FROM OUR MILITARY REPORTER, FROM OUR MEDICAL CORRESPONDENT, FROM OUR CORRESPONDENT, FROM OUR DIPLOMATIC CORRESPONDENT, FROM OUR OWN CORRESPONDENT, From Our Political Correspondent, From Our Own Correspondent, From Our Special Correspondent, From Our Shipping Correspondent, From Our Labour Correspondent, R. W. S. MENDL., STEPHEN WILLIAMS. 65, Portland Place, W. 1, May 25., H. H. SYMONDS, Chairman, Friends, OWEN CLOUGH. Queen's Hotel, Eastbourne, May 24., E. G. YORATH., ALAN C. TOD. F. W. DWELLY, Anneal Chairmen, R. A. GREEN. Comptroller's Department, County Hall, S. E. 1., A. E. TIFFIN, Acting General Secre-, E. BAKER. 9, Gordon Road, Chingford, E. 4., ROYSTON MORLEY. Broadcasting House, W. 1, May 26., FROM A CORRESPONDENT, BY OUR MUSIC CRITIC, REGINALD HILL, late Chairman, JOSEPH W. KIWANUKA, A. K. MAYANJA, for and on behalf, C. BARCLAY, Honorary Secretary., From Our Cricket Correspondent, FROM A STAFF REPORTER, FROM OUR EQUESTRIAN CORRESPONDENT, FROM OUR RACING CORRESPONDENT, FROM OUR LAWN TENNIS CORRESPONDENT, FROM OUR GOLF CORRESPONDENT, FROM LLOYD'S,
... R. P. Colomb, Miss L. M. Phillips, Signor Alberto Ascari A Great Racing Motorist, Captain E. R. Joicey, ...
1955 - Gale Group | TDA
Giovanni Grignani, P. Gobbi, Roberto Formisano, Carla Pieresca, G. Ucci, Silvia Brugnatelli, Alberto Riccardi, E Ascari,
The current prognostic systems have failed to identify multiple myeloma (MM) patients who require aggressive therapy. These staging systems do not reliably distinguish patients with different prognoses. This paper explores the possibility of improving the prognostic forecast in MM by considering some clinical characteristics at diagnosis together with response to first-line chemotherapy. A total of 231 patients were prospectively randomised in a multicentre trial to no therapy vs melphalan + prednisone ( ...
Tópico(s): Peptidase Inhibition and Analysis
1996 - Springer Nature | British Journal of Cancer
Steven Shukor, Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Hala Jaber, Robin Cook, Julia Llewellyn Smith, Philip Marsden, Matthew Wall, Barbara Hall, Nigel Botherway, N J, Francois Pienaar, Jon Swain, Robin Butler, Helen Davies, Peter Whittle, Sally Brock, Dan Pearson, John Peter, Professor Gideon Garter, William Lewis Business Editor, Dr Ken Tindell, Jonathan Miller, Jim Munro football editor, Andrew Longmore, Will Baker, Gerald Froyd, Frank Whitford, Ivo Tennant, Ferdinand Mount, Sarah Freeman, Kathryn Cooper, P D, David Smith, Andy Woodman, David Fishel, Steven Poole, David Cracknell Political Editor, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Chrissy Iley, Susan Dominus, Andrew Porter, Kathy Brewis, C D, A C, Ph B, Tony Allen-Mills, Simon Wilde, D C, Robert Sandall, Martin James, Anthony Sattin, Robert Winnett, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Robert Hewison, Peter Wilson, Brian Johnson Thomas, Rosie Millard, Lawrence Dallaglio, Merryn Somerset Webb, David Dougill, Yehuda Hecht, Rod Savage, Sue Townsend, David Hewson, Cally Law, Carole Tucker, David Bond, Paul Gibbs, Hugh Canning, Geraldine Hackett Education Correspondent, Jeremy Clarkson, Richard Wilson, Andrew Stone, Philip Smith, Edward