Federica Barbieri, Alessandra Pattarozzi, Monica Gatti, Cinzia Aiello, Ana Quintero, Gianluigi Lunardi, Adriana Bajetto, Angelo Ferrari, Michael D. Culler, Tullio Florio,
Somatostatin receptors (SSTR1–5) mediate antiproliferative effects. In C6 rat glioma cells, somatostatin is cytostatic in vitro via phosphotyrosine phosphatase-dependent inhibition of ERK1/2 activity mediated by SSTR1, -2, and -5. Here we analyzed the effects of SSTR activation on C6 glioma growth in vivo and the intracellular mechanisms involved, comparing somatostatin effects with selective agonists for SSTR1, -2, and -5 (BIM-23745, BIM-23120, BIM-23206) or receptor biselective compounds (SSTR1 and -2, ...
Tópico(s): Pituitary Gland Disorders and Treatments
2009 - American Physiological Society | AJP Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Desireé S. da Silva, Miriam Dantzger, Michelle Alexandrino de Assis, Jéssica Carolina Medina Gallardo, Gleidson Silva Teixeira, Sílvia K. Missawa, Romênia R. Domingues, Marcelo Falsarella Carazzolle, Inês Lunardi, Adriana Franco Paes Leme, Gonçalo Amarante Guimarães Pereira, Lucas S. Parreiras,
The fungus Trichoderma reesei is employed in the production of most enzyme cocktails used by the lignocellulosic biofuels industry today. Despite significant improvements, the cost of the required enzyme preparations remains high, representing a major obstacle for the industrial production of these alternative fuels. In this study, a new Trichoderma erinaceum strain was isolated from decaying sugarcane straw. The enzyme cocktail secreted by the new isolate during growth in pretreated sugarcane straw- ...
Tópico(s): Enzyme Production and Characterization
2019 - Elsevier BV | Fungal Biology
... subjects with COPDThiago Fernandes Pinto, Rafaella Fagundes Xavier, Adriana Claudia Lunardi, Cibele Cristine Berto Marques da Silva, Henrique Takachi ...
Tópico(s): Non-Invasive Vital Sign Monitoring
1967 - American Physiological Society | Journal of Applied Physiology
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Cibele Cristine Berto Marques da Silva, Felipe Augusto Rodrigues Mendes, Amélia Pasqual Marques, Rafaël Stelmach, Celso Ricardo Fernandes Carvalho,
Background. The mechanical alterations related to the overload of respiratory muscles observed in adults with persistent asthma might lead to the development of chronic alterations in posture, musculoskeletal dysfunction and pain; however, these changes remain poorly understood. Objective. This study aimed to assess postural alignment, muscle shortening and chronic pain in adults with persistent asthma. Methods. This cross-sectional and controlled study enrolled 30 patients with mild (n = 17) and severe ( ...
Tópico(s): Myofascial pain diagnosis and treatment
2010 - Taylor & Francis | Journal of Asthma
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Camila Souza Miranda, KAROLINE M. SILVA, Ivan Cecconello, Celso Ricardo Fernandes Carvalho,
Malnutrition is prevalent in hospitalized patients and causes systemic damage including effects on the respiratory and immune systems, as well as predisposing to infection and increasing postoperative complications and mortality. This study aimed to assess the impact of malnutrition on the rate of postoperative pulmonary complications, respiratory muscle strength and chest wall expansion in patients undergoing elective upper abdominal surgery.Seventy-five consecutive candidates for upper abdominal ...
Tópico(s): Frailty in Older Adults
2011 - Wiley | Respirology
Produção Nacional
Revisado por pares
Celso Ricardo Fernandes Carvalho, Denise Paisani, Adriana Cláudia Lunardi,
OBJECTIVE: To conduct a systematic review to evaluate the evidence of the use of incentive spirometry (IS) for the prevention of postoperative pulmonary complications and for the recovery of pulmonary function in patients undergoing abdominal, cardiac and thoracic surgeries. METHODS: Searches were performed in the following databases: Medline, Embase, Web of Science, PEDro and Scopus to select randomized controlled trials which the IS was used in pre- and/or post-operative in order to prevent postoperative ...
