J Groen, Katja Ritz, Daan C. Velseboer, M. Aramideh, Jacobus J. van Hilten, Agnita J.W. Boon, Bart P. van de Warrenburg, Frank Baas, Marina A.J. Tijssen,
... more papers by this authorAgnita J.W. Boon, Agnita J.W. Boon Department of Neurology, Erasmus MC ... more papers by this authorAgnita J.W. Boon, Agnita J.W. Boon Department of Neurology, Erasmus MC ...
Tópico(s): Nerve injury and regeneration
2012 - Wiley | Movement Disorders
David G. Mann, Norico Yamada, John J. Bolton, Andrzej Witkowski, Rosa Trobajo,
... allowing comparison with similar Nitzschia species, particularly N. agnita and N. kuetzingioides, examined from type material. We ... therefore described as N. captiva sp. nov. Nitzschia agnita and N. kuetzingioides, on the other hand, are conspecific and N. agnita has priority. Nitzschia captiva and N. agnita are extremely similar in valve shape, dimensions, pattern ... can be separated by their girdle structure. Nitzschia agnita appears to be a freshwater species, though somewhat ... for finding and sending type material of N. agnita and N. kuetzingioides from the Hustedt Collection (Alfred ...
Tópico(s): Microbial Community Ecology and Physiology
2023 - Taylor & Francis | Phycologia
Produção Nacional
Revisado por pares
Marialuisa Quadri, Wim Mandemakers, Martyna M. Grochowska, Roy Masius, Hanneke Geut, Edito Fabrizio, Guido J. Breedveld, Demy J.S. Kuipers, Michelle Minneboo, Leonie J.M. Vergouw, Ana Carreras Mascaro, Ekaterina Yonova-Doing, Erik Simons, Tianna Zhao, Alessio Di Fonzo, Hsiu‐Chen Chang, Piero Parchi, Marta Melis, Leonor Correia Guedes, Chiara Criscuolo, Astrid Thomas, Rutger W. W. Brouwer, Daphne Heijsman, Angela Ingrassia, Giovanna Calandra‐Buonaura, Janneke P.A Rood, Sabina Capellari, Annemieke J.M. Rozemüller, Marianna Sarchioto, Hsin Fen Chien, Nicola Vanacore, Simone Olgiati, Yah-Huei Wu-Chou, Tu‐Hsueh Yeh, Agnita J.W. Boon, Susanne E. Hoogers, Mehrnaz Ghazvini, Arne IJpma, Wilfred F. J. van IJcken, Marco Onofrj, Paolo Barone, David Nicholl, Andreas Puschmann, Michele De Mari, Anneke J.A. Kievit, Egberto Reis Barbosa, Giuseppe De Michele, Daniëlle Majoor‐Krakauer, John C. van Swieten, Frank Jan de Jong, Joaquim J. Ferreira, Giovanni Cossu, Chin‐Song Lu, G. Meco, Pietro Cortelli, Wilma D.J. van de Berg, Vincenzo Bonifati, Vincenzo Bonifati, Marialuisa Quadri, Wim Mandemakers, Anneke J.A. Kievit, Agnita J.W. Boon, Janneke P.A Rood, Leonie J.M. Vergouw, Frank Jan de Jong, John C. van Swieten, Francesco Mattace‐Raso, Klaus L. Leenders, Joaquim J. Ferreira, Leonor Correia Guedes, Andreas Puschmann, Emil Ygland, Christer Nilsson, Hsin Fen Chien, Egberto Reis Barbosa, Laura Bannach Jardim, Carlos Roberto de Mello Rieder, Hsiu‐Chen Chang, Chin‐Song Lu, Yah-Huei Wu-Chou, Tu‐Hsueh Yeh, Leonardo Lopiano, Cristina Tassorelli, C. Pacchetti, Giulio Riboldazzi, Giorgio Bono, Cristoforo Comi, Alessandro Padovani, Barbara Borroni, Francesco Raudino, E. Fincati, Michèle Tinazzi, A. Bonizzato, C Ferracci, A. Dalla Libera, Giovanni Abbruzzese, Pietro Cortelli, Sabina Capellari, Roberto Marconi, Marco Guidi, Marco Onofrj, Astrid Thomas, Nicola Vanacore, G. Meco, Edito Fabrizio, Giovanni Fabbrini, Alfredo Berardelli, Fabrizio Stocchi, Laura Vacca, Paolo Barone, Marina Picillo, Giuseppe De Michele, Chiara Criscuolo, Michele De Mari, Claudia Dell’Aquila, Gianni Iliceto, Vincenzo Toni, Giorgio Trianni, Monica Gagliardi, Grazia Annesi, Aldo Quattrone, Valeria Saddi, Gianni Cossu, Maurizio Melis,
BackgroundMost patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders.MethodsOur study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherited Parkinson's disease to identify the disease locus. Second, we sequenced the candidate gene in an international ...
