Andrew Robson, J. E. Holborn, Dr D. Zuck, Andrew Billen, Matthew Syed, Neelam Verjee, Tim Albone, Greg Hurst Political Correspondent, Frances Gibb Legal Editor, Gary Duncan, Magnus Linklater, James Harding, David Rose, Alexandra Frean Education Editor, Michael Evans Defence Editor, David Chater, James Ducker, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Gabrielle Starkey, Carl Mortished, Will Pavia, Sam Marlowe, James Hider, Musa Okwonga, Lucy Bannerman, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, David Sharrock, Sathnam Sanghera, Pat Gibson, Frieda Hughes, Jane MacArtney, Siobhan Kennedy, Tom Bawden, Gary Jacob, Trevor Leigh, Melanie Reid, Rosemary Bennett, Sir Adrian, Brenda Rolls, Randhir Singh Bains, Jenny MacArthur, Anatole Kaletsky, Gerry Hanson, Rhys Blakely, Richard Lloyd Parry, Helen Rumbelow, Robert Eddison, Norman Hammond Archaeology Correspondent, Derwent May, Gary Duncan Economics Editor, David Lister, Mark Henderson Science Editor, Tom Baldwin, Pete Paphides, Louisa Barnett, Eve Thomas, Paul McKenna, Rob Wright, Geoffrey Dean, David Watts, Alice Olins, Edward Gorman Motor Racing Correspondent, Jeff Immelt, Neil Harman Tennis Correspondent, Raymond Keene, Jeremy Roussak, Adam Sage, Christine Buckley, Lewis Smith, Matthew Pryor, K. N. Harris, Sean O'Neill, Dr Tanya Byron, Lewis Smith Environment reporter, Kaveh Solhekol, Peta Bee, Chris Campling, Cathy Harris, Hattie Garlick, Richard Owen, Richard Mangnall, JP Past Chairman, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Peter Dixon, Graham Matthews, David Hands Rugby Correspondent, Tom Dart, Julian Muscat, Paul Simons, Adam Fresco, William Rees-Mogg, Dominic Kennedy, Carole Souter Director, Steve Hawkes, Tim Hames, Dominic Maxwell, Mike Rosewell, Anjana Ahuja, Chris Dillow, George Caulkin, Alison Steed, Siobhan Kennedy M&A Correspondent, Caitlin Moran, Neil Fisher, Peter Riddell, Rob Tomlinson, Brian Clarke, Rajeev Syal, Derek Davies, Bojan Pancevski, Mark Henderson, Lewis Smith Environment Reporter, Christopher Irvine, Lisa Verrico, Alex Murphy, Patrick Foster, Benedict Nightingale, Judith Heywood Deputy Property Editor, Stephen Dalton, Bill Edgar, Frances Gibb, Julian de Jonquieres, Michael Evans, Alexandra Blair Education Correspondent, Olav Bjortomt, Nicola Copping, Guy Shirra, Elizabeth Judge Telecoms Correspondent, The Rev Dr Anthony J. Carr,
... clean sweep Wolverhampton Big-race result Tennis The Aidan O'Brien-trained Anton Chekhov finished third Index ... Shots Yakubu Suitors Form a Queue The News Quinn Places the Onus on Sunderland's Home Advantage ...
2007 - Gale Group | TDA
Lucia Morgado-Palacin, Jessie Brown, Thomas F. Martínez, Juana M. García–Pedrero, F. Forouhar, S. Aidan Quinn, Clara Reglero, Joan Vaughan, Yasamin Hajy Heydary, Cynthia J. Donaldson, Sandra Rodríguez, Eva Allonca, Rocío Granda‐Díaz, Agustín F. Fernández, Mario F. Fraga, Arianna L. Kim, Jorge Santos‐Juanes, David M. Owens, Juan P. Rodrigo, Alan Saghatelian, Adolfo A. Ferrando,
Abstract The TINCR ( T erminal differentiation- I nduced N on- C oding R NA) gene is selectively expressed in epithelium tissues and is involved in the control of human epidermal differentiation and wound healing. Despite its initial report as a long non-coding RNA, the TINCR locus codes for a highly conserved ubiquitin-like microprotein associated with keratinocyte differentiation. Here we report the identification of TINCR as a tumor suppressor in squamous cell carcinoma (SCC). TINCR is upregulated ...
Tópico(s): NF-κB Signaling Pathways
2023 - Nature Portfolio | Nature Communications
Jeffrey Ewener, Alexander Birchley, Waldemar Januszczak, John Dugdale, Michael Prescott, Jane Cornwell, Mark Stretton, Diane Kirk, Jeff Dawson, Valerie Thompson, James Clark, Kenny Farquharson, Kevin Wheatley, Rob Hughes, John Peter, Ann Smith, Richard Warren, Nigel Lowey, Tom Erskine, J C, Amanda Ursell, Jonathan Miller, Emma Moore, John Porter, Rodney Leach, Andy Walsh, Susan d'Arcy, Mark Souster, J D, Max Glaskin, Bert Maile, Ivo Tennant, James Nunn, Maureen Crosbie, Kathryn Cooper, David Smith, Kirstie Hamilton City Editor, Alastair McCall, Humphrey Carpenter, Jonathan Roberts, Rory Godson, Lucy Irvine, Melanie Phillips, N Fish, Andrew Meldrum, Andrew Sullivan, Michael Thrasher, Tom Mercer, David Pirie, Mary Wilson, Timothy McVeigh, Mike Moran, Mrs I H Young, Kathy Brewis, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Anthony Sattin, Phil Smith, Robert Winnett, Irwin Stelzer, Jane Moore, Anthony Seldon, Peter Wilson, Mark Ottaway, Mick Rix, Lawrence Dallaglio, Jon Furmston, Ian Richards, Anna Bruning, Max Seligman, John Waples Deputy Business Editor, Thrasy Petropoulos, Geraldine Hackett, Sarah Toyne, Mark Hunt, David Hewson, Glare Gordon Smith, Jonathon Carr-Brown, Hugh Mcllvanney, Alasdair Reid, Margarette Driscoll, Colin Mehigan, Jeremy Clarkson, Peter Watson, Edward Porter, Peter Conradi, Stewart Lee, Louise Taylor, Jason Bell, Max Anderson, David Rickford, Cheryl Markosky, Gwen Harlow, Eben Black, Robert Harris, Brian Spink, James Parker, John O'Donnell, Nigel Wylde, Lydia Slater, Andrew Cunningham, Michael Crowley-Milling, Adam Nathan, Victoria Hervey, Nick Gardner, Paul Bailey, Peter Johnstone, Richard Johnson, Stuart Wavell, Roger Eglin, Stella Bingham, Paul Donovan, Maggie Gee, Keith Wilkinson, Frances Spalding, Maxwell Hutchinson, Christiaan Barnard, Hugh McIlvanney, Simon Mills, Mike Acton, Lucinda Kemeny, Jasper Gerard, Colin Hannaford, Michael Woodhead, Paul Driver, Ann McFerran, John Follain, Nicholas Hellen, Richard Brooks, Peter Windsor, Shelley Von Strunckel, Stuart Andrews, Jacqui Ripley, Martin May, Christopher Morgan, David Leppard, Paul Durman, Amber Cowan, Paul Trueman, Walter Grey, Mark Edwards, Kirstie Hamilton, Jim Brown, Sarah Gracie, Susan Clark, Mel Brooks, Danny O'Brien, Hugh Canning, Michael Riding, Phil Baker, Hugo Barnacle, Charly Durrant, Lois Rogers, Tony Small, Dr Eric Colman, Douglas Alexander, Janet Jones, Ian Phillips, Senay Boztas, Cosmo Landesman, Andrew Roberts, Robbie Hudson, Dave Baron, Diana Wright, Elaine Showalter, Stephen Jones, Richard Evans, Uzi Mahnaimi, Nick Cain, Pete McCarthy, K W Woznica, Natalie Graham, Paul Nuki, Sumner Smith, M J, Caroline Donald, Kate Rew, John Burridge, Rob Ryan, Keith Wheatley, Miranda Seymour, David Walsh, Caroline Gascoigne, John Stern, Tiffanie Darke, Bryan Appleyard, Lois Rogers Medical Correspondent, Adrian Weale, Rod Barrett, Mark Macaskill, R W Johnson, Roland White, Rory Godson Business Editor, Marcello Mega, Anita Roddick, Nayab Chohan, Maurice Chittenden, Alex Fortune, Richard Brooks Arts Editor, Mary Jenkins, Richard Rae, Ray Hutton, Frank Fitzgibbon, Frankfurt, Martin Ivens, Nancy McGrath, Kevin Sharpe, Jonathan Leake, Michael Sheridan, Michal Prescott, Godfrey Smith, John Urbanek, Barry Collins, Gillian Wilmot, A A Gill, Matthew Campbell, Helen Pugh, Brian Glanville, Allan Pace, Chloe Beeney, Harvey Jones, Gareth Alexander, Stephen Pettitt, Claudia Croft, Lauren St John, Trushar Barot, Cherry Norton, Annie Mills, Jeremy Langmead, Tom Walker Diplomatic Correspondent, Chris Rea Communications Manager, Liam Clarke, Nicholas Hellen Media Editor, David Wickers, Clifford Bishop, John Kedar, Andrew Frankel, Graham Norwood, Joe Lovejoy, Colin Rallings, Rupert Steiner, Tom Parker, Hugh Pearman, Dan Cairns, David Blunkett Home Secretary, Simon Sebag Montefiore, David Grylls, Francis Oakley, Esme Floyd, David Smith Economics Editor, Simon Trump, Bob Dwyer, Carey Scott, Joanna Simon, India Knight, Steve Grant, Simon Howard, Danny Danziger, Damian Rogers, Dan Pearson, Lisa Verrico, Dominic Rushe, Gabriella Bianchi, Karen Robinson, B A Rootes,
... brought triumph for 'the new Master of Ballydoyle', Aidan O'Brien England focus on New spirit of ... The tabloid week Talking heads The Times: Anthony Quinn Chenjerai Hunzvi People of the Week This Life ...
