... Alaa, José Oliveira-Pinto, Marta Tavares-Silva, Dulce Fontoura, Inês Falcão-Pires, Adelino F. Leite-Moreira, and André P. Lourenço1 January ...
Tópico(s): Diet, Metabolism, and Disease
1929 - American Physiological Society | American Journal of Physiology-Legacy Content
Chris Van Dijk, Nynke R. Oosterhuis, Yan Xu, Maarten M. Brandt, Walter J. Paulus, Loek van Heerebeek, Dirk J. Duncker, Marianne C. Verhaar, Dulce Fontoura, André P. Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Jaap A. Joles, Caroline Cheng,
Background— The combination of cardiac and renal disease driven by metabolic risk factors, referred to as cardiorenal metabolic syndrome (CRMS), is increasingly recognized as a critical pathological entity. The contribution of (micro)vascular injury to CRMS is considered to be substantial. However, mechanistic studies are hampered by lack of in vivo models that mimic the natural onset of the disease. Here, we evaluated the coronary and renal microvasculature during CRMS development in obese diabetic ...
Tópico(s): Cardiovascular Disease and Adiposity
2016 - Lippincott Williams & Wilkins | Circulation Heart Failure
Sara Leite, José Oliveira‐Pinto, Marta Tavares-Silva, Mahmoud Abdellatif, Dulce Fontoura, Inês Falcão‐Pires, Adelino Leite‐Moreira, André P. Lourenço,
Inclusion of exercise testing in diagnostic guidelines for heart failure with preserved ejection fraction (HFpEF) has been advocated, but the target population, technical challenges, and underlying pathophysiological complexity raise difficulties to implementation. Hemodynamic stress tests may be feasible alternatives. Our aim was to test Trendelenburg positioning, phenylephrine, and dobutamine in the ZSF1 obese rat model to find echocardiographic surrogates for end-diastolic pressure (EDP) elevation ...
Tópico(s): Advanced MRI Techniques and Applications
2015 - American Physical Society | AJP Heart and Circulatory Physiology
André P. Lourenço, Dulce Fontoura, Tiago Henriques‐Coelho, Adelino Leite‐Moreira,
Pulmonary hypertension (PH), increasingly recognized as a major health burden, remains underdiagnosed due mainly to the unspecific symptoms. Pulmonary arterial hypertension (PAH) has been extensively investigated. Pathophysiological knowledge derives mostly from experimental models. Paradoxically, common non-PAH PH forms remain largely unexplored. Drugs targeting lung vascular tonus became available during the last two decades, notwithstanding the disease progresses in many patients. The aim of this ...
Tópico(s): Cardiomyopathy and Myosin Studies
2011 - Elsevier BV | International Journal of Cardiology
Sara Leite, Liliana Moreira‐Costa, Rui Cerqueira, Cláudia Sousa-Mendes, António Angélico‐Gonçalves, Dulce Fontoura, Francisco Vasques‐Nóvoa, Adelino Leite‐Moreira, André P. Lourenço,
Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with preserved ejection fraction (HFpEF), randomized clinical trials (RCTs) with type-5 phosphodiesterase inhibitors (PDE5i) showed neutral results. Whether specific subgroups of HFpEF patients may benefit from PDE5i remains to be defined. Our aim was to test chronic sildenafil therapy in the young male ZSF1 obese rat model of HFpEF with severe hypertension and metabolic syndrome. Sixteen- ...
Tópico(s): Cardiovascular Function and Risk Factors
2021 - SAGE Publishing | Journal of Cardiovascular Pharmacology and Therapeutics
Mahmoud Abdellatif, Sara Leite, Mohamed Alaa, José Oliveira‐Pinto, Marta Tavares-Silva, Dulce Fontoura, Inês Falcão‐Pires, Adelino Leite‐Moreira, André P. Lourenço,
Preserved ejection fraction heart failure (HFpEF) diagnosis remains controversial, and invasive left ventricular (LV) hemodynamic evaluation and/or exercise testing is advocated by many. The stiffer HFpEF myocardium may show impaired stroke volume (SV) variation induced by fluctuating LV filling pressure during ventilation. Our aim was to investigate spectral transfer function (STF) gain from end-diastolic pressure (EDP) to indexed SV (SV i ) in experimental HFpEF. Eighteen-week-old Wistar-Kyoto (WKY) and ...