Tópico(s): Neurological diseases and metabolism
2018 - Elsevier BV | The Lancet Neurology
Elena P. Ivanova, Natalia V. Zhukova, Anatoly M. Lysenko, Nataliya M. Gorshkova, Alexander F. Sergeev, Valery V. Mikhailov, John P. Bowman,
... chemotaxonomic and phylogenetic investigation, two novel species, Loktanella agnita sp. nov. and Loktanella rosea sp. nov., are ...
Tópico(s): Identification and Quantification in Food
2005 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Jan Klimaszewski, Georges Pelletier,
... Canada: British Columbia). The first record of Neoisoglossa agnita (Casey) in Alberta is provided. Two nominal species, ... repensa Casey (= Neoisoglossa ), Isoglossa arcuata Casey (= Neoisoglossa ), Ocalea agnita Casey (= Neoisoglossa ), Ocalea franciscana Casey (= Neoisoglossa ), Ocalea fusca ...
Tópico(s): Fossil Insects in Amber
2004 - Cambridge University Press | The Canadian Entomologist
Miriam Michael Stimson, Mary Agnita Reuter,
... and Thymine Desoxyriboside1,2Miriam Michael Stimson and Mary Agnita ReuterCite this: J. Am. Chem. Soc. 1945, 67, ...
Tópico(s): Estrogen and related hormone effects
1945 - American Chemical Society | Journal of the American Chemical Society
Miriam Michael Stimson, Mary Agnita Reuter,
... Cytosine and Isocytosine1,2Miriam Michael Stimson and Mary Agnita ReuterCite this: J. Am. Chem. Soc. 1945, 67, ...
Tópico(s): DNA and Nucleic Acid Chemistry
1945 - American Chemical Society | Journal of the American Chemical Society
Miriam Michael Stimson, Mary Agnita Reuter,
... and Uric Acid1Miriam Michael Stimson Sr. and Mary Agnita Reuter Sr.Cite this: J. Am. Chem. Soc. ...
Tópico(s): Fluorine in Organic Chemistry
1943 - American Chemical Society | Journal of the American Chemical Society
Miriam Michael Stimson, Mary Agnita Reuter,
... of Methoxy-cinchona Alkaloids1Miriam Michael Stimson and Mary Agnita ReuterCite this: J. Am. Chem. Soc. 1946, 68, ...
Tópico(s): Chemical synthesis and alkaloids
1946 - American Chemical Society | Journal of the American Chemical Society
Sister Miriam Michael Stimson, Sister Mary Agnita Reuter,
... and PyrimidinesSister Miriam Michael Stimson and Sister Mary Agnita ReuterCite this: J. Am. Chem. Soc. 1941, 63, ...