Porter, David Cairns, Stewart Lee, Michael Portillo, Debbie Taylor, Victoria Segal, Patricia Nicol, Stanley Goldsmith, Matthew Barrett chief executive of Barclays and its next chairman, T O'Connell, Eben Black, Dave Pollard, Geoff Carter, Lydia Slater, Michael Suthers, Peter Nichols, Paula Robinson, Christine Toomey, Rebecca Lowthorpe, Robin Scott-Elliot, Stuart Wavell, Roger Eglin, Paul Donovan, Mike Yeomans, Peter Hounam, Dawe, Bertram Hesmondhalgh, Roger Gamon, David Hannigan, Andy Trask, Zoe Thomas, Liz Schmitt, Paul Kimmage, Chris Woodhead, Victor Huntrods Brown, Steve Boyd, Jasper Gerard, Derek Clements, Paul Driver, John Humphrys, Richard Brooks, Nigel Burnham, Ian Hawkey, Stuart Andrews, Ben Wootliff, Christopher Morgan, Alex Clark, Simone Baird, Paul Durman, Professor John Adams, David Meredith, Mark Ludlow, Alicia Wyllie, Mark Edwards, David Crystal, Gita Mendis, Dr Geoffrey Myers, Rachel Bridge, Julian Evans, Susan Clark, D R Taylor, Patrick Strudwick, Hugo Barnacle, Professor Lord Julian Hunt, Mark McSherry, Stuart Miles, Christina Lamb, Sean Newsom, Christopher Silverster, Raymond Keene, C L, Gareth Huw Davies, Fiona Morrow, Donal Kennedy, David Cracknell, Stanley Stewart, Phil Hanks, Katrina Manson, Robert Crowther, Cosmo Landesman, Diana Wright, Jim Irvin, D Mathews, Maria Shriver, Stephen Jones, Dominic O'Connell, Barry Flatman, Nick Cain, Colin Blakemore, Lucy Atkins, Natalie Graham, Dr S Vohra, Caroline Donald, Nick Rennison, Rob Ryan, Jessica Brinton, Miranda Seymour, David Walsh, Trevor Lewis, Gareth Southgate, Bryan Appleyard, Stephen Armstrong, John Elliott, Nick MacKinnon, Mark Anstead, Bethan Cole, Victoria O'brien, Richard Woods, Roland White, Alexander Reilly, Sylvie Simmons, Billy Kenny, Shane Watson, Maurice Chittenden, Richard Brooks Arts Editor, Judith O'Reilly, Richard Rae, Ray Hutton, Jon Ungoed-Thomas, Louise Armistead, Jonathan Leake, M E, Clare Francis, David Levin founder of the Capital Group, John Harlow, Colin MCDowell, Godfrey Smith, Baroness Amos, Barry Collins, John Waples, Professor William Chadwick, Jeremy Hart, A A Gill, Alex Pell, Matthew Campbell, John Carey, Peter Rust, Sue Jerham, David Horspool, Salamasina Simons, David Hutcheon, Nick Fielding, Stephen Pettitt, Jim Clark, Jonathan Carr-Brown, Will Iredale, Jonathan Calvert, Jonathan Leake Science Editor, Lewis Stuart, Howard Jacobson, Paul Kearns, Richard Feast, Justin Sparks, Sally Kinnes, Maria McErlane, Tim Webster, Nigel Powell, David Wickers, Naomi Caine, Darren Laverty, Brian Doogan, Ben Dowell, Minette Marrin, John Aizlewood, Clifford Bishop, Mark Hodson, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Shelley Von Strunckel, Hugh Pearman, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, David Smith Economics Editor, Vanya Kewley, Susannah Price, Lauren St John, Jerome Gardner, Anthony Howard, Sarah Baxter, Bob Dwyer, Joanna Simon, David Robertson, Patricia Kaye, Matthew Goodman, India Knight, Sophie Grigson, Kingston Smith, Simon Howard, Nick Meo, Andrew Fra, Jane Flanagan, Julie Deegan, Richard Lewis, Helen Stewart,
... Jack Brabham (1955-70) Stirling Moss (1951-61) Alberto Ascari (1950-55) Niki Lauda (1971-79,1982-85) ...
