Jennifer C. Sims‐Mourtada, Shirley R. Bruce, Morgan R. McKeller, Roberto Rangel, Liliana Guzmán-Rojas, Kelly Cain, Cristina López, Drazen B. Zimonjic, Nicholas C. Popescu, J Gordon, Miles Wilkinson, Héctor Martínez-Valdez,
We previously showed that the human AKNA gene encodes an AT-hook transcription factor that regulates the expression of costimulatory cell surface molecules on lymphocytes. However, AKNA cDNA probes hybridize with multiple transcripts, suggesting either ... evidence for the latter, as we find that AKNA is encoded by a single gene that spans ... specific manner in lymphoid organs. Many of the AKNA transcripts originate from alternative splicing; others appear to ... from differential polyadenylation and promoter usage. The alternative AKNA transcripts are predicted to encode overlapping protein isoforms, ...
Tópico(s): T-cell and B-cell Immunology
2005 - Mary Ann Liebert, Inc. | DNA and Cell Biology
Xianglian Liu, Deyu Huang, Pu Guo, Qinghua Wu, Menghong Dai, Guyue Cheng, Haihong Hao, Shuyu Xie, Zonghui Yuan, Xu Wang,
... toxin still remained unclear. The new transcription factor AKNA, belonging to AT-hook protein family, is closely associated with inflammation. However, it was unclear how AKNA regulate the expression of inflammatory cytokines, and there was no report on the role of AKNA in T-2 toxin mediated toxicity. Here, we investigated the role of AKNA in T-2 toxin-mediated inflammatory response and GH deficiency and the signal transduction pathway of AKNA. We showed that AKNA regulated by PKA/CREB and NF-κB pathway ...
Tópico(s): Mycotoxins in Agriculture and Food
2017 - Elsevier BV | Toxicology
Joaquín Manzo-Merino, Alfredo Lagunas-Martínez, Carla O. Contreras-Ochoa, Marcela Lizano, Leonardo Josué Castro-Muñoz, Crysele Calderón-Corona, Kirvis Torres-Poveda, Alicia Román-Gonzalez, Rogelio Hernández‐Pando, Margarita Bahena-Román, Vicente Madrid‐Marina,
... findings suggest that the AT-hook transcriptional factor AKNA could play a role in the development of cervical cancer. AKNA is strongly related to the expression of co- ... HPV E6 oncoprotein on the AT-hook factor AKNA. In this work, minimal expression of AKNA in cervical carcinoma compared to normal tissue was ... and 18 to interact with and down-regulate AKNA as well as its co-stimulatory molecule CD40 ... manner. We also found that p53 interacts with AKNA and promotes AKNA expression. Our results indicate that ...
Tópico(s): Virus-based gene therapy research
2018 - Multidisciplinary Digital Publishing Institute | Cancers
Gang Wang, Dan Sun, Wenhui Li, Xin Yan,
The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real- ... chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulated in both GC cell lines ... cases’ data above and RNA-Seq data of AKNA in 354 GC patients and the corresponding clinical- ... obtained from The Cancer Genome Atlas (TCGA), and AKNA expression was found closely related to location, metastasis, ...
Tópico(s): RNA Research and Splicing
2020 - Hindawi Publishing Corporation | BioMed Research International
Gabriela Angélica Martínez‐Nava, Kirvis Torres-Poveda, Alfredo Lagunas-Martínez, Margarita Bahena-Román, M. A. Zurita-Díaz, E Ortíz-Flores, Alejandro Garcı́a-Carrancá, Vicente Madrid‐Marina, Ana I. Burguete-García,
... especially in genes related to the immune response. Akna has been proposed to be one of them, ... the disease is scarce. Supporting the notion of akna as a CC susceptibility gene, we found two ... CC; moreover, we identified an association between high akna expression levels and CC and SIL, but its ... existence of a cis-acting polymorphism, we assessed akna allelic expression imbalance for the alleles of the − ... C allele. Our results support the hypothesis that akna is a CC susceptibility genetic factor and suggest ...