Tópico(s): Heart Rate Variability and Autonomic Control
2015 - American Physical Society | AJP Heart and Circulatory Physiology
Patrícia Gonçalves‐Rodrigues, Daniela Miranda‐Silva, Sofia M. Costa, Carla Barros, Nazha Hamdani, Cláudia Moura, Maria José Mendes, Cláudia Sousa-Mendes, Fábio Trindade, Dulce Fontoura, Rui Vitorino, Wolfgang A. Linke, Adelino Leite‐Moreira, Inês Falcão‐Pires,
Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO-induced heart failure (DOXO-HF)] or with an equivolumetric dose of saline (control). Echocardiographic evaluation was performed, and myocardial samples were ...
Tópico(s): Cardiomyopathy and Myosin Studies
2018 - American Physical Society | AJP Heart and Circulatory Physiology
Sara Leite, Sara Rodrigues, Marta Tavares-Silva, José Oliveira‐Pinto, Mohamed Alaa, Mahmoud Abdellatif, Dulce Fontoura, Inês Falcão‐Pires, Thierry Gillebert, Adelino Leite‐Moreira, André P. Lourenço,
Myocardial stiffness and upward-shifted end-diastolic pressure-volume (P-V) relationship (EDPVR) are the key to high filling pressures in heart failure with preserved ejection fraction (HFpEF). Nevertheless, many patients may remain asymptomatic unless hemodynamic stress is imposed on the myocardium. Whether delayed relaxation induced by pressure challenge may contribute to high end-diastolic pressure (EDP) remains unsettled. Our aim was to assess the effect of suddenly imposed isovolumic afterload ...
Tópico(s): Advanced MRI Techniques and Applications
2015 - American Physical Society | AJP Heart and Circulatory Physiology
André P. Lourenço, Francisco Vasques‐Nóvoa, Dulce Fontoura, Carmen Brás‐Silva, Roberto Roncon‐Albuquerque, Adelino Leite‐Moreira,
Western-type diets (WD) constitute risk factors for disease but may have distinct effects in heart failure (HF) with cardiac cachexia (CC). We evaluated hemodynamic, metabolic, and inflammatory effects of short-term WD intake in pulmonary hypertension (PH) with CC. Male Wistar rats randomly received 60 mg · kg-1monocrotaline (M) or vehicle (C) and consumed either a 5.4-kcal · g-1WD (35% animal fat, 35% simple carbohydrate, 20% protein, 0.4% Na+) or a 2.9-kcal · g-1(3% vegetable fat, 60% complex carbohydrate, ...
Tópico(s): MicroRNA in disease regulation
2011 - Elsevier BV | Journal of Nutrition
André P. Lourenço, Francisco Vasques‐Nóvoa, José Oliveira‐Pinto, Dulce Fontoura, Roberto Roncon‐Albuquerque, Adelino Leite‐Moreira,
Chronic pulmonary hypertension (PH) therapy is poorly investigated in intensive care. Our aim was to evaluate haemodynamic and neuroendocrine effects of the dual endothelin-1 (ET-1) blocker tezosentan in monocrotaline (MCT)-induced PH.Male Wistar rats (180-200 g, n = 194) randomly received 60 mg kg(-1) MCT or vehicle, subcutaneously, and 2 days later, a subgroup of MCT-injected rats was gavaged with 300 mg kg(-1) day(-1) bosentan (MCT BOS, n = 46), while another (MCT, n = 125) and control rats (Ctrl, n = 23) received ...
Tópico(s): Asthma and respiratory diseases
2012 - Springer Science+Business Media | Intensive Care Medicine
Sara Leite, Rui Cerqueira, Jaime Ibarrola, Dulce Fontoura, Amaya Fernández‐Celis, Faı̈ez Zannad, Inês Falcão‐Pires, Walter J. Paulus, Adelino Leite‐Moreira, Patrick Rossignol, Natalia López‐Andrés, André P. Lourenço,
Background: The interplay between the stiffened heart and vessels has long been viewed as a core mechanism in heart failure with preserved ejection fraction, but the incremental vascular molecular remodeling mechanisms from systemic arterial hypertension to heart failure with preserved ejection fraction remain poorly investigated. Our aim was to characterize central arterial remodeling and dysfunction in ZSF1 obese rats and to compare it with hypertensive ZSF1 lean and healthy Wistar-Kyoto controls. ...
