Adriana Marques, Kyung J. Kwon‐Chung, Steven M. Holland, Maria L. Turner, John I. Gallin,
... a Patient with Chronic Granulomatous Disease Get access Adriana R. Marques, Adriana R. Marques From the Laboratories of Clinical Investigation and Host ...
Tópico(s): Skin Diseases and Diabetes
1995 - Oxford University Press | Clinical Infectious Diseases
Michael C. Sneller, Adriana Marques, Chengcai Liang, Joyce Y. Chung,
... COVID-19 Sequelae and ImmunityFREEMichael C. Sneller, MD, Adriana R. Marques, MD, C. Jason Liang, PhD, and Joyce Y. ... C.S., A.R.M., C.J.L.), Adriana R. Marques, MDNational Institute of Allergy and Infectious Diseases, National ... Baseline Findings Michael C. Sneller , C. Jason Liang , Adriana R. Marques , Joyce Y. Chung , Sujata M. Shanbhag , Joseph R. ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - American College of Physicians | Annals of Internal Medicine
Produção Nacional
Revisado por pares
Daisy Maria Rizatto Tronchin, Vera Lúcia Mira, Marina Peduzzi, Maria Helena Trench Ciampone, Marta Maria Melleiro, Jaqueline Alcântara Marcelino da Silva, Adriana Marques da Silva, Jaqueline Maria de Sousa Soares,
Estudo exploratório-descrito cujos objetivos foram identificar, caracterizar e analisar as atividades educativas desenvolvidas com profissionais de saúde, à luz das concepções de integralidade, trabalho em equipe e educação permanente. A coleta de dados ocorreu em três hospitais do Município de São Paulo, através de entrevista dirigida a informantes-chave, representantes de todas as categorias profissionais. As entrevistas foram gravadas e transcritas, as informações sistematizadas em categorias ...
Tópico(s): Healthcare during COVID-19 Pandemic
2009 - UNIVERSIDADE DE SÃO PAULO | Revista da Escola de Enfermagem da USP
Adriana Marques, Margaret R. Brown, Thomas A. Fleisher,
It has been reported that patients with "chronic Lyme disease" have a decreased number of natural killer cells, as defined by the CD57 marker. We performed immunophenotyping in 9 individuals with post-Lyme disease syndrome, 12 who recovered from Lyme disease, and 9 healthy volunteers. The number of natural killer cells was not significantly different between the groups.
Tópico(s): Viral Infections and Vectors
2009 - American Society for Microbiology | Clinical and Vaccine Immunology
Tom G. Schwan, Sandra J. Raffel, Merry E. Schrumpf, Larry S. Webster, Adriana Marques, Robyn Spano, Michael P. Rood, Joseph K. Burns, Renjie Hu,
Abstract The primary cause of tick-borne relapsing fever in western North America is Borrelia hermsii, a rodent-associated spirochete transmitted by the fast-feeding soft tick Ornithodoros hermsi. We describe a patient who had an illness consistent with relapsing fever after exposure in the mountains near Los Angeles, California, USA. The patient's convalescent-phase serum was seropositive for B. hermsii but negative for several other vector-borne bacterial pathogens. Investigations at the exposure ...
Tópico(s): Mosquito-borne diseases and control
2009 - Centers for Disease Control and Prevention | Emerging infectious diseases
Yo Hoshino, Harutaka Katano, Ping Zou, Patricia Hohman, Adriana Marques, Stephen K. Tyring, Dean Follmann, Jeffrey I. Cohen,
ABSTRACT Epstein-Barr virus (EBV) establishes a latent infection in B cells in the blood, and the latent EBV load in healthy individuals is generally stable over time, maintaining a “set point.” It is unknown if the EBV load changes after long-term antiviral therapy in healthy individuals. We treated volunteers with either valacyclovir (valaciclovir) or no antiviral therapy for 1 year and measured the amount of EBV DNA in B cells every 3 months with a novel, highly sensitive assay. The number of EBV- ...
