Rita A. Ribeiro, Ana Moreira, Pim van den Broek, Afonso Pimentel,
During software development, many decisions need to be made to guarantee the satisfaction of the stakeholders' requirements and goals. The full satisfaction of all of these requirements and goals may not be possible, requiring decisions over conflicting human interests as well as technological alternatives, with an impact on the quality and cost of the final solution. This work aims at assessing the suitability of multi-criteria decision making (MCDM) methods to support software engineers' decisions. ...
Tópico(s): Software Engineering Research
2010 - Elsevier BV | Decision Support Systems
Produção Nacional
Revisado por pares
Helena Cristina Cardoso Coelho, Stefanie Costa Pinto Lopes, João Paulo Diniz Pimentel, Paulo Afonso Nogueira, Fábio Trindade Maranhão Costa, André M. Siqueira, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro, Adriana Malheiro, Marcus Lacerda,
Background Although thrombocytopenia is a hematological disorder commonly reported in malarial patients, its mechanisms are still poorly understood, with only a few studies focusing on the role of platelets phagocytosis. Methods and Findings Thirty-five malaria vivax patients and eight healthy volunteers (HV) were enrolled in the study. Among vivax malaria patients, thrombocytopenia (<150,000 platelets/µL) was found in 62.9% (22/35). Mean platelet volume (MPV) was higher in thrombocytopenic patients ...
Tópico(s): Platelet Disorders and Treatments
2013 - Public Library of Science | PLoS ONE
Jennifer H. Benbow, Kyle J. Thompson, Heidi L. Cope, Elizabeth Brandon‐Warner, Catherine R. Culberson, Krista Bossi, Ting Li, Mark W. Russo, Keith S. Gersin, Iain H. McKillop, Andrew S. deLemos, Laura W. Schrum,
... with hepatitis, cirrhosis, or HCC.27Soares J.B. Pimentel-Nunes P. Afonso L. Rolanda C. Lopes P. Roncon-Albuquerque Jr., ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2015 - Elsevier BV | American Journal Of Pathology
Victor Pimentel, Rita Afonso, Mónica Nunes, Maria Luísa Vieira, Daniel Bravo‐Barriga, Eva María Frontera Carrión, Manuel Martínez, André Pereira, Carla Maia, Maria das Neves Paiva‐Cardoso, Ferdinando B. Freitas, Ana Abecasis, Ricardo Parreira,
The large diversity of new tick-borne phleboviruses, and the negative impacts of the virulent viruses on human/animal health have led to a growing interest in their analysis. In this report, new insights are brought out into the diversity of putative phleboviruses circulating in Portugal (both the continental territory and the islands of São Miguel, in the Azores, and Madeira), as well as in the Spanish western regions of Extremadura and Castilla and León. Phlebovirus sequences were frequently detected ( ...
Tópico(s): Plant Virus Research Studies
2019 - Elsevier BV | Ticks and Tick-borne Diseases
Mário Dinis‐Ribeiro, Pedro Pimentel‐Nunes, Mariana Afonso, Natália R. Costa, Carlos Lopes, André Moreira,
Background EMR is an accepted method for resection of superficial lesions in the GI tract. However, because it leads, not unusually, to piecemeal resection, histopathologic interpretation problems and an increased risk of recurrence are noticeable. Endoscopic submucosal dissection (ESD) allows a higher rate of en bloc resection, with low recurrence. Nevertheless, this technique, namely in the upper-GI tract, has rarely been described in Western countries, probably because of the rarity of gastric cancer in ...
Tópico(s): Metastasis and carcinoma case studies
2009 - Elsevier BV | Gastrointestinal Endoscopy
Pedro Pimentel‐Nunes, Luís Pedro Afonso, Paula Lopes, Roberto Roncon‐Albuquerque, Nádia Gonçalves, Rui Henrique, Luís Moreira‐Dias, Adelino Leite‐Moreira, Mário Dinis‐Ribeiro,
TLRs are important innate immunity receptors. Even though TLR2, 4 and 5 appear to be important for Helicobacter pylori (HP) recognition, their role in the evolution of gastritis to more advanced lesions is still unknown. To compare the expression of TLR2, 4 and 5 in normal gastric mucosa, HP+ gastritis, intestinal metaplasia, dysplasia and adenocarcinoma. Immunohistochemistry for TLR2, 4 and 5 was performed with anti-TLR2-TLR4-TLR5 antibodies in 117 histological samples of normal gastric mucosa (n = ...