Tópico(s): Analytical chemistry methods development
1941 - American Chemical Society | Journal of the American Chemical Society
Produção Nacional
Revisado por pares
Eva‐Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, F. Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Brüggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alícia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine N. Clark, E. Yu. Fedotova, Natalya Abramycheva, Victoria Álvarez, Manuel Menéndez‐González, S. Jesús Maestre, Pilar Gómez‐Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin‐Hsien Lin, Ming‐Che Kuo, David Crosiers, Zbigniew K. Wszołek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimón, Caroline H. Williams‐Gray, Marta Camacho, Mario Cornejo‐Olivas, Luis Torres-Ramírez, Yih‐Ru Wu, Guey‐Jen Lee‐Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbäumer, Andrea A. Kühn, Friederike Borngräber, Giuseppe De Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce A. Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen‐Yang Lim, Azlina Ahmad‐Annuar, Ai Huey Tan, Bashayer Al‐Mubarak, Haşmet Hanağası, Dariusz Koziorowski, Sibel Ertan, Gençer Genç, Patrícia de Carvalho Aguiar, Melinda Barkhuizen, Márcia Mattos Gonçalves Pimentel, Rachel Saunders‐Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel‐Cresswell, Anthony E. Lang, Matěj Škorvánek, Agnita J.W. Boon, Rejko Krüger, Esther Sammler, Vítor Tumas, Baorong Zhang, Gaëtan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng‐King Tan, Joana Damásio, Péter Klivényi, Vladimir Kostić, David Arkadir, Mika H. Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Rieß, Parimal Das, Brit Mollenhauer, Emilia Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey‐Meei Wu, С. Н. Иллариошкин, Enza Maria Valente, Jan Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean‐Christophe Corvol, Christine Klein,
Abstract Background As gene‐targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial‐ready cohorts is limited. Objective The objectives are to (1) establish an international cohort of affected and unaffected ...
Tópico(s): Nuclear Receptors and Signaling
2023 - Wiley | Movement Disorders
Agnita Siska Pramasdyahsari, Rina Dwi Setyawati, Sindi Nur Aini, Ukima Nusuki, Julia Puspita Arum, Iin Dwi Astutik, Wahyu Widodo, Nafiatuz Zuliah, Ummy Salmah,
21st-century learning requires students to have the competency problem-solving and critical thinking, creative thinking, collaboration and communication. However, the mathematical critical thinking skills of Indonesian junior high school students remain relatively low. Therefore, the study aims to develop a digital book STEM PjBL to foster the students’ mathematical critical thinking skills. To achieve this aim development and research of the Borg and Gall (Gall et al., 2007) model continued with ...
Tópico(s): STEM Education
2023 - Modestum Limited | Eurasia Journal of Mathematics Science and Technology Education
George Lee, Anita Chang, Agnita Pal, Thu-An Tran, Xinyue Cui, Thu Quach,
During the pandemic, Asian Health Services (AHS), a federally qualified health center serving patients in 14 Asian languages, transformed rapidly to provide telehealth visits, developed an intensive remote patient monitoring program, and conducted a digital health literacy survey.This article describes how AHS collected and utilized descriptive data on our patient population to inform our rapid adoption of telehealth and assess our patients' response to these changes.Our experiences show that audio ...
Tópico(s): Mobile Health and mHealth Applications
2022 - Mary Ann Liebert, Inc. | Health Equity
Felix Gövert, Ligia Abrante, Jos S. Becktepe, Bettina Balint, Christos Ganos, Ulrich Hofstadt‐van Oy, Christos Krogias, James Varley, Sarosh R. Irani, Sofija Paneva, Maarten J. Titulaer, Juna M. de Vries, Agnita J.W. Boon, Marco W.J. Schreurs, Bastien Joubert, Jérôme Honnorat, Alberto Vogrig, Helena Ariño, Lídia Sabater, Josep Dalmau, Sangeeta Scotton, Saiju Jacob, Nico Melzer, Christian G. Bien, Christian Geis, Jan Lewerenz, Harald Prüß, Klaus-Peter Wandinger, Günther Deuschl, Frank Leypoldt,
Autoimmune encephalitis can be classified into antibody-defined subtypes, which can manifest with immunotherapy-responsive movement disorders sometimes mimicking non-inflammatory aetiologies. In the elderly, anti-LGI1 and contactin associated protein like 2 (CASPR2) antibody-associated diseases compose a relevant fraction of autoimmune encephalitis. Patients with LGI1 autoantibodies are known to present with limbic encephalitis and additionally faciobrachial dystonic seizures may occur. However, ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - Oxford University Press | Brain
Martyna M. Grochowska, Ana Carreras Mascaro, Valerie Boumeester, Domenico Natale, Guido J. Breedveld, Hanneke Geut, Wiggert A. van Cappellen, Agnita J.W. Boon, Anneke J.A. Kievit, Esther Sammler, Piero Parchi, Pietro Cortelli, Dario R. Alessi, Wilma D.J. van de Berg, Vincenzo Bonifati, Wim Mandemakers,
Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10) gene have been associated with autosomal-dominant Parkinson's disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, LRP10 variants have been found in individuals diagnosed with progressive supranuclear palsy and amyotrophic lateral sclerosis. Despite this genetic evidence, little is known about the expression and function of LRP10 protein in the human brain under physiological or pathological ...
