quill, David Mcclelland, Sarah Butler, Hugo Vickers, Louise Cohen, Shaul Adar, Benedict Nightingale, Angus Batey, Brian Logan, Rod Morris, Dr Thomas Stuttaford, Jill Crawshaw, Derek Arthur, Stephen Dalton, Richard Morrison, James Christopher, Alice Miles, Philip M. Correll, Peter J. M. Wayne, Simon Crompton, Alan Jackson, Olav Bjortomt, Cath Urquhart Travel Editor, Kim Newman, Tony Wilson, Lord Crisp, David Robertson, Bryce Elder, Lucy Freeman, Ed Hughes, Tony H. H. Richardson, Joe Bolger, Christopher Irvine, Elizabeth Judge Telecoms Correspondent,
Index Hostage fears over troops seized by Iran 15 servicemen held as 'pawns' in nuclear row Tehran arrests men for entering illegally Index Comment World ...
2007 - Gale Group | TDA
Jeffrey W. Habig, Taraka Dale, Brenda Bass,
... that editing of a microRNA (miRNA) precursor by ADARs can modulate the target specificity of the mature ... that editing of a microRNA (miRNA) precursor by ADARs can modulate the target specificity of the mature ... catalyzed by adenosine deaminases that act on RNA (ADARs). As double-stranded RNA binding proteins (dsRBPs), ADARs bind their substrates based upon structure rather than ... pairing specificity. Consequently, several labs have investigated if ADARs edit miRNA precursors and whether this influences miRNA ...
Tópico(s): CRISPR and Genetic Engineering
2007 - Elsevier BV | Molecular Cell
Diane Wu, Ayelet T. Lamm, Andrew Fire,
ADARs deaminate adenosines to inosines in double-stranded RNA (dsRNA). Interestingly, effects seen when ADARs are knocked out can be suppressed by additional ... between the two pathways. Genome-wide identification of ADAR targets shows that ADAR edits heavily in regions that generate siRNAs when ADAR is absent, indicating a role for ADAR in regulating dsRNA accumulation and thus siRNA production. Adenosine deaminases that act on RNAs (ADARs) interact with double-stranded RNAs, deaminating adenosines to ...
Tópico(s): RNA and protein synthesis mechanisms
2011 - Nature Portfolio | Nature Structural & Molecular Biology
Simona Paro, Xianghua Li, Mary A. O’Connell, Liam P. Keegan,
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing. We discuss the roles of ADAR in Drosophila in terms of the two main types of RNA molecules edited and roles of ADARs as RNA-binding proteins. Site-specific RNA editing ... consistently produce a particular outcome such as making Adar mutant neurons more excitable. This possibility would have ...
Tópico(s): RNA Research and Splicing
2011 - Springer Science+Business Media | Current topics in microbiology and immunology
Q. Liu, Luo Jiang, W.‐L. Liu, X-J. Kang, Ao Yang, Miao Sun, Yang Luo, Yong Song, Wilson H.Y. Lo, Xinan Zhang,
... dominantly inherited skin disease associated with mutations in ADAR, the gene that encodes a double‐stranded RNA‐specific adenosine deaminase. We previously reported two novel ADAR mutations (p.Q513X and p.R916W) and confirmed the role of ADAR in Chinese patients with DSH. Both haploinsufficiency and ... been suggested as the potential mechanism by which ADAR mutations cause DSH. Objectives To identify ADAR mutations in two additional Chinese DSH families and ... obtain insight into the pathogenic mechanism of heterozygous ADAR mutations. Methods For mutation detection, all ADAR exons ...
Tópico(s): RNA Research and Splicing
2006 - Oxford University Press | British Journal of Dermatology
Yiannis A. Savva, Leila E. Rieder, Robert A. Reenan,
... of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction. All ADARs share a common domain architecture consisting of a ... dsRBDs) and a carboxy-terminal catalytic deaminase domain. ADAR family members are highly expressed in the metazoan ... to the neuronal nucleus. Once in the nucleus, ADARs participate in the modification of specific adenosines in ... model organisms bear out a crucial role for ADARs in nervous system function. Mutation or deletion of ADAR genes results in striking phenotypes, including seizure episodes, ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - Springer Science+Business Media | Genome Biology
Liam P. Keegan, James Brindle, Angela Gallo, Anne Leroy, Robert A. Reenan, Mary A. O’Connell,
... May 2005free access Tuning of RNA editing by ADAR is required in Drosophila Liam P Keegan Corresponding ... neurotransmission in Drosophila central nervous system and muscle. Adar (adenosine deaminase acting on RNA) mutant flies expressing ... are viable but show severe locomotion defects. The Adar transcript itself is edited in adult wild-type ... a serine to glycine substitution close to the ADAR active site. We show that editing restricts ADAR function since the edited isoform of ADAR is less active in vitro and in vivo ...
