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Artigo Acesso aberto Revisado por pares

Funda Meric‐Bernstam, Navita Somaiah, Sydney Dubois, Ecaterina E. Dumbrava, Geoffrey I. Shapiro, Minal Patel, Shom Goel, TT Bauer, Dawn Pinchasik, Allen Annis, Manuel Aivado, Vojin Vuković, Mohammed Saleh,

... identification NCT02909972. Legal entity responsible for the study Aileron Therapeutics, Inc. Funding Aileron Therapeutics, Inc. Disclosure F. Meric-Bernstam: Honoraria (self): ... Debio; Bayer; PUMA; CytoMx; Research grant / Funding (institution): Aileron; Zymeworks; Curis; Pfizer; eFFECTOR; Abbvie; Guardant Health; Daiichi ... palbociclib. M.R. Patel: Research grant / Funding (institution): Aileron Therapeutics, Inc. T. Bauer: Advisory / Consultancy: Ignyta; Guardant ... Research grant / Funding (institution): Principa; Peleton, Immunocore; Roche; Aileron; BMS; Amgen; Moderna; Research grant / Funding (institution): Sanofi; ...

Tópico(s): Protein Degradation and Inhibitors

2019 - Elsevier BV | Annals of Oncology

Artigo Revisado por pares

Andrei R. Shustov, Steven M. Horwitz, Jasmine Zain, Manish R. Patel, Sanjay Goel, Lubomir Sokol, Funda Meric‐Bernstam, Geoffrey I. Shapiro, Sunita D. Nasta, Murali Janakiram, David M. Weinstock, Ronald L. Korn, Marie Payton, D. Allen Annis, Dawn Pinchasik, Manuel Aivado, Amitkumar Mehta,

... Funding; ADC Therapeutics: Consultancy, Research Funding; Portola: Consultancy; Aileron Therapeutics: Consultancy, Research Funding; Innate Pharma: Consultancy; Trillium: ... Research Funding; Debiopharm: Research Funding; Bayer: Research Funding; Aileron Therapeutics: Research Funding; PUMA Biotechnology: Research Funding; CytomX ... Nasta:Roche: Research Funding; Takeda/Millenium: Research Funding; Aileron: Research Funding; Rafael/WF: Research Funding; Merck: Other: ... or advisory committees. Weinstock:Novartis, Astra Zeneca, Abbvie, Aileron, Surface Oncology, Daiichi Sankyo: Research Funding; Novartis: Consultancy, ...

Tópico(s): CAR-T cell therapy research

2018 - Elsevier BV | Blood

Artigo Acesso aberto Revisado por pares

Anmin Zhao, Dongyu He, Dongsheng Wen,

... such UAVs, a novel design scheme of split aileron is proposed that is similar to the concept of split flap. The function of the separated aileron is implemented utilizing an electro-servo system actuated ... design of the bottom position of the split aileron structure, its aerodynamic characteristics, maneuverability and structural weight are evaluated by comparing with a traditional hinged aileron. The results indicate that the proposed design of the detached aileron can enhance the average aerodynamic efficiency of the ...

Tópico(s): Advanced Aircraft Design and Technologies

2019 - Elsevier BV | Aerospace Science and Technology

Artigo

Richard J. Prazenica, Daewon Kim, Hever Moncayo, Boutros Azizi, May Chan,

... discussed in this paper, macro-fiber composite (MFC) aileron actuators are designed for implementation on a medium- ... and high bandwidth. In this study, several MFC aileron actuator designs were evaluated through a combination of ... The current design consists of glass fiber composite ailerons with two unimorph MFC actuators embedded in each aileron to produce upward deflection. Wind tunnel test results ... and drag coefficients for different levels of MFC aileron actuation. Preparations for open-loop flight testing using ...