2003 - Gale Group | Sunday Times HA GDA
Mario Cazzola, Paolo Arosio, Vittorio Belletti, Gaetano Bergamaschi, Laura Dezza, Carmelo Iacobello, Giuseppina Ruggeri, Elisabetta Zappone, Alberto Albertini, Edoardo Ascari,
Serum ferritin has been suggested as a tumor marker in the diagnosis of certain malignancies and for following the activity or dissemination of the malignant process. Since neoplastic tissues generally contain more acidic isoferritins than their normal tissue counterparts, it has also been suggested that the specific assay of such isoferritins in serum may be of particular value in the diagnosis of malignancy. In this work, we have evaluated ferritin concentration in the serum of normal subjects ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
1985 - SAGE Publishing | Tumori Journal
Produção Nacional
Revisado por pares
Jociani Ascari, Sávio Luis Sens, Domingos Sávio Nunes, Alberto Wisniewski, Marcelo Dutra Arbo, V.M. Linck, Paula Lunardi, Mirna Bainy Leal, Elaine Elisabetsky,
Essential oils (EOs) have been reported to possess pharmacological properties, of which those related to the central nervous system have been especially attributed to mono- and sesquiterpenes. Baccharis uncinella DC. (Asteraceae) is used by the Laklaño Indians (Santa Catarina, Brazil) for sedative purposes. Interestingly, the species does not seem to be used medicinally elsewhere in Brazil.This study was designed to compare the composition and sedative properties of B. uncinella EOs obtained closer ( ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2011 - Taylor & Francis | Pharmaceutical Biology
Marco Danova, Vittorio Rosti, Giuliano Mazzini, Maria R. De Renzis, Franco Locatelli, Mario Cazzola, Alberto Riccardi, Edoardo Ascari,
Abstract Bone‐marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony‐stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most cytostatic drugs selectively damage cycling cells. The safest interval between CSF discontinuation and the start of the next CT course needs to be ascertained in vivo . Thirty patients ...
Tópico(s): Cancer Cells and Metastasis
1995 - Wiley | International Journal of Cancer
Carlomaurizio Montecucco, Alberto Riccardi, Giampaolo Merlini, Edoardo Ascari,
S ummary . Two patients with primary plasma cell leukaemia who achieved complete remission are reported. They were treated with induction therapy consisting of a multipeptide derivative of sarcolysin, Peptichemio, given intravenously, combined with vincristine and/or prednisone, followed by conventional melphalan‐prednisone therapy. 5–7 months following the beginning of therapy, both patients attained a complete remission which lasted 23 and 6 months; second remission was not achieved. Survival from ...