Tópico(s): CRISPR and Genetic Engineering
2005 - Springer Nature | The EMBO Journal
Noa Liscovitch, Lily Bazak, Erez Y. Levanon, Gal Chechik,
... to examine the relation between the expression of ADAR genes with the expression of their target genes. ... across structures of post-mortem human brains between ADAR and a large set of targets that were ... of the edited genes are positively correlated with ADAR, opposing the assumption that editing would reduce expression. When considering the correlations between ADAR and its targets over development, 2 gene subsets emerge, positively correlated and negatively correlated with ADAR expression. Specifically, in embryonic time points, ADAR is ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Taylor & Francis | RNA Biology
William Slotkin, Kazuko Nishikura,
... and noncoding RNA transcripts. It is catalyzed by ADAR (adenosine deaminase acting on RNA) enzymes, which exist ... similar to those of guanosines. As a result, ADAR-mediated editing can post-transcriptionally alter codons, introduce ... the transcriptome, but the full biological significance of ADARs is not understood. ADARs are highly conserved across vertebrates and are essential for normal development in mammals. Aberrant ADAR activity has been associated with a wide range ... disorders, metabolic diseases, viral infections and autoimmune disorders. ADARs have been shown to contribute to disease pathologies ...
Tópico(s): RNA modifications and cancer
2013 - BioMed Central | Genome Medicine
Laura F. Grice, Bernard M. Degnan,
ADAR (adenosine deaminase acting on RNA) proteins convert adenosine into inosine in double-stranded RNAs and have ... double-stranded RNA binding domain. The modern vertebrate ADAR family is comprised of ADAD, ADAR2 and ADAR1, ... of this protein family, we identified and categorised ADAR family members encoded in the genomes and/or ... and ten ctenophore species. We demonstrate that the ADAR protein family is a metazoan innovation, with the three ADAR subtypes being present in representatives of the earliest ...
Tópico(s): interferon and immune responses
2015 - Springer Science+Business Media | BMC Evolutionary Biology
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O’Connell,
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications ... it were guanosine. In mammals there are three ADAR proteins and two ADAR-related proteins (ADAD) expressed. All have a very ... biological function differ significantly. Only two of the ADAR proteins have enzymatic activity. However, both ADAR and ADAD proteins possess the ability to bind double-strand RNA. Mutations in ADARs have been associated with many diseases ranging from ... discuss in detail the domain structure of mammalian ADARs, the effects of RNA editing, and the role ...
Tópico(s): RNA and protein synthesis mechanisms
2015 - Multidisciplinary Digital Publishing Institute | Biomolecules
Helen Piontkivska, Luis F. Matos, Sinu Paul, Brian Scharfenberg, William G. Farmerie, Michael M. Miyamoto, Marta L. Wayne,
... mediated, selective RNA editing of adenosines to inosines (ADAR) may contribute to control of viral infection by ... mutation rate. Previous PCR-based studies showed that ADAR mutations occur in DMelSV at low frequency. Here ... of sequence variation in DMelSV with respect to ADAR. GA dinucleotides, which are weak targets of ADAR, are strongly overrepresented in the positive strand of the virus, consistent with selection to generate ADAR resistance on this complement of the transient, double-stranded RNA intermediate in replication and transcription. Potential ADAR sites in a worldwide sample of viruses are ...
Tópico(s): CRISPR and Genetic Engineering
2016 - Oxford University Press | Genome Biology and Evolution
... discovery of adenosine deaminases that act on RNA (ADARs). Although inosine monophosphate (IMP) cannot be detected in ... specific levels that correlate with the levels of ADAR mRNA expression. The amount of IMP present in ... discovery of adenosine deaminases that act on RNA (ADARs; Bass and Weintraub, 1988; Melcher et al., 1996; ... 1997) have been proposed to be edited by ADARs in vivo. For each of these RNAs, adenosine ... B, 5HT2C and HDV antigenomic RNAs with various ADARs leads to deamination of adenosines at the proposed ...
Tópico(s): RNA and protein synthesis mechanisms
1998 - Springer Nature | The EMBO Journal
Chen Wang, Jun Zou, Xiangyi Ma, Eddie C. Y. Wang, Guang Peng,
Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNAs. Inosine exhibits similar properties as ... diversify transcripts. However, the overall biological effect of ADARs are still largely unknown. Aberrant ADAR activity and editing dysregulation are present in a ... hepatocellular carcinoma, chronic myelogenous leukemia, glioblastoma and melanoma. ADAR-mediated A-to-I editing can influence uncontrolled ... A deeper understanding of the biological function of ADARs may provide mechanistic insights in the development of ...
Tópico(s): RNA Research and Splicing
2017 - Elsevier BV | Cancer Letters