Giles Smith, Andrew Robson, Amanda Andrews, Carol Lewis, Geoffrey Wyborn, Robert Cole, Andrew Pierce, DJM, Neelam Verjee, Tom Dyckhoff, David Aaronovitch, Frances Gibb Legal Editor, Gary Neville, Christopher Buckmaster, Linda Tsang, Mark Frary, Zbigniew Matuszewski, Richard Hobson, Miles Goslett, Frances Blunden, Dom Joly, Philip Howard, David Pannick, David Chater, Rachel Campbell-Johnston, James Bone, Ross Appleyard, Elizabeth Judge, Gabrielle Starkey, Patrick Kidd, Matthew Hoggard, Will Pavia, Sam Marlowe, Geoff Brown, Owen Slot Sports Feature Writer, Joe Joseph, Peter Wilson, Ben Webster Transport Correspondent, Pat Gibson, Nancy Durrant, Andrew Boggis, Jane MacArtney, Stewart Tendler Crime Correspondent, Matt Hughes and Russell Kempson, Dominic Walsh, Dan Sabbagh Media Editor, Richard Nice, Debra Craine, Angela Jameson Industrial Correspondent, Dan Sabbagh, Dalya Alberge Arts Correspondent, Libby Purves, Ian D'alton, Alan Hamilton, Peter Millar, Anthony Browne Brussels Correspondent, James Delingpole, Dr Georges Ware, David Hands, Dominic Carman, Matt Dickinson Chief Football Correspondent, Bronwen Maddox Foreign Editor's Briefing, Tim Teeman, Derwent May, Angela Jameson, Russell Kempson, Nick Pearce, Edward Fennell, Simon Midgley, Oliver Kay, Philip Webster and Sam Coates, Gerard Baker, Dr John Campion, David Lister, Steve Grundy, Lisa Armstrong, Jane Wheatley, Neil O'May, Patrick Hosking Investment Editor, Stephen Burgen, Leo Lewis and Peter Klinger, Andrew Salmon, Christopher Martin-Jenkins, Frances Gibb and Andrew Norfolk, Gary Slapper, Ann Treneman, Rob Wright, Geoffrey Dean, Claire Burnell, David Rouch, Poul Nyrup Rasmussen, Gabriel Rozenberg, Dan Sabbagh and Christine Buckley, Martin Samuel, Raymond Keene, Adam Sage, Lewis Smith, Peter Riddell Political Briefing, Matt Dickinson, Matt Hughes, Steve Coomber, Dr Tanya Byron, Chris Partridge, Nigel Hawkes, Jeremy Page, Caroline Merrell, Chris Campling, Barry Packham, Patrick Hosking, Richard Owen, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Neelam Verjee and Joe Bolger, Dr Brenda Despontin, Nick Hasell, Dominic Walsh and Nick Hasell, Matt Dickinson Specialist Correspondent, David Hands Rugby Correspondent, Tom Dart, Paul Simons, Adam Fresco, Malcom I. V. Jayson, Nell Harman Tennis Correspondent, Jo Ress, Ashling O'connor, Dame Elisabeth Hoodless, Bruce Anderson, Russell Jenkins, Caitlin Moran, Alan Lee, Tim Martin, Dr Roger Sexton, Diane Hampton, Carly Chynoweth, David Charter Chief Political Correspondent, Peter Jenson, Martin Waller, Chris Ayres, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Sarah Butler, Ashling O'Connor, Stephen Cragg, Stephen Dalton, George Michael, Ben Hoyle, Henry R. Magrill, Frances Gibb, Martin Samuel Sports Writer, Richard Morrison, Alan Lee Racing Correspondent, Dominique Vuillamy, James Hider and Ali Hamdani, Olav Bjortomt, Jenny Davey, Fay Schopen, Peter Klinger, Ross Anderson, Patience Wheatcroft, Lisa Verrico, James Goldman,
... first shots at Arcelor Angela Jameson talks to Aditya Mittal about his hopes to win over both shareholders ...
