Produção Nacional
Revisado por pares
Isabella Piassi Dias Godói, Leonardo Vinicius Dias da Silva, Abdur Razzaque Sarker, Itamar Megiddo, Alec Morton, Brian Godman, Samantha Alvarez‐Madrazo, Marion Bennie, Augusto Afonso Guerra,
Dengue is a serious global health problem endemic in Brazil. Consequently, our aim was to measure the costs and disease burden of symptomatic dengue infections in Brazil from the perspective of the Brazilian Public Health System (SUS) between 2000 and 2015, using Brazilian public health system databases. Specific age group incidence estimates were used to calculate the disability-adjusted life years (DALYs) to gain a better understanding of the disease burden. Areas covered: SUS spent almost USD159 ...
Tópico(s): Zoonotic diseases and public health
2018 - Informa | Expert Review of Vaccines
Produção Nacional
Revisado por pares
Juliana de Oliveira Costa, Celline Cardoso Almeida-Brasil, Brian Godman, Michael A. Fischer, Jonathan Dartnell, Aine Heaney, Carolina Greco Bernardes dos Santos, Francisco de Assis Acúrcio, Juliana Álvares Duarte Bonini Campos, Augusto Afonso Guerra,
The Brazilian National Health System provides high cost medicines through the Specialized Component of Pharmaceutical Assistance in accordance with the adherence to agreed Clinical Guidelines. However, physician compliance to these Guidelines, as well as the barriers and facilitators related to them and the influence on the subsequent quality of care provided is unknown. Consequently, the objectives of this article are to undertake a review of international experiences and scientific publications ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2016 - Oxford University Press | Journal of Pharmaceutical Health Services Research
Produção Nacional
Revisado por pares
Bráulio Cezar Bonoto, Vânia Eloísa de Araújo, Isabella Piassi Dias Godói, Lívia Lovato Pires de Lemos, Brian Godman, Marion Bennie, Leonardo Maurício Diniz, Augusto Afonso Guerra,
Diabetes Mellitus (DM) is a chronic disease that is considered a global public health problem. Education and self-monitoring by diabetic patients help to optimize and make possible a satisfactory metabolic control enabling improved management and reduced morbidity and mortality. The global growth in the use of mobile phones makes them a powerful platform to help provide tailored health, delivered conveniently to patients through health apps.The aim of our study was to evaluate the efficacy of mobile ...
Tópico(s): Diabetes Management and Education
2017 - JMIR Publications | JMIR mhealth and uhealth
Produção Nacional
Revisado por pares
Isabella Piassi Dias Godói, Lívia Lovato Pires de Lemos, Vânia Eloísa de Araújo, Braúlio Cesar Bonoto, Brian Godman, Augusto Afonso Guerra,
Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia ® ) was the first vaccine to gain regulatory approval to try and address this problem. Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine. Method: Meta-analysis and systematic review. Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2–16 years ...
Tópico(s): Viral Infections and Outbreaks Research
2017 - Future Medicine | Journal of Comparative Effectiveness Research
Produção Nacional
Revisado por pares
Isabella Piassi Dias Godói, André Soares Santos, Edna Afonso Reis, Lívia Lovato Pires de Lemos, Cristina Mariano Ruas, Juliana Álvares Duarte Bonini Campos, Francisco de Assis Acúrcio, Brian Godman, Augusto Afonso Guerra,
Introduction and objective: Dengue virus is a serious global health problem with an estimated 3.97 billion people at risk for infection worldwide. In December 2015, the first vaccine (CYD-TDV) for dengue prevention was approved in Brazil, developed by Sanofi Pasteur. However, given that the vaccine will potentially be paid via the public health system, information is need regarding consumers' willingness to pay for the dengue vaccine in the country as well as discussions related to the a possible ...
Tópico(s): COVID-19 epidemiological studies
2017 - Frontiers Media | Frontiers in Pharmacology
Produção Nacional
Revisado por pares
Marina Morgado Garcia, Mariana Michel Barbosa, Rondineli Mendes da Silva, Edna Afonso Reis, Juliana Álvares-Teodoro, Francisco de Assis Acúrcio, Brian Godman, Augusto Afonso Guerra,
Aim: Creation of a single indicator of access to medicines. Methods: Data collection was performed with individuals who obtained their medication from either public and/or private pharmacies. A Likert scale was used to measure the importance and satisfaction in relation to various access dimensions. Results: A total of 580 individuals were interviewed. Overall, participants attributed very similar importance scores to the dimensions of access to medicines. The results of the mean score of each dimension ...