Tópico(s): Parvovirus B19 Infection Studies
2009 - American Society for Microbiology | Journal of Virology
Paolo A. Muraro, Klaus‐Peter Wandinger, Bibiana Bielekova, Bruno Gran, Adriana Marques, Ursula Utz, Henry F. McFarland, Steven Jacobson, Roland Martinꝉ,
T cells recognizing self or microbial antigens may trigger or reactivate immune‐mediated diseases. Monitoring the frequency of specific T cell clonotypes to assess a possible link with the course of disease has been a difficult task with currently available technology. Our goal was to track individual candidate pathogenic T cell clones, selected on the basis of previous extensive studies from patients with immune‐mediated disorders of the CNS, including multiple sclerosis, HTLV‐I associated myelopathy/ ...
Tópico(s): T-cell and B-cell Immunology
2002 - Oxford University Press | Brain
Gian Vitor Barbosa, Mauren Mosquera Cruz, Laílton Soares, Adriana Marques Rocha, Carlos Ribeiro, Antônio José Rosário Sousa, J.L.C. Ferreira, E.J.S. Barreto, Wesley Cecilio Silva, AS. Santos,
The aim of this report is to depict the proceedings for obtaining new RB varieties of sugarcane in Alagoas, Brazil. This process starts at Sugarcane Flowering and Crossing Station, At Serra do Ouro. Serra do Ouro is located at 9o13’S 35o 50’W, 450m above sea level and 35km from the sea. The Winter (the wet season) extends from March to August. The Summer (the dry season) extends from September to February, and under these conditions the flowering process takes place and the annual cross station activity ...
Tópico(s): Sugarcane Cultivation and Processing
2002 - Brazilian Society of Plant Breeding | Crop Breeding and Applied Biotechnology
Adriana Marques, Dale S. Martin, Mario T. Philipp,
ABSTRACT The C6 enzyme-linked immunosorbent assay (ELISA), based on a peptide (C6) that reproduces the sequence of invariable region 6 of VlsE, the antigenic variation protein of Borrelia burgdorferi , has been shown to be a sensitive and specific test for the serologic diagnosis of Lyme disease. We now report that none of 29 uninfected individuals vaccinated with the recombinant OspA vaccine had an antibody response to the C6 peptide. The C6 peptide ELISA can be used to diagnose Lyme disease in patients ...
Tópico(s): Mosquito-borne diseases and control
2002 - American Society for Microbiology | Journal of Clinical Microbiology
Produção Nacional
Revisado por pares
William Alberto Cañón-Franco, L. E O. Yai, Adriana Marques Joppert, Celso Eduardo de Souza, Sandra Regina Nicoletti D’Áuria, J. P. Dubey, Solange María Gennari,
Capybaras (Hidrochoeris hidrochoeris) are 1 of the largest rodents used for meat in South and Central America. Prevalence of anti-Toxoplasma gondii antibodies in 149 feral H. hidrochoeris from the state of São Paulo, Brazil, was evaluated using the indirect immunofluorescent antibody test (IFAT) and the modified agglutination test (MAT). Using IFAT, antibodies (>1:16) were found in 104 (69.8%) and with the MAT, antibodies (>1:25) were found in 63 (42.3%) capybaras. This is the first report of prevalence ...
Tópico(s): Parasitic Infections and Diagnostics
2003 - American Society of Parasitologists | Journal of Parasitology
Lawrence I. Shotland, Mary Ann Mastrioanni, Daniel L. Choo, Yvonne M. Szymko-Bennett, Leonard G. Dally, Anita Pikus, Kathryn Sledjeski, Adriana Marques,
In Brief Objective The purpose of this study was to characterize auditory function in patients diagnosed with post-treatment Lyme disease syndrome (PTLDS). Design Eighteen patients with PTLDS were evaluated and compared to a normal population. Evaluations consisted of pure tone and speech thresholds, word recognition (WRS), acoustic immittance battery, auditory brain stem response (ABR), and loudness discomfort level (LDL). Both seropositive and seronegative patients were evaluated. Audiologists were ...