2006 - Gale Group | TDA
Manish Kumar, Brijmohan Prajapati, Abhishek Singh, Shiv Kumar, Arvind Kumar, Srishti Mittal, ADITYA ADITYA,
Nanoparticles of double perovskite La2NiMnO6 (LNMO) and Yttrium (Y) doped La2NiMnO6 (LNMO) were synthesized via sol-gel route. XRD pattern of LNMO and ‘Y’ doped LNMO confirm the formation of nanocrystals and crystallize in rhombohedral crystal structure. TEM images with SAED pattern also shows the nanocrystalline nature having the particle size ranging from ~16 to 22 nm. Particle size estimated from TEM is in well agreement with XRD results. FTIR spectra and Raman spectra confirm the presence of well- ...
Tópico(s): Advanced Condensed Matter Physics
2020 - Elsevier BV | Chemical Physics
Arun Kumar Singh, Sunita Tiwari, Abhishek Gupta, Sunil M. Natu, Balraj Mittal, Aditya B. Pant,
The role of resistin in insulin sensitivity and metabolic syndrome has been controversial until now. Increased plasma/serum resistin levels are associated with metabolic syndrome and insulin resistance. The aim of this study was to investigate the relationship between serum resistin levels with markers of metabolic syndrome in males.A total of 386 male volunteers were enrolled in a case-control study. All of the enrolled volunteers were analyzed to confirm metabolic syndrome following the guidelines ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2012 - Mary Ann Liebert, Inc. | Metabolic Syndrome and Related Disorders
Suman Sundar Mohanty, Kamaraju Raghavendra, Pradeep Kumar Mittal, Aditya Prasad Dash,
Efficacy of culture filtrates of five strains of Metarhizium anisopliae isolated from insects were evaluated against Anopheles stephensi and Culex quinquefasciatus. The culture filtrates released from the strains of M. anisopliae in the YpSs and chitin broths were filtered and used for the bioassays after a growth of 7 days. Among the culture filtrates of five strains, M. anisopliae 892 was found to be more effective against both the mosquitoes. The LC50 values of culture filtrates of M. anisopliae ...
Tópico(s): Insect Resistance and Genetics
2008 - Springer Science+Business Media | Journal of Industrial Microbiology & Biotechnology
Sanjay Mittal, Aditya Kumar Raghuvanshi,
It has been observed by researchers in the past that vortex shedding behind circular cylinders can be altered, and in some cases suppressed, over a limited range of Reynolds numbers by proper placement of a second, much smaller, 'control' cylinder in the near wake of the main cylinder. Results are presented for numerical computations of some such situations. A stabilized finite element method is employed to solve the incompressible Navier–Stokes equations in the primitive variables formulation. At ...
Tópico(s): Fluid Dynamics and Turbulent Flows
2001 - Wiley | International Journal for Numerical Methods in Fluids
Himanshu Kanwat, Vivek Trikha, Samarth Mittal, Aditya Jain,
Kanwat, Himanshu MS; Trikha, Vivek MS; Mittal, Samarth MS; Jain, Aditya MS Author Information
Tópico(s): Bone and Joint Diseases
2018 - Lippincott Williams & Wilkins | Journal of Orthopaedic Trauma
Varun Sagi, Aditya Mittal, Huy Tran, Kalpna Gupta,
Pain is a major comorbidity of sickle cell disease (SCD). Patients with SCD may suffer from both acute and chronic pain. Acute pain is caused by recurrent and unpredictable episodes of vaso-occlusive crises (VOC), whereas the exact etiology of chronic pain is still unknown. Opioids are the mainstay for pain treatment, but the opioid epidemic has significantly altered access to prescription opioids and has brought concerns over their long-term use into the forefront, which have negatively impacted ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2021 - Elsevier BV | Translational research
Huy Tran, Aditya Mittal, Varun Sagi, Kathryn Luk, Aithanh Nguyen, Mihir Gupta, Julia Nguyen, Yann Lamarre, Jianxun Lei, Alonso Guedes, Kalpna Gupta,
Endothelial dysfunction underlies the pathobiology of cerebrovascular disease. Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading to blood brain barrier (BBB) dysfunction. We examined the mechanism of mast cell-induced endothelial activation via endoplasmic reticulum (ER) stress mediated P-selectin expression in a transgenic mouse model of sickle cell disease (SCD), which shows BBB dysfunction. ...
