Thomas Hof, Laurent Sallé, Laurent Coulbault, Romain Richer, Joachim Alexandre, René Rouet, Alain Manrique, Romain Guinamard,
The transient receptor potential melastatin 4 (TRPM4) inhibitor 9-phenanthrol reduces action potential duration in rabbit Purkinje fibres but not in ventricle. TRPM4-like single channel activity is observed in isolated rabbit Purkinje cells but not in ventricular cells. The TRPM4-like current develops during the notch and early repolarization phases of the action potential in Purkinje cells.Transient receptor potential melastatin 4 (TRPM4) Ca(2+)-activated non-selective cation channel activity has ...
Tópico(s): Ion channel regulation and function
2015 - Wiley | The Journal of Physiology
Joachim Alexandre, Paul Milliez, René Rouet, Alain Manrique, Stéphane Allouche, Gianfranco Piccirillo, Michele Schiariti, Paolo Emilio Puddu,
Steroid hormones appear to be a key factor in the gender differences in the rates and severity of cardiovascular diseases. Aldosterone and testosterone have typical steroid ring structure, but despite this, they demonstrate very different properties. During acute myocardial ischemia-reperfusion, the deleterious impact of aldosterone is now well established. Conversely, the electrophysiological impact of testosterone in this context remained unknown. We used female rabbit in vitro models and standard ...
Tópico(s): Hormonal Regulation and Hypertension
2015 - Wiley | Fundamental and Clinical Pharmacology
Christiane Niether, Stéphane Faure, Alexis Bordet, Jonathan Deseure, Marian Chatenet, J. Carrey, Bruno Chaudret, Alain Rouet,
Tópico(s): Hydrogen Storage and Materials
2018 - Nature Portfolio | Nature Energy
Diane Valéa, Édouard Tuaillon, Yassine Al Tabaa, François Rouet, Pierre‐Alain Rubbo, Nicolas Méda, Vincent Foulongne, Karine Bolloré, Nicolas Nagot, Philippe Van de Perre, Jean-Pierre Vendrell,
Abstract Background Transmission of human immunodeficiency virus type 1 (HIV-1) through breast-feeding may involve both cell-free and cell-associated virus. This latter viral reservoir remains, however, to be fully explored. CD4 + T cell-associated virus production in breast milk was therefore investigated. Methods The ex vivo spontaneous production of HIV-1 antigen and HIV-1 RNA by CD4 + T cells was measured in paired blood and breast milk samples from 15 HIV-1 infected women treated or not with antiretroviral ...
Tópico(s): Cytomegalovirus and herpesvirus research
2011 - BioMed Central | Retrovirology
Marie‐Laure Chaix, Fran ois Rouet, Kouakou Alain Kouakoussui, Rockiath Laguide, Patricia Fassinou, Crépin Montcho, St phane Blanche, Christine Rouzioux, Philippe Msellati,
Objective: To estimate the frequency of human immunodeficiency virus type 1 (HIV-1) displaying genotypic drug resistance in highly active antiretroviral therapy (HAART)-treated children in Abidjan. Methods: Among the 269 HIV-1-infected children enrolled in the ANRS 1278 prospective observational cohort between October 2000 and September 2003, 115 [median age, 6.35 years (range, 1.2–15)] required treatment and received HAART for at least 6 months. Treatment consisted of 2 nucleoside analogue reverse ...
Tópico(s): HIV/AIDS Research and Interventions
2005 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Pierre De Beaudrap, François Rouet, Patricia Fassinou, Alain Kouakoussui, S. Mercier, René Ecochard, Philippe Msellati,
To analyze the determinants of CD4 change in children during 3 periods: before highly active antiretroviral therapy (HAART), during the first year after HAART initiation, and past 1 year after HAART initiation.One hundred seventy-seven children enrolled in a prospective cohort in Abidjan received HAART during a mean follow-up of 30 months. A linear mixed-effects model was used for the first period, a mixed-effects piecewise model for the second period, and an asymptotic mixed-effects model for long- ...