Tópico(s): Aeroelasticity and Vibration Control

2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Artigo Acesso aberto

Miranda T. Riosbaas, Kenneth J. Loh, Greg O’Bryan, Bryan R. Loyola,

... for the design and optimization of a morphing aileron using flexible matrix composite (FMC) actuators is developed. ... were based on the use of a morphing aileron with an existing medium size commercial transport aircraft limiting the planform to the existing conventional aileron. The design uses two sets of contracting FMC actuators operating independently to actuate the deformable aileron in both trailing edge up and down cases ... matching coefficient of lift values of a conventional aileron. The design was optimized by developing a series ...

Tópico(s): Topology Optimization in Engineering

2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Artigo

Gianluca Amendola, Ignazio Dimino, Antonio Concilio, Marco Magnifico, Rosario Pecora,

... feasibility of an innovative full-scale camber morphing aileron device. In the framework of the "Adaptive Aileron" project, an international cooperation between Italy and Canada, ... growing interest in extending morphing functionalities to the aileron region preserving its main functionality in controlling aircraft ... this paper, the preliminary design of the adaptive aileron is first presented, assessed on the base of ... three consecutive parts, connected with spanwise stringers. The aileron shape modification is then implemented by means of ...

Tópico(s): Composite Structure Analysis and Optimization

2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Artigo Revisado por pares

J. Soovere,

... to verify the design of the composite inboard aileron for the L-1011 airplane is described. The composite aileron is fabricated from graphite/epoxy minisandwich covers which ... studies on a representative section of the composite aileron, culminating in the accelerated sonic fatigue proof test. The composite aileron sustained nonlinear panel vibration during the proof test ...

Tópico(s): Engineering Applied Research

1982 - American Institute of Aeronautics and Astronautics | Journal of Aircraft

Artigo Revisado por pares

Ilinca Năstase, Amina Meslem, Vlad Iordache, Iolanda Colda,

... from innovative rectangular air diffusion grilles with lobed ailerons ensure higher mixing in a room than baseline ... from classical rectangular air diffusion grilles with straight ailerons. The experimental approach uses time resolved and classical ... the jet issued from the grille with lobed ailerons is found to be greater than in the case of the standard grille with straight ailerons. This way, lobed ailerons might be a solution for the optimization of ...

Tópico(s): Infection Control and Ventilation

2010 - Elsevier BV | Building and Environment

Artigo

Gianluca Amendola, Ignazio Dimino, Francesco Amoroso, Rosario Pecora,

... innovative technologies devoted to morphing structures. The "Adaptive Aileron" project represents a joint cooperation between Canadian and ... design, manufacturing and testing of a variable camber aileron for a regional aircraft is presented. The key enabling technology for the presented morphing aileron is the actuation structural system, integrating a suitable ... electrical power to supply non-propulsive systems. The aileron design features are validated by targeted experimental tests, ...

Tópico(s): Biomimetic flight and propulsion mechanisms

2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Artigo Acesso aberto Revisado por pares

David A. Sallman, Uma Borate, Elizabeth H. Cull, William B. Donnellan, Rami S. Komrokji, Ulrich Steidl, Maria Margarita Corvez, Marie Payton, D. Allen Annis, Dawn Pinchasik, Manuel Aivado, Amit Verma,

... Honoraria, Speakers Bureau; Novartis: Honoraria, Speakers Bureau. Steidl:Aileron: Consultancy, Research Funding. Corvez:Aileron Therapeutics Inc.: Employment, Equity Ownership. Payton:Aileron Therapeutics: Employment, Equity Ownership. Annis:Aileron Therapeutics Inc.: Employment, Equity Ownership, Patents & Royalties. Pinchasik:Aileron Therapeutics Inc.: Employment, Equity Ownership. Aivado:Aileron Therapeutics Inc.: Employment, Equity Ownership, Patents & Royalties.