Tópico(s): Protein Degradation and Inhibitors
1986 - Wiley | British Journal of Haematology
G. Ucci, Alberto Riccardi, R Luoni, E Ascari,
Abstract. Objectives . The clinical, laboratory and radiologic features at diagnosis of 684 newly diagnosed patients with monoclonal gammopathy were revised in order to underline the differences between monoclonal gammopathies of undetermined significance (MGUS) and stage I multiple myeloma (MM). Design . Patients were screened for inclusion in a prospective controlled protocol for treatment of MM. Those having serum or urine monoclonal component (MC) were diagnosed as MM when they demonstrated osteolysis ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1993 - Wiley | Journal of Internal Medicine
Umberto Di Dedda, Marco Ranucci, Alberto Porta, Vlasta Bari, Alice Ascari, Angela Fantinato, Ekaterina Baryshnikova, Mauro Cotza,
Cardiac surgery with cardiopulmonary bypass is associated with important changes in the microcirculation, usually attributed to endothelial dysfunction. Another common finding of cardiac surgery is postoperative thrombocytopenia and platelet loss of function.To investigate the association between microvascular flow pattern and postoperative changes in platelet count and function in cardiac surgery patients.Twelve adult cardiac surgery patients received microvascular circulation (sidestream darkfield ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2018 - IOS Press | Clinical Hemorheology and Microcirculation
James Glasbey, Tom Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab Alameer, Sattar Alshryda, Alexis Arnaud, Brittany Bankhead-Kendall, Mohamad K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas‐Chavarri, Miguel F Cunha, Justine Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J.E.F. Fitzgerald, Maria Fourtounas, Alexander J. Fowler, K Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter J. Hutchinson, Gabriella Hyman, Arda Işık, Umesh Jayarajah, Haytham M.A. Kaafarani, Bryar Kadir, Ismaïl Lawani, Hans Lederhuber, Elizabeth Li, Markus Löffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D McClain, Kenneth A McLean, John G. Meara, Antonio Ramos‐De la Medina, Mengistu G Mengesha, Ana Minaya, María Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert M. Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabriëlle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana F F Simoes, Neil Smart, Richard Sullivan, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H Taylor, Mary L Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu, Omar Omar, Ewen M. Harrison, Aneel Bhangu, Kwabena Siaw-Acheampong, Ruth Benson, Edward Bywater, Brett E Dawson, Jonathan P Evans, Emily Heritage, Conor Jones, Sivesh K. Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew T. Knight, Samuel Lawday, Harvinder Mann, Ella J Marson, Siobhan C. McKay, Emily Mills, Gianluca Pellino, Abhinav Tiwari, Isobel M Trout, Richard Wilkin, Sadi A. Abukhalaf, Michel Adamina, Adesoji Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeier, Osaid Alser, Muhammad Alshaar, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany Bankhead-Kendall, Emma Barlow, David Beard, Ruth Blanco‐Colino, Amanpreet Brar, Ana Minaya‐Bravo, Kerry Breen, Chris Bretherton, Igor Lima Buarque, Josh Burke, Edward Caruana, Mohamad K. Abou Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moisés Cukier, Giana H. Davidson, Salomone Di Saverio, Thomas M Drake, John Edwards, Sameh Hany Emile, Shebani Farik, Samuel Ford, Tatiana Garmanova, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A. Griffiths, Magdalena Gruendl, Constantine Halkias, Intisar Hisham, Peter J. Hutchinson, Shelley Hwang, Michael D. Jenkinson, Pascal Jonker, Debby Keller, Angelos G. Kolias, Schelto Kruijff, Sezai Leventoğlu, Andrey Litvin, Andrew P. Loehrer, María Marta Modolo, Piotr Major, Hassan Mashbari, Symeon Metallidis, Helen Mohan, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionuț Negoi, Milagros Niquen-Jimenez, Maricarmen Olivos, Salah Eddine Oussama