Tópico(s): HIV-related health complications and treatments
2008 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Franck Chauvat, Philippe Rouet, H. Bottin, Alain Boussac,
Tópico(s): Microbial Community Ecology and Physiology
1989 - Springer Science+Business Media | MGG Molecular & General Genetics
Sandrine Lemoine, René Rouet, Alain Manrique, Jean‐Luc Hanouz,
Lipid emulsions are used in the reversal of local anesthetic toxicity. The aim of this study was to investigate the cellular electrophysiological effects of long-chain triglyceride lipid emulsion (LCTE) on cardiac action potential characteristics and conduction disturbances induced by bupivacaine. Purkinje fibers were dissected from the left ventricle of New Zealand white rabbit hearts and superfused with either Tyrode's solution during 30 min (control group), with bupivacaine 10(-6) M, 10(-5) M, ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2013 - Wiley | Fundamental and Clinical Pharmacology
Patricia Fassinou, Narcisse Elenga, François Rouet, Rockiath Laguide, Kouakou Alain Kouakoussui, Marguerite Timite, Stéphane Blanche, Philippe Msellati,
To describe the effect of highly active antiretroviral therapy (HAART) in HIV-1-infected African children.Observational ANRS 1244 cohort of 159 children with HIV between October 2000 and September 2002; 78 children (49%) receiving HAART were followed for a mean duration of 21 months.Weight-for-age Z-scores (WAZ), height-for-age Z-scores (HAZ), CD4 lymphocyte count and HIV-1 RNA viral load were measured before initiating HAART and every 6 months during treatment. Probability of survival and incidences ...
Tópico(s): HIV/AIDS drug development and treatment
2004 - Lippincott Williams & Wilkins | AIDS
Jean‐François Rouet, Eduardo Vidal‐Abarca, Alain Bert Erboul, Victor Millogo,
Two experiments investigated the effects of information search tasks on university students' comprehension of a scientific text. In both experiments, undergraduate students read a 2,000-word introductory text on atomic models; then they searched through the text to answer a series of high-level or low-level questions. Finally, they wrote a 1-page summary of the text. In Experiment 1, high-level questions promoted a review-and-integrate search pattern, whereas low-level questions triggered a locate- ...
Tópico(s): Information Retrieval and Search Behavior
2001 - Taylor & Francis | Discourse Processes
... gelatinase secretion by neonatal alveolar macrophagesChristophe Delacourt, Patricia Rouet-Benzineb, Christophe Delclaux, Jeannique L’Hour, Alain Harf, and Chantal Lafuma1 November 1997 | American Journal ...
Tópico(s): Medicinal Plant Pharmacodynamics Research
1993 - American Physiological Society | Physiological Reviews
Dorothy E. Croall, George Demartino,
... gelatinase secretion by neonatal alveolar macrophagesChristophe Delacourt, Patricia Rouet-Benzineb, Christophe Delclaux, Jeannique L’Hour, Alain Harf, and Chantal Lafuma1 November 1997 | American Journal ...
Tópico(s): Neurological diseases and metabolism
1991 - American Physiological Society | Physiological Reviews
Laurence Lucats, Laurent Vinet, Alain Bizé, Xavier Monnet, Didier Morin, Jin Bo Su, Patricia Rouet‐Benzineb, Olivier Cazorla, J J Mercadier, Luc Hittinger,
... Xavier Monnet, Didier Morin, Jin Bo Su, Patricia Rouet-Benzineb, Olivier Cazorla, Jean-Jacques Mercadier, Luc Hittinger, Alain Berdeaux, Bijan Ghaleh. Objectives: Late preconditioning reduces contractile ...
