Ivï¿ ⁄ n Delgado‐Enciso, Violeta M. Madrigal-Pérez, Agustín Lara‐Esqueda, Martha Diaz-Sanchez, José Guzmán-Esquivel, Luis Rosas-Vizcaino, Oscar Virgen-Jimenez, Juleny Kleiman-Trujillo, Maria Lagarda-Canales, Gabriel Ceja-Espíritu, Viridiana Rangel-Salgado, Uriel A. López-Lemus, Josuel Delgado‐Enciso, Agustin ï¿ ⁄ Lara-Basulto, Alejandro Soriano Hernï¿ ⁄ ndez,
Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing ...
Tópico(s): Pressure Ulcer Prevention and Management
2018 - Spandidos Publishing | Biomedical Reports
Martı́n Rosas, Fause Attié, Gustavo Pastelı́n, Agustín Lara, Oscar Velazquez, Roberto Tapia‐Conyer, Jesús Martínez-Réding, Arturo J. Méndez, Antonio Lorenzo-Negrete, Jaime Herrera-Acosta,
Martin Rosas, Fause Attie, Gustavo Pastelin, Agustin Lara, Oscar Velazquez, Roberto Tapia-conyer, Jesus Martinez-reding, Arturo mendez, Antonio Lorenzo-negrete, and Jaime Herrera-acosta: Prevalence of proteinuria in Mexico: ...
Tópico(s): Blood Pressure and Hypertension Studies
2005 - Elsevier BV | Kidney International
Rafael Violante-Ortíz, Blanca E. Del-Río-Navarro, Agustín Lara‐Esqueda, Pedro Pérez, Guillermo Fanghänel, Agustín Madero, Arturo Berber,
Tópico(s): Obesity, Physical Activity, Diet
2005 - Adis, Springer Healthcare | Advances in Therapy
Agustín Lara, Vicente Mayor, Rafael Estepa, Antonio Estepa, Jesús E. Dı́az-Verdejo,
The complexity and diversity of the technologies involved in the Internet of Things (IoT) challenge the generalization of security solutions based on anomaly detection, which should fit the particularities of each context and deployment and allow for performance comparison. In this work, we provide a flexible architecture based on building blocks suited for detecting anomalies in the network traffic and the application-layer data exchanged by IoT devices in the context of Smart Home. Following this ...
Tópico(s): Smart Grid Security and Resilience
2023 - Elsevier BV | Internet of Things
David Elorriaga, Felipe de la Cruz‐Martínez, María J. Rodríguez‐Álvarez, Agustín Lara‐Sánchez, José A. Castro‐Osma, Joaquín García‐Álvarez,
Abstract Fast addition of highly polar organometallic reagents (RMgX/RLi) to cyclic carbonates (derived from CO 2 as a sustainable C1 synthon) has been studied in 2‐methyltetrahydrofuran as a green reaction medium or in the absence of external volatile organic solvents, at room temperature, and in the presence of air/moisture. These reaction conditions are generally forbidden with these highly reactive main‐group organometallic compounds. The correct stoichiometry and nature of the polar organometallic ...
Tópico(s): Catalysis for Biomass Conversion
2021 - Wiley | ChemSusChem
Jessica C. Romero-Michel, Karen A Mokay-Ramírez, Marina Delgado‐Machuca, Josuel Delgado‐Enciso, Nomely S. Aurelien-Cabezas, Daniel Tiburcio‐Jimenez, Carmen Meza‐Robles, Osiris G. Delgado‐Enciso, José Guzmán-Esquivel, Sergio A Zaizar-Fregoso, Margarita L Martinez Fierro, Iram Pablo Rodríguez Sánchez, Valery Melnikov, Carlos E Barajas-Saucedo, Agustín Lara‐Esqueda, Iván Delgado‐Enciso,
Introduction: COVID-19 pandemic affects human health and the global economy. Its evolution is unpredictable, making it hard for governments to provide response actions suited for all populations. Meanwhile, informal street workers carry on with their labor despite contingency measures to sustain their lives. The objective was to conduct a case-control study to become aware of how street vendors' economy is affected during the COVID-19 pandemic. Methodology: During phase 2 of the COVID-19 pandemic ...
