Wenyan Xie, Jacob Adolf, Matthias F. Melzig,
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its ...
Tópico(s): Heat shock proteins research
2017 - Public Library of Science | PLoS ONE
Christopher R. Strauss, Bevan Wilson, A. Rapp, Matthias Guentert, Patrick J. Williams,
... grape wines and brandiesChristopher R. Strauss, Bevan Wilson, Adolf Rapp, Matthias Guentert, and Patrick J. WilliamsCite this: J. Agric. ...
Tópico(s): Plant biochemistry and biosynthesis
1985 - American Chemical Society | Journal of Agricultural and Food Chemistry
Josa M. Frischer, Astrid Fraller, Ammar Mallouhi, Ursula Vogl, Franziska Baier, Adolf Ertl, Matthias Preusser, Engelbert Knosp, K. Kitz, Brigitte Gatterbauer,
The study aim was to evaluate the utility of 2-fraction, dose-staged Gamma Knife radiosurgery (GKRS) in patients with large, high-risk brain metastases (BMs). A total of 63 large BMs in eloquent areas in 61 patients were treated with GKRS in 2 reduced doses. Treatment planning was conducted on the 50% isodose line and included the whole tumor volume as seen on T1 contrast-enhanced and T2-weighted magnetic resonance imaging sections. The median margin and central dose were 12 Gy and 24 Gy, respectively, ...
Tópico(s): Meningioma and schwannoma management
2016 - Elsevier BV | World Neurosurgery
Adolf Nahrstedt, Matthias Lechtenberg, Anita Brinker, David S. Seigler, Robert Hegnauer,
The cyanogenic glucosides dhurrin [2S-β-d-glucopyranosyloxy-2-(4-hydroxy)-phenylacetonitrile] and taxiphyllin [2R-β-d-glucopyranosyloxy-2-(4-hydroxy) -phenylacetonitrile] have been isolated as the only cyanogenic glycosides from all parts of Suckleya suckleyana (dhurrin) and a herbarium specimen of Girgensohnia oppositiflora (taxiphyllin) of the Chenopodiaceae. The leaves of S. suckleyana contain the highest concentration of dhurrin followed by fruits, stems and roots.
Tópico(s): Botany, Ecology, and Taxonomy Studies
1993 - Elsevier BV | Phytochemistry
Agnes Neumayr, André Gnirke, Joerg C. Schaeuble, Michael T. Ganter, H. J. Sparr, Adolf Zoll, Adolf Schinnerl, Matthias Nuebling, Thomas Heidegger, Michael Baubin,
There is only limited information on patient satisfaction with emergency medical services (EMS). The aim of this multicentre survey was to evaluate patient satisfaction in five out-of-hospital physician-based EMS in Austria and Switzerland.The psychometrically tested and standardized questionnaire 'patient satisfaction in out-of-hospital emergency care' was used for this survey. The recruitment of the patients was carried out on the basis of inclusion and exclusion criteria. All questionnaires were ...
Tópico(s): Medical Malpractice and Liability Issues
2015 - Lippincott Williams & Wilkins | European Journal of Emergency Medicine
Veronika Butterweck, Hartmut Derendorf, Wilhelm Gaus, Adolf Nahrstedt, Volkmar Schulz, Matthias Unger,
Pharmacokinetic interactions often occur as a result of activity changes of drug-metabolizing and transporting proteins, especially cytochrome P450 (CYP) isoenzymes and P-glycoprotein (P-gp). The activity of these enzymes and drug transporters can be enhanced or inhibited by synthetic drugs as well as by natural products. Since the number of herb-drug interactions has increased in recent years, systematic in vitro screenings and more clinical studies to identify such interactions were proposed for ...
