Lucas Paoli, Hans‐Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria A. Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom O. Delmont, Josep M. Gasol, Alvar D. Gossert, André Kahles, Matthew B. Sullivan, Patrick Wincker, Georg Zeller, Serina L. Robinson, Jörn Piel, Shinichi Sunagawa,
Natural microbial communities are phylogenetically and metabolically diverse. In addition to underexplored organismal groups1, this diversity encompasses a rich discovery potential for ecologically and biotechnologically relevant enzymes and biochemical compounds2,3. However, studying this diversity to identify genomic pathways for the synthesis of such compounds4 and assigning them to their respective hosts remains challenging. The biosynthetic potential of microorganisms in the open ocean remains ...
Tópico(s): Microbial Community Ecology and Physiology
2022 - Nature Portfolio | Nature
Tarun Mateti, Surabhi Aswath, Anoop Kishore Vatti, Agneya Kamath, Anindita Laha,
Drug delivery empowered with nanotechnology manifests to be a superior therapy to cancer. Electrospun nanofibers cocooning anti-cancerous drugs have shown tremendous cytotoxicity towards various tumor cells, including breast, brain, liver, and lung cancer cells. This pristine drug delivery system, according to literature, desists showing any undesirable effects on other parts of the body and bestows several other benefits. From nature-derived Curcumin to laboratory-made Doxorubicin, literature proclaims ...
Tópico(s): Electrohydrodynamics and Fluid Dynamics
2021 - Elsevier BV | Biotechnology Reports
Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel,
Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are multimodular megaenzymes that biosynthesize many bioactive natural products. They contain a remarkable range of domains and module types that introduce different substituents into growing polyketide chains. As one such modification, we recently reported Baeyer-Villiger-type oxygen insertion into nascent polyketide backbones, thereby generating malonyl thioester intermediates. In this work, genome mining focusing on architecturally ...
Tópico(s): Genomics and Phylogenetic Studies
2020 - Wiley | Angewandte Chemie International Edition
Agneya Bhushan, Peter J. Egli, Eike E. Peters, Michael F. Freeman, Jörn Piel,
The polytheonamides are among the most complex and biosynthetically distinctive natural products known to date. These potent peptide cytotoxins are derived from a ribosomal precursor processed by 49 mostly non-canonical posttranslational modifications. As the producer is a 'microbial dark matter' bacterium only distantly related to any cultivated organism, >70-step chemical syntheses have been developed to access these unique compounds. Here, we mined prokaryotic diversity to establish a synthetic ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2019 - Nature Portfolio | Nature Chemistry
Eric J. N. Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel,
Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most complex known enzymes from secondary metabolism and are responsible for the biosynthesis of highly diverse bioactive polyketides. However, most of these metabolites remain uncharacterized, since trans-AT PKSs frequently occur in poorly studied microbes and feature a remarkable array of non-canonical biosynthetic components with poorly understood functions. As a consequence, genome-guided natural product identification ...
Tópico(s): Fungal Biology and Applications
2019 - Nature Portfolio | Nature Chemical Biology
Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel,
Abstract The large number of sequenced bacterial genomes provides the opportunity to bioinformatically identify rich natural product sources among previously neglected microbial groups. Testing this discovery strategy, unusually high biosynthetic potential was suggested for the Oceanospirillales member Gynuella sunshinyii , a Gram‐negative marine bacterium from the rhizosphere of the halophilic plant Carex scabrifolia . Its genome contains numerous unusual biosynthetic gene clusters for diverse types ...
Tópico(s): Phytochemistry and Bioactive Compounds
2018 - Wiley | Angewandte Chemie International Edition
Agneya Bhushan, Eike E. Peters, Jörn Piel,
Marine sponges belong to the oldest animals existing today. Apart from their role in recycling of carbon and nitrogen in the ocean, they are also an important source of a wide variety of structurally diverse bioactive natural products. Over the past few decades, a multitude of compounds from sponges have been discovered exhibiting diverse, pharmacologically promising activities. However, in many cases the low substance quantities present in the sponge tissue would require the collection of large ...
Tópico(s): Synthetic Organic Chemistry Methods
2017 - Springer Science+Business Media | Progress in molecular and subcellular biology
Swagata Dilip Tavhare, K Nishteswar, VinayJ Shukla,
... recommendations, uşṃa vīrya drugs must be collected during āgneya ṃṛtu i.e. grīşṃa ṃṛtu. In present study, ...