Tópico(s): Cardiac Fibrosis and Remodeling
2019 - Lippincott Williams & Wilkins | Circulation Heart Failure
Marta Borges‐Canha, José Pedro Portela-Cidade, Glória Conceição, Cláudia Sousa-Mendes, Sara Leite, Dulce Fontoura, Daniel Moreira‐Gonçalves, Inês Falcão‐Pires, André P. Lourenço, Adelino Leite‐Moreira, Pedro Pimentel‐Nunes,
The non-alcoholic fatty liver disease is the hepatic counterpart of the metabolic syndrome. ZSF1 rats are a metabolic syndrome animal model in which liver changes have not been described yet.The characterization of liver histological and innate immunity changes in ZSF1 rats.Five groups of rats were included (n = 7 each group): healthy Wistar-Kyoto control rats (Ctrl), hypertensive ZSF1 lean (Ln), ZSF1 obese rats with a normal diet (Ob), ZSF1 obese rates with a high-fat diet (Ob-HFD), and ZSF1 obese rats ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2017 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Dulce Fontoura, José Oliveira‐Pinto, Marta Tavares-Silva, Sara Leite, Francisco Vasques‐Nóvoa, Pedro Mendes‐Ferreira, André P. Lourenço, Adelino Leite‐Moreira,
Endothelin-1 antagonists are increasingly used in the treatment of pulmonary hypertension despite the lack of knowledge of their myocardial and systemic effects. We assessed the right ventricular myocardial and systemic effects of endothelin-1 antagonists in monocrotaline-induced pulmonary hypertension. Male Wistar rats (180–200 g, n=57) randomly received 60 mg/kg monocrotaline or vehicle subcutaneously. Two days later, bosentan was randomly started (300 mg/kg/day) by oral route in a subgroup of monocrotaline- ...
Tópico(s): Cardiovascular Issues in Pregnancy
2014 - Elsevier BV | Revista Portuguesa de Cardiologia
Nazha Hamdani, Constantijn Franssen, André P. Lourenço, Inês Falcão‐Pires, Dulce Fontoura, Sara Leite, Luisa Plettig, Begoña López, Coen A. C. Ottenheijm, Peter Moritz Becher, Arantxa González, Carsten Tschöpe, Javier Dı́ez, Wolfgang A. Linke, Adelino Leite‐Moreira, Walter J. Paulus,
Background— Obesity and diabetes mellitus are important metabolic risk factors and frequent comorbidities in heart failure with preserved ejection fraction. They contribute to myocardial diastolic dysfunction (DD) through collagen deposition or titin modification. The relative importance for myocardial DD of collagen deposition and titin modification was investigated in obese, diabetic ZSF1 rats after heart failure with preserved ejection fraction development at 20 weeks. Methods and Results— Four ...
Tópico(s): Cardiomyopathy and Myosin Studies
2013 - Lippincott Williams & Wilkins | Circulation Heart Failure
Rita Nogueira‐Ferreira, Inês Maria Meneses dos Santos, Rita Ferreira, Dulce Fontoura, Cláudia Sousa-Mendes, Inês Falcão‐Pires, André P. Lourenço, Adelino Leite‐Moreira, Iola F. Duarte, Daniel Moreira‐Gonçalves,
Metabolic syndrome (MetS), characterized by a set of conditions that include obesity, hypertension, and dyslipidemia, is associated with increased cardiovascular risk. Exercise training (EX) has been reported to improve MetS management, although the underlying metabolic adaptations that drive its benefits remain poorly understood. This work aims to characterize the molecular changes induced by EX in skeletal muscle in MetS, focusing on gastrocnemius metabolic remodelling. 1H NMR metabolomics and molecular ...
Tópico(s): Biochemical effects in animals
2023 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
André P. Lourenço, Inês Falcão‐Pires, Rui Cerqueira, Dulce Fontoura, Daniela Miranda, Nazha Hamdani, Walter J. Paulus, Adelino Leite‐Moreira,
Diastolic dysfunction, characterized by relaxation abnormalities and increased myocardial stiffness, and heart failure with preserved ejection fraction (HFpEF) are increasingly prevalent in Western...