Tópico(s): Pharmacology and Obesity Treatment
2004 - Thieme Medical Publishers (Germany) | Planta Medica
Jochen Ellermann, Adolf Veit Und Matthias Moll,
[HN(CH2CH2Cl)2CH2CH(CH3)Cl]Cl (V). [HN{CH2CH(CH3)Cl}3]Cl (VII) and the 1,3,5-trithiacyclohexane derivative (CHS)3(CH2CH2Cl)3 (IX) react with NaAs(C6H5)2 in liquid ammonia to give N[CH2CH2As(C6H5)2]2CH2CH(CH3)As(C6H5)2 (VI). N[CH2CH(CH3)As(C6H5)2]3 (VIII) and (CHS)3[CH2CH2As(C6H5)2]3 (X). Treatment of VI with HI results, under elimination of benzene, almost quantitatively in the formation of [HN(CH2CH2AsI2)2CH2CH(CH2)AsI2]I (XI), which is recrystallized from THF as [HN(CH2CH2AsI2)2CH2CH(CH3)AsI2]I · THF (1/1) (XIa). ...
Tópico(s): Crystal structures of chemical compounds
1986 - Elsevier BV | Journal of Organometallic Chemistry
Kostadinka Bizheva, Angelika Unterhuber, Boris Hermann, Boris Považay, Harald Sattmann, Adolf F. Fercher, Wolfgang Drexler, Matthias Preusser, Herbert Budka, A. Stingl, T. Le,
The ability of ultra-high-resolution optical coherence tomography (UHR OCT) to discriminate between healthy and pathological human brain tissue is examined by imaging ex vivo tissue morphology of various brain biopsies. Micrometer-scale OCT resolution (0.9×2 µm, axial×lateral) is achieved in biological tissue by interfacing a state-of-the-art Ti:Al2O3 laser (c=800 nm, =260 nm, and Pout=120 mW exfiber) to a free-space OCT system utilizing dynamic focusing. UHR OCT images are acquired from both healthy ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2005 - SPIE | Journal of Biomedical Optics
Kerstin Boje, Matthias Lechtenberg, Adolf Nahrstedt,
Ten compounds, harpagoside (1), 8-p-coumaroylharpagide (2), 8-feruloylharpagide (3), 8-cinnamoylmyoporoside (4), pagoside (5), acteoside (6), isoacteoside (7), 6′-O-acetylacteoside (8), cinnamic acid (9) and caffeic acid (10) were isolated from the storage roots of Harpagophytum procumbens, Pedaliaceae. Compounds 1, 2, 6, 7 and 9 are known for H. procumbens; 3 and 10 were isolated the first time from H. procumbens; compounds 4, 5 and 8 are new natural products. Their structures were elucidated using spectroscopic ...
Tópico(s): Phytochemistry and Bioactive Compounds
2003 - Thieme Medical Publishers (Germany) | Planta Medica
Katrin Althoff, Matthias Mundt, Adolf Eisentraeger, Wolfgang Dott, Juliane Hollender,
Groundwater samples from six wells of a former gas plant site were characterised using chemical, microbial and ecotoxicological methods. Degradation studies were performed in batch-culture under aerobic conditions with the groundwater samples containing their autochthonous microflora and original contaminant mixture. The highest O2-consumption (3 mmol 100 ml−1), combined with BTEX (8.3 mg l−1) and naphthalene (171.3 mg l−1) degradation, as well as formation of organic acids was found after N- and P- ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2001 - Elsevier BV | Water Research
Matthias Lechtenberg, Adolf Nahrsted, Frank R. Fronczek,
Tópico(s): Botanical Studies and Applications
1996 - Elsevier BV | Phytochemistry
Matthias Lechtenberg, Adolf Nahrstedt, Victor Wray, Frank R. Fronczek,
Three nitrile glucosides have been isolated from a methanolic extract of the leaves of Osmaronia cerasiformis (Torr. & Gray) Greene (Rosaceae, Prunoideae). One is the known sutherlandin (Z-4-beta-D-glucopyranosyloxy-3-hydroxymethylbut-2-ene nitrile); the second is Z-4-beta-glucopyranosyloxy-3-methylbut-2-ene nitrile, which has recently been characterized but whose stereochemistry was not previously determined; the Z-isomer identified here was named osmaronin. The third is the new 4-beta-D-glucopyranosyloxy- ...