Tópico(s): COVID-19 Pandemic Impacts
2021 - Open Learning on Enteric Pathogens | The Journal of Infection in Developing Countries
Javier Martı́nez, Felipe de la Cruz‐Martínez, Marc Martínez de Sarasa Buchaca, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Michael North, José A. Castro‐Osma, Agustín Lara‐Sánchez,
Abstract Bio‐derived furan‐ and diacid‐derived cyclic carbonates have been synthesized in high yields from terminal epoxides and CO 2 . Furthermore, four highly substituted terpene‐derived cyclic carbonates were isolated in good yields with excellent diastereoselectivity in some cases. Eleven new cyclic carbonates derived from 10‐undecenoic acid under mild reaction conditions were prepared, providing the corresponding carbonate products in excellent yields. The catalyst system also performed the conversion ...
Tópico(s): Chemical Synthesis and Reactions
2021 - Wiley | ChemPlusChem
Javier Martı́nez, Felipe de la Cruz‐Martínez, Marc Martínez de Sarasa Buchaca, María P. Caballero, Rosa M. Ojeda‐Amador, María Desamparados Salvador, Giuseppe Fregapane, Juan Tejeda, José A. Castro‐Osma, Agustín Lara‐Sánchez,
Highly efficient and metal-free bifunctional organocatalysts have been used for the synthesis of waste vegetable oils-derived cyclic carbonates from bio-derived epoxides and CO2. In this contribution, epoxides 2a-k and carbon dioxide have been used as renewable feedstocks for the synthesis of cyclic carbonates 5a-k in excellent isolated yields (85–97%) using the highly efficient and metal-free bifunctional imidazole-based organocatalyst 4b under solvent-free conditions. The preparation of cyclic ...
Tópico(s): biodegradable polymer synthesis and properties
2021 - Elsevier BV | Journal of environmental chemical engineering
Enrique Niza, Matěj Božík, Iván Bravo, Pilar Clemente-Casares, Agustín Lara‐Sánchez, Alberto Juan, Pavel Klouček, Carlos Alonso‐Moreno,
Carvacrol (CAR) is a natural bioactive compound with antioxidant and antimicrobial activity that is present in essential oils. The application of CAR in food preservation is hampered by its high volatility, low solubility in water, and susceptibility to light, heat and oxygen degradation. Polylactide (PLA) is an FDA-approved polymer derived from renewable resources. Controlled release of CAR from PLA nanoparticles (NPs) could improve its antimicrobial efficacy and storage. In this study, negatively ...
Tópico(s): Medicinal Plants and Neuroprotection
2020 - Elsevier BV | Food Chemistry
Marta Navarro, Luis F. Sánchez‐Barba, Andrés Garcés, Juan Fernández‐Baeza, Israel Fernández, Agustín Lara‐Sánchez, Ana M. Rodrı́guez,
The binuclear aluminum complexes [AlR 2 (κ 2 - NN ′;κ 2 - NN ′)AlR 2 ] with TBAB/PPNCl behave as excellent systems for cyclic carbonate formation from CO 2 with challenging epoxides.
Tópico(s): Chemical Synthesis and Reactions
2020 - Royal Society of Chemistry | Catalysis Science & Technology
Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Agustín Lara‐Sánchez, Sonia Sobrino, Jaime Martínez‐Ferrer, Andrés Garcés, Marta Navarro, Ana M. Rodrı́guez,
Two new derivatives of the bis(3,5-dimethylpyrazol-1-yl)methane modified by introduction of organosilyl groups on the central carbon atom, one of which bearing a chiral fragment, have been easily prepared. We verified the potential utility of these compounds through the reaction with [Zr(NMe2)4] for the preparation of novel zirconium complexes in which an ancillary bis(pyrazol-1-yl)methanide acts as a robust monoanionic tridentate scorpionate in a κ3-NNC chelating mode, forming strained four-membered ...