Tópico(s): Dermatological diseases and infestations
2003 - Lippincott Williams & Wilkins | Ear and Hearing
Mario T. Philipp, Adriana Marques, Paul T. Fawcett, Leonard G. Dally, Dale S. Martin,
ABSTRACT Management of Lyme disease would benefit from a test to assess therapy outcome. Such a test could be employed to ascertain if treatment of early Lyme disease was successful and would be helpful to clinicians assessing patients with lingering posttreatment symptoms. We reported recently that levels of the antibody to C 6 , a Borrelia burgdorferi- derived peptide that is used as an antigen in the C 6 -Lyme diagnostic test, declined after successful antibiotic treatment of Lyme borreliosis patients. ...
Tópico(s): Dermatological diseases and infestations
2003 - American Society for Microbiology | Journal of Clinical Microbiology
Ricardo Santos, E. Santos, Susana Gonçalves, Adriana Marques, João Sequeira, P Abecasis, Manuela Cadete,
Aerococcus urinae is rarely reported as a human pathogen. The pathogenesis of this gram-positive coccus is not fully understood. It has been identified as a cause of urinary tract infections but may be associated with severe infections such as endocarditis and septicaemia. This paper presents a case of lymphadenitis caused by A. urinae.
Tópico(s): Streptococcal Infections and Treatments
2003 - Informa | Scandinavian Journal of Infectious Diseases
Rendi Murphree Bacon, Brad J. Biggerstaff, Martin E. Schriefer, Robert D. Gilmore, Mario T. Philipp, Allen C. Steere, Gary P. Wormser, Adriana Marques, Barbara J. B. Johnson,
In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG responses to a synthetic peptide homologous to a conserved internal sequence of VlsE (C6), and IgM responses to a synthetic peptide comprising the C-terminal 10 amino acid residues of a B. burgdorferi outer-surface protein C (pepC10) were evaluated by kinetic enzyme-linked immunoassay. At 99% specificity, the overall sensitivities for detecting ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2003 - Oxford University Press | The Journal of Infectious Diseases
Studies have shown that most patients diagnosed with chronic Lyme disease either have no objective evidence of previous or current infection with Borrelia burgdorferi or are patients who should be classified as having post-Lyme disease syndrome, which is defined as continuing or relapsing nonspecific symptoms (such as fatigue, musculoskeletal pain, and cognitive complaints) in a patient previously treated for Lyme disease. Despite extensive study, there is currently no clear evidence that post-Lyme ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2008 - Elsevier BV | Infectious Disease Clinics of North America
Diana Londoño, Adriana Marques, Ronald L. Hornung, Diego Cadavid,
Abstract During relapsing fever borreliosis, a high pathogen load in the blood occurs at times of peak bacteremia. Specific IgM Abs are responsible for spirochetal clearance so in absence of B cells there is persistent high-level bacteremia. Previously, we showed that B cell-deficient mice persistently infected with Borrelia turicatae produce high levels of IL-10 and that exogenous IL-10 reduces bacteremia. This suggested that IL-10 helps reduce bacteremia at times of high pathogen load by a B cell- ...
Tópico(s): Vector-Borne Animal Diseases
2008 - American Association of Immunologists | The Journal of Immunology
Peter D. Burbelo, Alexandra T. Issa, Kathryn H. Ching, Jeffrey I. Cohen, Michael J. Iadarola, Adriana Marques,
ABSTRACT There is currently a need for improved serological tests for the diagnosis and monitoring of Lyme disease, an infection caused by Borrelia burgdorferi . In the present study, we evaluated luciferase immunoprecipitation systems (LIPSs) for use for profiling of the antibody responses to a panel of B. burgdorferi proteins for the diagnosis of Lyme disease. Initially, serum samples from a cohort of patients and controls ( n = 46) were used for training and were profiled by the use of 15 different ...
Tópico(s): Mosquito-borne diseases and control
2010 - American Society for Microbiology | Clinical and Vaccine Immunology
Produção Nacional
Revisado por pares
Adriana Marques Battagin, Simone Dal Corso, Carmen Lúcia Rondon Soares, Sílvia Regina Ferreira, Agnes Letícia, Cintia de Souza, Carla Malaguti,
FUNDAMENTO: O exercício resistido tem sido atualmente recomendado como componente adjunto do exercício aeróbico no programa de treinamento físico direcionado ao tratamento e controle da hipertensão arterial sistêmica (HAS). Entretanto, o mesmo ainda não tem sido amplamente incorporado na prática clínica, possivelmente pela escassez de evidências disponíveis sobre os limites seguros da resposta pressórica aguda nessa modalidade. OBJETIVO: Investigar o efeito agudo do exercício resistido progressivo, ...