Tópico(s): Phytochemical Studies and Bioactivities
1994 - Elsevier BV | Phytochemistry
B Löser, Sven O. Kruse, Matthias F. Melzig, Adolf Nahrstedt,
Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F isolated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited the activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner. An IC50 of 93 μmol/L was determined for caffeic acid and 0.23 μmol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 of 2.2 μmol/L, cimicifugic acid B with 11.4 μmol/L, and cimicifugic acid F with 18 μmol/L. Cimicifugic acid E was only a very weak inhibitor.
Tópico(s): Marine Biology and Environmental Chemistry
2000 - Thieme Medical Publishers (Germany) | Planta Medica
Anne Grotevendt, Henri Wallaschofski, Martín Reincke, Christian Adolf, Marcus Quinkler, Matthias Nauck, Wolfgang Hoffmann, Rainer Rettig, Anke Hannemann,
Tópico(s): Electrolyte and hormonal disorders
2017 - Springer Science+Business Media | Endocrine
Lucian Beer, Rudolf Seemann, Robin Ristl, Adolf Ellinger, Mohammad Mahdi Kasiri, Andreas Mitterbauer, Matthias Zimmermann, Christian Gabriel, Mariann Gyöngyösi, Walter Klepetko, Michael Mildner, Hendrik Jan Ankersmit,
High dose ionizing radiation (IR) induces potent toxic cell effects mediated by either direct DNA damage or the production of reactive oxygen species (ROS). IR-induced modulations in multiple biological processes have been proposed to be partly regulated by radiosensitive microRNA (miRNA). In order to gain new insights into the role of miRNAs in the regulation of biological processes after IR, we have investigated changes in mRNA and miRNA expression after high dose IR. IR induced changes in the mRNA ...
Tópico(s): Kruppel-like factors research
2014 - BioMed Central | BMC Genomics
Martin Steegmaier, Matthias Hoffmann, Anke Baum, Péter Lénárt, Mark Petronczki, Martin Krššák, Ulrich Gürtler, Pilar Garin‐Chesa, Simone Lieb, Jens Quant, Matthias Grauert, Günther R. Adolf, Norbert Kraut, Jan‐Michael Peters, Wolfgang J. Rettig,
Fine-mapping of the cell-division cycle, notably the identification of mitotic kinase signaling pathways, provides novel opportunities for cancer-drug discovery. As a key regulator of multiple steps during mitotic progression across eukaryotic species, the serine/threonine-specific Polo-like kinase 1 (Plk1) is highly expressed in malignant cells and serves as a negative prognostic marker in specific human cancer types [1Barr F.A. Sillje H.H. Nigg E.A. Polo-like kinases and the orchestration of cell ...
Tópico(s): DNA Repair Mechanisms
2007 - Elsevier BV | Current Biology
... Dr. Luc Pieters (Editor-in-Chief), Prof. Dr. Adolf Nahrstedt (Senior Editor) and Prof. Dr. Matthias Hamburger (Review Editor) was organized at the 2013 ...
Tópico(s): Phytochemistry and Bioactive Compounds
2014 - Thieme Medical Publishers (Germany) | Planta Medica
Lucian Beer, Matthias Zimmermann, Andreas Mitterbauer, Adolf Ellinger, Флориан Грубер, Marie‐Sophie Narzt, Maria Zellner, Mariann Gyöngyösi, Sibylle Madlener, Elisabeth Simader, Christian Gabriel, Michael Mildner, Hendrik Jan Ankersmit,
Abstract We previously showed that, when peripheral blood mononuclear cells (PBMCs) were stressed with ionizing radiation, they released paracrine factors that showed regenerative capacity in vitro and in vivo . This study aimed to characterize the secretome of PBMCs and to investigate its biologically active components in vitro and vivo . Bioinformatics analysis revealed that irradiated PBMCs differentially expressed genes that encoded secreted proteins. These genes were primarily involved in (a) pro- ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2015 - Nature Portfolio | Scientific Reports
Matthias Lechtenberg, B Quandt, Adolf Nahrstedt,
Abstract The three major curcuminoids, curcumin, demethoxycurcumin and bis‐demethoxycurcumin, from Curcuma domestica Val. ( Curcuma longa L.) and Curcuma xanthorrhiza Roxb. (Zingiberaceae) were fully separated and quantified in less than 5 min using a capillary zone electrophoresis method with standard fused‐silica capillaries and photodiode array detection. An electrolyte solution of 20 m m phosphate, 50 m m sodium hydroxide and 14 m m β ‐cyclodextrin was found to be appropriate. Quantification was performed ...