Kacimi, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Carlos J. Pérez-Rivera, Thomas Pinkney, Willemijn Y. van der Plas, Ahmad Uzair Qureshi, Dejan Radenković, Antonio Ramos‐De la Medina, Elliot John Revell, Keith Roberts, April Camilla Roslani, Martin Rutegård, Juan José Segura‐Sampedro, Irène Santos, Andrew Schache, Andreas A. Schnitzbauer, Justina O. Seyi‐Olajide, Neil Sharma, Caitlin Shaw, Sebastian Shu, Kjetil Søreide, Antonino Spinelli, Grant D. Stewart, Philip Townend, Georgios Tsoulfas, Raghavan Vidya, Dale Vimalachandran, Oliver Warren, Duane Wedderburn, NA EuroSurg, NA European Society of Coloproctology, NA Global Initiative for Children's Surgery, NA GlobalSurg, NA GlobalPaedSurg, NA ItSURG, NA PTSurg, NA SpainSurg, NA Italian Society of Colorectal Surgery, NA Association of Surgeons in Training, NA Irish Surgical Research Collaborative, NA Transatlantic Australasian Retroperitoneal Sarcoma Working, NA Italian Society of Surgical Oncology, Lesley Booth, Margaret Barker, Neil Barker, Shirley Cooke, Suzanne Doré, Nigel Horwood, Emmy Runigamugabo, Carrie Tierney Weir, Mike Bahrami-Hessari, Asad Riaz, Jaffer Shah, Mohammed Safi, Dariel Thereska, Irida Dajti, Riadh Cheddadi, Anisse Tidjane, Carlos A Quinteros, Ahmed khelfaoui, Kamel Ben Salem, Omar Riffi, Salah Eddine Oussama Kacimi, Salim Loudjedi, Tidjani Damerdji, Diana Alejandra Pantoja Pachajoa, René M. Palacios Huatuco, Fernando A. Alvarez, Alejandro Marcelo Doniquian, Roberto Ariel Abeldaño Zúñiga, Francisco Schlottmann, C. Cobos, Cecilia Gigena, Agustin Albani Forneris, Agustín Duro, Agustín García-Mansilla, Virginia Cano Busnelli, C. Poggi, Pedro Mercado, Marcos González, Agustina F Castro Lalin, Horacio F. Mayer, Rodrigo Brandariz, Pablo A. Slullitel, Rocio Boudou, Pablo Lobos, María C Uffelmann, María Laura Petersen, Emilia Luzzi, F. Lichtenberger, María Amor, Celeste S Zarratea, Tomás Alfredo Esteves, Nicolas A Gemelli, Sebastián Tirapegui, Juan Liyo, Jordán Scherñuk, Luis Alejandro Boccalatte, Rubén Balmaceda, José Luis D’addino, M. Caubet, José Alfredo Calderón Arancibia, Carina Chwat, Brian Morris, Nicolás Avellaneda, Ivana Ines Pedraza Salazar, D Eskinazi, Lara Vargas, María Emilia Muriel, Stefano Lucchini, M. Gosselink, Amelia Davis, J. Barker, Kirby R. Qin, David Proud, Daniel Cox, Su Kah Goh, David S. Liu, Dan Wu, Neil D. Merrett, Sarit Badiani, Shomik Sengupta, Anshini Jain, Christopher Steen, Enoch Wong, C Ip, Matthew Leaning, Conor McCartney, Sivakumar Gananadha, Evie Yeap, Sean Stevens,
The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
Elsevier BV
Camillo Porta, Marco Danova, Alberto Riccardi, E Bobbio-Pallavicini, Edoardo Ascari,
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
1999 - Elsevier BV | Mayo Clinic Proceedings
Marco Danova, Camillo Porta, Silvia Ferrari, Silvia Brugnatelli, Giuditta Comolli, Alberto Riccardi, E Ascari,
Paclitaxel and its analogue docetaxel show a significant antitumor activity, particularly evident in breast cancer. Paclitaxel has also been proved to be effective as a peripheral blood progenitor cell (CPC) mobilizing agent. To optimize the use of active, disease-specific drugs as CPC priming, we have evaluated the effects of either paclitaxel or docetaxel both at standard dosages and followed by granulocyte colony-stimulating factor (G-CSF), on circulating CPC release and function in 18 patients ...
Tópico(s): Lung Cancer Research Studies
2000 - Elsevier BV | Oncology Reports
Lara González-Villanueva, Alberto Alvarez-Alvarez, Luca Ascari, Gracián Triviño,
In this paper, human motion analysis is performed by modeling a physical complex exercise in order to provide feedback about the patient's performance in rehabilitation therapies. The Sun Salutation exercise, which is a flowing sequence of 12 yoga poses, is analyzed. This exercise provides physical benefits as improving the strength and flexibility of the muscles and the alignment of the spinal column. A temporal series of measures that contains a numerical description of this sequence is obtained ...