Tópico(s): Heavy Metals in Plants
2016 - Medknow | Ancient Science of Life
Michael F. Freeman, Maximilian J. Helf, Agneya Bhushan, Brandon I. Morinaka, Jörn Piel,
Tópico(s): Legume Nitrogen Fixing Symbiosis
2016 - Nature Portfolio | Nature Chemistry
Agneya Kamath, Anindita Laha, Sudharsan Pandiyan, Surabhi Aswath, Anoop Kishore Vatti, Poulumi Dey,
Doxorubicin is cytotoxic anthracycline antibiotic drug used in cancer treatment. The drug’s efficacy in various kinds of cancer made its usage dominant for treating cancers. In this study, we determined the solubility of the doxorubicin in three different polymers, i.e., poly (N-isopropyl acrylamide), polyethylene glycol, and polyvinyl pyrrolidone, to increase the doxorubicin’s drug efficacy on the targeted tumor site. We investigated the doxorubicin-polymer interactions with carbon-nanotube in the ...
Tópico(s): Carbon Nanotubes in Composites
2021 - Elsevier BV | Journal of Molecular Liquids
Reiko Ueoka, Philipp Sondermann, Stefan Leopold‐Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R. Thomas Williamson, Erick M. Carreira, Jörn Piel,
Host-associated bacteria are increasingly being recognized as underexplored sources of bioactive natural products with unprecedented chemical scaffolds. A recently identified example is the plant-root-associated marine bacterium Gynuella sunshinyii of the chemically underexplored order Oceanospirillales. Its genome contains at least 22 biosynthetic gene clusters, suggesting a rich and mostly uncharacterized specialized metabolism. Here, in silico chemical prediction of a non-canonical polyketide ...
Tópico(s): Phytochemical compounds biological activities
2022 - Nature Portfolio | Nature Chemistry
Reiko Ueoka, Agneya Bhushan, Silke I. Probst, Walter M. Bray, R. Scott Lokey, Roger G. Linington, Jörn Piel,
Abstract The large number of sequenced bacterial genomes provides the opportunity to bioinformatically identify rich natural product sources among previously neglected microbial groups. Testing this discovery strategy, unusually high biosynthetic potential was suggested for the Oceanospirillales member Gynuella sunshinyii , a Gram‐negative marine bacterium from the rhizosphere of the halophilic plant Carex scabrifolia . Its genome contains numerous unusual biosynthetic gene clusters for diverse types ...
Tópico(s): Phytochemistry and Bioactive Compounds
2018 - Wiley | Angewandte Chemie
... is selected for the case study which has Agneya properties, Kapha Shamaka & Aacharya Kashyapa also quote it ...
Tópico(s): Pharmacological Effects of Medicinal Plants
2020 - | Journal of Ayurvedic and Herbal Medicine
Georg Steinert, Carla Huete Stauffer, Nele Aas-Valleriani, Erik Borchert, Agneya Bhushan, Alexandra H. Campbell, Maryam Chaib De Mares, Margarida Costa, Johanna Gutleben, Stephen Knobloch, Robert Gregory Lee, Stephanie Munroe, Deepak Naik, Eike E. Peters, Ellen Stokes, Wang WanLin, Eydís Einarsdóttir, Detmer Sipkema,
BluePharmTrain is a Marie Curie Initial Training Network of 17 European academic and industrial partners collaborating to train young scientists in multidisciplinary aspects of blue biotechnology. Harvesting marine sponges for the extraction of bioactive compounds is often highly unsustainable, and the chemical synthesis of promising compounds is often either too complex or very expensive. To find sustainable and economically feasible production methods of sponge-derived compounds, individual BluePharmTrain ...
Tópico(s): Aquaculture disease management and microbiota
2018 - Springer International Publishing | Grand challenges in biology and biotechnology
Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel,
... Reiko Ueoka Roy A. Meoded Alejandro Gran-Scheuch Agneya Bhushan Marco W. Fraaije Jörn Piel Volume 59Issue ... Scheuch, Search for more papers by this authorDr. Agneya Bhushan, Search for more papers by this authorProf. ... Scheuch, Search for more papers by this authorDr. Agneya Bhushan, Search for more papers by this authorProf. ...
Tópico(s): Biofuel production and bioconversion
2020 - Wiley | Angewandte Chemie International Edition
RK Niranjan, C. B. Rama Rao, Agneya Kumar Singh,
In this paper, a decision tree algorithm based on time-domain digital technique is developed for the identification and classification of diverse radar intra-pulse modulated signals for the electronic intelligence system in real-time. This includes linear frequency modulation, non-linear frequency modulation, stepped frequency modulation and bi-phase modulation. The received signal is digitised and the instantaneous phase and high accuracy instantaneous frequency are estimated. The instantaneous ...
Tópico(s): Radar Systems and Signal Processing
2021 - Defence Scientific Information and Documentation Centre | Defence Science Journal
Amit Chougule, Agneya Bhardwaj, Vinay Chamola, Pratik Narang,
Tópico(s): Visual Attention and Saliency Detection
2023 - Springer Science+Business Media | Cognitive Computation
D.P. Cogan, Agneya Bhushan, Reyvin M. Reyes, Lingyang Zhu, Jörn Piel, Satish K. Nair,
SignificanceThe channel-forming proteusins are bacterial helical peptides that allow permeation of positively charged ions to influence membrane potential and cellular physiology. We biochemically characterize the effect of two critical posttranslational modifications on the secondary structure of the peptide substrate. We determine how a methyl group can be added to the side chains of D-Asn residues in a peptide substrate and show how flanking residues influence selectivity. These studies should ...