Tópico(s): Cardiovascular Function and Risk Factors
2012 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
Alexandra S. Rashedi, Saskia F. de Roo, Lauren Ataman, Maxwell E. Edmonds, Adelino Amaral Silva, Aníbal Scarella, Anna Horbaczewska, Antoinette Anazodo, Ayşe Arvas, Bruno Ramalho de Carvalho, Cássio Sartório, C. C. M. Beerendonk, César Díaz‐García, Chang Suk Suh, Cláudia Melo, Claus Yding Andersen, E.L.A. Motta, Ellen Greenblatt, Ellen Van Moer, Elnaz Zand, Fernando M. Reis, F. Guerrero Sánchez, Guillermo Terrado, Jhenifer Kliemchen Rodrigues, João Marcos de Meneses e Silva, Johan Smitz, José V. Medrano, Jung Ryeol Lee, Katharina Winkler-Crepaz, Kristin Smith, Lígia Helena Ferreira Melo e Silva, L. Wildt, Mahmoud Salama, María del Mar Andrés, María T. Bourlon, Mario Vega, Maurício B. Chehin, Michel De Vos, Mohamed Khrouf, Nao Suzuki, Osama Azmy, Paula Fontoura, Paulo Henrique Almeida Campos-Júnior, Peter Mallmann, Ricardo Azambuja, Ricardo Mello Marinho, Richard A. Anderson, Robert Jach, Roberto de Azevedo Antunes, Rod T. Mitchell, Rouhollah Fathi, Satish Kumar Adiga, Seido Takae, Seok Hyun Kim, Sergio Romero, Silvana Chedid Grieco, Talya Shaulov, Tatsuro Furui, Teresa Almeida‐Santos, W. L. D. M. Nelen, Yasmin Jayasinghe, Yodo Sugishita, Teresa K. Woodruff,
Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale.Survey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health-funded organization. Responses were analyzed to ...
Tópico(s): Ovarian function and disorders
2017 - Lippincott Williams & Wilkins | JCO Global Oncology
Produção Nacional
Revisado por pares
Alexandra S. Rashedi, Saskia F. de Roo, Lauren Ataman, Maxwell E. Edmonds, Adelino Amaral Silva, Aníbal Scarella, Anna Horbaczewska, Antoinette Anazodo, Ayşe Arvas, Bruno Ramalho de Carvalho, Cássio Sartório, C. C. M. Beerendonk, César Díaz‐García, Chang Suk Suh, Cláudia Melo, Claus Yding Andersen, E.L.A. Motta, Ellen Greenblatt, Ellen Van Moer, Elnaz Zand, Fernando M. Reis, F. Guerrero Sánchez, Guillermo Terrado, Jhenifer Kliemchen Rodrigues, João Marcos de Meneses e Silva, Johan Smitz, José V. Medrano, Jung Ryeol Lee, Katharina Winkler-Crepaz, Kristin Smith, Lígia Helena Ferreira Melo e Silva, L. Wildt, Mahmoud Salama, María del Mar Andrés, María T. Bourlon, Mario Vega, Maurício B. Chehin, Michel De Vos, Mohamed Khrouf, Nao Suzuki, Osama Azmy, Paula Fontoura, Paulo Henrique Almeida Campos-Júnior, Peter Mallmann, Ricardo Azambuja, Ricardo Mello Marinho, Richard A. Anderson, Robert Jach, Roberto de Azevedo Antunes, Rod T. Mitchell, Rouhollah Fathi, Satish Kumar Adiga, Seido Takae, Seok Hyun Kim, Sergio Romero, Silvana Chedid Grieco, Talya Shaulov, Tatsuro Furui, Teresa Almeida‐Santos, W. L. D. M. Nelen, Yasmin Jayasinghe, Yodo Sugishita, Teresa K. Woodruff,
Purpose In the accompanying article, “Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2017 - Lippincott Williams & Wilkins | JCO Global Oncology