Tópico(s): T-cell and Retrovirus Studies
2014 - Springer Nature | Genes and Immunity
Germán Camargo Ortega, Sven Falk, Pia A. Johansson, Elise Peyre, Loïc Broix, Sanjeeb Kumar Sahu, William G. Hirst, Thomas Schlichthaerle, Camino de Juan Romero, Kalina Draganova, Stanislav Vinopal, Kaviya Chinnappa, Anna Gavranovic, Tugay Karakaya, Thomas Steininger, Juliane Merl‐Pham, Regina Feederle, Wei Shao, Song‐Hai Shi, Stefanie M. Hauck, Ralf Jungmann, Frank Bradke, Vı́ctor Borrell, Arie Geerlof, Simone Reber, Vijay Tiwari, Wieland Β. Huttner, Michaela Wilsch‐Bräuninger, Laurent Nguyen, Magdalena Götz,
... Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother ... promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which ... epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2019 - Nature Portfolio | Nature
Naohiro Tsukamoto, Isao Fujii, Yutaka Ebizuka, Ushio Sankawa,
... actIII probe reveals the presence of a gene, aknA, whose deduced protein product is very similar to ... ActIII protein and other known oxidoreductases. The predicted AknA protein is believed to be responsible for catalyzing ... polyketide to the corresponding secondary alcohol. The predicted AknA protein has a calculated molecular mass of 27, ... in oxidoreductases. Cloning and sequence analysis of the aknA region of the 2-hydroxyaklavinone-producing strain S. ... an alteration in the gene, confirming that the aknA gene is essential for aklavinone biosynthesis.
Tópico(s): Fermentation and Sensory Analysis
1994 - American Society for Microbiology | Journal of Bacteriology
Liming Mao, Peizeng Yang, Shengping Hou, Fuzhen Li, Aize Kijlstra,
... two groups. The decreased expression of CD18 and AKNA transcription factor (AKNA), both being three-fold lower than controls in ... technique. A significantly decreased expression of CD18 and AKNA suggests a role for both proteins in the ...
Tópico(s): Systemic Lupus Erythematosus Research
2011 - Public Library of Science | PLoS ONE
Richard W. Vorder Bruegge, J. W. Head, D. B. Campbell,
... mountain belts morphologically similar to terrestrial orogenic belts. Akna Montes and Freyja Montes are long, linear mountain ... produces a long linear mountain range similar to Akna Montes. Using geologic unit maps and topographic maps ... of these data and observations we suggest that Akna Montes may represent the initial form of compressional ... favor the interpretation that it occurred as the Akna Montes‐like proto‐Maxwell Montes was transported to ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
1990 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Guillermo Perales Ortiz, Ana I. Burguete-García, Jisela Dimas, Margarita Bahena-Román, Víctor H. Bermúdez-Morales, José Moreno, Vicente Madrid‐Marina,
The AKNA gene is part of the 9q32 susceptibility locus for cervical cancer. A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) ... 95% confidence interval 1.35–9.94). Therefore, AKNA appears to be an important genetic factor associated ...
Tópico(s): Cancer-related molecular mechanisms research
2010 - Taylor & Francis | Biomarkers
Anna Jansson, H. Koskiniemi, Pekka Mäntsälä, Jarmo Niemi, G. Schneider,
... Anthracycline Substrates—Aclarubicin (also called aclacinomycin A or AknA) was purchased from Calbiochem, and daunorubicin was from Sigma. AknT was produced from AknA by partial hydrolysis as described (16Niemi J. Ylihonko ... DbrA was prepared by incubating 1 mg of AknA for 2 h at 37 °C in a ... other hand, no new products were observed for AknA or DbrA, indicating that DnrK cannot methylate substrates ...
Tópico(s): RNA modifications and cancer
2004 - Elsevier BV | Journal of Biological Chemistry
Gabriela Hernández‐Molina, José Manuel Rodrı́guez-Pérez, Javier Fernández‐Torres, Guadalupe Lima, Nonanzit Pérez‐Hernández, Alberto López-Reyes, Gabriela Angélica Martínez‐Nava,
... gene polymorphisms (Pro582Ser , Ala588Thr , and C191T) and two AKNA gene polymorphisms (−1372C>A and Pro624Leu) were genotyped ... recessive model adjusted by age and gender, the AKNA −1372C>A polymorphism A/A genotype was associated ... allele and C / T genotype as well as AKNA −1372C>A polymorphism A/A genotype as genetic ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2017 - Hindawi Publishing Corporation | BioMed Research International
Petra Hug, Linda Anderegg, Alexandra Kehl, Vidhya Jagannathan, Tosso Leeb,
... 4 bp deletion, c.2717_2720delACAG, in the AKNA gene encoding the AT-hook transcription factor. It ... homozygous wildtype (n = 67) or heterozygous (n = 18). AKNA modulates inflammatory immune responses. Akna-/- knockout mice die shortly after birth due to ... comparative functional data strongly suggest that the detected AKNA:c.2717_2720delACAG variant caused the observed severe ...