Tópico(s): Rough Sets and Fuzzy Logic
2013 - Elsevier BV | Applied Soft Computing
Carlo L. Balduini, Luigi Gugliotta, Mario Luppi, Luca Laurenti, Catherine Klersy, Carla Pieresca, Gerlando Quintini, Francesco Iuliano, Rossana Re, Pierangelo Spedini, Nicola Vianelli, Alfonso Zaccaria, Enrico Maria Pogliani, R Musso, E. Bobbio Pallavicini, Giovanni Quarta, Piero Galieni, Alberto Fragasso, Gianluca Casella, Patrizia Noris, Edoardo Ascari,
Therapeutic plasma exchange (PE) is the accepted therapy for thrombotic thrombocytopenic purpura (TTP). Because not all patients achieve remission, other treatment modalities have been used in addition to PE, but no randomized clinical trial evaluated their efficacy. The aim of this multicentric study was to compare the effectiveness of standard- versus high-dose methylprednisolone as an adjunctive treatment to PE in the acute phase of TTP. Sixty patients with idiopathic TTP were randomized to receive ...
Tópico(s): Blood groups and transfusion
2009 - Springer Science+Business Media | Annals of Hematology
Silvia Ferrari, Marco Danova, Camillo Porta, Giuditta Comolli, Silvia Brugnatelli, Palma Pugliese, Alberto Riccardi, E Ascari,
Topotecan is a new antineoplastic agent active in ovarian cancer, with promising activity in small cell lung cancer and predictable toxicity. As a part of our ongoing attempt to optimize the use of disease-specific drugs as circulating progenitor cell (CPC) priming in solid tumors, we have evaluated the effects on CPC release of single-agent Topotecan followed by granulocyte colony-stimulating factor (G-CSF) + human recombinant erythropoietin (rhEPO), together with the cell cycle status of the collected ...
Tópico(s): Ovarian cancer diagnosis and treatment
1999 - Spandidos Publishing | International Journal of Oncology
Paolo G. Gobbi, Daniele Bertoloni, Giovanni Grignani, Carla Pieresca, Andrea Rossi, Leonardo Rutigliano, Giampaolo Merlini, Alberto Riccardi, Edoardo Ascari,
From a retrospective multivariate study on 107 multiple myeloma (MM) patients, serum beta 2-microglobulin (beta 2M) proved to be the best prognostic discriminator, better than each of the currently used staging systems (Durie and Salmon's [DS], Merlini, Waldenström and Jayakar's [MWJ] and the British Medical Research Council's [BMRC]). The predictive ability of each staging system is better improved by combining consideration of beta 2 M as a continuous rather than a binary variable (even at its best prognostic ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1991 - Wiley | European Journal Of Haematology
Anna Mara Scandroglio, Gabriele Finco, Marina Pieri, Roberto Ascari, Maria Grazia Calabrò, Daiana Taddeo, Francesca Isella, Annalisa Franco, Mario Musu, Giovanni Landoni, Ottavio Alfieri, Alberto Zangrillo,
The elderly undergo cardiac surgery more and more frequently, often present multiple comorbidities, assume chronic therapies, and present a unique physiology. Aim of our study was to analyze the experience of a referral cardiac surgery center with all types of cardiac surgery interventions performed in patients ≥80 years old over a six years' period. A retrospective observational study performed in a university hospital. 260 patients were included in the study (3.5% of the patients undergoing cardiac ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2015 - BioMed Central | BMC Anesthesiology
Erica Liverani, Alessandro Fortunato, Alberto Leardini, Claudio Belvedere, Sorin Siegler, Lorella Ceschini, Alessandro Ascari,
A study of Cobalt–Chromium–Molybdenum endoprosthetic ankle implant fabrication by means of SLM is presented, including process characterization and kinematic considerations. Process optimization is first performed on samples with simple geometry to maximize density and mechanical strength using Co–Cr–Mo powders. Parameters such as laser scanning velocity, laser power and scanning strategy are varied, amongst others. Mechanical tests and microstructural analyses are performed to define process parameter ...