Tópico(s): Kruppel-like factors research
2019 - Frontiers Media | Frontiers in Cellular Neuroscience
Snigdha Singh, Nisha Ponnappan, Anand Verma, Aditya Mittal,
Osmotic behavior of erythrocytes is not only important clinically, but is also significant in understanding of material transport across biological membranes. It is most commonly studied through fragiligrams - plots of the degree of hemolysis as a function of extracellular osmolarity. A fundamental assumption in experimental and theoretical studies on osmolarity driven transport of water across the plasma membranes of all cells is the sigmoidal nature of their osmotic behavior. Sigmoidal data is mathematically ...
Tópico(s): Physiological and biochemical adaptations
2019 - Nature Portfolio | Scientific Reports
Aditya Mittal, Varun Sagi, Mihir Gupta, Kalpna Gupta,
Mast cells (MCs) are located in the periphery as well as the central nervous system (CNS). Known for sterile inflammation, MCs play a critical role in neuroinflammation, which is facilitated by their close proximity to nerve fibers in the periphery and meninges of the spinal cord and the brain. Multifaceted activation of MCs releasing neuropeptides, cytokines and other mediators has direct effects on the neural system as well as neurovascular interactions. Emerging studies have identified the release ...
Tópico(s): Olfactory and Sensory Function Studies
2019 - Frontiers Media | Frontiers in Cellular Neuroscience
Abstract It is known that membrane proteins are important in various secretory pathways, with a possible role of their transmembrane domains (TMDs) as sorting determinant factors. One key aspect of TMDs associated with various “checkposts” (i.e. organelles) of intracellular trafficking is their length. To explore possible linkages in organisms with varying “complexity” and differences in TMD lengths of membrane proteins associated with different organelles (such as Endoplasmic Reticulum, Golgi, Endosomes, ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2016 - Nature Portfolio | Scientific Reports
Abhishek Sharma, Satyawati Sharma, Aditya Mittal, S.N. Naik,
Tópico(s): Entomopathogenic Microorganisms in Pest Control
2016 - Springer Science+Business Media | World Journal of Microbiology and Biotechnology
Avinash Mishra, Prashant Singh Rana, Aditya Mittal, B. Jayaram,
Root-mean-square-deviation (RMSD), of computationally-derived protein structures from experimentally determined structures, is a critical index to assessing protein-structure-prediction-algorithms (PSPAs). The development of PSPAs to obtain 0Å RMSD from native structures is considered central to computational biology. However, till date it has been quite challenging to measure how far a predicted protein structure is from its native - in the absence of a known experimental/native structure. In this ...
Tópico(s): Mass Spectrometry Techniques and Applications
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Avinash Mishra, S. Srinivasa Rao, Aditya Mittal, B. Jayaram,
Specification of the three dimensional structure of a protein from its amino acid sequence, also called a "Grand Challenge" problem, has eluded a solution for over six decades. A modestly successful strategy has evolved over the last couple of decades based on development of scoring functions (e.g. mimicking free energy) that can capture native or native-like structures from an ensemble of decoys generated as plausible candidates for the native structure. A scoring function must be fast enough in ...
Tópico(s): RNA and protein synthesis mechanisms
2013 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Sakshi Kohli, Yadvir Singh, Khushbu Sharma, Aditya Mittal, Nasreen Z. Ehtesham, Seyed E. Hasnain,
Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease taking one human life every 15 s globally. The two well-characterized strains H37Rv and H37Ra, derived from the same parental strain M. tuberculosis H37, show dramatically different pathogenic phenotypes. PE/PPE gene family, comprising of 176 open reading frames and present exclusively in genus Mycobacterium, accounts for ∼10% of the M. tuberculosis genome. Our comprehensive in silico analyses of PE/PPE family ...
Tópico(s): Infectious Diseases and Tuberculosis
2012 - Oxford University Press | Nucleic Acids Research
(2011). The Newest View on Protein Folding: Stoichiometric and Spatial Unity in Structural and Functional Diversity. Journal of Biomolecular Structure and Dynamics: Vol. 28, No. 4, pp. 669-674.