Tópico(s): Click Chemistry and Applications

2018 - Elsevier BV | Blood

Artigo Revisado por pares

Maurizio Arena, Francesco Amoroso, Rosario Pecora, Gianluca Amendola, Ignazio Dimino, Antonio Concilio,

... design and the manufacturing of a variable camber aileron tailored to CS-25 category aircraft applications. This ... wind tunnel tests outcomes have been discussed. The ailerons typically constitute crucial elements for the aerodynamic forces ... been modelled within the numerical model of the aileron: the comparison between the modal characteristics of numerical ... better comprehend the dynamic response of a morphing aileron, primary knowledge for flutter and failure analyses.

Tópico(s): Aerodynamics and Fluid Dynamics Research

2018 - IOP Publishing | Smart Materials and Structures

Artigo Revisado por pares

Ruijie Sun, Zhou Zhou, Xiaoping Zhu,

This paper evaluates the flight quality of an aileron-free full-wing configuration UAV and proposes a ... to the disturbance, nonlinearity, and uncertainty) of the aileron-free full-wing configuration UAV. First, the flight ... quickly. To further solve the problem that the aileron-free full-wing configuration UAV is susceptible to ... proved. According to the flight quality evaluation, the aileron-free full-wing configuration UAV has poor flight ...

Tópico(s): Adaptive Dynamic Programming Control

2021 - Elsevier BV | Aerospace Science and Technology

Artigo Revisado por pares

Fulvio Romano, J. J. Fiori, Umberto Mercurio,

The current full depth aluminium aileron installed on the P180 AVANTI aircraft has been selected, as reference baseline, for the design of a new CFRP aileron developed within the VITAS project (Vector for Innovative ... detailed design approach, has led to an optimized aileron concept characterised by a strong reduction of the ... test performed for the certification of the aluminium aileron.

Tópico(s): Mechanical Behavior of Composites

2008 - Elsevier BV | Composite Structures

Artigo Acesso aberto Revisado por pares

Xin Zhao, Zhou Zhou, Xiaoping Zhu, An Guo,

... increase the proportion of solar cells covered, the ailerons were removed and a rudder was used to ... and yaw. Then, the dynamics model of an aileron-free layout UAV was developed, and the differences in maneuverability and stability of aileron-free UAV in plateau and plain areas were ... trajectory tracking control law were designed for the aileron-free UAV. Finally, the flight test was conducted ... and the success of the control system for aileron-free UAV, and analyzed the feasibility of perpetual ...

Tópico(s): Advanced Aircraft Design and Technologies

2020 - Multidisciplinary Digital Publishing Institute | Applied Sciences

Artigo Acesso aberto Revisado por pares

Wei-Li Qin, Wenjin Zhang, Chen Lü,

Aileron actuators are pivotal components for aircraft flight control system. Thus, the fault diagnosis of aileron actuators is vital in the enhancement of the ... and fault tolerant capability. This paper presents an aileron actuator fault diagnosis approach combining principal component analysis ( ... detection and location. First, several common faults of aileron actuators, which include force motor coil break, sensor ...

Tópico(s): Hydraulic and Pneumatic Systems

2016 - Hindawi Publishing Corporation | Shock and Vibration

Artigo Revisado por pares

Maurizio Arena, Rita Palumbo, Rosario Pecora, Francesco Amoroso, Gianluca Amendola, Ignazio Dimino,

... requirements on emissions and safety: an innovative morphing aileron implemented to increase both structural stability and the ... 25 airworthiness requirements and referring—initially—to nominal aileron functioning. Furthermore, a sensitivity investigation was carried out to assess the dynamic stability of the adaptive aileron, verifying the flutter clearance in the presence of ... of the actuation system. Safety values for the aileron control harmonic were investigated looking at potential certification ...

Tópico(s): Structural Engineering and Vibration Analysis

2018 - American Society of Civil Engineers | Journal of Aerospace Engineering

Artigo Revisado por pares

Tomi K. Sawyer,

... Drug DesignVolume 73, Issue 1 p. 3-6 AILERON Therapeutics Tomi K. Sawyer, Tomi K. Sawyer Chief ... Senior Vice-President, Drug Discovery and Innovative Technologies, AILERON Therapeutics, Cambridge, MA, USASearch for more papers by ... Senior Vice-President, Drug Discovery and Innovative Technologies, AILERON Therapeutics, Cambridge, MA, USASearch for more papers by ...