2001 - Gale Group | Sunday Times HA GDA
Anup Biswas, Seo-Young Han, Yifan Tai, Wanchao Ma, Courtney Coker, S. Aidan Quinn, Ahmad Rushdi Shakri, Timothy James Zhong, Hanna Scholze, Galina G. Lagos, Angeliki Mela, Katia Manova–Todorova, Elisa de Stanchina, Adolfo A. Ferrando, Cathy Mendelsohn, Peter Canoll, Helena A. Yu, Paul K. Paik, Anjali Saqi, Catherine A. Shu, Mark G. Kris, Joan Massagué, Swarnali Acharyya,
Abstract The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib has significantly prolonged progression-free survival (PFS) in patients with EGFR-mutant lung cancer, including those with brain metastases. However, despite striking initial responses, osimertinib-treated patients eventually develop lethal metastatic relapse, often to the brain. Although osimertinib-refractory brain relapse is a major clinical challenge, its underlying mechanisms remain poorly understood. ...
Tópico(s): Ferroptosis and cancer prognosis
2022 - American Association for Cancer Research | Cancer Discovery
Teresa Poole, Miles Kington, Martin Baker, Patricia Davies, Keith Dalton, Hazhir Teimourian, Peter Marson, John Hollis, Michael Clark and Carol Leonard, J. A. Dukes, Geraldine Norman, Sale Room Correspondent, Robin Oakley, John Bell, City Editor, Hilary Finch, Ian Murray, Richard Streeton, Richard Eaton, Stuart Jones Football Correspondent, Gerald Davies, Howard Foster, Brian James, Edward Frewin Managing Director, Mitchell Platts, David Puttnam, Mohsin Ali, Lawrence Lever, Christopher Davalle, Robin Young, Martin Cropper, Martin Fletcher, Political Reporter, Michael Hamlyn, Richard Evans, Political Correspondent, Tom Rice National Secretary, John Percival, Richard Thomson, Banking Correspondent, Rex Bellamy, Tennis Correspondent, Fiona MacCarthy, John Hennessy, John Young, Agriculture Correspondent, Martin Fletcher Political Reporter, Una Mills, Harvey Elliott, Air Correspondent, C. P. Crosby, David Cross, Sydney Friskin, Nicholas Harling, David Miller, Robin Oakley Political Editor, Philip Webster, Chief Political Correspondent, (Michael Phillips), John Nicholson, David Watts, Nicholas Wood Political Reporter, Trudi McIntosh, Alison Eadie, David Robinson, Nicholas Beeston, Paul Griffiths, Stewart Tendler Crime Reporter, Graham Dow, Craig Seton, PHS, Richard Owen, Keith Wheatley, Irving Wardle, Roger Boyes, Ian Taylor Chairman, Ronald Butt, Eduardo Cué, Richard Bassett, Sheila Gunn Political Staff, Keith MacKlin, William Douglas Home, David Hands Rugby Correspondent, Kenneth Fleet, Christopher Thomas, John Goodbody, John England, Ian Smith, Anne Campbell Dixon, Wayland Kennet, Neil Lyndon, Christopher Walker, Carol Ferguson, Clive White, Judith Cruickshank, Michael Hartnack, Michael Hornsby, Robert Grieves, Peter Dear, Stephen Pettitt, Tim Jones, Evan Luard, Derek Harris, Bailey Morris, Philip Howard, Literary Editor, Robert Fisk, Rodney Lord, Economics Editor, Richard Morrison, Adriana Matheson, Derek Harris Industrial Editor, John Campbell, Michael Evans, Pearce Wright, Science Editor, Eldon Griffiths, Colin McQuillan, Rodney Lord Economics Editor, Kenneth Fleet Executive Editor,
... Dibdin Cape, £9.95 Kin By John Murray Aidan Ellis, £9.95 Patrick Leigh Fermor The Dirty ...
1986 - Gale Group | TDA
José R. Cortés, Ioan Filip, Robert Albero, Juan Ángel Patin͂o-Galindo, S. Aidan Quinn, Wen-Hsuan W. Lin, Anouchka P. Laurent, Bobby B. Shih, Jessie Brown, Anisha J. Cooke, Adam L. Mackey, Jonah Einson, Sakellarios Zairis, Alfredo Rivas‐Delgado, Maria Antonella Laginestra, Stefano Pileri, Elı́as Campo, Govind Bhagat, Adolfo A. Ferrando, Raúl Rabadán, Teresa Palomero,
Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) comprises heterogeneous lymphoid malignancies characterized by pleomorphic lymphocytes and variable inflammatory cell-rich tumor microenvironment. Genetic drivers in PTCL-NOS include genomic alterations affecting the VAV1 oncogene; however, their specific role and mechanisms in PTCL-NOS remain incompletely understood. Here we show that expression of Vav1-Myo1f, a recurrent PTCL-associated VAV1 fusion, induces oncogenic transformation of ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - Cell Press | Cell Reports
Andrew Robson, Matt Dickinson Chief Sports Correspondent, Gabriele Marcotti, Andrew Billen, Michael S. Howells, Gary Duncan, Simon Barnes, Robin Pagnamenta Energy and Environment Editor, John Hughes, Mark Souster, David Rose, Ian Winrow, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Christine Seib, David Chater, James Bone, James Ducker, Penny Wark, Richard Hobson One-Day Cricket Correspondent, Richard McDonald, Geoff Brown, Martin Samuel Chief Football Correspondent, Joe Joseph, Robin Pagnamenta, Ben Webster Transport Correspondent, Frieda Hughes, Rob Crilly, Hannah Fletcher, Siobhan Kennedy, Tom Bawden, Dan Sabbagh Media Editor, Debra Craine, Melanie Reid, Peter Stiff, Tim Reid, Rosemary Bennett, Richard Blandy, David Hunter, Richard Ford Home Correspondent, Bridget Frust, Jenny MacArthur, Charles Bremner, John Zarocostas, Ron Lewis, Stefanie Marsh, Peter Chatfield, Barbara Stocking, Norman Hammond Archaeology Correspondent, Derwent May, Angela Jameson, Russell Kempson, Terence Kealey, Suzy Jagger, Gary Duncan Economics Editor, Oliver Kay, Gerard Baker, David Lister, Mark Henderson Science Editor, Enid Hughes, Callum Roberts, John Westerby, Rick Broadbent, Ben Quinn, Sheera Frenkel, John Hopkins Golf Correspondent, Rob Wright, Alice Olins, Alun Jones, Martin Samuel, Raymond Keene, Lewis Smith, Matthew Pryor, Rebecca O'Connor, Christine Buckley Industrial Editor, Martin Murrell, Dr Tanya Byron, Kaveh Solhekol, Jeremy Page, Ginny Roberts, Jerry Diccox, Planet Jupitus, David Malaperiman, Richard Owen, Lauren Bacall, David Clement, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Julian Muscat, Paul Simons, Nigel Kendall, William Rees-Mogg, Anne Ashworth, Dominic Kennedy, Nick Szczepanik, Philip Webster Political Editor, D. W. Laing, Tim Hames, Thomas Catán, Craig Lord, Dominic Maxwell, George Caulkin, Caitlin Moran, Alan Lee, John Pincham, Walter Gammie, Jeremy Page South Asia Correspondent, Philip Webster, David Sanderson, David Sinclair, Samantha Ball, Lewis Stuart, Catherine Philp, Martin Waller, Patrick Foster, Sara Tait, Benedict Nightingale, Rick Broadbent Athletics Correspondent, Stephen Dalton, Ben Hoyle, Leo Lewis, Bill Edgar, Frances Gibb, Alyson Rudd, Roger Bush, Judith Heywood, Olav Bjortomt, Fiona Hamilton, David Robertson, Richard Ford, Lisa Verrico, Rebecca Goldsmith, Stephen Pollard,
... Brighton Yesterday's results Newton Abbot Index The Aidan O'Brien-trained US Ranger, a 4-5 ...