Tópico(s): Medication Adherence and Compliance
2019 - Future Medicine | Journal of Comparative Effectiveness Research
Produção Nacional
Revisado por pares
Vinícius Pereira, Francisco de Assis Acúrcio, Augusto Afonso Guerra, Grazielle Dias da Silva, Mariângela Leal Cherchiglia,
Este trabalho descreve o perfil de utilização de medicamentos de indivíduos com hipertensão e/ou diabetes, que adquirem esses produtos por meio de uma rede pública de farmácias, com ênfase nas diferenças entre sexos. No primeiro bimestre de 2010 foram entrevistados indivíduos hipertensos e/ou diabéticos, em metade dos 64 municípios então participantes da Rede Farmácia de Minas. Os 4.777 entrevistados tinham em média 60,9 anos, fato que pode ter contribuído para a elevada média de medicamentos utilizados ( ...
Tópico(s): Health, Nursing, Elderly Care
2012 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Roberto F. Iunes, Manuela Villar Uribe, Janet Bonilla Torres, Marina Morgado Garcia, Juliana Álvares-Teodoro, Francisco de Assis Acúrcio, Augusto Afonso Guerra,
The bioethical debate in the world on who should pay for the continuity of post-trials treatment of patients that have medical indication remains obscure and introduces uncertainties to the patients involved in the trials. The continuity of post-trial treatment was only incorporated in the 2000s by the Helsinki Declaration. The Universal Declaration on Bioethics and Human Rights, published in 2006, points out that post-trial continuity may present a broader scope than just the availability of the ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2019 - BioMed Central | International Journal for Equity in Health
Produção Nacional
Revisado por pares
Francisco de Assis Acúrcio, Augusto Afonso Guerra, Michael Ruberson Ribeiro da Silva, Ramon Gonçalves Pereira, Brian Godman, Marion Bennie, Hacene Nedjar, Elham Rahme,
Objective: To evaluate persistence on conventional DMARDs (cDMARDs) and anti-TNF therapies, and to identify potential determinants of discontinuation among individuals with ankylosing spondylitis (AS) living in Brazil and Quebec, Canada.Methods: We conducted a cohort study of AS patients using health administrative data (2010-2015). One-year and 2-year persistence rates were assessed. Cox regression was used to identify potential determinants of therapy discontinuation.Results: One-year persistence ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2020 - Taylor & Francis | Current Medical Research and Opinion
Produção Nacional
Revisado por pares
Cristina Mariano Ruas, Marina Guimarães Lima, Anderson Lourenço da Silva, Graziele Dias Silva, Augusto Afonso Guerra, Francisco de Assis Acúrcio,
Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical ...
Tópico(s): Bone Metabolism and Diseases
2008 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Sônia Faria Mendes Braga, Rumenick Pereira da Silva, Augusto Afonso Guerra, Mariângela Leal Cherchiglia,
ABSTRACT: Objective: To analyze cancer-specific mortality (CSM) and other-cause mortality (OCM) among patients with prostate cancer that initiated treatment in the Brazilian Unified Health System (SUS), between 2002 and 2010, in Brazil. Methods: Retrospective observational study that used the National Oncological Database, which was developed by record-linkage techniques used to integrate data from SUS Information Systems, namely: Outpatient (SIA-SUS), Hospital (SIH-SUS), and Mortality (SIM-SUS). Cancer- ...
Tópico(s): Male Reproductive Health Studies
2021 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Revista Brasileira de Epidemiologia
Produção Nacional
Revisado por pares
Kathiaja Miranda Souza, Isabela Maia Diniz, Lívia Lovato Pires de Lemos, Nélio Gomes Ribeiro, Isabella de Figueiredo Zuppo, Juliana Álvares-Teodoro, Francisco de Assis Acúrcio, Álvaro Nagib Atallah, Augusto Afonso Guerra,
Background Relapsing-remitting multiple sclerosis (RRMM) is a chronic, progressive, inflammatory and immune-mediated disease that affects the central nervous system and is characterized by episodes of neurological dysfunction followed by a period of remission. The pharmacological strategy aims to delay the progression of the disease and prevent relapse. Interferon beta and glatiramer are commonly used in the Brazilian public health system and are available to patients who meet the guideline criteria. ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2020 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Wallace Breno Barbosa, Rosângela Maria Gomes, Brian Godman, Francisco de Assis Acúrcio, Augusto Afonso Guerra,
Introduction: Antipsychotics are widely prescribed for patients with schizophrenia. The Brazilian public health system provides these patients free of charge to patients and it is pertinent to evaluate their benefits.Objective: To evaluate the effectiveness of olanzapine and risperidone in the treatment of patients with schizophrenia in the real-world and assessing risk factors for their discontinuation through a national non-concurrent cohort with 16 years of follow-up.Methods: Three SUS administrative ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2020 - Taylor & Francis | Expert Review of Clinical Pharmacology
Produção Nacional
Revisado por pares
Rosângela Maria Gomes, Wallace Breno Barbosa, Brian Godman, Juliana de Oliveira Costa, Nélio Gomes Ribeiro, Charles Simão Filho, Mariângela Leal Cherchiglia, Francisco de Assis Acúrcio, Augusto Afonso Guerra,
The maintenance of patients with renal transplant typically involves two or more drugs to prevent rejection and prolong graft survival. The calcineurin inhibitors (CNI) are the most commonly recommended medicines in combinations with others. While immunosuppressive treatment regimens are well established, there is insufficient long-term effectiveness data to help guide future management decisions. The study analyzes the effectiveness of treatment regimens containing CNI after renal transplantation ...