Tópico(s): Chemical Synthesis and Reactions
2020 - American Chemical Society | Inorganic Chemistry
Francisco J. Cimas, Enrique Niza, Alberto Juan, María del Mar Noblejas‐López, Iván Bravo, Agustín Lara‐Sánchez, Carlos Alonso‐Moreno, Alberto Ocaña,
Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation through the ubiquitination of the tagged to BET inhibitors Bromodomain proteins, BRD2 and BRD. The encapsulation and controlled release of BET-PROTACs through their vectorization with antibodies, like trastuzumab, could facilitate their pharmacokinetic and efficacy profile. Antibody conjugated nanoparticles (ACNPs) using PROTACs have not been designed ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Felipe de la Cruz‐Martínez, Marc Martínez de Sarasa Buchaca, Javier Martı́nez, Juan Tejeda, Juan Fernández‐Baeza, Carlos Alonso‐Moreno, Ana M. Rodrı́guez, José A. Castro‐Osma, Agustín Lara‐Sánchez,
Novel bimetallic zinc acetate complexes supported by heteroscorpionate ligands have been developed for the ring-opening copolymerization of cyclohexene oxide and CO2 and the terpolymerization of cyclohexene oxide, phthalic anhydride, and CO2. Heteroscorpionate ligands precursors L1–L3 were reacted with two equivalents of zinc acetate to afford the dinuclear zinc complexes [{Zn(κ3-bpzappe)}(μ-O2CCH3)3-{Zn(HO2CCH3)}] (1), [{Zn(κ3-bpzbdmape)}(μ-O2CCH3)3-{Zn(HO2CCH3)}] (2), and [{Zn(κ3-bpzbdeape)}(μ-O2CCH3) ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2020 - American Chemical Society | Inorganic Chemistry
Enrique Niza, Cristina Nieto‐Jiménez, María del Mar Noblejas‐López, Iván Bravo, José A. Castro‐Osma, Felipe de la Cruz‐Martínez, Marc Martínez de Sarasa Buchaca, Inmaculada Posadas, Jesús Canales‐Vázquez, Agustín Lara‐Sánchez, Daniel Hermida‐Merino, Eduardo Solano, Alberto Ocaña, Carlos Alonso‐Moreno,
The effect on the activity in breast cancer models of the small tyrosine kinase inhibitor dasatinib (DAS), either alone or in combination with other antitumoral agents, has been recently explored. However, DAS is characterized by its low and highly pH-dependent solubility, which could lead to poor uptake of the drug limiting its tumoral efficacy. Thus far, the development of safe and efficient delivery vehicles of DAS to improve the therapeutic efficacy minimizing the toxicity profile is still required. ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2019 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Enrique Niza, José A. Castro‐Osma, Inmaculada Posadas, Carlos Alonso‐Moreno, Iván Bravo, Andrés Garzón-Ruíz, Jesús Canales‐Vázquez, Valentı́n Ceña, Agustín Lara‐Sánchez, José Albaladejo, Antonío Otero,
Bare polycaprolactones with controlled molar mass and dispersity were employed to manufacture biodegradable devices, which were applied for doxorubicin delivery in glioblastoma. Micro- and nanoscale devices were prepared by emulsion formation or by a combination of precipitation and hydrolysis. The carriers were characterized by scanning electron microscopy, dynamic light scattering techniques, thermogravimetric analysis and differential scanning calorimetry. The encapsulation parameters and drug- ...
Tópico(s): Graphene and Nanomaterials Applications
2019 - Elsevier BV | International Journal of Pharmaceutics
Sonia Sobrino, Marta Navarro, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Andrés Garcés, Agustín Lara‐Sánchez, José A. Castro‐Osma,
Chiral bifunctional and bicomponent NNO-scorpionate zinc-based catalysts have been developed for the fixation of CO 2 into cyclic carbonates with broad substrate scope and functional group tolerance under mild and solvent-free conditions.
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2019 - Royal Society of Chemistry | Dalton Transactions
Enrique Niza, María del Mar Noblejas‐López, Iván Bravo, Cristina Nieto‐Jiménez, José A. Castro‐Osma, Jesús Canales‐Vázquez, Agustín Lara‐Sánchez, Eva María Galán‐Moya, Miguel Burgos, Alberto Ocaña, Carlos Alonso‐Moreno,
Dasatinib (DAS) is a multikinase inhibitor that acts on several signaling kinases. DAS is used as a second-line treatment for chronic accelerated myeloid and Philadelphia chromosome-positive acute lymphoblastic leukemia. The therapeutic potential of DAS in other solid tumours is under evaluation. As for many other compounds, an improvement in their pharmacokinetic and delivery properties would potential augment the efficacy. Antibody-targeted biodegradable nanoparticles can be useful in targeted ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2019 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Miguel A. Gaona, Felipe de la Cruz‐Martínez, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Carlos Alonso‐Moreno, Ana M. Rodrı́guez, Antonio Rodríguez‐Diéguez, José A. Castro‐Osma, Antonío Otero, Agustín Lara‐Sánchez,
Helical aluminium complexes have been prepared and used as catalysts for cyclic carbonate synthesis.