Ondřej Naňka, Éric Krejci, Z. Pesevski, David Sedmera, N. S. Smart, A. Rossdeutsch, Katharina Dube, J. Riegler, Amy Price, Amanda Taylor, Vivek Muthurangu, Margaret Turner, Mark F. Lythgoe, P. R. Riley, S. Kryvorot, Т. Е. Vladimirskaya, И. А. Швед, Michael Schwarzl, Sarah E. Seiler, Sabrina Huber, Paul Steendijk, H. Maechler, M. Truschnig‐Wilders, Burkert Pieske, Heiner Post, C. Caprio, Alessandra Baldini, E. Chiavacci, L. Dolfi, L. Verduci, F. Meghini, F. Cremisi, Letizia Pitto, T.-C. Kuan, M.-C. Chen, T.-H. Yang, Wenqing Wu, Chi-Syan Lin, H. Rai, Shailendra Kumar, Atul Sharma, Sarabjit Mastana, Arjun Kapoor, C. M. Pandey, Satish C Agrawal, N. Sinha, E. H. Orlowska-Baranowska, G. Placha, JoAnn Gennaro Gora, Robert L. Baranowski, E. Abramczuk, Tomasz Hryniewiecki, Zbigniew Gaciong, Jeffrey J. W. Verschuren, Judith A.M. Wessels, Stella Trompet, David J. Stott, N Sattar, Barbara E. Buckley, Henk‐Jan Guchelaar, J. Wouter Jukema, M. Gharanei, Afzal Hussain, C. J. Mee, Helen Maddock, Wino J. Wijnen, S. Van Den Oever, Ingeborg van der Made, Maximilian Hiller, Anke J. Tijsen, Yigal M. Pinto, Esther E. Creemers, S. U. Y. Nikulina, А. А. Чернова, Andreas Petry, Tomasz Rzymski, Damir Kračun, Florian Rieß, L. A. Pike, Amy Harris, Agnes Görlach, Rajesh Katare, A. Oikawa, Federica Riu, Antonio Paolo Beltrami, D. Cesseli, Costanza Emanueli, Paolo Madeddu, Tania Zaglia, Giulia Milan, M. Franzoso, P. Pesce, C. Sarais, M. Sandri, Marco Mongillo, Tom Butler, A-M Seymour, D. Ashford, Fabrice Jaffré, M. Bussen, I. Flohrschutz, Georgiana Martin, Stefan Engelhardt, Georgios Kararigas, B. T. Nguyen, Hubertus Jarry, Vera Regitz‐Zagrosek, Marc van Bilsen, Amanda Daniels, Chantal Munts, Ben Janssen, Ger J. Vusse, Frans A. van Nieuwenhoven, C. Montalvo, Aitor Villar-Martínez, D. Merino, Ralph Garcia, Martín de Llano, Mikko P.S. Ares, María A. Hurlé, J. F. Nistal, A. Dembińska-Kieć, B. K. W. Beata Kiec-Wilk, A. P. Anna Polus, Urszula Czech, T. K. Tatiana Konovaleva, G. S. Gerd Schmitz, Lewis Bertrand, Magali Balteau, Aurélie Timmermans, Benoı̂t Viollet, Kimihiko Sakamoto, Olivier Féron, S. Horman, Jean‐Louis Vanoverschelde, C. Beauloye, Carole de Meester, Elizabeth Martinez, Richard P. Martin, María Miana, R. Jurado, Nieves Gómez‐Hurtado, María Visitación Bartolomé, J. A. San Roman, Vicente Lahera, Marı́a Luisa Nieto, Victoria Cachofeiro, Francesca Rochais, R. Sturny, Karim Mesbah, Lucile Miquerol, Robert G. Kelly, Smail Messaoudi, Basile Gravez, A. Tarjus, Véronique Pelloux, J. L. Samuel, Claude Delcayre, J.M. Launay, Kristina Clement, Nicolette Farman, F. Jaisser, L. Hadyanto, C. Castellani, Giorgio Vescovo, Barbara Ravara, R. Tavano, M. Pozzobon, P. De Coppi, Enrico Papini, Roberto Vettor, Gaetano Thiene, Annalisa Angelini, M. Meloni, Andrea Caporali, Daniela Cesselli, O. Fortunato, Elisa Avolio, Paolo Madeddu, Antonio Paolo Beltrami, Costanza Emanueli, Ralf Schindler, Subreena Simrick, Thomas Brand, Katharina Dube, P. R. Riley, N. S. Smart, A. Oikawa, Rajesh Katare, A Herman, Costanza Emanueli, Paolo Madeddu, Santiago Roura, Joana Bago, Carolina Soler‐Botija, J. M. Pujal, Carolina Gálvez‐Montón, Cristina Prat‐Vidal, Aida Lluciá‐Valldeperas, José Carlos Casas Blanco, Antoni Bayés‐Genís, G. Foldes, Maxime Maignan, Nahid Ali, Michel Schneider, S. E. Harding, C. Reni, G. Mangialardi, Andrea Caporali, M. Meloni, Costanza Emanueli, Paolo Madeddu, Aurélia De Pauw, B. Sekkali, A. Friart, He-Yuang Ding, A. Graffeuil, D. Catalucci, Jean‐Luc Balligand, Fériel Azibani, François Tournoux, S. Schlossarek, Evelyne Polidano, Loubina Fazal, Régine Merval, Lucie Carrier, Christos Chatziantoniou, J. L. Samuel, Claude Delcayre, Byambajav