Tópico(s): Neurological Complications and Syndromes
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Produção Nacional
Revisado por pares
Lívia Lovato Pires de Lemos, Augusto Afonso Guerra, Marisa Santos, Carlos Alberto da Silva Magliano, Isabela Maia Diniz, Kathiaja Miranda Souza, Ramon Gonçalves Pereira, Juliana Álvares-Teodoro, Brian Godman, Marion Bennie, Ivan Ricardo Zimmermann, Vânia Crisitna Canuto dos Santos, Clarice Alegre Pretramale, Francisco de Assis Acúrcio,
In Brazil, inclusion and exclusion of health technologies within the Unified Health System (SUS) is the responsibility of the National Committee for Health Technology Incorporation (CONITEC). A recent Cochrane systematic review demonstrated that intramuscular interferon beta 1a (IFN-β-1a-IM) was inferior to the other beta interferons (IFN-βs) for multiple sclerosis (MS). As a result, CONITEC commissioned an analysis to review possible disinvestment within SUS. The objective of this paper is to describe ...
Tópico(s): Parvovirus B19 Infection Studies
2017 - Adis, Springer Healthcare | PharmacoEconomics
Produção Nacional
Revisado por pares
Wallace Breno Barbosa, Juliana de Oliveira Costa, Lívia Lovato Pires de Lemos, Rosângela Maria Gomes, Helian Nunes de Oliveira, Cristina Mariano Ruas, Francisco de Assis Acúrcio, Corrado Barbui, Marion Bennie, Brian Godman, Augusto Afonso Guerra,
Schizophrenia is associated with significant economic burden. In Brazil, antipsychotic drugs and outpatient and hospital services are provided by the Brazilian National Health System (SUS) for patients with schizophrenia. However, few studies capture the cost of managing these patients within the Brazilian NHS. This is important to appraise different management approaches within universal healthcare systems.Our objective was to use real-world data to describe the costs associated with the treatment ...
Tópico(s): Mental Health Treatment and Access
2018 - Adis, Springer Healthcare | Applied Health Economics and Health Policy
Produção Nacional
Revisado por pares
Lívia Lovato Pires de Lemos, Mírian Carvalho de Souza, Daniela Pena Moreira, Paulo Henrique Ribeiro Fernandes Almeida, Brian Godman, Stéphane Verguet, Augusto Afonso Guerra, Mariângela Leal Cherchiglia,
Background Female breast cancer is the most common cancer in Latin American and Caribbean (LAC) countries and is the leading cause of cancer deaths. The high mortality-to-incidence ratio in the regions is associated with mainly the high proportion of advanced stage diagnosis, and also to inadequate access to health care. In this study we aimed to systematically review the proportion of advanced stage (III-IV) at diagnosis (pas) and the five-year stage-specific survival estimates of breast cancer in ...
Tópico(s): Advances in Oncology and Radiotherapy
2019 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Isabella Piassi Dias Godói, Túlio Tadeu Rocha Sarmento, Edna Afonso Reis, Ludmila Peres Gargano, Brian Godman, Francisco de Assis Acúrcio, Juliana Álvares-Teodoro, Augusto Afonso Guerra, Cristina Mariano Ruas,
The new coronavirus pandemic has appreciably impacted morbidity and mortality, as well as having an economic impact worldwide. New vaccines are a potential way forward to reduce transmission rates and subsequent infection. In Brazil, vaccines are being distributed via the public sector; however, in the future, they will be available in the private market. Information about consumers' willingness to pay (WTP) for a hypothetical vaccine against SARS CoV-2 can help future price setting discussions.A ...