2008 - Gale Group | TDA
Christine S. Moon, Clara Reglero, José R. Cortés, S. Aidan Quinn, Silvia Álvarez, Junfei Zhao, Wen-Hsuan W. Lin, Anisha J. Cooke, Francesco Abate, Craig R. Soderquist, Claudia Fiñana, Giorgio Inghirami, Elı́as Campo, Govind Bhagat, Raúl Rabadán, Teresa Palomero, Adolfo A. Ferrando,
Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma not otherwise specified (PTCL, NOS) have poor prognosis and, in most cases, lack driver actionable targets for directed therapies. Here we identify FYN–TRAF3IP2 as a recurrent oncogenic gene fusion in AITL and PTCL, NOS tumors. Mechanistically, we show that FYN–TRAF3IP2 leads to aberrant NF-κB signaling downstream of T-cell antigen receptor activation. Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic ...
Tópico(s): Ubiquitin and proteasome pathways
2021 - Nature Portfolio | Nature Cancer
Julle Cohen, Waldemar Januszczak, John Dugdale, John Coleman, Robert Irwin, Mark Searle, Barbara Hall, Edward Owen, Jillie Murphy, Ian Chadiband, Julian Keeling, Eileen Lynch, Jim Munro, Kenny Wiwa, John Peter, Paul Harris, Emma Moore, Mark Reason, Jonathan Miller, Norman MacRae, Laurence Purcell, Lord Waddington Governor, Christopher Somerville, Susan d'Arcy, Max Glaskin, Joanna Duckworth, Nick Rufford, Jason Burke, Graham Rose, Sheridan Morley, Ned Balfe, Christa D'souza, Julia Dodd, Iain Martin, Alistair Scott, Laura Thompson, Sally Payne, David Smith, Sean Ryan Environment Correspondent, Professor Akbar Ahmed Centre of South Asian Studies, Sean Ryan Science Correspondent, Charles Hymas, Sebastian Hamilton, Edward Welsh, Bob Wootton, Edward Platt, Annabel Heseltine, Geordie Greig, Tony Allen-Mills, Martin James, Robert Sandall, Albert Greendale, Irwin Stelzer, Robert Hewison, Peter Wilson, Sidney Montlake, Deryk Brown, Roger Anderson, Mick Brown, David Dougill, Mangosuthu Buthelezi, John Evans, Robert Turnbull, Liz Deegan, Harvey Porlock, Randeep Ramesh, Margaret Coles, Hugh Canning, Margarette Driscoll, Hugh Mcllvanney, Alasdair Reid, Jeremy Clarkson, Louise Taylor, Richard Fairbairn, Joan Nurse, Sean Ryan, Geoff Whitten, Jeannette Kupfermann, Simon Hinde, Simon Wertheimer, Richard woods, Adam Courtenay, George Browning, George Perry, Cathy Scott-Clark, Simon Baker, Mark Skipworth, Pam Barren, Shelley von Strunckel, Norman Lamont, Peter Warren, Ardyn Bernoth, Sabine Durrant, Christine Toomey, Rob Steen, Tina Gaudoin, Bernard Cafferty, Paul Ham, Paul Donovan, Alan Smithers, Philip Craigle, Sue Lawrence, Jeff Randall, James Bethell, Paul Driver, James Adams, Simon Fanshawe, Dr Dylan Wiliam King's College, David Thomas, Liz Lightfoot, Harvey Cole, Ian Chadband, Richard Bath, David Leppard, Oleg Gordievsky, Kevin Conneilly, Richard North, John Fowles, Kirstie Hamilton, Mark Edwards, Rufus Olins, Betty Bonavia, Graham Lidstone, Dave Thomas, Frances Kennedy, S C Coleman, Phil Baker, Christopher Lloyd, Katharine Hadley, Christina Lamb, Simon Harrison, John Karter, Kate Saunders, Cosmo Landesman, Andrew Roberts, Diana Wright, Frank Kane, Stephen Jones, Andrew Grice Chief Political Correspondent, Liz Lightfoot Legal Affairs Correspondent, Heather Kirby, Andrew Neil, Paul Nuki, Andrew Grice, Julie Cohen, Colin Hobbs, Martin Searby, Fraser Harrison, Ian Critchley, Anthony Quinn, Colin McDowell, Ian Burrell, Louise Evans, Gillian Gribbs, Richard Woods, David Windle, Garth Alexander, John Cuthbert, Peter Johnson, Rachel Cooke, Antony Worrall Thompson, Roland White, Maurice Chittenden, John Heuston, Barry Pickup, Robin Robertson, Ray Hutton, Julie Burchill, Rebecca Fowler, Michael Jones Political Editor, David Hunn, Brian Walker, Mihir Bose, Jonathan Rendall, Matthew Lynn, Godfrey Smith, Lesley Thomas, Jane Scott, Nick Harling, Richard Pembroke, Gail Ingram, Lucie Young, Andrew Alderson, John Waples, Jonathan Ross, A A Gill, Nick Farr-Jones, Andrew Malone, Isobel Bechka, Rajeev Syal, Winner's Dinners, Chrissy Iley, Lauren St John, Stephen Pettitt, Denise Kingsmill, Gwynneth Hughes, Gilbert Adair, Andrew Lorenz, Sean O'brien, Jean MacKenzie, Adrian Levy, Sylvia Turner, David Wickers, Matthew F W Taylor, Denis Healey, Steven Mear, Nicholas Hellen Media Correspondent, Paula Quirk, Joe Lovejoy, Christopher Higgins, Rupert Steiner, John Cole, Chris Lightbown, Hugh Pearman, Paula Reed, Simon Sebag Montefiore, Neil MacLean, Hugh Bradley, Sarah Baxter, Martin Booth, Jaci Stephen, Walter Ellis, Joanna Simon, Michael Dixon, Sophie Grigson, Dan Pearson, Boris Schapiro,
... Union Rugby League Another O'Brien makes good Aidan O'Brien, the trainer breaking all records in ...
1995 - Gale Group | Sunday Times HA GDA
José R. Cortés, Christina C. Patrone, S. Aidan Quinn, Yuhan Gu, Marta Sánchez-Martín, Adam L. Mackey, Anisha J. Cooke, Bobby B. Shih, Anouchka P. Laurent, Megan H. Trager, Adolfo A. Ferrando, Larisa J. Geskin, Teresa Palomero,
Sézary syndrome is an aggressive and disseminated form of cutaneous T-cell lymphoma associated with dismal prognosis in which the histone deacetylase inhibitor romidepsin has shown remarkable activity as a single agent. However, clinical responses to romidepsin are typically transient, highlighting the need for more effective therapies. In this study, we show synergistic antilymphoma effects of romidepsin in combination with mechlorethamine, an alkylating agent, in cutaneous T-cell lymphoma cell ...
Tópico(s): T-cell and Retrovirus Studies
2021 - Elsevier BV | Journal of Investigative Dermatology
Andrew Robson, Tim Reld, Janine Dl Glovannl, Jon Ashworth, Raymond Snoddy Media Editor, Matthew Bannister, Andrew Pierce, James Moore, Grace Bradberry, Sarah Potter, Frances Gibb Legal Editor, Michael House, Simon Barnes, Robert Thicknesse, Tim Judah, Paul Hoggart, Peter Cash, Roy Evans, Richard Hobson, Martin Richards, Ivo Tennant, W. A. Stubbles, Willie Petrie, Marcus A. Roberts, Philip Howard, Carol Midgley, Melanie Rickey, Noel Buchanan, Vincent Lovegrove, Roger Sawyer, David Chater, Michael Binyon, Joanna Bale, Malcolm K. Savidge, Alexandra Frean Social Affairs Correspondent, Patrick Phillips, Elizabeth Judge, Richard Owen and Daniel McGrory, Jethryn Hall, Clive Matheson, Kevin Eason, Raymond Snoddy, Giles Coren, John O'Leary Education Editor, Mike Williams, Antonia Senior, Martin Fletcher, Ben Webster Transport Correspondent, Cornelius Lysaght, Dominic Walsh, Russell Kempson and Oliver Kay, Alix Ramsay Tennis Correspondent, Mary Ann Siegbart, Lawrence James, John Tribe, Richard Ford Home Correspondent, Robin Young, Mike Rosewell Rowing Correspondent, Rodney Milnes, Jenny MacArthur, James Delingpole, Alice Lagnado, Kathleen Waytt, David Hands, Charles Bremner, Michael Joy, Mark Court, Clive Mathieson Telecoms Correspondent, Nicholas Wapshott, Angela Jameson, Russell Kempson, Sarah Bradford, Michael J. Hendrie Astronomy Correspondent, David Lister, Rick Broadbent, Winifred Tumim, John Hopkins, Marit Hargie, Peter Tray, Lord Hanson, John Hopkins Golf Correspondent, David Powell Athletics Correspondent, Raymond Keene, Adam Sage, Daniel Wallis, Martin Fletcher European Correspondent and Dragan Petrovic, Bernard Coe, Alix Ramsay, Angela Jameson and Phillp Webster, Oliver Holt, Richard Owen, Damian Whitworth, Roger Boyes, Nick Hasell, David Hands Rugby Correspondent, Julian Muscat, Adam Fresco, Michael Evans Defence Editor and Ben Macintyre, Martin Fletcher European Correspondent, James Doran and Kate Messer, Mike Mulvihill, Nick Szczepanik, John Goodbody, Dominic Kennedy, Terence Morris, Brian MacArthur, Matthew Parris, Graham Searjeant Financial Editor, Raymond snoddy Media Editor, Cerys Matthews, Peter Riddell, Alex Benady, Ben Webster, Ben Macintyre, Steve J. Taylor, Simon Jenkins, David Sinclair, Gary Duncan Economics Correspondent, Martin Waller, Chris Ayres, Laura Peek, Benedict Nightingale, Misha Glenny, Stephen Dalton, Alyson Rudd, Richard Morrison, Sam Kiley, Gavin Littaur, John Cottrell, Nicholas Lane, Alan Lee Racing Correspondent, Sally Patten, Roland Watson Chief Political Correspondent, Eldon Griffiths, F. P. Dilkes, Philip Webster and Melissa Kite, Sally Patten Retail Correspondent, Lisa Verrico, Aidan Channer, Joanna Coles,
... Goodwood Folkestone Stratford Yesterday's results TEAMtalk Race Quinn loses licence until 2004 Racing Today's sports ...