Tópico(s): Immune Response and Inflammation
2011 - Springer Science+Business Media | Pathology & Oncology Research
João–Bruno Soares, Pedro Pimentel‐Nunes, Luís Pedro Afonso, Carla Rolanda, Paula Lopes, Roberto Roncon‐Albuquerque, Nádia Gonçalves, Inês Boal‐Carvalho, Fernando Pardal, Susana Lopes, Guilherme Macedo, Lúcio Lara Santos, Rui Henrique, Luís Moreira‐Dias, Raquel Gonçalves, Mário Dinis‐Ribeiro, Adelino Leite‐Moreira,
We evaluated expression of TLR2, TLR4 and proinflammatory genes [NF-κB, TNF-α, cyclooxygenase-2 (COX-2)] in liver samples of patients in different stages of liver disease. Fifteen patients with unexplained transaminases elevation (reference group), 22 with viral chronic hepatitis (hepatitis group), 14 with virus-induced severe fibrosis/cirrhosis (cirrhosis group) and 10 with hepatocarcinoma (hepatocarcinoma group) were consecutively included in the study. Quantification of TLR2, TLR4, NF-κB, TNF-α and ...
Tópico(s): Hepatitis B Virus Studies
2012 - SAGE Publishing | Innate Immunity
Diogo Libânio, Pedro Pimentel‐Nunes, Luís Pedro Afonso, Rui Henrique, Mário Dinis‐Ribeiro,
Endoscopic submucosal dissection (ESD) is an effective treatment for gastric superficial neoplasms and curative in 80-85% of the patients. The aims of this study were to identify risk factors for non-curative resection and metachronous development, and to evaluate patient management and outcome after non-curative resection.In this single-centre study, the outcome of consecutive patients submitted to gastric ESD was assessed during a minimum follow-up of 18 months. Univariate analysis and multivariate ...
Tópico(s): Metastasis and carcinoma case studies
2016 - Karger Publishers | GE Portuguese Journal of Gastroenterology
Cristina M. Monteiro, Cristina Sousa Coutinho Calheiros, Carla Pimentel-Rodrigues, Armando Silva-Afonso, Paula M. L. Castro,
Green roofs (GRs) are becoming a trend in urban areas, favouring thermal performance of buildings, promoting removal of atmospheric pollutants, and acting as possible water collection spots. Rainwater harvesting systems in buildings can also contribute to the management of stormwater runoff reducing flood peaks. These technologies should be enhanced in Mediterranean countries where water scarcity is increasing and the occurrence of extreme events is becoming very significant, as a result of climate ...
Tópico(s): Urban Stormwater Management Solutions
2016 - Pergamon Press | Water Science & Technology
Produção Nacional
Revisado por pares
Luiz Gonzaga Vaz Coelho, James Ramalho Marinho, Robert M. Genta, Laércio Tenório Ribeiro, Maria do Carmo Friche Passos, Schlioma Zaterka, Paulo Pimentel de Assumpção, Alfredo José Afonso Barbosa, Ricardo C. Barbuti, Lúcia Libanês Bessa Campelo Braga, Helenice Pankowski Breyer, Aloísio Carvalhaes, Décio Chinzon, Marcelo Cury, Gerson Domingues, Jorge Luiz Jorge, Ismael Maguilnik, Frederico Passos Marinho, Joaquim Prado de MORAES-FILHO, José Miguel Luz Parente, Celso Mirra de PAULA-E-SILVA, José PEDRAZZOLI-JÚNIOR, Ana Flávia Passos Ramos, Heinrich Seidler, José Nonato SPINELLI, José Vitor ZIR,
ABSTRACT Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25- ...
Tópico(s): Eosinophilic Esophagitis
2018 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Carla Pimentel-Rodrigues, Armando Siva-Afonso,
Circular economy can be considered not only in relation to building construction materials, but also in relation to resources that are used in the use phase of buildings, such as water, energy or even nutrients. On the other hand, some constructive solutions are becoming increasingly important in the current scenario of climate change, taking into account the need to increase the resilience of the urban environment and the mitigation of emissions. This is the case, for example, of green roofs and ...