Tópico(s): Cardiovascular Function and Risk Factors
2006 - Oxford University Press | Cardiovascular Research
Sandrine Lemoine, Katrien Blanchart, Mathieu Souplis, Adrien Lemaître, Damien Legallois, Laurent Coulbault, Christophe Simard, Stéphane Allouche, Jacques H. Abraini, Jean‐Luc Hanouz, René Rouet, Laurent Sallé, Romain Guinamard, Alain Manrique,
Background and Purpose: Cardioprotection against ischemia–reperfusion (I/R) damages remains a major concern during prehospital management of acute myocardial infarction. Noble gases have shown beneficial effects in preconditioning studies. Because emergency proceedings in the context of myocardial infarction require postconditioning strategies, we evaluated the effects of argon in such protocols on mammalian cardiac tissue. Experimental Approaches: In rat, cardiac I/R was induced in vivo by transient ...
Tópico(s): Cardiac Arrest and Resuscitation
2017 - SAGE Publishing | Journal of Cardiovascular Pharmacology and Therapeutics
Sophie Claeyssens, Fatima Banine, Philippe Rouet, Alain Lavoinne, Jean‐Philippe Salier,
An increased hepatocellular hydration state (HS) that can be induced by hypotonic stress or a high glutamine uptake modulates the transcription of given genes in liver. This could be important in the acute phase (AP) of a systemic inflammation where both HS and glutamine uptake transiently increase in liver. In HepG2 hepatoma cells cultured in conditions of hypotonic stress or a high extracellular glutamine availability, a specifically decreased expression of two human mRNAs, namely those of α1‐microglobulin/ ...
Tópico(s): Heat shock proteins research
1998 - Wiley | FEBS Letters
Joachim Alexandre, Thomas Hof, Paolo Emilio Puddu, René Rouet, Romain Guinamard, Alain Manrique, Farzin Beygui, Laurent Sallé, Paul Milliez,
In ST elevation myocardial infarction (STEMI) context, clinical studies have shown the deleterious effect of high aldosterone levels on ventricular arrhythmia occurrence and cardiac mortality. Previous in vitro reports showed that during ischemia-reperfusion, aldosterone modulates K+ currents involved in the holding of the resting membrane potential (RMP). The aim of this study was to assess the electrophysiological impact of aldosterone on IK1 current during myocardial ischemia-reperfusion. We used ...
Tópico(s): Receptor Mechanisms and Signaling
2015 - Public Library of Science | PLoS ONE
Joachim Alexandre, Paolo Emilio Puddu, Christophe Simard, Thomas Hof, Laurent Sallé, Romain Guinamard, Alain Manrique, René Rouet, Farzin Beygui, Paul Milliez,
To assess the electrophysiological impact of aldosterone during myocardial ischemia-reperfusion.We used an in vitro model of "border zone" using rabbit right ventricle and standard microelectrodes.Aldosterone (10 and 100 nmol/L) shortened ischemic action potential [action potential duration at 90% of repolarization (APD90), from 55 ± 3 to 39 ± 1 ms and 36 ± 3 ms, respectively, P < 0.05] and induced resting membrane potential (RMP) hyperpolarization in the nonischemic zone (from -83 ± 1 to -93 ± 7 mV and -94 ± 3 mV, respectively, ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2014 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Jonaz Font, Mathilda Simeon, Christophe Simard, Stéphane Allouche, Anne‐Flore Plane, Virginie Ferchaud, Marie Brionne, René Rouet, Marie Nowoczyn, Alain Manrique, Paolo Emilio Puddu, Paul Milliez, Joachim Alexandre,
Whether oral anticoagulants, vitamin K antagonists (VKAs), and nonvitamin K oral anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute rabbit model of superfused pulmonary veins (PVs) sleeves preparations using standard microelectrode technique. Fluindione 10 μm (n = 6) increased the AP (action potential) duration (APD), induced a significantly ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2018 - Wiley | Fundamental and Clinical Pharmacology