Tópico(s): Neurological disorders and treatments
2021 - Springer Science+Business Media | Acta Neuropathologica
Christina Fevga, Yangshin Park, Ebba Lohmann, Anneke J.A. Kievit, Guido J. Breedveld, Federico Ferraro, Leon de Boer, Rick van Minkelen, Haşmet Hanağası, Agnita J.W. Boon, Wei Wang, Gregory A. Petsko, Quyen Q. Hoang, Murat Emre, Vincenzo Bonifati,
Missense variants and multiplications of the alpha-synuclein gene (SNCA) are established as rare causes of autosomal dominant forms of Parkinson's Disease (PD).Two families of Turkish origins with PD were studied; the SNCA coding region was analyzed by Sanger sequencing, and by whole exome sequencing (WES) in the index patient of the first and the second family, respectively. Co-segregation studies and haplotype analysis across the SNCA locus were carried out. Functional studies included in vitro thioflavin- ...
Tópico(s): Neurological disorders and treatments
2021 - Elsevier BV | Parkinsonism & Related Disorders
Amaia Muñoz‐Lopetegi, Marienke A.A.M. de Bruijn, Sanae Boukhrissi, Anna E.M. Bastiaansen, Mariska M.P. Nagtzaam, Esther Hulsenboom, Agnita J.W. Boon, Rinze F. Neuteboom, Juna M. de Vries, Peter A.E. Sillevis Smitt, Marco W.J. Schreurs, Maarten J. Titulaer,
Objective Antibodies against glutamic acid decarboxylase 65 (anti-GAD65) are associated with a number of neurologic syndromes. However, their pathogenic role is controversial. Our objective was to describe clinical and paraclinical characteristics of anti-GAD65 patients and analyze their response to immunotherapy. Methods Retrospectively, we studied patients (n = 56) with positive anti-GAD65 and any neurologic symptom. We tested serum and CSF with ELISA, immunohistochemistry, and cell-based assay. Accordingly, ...
Tópico(s): Peripheral Neuropathies and Disorders
2020 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation
Jonas M. den Heijer, Valerie Cullen, Marialuisa Quadri, Arnoud Schmitz, Dana Hilt, Peter T. Lansbury, Henk W. Berendse, Wilma D.J. van de Berg, Rob M.A. de Bie, Jeffrey M. Boertien, Agnita J.W. Boon, Maria Fiorella Contarino, Jacobus J. van Hilten, Jorrit I. Hoff, Tom van Mierlo, Alex G. Munts, Anne A. van der Plas, Mirthe M. Ponsen, Frank Baas, Daniëlle Majoor‐Krakauer, Vincenzo Bonifati, Teus van Laar, Geert Jan Groeneveld,
Abstract Background The most common genetic risk factor for Parkinson's disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single population. The objective of this study was to assess the entire GBA1 gene in Parkinson's disease from a single large population. Methods The GBA1 gene was assessed in 3402 Dutch Parkinson's disease patients using next‐generation sequencing. Frequencies were compared with Dutch controls (n = 655). Family ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2020 - Wiley | Movement Disorders
Lena H.P. Vroegindeweij, Agnita J.W. Boon, J. H. P. Wilson, Janneke G. Langendonk,
Abstract Background Aceruloplasminemia is a rare genetic iron overload disorder, characterized by progressive neurological manifestations. The effects of iron chelation on neurological outcomes have only been described in case studies, and are inconsistent. Aggregated case reports were analyzed to help delineate the disease-modifying potential of treatment. Methods Data on clinical manifestations, treatment and neurological outcomes of treatment were collected from three neurologically symptomatic ...