Tópico(s): Respiratory Support and Mechanisms
2011 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Cibele C. B. M. Silva, Adriana Cláudia Lunardi, Felipe Augusto Rodrigues Mendes, Flavia F. P. Souza, Celso Ricardo Fernandes Carvalho,
The Objective Structured Clinical Evaluation (OSCE) has been considered a reliable method for the evaluation of students' clinical skills in health sciences, but it has been rarely applied in the teaching of physical therapy.To assess the use of the OSCE as a tool to evaluate the abilities of undergraduate chest physical therapy students and to verify the internal consistency of the OSCE exam.Forty-seven students were evaluated using two types of exams: the traditional exam and the OSCE. Independent ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2011 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Ivan Cecconello, Celso Ricardo Fernandes Carvalho,
BACKGROUND: Esophagectomy presents the highest rate of postoperative pulmonary complications among all types of upper abdominal surgery. The benefits of chest physical therapy in patients undergoing upper abdominal surgery have been shown by many studies; however, its specific effect in patients receiving esophagectomy has been seldom investigated. OBJECTIVES: This study aimed to compare the frequency of respiratory complications in patients undergoing esophagectomy receiving chest physical therapy ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2011 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Denise Paisani, Julio F. Fiore, Adriana Cláudia Lunardi, DANIELA B.B. COLLUCI, Ilka Lopes Santoro, Celso Ricardo Fernandes Carvalho, Luciana Dias Chiavegato, Sônia Maria Faresin,
ABSTRACT Background and objective: Field exercise tests have been increasingly used for pulmonary risk assessment. The six‐min walking distance (6MWD) is a field test commonly employed in clinical practice; however, there is limited evidence supporting its use as a risk assessment method in abdominal surgery. The aim was to assess if the 6MWD can predict the development of post‐operative pulmonary complications (PPCs) in patients having upper abdominal surgery (UAS). Methods: This prospective cohort ...
Tópico(s): Delphi Technique in Research
2012 - Wiley | Respirology
Produção Nacional
Revisado por pares
Denise de Moraes Paisani, Adriana Cláudia Lunardi, Cibele Cristine Berto Marques da Silva, Desidério Cano Porras, Clarice Tanaka, Celso Ricardo Fernandes Carvalho,
Incentive spirometers are widely used in clinical practice and classified as flow-oriented (FIS) and volume-oriented (VIS). Until recently the respiratory inductive plethysmography used to evaluate the effects of incentive spirometry on chest wall mechanics presented limitations, which may explain why the impact of VIS and FIS remains poorly known.To compare the effects of VIS and FIS on thoracoabdominal mechanics and respiratory muscle activity in healthy volunteers.This cross-sectional trial assessed ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2012 - American Association for Respiratory Care | Respiratory Care
Produção Nacional
Revisado por pares
Érika Yukie Ishigaki, Lidiane G. Ramos, Elisa S. Carvalho, Adriana Cláudia Lunardi,
Background: Falls are a geriatric syndrome that is considered a significant public health problem in terms of morbidity and mortality because they lead to a decline in functional capacity and an impaired quality of life in the elderly. Lower limb muscle strengthening seems to be an effective intervention for preventing falls; however, there is no consensus regarding the best method for increasing lower limb muscle strength. Objectives: To analyze the effectiveness of lower limb muscle strengthening ...
Tópico(s): Stroke Rehabilitation and Recovery
2014 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Desidério Cano Porras, Renata CC Barbosa, Denise Paisani, Cibele CB Marques da Silva, Clarice Tanaka, Celso Ricardo Fernandes Carvalho,
BACKGROUND: Aging causes physiological and functional changes that impair pulmonary function. Incentive spirometry is widely used for lung expansion, but the effects of volume-oriented incentive spirometry (VIS) versus flow-oriented incentive spirometry (FIS) on chest wall volumes, inspiratory muscle activity, and thoracoabdominal synchrony in the elderly are poorly understood. We compared VIS and FIS in elderly subjects and healthy adult subjects. METHODS: Sixteen elderly subjects (9 women, mean ± SD age 70.6 ± ...
Tópico(s): Dysphagia Assessment and Management
2013 - American Association for Respiratory Care | Respiratory Care
Produção Nacional
Revisado por pares
Felipe Augusto Rodrigues Mendes, Adriana Cláudia Lunardi, Ronaldo Aparecido da Silva, Alberto Cukier, Rafaël Stelmach, Mílton A. Martins, Celso Ricardo Fernandes Carvalho,
Background. The symptoms of asthma impair health-related quality of life (HRQoL), increase anxiety and depression and may keep subjects from engaging in physical exercise. Physical inactivity has been related to poor asthma outcomes; however, the association between physical fitness and psychosocial disorders remains poorly understood. Objective. To verify the association between aerobic capacity, HRQoL, and psychological distress in adults with moderate or severe persistent asthma who were clinically ...