Tópico(s): Blood Pressure and Hypertension Studies
2010 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Fábio Henrique Pinheiro, Adriana Marques de Oliveira, Ana Claúdia Vieira Cardoso, Simone Aparecida Capellini,
Auditory processing disorder is a clinical entity that may be associated with several neuropathological disorders - learning disabilities among them.To characterize and compare the performance of students with and without learning disabilities in speech tests with and without background noise, dichotic listening tests, alternating dissyllable test.40 students of both genders, ranging from 8 to 12 years of age participated in this study. They were divided in two groups: GI - 20 students with learning ...
Tópico(s): Hearing Impairment and Communication
2010 - Elsevier BV | Brazilian Journal of Otorhinolaryngology
Produção Nacional
Adriana Marques, Gustavo Chicaybam, Mariana Taranto Araujo, Luciana Ribeiro Trajano Manhães, Armando U. O. Sabaa‐Srur,
O Brasil produz cerca de 140 milhões de toneladas de alimento por ano; entretanto, a fome ainda é um dos maiores problemas enfrentados por grande parte da sua população. O aproveitamento integral de alimentos é uma alternativa para suprir as necessidades nutricionais e contribuir para reduzir o lixo orgânico. Nesse sentido, cascas, talos, sementes e outras partes, tradicionalmente não utilizadas como alimentos, podem ser incorporadas na dieta alimentar. Estudos revelam que cascas de muitas hortifrutícolas ...
Tópico(s): Agricultural and Food Sciences
2010 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
Tópico(s): Dermatological diseases and infestations
2010 - Springer Science+Business Media | Current Allergy and Asthma Reports
Produção Nacional
Revisado por pares
Lucila Maria de Souza Campos, Carolina Andion, Maurício Serva, Adriana Marques Rossetto, Jairo José Assumpção,
Tópico(s): Business and Management Studies
2010 - Springer Science+Business Media | VOLUNTAS International Journal of Voluntary and Nonprofit Organizations
Hans Gelderblom, Diana Londoño, Yunhong Bai, Erik S. Cabral, Jacqueline A. Quandt, Ron Hornung, Roland Martinꝉ, Adriana Marques, Diego Cadavid,
Relapsing fever (RF) is a multisystemic borrelial infection with frequent neurologic involvement referred to as neuroborreliosis. The absence of an effective antibody response results in persistent infection. To study the consequences to the brain of persistent infection with the RF spirochete Borrelia turicatae, we studied B cell (Igh6−/−) and B and T (Rag1−/−) cell-deficient mice inoculated with isogenic serotypes 1 (Bt1) or 2 (Bt2). We found that Bt1 was more tissue tropic than Bt2, not only for brain ...
Tópico(s): Mosquito-borne diseases and control
2007 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Hans Gelderblom, Jens Schmidt, Diana Londoño, Yunhong Bai, Jacqueline A. Quandt, Ron Hornung, Adriana Marques, Roland Martinꝉ, Diego Cadavid,
Relapsing fever is an infection characterized by peaks of spirochetemia attributable to antibody selection against variable serotypes. In the absence of B cells, serotypes cannot be cleared, resulting in persistent infection. We previously identified differences in spirochetemia and disease severity during persistent infection of severe combined immunodeficiency mice with isogenic serotypes 1 (Bt1) or 2 (Bt2) of Borrelia turicatae. To investigate this further, we studied pathogen load, clinical disease, ...
Tópico(s): Vector-Borne Animal Diseases
2007 - Elsevier BV | American Journal Of Pathology
Abhishek Chandra, Gary P. Wormser, Adriana Marques, Norman Latov, Armin Alaedini,
ABSTRACT Patients with post-Lyme disease syndrome (PLDS) report persistent symptoms of pain, fatigue, and/or concentration and memory disturbances despite antibiotic treatment for Lyme borreliosis. The etiopathogenesis of these symptoms remains unknown and no effective therapies have been identified. We sought to examine the antiborrelia antibody profile in affected patients with the aim of finding clues to the mechanism of the syndrome and its relationship to the original spirochetal infection. ...