Buyandelger, Wolfgang A. Linke, Patrick X.W. Zou, Sergei Kostin, Chai Siah Ku, Leanne E. Felkin, Emma J. Birks, Paul E. Barton, Matteo C. Sattler, R. Knoell, Katrin Schröder, Sebastian Benkhoff, Hitoyata Shimokawa, Olaf Grisk, Ralf P. Brandes, Irinel-Raluca Parepa, Laura Mazilu, Andra‐Iulia Suceveanu, Andra‐Iulia Suceveanu, L. Rusali, Lucia Cojocaru, L. Matei, M. Toringhibel, Elvira Craiu, Ana Luísa Pires, Marisa Pinho, Sonia de Castro Pinho, Cristina M. Sena, Raquel Seiça, Adelino Leite‐Moreira, Tania Zaglia, Giulia Milan, M. Franzoso, F. Dabroi, P. Pesce, Stefano Schiaffino, M. Sandri, Marco Mongillo, Елена Киселева, N. Krukov, O. Nikitin, L. Ardatova, Iordanis Mourouzis, Costas Pantos, Alexander Kokkinos, Dennis V. Cokkinos, E. Scoditti, Marika Massaro, Maria Annunziata Carluccio, Marta Pellegrino, N. Calabriso, Amalia Gastaldelli, Carlo Storelli, Raffaele De Caterina, Daniel J. Lindner, Christin Zietsch, Heinz‐Peter Schultheiß, Carsten Tschöpe, Diedrich Westermann, B. R. Everaert, Vincent J. Nijenhuis, F. C. M. Reith, Vicky Y. Hoymans, Jean‐Pierre Timmermans, C. Vrints, Iana Simova, H. Mateev,
Fibroblast growth factors (FGFs) and their receptors play an important role during embryonic induction and patterning, as well as in modulating proliferative and hypertrophic growth in fetal and adult organs.Exogenous FGF2 (also known as basic FGF) was found to be able to induce proliferation of chick embryonic and fetal cardiac myocytes in vivo and is also important for vascular development.The aim of this study was to assess the effect of FGF2 signaling on growth of chick embryonic ventricular wall ...
Oxford University Press
Dulce Fontoura, José Oliveira‐Pinto, Marta Tavares‐Silva, Sara Leite, Francisco Vasques‐Nóvoa, Pedro Mendes‐Ferreira, André P. Lourenço, Adelino Leite‐Moreira,
Endothelin‐1 antagonists are increasingly used in the treatment of pulmonary hypertension despite the lack of knowledge of their myocardial and systemic effects. We assessed the right ventricular myocardial and systemic effects of endothelin‐1 antagonists in monocrotaline‐induced pulmonary hypertension. Male Wistar rats (180–200 g, n=57) randomly received 60 mg/kg monocrotaline or vehicle subcutaneously. Two days later, bosentan was randomly started (300 mg/kg/day) by oral route in a subgroup of monocrotaline‐ ...
Tópico(s): Cardiovascular Issues in Pregnancy
2014 - Elsevier BV | Revista Portuguesa de Cardiologia (English Edition)
João Almeida‐Coelho, Soledad Bárez‐López, Marta Borges‐Canha, Davide Carvalho, Glória Conceição, Inês Falcão‐Pires, Dulce Fontoura, Alexandre Gonçalves, Carmen Grijota-Martínez, Ana Rita Leite, Sara Leite, Adelino Leite‐Moreira, André P. Lourenço, Daniela Miranda‐Silva, Marı́a Jesús Obregón, Catarina Vale, Madalena von Hafe, João Sérgio Neves,
Abstract Introduction Low levels of triiodothyronine (T3) are common in patients with heart failure (HF). It has been proposed that the decreased levels of T3 contribute to metabolic and cardiac dysfunction in HF. We aimed to evaluate the effects of treatment with low dose and high dose of T3 in an animal model of HF with preserved ejection fraction (HFpEF). Materials and Methods We evaluated four groups: ZSF1 Lean (Lean-Ctrl, n=8), ZSF1 obese (rat model of metabolic syndrome with HFpEF, HFpEF-Ctrl, ...