Tópico(s): Behavioral Health and Interventions
2013 - Taylor & Francis | Journal of Asthma
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Denise de Moraes Paisani, Clarice Tanaka, Celso Ricardo Fernandes Carvalho,
To evaluate the effect of laparoscopic surgery on pulmonary volume distributions and inspiratory muscles activity. Respiratory consequences associated with postoperative pain were also evaluated. This study enrolled 20 patients without lung disease performed spirometry and chest wall kinematic analyses (i.e., chest wall, upper and lower ribcage and abdominal volumes), and measured the activity of inspiratory muscular before and 2 days after laparoscopic surgery. Pain was also assessed. After laparoscopy, ...
Tópico(s): Obstructive Sleep Apnea Research
2013 - Elsevier BV | Respiratory Physiology & Neurobiology
Produção Nacional
Revisado por pares
Adriana Cláudia Lunardi, Denise Paisani, Cibele C.B. Marques da Silva, Desidério Cano Porras, Clarice Tanaka, Celso Ricardo Fernandes Carvalho,
OBJECTIVE Lung expansion techniques (LETs) are widely used to prevent postoperative pulmonary complications (PPCs). However, the effects of each of these techniques on thoracoabdominal mechanics and PPC incidence after abdominal surgery remain unclear. The objective of this study was to compare the effects of LET on pulmonary volumes, respiratory muscle activation, and PPC incidence after major, elective upper abdominal surgery. METHODS This randomized controlled trial enrolled 137 patients who were ...
Tópico(s): Pleural and Pulmonary Diseases
2015 - Elsevier BV | CHEST Journal
Produção Nacional
Revisado por pares
Erickson Borges-Santos, Juliano Wada, Cibele Marques da Silva, Ronaldo Aparecido da Silva, Rafaël Stelmach, Celso Ricardo Fernandes Carvalho, Adriana Cláudia Lunardi,
To investigate the relationship between the presence of symptoms of anxiety or depression with breathing pattern and thoracoabdominal mechanics at rest and during exercise in COPD. Cross-sectional study enrolled 54 patients with COPD ranked according to Hospital Anxiety and Depression Scale (HAD) score and compared to dyspnea, clinical control, hypercapnia, breathing pattern and thoracoabdominal mechanics at rest and during exercise. Seventeen patients with COPD had no symptoms, 12 had anxiety symptoms, ...
Tópico(s): Obstructive Sleep Apnea Research
2015 - Elsevier BV | Respiratory Physiology & Neurobiology
Produção Nacional
Revisado por pares
Juliano Wada, Erickson Borges-Santos, Desidério Cano Porras, Denise Paisani, Alberto Cukier, Adriana Cláudia Lunardi, Celso Ricardo Fernandes Carvalho,
Background: Patients with COPD present a major recruitment of the inspiratory muscles, predisposing to chest incoordination, increasing the degree of dyspnea and impairing their exercise capacity. Stretching techniques could decrease the respiratory muscle activity and improve their contractile capacity; however, the systemic effects of stretching remain unknown. Objective: The aim of this study was to evaluate the effects of aerobic training combined with respiratory muscle stretching on functional ...
Tópico(s): Medical research and treatments
2016 - Dove Medical Press | International Journal of COPD
Produção Nacional
Revisado por pares
Mayra Caleffi Pereira, Desidério Cano Porras, Adriana Cláudia Lunardi, Cibele Cristine Berto Marques da Silva, Renata Cléia Claudino Barbosa, Letícia Zumpano Cardenas, Renata Pletsch, Jeferson George Ferreira, Isac de Castro, Celso Ricardo Fernandes Carvalho, Pedro Caruso, Carlos Roberto Ribeiro de Carvalho, André Luís Pereira de Albuquerque,
Thoracoabdominal asynchrony is the nonparallel motion of the ribcage and abdomen. It is estimated by using respiratory inductive plethysmography and, recently, using optoelectronic plethysmography; however the agreement of measurements between these 2 techniques is unknown. Therefore, the present study compared respiratory inductive plethysmography with optoelectronic plethysmography for measuring thoracoabdominal asynchrony to see if the measurements were similar or different.27 individuals (9 healthy ...