Tópico(s): Wastewater Treatment and Reuse
2019 - IOP Publishing | IOP Conference Series Earth and Environmental Science
Carla Pimentel-Rodrigues, Armando Silva-Afonso,
It has become evident that, during this century, climate change will continue, affecting all regions of the planet. The expected impacts over the next few decades may differ from region to region, with some areas becoming humid and others drier. In regions such as the Mediterranean basin, the main expected impacts of climate change will be prolonged droughts and an increase in the intensity and frequency of heavy rains. Measures of mitigation and adaptation are particularly important in urban environments, ...
Tópico(s): Urban Heat Island Mitigation
2022 - Multidisciplinary Digital Publishing Institute | Water
Carla Pimentel-Rodrigues, Armando Silva-Afonso,
In addition to the possible contributions of buildings to mitigating CO2 emissions, increased attention is being paid to the potential impacts of climate change on urban environments. According to the United Nations, about 54% of the planet’s population currently lives in cities, but this percentage is expected to rise to 66% in 2050, which reveals the scale of this issue. This paper develops a reflection on the possible contributions of water-related building installations to mitigate emissions ...
Tópico(s): Flood Risk Assessment and Management
2019 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Andrew Ukleja, Bianca Afonso, Ronnie Pimentel, Samuel Szomstein, Raúl J. Rosenthal,
Tópico(s): Gastric Cancer Management and Outcomes
2008 - Springer Science+Business Media | Surgical Endoscopy
Produção Nacional
Revisado por pares
Danny Pimentel Claro, Valter Afonso Vieira, Raj Agnihotri, Rafael Serer,
Purpose As manufacturers and retailers aim to increase return on marketing investments, value- vs experience-related trade promotions gain attention. These two trade promotions become complicated in the presence of different retail format strategies (generalist vs specialist) and channel structures (direct to retailer vs distributors). Building on trade promotion literature, this study aims to show the main effect of value-related and experience-related trade promotions on retailers’ sales and the ...
Tópico(s): Digital Platforms and Economics
2021 - Emerald Publishing Limited | European Journal of Marketing
... D.P. Horsch M. Schröder S. Adler T. Afonso L.C. Aguilar-Pimentel J.A. Becker L. Garrett L. et al. ...
Tópico(s): Circadian rhythm and melatonin
2014 - Cell Press | Cell
... D.P. Horsch M. Schröder S. Adler T. Afonso L.C. Aguilar-Pimentel J.A. Becker L. Garrett L. et al. ...
Tópico(s): Planarian Biology and Electrostimulation
2014 - Elsevier BV | Cell stem cell
Alice Bastos, Joana Monteiro, Carla Faria, Maria Helena Pimentel, Sofia Silva, Carlos Miguel Figueiredo Afonso,
Abstract Objective: The present study aimed to analyze quality of life (QoL) in participants of community intervention programs (CIP) focused on healthy aging. Method : A multicenter cross-sectional study was carried out with 304 community-dwelling participants, aged 55 years old or more and living in three locations in Portugal. Half of these individuals (n=152) were involved in a CIP (intervention group). The intervention group was paired according to sex and age group with an equivalent number of participants ( ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Revista Brasileira de Geriatria e Gerontologia
Helmut Fuchs, Valérie Gailus‐Durner, Susanne Neschen, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar‐Pimentel, Lore Becker, Alexander Bohla, Julia Calzada‐Wack, Christian M. Cohrs, Anna Dewert, Barbara Fridrich, Lillian Garrett, Lisa Glasl, Alexander Götz, Wolfgang Hans, Sabine M. Hölter, Marion Horsch, Anja Hurt, Eva Janas, Dirk Janik, Melanie Kahle, Martin Kistler, Tanja Klein‐Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Birgit Rathkolb, Jan Rozman, Markus F. Scheerer, Evelyn Schiller, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Minxuan Sun, Wilfried Szymczak, Irina Treise, Ingrid Liliana Vargas Panesso, Alexandra Vernaleken, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Oliver Eickelberg, Jack Favor, Jochen Graw, Heinz Höfler, Christoph Höschen, Hugo A. Katus, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Holger Schulz, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Martin Hrabé de Angelis,
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC ...