Tópico(s): Genomics and Rare Diseases
2019 - Multidisciplinary Digital Publishing Institute | Genes
Abrahan Ramírez-González, Joaquín Manzo-Merino, Carla O. Contreras-Ochoa, Margarita Bahena-Román, José Manasés Aguilar-Villaseñor, Alfredo Lagunas-Martínez, Yvonne Rosenstein, Vicente Madrid Marina, Kirvis Torres-Poveda,
Human akna encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping ... on the literature regarding the functional role of AKNA according to the evidence found in human and ... PubMed literature search using the following search terms, AKNA OR AKNA ADJ gene OR AKNA protein, human OR AKNA ADJ functions. Observational and experimental articles were considered. ... narrative summary of the evidence was produced. Results: AKNA modulates the expression of CD40 and CD40L genes ...
Tópico(s): T-cell and B-cell Immunology
2021 - Multidisciplinary Digital Publishing Institute | Biomolecules
Yihao Liao, Xuanxuan Zou, Keke Wang, Youzhi Wang, Miaomiao Wang, Tao Guo, Boqiang Zhong, Ning Jiang,
... carried out to analyze the relationship between NFATC1, AKNA and five-TFs combination and overall survival (OS). ... differences in the expression of five TFs (CBX7, AKNA, HDAC4, EBF2 and NFATC1) between bladder cancer and ... of many critical factors.The expression level of AKNA and NFATC1 could serve as independent biomarker to ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2021 - Ivyspring International Publisher | Journal of Cancer
L. Marinangeli, M. S. Gilmore,
The investigated area comprises an arcuate mountain belt, Akna Montes, in Western Ishtar Terra, associated with an ... 3) an orogenic phase including the formation of Akna Montes, and (4) local emplacement of younger plains. ... the amount of crustal shortening associated with the Akna Montes, we considered two end‐members for structural ... bounds on the amount of strain recorded by Akna Montes. The first model yields a shortening value ... the geology and tectonics we observed in the Akna Montes‐Atropos Tessera region.
Tópico(s): Planetary Science and Exploration
2000 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Liming Mao, Peizeng Yang, Shengping Hou, Fuzhen Li, Aize Kijlstra,
... two groups.The decreased expression of CD18 and AKNA transcription factor (AKNA), both being three-fold lower than controls in ... technique.A significantly decreased expression of CD18 and AKNA suggests a role for both proteins in the ...
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2011 - Public Library of Science | PLoS ONE
Jichun Liao, Xiaobo Yang, Yong Li, Fuxing Pei, Pengde Kang, Fabao Gao,
... toxin still remained unclear. The new transcription factor AKNA, belonging to AT-hook protein family, is closely associated with inflammation. However, it was unclear how AKNA regulate the expression of inflammatory cytokines, and there was no report on the role of AKNA in T-2 toxin mediated toxicity. Here, we investigated the role of AKNA in T-2 toxin-mediated inflammatory response and GH deficiency and the signal transduction pathway of AKNA. We showed that AKNA regulated by PKA/CREB and NF-κB pathway ...
Tópico(s): Hormonal and reproductive studies
2013 - Elsevier BV | Joint Bone Spine
Syeda Seema Waseem, Abubakar Moawia, Birgit Budde, Muhammad Tariq, Ayaz Khan, Zafar Ali, Sheraz Khan, Maria Iqbal, Naveed Altaf Malik, Saif ul Haque, Janine Altmüller, Holger Thiele, Muhammad Sajid Hussain, Sebahattin Çırak, Shahid Mahmood Baig, Peter Nürnberg,
... Most of these genes encode centrosomal proteins. Recently, AKNA was recognized as a novel centrosomal protein that regulates neurogenesis via microtubule organization, making AKNA a likely candidate gene for MCPH. Using linkage ... found a frameshift variant in exon 12 of AKNA (NM_030767.4: c.2737delG) that cosegregates with ... which has been shown to be indispensable to AKNA's localization to the centrosome and a normal ... newly ascribed functional features, of the multifaceted protein AKNA for association with MCPH.