Tópico(s): Glycosylation and Glycoproteins Research

2008 - Wiley | Chemical Biology & Drug Design

Artigo Acesso aberto Revisado por pares

Hang Yuan, Chen Lü, Jian Ma, Zi-han Chen,

Fault detection for aileron actuators mainly involves the enhancement of reliability and fault tolerant capability. A fault detection method for aileron actuator under variable conditions is proposed in this ... as an observer, is established to monitor the aileron actuator and estimate the system output. The second ...

Tópico(s): Hydraulic and Pneumatic Systems

2015 - Elsevier BV | Applied Mathematical Modelling

Artigo Revisado por pares

N. S. Khot, F. Eastep, Raymond M. Kolonay,

A technique for augmenting the aileron to increase the roll rates of a high-performance aircraft at high dynamic pressures for enhancement of the rolling maneuver is ... to counteract the detrimental twisting moment of the aileron rotation to achieve recovery of the lost roll ... twist and camber resulting from use of the aileron only is described. The retwisting and recambering of ... the antisymmetric twist and camber deformation on the aileron-twisted wing to recover the lost roll performance.

Tópico(s): Computational Fluid Dynamics and Aerodynamics

1997 - American Institute of Aeronautics and Astronautics | Journal of Aircraft

Artigo Acesso aberto Revisado por pares

Ruxandra Mihaela Botez, Andreea Koreanschi, Oliviu Şugar Gabor, Yvan Tondji, M. Guezguez, J.T. Kammegne, Teodor Lucian Grigorie, Dragos George Sandu, Y. Mébarki, Mahmoud Mamou, Francesco Amoroso, Rosario Pecora, Leonardo Lecce, Gianluca Amendola, Ignazio Dimino, Antonio Concilio,

... morphing upper surface and interchangeable conventional and morphing ailerons was designed, manufactured, bench and wind-tunnel tested. ... was to demonstrate the wing upper surface and aileron morphing capabilities in improving the wing-tip aerodynamic ... up to 9% was obtained when the morphing aileron was introduced.

Tópico(s): Aerodynamics and Fluid Dynamics Research

2018 - Cambridge University Press | The Aeronautical Journal

Artigo Acesso aberto Revisado por pares

Dominique Farcy, A. Khrabrov, Maria E. Sidoryuk,

... attack and sideslip, degδ=(δe,δa,δr);elevator, aileron, and rudder deflections, degθpitch angle, degϕbank angle, degΩaircraft ... α and β; deflections of the elevator δe, aileron δa, and rudder δr; and the full nondimensional ... continuation on one of the parameters: elevator deflection, ailerons, or rudder deflection.Approximate calculation of spin parameters ... Fig. 19, where continuation of spin solutions on aileron deflection is performed. The dependence of the parameters ... the nominal and perturbed aerodynamic models. Using the aileron and rudder against rotation sometimes allows us to ...

Tópico(s): Statistical and numerical algorithms

2020 - American Institute of Aeronautics and Astronautics | Journal of Aircraft

Artigo Revisado por pares

Ahmed M. Hassan, Haithem E. Taha,

... due to a nonlinear interaction between elevator and aileron control inputs. In this effort, we perform a ... mechanism in comparison to the conventional mechanism (using ailerons only). Third, to simulate the airplane response to ... a Lie bracket interaction between the elevator and aileron control inputs. We modify existing nonholonomic motion planning ... to the conventional one during stall, where the aileron sensitivity degrades. In particular, the novel roll mechanism ...