Tópico(s): Gene Regulatory Network Analysis
2012 - Springer Science+Business Media | Mammalian Genome
Produção Nacional
Revisado por pares
Francisco Tardelli da Silva, Ismael Cristofer Baierle, Ricardo Gonçalves de Faria Corrêa, Miguel Afonso Sellitto, Fernanda Araújo Pimentel Peres, Liane Mählmann Kipper,
Industry 4.0 digital technologies in agribusiness will enable traditional farming systems to migrate to Agriculture 4.0. Open innovation emerges as an enabler for implementing these technologies and increased sector competitiveness. However, there are still doubts and questions about how technologies and open innovation relate to and will drive Agriculture 4.0. This study identified which digital technologies of Industry 4.0 have more adherence to agribusiness, what the barriers and facilitators ...
Tópico(s): Smart Agriculture and AI
2023 - Multidisciplinary Digital Publishing Institute | Sustainability
Frauke Neff, Diana Flores-Dominguez, Devon Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar‐Pimentel, Lore Becker, Lillian Garrett, Wolfgang Hans, Moritz M. Hettich, Richard Holtmeier, Sabine M. Hölter, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Birgit Rathkolb, Jan Rozman, Beatrix Naton, Rainer Ordemann, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Gerhard Ehninger, Jochen Graw, Heinz Höfler, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Jörg Stypmann, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Helmut Fuchs, Valérie Gailus‐Durner, Martin Hrabé de Angelis, Dan Ehninger,
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the FDA-approved mTOR inhibitor rapamycin represented the first demonstration of pharmacological extension of maximal lifespan in mammals. Longevity effects of rapamycin may, ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2013 - American Society for Clinical Investigation | Journal of Clinical Investigation
Produção Nacional
Revisado por pares
Rodrigo da Silva Lima, Júlio Carlos Afonso, Luiz Cláudio Ferreira Pimentel,
FASCINATION, FEAR AND SCIENCE.This work presents the discovery and the use of x-rays at the end of the XIXth and the beginning of the XXth century.X-rays greatly impacted science and everyday life.Their existence broke the idea that knowledge had reached a limiting step.In general, people regarded x-rays as a marvel of science, but reactions against their use were also found.Several applications were proposed, especially in medicine.However, little or no attention was paid to security measures, ...
Tópico(s): Science and Science Education
2009 - Brazilian Chemical Society | Química Nova
Andreia Rei, Raquel Ortigão, Mariana Canelas‐Pais, Luís Pedro Afonso, Pedro Pimentel‐Nunes, Mário Dinis‐Ribeiro, Diogo Libânio,
Background Surveillance after gastric endoscopic submucosal dissection (ESD) is recommended for all patients owing to the persistent risk of metachronous gastric lesions (MGLs). We developed and validated a prediction score to estimate MGL risk after ESD for early neoplastic gastric lesions, to define an individualized and cost-saving approach. Methods Clinical predictors and a risk score were derived from meta-analysis data. A retrospective, single-center, cohort study including patients with ≥ 3 years ...
Tópico(s): Metastasis and carcinoma case studies
2023 - Thieme Medical Publishers (Germany) | Endoscopy
Pedro Pimentel‐Nunes, Nádia Gonçalves, Inês Boal‐Carvalho, Luís Pedro Afonso, Paula Lopes, Roberto Roncon‐Albuquerque, Rui Henrique, Luís Moreira‐Dias, Adelino Leite‐Moreira, Mário Dinis‐Ribeiro,
Abstract Background Toll‐like receptors ( TLR ) are essential for H elicobacter pylori ( HP ) recognition. Their role in the progression of gastric lesions leading to cancer is not established. Aim To evaluate for the first time in humans the expression of TLR 2, TLR 4, and TLR 5, as well as the expression of other related molecules in the entire sequence of gastric lesions. Methods Biopsy samples (n = 80, 48% HP +) from normal mucosa, HP gastritis, metaplasia, dysplasia or adenocarcinoma were obtained from 44 ...
