... Noriko Mizuta. Tokyo : Gakuyō Shobō, 1991. 81–95. Maeda, Ai. Kindai Dokusha no Seiritsu. Maeda Ai Chossaku Shu vol. 2. Tokyo : Chikuma Shobō, 1989. ...
Tópico(s): Asian Culture and Media Studies
2003 - Wiley | The Journal of Popular Culture
... is presently working on a translated anthology of Maeda Ai's essays and a manuscript examining Japanese urban ...
Tópico(s): Hong Kong and Taiwan Politics
1999 - Duke University Press | differences
... 1: Meiji kaikaki bungakushū, ed. Okitsu Kaname and Maeda Ai (Tōkyō: Kadokawa, 1970), p. 57. Translation quoted from: " ...
Tópico(s): Chinese history and philosophy
2008 - Taylor & Francis | Food and Foodways
Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata,
// Riki Okita 1 , Ai Maeda 1 , Katsuhiko Shimizu 1 , Yuji Nojima 1 , Shinsuke Saisho 1 and Masao Nakata 1 1 Department of General Thoracic ...
Tópico(s): Lung Cancer Research Studies
2019 - Impact Journals LLC | Oncotarget
Yukie Iwabu-Itoh, Bazartseren Boldbaatar, Oyunnomin Naranbaatar, Enkhmandakh Yondonjamts, Kiwa Furuno, Kyunglee Lee, Kozue Sato, Hiroki Kawabata, Nobuhiro Takada, Masako Andoh, Hiroko Kajita, Yosaburo Oikawa, Minoru Nakao, Makoto Ohnishi, Masahisa Watarai, Hiroshi Shimoda, Ken Maeda, Ai Takano,
Borrelia miyamotoi, recently recognized as a human pathogenic spirochete, was isolated from Ixodes persulcatus and I. ovatus in northern Mongolia and Honshu Island, a major island in Japan. Although no human B. miyamotoi infections have been reported in Mongolia, the prevalence of B. miyamotoi in ticks from Mongolia is higher than that in ticks from Hokkaido, Japan, where human cases have been reported. Moreover, the multi-locus sequence analysis of cultured isolates revealed that B. miyamotoi isolates ...
Tópico(s): Viral Infections and Vectors
2017 - Elsevier BV | Ticks and Tick-borne Diseases
Kiwa Furuno, Kyunglee Lee, Yukie Itoh, Kazuo Suzuki, Kenzo Yonemitsu, Ryusei Kuwata, Hiroshi Shimoda, Masahisa Watarai, Ken Maeda, Ai Takano,
The genus Borrelia comprises arthropod-borne bacteria, which are infectious agents in vertebrates. They are mainly transmitted by ixodid or argasid ticks. In Hokkaido, Japan, Borrelia spp. were found in deer and Haemaphysalis ticks between 2011 and 2013; however, the study was limited to a particular area. Therefore, in the present study, we conducted large-scale surveillance of ticks and wild animals in the western part of the main island of Japan. We collected 6,407 host-seeking ticks from two ...
Tópico(s): Vector-Borne Animal Diseases
2017 - Public Library of Science | PLoS ONE
Shoji Nagao, Maiko Miwa, Naoko Maeda, Ai Kogiku, Kasumi Yamamoto, Akemi Morimoto, Senn Wakahashi, Kotaro Ichida, Tamotsu Sudo, Satoshi Yamaguchi, Toshiko Sakuma, Kiyoshi Fujiwara,
Objective Neuroendocrine carcinoma of the cervix is a rare and aggressive subtype of cervical cancer and includes small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC). We conducted a single-institution retrospective review to explore the pattern of treatments and outcomes with the aim of defining an optimum treatment strategy for these carcinomas. Methods Twenty-three consecutive patients with SCNEC or LCNEC of the cervix diagnosed at the Hyogo Cancer Center between 1996 ...