Tópico(s): Robotic Path Planning Algorithms

2020 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Aerospace and Electronic Systems

Artigo Revisado por pares

Junming Zhang, Yubin Liu, Liang Gao, Benshan Liu, Yanhe Zhu, Xizhe Zang, Jie Zhao, Hegao Cai,

... certain limitations. For example, for roll control, the aileron rudder effect will be significantly reduced when flying ... unexplored. Therefore, the combination of wing deformation and ailerons is proposed to improve the roll control ability ... which demonstrates the advantages of the combination of ailerons and wing morphing in roll control and verifies ...

Tópico(s): Aerospace Engineering and Energy Systems

2022 - Institute of Electrical and Electronics Engineers | IEEE Robotics and Automation Letters

Artigo Acesso aberto

A. Airoldi, Giuseppe Quaranta, Alvise Beltramin, Giuseppe Sala,

... of numerical models referred to a morphing actuated aileron. The structural solution adopted consists of an internal ... the development of aeroelastic condensed models of the aileron, which are used in sensitivity studies and optimization ... makes also possible a comparison with a rigid aileron. The results show that the morphing system can ...

Tópico(s): Composite Structure Analysis and Optimization

2014 - | Advances in aircraft and spacecraft science

Artigo Revisado por pares

Gianluca Amendola, Ignazio Dimino, Antonio Concilio, Rosario Pecora, Francesco Amoroso,

... novel actuation system of a full scale morphing aileron for a regional aircraft wing. The proposed aileron architecture is characterized by segmented adaptive ribs. Each ... quick-return mechanism. In order to achieve the aileron target shapes, the system is driven by a ...

Tópico(s): Dynamics and Control of Mechanical Systems

2015 - Trans Tech Publications | Applied Mechanics and Materials

Artigo Revisado por pares

Eugene Chai, Kang G. Shin,

... requirement. In this paper, we design and implement Aileron, a novel control channel based on automatic modulation ... the modulation rate of the OFDM subcarriers. With Aileron, the control information is embedded into the modulation ... little to no frame synchronization. We have evaluated Aileron using both extensive simulations and real-world measurements, ... in realistic networking scenarios, we also show how Aileron can be used in conjunction with a fine- ...

Tópico(s): Energy Harvesting in Wireless Networks

2015 - IEEE Computer Society | IEEE Transactions on Mobile Computing

Artigo Revisado por pares

Erkki Soinne,

... paper describes the state of designing aerodynamically balanced ailerons with a practical application to commuter aircraft, with ... the application of CFD computations to determine the aileron aerodynamic data combined with flight mechanical simulations to study the impact on airplane rolling maneuvers and aileron dynamics. Dynamic response of aileron deflection, airplane roll rate and roll acceleration to ... analysis. A review on the design requirements on ailerons and practical design considerations is presented. The CFD ...

Tópico(s): Aerodynamics and Fluid Dynamics Research

2001 - Elsevier BV | Progress in Aerospace Sciences

Artigo Acesso aberto Revisado por pares

Terrence A. Weisshaar, Changho Nam,

The need for effective aileron power for aircraft lateral control and turning maneuvers dates back to the Wright Brothers and their wing warping concept for ... explored ways to increase the effectiveness of control aileron to generate a roll moment. The basic problem of aileron effectiveness and the interrelationship between structural distortion and ... the control surface is illustrated. A rigid wing/aileron surface will develop the capability to generate increased ...

Tópico(s): Computational Fluid Dynamics and Aerodynamics

1990 - American Institute of Aeronautics and Astronautics | Journal of Guidance Control and Dynamics

Artigo

Wendy Wolfson,

... but the drugs target receptors on thecells’ surfaces.Aileron Therapeutics stabilizes pep-tides by ‘‘stapling’’ them with ... autoimmune, inflam-matory, infectious, and metabolic dis-eases. Aileron was started in 2005 byCEOJosephYanchik,III,usingIPlicensedfrom Verdine ... the Dana-Farber CancerInstitute and Harvard Medical School.Aileron Therapeutics is funded bythe investment arms of four ...

Tópico(s): Ubiquitin and proteasome pathways

2009 - Elsevier BV | Chemistry & Biology