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... human use? Richard Johnson reports. Photographs by Ed Kashi Picture Gallery Great North Eastern Railway The Sunday ...
1998 - Gale Group | Sunday Times HA GDA
Davoud Sadeghzadeh-Ahari, Mohammadreza Hassandokht, Abdolkarim Kashi, Ahmed Amri, Khoshnood Alizadeh,
This study was carried out to assess the genetic diversity and heritability of various agronomic traits using twenty fenugreek landraces from Iran. The trial was conducted at Maragheh experiment station in North-west of Iran under rainfed (RF) and irrigated (IR) conditions during 2008 cropping season. Results of combined analysis of variance showed significant differences among landraces for all traits except for harvest index under rainfed conditions and in number of pods per plant, number of seeds ...
Tópico(s): Agronomic Practices and Intercropping Systems
2010 - Academic Journals | African Journal of Plant Science
Aazar S. Kashi, Ahmed I. Abd El-Rahman, John C. Cartledge, Sadegh Etemad,
An estimation method for the nonlinear signal-to-noise ratio (SNR) is extended to simultaneously identify the shaping distribution for rate-adaptive probabilistically shaped (PS) 64-ary quadrature amplitude modulation (QAM) constellations. An artificial neural network (ANN) is trained with the fiber nonlinearity induced amplitude noise covariance and phase noise correlation extracted from received symbols. The identification employs estimates of the nonlinear signal-to-noise ratio (SNR nl ) and nonlinear ...
Tópico(s): Error Correcting Code Techniques
2019 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology
Niaz Ahmad, Habib Kashi, Ahmed Hazem Helmy, J. Hadingham, David Potts, J.P.A. Lodge,
Tópico(s): Dialysis and Renal Disease Management
1997 - Elsevier BV | Transplantation Proceedings
Sabah Allarakia, Hassan A. Khayat, Moyassar M. Karami, Abdulaziz Aldakhil, Ahmed M. Kashi, Abdulrahman H. Algain, Mohammad Akram Khan, Loai S. Alghifees, Raed E. Alsulami,
To describe the clinical features of mirror syndrome and to correlate the effects of different treatments with the fetal outcomes.Online search up to May 2016 was conducted in the PubMed, Embase (Ovid platform) and clinicalTrials.gov without restrictions of language, date or journal. Only papers providing both fetal and maternal presentations and outcomes were included.The study included 74 papers (n=111), with an additional two patients diagnosed at our center (n=113). The mean gestational age at ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2017 - De Gruyter | Journal of Perinatal Medicine
Avinash Singh, Asar Ahmed, Kashi Nath Prasad, Sonali Khanduja, Satyendra Kumar Singh, Janmejai Kumar Srivastava, N. S. Gajbhiye,
The antimicrobial effects of copper ions and salts are well known, but the effects of cuprous oxide nanoparticles (Cu2O-NPs) on staphylococcal biofilms have not yet been clearly revealed. The present study evaluated Cu2O-NPs for their antibacterial and antibiofilm activities against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA). Nanoscaled Cu2O, generated by solution phase technology, contained Cu2O octahedral nanoparticles. Field emission ...
Tópico(s): Advanced Nanomaterials in Catalysis
2015 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Ähmed Kamal, M. Kashi Reddy, M. Janaki Ramaiah, Rajender, Jhansi Reddy, Y. V. V. Srikanth, D. Dastagiri, E. Vijaya Bharathi, S. N. C. V. L. Pushpavalli, P.N. Sarma, Manika Pal‐Bhadra,
A series of new estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (E2-PBD) conjugates (3a–f, 4a–f and 5a–f) with different linker architectures including a triazole moiety have been designed and synthesized. All the 18 compounds have been evaluated for their anticancer activity and it is observed that some of the compounds particularly 4c–e and 5c,d exhibited significant anticancer activity. The detailed biological aspects relating to the cell cycle effects and tubulin depolymerization activity have ...
Tópico(s): Cancer Treatment and Pharmacology
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry
Ähmed Kamal, M. Kashi Reddy, M. Janaki Ramaiah, Y. V. V. Srikanth, Rajender, Vangala Santosh Reddy, G. Bharath Kumar, S. N. C. V. L. Pushpavalli, Indira Bag, Aarti Juvekar, Subrata Sen, Surekha M. Zingde, Manika Pal‐Bhadra,
Abstract A library of new aryl‐substituted naphthalene C8‐linked pyrrolo[2,1‐ c ][1,4]benzodiazepine (PBD) conjugates with various linker architectures were designed, synthesized, and evaluated for their anticancer activity against a panel of 11 human cancer cell lines. All 32 conjugates show anticancer potential, with some of them exhibiting particularly high activity (0.01–0.19 μ M ). Thermal denaturation studies showed effective DNA binding capacity relative to DC‐81. In assays for biological activity ...