Boubacar Nacro, Emmanuelle Zouré, Hervé Hien, Hassane Tamboura, François Rouet, Adama Ouiminga, Ali Drabo, Souleymane Yaméogo, Alain Hien, Hélène Peyrière, Olivier Mathieu, Déborah Hirt, Jean‐Marc Tréluyer, Joëlle Nicolas, Vincent Foulongne, Michel Segondy, Philippe Van de Perre, Serge Diagbouga, Philippe Msellati,
Abstracts in ,عريب 中文, Français, Pусский and Español at the end of each article
Tópico(s): HIV/AIDS Research and Interventions
2011 - World Health Organization | Bulletin of the World Health Organization
Dramane Kania, Lassana Sangaré, Jean Sakandé, Abdoulaye Koanda, Yacouba Nébié, Oumarou Zerbo, Alain Wilfried Combasséré, Innocent Pierre Guissou, François Rouet,
In Africa where blood-borne agents are highly prevalent, cheaper and feasible alternative strategies for blood donations testing are specifically required.From May to August 2002, 500 blood donations from Burkina Faso were tested for hepatitis B surface antigen (HBsAg), human immunodeficiency virus (HIV), syphilis, and hepatitis C virus (HCV) according to two distinct strategies. The first strategy was a conventional simultaneous screening of these four blood-borne infectious agents on each blood donation ...
Tópico(s): HIV, Drug Use, Sexual Risk
2009 - Wiley | Transfusion
The Becchi–Rouet–Stora–Tyutin (BRST) structure of polynomial Poisson algebras is investigated. It is shown that Poisson algebras provide nontrivial models where the full BRST recursive procedure is needed. Quadratic Poisson algebras may already be of arbitrarily high rank. Explicit examples are provided, for which the first terms of the BRST generator are given. The calculations are cumbersome but purely algorithmic, and have been treated by means of the computer algebra system reduce. Our analysis ...
Tópico(s): Nonlinear Waves and Solitons
1994 - American Institute of Physics | Journal of Mathematical Physics
Joachim Alexandre, René Rouet, Paolo Emilio Puddu, Farzin Beygui, Alain Manrique, Paul Milliez,
To compare the acute ability of amiodarone and dronedarone (a noniodinated benzofuran derivative with a pharmacologic profile similar to amiodarone) to prevent premature ventricular contractions (PVCs) occurrence.We used an in vitro model of rabbit right ventricle mimicking the "border zone" existing between normal and ischemic/reperfused regions to test acute electrophysiological effects of dronedarone and amiodarone both at 1 and 10 μmol/L.Similar to amiodarone, dronedarone affected action potential ...
Tópico(s): Cardiac Arrhythmias and Treatments
2013 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Joachim Alexandre, Farzin Beygui, Paolo Emilio Puddu, Alain Manrique, René Rouet, Paul Milliez,
Introduction: Recent clinical studies have reported the potential benefit of an early mineralocorticoid receptor (MR) blockade with potassium canrenoate (PC) on ventricular arrhythmias (VAs) occurrence in patients experiencing an ST-segment elevation myocardial infarction (STEMI). However, most of the electrophysiological properties of PC demonstrated to date have been investigated in normoxic conditions, and therefore, in vitro experiments during an acute myocardial ischemia–reperfusion were lacking. ...
Tópico(s): Heart Failure Treatment and Management
2014 - SAGE Publishing | Journal of Cardiovascular Pharmacology and Therapeutics
Jérémy Rouet, Sébastien Gaujoux, Maxime Ronot, Maxime Palazzo, François Cauchy, Valérie Vilgrain, Jacques Belghiti, Dermot O’Toole, Alain Sauvanet,
Obstructive jaundice is a frequent symptom most frequently resulting from choledocolithiasis or pancreatico-biliary and periampullary tumors. If duodenal diverticula are frequently asymptomatic, they can occasionally present with obstructive jaundice in the absence of lithiasis or another obstructing lesion such as a tumor in a presentation called Lemmel's syndrome. We herein present a 70-year-old male with obstructive jaundice secondary to a periampullary duodenal diverticulum associated with hepatic ...