2001 - Gale Group | TDA
Koichi Oshima, Junfei Zhao, Pablo Pérez‐Durán, Jessie Brown, Juan Ángel Patin͂o-Galindo, Timothy Chu, S. Aidan Quinn, Thomas Gunning, Laura Belver, Alberto Ambesi‐Impiombato, Valeria Tosello, Zhengqiang Wang, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Milagros Balbı́n, Concepción Nicolás, Julie M. Gastier‐Foster, Meenakshi Devidas, Mignon L. Loh, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Mark D. Minden, Jules P.P. Meijerink, Raúl Rabadán, Adolfo A. Ferrando,
Multiagent combination chemotherapy can be curative in acute lymphoblastic leukemia (ALL). Still, patients with primary refractory disease or with relapsed leukemia have a very poor prognosis. Here we integrate an in-depth dissection of the mutational landscape across diagnostic and relapsed pediatric and adult ALL samples with genome-wide CRISPR screen analysis of gene–drug interactions across seven ALL chemotherapy drugs. By combining these analyses, we uncover diagnostic and relapse-specific mutational ...
Tópico(s): Cancer therapeutics and mechanisms
2020 - Nature Portfolio | Nature Cancer
Andrew Robson, Aidan Magee, Andrew Billen, Robert Cole, Matthew Syed, Bel Mooney, Neelam Verjee, David Brown, Greg Hurst Political Correspondent, Frances Gibb Legal Editor, Alexandra Blair, Magnus Linklater, Peter Lansley, James Harding, Mark Souster, David Rose, Michael Evans Defence Editor, Philip Howard, Lisa Amphlett, Christine Seib, David Chater, James Bone, Rachel Campbell-Johnston, Richard Hobson One-Day Cricket Correspondent, Rosalind Renshaw, Carl Mortished, Richard Eaton, Phyllis Chesler, Kevin Eason, Jessica Woodroffe Director, John Percy, Andrew Norfolk, Joe Joseph, Sameera Moledina, Lester May, Ben Webster Transport Correspondent, Pat Gibson, Rob Crilly, Stewart Tendler Crime Correspondent, Jack Malvern, Tom Bawden, Steve Bird, Dominic Walsh, Debra Craine, Kenneth Armitage, Rory Watson, Daniel Finkelstein, Tim Reid, Dr Nothemba Simelela Director, Dalya Alberge Arts Correspondent, Paul Malone, Chris Riley, Richard Ford Home Correspondent, Jenny Jones, Phil Gordon, Rhys Blakely, Charles Bremner, Adam Sherwin Media Correspondent, David Charter, Stuart Crainer, Peter Lewis, Hugo Rifkind, Derwent May, Russell Kempson, Gary Duncan Economics Editor, Oliver Kay, David Brooker, Sarah Vine, Lisa Armstrong, Patrick Hosking Banking and Finance Editor, James Harding Business Editor, Rick Broadbent, Tom Baldwin, James Rossiter, Sam Coates, John Hopkins, David Yendley, Ann Treneman, Simon de Bruxelles, Rob Wright, Chris Gibson-Smith Chairman, Edward Gorman Motor Racing Correspondent, Gabriel Rozenberg, Martin Samuel, Raymond Keene, Adam Sage, Christine Buckley, Lewis Smith, Peter Riddell Political Briefing, Matt Hughes, Matt Dickinson, Christine Buckley Industrial Editor, Steve Coomber, Kaveh Solhekol, Richard Lloyd Parry Asia Editor, Natalie Glock, Chris Campling, Fran Yeoman, Cathy Harris, Hattie Garlick, Jill Sherman, Richard Hawkes International Programmes Director, Monica Seeley, Nick Hasell, Grayson Perry, Ned Parker, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Julian Muscat, Paul Simons, Sarah Ivens, Hazel Davis, Kevin Maher, Anne Ashworth, Joanna Pitman, Neelima Mahajan, Philip Webster Political Editor, Steve Hawkes, Michele Kirsch, Des Dearlove, Anthony Browne Chief Political Correspondent, Anthony Arkell, Caitlin Moran, Anthony Loyd, Stephen Hoare, Richard Beeston Diplomatic Editor, Rajeev Syal, Philip Webster, Peter Jenson, David Sanderson, Jacqui Goddard, Jason Mellor, Martin Waller, Michael Horsnell, Alan Coren, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Ashling O'Connor, Lydia Hislop, Peter Lamberton, Dr Thomas Stuttaford, Stephen Dalton, Frances Gibb, Michael Evans, Alan Lee Racing Correspondent, Alexandra Blair Education Correspondent, Miles Costello, Jan Raath, Michael Brown, Jane Macartney, Bryce Elder, Joe Bolger, Ian Holloway, Christopher Irvine, Elizabeth Judge Telecoms Correspondent,
... Festival glory Racing Paul Moloney Fontwell Park John Quinn Course specialists Carberry's injury gives Meade anxious ...
2007 - Gale Group | TDA
Laura Belver, Alexander Yang, Robert Albero, Daniel Herranz, Francesco Brundu, S. Aidan Quinn, Pablo Pérez‐Durán, Silvia Álvarez, Francesca Gianni, Marissa Rashkovan, Devya Gurung, Pedro P. Rocha, Ramya Raviram, Clara Reglero, José R. Cortés, Anisha J. Cooke, Agnieszka A. Wendorff, Valentina Cordoʹ, Jules P.P. Meijerink, Raúl Rabadán, Adolfo A. Ferrando,
Long-range enhancers govern the temporal and spatial control of gene expression; however, the mechanisms that regulate enhancer activity during normal and malignant development remain poorly understood. Here, we demonstrate a role for aberrant chromatin accessibility in the regulation of MYC expression in T-cell lymphoblastic leukemia (T-ALL). Central to this process, the NOTCH1-MYC enhancer (N-Me), a long-range T cell-specific MYC enhancer, shows dynamic changes in chromatin accessibility during ...