Tópico(s): Dermatological diseases and infestations
2011 - American Society for Microbiology | Clinical and Vaccine Immunology
Abhishek Chandra, Norman Latov, Gary P. Wormser, Adriana Marques, Armin Alaedini,
The VlsE lipoprotein of Borrelia burgdorferi elicits a strong immune response during the course of Lyme disease. The present study was aimed at characterization of the epitopes of VlsE targeted by the antibody response in patients with post-Lyme disease syndrome, a condition characterized by persisting symptoms of pain, fatigue, and/or neurocognitive impairment despite antibiotic treatment of B. burgdorferi infection. Epitope mapping was carried out using microarrays that contained synthesized overlapping ...
Tópico(s): Viral Infections and Vectors
2011 - Elsevier BV | Clinical Immunology
Vince Pozsgay, Joanna Kübler-Kiełb, Bruce Coxon, Adriana Marques, John B. Robbins, Rachel Schneerson,
Borrelia burgdorferi is the etiological agent for Lyme disease (LD), the most common vector borne disease in the United States. There is no human vaccine against LD currently available. Our approach to a vaccine is based on its surface-exposed glycolipids. One group of these glycolipids termed BBGL-2 consists of 1,2-di-O-acyl-3-O-(α-d-galactopyranosyl)-sn-glycerol congeners having palmitic, oleic, stearic, linoleic, and myristic acids. In order to delineate the immunodominant region(s) of the BBGL- ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2011 - Elsevier BV | Carbohydrate Research
Jeffrey I. Cohen, Elaine S. Jaffe, Janet K. Dale, Stefania Pittaluga, Helen E. Heslop, Cliona M. Rooney, Stephen Gottschalk, Catherine M. Bollard, V. Koneti Rao, Adriana Marques, Peter D. Burbelo, Siu-Ping Turk, Rachael Fulton, Alan S. Wayne, Richard F. Little, Mitchell S. Cairo, Nader Kim El‐Mallawany, Daniel H. Fowler, Claude Sportès, Michael Bishop, Wyndham H. Wilson, Stephen E. Straus,
Abstract Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or protein in lymphocytes in tissues. We present our experience with CAEBV during the last 28 years, including the first 8 cases treated with hematopoietic stem cell transplantation in the United States. Most cases of CAEBV have been reported from Japan. Unlike CAEBV in Japan, where EBV is nearly always found in T or natural ...
Tópico(s): Eosinophilic Disorders and Syndromes
2011 - Elsevier BV | Blood
Riccardo Cassiani‐Ingoni, Erik S. Cabral, Jan D. Lünemann, Zoila Garza, Tim Magnus, Hans Gelderblom, Peter J. Munson, Adriana Marques, Roland Martinꝉ,
The spirochete Borrelia burgdorferi is the agent of Lyme disease, which causes central nervous system manifestations in up to 20% of patients. We investigated the response of human brain microglial cells, glial progenitors, neurons, astrocytes, as well as peripheral blood monocytes to stimulation with B. burgdorferi. We used oligoarrays to detect changes in the expression of genes important for shaping adaptive and innate immune responses. We found that stimulation with B. burgdorferi lysate increased ...
Tópico(s): Immune Response and Inflammation
2006 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Jan D. Lünemann, Hans Gelderblom, Mireia Sospedra, Jacqueline A. Quandt, Clemencia Pinilla, Adriana Marques, Roland Martinꝉ,
Neurological manifestations of Lyme disease are usually accompanied by inflammatory changes in the cerebrospinal fluid (CSF) and the recruitment of activated T cells into the CSF compartment. In order to characterize the phenotype and identify target antigens of CSF-infiltrating T cells in early neuroborreliosis with central nervous system (CNS) involvement, we combined T-cell cloning, functional testing of T-cell responses with positional scanning synthetic combinatorial peptide libraries, and biometric ...
Tópico(s): Viral Infections and Vectors
2006 - American Society for Microbiology | Infection and Immunity