Tópico(s): Asthma and respiratory diseases
2017 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Desidério Cano Porras, Adriana Cláudia Lunardi, Cibele C.B. Marques da Silva, Denise Paisani, Rafaël Stelmach, Henrique Takachi Moriya, Celso Ricardo Fernandes Carvalho,
Determining the presence of thoracoabdominal asynchrony in chronic obstructive pulmonary disease (COPD) patients is clinically relevant, but there is no consensus on the optimal parameters for performing this analysis. We assessed 22 COPD patients (FEV1 40 ± 10% predicted) and 13 healthy controls during rest and exercise with optoelectronic plethysmography (70% maximum workload) on a cycle ergometer. Thoracoabdominal asynchrony was calculated by using phase angle and phase shift parameters following ...
Tópico(s): Neuroscience of respiration and sleep
2017 - American Physiological Society | Journal of Applied Physiology
Produção Nacional
Revisado por pares
Daniel Souza, Fernando Wegner, Lucíola da Cunha Menezes Costa, Luciana Dias Chiavegato, Adriana Cláudia Lunardi,
To test the measurement properties (reproducibility, internal consistency, ceiling and floor effects, and construct validity) of the Human Activity Profile (HAP) questionnaire in hospitalized patients. This measurement properties study recruited one-hundred patients hospitalized for less than 48 h for clinical or surgical reasons. The HAP was administered at baseline and after 48 h in a test–retest design). The International Physical Activity Questionnaire (IPAQ-6) was also administered at baseline, ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2017 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Débora Stripari Schujmann, Adriana Cláudia Lunardi, Carolina Fu,
Enhanced mobility in the Intensive Care Unit (ICU) could minimize the negative effects of critical illness, such as declines in cognitive, muscular, respiratory, and functional capacity. We aim to compare the functional status at ICU discharge of patients who underwent a progressive mobilization protocol versus patients who received conventional physiotherapy. We also examine the level of physical activity in the ICU, the degree of pulmonary and muscle function, and the length of stay to analyze ...
Tópico(s): Family and Patient Care in Intensive Care Units
2018 - Springer Science+Business Media | Trials
Produção Nacional
Revisado por pares
Maria do Socorro Simões, Isabel FF Garcia, Lucíola da Cunha Menezes Costa, Adriana Cláudia Lunardi,
The Life-Space Assessment (LSA) assesses mobility from the spaces that older adults go, and how often and how independent they move. Despite its increased use, LSA measurement properties remain unclear. The aim of the present study was to analyze the content validity, reliability, construct validity and interpretability of the LSA for Brazilian community-dwelling older adults.In this clinimetric study we analyzed the measurement properties (content validity, reliability, construct validity and interpretability) ...
Tópico(s): Older Adults Driving Studies
2018 - Wiley | Geriatrics and gerontology international/Geriatrics & gerontology international
Produção Nacional
Revisado por pares
Nayara Alexia Moreno, Bruno Garcia de Aquino, Isabel Fialho Fontenele Garcia, Lucas Spadoni Tavares, Larissa Francielly Costa, Ivens Willians Silva Giacomassi, Adriana Cláudia Lunardi,
Does advice from a physiotherapist about the importance of staying physically active during hospitalisation improve activity, mobility, strength, length of stay, and complications in older inpatients? What barriers to physical activity during hospitalisation do older inpatients perceive?Randomised controlled trial with concealed allocation, intention-to-treat analysis, and blinded assessment.Sixty-eight people who were aged > 60 years and admitted to a university hospital ward.In addition to usual ...
Tópico(s): Physical Activity and Health
2019 - Elsevier BV | Journal of physiotherapy
Produção Nacional
Revisado por pares
Andrea Fontana, Alexandre Días Lópes, Adriana Cláudia Lunardi,
Tópico(s): Diet and metabolism studies
2019 - Springer Science+Business Media | Obesity Surgery
Produção Nacional
Revisado por pares
Débora Stripari Schujmann, Tamires Teixeira Gomes, Adriana Cláudia Lunardi, Murilo Zoccoler Lamano, Aretha Fragoso, Mayara Couto Pimentel, Claudia Neri Peso, Priscila Almeida Araújo, Carolina Fu,
The aim was to investigate whether patients who participated in a mobility program in the ICU performed better on functional status, muscle, mobility, and respiratory assessments upon discharge than patients who received conventional physiotherapy.