Tópico(s): Genomics and Chromatin Dynamics
2019 - American Association for Cancer Research | Cancer Discovery
Andrew Robson, Alan Howden, Simon Barnes Chief Sports Writer, Gabriele Marcotti, Phil Yates, Aidan Magee, Justin Whiteley, Martin Sewell, Andrew Billen, Leo Lewis Asia Business Correspondent, Alexandra Frean, Gary Duncan, Amanda Ursell, Peter Lansley, Neil Barraclough, Richard Hobson, David Rose, Ian Winrow, Philip Howard, Hilary Finch, David Chater, Ben Hoyle Arts Reporter, Joanna Bale, James Bone, Jeremy Kingston, Penny Wark, James Ducker, Moritz Volz, Richard Hobson One-Day Cricket Correspondent, Leon Pollock, Elizabeth Judge, David E. Lowry, Angus MacLeod Scottish Political Editor, Sam Marlowe, William Wordsworth, Jeremy Whittle, Peter Megann, Kevin Eason, John Russell, Kapish Narda, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Ben Webster Transport Correspondent, Valerie Elliott Countryside Editor, Frieda Hughes, Siobhan Kennedy, Anthony Browne, Gary Jacob, Michael Harvey, Jen Redshaw, Dan Sabbagh, Chris Riley, Alan Hamilton, David Sharrock Ireland Correspondent, Anthony Rodriguez, Richard Lloyd Parry, Sadie Gray, David Hands, Adam LeBor, Ron Lewis, Guillem Balague, Adam Sherwin Media Correspondent, Tim Teeman, Jeremy Plester, Derwent May, Fan Gang, Eric Campbell, Roy Richardson, U. A. Fanthorpe, Russell Kempson, Adam Uren, Gary Duncan Economics Editor, Carola Long, Oliver Kay, Tony Rees, Neil Harman, Michael Theodoulou, G. Woods, Siobhan Kennedy Mergers and Acquisitions Correspondent, John Westerby, Stephen Burgen, Jonathan Clayton Africa Correspondent, Angela Murphy Pro-Vice-Chancellor, John Hopkins Golf Correspondent, Rob Wright, David Watts, Robin Pagnamenta Health Industries Correspondent, Bernard Lagan, Neil Harman Tennis Correspondent, Tony Evans, Raymond Keene, Christine Buckley, Matthew Pryor, Tom Stoppard, Matt Hughes, Bruce Dessau, Sean O'Neill, Dr Tanya Byron, Leslie Bennetts, Kaveh Solhekol, Sylvia Townsend Warner, Peta Bee, Jeremy Page, Chris Campling, Helen Nugent, Richard Owen, Laura Deeley, Christopher Martin-Jenkins Chief Cricket Correspondent, Francesca Steele, Peter Dixon, Nick Hasell, Stewart Tendler, David Hands Rugby Correspondent, Tony Cascarino, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Mira Bar-Hillel, William Rees-Mogg, Nick Szczepanik, Dearbáil Jordan, Steve Hawkes, Tim Hames, Craig Lord, Ian Johns, Anthony Browne Chief Political Correspondent, Mike Rosewell, Anjana Ahuja, George Caulkin, Sonia Verma, Caitlin Moran, Neil Fisher, Walter Gammie, Raoul Franklin Vice-Chancellor, Richard Beeston, Richard Beeston Diplomatic Editor, Alex Davidson, Bojan Pancevski, Catherine Philp, Danny Baker, Ashling O'Connor, Asif Khan, Dr Thomas Stuttaford, Adrian Dence, Stephen Dalton, Richard Morrison, Alyson Rudd, Bill Edgar, Adam Sherwin, Alan Lee Racing Correspondent, Alexandra Blair Education Correspondent, Olav Bjortomt, Brian Clarke Fishing Correspondent, Fiona Hamilton, Richard Ford, Ed Hughes, Christopher Irvine,
... Championship Wallace Strike Keeps Sunderland in the Ascendancy Quinn Plays Fare by Supporters Burnley (0) 0 Luton ( ...
2007 - Gale Group | TDA
Agnieszka A. Wendorff, S. Aidan Quinn, Marissa Rashkovan, Chioma J. Madubata, Alberto Ambesi‐Impiombato, Mark R. Litzow, Martin S. Tallman, Elisabeth Paietta, Maddalena Paganin, Giuseppe Basso, Julie M. Gastier‐Foster, Mignon L. Loh, Raúl Rabadán, Pieter Van Vlierberghe, Adolfo A. Ferrando,
Abstract The plant homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL); however, its specific functional role in leukemia development remains to be established. Here, we show that loss of PHF6 is an early mutational event in leukemia transformation. Mechanistically, genetic inactivation of Phf6 in the hematopoietic system enhances hematopoietic stem cell (HSC) long-term self-renewal and hematopoietic recovery after chemotherapy by rendering Phf6 knockout ...
Tópico(s): CAR-T cell therapy research
2018 - American Association for Cancer Research | Cancer Discovery
Richard Mabey, Andrew Robson, Matt Dickinson Chief Sports Correspondent, Amanda Andrews, Simon Barnes Chief Sports Writer, Gabriele Marcotti, Aidan Magee, Andrew Billen, Matthew Syed, David Brown, Alexandra Frean, Frances Gibb Legal Editor, Gary Duncan, Simon Barnes, Professor Gren Lucas Former keeper, Magnus Linklater, Paul Bompard, Peter Lansley, John Riseley, Mark Souster, David Rose, Alexandra Frean Education Editor, Philip Howard, Dai Jenkins, Jonny Wilkinson, David Chater, Ben Hoyle Arts Reporter, Baroness Nicholson of Winterboourne, Graham Anderson Professor of Classics, Penny Wark, Moritz Volz, Richard Hobson One-Day Cricket Correspondent, Gabrielle Starkey, simon Barnes, Patrick Kidd, David Charter Europe Correspondent, Sam Marlowe, Martin samuel, Martin Samuel Chief Football Correspondent, Dr Owen Plunkett, Joe Joseph, Alan Carr, Sir David Bellamy, Sathnam Sanghera, Frieda Hughes, Jane MacArtney, Valerie Elliott, Donald Hutera, Deborah Haynes, Ricky Tomlinson, Dominic Walsh, Debra Craine, Gary Jacob, Tim Reid, Dan Sabbagh, Dalya Alberge Arts Correspondent, Dr Caroline Lucas, Rajendra K. Aneja, Graham Hughes, Valerie Elliott Consumer Editor, Sadie Gray, Stephanie Condron, Charles Bremner, Dr Indarjit Singh Editor, Sara Lawrence, Ron Lewis, Tim Teeman, Derwent May, The Right Rev Trevor Willmott Sufragan Bisphop, Russell Kempson, Graham Spiers, Suzy Jagger, John Webster, Geoffrey Alderman, Oliver Kay, Mark Henderson Science Editor, Dr E. M. Yates President, Sir Oscar Proud, Sam Coates, John Hopkins Golf Correspondent, Rob Wright, Gabriel Rozenberg, Bernard Lagan, Tim Smit Cbe, Chief Executive, Neil Harman Tennis Correspondent, Martin Samuel, C. Stearn, Raymond Keene, The Rt Hon the Lord Archer of Sandwell, Matthew Pryor, Matt Hughes, Christine Buckley Industrial Editor, George Cox, Dr Tanya Byron, Andrew Drummond, Gareth Roberts, Chris Campling, Fran Yeoman, Adam Fresco Crime Correspondent, Michael Wood, Helen Nugent, John Carr, Lord Wedderburn, Kenneth Denby, Gabriel Rozenberg Economics Reporter, David Richards, Canon David Watson, Professor Lord May of Oxford Former President, Dalya Alberge, David Hands Rugby Correspondent, Owen Slot Chief Sports Reporter, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Paul Simons, Tony Cascarino, Adam Fresco, Tom Dart, William Rees-Mogg, Dominic Kennedy, Sam Coates Chief Political Correspondent, Steve Hawkes, Tim Hames, Jeremy Cross, Carin Rubenstein, Thomas Catan, Anjana Ahuja, George Caulkin, Caitlin Moran, Neil Fisher, Walter Gammie, Professor Sir John Lawton President, J. Cumming MacDona, Sameh El-Shahat, Philippe Saint-Andre, Martin Waller, Lisa Verrico, Patrick Foster, Mark Baldwin, Sarah Butler, Dr Richard J . Gornall High President, Benedict Nightingale, Dr Thomas Stuttaford, Judith Heywood Deputy Property Editor, Stephen Dalton, Leo Lewis, Bill Edgar, Tony Halpin, Valerie Grove, Rosemary Behan, Olav Bjortomt, Miles Costello, Nicola Copping, David Robertson, Richard Misek, Christopher Irvine,
... Scott in a spin after Leighton upset odds Quinn reaches out in effort to save the soul ...