Tópico(s): Gestational Trophoblastic Disease Studies
2015 - BMJ | International Journal of Gynecological Cancer
Takeshi Watanabe, Shuhei Shibano, Hideto Maeda, Ai Sugitani, Michinobu Katayama, Yoshinori Matsumoto, Yasuaki Einaga,
A prototype microfluidic device using boron-doped diamond (BDD) electrodes patterned on an alumina chip was designed and fabricated. Electrochemical microfluidic devices have advantages in that the amount of sample required is small, the measurement throughput is high, different functions can be integrated on a single device, and they are highly durable. In using the device for the flow injection analysis of oxalic acid, the application of a brief conditioning step ensured that the reproducibility ...
Tópico(s): Electrochemical Analysis and Applications
2015 - Elsevier BV | Electrochimica Acta
Yu Ishima, Di Chen, Jun Fang, Hiroshi Maeda, Ai Minomo, Ulrich Kragh‐Hansen, Toshiya Kai, Toru Maruyama, Masaki Otagiri,
Macromolecules have been developed as carriers of low-molecular-weight drugs in drug delivery systems (DDS) to improve their pharmacokinetic profile or to promote their uptake in tumor tissue via enhanced permeability and retention (EPR) effects. In the present study, recombinant human serum albumin dimer (AL-Dimer), which was designed by linking two human serum albumin (HSA) molecules with the amino acid linker (GGGGS)2, significantly accumulated in tumor tissue even more than HSA Monomer (AL-Monomer) ...
Tópico(s): Metal complexes synthesis and properties
2012 - American Chemical Society | Bioconjugate Chemistry
Masumi Kurasawa, Tetsuo Maeda, Ai Oba, Takuya Yamamoto, Hiroyuki Sasaki,
Tópico(s): Wound Healing and Treatments
2011 - Elsevier BV | Biochemical and Biophysical Research Communications
Sanae Maeda, Ai Kawamoto, Yumi Yatani, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko,
The glial glutamate transporter GLT-1 is abundantly expressed in astrocytes and is crucial for glutamate removal from the synaptic cleft. Decreases in glutamate uptake activity and expression of spinal glutamate transporters are reported in animal models of pathological pain. However, the lack of available specific inhibitors and/or activators for GLT-1 makes it difficult to determine the roles of spinal GLT-1 in inflammatory and neuropathic pain. In this study, we examined the effect of gene transfer ...
Tópico(s): Ion channel regulation and function
2008 - SAGE Publishing | Molecular Pain
Hirokazu Hara, Hidemasa Kobayashi, Mayumi Maeda, Ai Ueno, Yohko Kobayashi,
Soluble aluminum in rainwater was separated into three categories: free aluminum (Al3+), fluoride complexes (sum of AlF2+ and AlF2+), and other forms of aluminum. The free form of the aluminum ion (Al3+) was directly obtained from the separation data of aluminum species according to their charge using gradient elution cation-exchange chromatography. The aluminum fluoride complexes were estimated by combining the data of the free and total fluoride determined using a fluoride ion-selective electrode, ...
Tópico(s): Chemical Analysis and Environmental Impact
2001 - American Chemical Society | Analytical Chemistry
Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi,
Tauopathy is characterized by the fibrillar tau accumulation in neurons and glial cells. In order to advance our understanding of the causative mechanisms of tauopathy, neuroinflammation, which has been suggested to play important roles in disease progression, will require particular attention. Neuroinflammation is characterized predominantly by microglial activation. At present, it is still under debate whether microglial activation is a cause or a result of neurodegeneration. To search for a temporal ...
Tópico(s): Adenosine and Purinergic Signaling
2018 - IOS Press | Journal of Alzheimer s Disease
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata,
There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro.Resected lung cancer specimens were analyzed for PD-L1 and COX2 expression by immunohistochemical analysis. Next, co-localization of PD-L1 and COX2 expression was analyzed by double-fluorescence staining. Lastly, the effect of COX2 inhibition on the expression ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2018 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata,
Programmed cell death-1 ligand 1 (PD-L1), tumor-infiltrating CD8-positive T lymphocytes (CD8-positive TILs), and cyclooxygenase-2 (Cox-2) have been used as prognostic tools in patients with lung adenocarcinoma. We conducted a retrospective review of data from 170 patients who had undergone pulmonary resection as an initial treatment for clinical T1-2 N0 lung adenocarcinoma. We then investigated the expressions of three biomarkers using immunohistochemical analyses and compared the expression levels ...