Tópico(s): Cancer Treatment and Pharmacology
2011 - Wiley | ChemMedChem
Ähmed Kamal, M. Kashi Reddy, Thokhir Basha Shaik, Rajender, Y. V. V. Srikanth, Vangala Santhosh Reddy, G. Bharath Kumar, Shasi V. Kalivendi,
Tópico(s): Microbial Natural Products and Biosynthesis
2012 - Elsevier BV | European Journal of Medicinal Chemistry
Ähmed Kamal, M. Kashi Reddy, Viswanath Arutla,
Introduction: Imidazothiazole derivatives have long been therapeutically used for the treatment of various diseases. In recent years, the imidazothiazole and chalcone moieties have emerged as important pharmacophores in the development of antitumor agents. Imidazothiazole–chalcone conjugates can be accessed by covalently binding these two powerful pharamacophore units. These conjugates are known to exhibit a wide range of biological properties, including anticancer, antimicrobial, anti-inflammatory ...
Tópico(s): Synthesis and Biological Evaluation
2013 - Taylor & Francis | Expert Opinion on Drug Discovery
Ali H. Jawad, Ahmed Saud Abdulhameed, Elmira Kashi, Zaher Mundher Yaseen, Zeid A. ALOthman, Mohammad Rizwan Khan,
Kaolin clay (KN) was employed as an inorganic filler to modify a cross-linked chitosan-glyoxal as Schiff’s-based chitosan composite derivative (CTS-GLY). The resulting (CTS-GLY/KN) was found to be a promising composite synthetic biopolymer that can be potentially utilized for color removal as well as COD reduction of an industrial anionic dye (remazol brilliant blue R, RBBR). The surface porosity, crystallinity, morphology, functionality, charge, and amine content of the CTS-GLY/KN were studied using ...
Tópico(s): Recycling and utilization of industrial and municipal waste in materials production
2021 - Springer Science+Business Media | Journal of Polymers and the Environment
Ahmed Kamal, Y. V. V. Srikanth, Naseer Ahmed Khan Mohammed, Farheen Sultana, Kashi Reddy Methuku,
Benzothiazole scaffold comprises a bicyclic ring system and is known to exhibit a wide range of biological properties including antimicrobial and anticancer activities. Benzothiazole derivatives have long been therapeutically used for the treatment of various diseases. However, in recent years, 2-arylbenzothiazoles have emerged as an important pharmacophore in the development of antitumor agents. The promising biological profile and synthetic accessibility have been attractive in the design and ...
Tópico(s): Computational Drug Discovery Methods
2012 - Taylor & Francis | Expert Opinion on Investigational Drugs
M.T.H. Siddiqui, Humair Ahmed Baloch, Sabzoi Nizamuddin, Sima Kashi, Faisal Amri Tanjung, Nazia Hossain, Shaukat Ali Mazari, Nabisab Mujawar Mubarak, Gregory Griffin, Madapusi Srinivasan,
Novel magnetic bio-nanocomposites were fabricated using polypropylene (PP) as polymer matrix and graphene supported magnetic carbon nanocomposite (MCNC, produced by solvothermal carbonization co-precipitation route integrating low-cost graphene, renewable biomass and iron oxide nanoparticles) serving as filler by incorporating nano-fillers of loading 5%, 10% and 15% with PP using a convenient and time efficient route melt processing. Utilizing waste biomass as integral part of MCNC offers cost effective ...
Tópico(s): Polymer Nanocomposites and Properties
2021 - Elsevier BV | Journal of environmental chemical engineering
Ahmed Saud Abdulhameed, Ali H. Jawad, Elmira Kashi, Khairul Adzfa Radzun, Zeid A. ALOthman, Lee D. Wilson,
Herein, an environmentally friendly and efficient adsorbent of microalgae (MAG) was applied for the removal of crystal violet (CV) and methylene blue (MB) dyes from aqueous solutions. Multivariate modeling and optimization of CV and MB dyes removal onto MAG via Box-Behnken design (BBD) were investigated depending on three variables i.e. MAG dosage (20–100 mg), initial pH (4–10), and adsorption time (2–6 min). The adsorption kinetics and isotherm analyses revealed that the pseudo-second-order and Langmuir ...