2007 - Gale Group | TDA
José R. Cortés, Alberto Ambesi‐Impiombato, Lucile Couronné, S. Aidan Quinn, Christine S. Kim, Ana Carolina da Silva Almeida, Zachary J. West, Laura Belver, Marta Sanchez Martin, Laurianne Scourzic, Govind Bhagat, Olivier Bernard, Adolfo A. Ferrando, Teresa Palomero,
Angioimmunoblastic T cell lymphoma (AITL) is an aggressive tumor derived from malignant transformation of T follicular helper (Tfh) cells. AITL is characterized by loss-of-function mutations in Ten-Eleven Translocation 2 (TET2) epigenetic tumor suppressor and a highly recurrent mutation (p.Gly17Val) in the RHOA small GTPase. Yet, the specific role of RHOA G17V in AITL remains unknown. Expression of Rhoa G17V in CD4+ T cells induces Tfh cell specification; increased proliferation associated with inducible ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Cell Press | Cancer Cell
William Kingston, Tunku Varadarajan, Jon Ashworth, Gerald Stranraer-Mull, Andrew Pierce, Patricia Davies, Zahid Hussain, Andrew Pierce, Joanna Bale and James Landale, Michael Theodoulou and Michael Evans, Magnus Linklater, David Newland, Gordon Allan, Janet Bush, Economics Correspondent, Harvey Elliott, Mary Riddell, Christopher Hadley, Susan Bell, Hilary Finch, Andrei Navrozov, George Sivell, S. J. Casely, Peter Foster, Carl Mortished, Morag Preston, Simon Wilde, Stewart Tendler, Crime Correspondent, Eve-Ann Prentice, Diplomatic Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Robert Miller, Martin Fletcher, Pat Gibson, John Gribbin, John Bryant, Steve Keenan, Peter Jones, David Charter Education Correspondent, Peter Ball, Debra Craine, Raymond Keene Chess Correspondent, Jeanette Winterson, Jenny MacArthur, Robert Bruce, Glyn Maxwell, John Young, Anatole Kaletsky, Quentin Letts, Martin Symington, John O'leary, Peter Barnard, John O'leary Education Editor and David Charter, J. E. Abberton, Russell Kempson, Janet Bush and Alasdair Murray, Robert Runcie, Lin Jenkins, Barry Millington, John Hopkins Golf Correspondent, Stephen Wood, Rod Hill and John Everett, John Higgins, David Powell Athletics Correspondent, Andrew E. A. Selous, David Charter, Education Correspondent, Christine Buckley, Peter Davalle, Emma Wilkins, P. H. S, Robert Whymant and Abby Tan, Eric Reguly, Sarah Cunningham, Nigel Hawkes, Science Editor, Dominic Kennedy Social Affairs Correspondent, Oliver August, Andrew Pierce Political Correspondent, Robert Parker-Eaton, Stewart Tendler, Michael Hornsby, Agriculture Correspondent, Kate Alderson, Daniel J. Boorstin, Sara Starkey, William Rees-Mogg, David Churchill, David Charter's, George Smith, Eileen McCabe, Rob Hughes, Football Correspondent, Jude Hawes, Tim Hames, Des Dearlove, Kathryn Knight, Anthony Alment President, Aidan Day, Rodney Parkins, Richard Dykes, Ben MacIntyre, John O'leary and David Charter, S. T. Burgess, Bruce Martin, Frank Davis, Richard Beeston, Philip Webster, Fraser Nelson, A. M. Riley, Nigel Hawkes Science Editor, Neville Brown, Graham Wheeler, Kathleen Read, Benedict Nightingale, Tess Knighton, Tom Rhodes, Dr Thomas Stuttaford, Sam Kiley, John Parry, Alasdair Murray, Robert Whymant, Julia Ellis, Jonathan Mirsky, Christine Buckley, Industrial Correspondent,
... Picture Gallery Masterkova shatters mile record Curcic and Quinn move back into Premiership spotlight Racing 39 Direct ...
1996 - Gale Group | TDA
Francesco Abate, Ana C. da Silva-Almeida, Sakellarios Zairis, Javier Robles‐Valero, Lucile Couronné, Hossein Khiabanian, S. Aidan Quinn, Mi‐Yeon Kim, Maria Antonella Laginestra, Christine Kim, Danilo Fiore, Govind Bhagat, Miguel Á. Piris, Elı́as Campo, Izidore S. Lossos, Olivier Bernard, Giorgio Inghirami, Stefano Pileri, Xosé R. Bustelo, Raúl Rabadán, Adolfo A. Ferrando, Teresa Palomero,
Significance Guanine nucleotide exchange factor VAV1 encodes an adaptor and signal transduction factor with important roles in T-cell receptor signaling. This study identifies activating VAV1 recurrent mutations and VAV1 fusions in peripheral T-cell lymphomas, directly establishing an oncogenic role for constitutive VAV1 signaling in the pathogenesis of this disease.
Tópico(s): CAR-T cell therapy research
2017 - National Academy of Sciences | Proceedings of the National Academy of Sciences
George Cole, Alyn Shipton, Roger Everest, Anthony Harris, Tunku Varadarajan, Jon Ashworth, David Adams, Iain R. Webb, Chris Ward, Grace Bradberry, Roy Barley, Jeremy Laurance, Richard Ford, Home Correspondent, Simon Barnes, James A. Leek, Gordon Allan, Robert Breckman, Philip Howard, Hilary Finch, Jeremy Kingston, James Bone, Rachel Campbell-Johnston, Lynne Truss, Peter Foster, Carl Mortished, Morag Preston, Simon Wilde, Geoff Brown, Robert Sheehan, Bridge Correspondent, Robert Miller, Martin Fletcher, Keith Rodgers, Duncan Alexander, John O'leary Education Editor, Howard Davies, Patrick Minford, M. E. Pease, Aidan V. Lyons, Norman Hammond, Archaeology Correspondent, Peter Ball, Giles Whittell and our Foreign Staff, Raymond Keene Chess Correspondent, Stephen O'brien, Rachel Kelly, Ross Dunn, Rodney Milnes, Michael Clark, Charles Bremner, Saul Bellow, David Charter, Philip Bassett, Industrial Editor, Diana Davenport, Russell Kempson, Paul Durman, Anthony Kilvert, Brenda Maddox, Andy Lavender, Belinda Archer, J. P. Rudland, John Hopkins, David Miller, Lin Jenkins, Michael Prestage, Raymond Keene, Peter Davalle, N. L. Denton, Emma Wilkins, Michael J Hendrie Astronomy Correspondent, Peter J. Cook, Director, Paul Wilkinson, P. H. S, Joseph Dean, Peter Bryan, Chris Partridge, Caroline Merrell, Richard Owen, Mike Lyddiard, Roger Boyes, Sarah Cunningham, David Fanning, Oliver August, David Hands Rugby Correspondent, Julian Muscat, Justin Huggler, Dominic Kennedy, Giles Whittell, Eileen McCabe, Rob Hughes, Football Correspondent, Michael Kallenbach, James Pringle, Chris Parker, Jason Nissé, Mel Webb, Gerald Larner, Jill Sherman and Jeremy Laurance, Jennai Cox, Anjana Ahuja, Bill Frost Arthur Leathley and Michael Evans, Alan Lee, Ben MacIntyre, Ray Hatley, Richard Beeston, Brian Glanville, Fraser Nelson, Tim Jones, Kate Bassett, Eoin Fowell, Alan Coren, Selwyn Ward, Benedict Nightingale, Nigel Powell, Tom Rhodes, Dr Thomas Stuttaford, Marianne Curphey, Lindsay Nicolle, Richard Morrison, David Maddock, Colin Farrington, Alasdair Murray, Keith Rossiter, Anthony Howard, Richard A. Pike, Colin McQuillan, Christopher Irvine, Dominic Kennedy, Social Services Correspondent,
... sales dip CRT cedes control TV Corporation ahead Quinn lands top post at Nomura Business Roundup Tourist ...
1996 - Gale Group | TDA
Samuel J. Vidal, Verónica Rodríguez-Bravo, S. Aidan Quinn, Ruth Rodríguez‐Barrueco, Amaia Lujambio, Estrelania Williams, Xiaochen Sun, Janis de la Iglesia-Vicente, Albert Lee, Ben Readhead, Xintong Chen, Matthew D. Galsky, Berta Esteve, Daniel P. Petrylak, Joel T. Dudley, Raúl Rabadán, José M. Silva, Yujin Hoshida, Scott W. Lowe, Carlos Cordon‐Cardo, Josep Domingo‐Domenech,
Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate therapeutic strategies that improve clinical outcomes. We used experimental models and clinical databases to identify GATA2 as a regulator of chemotherapy resistance and tumorigenicity in this context. Mechanistically, direct upregulation of the growth hormone IGF2 emerged as a mediator of the aggressive properties regulated by GATA2. IGF2 in turn activated IGF1R and INSR as well as a downstream polykinase program. ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2015 - Cell Press | Cancer Cell