Tópico(s): Gastrointestinal disorders and treatments
2012 - Elsevier BV | Clinics and Research in Hepatology and Gastroenterology
Catherine Seyler, Xavier Anglaret, Nicole Dakoury-Dogbo, Eugène Messou, Siaka Touré, Christine Danel, Nafissa Diakité, Alain Daudié, André Inwoley, Chantal Maurice, Besigin Tonwe‐Gold, François Rouet, Thérèse N’Dri-Yoman, Roger Salamon,
To evaluate survival, morbidity, and CD4 and viral load (VL) evolution in HIV-infected adults receiving antiretroviral therapy (ART) in Côte d'Ivoire.Since 1996, 723 HIV-infected adults have been followed up in the ANRS 1203 cohort study in Abidjan. For those patients who received ART, we describe data between ART initiation and August 2002.One-hundred-and-one adults (61% women) were followed up under ART for a median of 17 months. At ART initiation, median age, CD4 count and VL were 36 years, 135/ ...
Tópico(s): HIV/AIDS drug development and treatment
2003 - SAGE Publishing | Antiviral Therapy
... Karadec et sa maitresse Édith Forest, son second Alain Rouet et sa sœur Valentine. À ces cinq personnages ...
Tópico(s): Historical and Literary Studies
2018 - American Association of Teachers of French | The French review
... Karadec et sa maitresse Édith Forest, son second Alain Rouet et sa sœur Valentine. À ces cinq personnages ...
Tópico(s): French Urban and Social Studies
2018 - American Association of Teachers of French | The French review
David I. Campbell, Mitchell J. Feigenbaum, Erhard Seiler, D. L. Stein,
... ferromagnets). His work on these instanton gases with Alain Rouet provided a complete calculation showing that these infrared ...
Tópico(s): Geophysics and Gravity Measurements
2002 - AIP Publishing | Physics Today
Makoura Barro, Jérôme W. Somé, Vincent Foulongne, Yaya Diasso, Emmanuelle Zouré, Hervé Hien, François Rouet, Segondy Michel, Aly Drabo, Hassane Tamboura, Adama Ouiminga, Serge Diagbouga, Alain Hien, Souleymane Yaméogo, Philippe Van de Perre, Boubacar Nacro, Philippe Msellati,
Access to antiretroviral therapy (ART) and routine laboratory monitoring are limited for HIV-1-infected children from sub-Saharan Africa. This trial conducted in Bobo-Dioulasso, Burkina Faso, aimed to describe the biological efficacy, tolerance, and adherence of the combination of didanosine, lamivudine, efavirenz in once-daily administration among eligible HIV-1-infected children. From February 2006 to November 2007, 51 HIV-1-infected children aged from 30 months to 15 years and eligible for ART ...
Tópico(s): HIV Research and Treatment
2011 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Matthieu Berry, Michel Galinier, Clément Delmas, Pauline Fournier, Franck Desmoulin, Annie Turkieh, Harald Mischak, William Mullen, Manon Barutaut, Luc W.M. Eurlings, Sandra van Wijk, Hans‐Peter Brunner‐La Rocca, Céline Caubère, Javed Butler, Jérôme Roncalli, Maria Francesca Evaristi, Alain Cohen‐Solal, Marie‐France Seronde, R. Escamilla, Jean Ferrières, François Koukoui, Fatima Smih, Philippe Rouet,
Diagnostic biomarkers for heart failure (HF) such as the natriuretic peptides (NPs) are widely used but have limitations. Innovative biomarkers could provide improved diagnostic performance. We launched a prospective case–control proteomic study and investigated for polypeptides specific to HF through a capillary electrophoresis-mass spectrometry (CE-MS) proteomic analysis. The putative biomarker was identified by Orbitrap liquid chromatography-MS, validated by western blot, then by ELISA using plasmas ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2014 - Elsevier BV | IJC Metabolic & Endocrine