Tópico(s): Water Quality Monitoring and Analysis
2022 - Elsevier BV | Algal Research
Ähmed Kamal, Rajender, D. Rajasekhar Reddy, M. Kashi Reddy, G. Balakishan, Thokhir Basha Shaik, Mukesh Chourasia, G. Narahari Sastry,
C2-Fluoro substituted DC-81, and its dimers that comprise of two C2-fluoro substituted DC-81 subunits tethered to their C8-position through simple alkane spacers as well as piperazine moiety side-armed with symmetrical alkyloxy spacers have been designed and synthesized. These fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines have shown remarkable DNA-binding ability and most of them possess promising anticancer activity, having GI50 values in micromolar to nanomolar concentration range. DNA ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry
Ahmed Saud Abdulhameed, Ahmad Hapiz, Salis A. Musa, Elmira Kashi, Ruihong Wu, Zeid A. ALOthman, Ali H. Jawad, Sameer Algburi,
In this study, a new biocomposite magnetic adsorbent (magnetic glyoxal-chitosan Schiff base/organically modified montmorillonite (MCTS-GOX/OMMT)) was synthesized and employed for the adsorption of reactive blue 19 dye (RB19) from aqueous environment. The physicochemical properties of the MCTS-GOX/OMMT were confirmed by using various characterization techniques such as BET, XRD, FTIR, SEM-EDX, VSM, and pHpzc. The adsorption key variables were statistically optimized via Box-Behnken design (BBD) And accordingly ...
Tópico(s): Graphene and Nanomaterials Applications
2023 - Elsevier BV | International Journal of Biological Macromolecules
Hamza Ahmed-Laloui, Hadjer Zaak, Abderrahman Rahmani, Kashi Imad, Smaïn Chemat, Mohamed Djamel Mıara, Nora Cherb, Mouna Derdour,
Artemisinin, a natural product, has received considerable attention in the last few years as a potent antimalarial drug.This study reports the presence of Artemisinin in three Algerian wild Artemisia species assessed by HPLC method: A. herba-alba (AH), A. campestris subsp. glutinosa (AC), and A. judaica subsp sahariensis (AJ).The HPLC analysis of the hexane extracts, showed a difference in artemisinin content in studied species with a yield of 0.64%, 0.34% and 0.04% for AC, AH and AJ, respectively. ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2022 - Taylor & Francis | Natural Product Research
Tong-Young Lee, Robert M. Tjin Tham Sjin, Shahla Movahedi, Bissan Ahmed, Elke Pravda, Kin-Ming Lo, Stephen D. Gillies, Judah Folkman, Kashi Javaherian,
Abstract Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino acids gives rise to a molecule that is devoid of zinc, resulting in no antitumor activity. Our goal was to develop a new version of endostatin that does not show such deficiency. Experimental Design: A recombinant human endostatin conjugated to the Fc ...
Tópico(s): Cell Adhesion Molecules Research
2008 - American Association for Cancer Research | Clinical Cancer Research
Ähmed Kamal, Y. V. V. Srikanth, M. Naseer A. Khan, Md. Ashraf, M. Kashi Reddy, Farheen Sultana, Tandeep Kaur, Gousia Chashoo, Nitasha Suri, Irum Sehar, Zahoor A. Wani, Arpita Saxena, Parduman Raj Sharma, Shashi Bhushan, Dilip M. Mondhe, Ajit Kumar Saxena,
Tópico(s): Quinazolinone synthesis and applications
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry
Ähmed Kamal, E. Vijaya Bharathi, Jhansi Reddy, M. Janaki Ramaiah, D. Dastagiri, M. Kashi Reddy, Viswanath Arutla, Lakshminarayan Reddy Teegala, Thokhir Basha Shaik, S. N. C. V. L. Pushpavalli, Manika Pal Bhadra,
A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2010 - Elsevier BV | European Journal of Medicinal Chemistry
Ähmed Kamal, D. Dastagiri, M. Janaki Ramaiah, Jhansi Reddy, E. Vijaya Bharathi, M. Kashi Reddy, Milind Sagar, Lakshminarayan Reddy Teegala, S. N. C. V. L. Pushpavalli, Manika Pal‐Bhadra,
A series of anilino substituted pyrimidine sulfonamides were prepared and evaluated for their anticancer activity. These sulfonamides showed promising activity with IC50 values ranging from 5.6 to 12.3 μM. The detailed biological aspects of some of the promising compounds (3d, 3e and 3g) on the K562 cell line were studied. Interestingly, compounds induced G1 cell cycle arrest and down regulation of G1 phase cell cycle regulatory proteins such as cyclin D1, CDK4. These compounds also exhibited inhibition ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2011 - Elsevier BV | European Journal of Medicinal Chemistry
Ähmed Kamal, Y. V. V. Srikanth, M. Janaki Ramaiah, M. Naseer A. Khan, M. Kashi Reddy, Md. Ashraf, Lavanya Anumula, S. N. C. V. L. Pushpavalli, Manika Pal‐Bhadra,
A series of bisindole–pyrrolobenzodiazepine conjugates (5a–f) linked through different alkane spacers was prepared and evaluated for their anticancer activity. All compounds exhibited significant anticancer potency and the most potent compounds 5b and 5e were taken up for detailed studies on MCF-7 cell line. Cell cycle effects were examined apart from investigating the inhibition of tubulin polymerization for compounds 2a, 2b, 5b and 5e at 2 μM. FACS analysis showed that at higher concentrations ( ...