Tópico(s): Family and Patient Care in Intensive Care Units
2019 - Lippincott Williams & Wilkins | Critical Care Medicine
Produção Nacional
Revisado por pares
Marieta Cabral Amaral Da Cunha, Jociane Schardonga, Natiele Camponogara Righi, Adriana Cláudia Lunardi, Guadalupe Nery de Sant’Anna, Larissa Padrão Isensee, Rafaella Fagundes Xavier, Kaciane Roberta Brambatti, José Eduardo Pompeu, Fabiano Frâncio, Luiza Martins Faria, Rozana Astolfi Cardoso, Antônio Marcos Vargas da Silva, Camila de Christo Dorneles, Roberta Weber Werle, Juliana Carvalho Ferreira, Rodrigo Della Méa Plentz, Celso Ricardo Fernandes Carvalho,
Objective: To identify factors that lead to a positive oxygenation response and predictive factors of mortality after prone positioning. Methods: This was a retrospective, multicenter, cohort study involving seven hospitals in Brazil. Inclusion criteria were being > 18 years of age with a suspected or confirmed diagnosis of COVID-19, being on invasive mechanical ventilation, having a PaO2/FIO2 ratio < 150 mmHg, and being submitted to prone positioning. After the first prone positioning session, a 20 ...
Tópico(s): Cardiac Arrest and Resuscitation
2022 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Produção Nacional
Revisado por pares
Roberto de Cleva, Marianna Siqueira de Assumpção, Flavia Sasaya, Natalia Chaves, Marco Aurélio Santo, Claudia Fló, Adriana Cláudia Lunardi, Wilson Jacob Filho,
OBJECTIVE: Patients undergoing abdominal surgery are at risk for pulmonary complications.The principal cause of postoperative pulmonary complications is a significant reduction in pulmonary volumes (FEV 1 and FVC) to approximately 65-70% of the predicted value.Another frequent occurrence after abdominal surgery is increased intra-abdominal pressure.The aim of this study was to correlate changes in pulmonary volumes with the values of intra-abdominal pressure after abdominal surgery, according to ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
2014 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Andréia Ferreira Nunes, Cristiane Orlanda Bezerra, Jaqueline dos Santos Custódio, Celena Freire Friedrich, Indiara Soares Oliveira, Adriana Cláudia Lunardi,
BackgroundThe clinimetric properties of the Brief Fatigue Inventory (BFI) were not previously assessed in oncological patients hospitalized for chemotherapy.ObjectiveTo assess the reliability and validity of the construct, ceiling and floor effects, and responsiveness of the BFI administered to oncological patients hospitalized for chemotherapy.MethodsThis test-retest study included 100 oncological patients hospitalized for chemotherapy. The clinimetric properties tested were as follows: internal ...
Tópico(s): Cancer-related cognitive impairment studies
2018 - Elsevier BV | Journal of Pain and Symptom Management
Produção Nacional
Revisado por pares
Elinaldo da Conceição dos Santos, Juliana de Souza da Silva, Marcus Titus Trindade de Assis Filho, Marcela Brito Vidal, Moisés de Castro Monte, Adriana Cláudia Lunardi,
In patients with a collection of fluid in the pleural space, do mobilisation and respiratory techniques: shorten the drainage period and length of hospital stay; improve respiratory function and oxygenation; and prevent pulmonary complications? Does the addition of positive airway pressure to this regimen further improve the effects?Randomised controlled trial with three intervention arms, concealed allocation, intention-to-treat analysis and blinded assessment.One hundred and fifty-six inpatients ...
Tópico(s): Airway Management and Intubation Techniques
2019 - Elsevier BV | Journal of physiotherapy
Giovani Assunção de Azevedo Alves, Bruno Prata Martinez, Adriana Cláudia Lunardi,
To compare the measurement properties (internal consistency, intra and interrater reliability, construct validity, and ceiling and floor effects) of the Functional Status Score for the ICU (FSS-ICU) and the Functional Independence Measure (FIM-motor domain).In this study of measurement properties, the FSS-ICU and FIM were applied to 100 patients (72.1 ± 15.9 years; 53% male; Sequential Organ Failure Assessment = 11.0 ± 3.5 points, Simplified Acute Physiology Score 3 = 50.2 ± 16.8 points) in an intensive care ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2019 - Associação de Medicina Intensiva Brasileira | Revista Brasileira de Terapia Intensiva