Tópico(s): Hemoglobin structure and function
2011 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Mohit Naresh, Sayoni Das, Prashant Mishra, Aditya Mittal,
Abstract Elucidation of the chemical logic of life is one of the grand challenges in biology, and essential to the progress of the upcoming field of synthetic biology. Treatment of microbial cells explicitly as a “chemical” species in controlled reaction (growth) environments has allowed fascinating discoveries of elemental formulae of a few species that have guided the modern views on compositions of a living cell. Application of mass and energy balances on living cells has proved to be useful in ...
Tópico(s): Planetary Science and Exploration
2011 - Wiley | Biotechnology and Bioengineering
Abstract Folding of naturally occurring proteins has eluded a universal molecular level explanation till date. Rather, there is an abundance of diverse views on dominant factors governing protein folding. Through rigorous analyses of several thousand crystal structures, we observe that backbones of folded proteins display some remarkable invariant features. Folded proteins are characterized by spatially well-defined, distance dependent, and universal, neighborhoods of amino acids which defy any ...
Tópico(s): RNA and protein synthesis mechanisms
2011 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Neetu Kumra Taneja, Sakshi Dhingra, Aditya Mittal, Mohit Naresh, Jaya Sivaswami Tyagi,
Background Tubercle bacilli are thought to persist in a dormant state during latent tuberculosis (TB) infection. Although little is known about the host factors that induce and maintain Mycobacterium tuberculosis (M. tb) within latent lesions, O2 depletion, nutrient limitation and acidification are some of the stresses implicated in bacterial dormancy development/growth arrest. Adaptation to hypoxia and exposure to NO/CO is implemented through the DevRS/DosT two-component system which induces the ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2010 - Public Library of Science | PLoS ONE
Mohit Naresh, Vivek Hasija, Megha Sharma, Aditya Mittal,
Magnetotactic bacteria are unique prokaryotes possessing the feature of cellular organelles called magnetosomes (membrane bound 40-50 nm vesicles entrapping a magnetic nano-crystal of magnetite or greigite). The obvious energetic impact of sophisticated eukaryotic-like membrane-bound organelle assembly on a presumably simpler prokaryotic system is not addressed in literature. In this work, while presenting evidence of direct coupling of carbon source consumption to synthesis of magnetosomes, we provide ...
Tópico(s): Geology and Paleoclimatology Research
2010 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Aditya Mittal, B. Jayaram, Sandhya R. Shenoy, Tejdeep Singh Bawa,
Protein folding is at least a six decade old problem, since the times of Pauling and Anfinsen. However, rules of protein folding remain elusive till date. In this work, rigorous analyses of several thousand crystal structures of folded proteins reveal a surprisingly simple unifying principle of backbone organization in protein folding. We find that protein folding is a direct consequence of a narrow band of stoichiometric occurrences of amino-acids in primary sequences, regardless of the size and ...
Tópico(s): RNA and protein synthesis mechanisms
2010 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Varun Gupta, Krishna Saharan, Lalit Kumar, Roohi Gupta, Vikram Sahai, Aditya Mittal,
Abstract Pseudomonas fluorescens cultures produce fluorescent siderophores. By utilizing optimal conditions for maximizing siderophore production in shake flask cultures of P. fluorescens , we report successful characterization of the culture broth supernatant as a robust ferric ions biosensor. For characterizing the ferric ions biosensor, we tested the effects of pH, buffers, different ferric salts and possible interference by ferrous ions under different solution conditions. We find that the biosensor ...
Tópico(s): Microbial Fuel Cells and Bioremediation
2007 - Wiley | Biotechnology and Bioengineering
Tamar Gattegno, Aditya Mittal, Clari Valansi, Ken C. Q. Nguyen, David H. Hall, Leonid Chernomordik, Benjamin Podbilewicz,
Developmental cell fusion is found in germlines, muscles, bones, placentae, and stem cells. In Caenorhabditis elegans 300 somatic cells fuse during development. Although there is extensive information on the early intermediates of viral-induced and intracellular membrane fusion, little is known about late stages in membrane fusion. To dissect the pathway of cell fusion in C. elegans embryos, we use genetic and kinetic analyses using live-confocal and electron microscopy. We simultaneously monitor ...