Tópico(s): Orthopaedic implants and arthroplasty
2016 - Elsevier BV | Materials & Design
Giampaolo Merlini, Giuseppe Attardo Parrinello, L Piccinini, Francesca Crema, M Fiorentini, Alberto Riccardi, Franco Pavesi, F Novazzi, Vittorio Silingardi, Edoardo Ascari,
Data on the long-term treatment of myeloma bone disease with bisphosphonates are scanty. In a prospective pilot trial we evaluated the effect of long-term parenteral administration of dichloromethylene bisphosphonate (Clodronate), in addition to standard chemotherapy, in 30 patients with active myeloma bone disease. Patients were treated with a mean of 4 courses (range 2-8) of Clodronate: 300 mg/day i.v. for seven days followed by 100 mg/day i.m. for 10 days, administered at a mean interval of 4 months ( ...
Tópico(s): Peptidase Inhibition and Analysis
1990 - Wiley | Hematological Oncology
Carlomaurizio Montecucco, Alberto Riccardi, Egidio Traversi, Paolo Giordano, Giuliano Mazzini, Edoardo Ascari,
The proliferative activity of bone marrow cells was studied in 24 patients with primary dysmyelopoiesis by means of flow cytometry and 3H-IdR autoradiography. Abnormal DNA content was found in two cases with aneuploid karyotypes. DNA content typical of a diploid population was observed in all patients with normal karyotype and in three patients with chromosomal aberrations. The fraction of bone marrow cells in S-and G2-phase was higher in primary acquired sideroblastic anemia and refractory anemia ( ...
Tópico(s): Prenatal Screening and Diagnostics
1983 - Wiley | Cancer
Giammaria Sitar, Silvia Garagna, Maurizio Zuccotti, Cristina Falcinelli, L Montanari, Alessandro Alfei, Giovanbattista Ippoliti, Carlo Alberto Redi, Remigio Moratti, Edoardo Ascari, Antonino Forabosco,
Background: Erythroblasts have been the most encouraging candidate cell type for noninvasive prenatal genetic investigation. We previously showed that human erythroblasts can be recovered from bone marrow and blood bank buffy coats by a physical cell separation. In the present study, we modified our previous methodology, taking into account the peculiar behavior of erythroblasts in response to modifications of pH and osmolality of the separation medium. Methods: Twenty to forty milliters of cord ...
Tópico(s): Renal and related cancers
1999 - Wiley | Cytometry
Marco Danova, Gabriele Mazzini, R Alberici, Claudia Lucotti, S. Palmeri, G. Fincato, Mario Cazzola, Alberto Riccardi, E Ascari,
The biological mechanisms by which the association of interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) is expected to effectively reduce the hematological toxicity associated with chemotherapy (CT) are not completely elucidated. We exploited the cell kinetic changes of the bone marrow CD34(+) cell subset after CT followed by the IL-3+GM-CSF together with the clinical effects of this association. Eighteen patients with advanced cancers and normal hematopoiesis were ...
Tópico(s): Immune Cell Function and Interaction
1996 - Spandidos Publishing | International Journal of Oncology
Paola Cavalli, Mario Cazzola, Paolo G. Gobbi, M Gorini, A. Malfitano, Alberto Riccardi, Edoardo Ascari,
A case of Reed-Sternberg (R-S) leukaemia is described, and the results of the morphological, cytochemical and cytokinetic studies on the circulating neoplastic cells are reported. Detailed data are given for each of the 3 types of abnormal circulating cells: abnormal mononuclear (AM) cells, Hodgkin's (H) cells and R-S cells. Our results cannot discriminate whether R-S cells derive from monocyte-macrophages or from B-cell lineage. However, some data suggest that H and R-S cells may likely originate ...