Tópico(s): Catalysis for Biomass Conversion
2019 - Royal Society of Chemistry | Dalton Transactions
Javier Martı́nez, Felipe de la Cruz‐Martínez, Miguel A. Gaona, Esther Pinilla-Peñalver, Juan Fernández‐Baeza, Ana M. Rodrı́guez, José A. Castro‐Osma, Antonío Otero, Agustín Lara‐Sánchez,
New bifunctional aluminum complexes have been prepared with the aim of studying the effect of a counterion on the synthesis of cyclic carbonates from epoxides and carbon dioxide (CO2). Neutral ligand 1 was used as a precursor to obtain four novel mesylate, chloride, bromide, and iodide zwitterionic NNO ligands (2–5). The reaction of these ligands with 1 or 2 equiv of AlR3 (R = Me, Et) allowed the synthesis of mono- and bimetallic bifunctional aluminum complexes [AlR2(κ2-mbpzappe)]X [X = Cl, R = Me (6), Et (7); ...
Tópico(s): Chemical Synthesis and Reactions
2019 - American Chemical Society | Inorganic Chemistry
Felipe de la Cruz‐Martínez, Marc Martínez de Sarasa Buchaca, Javier Martı́nez, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Antonio Rodríguez‐Diéguez, José A. Castro‐Osma, Agustín Lara‐Sánchez,
The coupling reaction of carbon dioxide and terminal, internal, and highly substituted epoxides derived from renewable resources such as furfural, limonene, carvone, carvyl acetate, terpinen-4-ol, or ionone leads to the synthesis of new bioderived cyclic carbonates using an efficient aluminum catalyst under mild and solvent-free reaction conditions. Interestingly, the synthesis of highly substituted bioderived cyclic carbonates can occur with excellent diastereoselectivity, obtaining in some cases ...
Tópico(s): biodegradable polymer synthesis and properties
2019 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Javier Martı́nez, Marc Martínez de Sarasa Buchaca, Felipe de la Cruz‐Martínez, Carlos Alonso‐Moreno, Luis F. Sánchez‐Barba, Juan Fernández‐Baeza, Ana María Rodríguez, Antonio Rodríguez‐Diéguez, José A. Castro‐Osma, Antonío Otero, Agustín Lara‐Sánchez,
Aluminium complexes have been developed as versatile catalysts for the preparation of polyesters.
Tópico(s): Carbon dioxide utilization in catalysis
2018 - Royal Society of Chemistry | Dalton Transactions
Danay Osorio Meléndez, Agustín Lara‐Sánchez, Javier Martı́nez, Xiao Wu, Antonío Otero, José A. Castro‐Osma, Michael North, René S. Rojas,
Abstract A series of inexpensive and sustainable amidinate aluminium complexes has been developed as catalysts for the chemical fixation of carbon dioxide into cyclic carbonates. The reactions using terminal epoxides as substrates were carried out at room temperature and one bar of carbon dioxide pressure in the presence of tetrabutylammonium iodide as cocatalyst in the absence of solvent. Under these reaction conditions, excellent conversions and selectivities were achieved for a broad range of ...
Tópico(s): biodegradable polymer synthesis and properties
2018 - Wiley | ChemCatChem
José A. Castro‐Osma, Javier Martı́nez, Felipe de la Cruz‐Martínez, María P. Caballero, Juan Fernández‐Baeza, Julián Rodríguez‐López, Antonío Otero, Agustín Lara‐Sánchez, Juan Tejeda,
Metal-free catalysts for cyclic carbonates synthesis.
Tópico(s): Asymmetric Hydrogenation and Catalysis
2018 - Royal Society of Chemistry | Catalysis Science & Technology
Marc Martínez de Sarasa Buchaca, Felipe de la Cruz‐Martínez, Javier Martı́nez, Carlos Alonso‐Moreno, Juan Fernández‐Baeza, Juan Tejeda, Enrique Niza, José A. Castro‐Osma, Antonío Otero, Agustín Lara‐Sánchez,
The optimization of an organoaluminum catalytic system for the copolymerization of epoxides and anhydrides is presented. For this purpose, the influence of different variables in the process, such as catalysts, cocatalyst, solvent, or substrates, has been analyzed. Kinetic studies, a proposal for the catalytic mechanism, and full characterization of the copolymers obtained are also discussed. Finally, a new copolymer, poly(limonene succinate), obtained by the optimized catalytic system is reported.