Tópico(s): Peptidase Inhibition and Analysis
2017 - Dove Medical Press | Cancer Management and Research
Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata,
Tópico(s): Lung Cancer Research Studies
2017 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata,
We performed an analysis to clarify differences in clinicopathological and molecular features of lung invasive mucinous adenocarcinoma (IMA) based on computed tomography (CT) findings and their impact on prognosis.On the basis of CT findings, we divided lung IMA into three subtypes: solid, bubbling, and pneumonic. We then investigated differences in clinicopathological characteristics, prognosis, and the expressions of well-identified biomarkers, including cyclooxygenase-2 (Cox-2), excision repair ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2016 - Dove Medical Press | OncoTargets and Therapy
Ai Maeda, Masao Nakata, Katsuhiko Shimizu, Takuro Yukawa, Shinsuke Saisho, Riki Okita,
Pneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several chemotherapeutic agents and molecular targeted therapy agents are reported to be associated with PI, there have been few reports describing the association between the anti-epidermal growth factor receptor agent gefitinib, a tyrosine kinase inhibitor (TKI), and PI. The present report describes ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - BioMed Central | World Journal of Surgical Oncology
Riki Okita, Takuro Yukawa, Yuji Nojima, Ai Maeda, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata,
Tópico(s): Immunotherapy and Immune Responses
2016 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Riki Okita, Katsuhiko Shimizu, Yuji Nojima, Takuro Yukawa, Ai Maeda, Shinsuke Saisho, Masao Nakata,
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). It was reported that the tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular cytotoxicity (ADCC) in HER2-positive breast cancer, suggesting that this combination is a promising strategy for MPM treatment. The aim of the present study was to explore the possibility ...
Tópico(s): HER2/EGFR in Cancer Research
2015 - Elsevier BV | Oncology Reports
Katsuhiko Shimizu, Takuro Yukawa, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata,
Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now the standard of care based on large-scale phase III trials and a meta-analysis. However, chemotherapy has plateaued in terms of its efficacy, and the search for treatment prediction biomarkers is imperative for the further identification of treatable subgroups. Therefore, we investigated the significance of cyclooxygenase-2 (Cox-2) expression and the applicability of a Cox-2 inhibitor in patients who ...
Tópico(s): Peptidase Inhibition and Analysis
2015 - BioMed Central | World Journal of Surgical Oncology
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Takuro Yukawa, Ai Maeda, Yuji Nojima, Masao Nakata,
Background: Adjuvant chemotherapy after the complete resection of non-small-cell lung cancer (NSCLC) is now the standard of care. To improve survival, it is important to identify risk factors for the continuation of adjuvant chemotherapy. In this study, we analyzed chemotherapy compliance and magnitude of the prognostic impact of the prognostic nutritional index (PNI) before adjuvant chemotherapy. Methods: We conducted a retrospective review of data from 106 patients who had received adjuvant chemotherapy. ...
Tópico(s): Head and Neck Cancer Studies
2015 - Dove Medical Press | Therapeutics and Clinical Risk Management
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Takuro Yukawa, Ai Maeda, Yuji Nojima, Masao Nakata,
The maximal standardized uptake value (SUVmax) of pulmonary lesions on dual-time-point (DTP) fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for differentiation between malignant and non-malignant pulmonary lesions, and also to be of value for intrathoracic nodal staging of non-small cell lung cancer (NSCLC). However, a few NSCLC lesions have been found to show decreased FDG uptake on delayed images, and the significance of this finding remains unknown.We conducted ...