Tópico(s): Essential Oils and Antimicrobial Activity
2004 - Wiley | Phytochemical Analysis
Christoph K. Hitzenberger, Matthias Danner, Wolfgang Drexler, Adolf F. Fercher,
Abstract In recent years, superluminescent diodes (SLDs) have gained increasing importance as light sources for partial coherence interferometry and optical coherence tomography. The requirements of SLDs are high spatial coherence, low temporal coherence, and, for some applications, high power. Since there might be a trade-off between these properties we built an instrument for measuring the spatial coherence of SLDs. This instrument consists of a hybrid bulk optic-fibre optic Mach-Zehnder interferometer. ...
Tópico(s): Advanced Fiber Optic Sensors
1999 - Taylor & Francis | Journal of Modern Optics
Matthias Coen, R. Engel, Adolf Nahrstedt,
The volatile substances obtained after enzymatic hydrolysis of purified polar extracts from the aerial parts of the two subspecies of Cedronella canariensis were shown to be, among others, benzyl alcohol (29.4%), chavicol (11.6%), cis-3-hexenol (9.3%), 2-phenylethanol (8.6%), cis-pinocarveol (5.1%), myrtenol (2.2%), 1-phenylethanol (2.0%, tentatively), 1-octen-3-ol (1.8%), 1-hexanol (1.1%) for ssp. canariensis and chavicol (85.1%), benzyl alcohol (2.5%), cis-3-hexenol (2.5%), 1-octen-3-ol (2.3%); 1-hexanol (0. ...
Tópico(s): Phytochemistry and Biological Activities
1995 - Elsevier BV | Phytochemistry
Hermann Irngartinger, Matthias Nixdorf, Norbert Riegler, Adolf Krebs, Horst Kimling, Jürgen Pocklington, Günther Maier, K.‐D. MALSCH, Klaus‐Albert Schneider,
Die Molekülstruktur der Cyclobutadien-Derivate 1–3 wird mit Röntgenbeugung bestimmt. Das Derivat 2 kristallisiert in zwei verschiedenen Modifikationen mit unterschiedlichen molekularen Konformationen. Die Form 2a enthält sesselförmige Siebenringe wie 1, die Form 2b twistförmige Siebenringe. Die Vierringe von 1 und 2a sind planar, von 2b und 3 gefaltet (176.9° und 170.2°). Sie sind deutlich nicht-quadratisch. Ihre Bindungslängen sind für 1 und 2 stark alternierend: 1.34 und 1.59–1.60 Å. Eine Tieftemperaturmessung ( ...
Tópico(s): Synthesis and characterization of novel inorganic/organometallic compounds
1988 - Wiley | Chemische Berichte
Anke Witt, Ivona Mateska, Alessandra Palladini, Anupam Sinha, Michele Wölk, Akiko Harauma, Nicole Bechmann, Christina Pamporaki, Andreas Dahl, Michael Rothe, Irakli Kopaliani, Christian Adolf, Anna Riester, Ben Wielockx, Stefan R. Bornstein, Matthias Kroiß, Mirko Peitzsch, Toru Moriguchi, Maria Fedorova, Michał Grzybek, Triantafyllos Chavakis, Peter Mirtschink, Vasileia Ismini Alexaki,
Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition of the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis. Consistently, the adrenocortical mitochondria of Fads2 −/− ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2023 - American Association for the Advancement of Science | Science Advances
Eberhard Merk, Ludwig Biewer, Eckart Henning,
... Wappen. Handbuch der Heraldik. Als „Wappenfibel“ begründet von Adolf Matthias Hildebrandt, zuletzt weitergeführt von Jürgen Arndt, hg. vom ...