Tópico(s): Trace Elements in Health
2020 - BioMed Central | Orphanet Journal of Rare Diseases
Lisanne J. Dommershuijsen, Sirwan K.L. Darweesh, Annemarie I. Luik, Brenda C.T. Kieboom, Peter J. Koudstaal, Agnita J.W. Boon, M. Arfan Ikram, M. Kamran Ikram, Eline M. Bunnik,
ABSTRACT Clinical studies have shown that up to 90% of patients with idiopathic rapid eye movement sleep behavior disorder (RBD) will eventually be diagnosed with a clinical α‐synucleinopathy. Because of this high conversion rate, screening for RBD is often performed to identify eligible participants for studies aimed at elucidating the prodromal phase of α‐synucleinopathies. However, screening for RBD, especially in the general population, raises many ethical dilemmas. In light of the existing ethical ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2020 - Wiley | Movement Disorders
Rongmin Chen, Hana Park, Nelli Mnatsakanyan, Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Zeyu Tang, Agnita J.W. Boon, Giovanni Cossu, Wim Mandemakers, Vincenzo Bonifati, Peter J. Smith, Kambiz N. Alavian, Elizabeth A. Jonas,
Abstract Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F 1 F O ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial uncoupling and enhanced ATP production efficiency while in contrast mutations in DJ-1 or DJ-1 knockout increased mitochondrial uncoupling, and depolarized neuronal mitochondria. In mesencephalic DJ-1 KO cultures, there was a progressive loss of neuronal process extension. ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2019 - Springer Nature | Cell Death and Disease
Christine M.E. Rustenburg, Sayf S. A. Faraj, Roderick M. Holewijn, Idsart Kingma, Barend J. van Royen, Agnita Stadhouder, Kaj S. Emanuel,
OBJECTIVEDegenerative lumbar scoliosis, or de novo degenerative lumbar scoliosis, can result in spinal canal stenosis, which is often accompanied by disabling symptoms. When surgically treated, a single-level laminectomy is performed and short-segment posterior instrumentation is placed to restore stability. However, the effects of laminectomy on spinal stability and the necessity of placing posterior instrumentation are unknown. Therefore, the aim of this study was to assess the stability of lumbar ...
Tópico(s): Spinal Fractures and Fixation Techniques
2019 - American Association of Neurological Surgeons | Neurosurgical FOCUS
Johannes Kiefer, Alexander Stärk, Agnita Kiefer, Heike Glade,
The deposition of insoluble inorganic substances on heat exchanger surfaces has a strong negative influence on the heat transfer and thus on the performance of the apparatus and the process. The analysis of the deposits is a crucial step towards the development of suitable technologies for scaling mitigation and prevention. Such analysis, however, is challenging and often requires advanced instrumentation and sample preparation. To overcome this problem, we present a straightforward analytical approach ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2018 - Multidisciplinary Digital Publishing Institute | Energies
Laura Donker Kaat, Lieke Meeter, Wan Zheng Chiu, Shami Melhem, Agnita J.W. Boon, Kaj Blennow, Henrik Zetterberg, John C. van Swieten,
Abstract Introduction Neurofilament light chain (NfL) is a promising biomarker in neurodegenerative diseases. Elevated NfL levels in CSF and blood have been observed in a growing number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease. We studied serum NfL levels in patients with progressive supranuclear palsy (PSP) in relation to disease severity and survival. Methods Serum NfL levels were determined cross-sectionally in a retrospective cohort of 131 patients with ...