Tópico(s): COVID-19 epidemiological studies
2021 - Taylor & Francis | Expert Review of Pharmacoeconomics & Outcomes Research
Ana Paula Valente, Ana Cristina Silva, E. Neves, Fábio C. L. Almeida, José Luís Cruz, Cláudia Camila Dias, Altamiro Costa‐Pereira, Alberto Caldas Afonso, António Guerra,
Undernutrition is an important cause of morbidity and mortality in infants and children worldwide. The aim of this study was to evaluate the nutritional status and their predictors in children from 0 to 5 years of age in São Tomé.A cross-sectional study was conducted in São Tomé Island.A total of 1285 individuals were enrolled between January and May 2011. Children were measured, and height for age (HAZ), weight for height (WHZ) and body mass index (BAZ) Z-score were computed. Global acute undernutrition ...
Tópico(s): Food Security and Health in Diverse Populations
2016 - Elsevier BV | Public Health
Produção Nacional
Revisado por pares
Jéssica Barreto Ribeiro dos Santos, Augusto Afonso Guerra, Michael Ruberson Ribeiro da Silva, Alessandra Maciel Almeida, Francisco de Assis Acúrcio, Juliana Álvares-Teodoro,
To evaluate the persistence of biological drugs used as the first line of biological treatment in patients diagnosed with rheumatoid arthritis. The predictors associated with persistence have also been verified.We evaluated a historical cohort composed of users of the Brazilian National Health System in the period between 2006 January and 2014 December. The endpoint was the medication persistence at 12 months.A population composed of 66,787 individuals started the first line of biological drug. ...
Tópico(s): Systemic Lupus Erythematosus Research
2019 - Taylor & Francis | Expert Review of Clinical Pharmacology
Produção Nacional
Rodrigo Gomes Silvestre Wallace Mateus Prata, Carolina Zampirolli Dias Anthony Martin, Augusto Afonso Guerra,
Background: The pharmaceutical sector undertakes extensive research and development (R&D). Pharmaceutical industries have continued to launch an appreciable number of new medicines, different pharmaceutical formulations, new indications and other innovations that contribute to the growth of this sector. New novel medicines are increasingly essential for continued success given the number of standard medicines now available as low cost generics or biosimilars. Consequently, innovation is a fundamental ...
Tópico(s): Biotechnology and Related Fields
2017 - | International Journal of Scientific Research and Management (IJSRM)
Produção Nacional
Revisado por pares
Letícia Farias Gerlack, Margô Gomes de Oliveira Karnikowski, Camila Alves Areda, Dayani Galato, Aline Gomes de Oliveira, Juliana Álvares Duarte Bonini Campos, Silvana Nair Leite, Ediná Alves Costa, Ione Aquemi Guibu, Orlando Mário Soeiro, Karen Sarmento Costa, Augusto Afonso Guerra, Francisco de Assis Acúrcio,
OBJECTIVE: To identify limiting factors in the management of pharmaceutical services in the primary health care provided by the Brazilian Unified Health System (SUS). METHODS: This study was based on the data from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil (PNAUM – National Survey on Access, Use and Promotion of Rational Use of Medicines), and it was conducted by interviews with professionals responsible for pharmaceutical services in Brazilian ...
Tópico(s): Pharmaceutical Economics and Policy
2017 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Produção Nacional
Revisado por pares
Celline Cardoso Almeida-Brasil, Juliana de Oliveira Costa, Viviane Celestino Ferreira dos Santos Aguiar, Daniela Pena Moreira, Edgar Nunes de Moraes, Francisco de Assis Acúrcio, Augusto Afonso Guerra, Juliana Álvares-Teodoro,
This study evaluated barriers to access to treatment for Alzheimer's disease based on administrative cases involving cholinesterase inhibitors (ChEIs) and submitted to the Minas Gerais State Health Secretariat in Brazil in 2012 and 2013. Drawing on data from 165 randomly selected cases, the study addressed the following dimensions of access: geographic accessibility, accommodation, acceptability, availability, and affordability. The administrative processing to supply ChEIs took an average of 39 ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2016 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Thais Moreira, Juliana Álvares-Teodoro, Mariana Michel Barbosa, Augusto Afonso Guerra, Francisco de Assis Acúrcio,
Inappropriate use and increase of health care spending reinforce the need to extend our knowledge about the quality of medication use.To describe and evaluate the profile of medication use in a representative sample of adult users of primary care services in the Unified Health System (SUS) of Minas Gerais.Cross-sectional study, with 1,159 interviewees in 104 municipalities and 253 health care services. Data on sociodemographic characteristics, health conditions and use of medicines were collected, ...