Tópico(s): Chemical Synthesis and Reactions
2018 - American Chemical Society | ACS Omega
Andrés Garcés, Luis F. Sánchez‐Barba, Juan Fernández‐Baeza, Antonío Otero, Israel Fernández, Agustín Lara‐Sánchez, Ana M. Rodrı́guez,
The reaction of the highly sterically demanding NNN′-heteroscorpionate protioligands pbptamd-H, tbptamd-H, and phbptamd-H (a) and the low sterically hindered analogs pbpamd-H, tbpamd-H, and phbpamd-H (b), with 1 equiv of AlR3 (R = Me, Et) proceed in high yields to give two families of complexes: the mononuclear dialkyl aluminum bidentate-acetamidinates [AlR2(κ2-N′N′)] (κ2-N′N′ = pbptamd, R = Me 1, Et 2; tbptamd, R = Me 3, Et 4; phbptamd, R = Me 5, Et 6) and the monodentate-acetamidinates [AlR2(κ2-NN′)] (κ2-NN′ = tbpamd, ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2018 - American Chemical Society | Inorganic Chemistry
Felipe de la Cruz‐Martínez, Javier Martı́nez, Miguel A. Gaona, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Ana M. Rodrı́guez, José A. Castro‐Osma, Antonío Otero, Agustín Lara‐Sánchez,
Bifunctional aluminum complexes supported by novel zwitterionic NNO-donor scorpionate ligands were found to be efficient bifunctional catalysts for cyclic carbonate synthesis from terminal and internal epoxides in good yields and with broad substrate scope. Neutral scorpionate ligands (1–2) were designed and used as precursors to obtain two novel zwitterionic NNO-heteroscorpionate ligands (3–4). Reaction of 3 or 4 with [AlX3] (X = Me, Et) in a 1:1 or 1:2 molar ratio afforded the mononuclear and dinuclear ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2018 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Javier Martı́nez, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, José A. Castro‐Osma, Agustín Lara‐Sánchez, Antonío Otero,
Abstract A new lanthanum heteroscorpionate complex has shown exceptional catalytic activity for the synthesis of cyclic carbonates from epoxides and carbon dioxide. This catalyst system also promotes the reaction of bio‐based epoxides to give an important class of bis(cyclic carbonates) that can be further used for the production of bio‐derived non‐isocyanate polyurethanes. The catalytic process requires low catalyst loading and mild reaction conditions for the synthesis of a wide range of cyclic ...
Tópico(s): Catalysis for Biomass Conversion
2017 - Wiley | ChemSusChem
Danay Osorio Meléndez, José A. Castro‐Osma, Agustín Lara‐Sánchez, René S. Rojas, Antonío Otero,
ABSTRACT A series of new alkyl mono‐ and bimetallic aluminum complexes supported by novel amidinate ligands has been prepared in very high yields. These complexes were fully characterized by spectroscopic methods. Alkyl aluminum complexes 1 – 6 were investigated as catalysts for the ring‐opening polymerization and copolymerization of ε‐caprolactone and L ‐lactide. Under the optimal reaction conditions, complex 5 acts as an efficient single‐component initiator for the ring‐opening polymerization and ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2017 - Wiley | Journal of Polymer Science Part A Polymer Chemistry
Antonío Otero, Juan Fernández‐Baeza, Luis F. Sánchez‐Barba, Sonia Sobrino, Andrés Garcés, Agustín Lara‐Sánchez, Ana M. Rodrı́guez,
Activity enhancement in the ROP of rac -LA through the cooperative effect of two remote zinc metals in N,N,O-scorpionate binuclear trisalkyls.
Tópico(s): Peptidase Inhibition and Analysis
2017 - Royal Society of Chemistry | Dalton Transactions
Andrés Garcés, Luis F. Sánchez‐Barba, Juan Fernández‐Baeza, Antonío Otero, Agustín Lara‐Sánchez, Ana M. Rodrı́guez,
The reaction of the low sterically hindered heteroscorpionate lithium acetamidinates [Li(κ3-NNN)(thf)] {NNN = pbpamd (1) [pbpamd = N,N′-diisopropylbis(3,5-dimethylpyrazol-1-yl)acetamidinate], tbpamd (2) [tbpamd = N-ethyl-N′-tert-butylbis(3,5-dimethylpyrazol-1-yl)acetamidinate], ttbpamd (3) [ttbpamd = N,N′-di-tert-butylbis(3,5-dimethylpyrazol-1-yl)acetamidinate], phbpamd (4) [phbpamd = N,N′-di-p-tolylbis(3,5-dimethylpyrazol-1-yl)acetamidinate] and the highly sterically demanding [Li(κ3-phbptamd)(thf)] (5) [phbptamd = N,N′- ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2017 - American Chemical Society | Organometallics