Tópico(s): Neurological diseases and metabolism
2018 - Elsevier BV | Parkinsonism & Related Disorders
Paula Valerie ter Wengel, Ricardo E. Feller, Agnita Stadhouder, Dagmar Verbaan, F. Cumhur Öner, J. Carel Goslings, W. Peter Vandertop,
The optimal surgical timeframe for neurological recovery in traumatic spinal cord injury (tSCI) still remains unknown. Recent guidelines have recommended performing surgery within 24 h for all patients with tSCI regardless of initial neurological deficit. It remains unclear whether patients with complete, incomplete tSCI, or traumatic central cord injury (TCCI) will experience the same degree of improvement after urgent surgical intervention. We investigated if the severity of initial neurological ...
Tópico(s): Spinal Dysraphism and Malformations
2018 - Springer Science+Business Media | European Spine Journal
E. Agnita Sharon, Kanayairam Velayutham, R. Ramanibai,
Tópico(s): Diverse Scientific Research Studies
2018 - | SSR Institute of International Journal of Life Sciences
Lars P. den Ouden, Arjen J. Smits, Agnita Stadhouder, Ricardo E. Feller, Jaap Deunk, Frank W. Bloemers,
Study Design. Retrospective epidemiological study. Objective. To describe the epidemiology of spinal fractures over a 10 years period in a level one trauma center in the Netherlands. Summary of Background Data. Spinal fractures may have large socioeconomic consequences. The prevalence and outcomes likely change over the years owing to improved traffic safety, increasing population age and improved medical treatment. This is the first study to address the epidemiology of spinal fractures over a large ...
Tópico(s): Hip and Femur Fractures
2018 - Lippincott Williams & Wilkins | Spine
Evelien Zoons, Jan Booij, Cathérine C.S. Delnooz, Joke M. Dijk, Yasmine E. M. Dreissen, J.H.T.M. Koelman, Sandra Salm, Matěj Škorvánek, Marenka Smit, M. Aramideh, H.M.E. Bienfait, Agnita J.W. Boon, J. W. M. Brans, Edo M Hoogerwaard, A. Hovestadt, D.J. Kamphuis, Alexander G. Munts, Johannes D. Speelman, Marina A.J. Tijssen,
Objective Trials for additional or alternative treatments for cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed the first trial to investigate whether dystonic jerks/tremor in patients with CD respond to the selective serotonin reuptake inhibitor (SSRI) escitalopram. Methods In a randomised, double-blind, crossover trial, patients with CD received escitalopram and placebo for 6 weeks. Treatment with BoNT was continued, and scores on rating scales ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2018 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Eva Jacobs, Barend J. van Royen, Sander M. J. van Kuijk, Johannes Merk, Agnita Stadhouder, Lodewijk W. van Rhijn, Paul Willems,
Surgery for adult spinal deformity is a challenging and complex procedure with high reported complication (8.4%-42%) and revision rates (9%-17.6%). Failure to achieve or maintain adequate postoperative sagittal alignment has been reported to be the main cause of mechanical complications. In order to define appropriate surgical targets, the Scoliosis Research Society-Schwab classification and the Global Alignment and Proportion (GAP) score were established. In the literature, no study has yet compared ...
Tópico(s): Spine and Intervertebral Disc Pathology
2018 - Elsevier BV | The Spine Journal
Roderick M. Holewijn, Marinus de Kleuver, Albert J. van der Veen, Kaj S. Emanuel, Arno Bisschop, Agnita Stadhouder, Barend J. van Royen, Idsart Kingma,
Biomechanical study.Recently, a posterior concave periapical distraction device for fusionless scoliosis correction was introduced. The goal of this study was to quantify the effect of the periapical distraction device on spinal range of motion (ROM) in comparison with traditional rigid pedicle screw-rod instrumentation.Using a spinal motion simulator, 6 human spines were loaded with 4 N m and 6 porcine spines with 2 N m to induce flexion-extension (FE), lateral bending (LB), and axial rotation (AR). ...
Tópico(s): Spine and Intervertebral Disc Pathology
2017 - SAGE Publishing | Global Spine Journal