Tópico(s): Immune Response and Inflammation
2012 - Wiley | Helicobacter
Pedro Pimentel‐Nunes, Nádia Gonçalves, Inês Boal‐Carvalho, Luís Pedro Afonso, Paula Lopes, Roberto Roncon‐Albuquerque, João–Bruno Soares, Elisabete Cardoso, Rui Henrique, Luís Moreira‐Dias, Mário Dinis‐Ribeiro, Adelino Leite‐Moreira,
Background Animal data suggest that Toll-like receptors (TLR) may play an important role in colon carcinogenesis. Studies in humans to support that hypothesis are scarce. Aim To evaluate the expression of TLR2, TLR4 and TLR5, and the expression of several other related molecules, in different human colonic lesions. Methods Colon biopsy samples from normal mucosa, normal mucosa adjacent to lesion, adenoma or sporadic carcinoma were obtained from 35 consecutive patients undergoing colonoscopy. Quantification ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2012 - BMJ | Journal of Clinical Pathology
Pedro Pimentel‐Nunes, Francisco Ribeiro‐Mourão, Nuno Veloso, Luís Pedro Afonso, Manuel Jácome, Luís Moreira‐Dias, Mário Dinis‐Ribeiro,
Although endoscopic resection for the treatment of gastric superficial neoplastic lesions is an established first-line treatment in Eastern countries, its role has yet to be considered in Western guidelines, mostly due to a lack of long-term studies. The aim of this study was to describe long-term outcomes for endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of gastric neoplasias in Portugal.This was a single-center, retrospective, cohort study between ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2014 - Thieme Medical Publishers (Germany) | Endoscopy
Roberta Ferreira Pimentel, Roberto Sotto Maior Fortes de Oliveira, Maria das Graças Afonso Miranda Chaves, Carlos Nelson Elias, Marco Abdo Gravina,
OBJECTIVE: To evaluate and compare "in vitro" the maximum friction force generated by three types of esthetic brackets, two types of polycrystalline conventional ceramic brackets (20/40 and InVu) and one type of sapphire monocrystalline bracket (Radiance) in dry and artificial saliva wet settings. Also, to evaluate the influence exerted by artificial saliva on the friction forces of those brackets. METHODS: Tests were performed in dry and artificial saliva wet setting (Oral Balance) by using an EMIC ...
Tópico(s): Dental Implant Techniques and Outcomes
2013 - Dental Press Editora | Dental Press Journal of Orthodontics
Produção Nacional
Revisado por pares
Ana L.A. Marques, Sara Vilar Dantas Simões, Lisanka Ângelo Maia, Tatiane Rodrigues da Silva, Eldinê Gomes de Miranda Neto, Luciano A. Pimentel, José Augusto Bastos Afonso, Alexandre Cruz Dantas,
Relatam-se aspectos etiológicos, epidemiológicos, clínicos e patológicos de surtos de incoordenação motora observados após vacinação contra febre aftosa em bovinos nos estados da Paraíba e de Pernambuco. Os sinais de incoordenação motora foram observados em torno de 45 dias após a vacinação, realizada por via intramuscular nas regiões torácica e lombar e no local da aplicação havia aumento de volume. Um total de 24 animais foi acometido, sendo 6 no estado da Paraíba e 18 no estado de Pernambuco. ...
Tópico(s): Veterinary Orthopedics and Neurology
2012 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Revisado por pares
Luiz Cláudio Ferreira Pimentel, Camille Rodrigues Chaves, Layla Alvim Alves Freire, Júlio Carlos Afonso,
THE PAST.This work describes an overview of the use of chemicals in several commercial applications along the XXth century.The use of chemicals by men was largely empirical for many centuries, since there was no organized chemical and toxicological knowledge.During the XIXth century the chemical industry gained a crucial role in the development of technology, as evidenced by the extraordinary increase of new products and their incorporation into everyday life.Chemistry was considered a science capable ...
Tópico(s): Chemical Safety and Risk Management
2006 - Brazilian Chemical Society | Química Nova
Armando Silva-Afonso, Carla Pimentel-Rodrigues,
This article discusses a water‐efficiency certification and labeling initiative launched in Portugal in 2008 that is helping cut consumption and conserve stressed supplies. The Programa Nacional para o Uso Eficiente da Agua (PNUEA) urges labeling plumbing components in buildings (e.g., flushing systems, showers) in order to provide consumers with information about the devices’ water efficiency. The article also discusses the Associacao Nacional para a Qualidade nas Instalacoes Prediais (ANQIP), the ...
Tópico(s): Wastewater Treatment and Reuse
2010 - Wiley | American Water Works Association