Meghna Shetty, Susan D'arcy, John Dugdale, Der Rosenkavalier, M Downes, Reginald Knapp, A Dales, Colin Thrasher, Matthew Wall, David Burghes, Patrick French, Barbara Hall, Nigel Botherway, Christopher Morgan Religious Affairs Correspondent, Kurt Schwitters, Andrew Warshaw, Simon Singh, David Mills, W L, Greg Williams, Dan Pearson, John Peter, Emma Moore, Amanda Ursell, Ian Gilroy, John Jay, A S, Susan d'Arcy, David Bailey, Frank Whitford, Natasha Woods, Ivo Tennant, Ferdinand Mount, Paul Bunyan, Whistle Blower, Nail Varnishes, Sally Payne, David Smith, John Harlow Social Affairs Editor, Kirstie Hamilton City Editor, Matthew Wall's, Chris Dignan, Melanie Phillips, Nick Pitt, Lucy Irvine, Neil Wormald, Katherine Mansfield, Nick Sullivan, Clive Davis, Stephen Grey, Dylan Jones, Adam Lively, Bruce Kemble, Dr Roger Henderson, Stephanie Debere, Simon Read, Liam Stebbing, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Robina Dam, Eleanor Mills, Anthony Sattin, Anthony J Roberts, Robert Winnett, Barbara Trapido, Irwin Stelzer, Robert Hewison, Peter Wilson, Roger Anderson, Mark Ottaway, David Dougill, Slavko Curuvija, David Summer Smith, John Evans, Philip Kingsley, Elliott Smith, Thrasy Petropoulos, Sarah Toyne, David Hewson, Tania Alexander, Harvey Porlock, Cally Law, Margaret Coles, Hugh Canning, Margarette Driscoll, Alasdair Reid, Peter Watson, Jeremy Clarkson, Nigel Williams, Stewart Lee, Louise Taylor, Brain Glanville, John Waples Deputy City Editor, Patricia Nicol, Kevin Davies, Waldemar JANUSZCZAK's, John Embrey, C Drake, James Alexander, Peter Hughes, Paul Merton, Alan Millard, Grace Clappara, Sam Murphy, Andrew Barr, Phil Craigie, Cathy Scott-Clark, Tony Wheeler, Graham Otway, William Frating, Mrs P J H, Nick Gardner, Shelley von Strunckel, Dermot Reeve, Phillip Oppenheim, Lorna Macleod, Stuart Wavell, Josephine Smit, Paul Donovan, Aidan Haile, Amanda Redman, Caroline Aherne, Sue Lawrence, Tim Salmon, Simon Mills, Hugh McIlvanney, Michael Rallings, Smita Talati, Paul Driver, Derek Clements, Nicholas Hellen, Maeve Sheehan, Peter Windsor, Nick Raynsford, Ian Hawkey, Camille Paglia, Richard Brooks, Christopher Morgan, Samantha Todhunter, Katie Hickman, Alicia Wyllie, Kevin Taylor, Peter Bates, Tim Kelsey, Steve Farrar Science Correspondent, Kirstie Hamilton, Tom Shone, Mark Edwards, Susan Clark, Stephen Amidon, Matthew Kalman, Charlie Dimmock, Jennifer Asiama, Haldee Findlay-Levin, Raymond Keene, Amanda Foreman, Cosmo Landesman, Marie Colvin, Diana Wright, Jim Smith, Helen Hawkins, Stephen Jones, John Foley, Nick Cain, Stephen Bevan, Andrew Smith, Paul Nuki, Tim Allen, Neal Casal, Arthur Samouelle, Rob Ryan, John Trotter, Claire Oldfield, David Walsh, Jack Grimston, Bryan Appleyard, Lois Rogers Medical Correspondent, Richard Seba, Paul Kavanagh, Josh Salzmann, R W Johnson, Steve Richard, Danny Roth, Garth Alexander, Peg Hailey, Richard Earle, Dr A Wilkes (Headmaster), Maurice Chittenden, President Bill Clinton, Richard Brooks Arts Editor, Kristie Hamilton, Ray Hutton, Jonathan Powell, Murray, Stephen Downes, Andrew Rogers, Tara Palmer-Tomkinson, K Harle, Frank McLynn, V Harvey, Michael Sheridan, Sean Hargrave, Anthony Green, Niall Ferguson, Fay Weldon, Matthew Lynn, Godfrey Smith, Michael Austin, Michael Hodges, S C Pegram, John Waples, Harold Fielding, Jeremy Hart, A A Gill, Denis Walsh, Matthew Campbell, Brian Glanville, Martin Wroe, Jackson Pollock, Tom Hagler, David Hutcheon, Tom Robbins, Stephen Pettitt, Paul Hooper, Kevin Goldstein-Jackson, Jeremy Langmead, Sally Kinnes, Adrian Levy, David Wickers, Roger Dobson, Tom Rhodes, Nick Gardner Deputy Money Editor, John Cornwell, Jen Petrie, Mark Hodson, Nicholas Hellen Media Correspondent, Joe Lovejoy, Donald Dewar, Rupert Steiner, Morris Gleitzman, Chris Lightbown, Michael de Larrabeiti, Dan Cairns, David Parsley, Nick Foulkes, R Thwaite, General Sir Michael Rose, Simon Wardell, India Knight, Jim Murphy, Simon Howard, Barry Newcombe, Mathew Horringer, Dominic Rushe, Boris Schapiro, Cathy Woodhead,
... Premiership Late Strikes Corica points way for Wolves Quinn prepares to settle old scores Sunderland's striker ...
1999 - Gale Group | Sunday Times HA GDA
Kevin Y. Ennis, Ming‐Hui Chen, Glenna C. Smith, Anthony V. D’Amico, Yuanye Zhang, S. Aidan Quinn, Shannon N. Ryemon, Daniel E. Goltz, Louis B. Harrison, Ronald D. Ennis,
Purpose:The impact of economic recessions on the incidence and treatment of cancer is unknown.We test the hypothesis that cancer incidence and treatment rates decrease during a recession, and that this relationship is more pronounced in cancers that present with mild, more easily ignored symptoms.Methods and Materials: Data on incidence and treatment for all cancers, and breast and pancreatic cancers specifically, from 1973-2008, were collected using Surveillance Epidemiology and End Results (SEER). ...
Tópico(s): Health disparities and outcomes
2015 - Ivyspring International Publisher | Journal of Cancer
Phil Yates, Arthur Leathley, Transport Correspondent, Kenny MacIver, Robert Cole, Chris Ward, Alexandra Frean, David Lort-Phillips, Sarah Potter, Simon Barnes, Richard Ford, Home Correspondent, David Fickling, Claire McDonald, Ivo Tennant, Robert Lea, Raymond Snoddy, Media Editor, Philip Howard, Susan Bell, Jeremy Kingston, Joanna Bale, James Bone, Caroline Merrell and Adam Jones, Carl Mortished, James Olsen, Morag Preston, Enid Shelmerdine, Christine Buckley Industrial Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Joe Joseph, Jenny Lind, R. L. Turner, Paul Wilkinson, North East Correspondent, Pat Gibson, Paul Fitzpatrick, Warren Chrismas, Valerie Elliott, Jason Allardyce, Dominic Walsh, Debra Craine, Raymond Keene Chess Correspondent, Nicholas Booth, Julia Neuberger, Dalya Alberge Arts Correspondent, Aidan Ruff, Alan Hamilton, Stephen Farrell, Ian Murray, Medical Correspondent, Rodney Milnes, Michael Clark, Eve-Ann Prentice, T. P., Chole Barker, Alix Ramsay, Tennis Correspondent, Charles Bremner, David Stevenson, Rachel Campbell Johnston, Peter Barnard, Tam Dalyell, Ian G. S. Robertson, Ralph Hardy, Jasper Gerard, Christopher Joll, Paula Hawkins, Russell Kempson, Paul Armstrong, Peter Miles, Richard Cork, Paul Durman, Carol Midgley Media Correspondent, Rachel Kelly Property Correspondent, Marit Hargie, Rob Wright, Christopher Martin-Jenkins, Chief Cricket Correspondent, Geoffrey Dean, Stephen Wood, Stuart Miles, Arthur Leathley Aviation Correspondent, Raymond Keene, Matt Dickinson, Frances Gibb, Legal Correspondent, Paul Wilkinson, Carl Mortished, International Business Editor, David Powell, Athletics Correspondent, Damian Whitworth, Sarah Cunningham, Ian Murray Medical Correspondent, Philip Webster, Political Editor, David Hands Rugby Correspondent, Neil Jones, John Allison, Anne Ashworth, Tim Wapshott and Simon Munk, Simon Munk, Giles Whittell, Alan Copps, Claude R. Hart, Jason Nissé, Craig Lord, Matthew Parris, Chris McGrath, George Caulkin, Russell Jenkins, Magnus Linklater and Jason Allardyce, John Jenkin, Julian Bray, Peter Riddell, Ben MacIntyre, Ray Hatley, Graham Stow, Chief Executive, Alasdair Murray Economics Correspondent, David Sinclair, Simon Jenkins, Fraser Nelson, Roy Murphy, Mark Henderson, Martin Waller, Chris Ayres, Nigel Hawkes Science Editor, Alan Coren, Benedict Nightingale, Nigel Powell, John Peter Hudson, Dr Thomas Stuttaford, Lindsay Nicolle, Richard Morrison, Bill Edgar, Chloe Barker, Michael Binyon, Diplomatic Editor, and Sean Hillen, Edward Vale, Nicholas Young, Chief Executive, James Christopher, Adam Sherwin, Michael Evans, Alasdair Murray, Ray Whitney, Richard Ford, Christopher Irvine, Joanna Coles, Arthur Leathley Transport Correspondent,
... French Property Exhibition Multiple Display Advertising Items Portugal Quinn punished for rash manoeuvre Racing Stewards Disqualify Chester ...
1999 - Gale Group | TDA
Josep Domingo‐Domenech, Samuel J. Vidal, Verónica Rodríguez-Bravo, Mireia Castillo-Martín, S. Aidan Quinn, Ruth Rodríguez‐Barrueco, Dennis M. Bonal, Elizabeth Charytonowicz, Nataliya Gladoun, Janis de la Iglesia-Vicente, Daniel P. Petrylak, Mitchell C. Benson, José M. Silva, Carlos Cordon‐Cardo,
Acquired resistance to Docetaxel precedes fatality in hormone-refractory prostate cancer (HRPC). However, strategies that target Docetaxel resistant cells remain elusive. Using in vitro and in vivo models, we identified a subpopulation of cells that survive Docetaxel exposure. This subpopulation lacks differentiation markers and HLA class I (HLAI) antigens, while overexpressing the Notch and Hedgehog signaling pathways. These cells were found in prostate cancer tissues and were related to tumor aggressiveness ...