Tópico(s): Evolution and Genetic Dynamics
2007 - American Society for Cell Biology | Molecular Biology of the Cell
Elena Zaitseva, Aditya Mittal, Diane E. Griffin, Leonid Chernomordik,
Viral fusion proteins of classes I and II differ radically in their initial structures but refold toward similar conformations upon activation. Do fusion pathways mediated by alphavirus E1 and influenza virus hemagglutinin (HA) that exemplify classes II and I differ to reflect the difference in their initial conformations, or concur to reflect the similarity in the final conformations? Here, we dissected the pathway of low pH-triggered E1-mediated cell-cell fusion by reducing the numbers of activated ...
Tópico(s): Respiratory viral infections research
2005 - Rockefeller University Press | The Journal of Cell Biology
Thuy Tran, Tracy L. Gales, Beverly E. Maleeff, Tanya Aldinger, Joseph W. Polli, Andrew D. Ayrton, Harma Ellens, Joe Bentz, Aditya Mittal,
Knowledge of the passive permeability coefficient for new drugs is useful for estimating the fraction absorbed across the gastrointestinal tract. The commonly used approximate formula for the passive permeability coefficient is based on the initial rate of permeation across cell monolayers, requires measurement during the linear phase of permeation, and is not applicable when there is significant back flux of compound or mass balance problem. To develop a rigorous equation that can be used at any ...
Tópico(s): HIV/AIDS drug development and treatment
2004 - Elsevier BV | Journal of Pharmaceutical Sciences
Thuy Tran, Aditya Mittal, Tanya Aldinger, Joseph W. Polli, Andrew D. Ayrton, Harma Ellens, Joe Bentz,
Tópico(s): HIV/AIDS drug development and treatment
2004 - Elsevier BV | Biophysical Journal
Eugenia Leikina, Aditya Mittal, Myoung‐Soon Cho, Kamran Melikov, Michael M. Kozlov, Leonid Chernomordik,
Current models for membrane fusion in diverse biological processes are focused on the local action of fusion proteins present in the contact zone where the proteins anchored in one membrane might interact directly with the other membrane. Are the fusion proteins outside of the contact zone just bystanders? Here we assess the role of these "outsider" proteins in influenza virus hemagglutinin-mediated fusion between red blood cells and either hemagglutinin-expressing cells or viral particles. To selectively ...
Tópico(s): Cellular transport and secretion
2004 - Elsevier BV | Journal of Biological Chemistry
Aditya Mittal, Eugenia Leikina, Leonid Chernomordik, Joe Bentz,
Membrane fusion mediated by influenza virus hemagglutinin (HA) yields different phenotypes depending on the surface density of activated HAs. A key question is whether different phenotypes arise from different fusion machines or whether different numbers of identical fusion machines yield different probabilistic outcomes. If fusion were simply a less probable event than hemifusion, requiring a larger number of identical fusion machines to occur first, then two predictions can be made. First, fusion ...
Tópico(s): Receptor Mechanisms and Signaling
2003 - Elsevier BV | Biophysical Journal
The mechanism of influenza hemagglutinin (HA) mediated membrane fusion has been intensively studied for over 20 years after the bromelain-released ectodomain of HA at neutral pH was first crystallized. Nearly 10 years ago, the low-pH-induced "spring coiled" conformational change of HA was predicted from peptide chemistry and confirmed by crystallography. Other work has yielded a wealth of knowledge on the observed changes in HA fusion/hemifusion phenotypes as a function of site-specific mutations ...
Tópico(s): Lipid Membrane Structure and Behavior
2003 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes
Aditya Mittal, Tong Shangguan, Joe Bentz,
The data for the pH dependence of lipid mixing between influenza virus (A/PR/8/34 strain) and fluorescently labeled liposomes containing gangliosides has been analyzed using a comprehensive mass action kinetic model for hemaglutinin (HA)-mediated fusion. Quantitative results obtained about the architecture of HA-mediated membrane fusion site from this analysis are in agreement with the previously reported results from analyses of data for HA-expressing cells fusing with various target membranes. Of ...
Tópico(s): Protein Structure and Dynamics
2002 - Elsevier BV | Biophysical Journal