Tópico(s): Digitalization, Law, and Regulation
2022 - Kohlhammer Verlag | Zeitschrift für Württembergische Landesgeschichte
Christoph Weise, Achim Schrot, Leonie T. D. Wuerger, Jacob Adolf, Roger Gilabert‐Oriol, Simko Sama, Matthias F. Melzig, Alexander Weng,
Abstract Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part true. However Agrostemma githago L. is also a producer of ribosome-inactivating proteins (RIPs). RIPs are N -glycosylases that inactivate the ribosomal RNA, a process leading to ...
Tópico(s): RNA and protein synthesis mechanisms
2020 - Nature Portfolio | Scientific Reports
Matthias Schneider, Dominik Lücke, Thomas Adolf,
In smart factories, maintenance is still an important aspect to safeguard the performance of their production. Especially in case of failures of machine components diagnosis is a time-consuming task. This paper presents an approach for a cyber-physical failure management system, which uses information from machines such as programmable logic controller or sensor data and IT systems to support the diagnosis and repairing process. Key element is a model combining the different information sources ...
Tópico(s): Physical Unclonable Functions (PUFs) and Hardware Security
2019 - Elsevier BV | Procedia CIRP
Malte Johannes Hannich, Henri Wallaschofski, Matthias Nauck, Martín Reincke, Christian Adolf, Henry Völzke, Rainer Rettig, Anke Hannemann,
Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2018 - Hindawi Publishing Corporation | International Journal of Endocrinology
Monika Hungeling, Matthias Lechtenberg, Frank R. Fronczek, Adolf Nahrstedt,
Seven cyanopyridone derivatives and one corresponding seco compound have been isolated from a methanolic extract of the inflorescences and leaves of Acalypha indica L. (Euphorbiaceae). The absolute configuration of the main cyanogenic glucoside acalyphin, (-)-(5R,6S)-5-cyano-5-beta-d-glucopyranosyloxy-6-hydroxy-4-methoxy-1-methyl-2(5,6-dihydro)-pyridone, was deduced from an X-ray crystallographic study. In addition, the 6R-epimer of acalyphin, epiacalyphin, and the corresponding pair of N-demethyl derivatives ...
Tópico(s): Chemical synthesis and alkaloids
2009 - Elsevier BV | Phytochemistry
Cornelia Haug, Wolfgang Köenig, Martin Hoeher, Matthias Kochs, Vinzenz Hombach, Adolf Gruenert, Hans H. Osterhues,
Recent studies have suggested that the plasma concentrations of endothelin-1, a potent vasoconstrictive peptide, are increased in patients with congestive heart failure. This study aimed to evaluate a new direct ELISA for big endothelin-1 (the precursor of endothelin-1), in comparison with a big endothelin-1 ELISA using plasma sample extraction, and to investigate whether plasma big endothelin-1 concentrations correlate with indicators of left ventricular function. The direct ELISA yielded significantly ( ...
Tópico(s): Cardiovascular and exercise physiology
1998 - American Association for Clinical Chemistry | Clinical Chemistry
... Peter B. Becker Corresponding Author Peter B. Becker Adolf-Butenandt-Institut, Molekularbiologie, Schillerstrasse 44, D-80336 München, Germany Search for more papers by this author Author Information Anton Eberharter1, Simona Ferrari2, Gernot Längst1, Tobias Straub1, Axel Imhof1, Patrick Varga-Weisz3, Matthias Wilm4 and Peter B. Becker 1 1Adolf-Butenandt- ...
Tópico(s): Protein Degradation and Inhibitors
2001 - Springer Nature | The EMBO Journal