Tópico(s): Cancer Cells and Metastasis
2012 - Cell Press | Cancer Cell
Giles Smith, Andrew Robson, Gabriele Marcotti, Jon White, Phil Yates, Jim Lyon, Rosemary Righter, Jon Ashworth, Catherine Philip, Matthew Syed, Kate Hammond, Alexandra Frean, Gary Duncan, Peter Lansley, Robert Thicknesse, Paul Hoggart, David Rhys Jones, Jim Quinn, Andrew Robinson, David Blunkett, Archie Thomson, , Alex Fynn and Kevin Whitcher, Philip Howard, Carol Midgley, Tara Holmes, David Chater, James Ducker, John Habgood, Nic Hopkins, Alison Kervin, Rob Sixsmith, Alexandra Frean Social Affairs Correspondent, Kevin Eason, Martin E. Simons, Gerald Davies, Sam Lister, Giles Coren, David Sharrock, Antonia Senior, Valerie Elliott Countryside Editor, David McVay, Joyce Glasser, London Nw3, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Steve Bird, Debra Craine, Gary Jacob, Patrick Marmion, Tim Reid, Rosemary Bennett, Angela Jameson Industrial Correspondent, Mark Serwotka, General Secretary, Roger Blears, Phoebe Greenwood, Tom Foulkes, Director General, Robin Young, Stephen Farrell, Anselm Kuhn, Phil Gordon, David Hands, Charles Bremner, Ron Lewis, Stefanie Marsh, David Charter, Nicholas Wapshott, Pat Hodgson, Barry Daniels, Hugo Rifkind, Alison Davis, Blandford forum, Alan Davies, Russell Kempson, Alistair J. Sinclair, Christine Selb, Ronan McGreevy, Peter Bainbridge, Lisa Armstrong, Rick Broadbent, Tom Baldwin, Stephen Burgen, Paul Speakman, John Hopkins, Jon Ashworth and Stefanie Marsh, Ann Treneman, Michael R. Cavaghan-Pack, John Hopkins Golf Correspondent, Aki Rihlahti, Michael Brookers, Raymond Keene, Christine Buckley, Sean MacAulay, Matt Dickinson, Brain Shelley, Simon Hart, Rosemary Bennett Deputy Political Editor, Greg Hurst Parliamentary Correspondent, Lawrence Breen, Peta Bee, Abigall Rayner, John A. S. Flynn, Chris Campling, Cathy Harris, Richard Owen, Tim Spanton, Mick Hume, poll detalls, Marc Padgett, Jane Feinmann, Stewart Tendler, David Hands Rugby Correspondent, Aidan Sherry, Tony Cascarino, Tom Dart, Paul Simons, Anna Frame, Michelle Henery, William Rees-Mogg, John Goodbody, Nick Szczepanik, Mary Ann Sieghart, Anthony Senior, Philip Webster Political Editor, David Pinless, Tim Hames, Jeremy Cross, Chris McGrath, George Caulkin, Burham Wazir, Walter Gammie, Peter Riddell, Mrs Dippy, Ben Webster, Tom Hennigan, Richard Miles, Lea Paterson, Lewis Stuart, John Locke, Bristol, Michael Horsnell, Lisa Verrico, Guy Herbert, Christopher Irvine, Carl Mortished International Business Editor, Mark Baldwin, Nigel Hawkes Health Editor, Jill Duplex, Glenn Renshaw, Dennis Rutherford, John Chambers, Ian Parkin, Dr Thomas Stuttaford, Stephen Dalton, Richard Morrison, Paul Connolly, Alyson Rudd, Bill Edgar, Adam Sherwin, Mark Venables, Matthew Connolly, Randy Cohen, Alan Lee Racing Correspondent, Richard Laming, Philip Pank,
Blair still in trouble Iraq vote reprieve New Labour in a spin Win a Superb Trip to the Rugby World Cup -… Beckham: my sore foot and those late nights The ...
2003 - Gale Group | TDA
Máirín E. McMenamin, Aidan Quinn, Hugh Barry, Duncan Sleeman, Graham Wilson, Mary Toner,
Tópico(s): Vascular Tumors and Angiosarcomas
1997 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Clive Coleman, Andrew Robson, Matt Dickinson Chief Sports Correspondent, Simon Barnes Chief Sports Writer, Gabriele Marcotti, Jeremy Goldsmith, Major-General the Rev Morgan Llewellyn, Meirion Jones Senior Producer, Andrew Billen, Jo Glanville Editor, David Hencke, Lawrence Schiller, Frances Gibb Legal Editor, Simon Barnes, Peter Lansley, Ashling O'Connor Olympics Correspondent, Mark Souster, Catherine Boyle, David Rose, Richard Thomas, Jonathan Freedland, Ivo Tennant, Alexandra Frean Education Editor, Michael Evans Defence Editor, Jenni Rutherford, Philip Howard, Lieutenant-General Sir Jack Deverell, Carol Midgley, Hilary Finch, Geoffrey Holroyde, David Chater, Martin McElroy, Moritz Volz, Clive Davis, Carol Sarler, Gabrielle Starkey, Charlene Sweeney, Sam Marlowe, Martin Samuel Chief Football Correspondent, Joe Joseph, Anthony Seldon, Andrew Norfolk, Valerie Elliott Countryside Editor, John Clarke, William Horsley Chairman, Jane MacArtney, Frieda Hughes, Donald Hutera, Francis Elliott, Deborah Haynes, Jack Malvern, Ruth Gledhill, Gary Jacob, Norman Harris, Rosemary Bennett, Dan Sabbagh, Jeremy Dear General Secretary, Anatole Kaletsky, John McIntosh, Chris Johnston, Ron Lewis, General Sir Hugh Beach, Adam Sherwin Media Correspondent, Mark Ogden, General Sir Rupert Smith, Derwent May, David Goodhart Editor, Richard Hobson Deputy Cricket Correspondent, Graham Spiers, Suzy Jagger, Gary Duncan Economics Editor, Oliver Kay, Catherine O'brien, Mark Henderson Science Editor, Dr David G. Green Director, Lieutenant-General Sir Roderick Cordy-Simpson, Patrick Hosking Banking and Finance Editor, Rick Broadbent, Tom Baldwin, John Westerby, Ben Quinn, James Rossiter, Scott Rutherford, Jonathan Dimbleby Chairman, Rob Wright, Geoffrey Dean, Alice Olins, Edward Gorman Motor Racing Correspondent, Neil Harman Tennis Correspondent, Martin Samuel, Scott Varland, Raymond Keene, Adam Sage, Sean O'Neill Crime and Security Editor, Paul Kane, Matt Hughes, Major-General Patrick Cordingley, Christine Buckley Industrial Editor, Dr Tanya Byron, Kaveh Solhekol, Marcus Binney Architecture Correspondent, General Lord Ramsbotham, Chris Campling, Imogen Holroyde, Francis Elliott Deputy Political Editor, Kenneth Denby, Peter Dixon, Dominic Ponsford Editor, Shami Chakrabarti, Dalya Alberge, Owen Slot Chief Sports Reporter, David Hands Rugby Correspondent, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Paul Simons, Tony Cascarino, Tom Dart, Nigel Kendall, William Rees-Mogg, Nick Szczepanik, Martin Bright, Michel Platini, Peter Wilby, Tim Hames, Dominic Maxwell, Christopher Hawtree, Sophie Yu, Sonia Verma, Tony Hannan, Caitlin Moran, Roy Greenslade, Nuj Richard Watson, Vivien Coombs, Christopher lrvine, Andrew Giligan, Aidan White General Secretary, Mark Henderson, Martin Waller, Lewis Smith Environment Reporter, Patrick Foster, Jonathan Heawood Director, Nigel Hawkes Health Editor, Carl Mortished World Business Editor, Mark Baldwin, Benedict Nightingale, Rick Broadbent Athletics Correspondent, Judith Heywood Deputy Property Editor, Stephen Dalton, Bill Edgar, James Christopher, Michael Evans, Mark Venables, Owen Slot, Olav Bjortomt, Mike Atherton Chief Cricket Correspondent, General Sir Michael Rose, David Robertson, Field Marshal Lord Bramall, Lisa Verrico,
Index Who said that hot air never impresses the judges? Parents to get power to call in school inspectors More frequent checks on complacent teachers ...
2008 - Gale Group | TDA
Aidan Quinn, Courtney Taylor, Tarun Sabharwal, T Sikdar,
The outcome of teaching the core of knowledge to clinicians and the impact of the POPUMET regulations was assessed using an anonymous questionnaire. 82 of 120 (76%) of non-radiologists responded, of these 37% had attended a radiation protection course. Course attendance improved knowledge of the existence of the POPUMET regulations (p < 0.0001) and the ALARA principle. Course attendance made no difference to knowledge of the relative radiation dose of various radiological procedures. An underestimation ...
Tópico(s): Advances in Oncology and Radiotherapy
1997 - Wiley | British Journal of Radiology