Tópico(s): Cancer therapeutics and mechanisms
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Ähmed Kamal, G. Bharath Kumar, Sowjanya Polepalli, Anver Basha Shaik, Vangala Santhosh Reddy, M. Kashi Reddy, Ch. Ratna Reddy, Rasala Mahesh, Jeevak Sopanrao Kapure, Nishant Jain,
Abstract A series of aminostilbene—arylpropenones were designed and synthesized by Michael addition and were investigated for their cytotoxic activity against various human cancer cell lines. Some of the investigated compounds exhibited significant antiproliferative activity against a panel of 60 human cancer cell lines of the US National Cancer Institute, with 50 % growth inhibition (GI 50 ) values in the range from <0.01 to 19.9 μ M . One of the compounds showed a broad spectrum of antiproliferative efficacy ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2014 - Wiley | ChemMedChem
Ähmed Kamal, Jhansi Reddy, M. Janaki Ramaiah, E. Vijaya Bharathi, D. Dastagiri, M. Kashi Reddy, S. N. C. V. L. Pushpavalli, Manika Pal‐Bhadra,
A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.
Tópico(s): Synthesis and Reactivity of Heterocycles
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Ähmed Kamal, Y. V. V. Srikanth, Thokhir Basha Shaik, M. Naseer A. Khan, Md. Ashraf, M. Kashi Reddy, K. Anil Kumar, Shasi V. Kalivendi,
A series of 2-anilinonicotinyl linked 1,3,4-oxadiazoles was synthesized and evaluated for their antitumour activity against various cancer cell lines, inhibition of tubulin polymerization and cell cycle effects. Some of these compounds showed good antiproliferative activity with GI50 values ranging from 4.57 to 97.09 μM in the human cancer cell lines and one of the compounds 5m showed potent antitumour efficacy in all the cell lines tested. This compound also inhibited tubulin polymerization under ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2011 - Royal Society of Chemistry | MedChemComm
Ähmed Kamal, G. Bharath Kumar, Veena Nayak, Vangala Santhosh Reddy, Anver Basha Shaik, Rajender Rajender, M. Kashi Reddy,
A series of imidazopyridine/imidazopyrimidine-benzimidazole conjugates ( 11a–t ) were synthesized and evaluated for their antiproliferative activity.
Tópico(s): Cancer Mechanisms and Therapy
2014 - Royal Society of Chemistry | MedChemComm
Ähmed Kamal, M. Kashi Reddy, Thokhir Basha Shaik, Rajender Rajender, Y. V. V. Srikanth, Vangala Santhosh Reddy, G. Bharath Kumar, Shasi V. Kalivendi,
Abstract A library of a new class of benzimidazoles (VII) (30 examples) is designed, synthesized and evaluated for their anticancer activity.
Tópico(s): Click Chemistry and Applications
2012 - Wiley | ChemInform
Ähmed Kamal, Vangala Santhosh Reddy, Santosh Karnewar, Sumit S. Chourasiya, Anver Basha Shaik, G. Bharath Kumar, Chandan Kishor, M. Kashi Reddy, M. Rao, Ananthamurthy Nagabhushana, Kallaganti V. S. Ramakrishna, A. Addlagatta, Srigiridhar Kotamraju,
Abstract A library of imidazopyridine–oxindole conjugates was synthesised and investigated for anticancer activity against various human cancer cell lines. Some of the tested compounds, such as 10 a , 10 e , 10 f , and 10 k , exhibited promising antiproliferative activity with GI 50 values ranging from 0.17 to 9.31 μ M . Flow cytometric analysis showed that MCF‐7 cells treated by these compounds arrested in the G 2 /M phase of the cell cycle in a concentration‐dependent manner. More particularly, compound ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2013 - Wiley | ChemMedChem
Ähmed Kamal, Rajender, M. Kashi Reddy, Vangala Santhosh Reddy, G. Bharath Kumar,
A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.
Tópico(s): Cancer therapeutics and mechanisms
2013 - Bentham Science Publishers | Medicinal Chemistry
Ähmed Kamal, Vangala Santhosh Reddy, M.V.P.S. Vishnuvardhan, G. Bharath Kumar, Anver Basha Shaik, Sumit S. Chourasiya, M. Kashi Reddy, Ibrahim Bin Sayeed, Praveen Reddy Adiyala, Nishant Jain,
2-Anilinopyridine–arylpropenone conjugates as novel tubulin inhibitors and apoptotic inducers.
Tópico(s): Bioactive Compounds and Antitumor Agents
2015 - Royal Society of Chemistry | RSC Advances