Tópico(s): Lung Cancer Treatments and Mutations
2015 - Springer Nature | Annals of Nuclear Medicine
Riki Okita, Wolf Diana, Koichiro Yasuda, Ai Maeda, Takuro Yukawa, Shinsuke Saisho, Katsuhiko Shimizu, Yoshiyuki Yamaguchi, Mikio Oka, Eiichi Nakayama, Andreas Lundqvist, Rolf Kiessling, Barbara Seliger, Masao Nakata,
Introduction Several cytotoxic anticancer drugs inhibit DNA replication and/or mitosis, while EGFR tyrosine kinase inhibitors inactivate EGFR signalling in cancer cell. Both types of anticancer drugs improve the overall survival of the patients with non-small-cell lung cancer (NSCLC), although tumors often become refractory to this treatment. Despite several mechanisms by which the tumors become resistant having been described the effect of these compounds on anti-tumor immunity remains largely unknown. ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2015 - Public Library of Science | PLoS ONE
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata,
The immunological status, consisting of "inflammation status" and "nutritional condition," is important for the survival of patients with various cancers, including non-small cell lung cancer (NSCLC). The neutrophil/lymphocyte ratio (NLR) reflects the inflammation status, and the prognostic nutritional index (PNI) reflects the immunological nutritional condition. In the present study, the correlation between the NLR and the PNI as well as the consistency and magnitude of the prognostic impact of the ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2015 - BioMed Central | World Journal of Surgical Oncology
Katsuhiko Shimizu, Yuji Hirami, Shinsuke Saisho, Takuro Yukawa, Ai Maeda, Koichiro Yasuda, Masao Nakata,
The purpose of this study is to clarify the correlations between the expression of membrane-bound estrogen receptor-α (mERα) and epidermal growth factor receptor (EGFR) mutation and clinicopathological factors, especially in relation to the prognosis, in patients with lung adenocarcinoma. We conducted a retrospective review of the data of 51 lung adenocarcinoma patients with tumors measuring less than 3 cm in diameter. Immunohistochemical staining for mERα expression and detection of the EGFR mutation ...
Tópico(s): HER2/EGFR in Cancer Research
2012 - BioMed Central | World Journal of Surgical Oncology
Ai Maeda, Masao Nakata, Koichiro Yasuda, Takuro Yukawa, Shinsuke Saisho, Riki Okita, Yuji Hirami, Katsuhiko Shimizu,
Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. Several studies have reported that genomic VEGF polymorphisms may influence VEGF synthesis. To evaluate the role of VEGF single nucleotide polymorphisms (SNPs), we examined the expression of several angiogenesis-related proteins [VEGF, hypoxia-inducible factor-1α (HIF-1α) and delta-like ligand 4 (Dll4)] and the spread of microvessels in resected non-small cell lung cancer (NSCLC). Blood and tumor tissue from 83 patients ...
Tópico(s): Cancer-related molecular mechanisms research
2012 - Elsevier BV | Oncology Reports
Katsuhiko Shimizu, Takuro Yukawa, Yuji Hirami, Riki Okita, Shinsuke Saisho, Ai Maeda, Koichiro Yasuda, Masao Nakata,
Tópico(s): Colorectal Cancer Treatments and Studies
2012 - Adis, Springer Healthcare | Targeted Oncology
Katsuhiko Shimizu, Masao Nakata, Yuji Hirami, Takuro Yukawa, Ai Maeda, Kazuo Tanemoto,
Cyclooxygenase-2 (COX-2) is constitutively overexpressed in a variety of epithelial malignancies and is usually associated with a poor prognosis. COX-2-derived prostaglandin E2 transforms CD4+CD25+ T regulatory (Treg) cells (Tregs), and Tregs are thought to moderate the antitumor immune response. Herein, we investigated the prognostic value of tumor-infiltrating Treg cells and their correlation with COX-2 expression in resected non-small cell lung cancer (NSCLC).Intratumoral COX-2 and Treg expression ...
Tópico(s): Chemokine receptors and signaling
2010 - Elsevier BV | Journal of Thoracic Oncology
Guang Hong, Takeshi Maeda, Ying-Ai Li, Shinsuke Sadamori, Taizo Hamada, Hiroshi Murata,
The purpose of this study was to determine the effect of PMMA polymer on dynamic viscoelasticity and plasticizer leachability of PEMA-based tissue conditioners. One PEMA polymer and one PMMA polymer were used in powder form with four formulations. The combination of 80 wt% ATBC, 15 wt% BPBG and 5 wt% ethyl alcohol was used as the liquid phase. The dynamic viscoelasticity and plasticizer leaching of each specimen were measured after 0, 1, 3, 7, and 14 days of immersion (37°C distilled water) using ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2010 - Japanese Society for Dental Materials and Devices | Dental Materials Journal