Tópico(s): Epigenetics and DNA Methylation
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences
RK Niranjan, Agneya Kumar Singh, C. B. Rama Rao,
Radar identification is one of the vital operations in an electronic intelligence system. The conventional methods based on basic parameters comparison of unique identification of a radar in a cluster of similar radars, is prone to ambiguities. To meet the current tactical requirements of unique identification of a radar, the methodology needs to be based on better feature extraction, even in low SNR conditions. The paper explores a novel technique based on moving autocorrelation for the extraction ...
Tópico(s): Advanced SAR Imaging Techniques
2020 - Defence Scientific Information and Documentation Centre | Defence Science Journal
Athira Naduviledathu Raj, S T Asha, Shiny S Raj,
... balance in the Arthavavaha Srothas. Samsodhanam, use of Agneya Dravyas, use of Swayoni Vardhana dravyas, and avoidance ...
Tópico(s): Ovarian function and disorders
2022 - Mahadev Publications | International Journal of Ayurveda and Pharma Research
Ashok Kumar Panda, Rabinarayan Tripathy,
... disease process in Ayurveda. The normal snigdha-sheet- agneya character of Srotas get disturbed by the Vidahi & ...
Tópico(s): Inflammasome and immune disorders
2020 - | International Journal of Research -GRANTHAALAYAH
Ditikshakumari Ashokbhai Chaudhari, Kamlesh Hemantlal Bhogayata, Neha Parmar,
Tópico(s): Phytochemicals and Medicinal Plants
2020 - | Journal of Pharmaceutical and Scientific Innovation
Reiko Ueoka, Roy A. Meoded, Alejandro Gran‐Scheuch, Agneya Bhushan, Marco W. Fraaije, Jörn Piel,
... Reiko Ueoka Roy A. Meoded Alejandro Gran-Scheuch Agneya Bhushan Marco W. Fraaije Jörn Piel Volume 132Issue ... Scheuch, Search for more papers by this authorDr. Agneya Bhushan, Search for more papers by this authorProf. ... Scheuch, Search for more papers by this authorDr. Agneya Bhushan, Search for more papers by this authorProf. ...
Tópico(s): Enzyme Catalysis and Immobilization
2020 - Wiley | Angewandte Chemie
Pallavi K. Chavan, Priyanka Rawal, Sunita Shirguppi,
... to Marga Avrodha of the Artavavaha Stratos. Using Agneya Dravyas relieves the Kapha, which does Avarana to ... of Artava. Hence, Venu Shatapushpa Kashaya Krushnatila Kashaya, Agneya, Pitta Vardhaka, and Vata Kapha Shamaka were selected ...
Tópico(s): Acupuncture Treatment Research Studies
2024 - | International Ayurvedic Medical Journal
Agneya A. Kerure, Jason Freeman,
Tópico(s): Music Technology and Sound Studies
2018 - Audio Engineering Society | Journal of the Audio Engineering Society
... all the Dravyas are categorized as Parthiva, Jaleeya, Agneya, Vayaveeya and Akasheeya. As per Sushruta, Prakruti is ...
Tópico(s): Complementary and Alternative Medicine Studies
2025 - | Journal of Ayurveda and Integrated Medical Sciences
Nikita Bharghava, Bihani Sanjyal, K. Bharathi, Poonam Choudhary,
... of Artavkshaya, managed through principles like use of Agneya dravya, Agni Deepana, Vata Shamana and Piita Vardhna. ...
Tópico(s): Pharmacological Effects of Medicinal Plants
2024 - Mahadev Publications | International Journal of Ayurveda and Pharma Research
Mitali Verma, Urmila Shukla, Kirti Sisodiya, Shreya Sahu,
... under mainly 4 groups i.e., Vayavya Keeta, Agneya Keeta, Saumya Keeta, Sannipataka Keeta. viz, one each ...
Tópico(s): Venomous Animal Envenomation and Studies
2024 - | Journal of Ayurveda and Integrated Medical Sciences
A. Nandi, Taiyeba Tahira, Sukumar Ghosh,
... rodha (blockage of channels), resulting in Vata vaigunya. Agneya property of pitta depleted. Here is a case ...
Tópico(s): Pharmacology and Obesity Treatment
2024 - | International Ayurvedic Medical Journal
Stuti Rawat, Uttam Sharma, G.M Kavya, Bhanupriya Kaushik, Abhishek Saxena,
... consider it as Updhatu of Rakta. Artava is Agneya and has characteristics similar to Rakta. According to ...
Tópico(s): Phytochemistry and Bioactive Compounds
2024 - | International Ayurvedic Medical Journal