Tópico(s): RNA regulation and disease
2021 - Multidisciplinary Digital Publishing Institute | Genes
Tianyun Zhao, Chi Ma, Baopin Xie, Bin Zhao, Wei Wang, Ji‐Bin Liu,
... associated with both genetic and environmental factors. The AKNA gene, located at 9q32, has recently been identified ... loci effects of the significant SNPs within the AKNA gene. Results: Among these eight SNPs evaluated we ... link between the risk of KOA and an AKNA gene polymorphism among persons with a Han Chinese ... elucidate the biological plausibility and genetic architecture of AKNA for KOA susceptibility.
Tópico(s): Cytokine Signaling Pathways and Interactions
2020 - Mary Ann Liebert, Inc. | Genetic Testing and Molecular Biomarkers
J. W. Head, Richard W. Vorder Bruegge, L. S. Crumpler,
Orogenic belt environments (Danu, Akna, Freyja, and Maxwell Montes) in Western Ishtar Terra, Venus, display a range of architectural elements, including (from the center of ...
Tópico(s): Geological and Geochemical Analysis
1990 - American Geophysical Union | Geophysical Research Letters
L. S. Crumpler, J. W. Head, D. B. Campbell,
... location of concentrated horizontal compressional deformation and that Akna and Freyja Montes represent erogenic belts on Venus. ...
Tópico(s): Astro and Planetary Science
1986 - Geological Society of America | Geology
Martin Frey, John Baverstock Saunders, H. Schwander,
... an Al-rich sample. Observed mineral assemblages in AKNa are indicative of the pyrophyllite-paragonite-albite fades. ...
Tópico(s): Geological and Geochemical Analysis
1988 - Geological Society of London | Journal of the Geological Society
Kaj Räty, Jaana Kantola, Anne Hautala, Juha Hakala, Kristiina Ylihonko, Pekka Mäntsälä,
... region included the PKS genes for polyketide ketoreductase (aknA), aromatase (aknE1) and oxygenase (aknX), as well as ...
Tópico(s): Genomics and Phylogenetic Studies
2002 - Elsevier BV | Gene
... models. Maxwell Montes and three other deformation belts (Akna, Freyja, and Danu montes) surround the highland plateau ...
Tópico(s): Geological formations and processes
1994 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Lis Jakobsen, Katja Vanselow, Marie Skogs, Yusuke Toyoda, Emma Lundberg, Ina Poser, Lasse Gaarde Falkenby, Martin V. Bennetzen, Jens Westendorf, Erich A. Nigg, Mathias Uhlén, Anthony A. Hyman, Jens Andersen,
... satellites, spindle poles HPA: centrosomal with some satellites AKNA 2.7 — 86 CCDC21 CEP85 2.3 × × 83 ...
Tópico(s): Plant nutrient uptake and metabolism
2011 - Springer Nature | The EMBO Journal
Alison R. Moliterno, Linda Resar,
Tópico(s): interferon and immune responses
2011 - Springer Nature | Cell Research
Venugopal Chenna, Chaoxin Hu, Dipankar Pramanik, Blake T. Aftab, Collins Karikari, Nathaniel R. Campbell, Seung‐Mo Hong, Ming Zhao, Michelle A. Rudek, Saeed R. Khan, Charles M. Rudin, Anirban Maitra,
... as well as bona fide Hh target genes (Akna, Cltb, and Olig2). Notably, NanoHHI combined with gemcitabine ...
Tópico(s): Epigenetics and DNA Methylation
2011 - American Association for Cancer Research | Molecular Cancer Therapeutics
Wenbin Ma, Blanca Ortíz-Quintero, Roberto Rangel, Morgan R. McKeller, Sara Elisa Herrera-Rodríguez, Eliseo F. Castillo, Kimberly S. Schluns, Mary A. Hall, Huiyuan Zhang, Woong‐Kyung Suh, Hitoshi Okada, Tak W. Mak, Yang Zhou, Michael R. Blackburn, Héctor Martínez-Valdez,
Tópico(s): Immune Cell Function and Interaction
2011 - Springer Nature | Cell Research
Tanmoy Rana, Asit Kumar Bera, Subhashree Das, Debasis Bhattacharya, Diganta Pan, Subrata Das,
... Bengal, India, along with arsenic safe control village, Akna in Hoogli district, West Bengal, India. It is ...
Tópico(s): Heavy Metal Exposure and Toxicity
2012 - SAGE Publishing | Toxicology and Industrial Health