Tópico(s): Medication Adherence and Compliance
2020 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Revista Brasileira de Epidemiologia
Produção Nacional
Revisado por pares
Daniel Resende Faleiros, Juliana Álvares-Teodoro, Everton Nunes da Silva, Brian Godman, Ramon Gonçalves Pereira, Eli Iôla Gurgel Andrade, Francisco de Assis Acúrcio, Augusto Afonso Guerra,
Budget Impact Analyses (BIA) of medicines helps managers in promoting health systems' sustainability when assessing the role and value of new medicines. However, it is not clear whether BIAs typically underestimate or overestimate the impact on real-world budgets. This retroactive analysis seeks to compare estimated values obtained by a BIA and Real-World Evidence (RWE) to guide discussions.The estimated values were obtained through a BIA concerning the incorporation of adalimumab for the treatment ...
Tópico(s): Healthcare cost, quality, practices
2021 - Taylor & Francis | Expert Review of Pharmacoeconomics & Outcomes Research
Produção Nacional
Revisado por pares
Michael Ruberson Ribeiro da Silva, Jéssica Barreto Ribeiro dos Santos, Alessandra Maciel Almeida, Augusto Afonso Guerra, Juliana Álvares-Teodoro, Francisco de Assis Acúrcio,
Background: Biological therapies have a significant economic and clinical burden but, in general, lose their effectiveness over time. This study evaluated the medication persistence and costs associated to use of anti-TNF agents for psoriatic arthritis (PsA) treatment. Methods: A historical cohort composed of individuals in Brazil with PsA diagnosis was developed during the period between 2010 and 2015. The difference among the anti-TNF agents was verified by the log-rank test. The predictors of ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2019 - Taylor & Francis | Expert Review of Clinical Immunology
Produção Nacional
Revisado por pares
Roberto Lúcio Muniz Júnior, Isabella Piassi Dias Godói, Edna Afonso Reis, Marina Morgado Garcia, Augusto Afonso Guerra, Brian Godman, Cristina Mariano Ruas,
ABSTRACT Background: Zika virus is a newly emerging infection, associated with increasingly large outbreaks especially in tropical countries such as Brazil. A future Zika vaccine can contribute to decreasing the number of cases and associated complications. Information about consumers' willingness to pay (WTP) for a hypothetical Zika vaccine can help price setting discussions in the future in Brazil, starting with the private market.A cross-sectional study conducted among residents of Minas Gerais, ...
Tópico(s): COVID-19 epidemiological studies
2018 - Taylor & Francis | Expert Review of Pharmacoeconomics & Outcomes Research
Produção Nacional
Revisado por pares
Guilherme Nogueira Mill, Vladimir Santos da Costa, Natália D. Lima, Mariela Gabioux, Luiz Alexandre A. Guerra, Afonso M. Paiva,
In the present work, nine years of altimetry data are analyzed in combination with sea surface temperature and ocean color images in order to track Brazil Current eddies generated at Cape São Tomé, Brazil. Direct evidences are presented that at least six eddies detach from the main current during this period giving rise to isolated rings. Two rings move southward, bordering the current, while four migrate northward, and translate in the direction of the Tubarão Bight. These rings eventually reach ...
Tópico(s): Marine and fisheries research
2015 - Elsevier BV | Continental Shelf Research
Sam Alsford, Rachel B. Currier, José Afonso Guerra‐Assunção, Taane G. Clark, David Horn,
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause sleeping sickness in humans. T. b. brucei fails to infect humans because it is sensitive to innate immune complexes found in normal human serum known as trypanolytic factor (TLF) 1 and 2; the lytic component is apolipoprotein-L1 in both ...
Tópico(s): Lysosomal Storage Disorders Research
2014 - Public Library of Science | PLoS Pathogens
Produção Nacional
Revisado por pares
J F deS Barbosa, Selma Bruno, Novalyn Cruz, J S de Oliveira, João Afonso Ruaro, Ricardo Oliveira Guerra,
Objective To determine the relationship between perceived fatigability and oxygen consumption, carbon dioxide production, respiratory exchange ratio and the energy cost of walking in older women. Design Observational, cross-sectional study. Participants Forty-eight community-dwelling older women were recruited from senior centres in Natal, Rio Grande do Norte, Brazil. Main outcome measures Participants were evaluated in two different sessions. In the first session, sociodemographic and clinical ...
Tópico(s): Balance, Gait, and Falls Prevention
2015 - Elsevier BV | Physiotherapy