Tópico(s): Cardiovascular Function and Risk Factors
2022 - Endocrine Society | Journal of the Endocrine Society
Madalena von Hafe, João Sérgio Neves, Cecília Vale, Glória Conceição, Daniela Miranda‐Silva, Sara Leite, Dulce Fontoura, Alexandra Gonçalves, João Almeida‐Coelho, Inês Falcão‐Pires, Alexandra Moreira, Adelino Leite‐Moreira,
Tópico(s): Cancer, Hypoxia, and Metabolism
2018 - Oxford University Press | European Heart Journal
Cristine Schmidt, Nádia Gonçalves, Ana Filipa Silva, Dulce Fontoura, Sara Leite, Inês Falcão‐Pires, André P. Lourenço, José Oliveira, Adelino Leite‐Moreira, Daniel Moreira‐Gonçalves,
PURPOSE:To examine, in an animal model of heart failure with preserved ejection fraction (HFpEF), whether exercise training (ExT) would be able to improve exercise capacity, diastolic function and exert an anti-inflammatory effect. METHODS: The study involved nine-week old control Wistar-Kyoto rats (WKY, n=8), ZSF1 lean rats (Lean, n=8) and ZSF1 obese (Ob n=16). At the 15th week, Ob rats were randomly divided in Ob sedentary (ObSED, n=8) and Ob exercised (ObEX, n=8; treadmill exercise training during 5 ...
Tópico(s): Cardiovascular and exercise physiology
2016 - Lippincott Williams & Wilkins | Medicine & Science in Sports & Exercise
Cristine Schmidt, Nádia Gonçalves, A. F. Silva, João Coelho, Dulce Fontoura, Sérgio Leite, Daniela Miranda‐Silva, Inês Falcão‐Pires, André P. Lourenço, José Oliveira, Adelino Leite‐Moreira, Daniel Moreira‐Gonçalves,
Introduction: Systemic inflammation and endothelial dysfunction have an important role for myocardial dysfunction and remodeling in heart failure with preserved ejection fraction (HFpEF).Microvascular endothelial inflammation leads to increased cardiomyocyte stiffness and interstitial fibrosis which induce diastolic LV dysfunction.Nonetheless, optimal treatment remains widely undefined.Purpose: To examine whether exercise training would be able to improve exercise capacity, diastolic function, left ...
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Oxford University Press | European Heart Journal
Marta Borges‐Canha, João Sérgio Neves, Clãudia Sousa-Mendes, Glória Conceição, Ana Rita Leite, von-Hafe Madalena, Catarina Vale, Dulce Fontoura, Daniela Miranda‐Silva, Sara Leite, Alexandre Gonçalves, João Almeida‐Coelho, Inês Falcão‐Pires, Davide Carvalho, Adelino Leite‐Moreira, André P. Lourenço,
Abstract Introduction Metabolic syndrome (MS) associates to obesity and non-alcoholic fatty liver disease (NAFLD). Besides its high and rising prevalence, the therapeutical options are scarce. Studies show that thyroid hormones (TH) may ameliorate hepatic function and hepatic and extra-hepatic lipid deposition. Aim To evaluate the effects of triiodothyronine (T3) treatment in high and low dose on the liver and adipose tissue of an animal model of metabolic syndrome (ZSF1 rats). Material and methods Four ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2022 - Endocrine Society | Journal of the Endocrine Society
Catarina Vale, João Sérgio Neves, Madalena von Hafe, Glória Conceição, Dulce Fontoura, Daniela Miranda‐Silva, Sara Leite, Soledad Bárez‐López, Marı́a-Jesús Obregón, Alexandra Gonçalves, João Almeida‐Coelho, André P. Lourenço, Inês Falcão‐Pires, Adelino Leite‐Moreira,
Tópico(s): Diet, Metabolism, and Disease
2018 - Oxford University Press | European Heart Journal