Tópico(s): Glycosylation and Glycoproteins Research
1981 - SAGE Publishing | Tumori Journal
R Luoni, G. Ucci, Alberto Riccardi, Paolo G. Gobbi, Francesco Maria Avato, Claudia Vignale, E Ascari,
Between January 1986 and March 1990, the serum levels of thymidine kinase (TK) were evaluated at diagnosis in 97 patients with monoclonal gammopathy of undetermined significance (MGUS) and 149 patients with multiple myeloma (MM) enrolled in a prospective protocol for treatment of MM. At presentation, patients with MGUS had lower TK levels than those with Stage I MM (P less than 0.05) and the overall population of those with MM (P less than 0.0005). TK levels were increased in advanced stages in comparison ...
Tópico(s): Cancer Treatment and Pharmacology
1992 - Wiley | Cancer
Marco Danova, Alberto Riccardi, Monica Giordano, Margherita Girino, Giuliano Mazzini, Laura Dezza, Edoardo Ascari,
We used 2‐parameter flow cytometry (FCM) to investigate the relationship between the cell cycle phases and 3 proteins whose expression is known to increase in proliferating cells: the surface antigen transferrin receptor Trf‐r), the “cyclin” (a proliferating cell nuclear antigen, PCNA), and the nuclear antigen recognized by the monoclonal antibody (MoAb) Ki‐67. FITC‐labeled antibodies against Trf‐r, PCNA, and the Ki‐67‐reactive antigen, as well as propidium iodide‐DNA distribution, were simultaneously ...
Tópico(s): Gene expression and cancer classification
1988 - Wiley | Biology of the Cell
Carlomaurizio Montecucco, Alberto Riccardi, Giampaolo Merlini, Giuliano Mazzini, Paolo Giordano, Marco Danova, Edoardo Ascari,
In 62 patients with multiple myeloma (MM) and related disorders, the nuclear DNA content distribution of bone marrow plasma cells was assessed by flow and conventional cytofluorometry. Abnormal distributions, suggesting the presence of aneuploid populations, were observed in 53% of MM at diagnosis, in 50% of benign monoclonal gammopathies and in 12% of Waldenström's macroglobulinemias. Eighty-six percent of aneuploid cases had DNA stem-lines falling between the diploid and triploid value. In advanced ...
Tópico(s): Glycosylation and Glycoproteins Research
1984 - Pergamon Press | European Journal of Cancer and Clinical Oncology
Marco Danova, Cesare Perotti, O Mora, Claudia Lucotti, Lorella Torretta, Giuditta Comolli, Alberto Riccardi, L. Salvaneschi, E Ascari,
The feasibility and safety of the administration of multiple cycles of dose-intensive chemotherapy (CT) supported with repeated reinfusions of circulating progenitor cells (CPCs) were evaluated in a prospective study of adjuvant initial therapy of poor-prognosis breast cancer. Eighteen patients with resectable breast cancer involving >/= 10 axillary nodes or >/= 5 axillary nodes and negativity of the estrogen receptor status received a cycle of standard FEC regimen (5-FU 600 mg/m2, epirubicin 60 mg/m2, CTX ...
Tópico(s): Metastasis and carcinoma case studies
1998 - Elsevier BV | Oncology Reports
Alberto Riccardi, G. Ucci, A Coci, E Ascari,
Journal Article Bone Marrow Fibrosis in Multiple Myeloma Get access A. Riccardi, A. Riccardi Department of Internal Medicine Section of Medical Clinic II and Department of Pathology University of Pavia and I.R.C.C.S. Policlinico S. Matteo Pavia, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Ucci, G. Ucci Department of Internal Medicine Section of Medical Clinic II and Department of Pathology University of Pavia and I.R.C.C.S. Policlinico S. Matteo Pavia, Italy ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
1988 - Oxford University Press | American Journal of Clinical Pathology
Marco Danova, Monica Giordano, Eugenio Erba, S. Palmeri, Vincenza Candiloro, Alberto Riccardi, G. Ucci, Giuliano Mazzini, Maurizio D’Incalci, Edoardo Ascari,
Tópico(s): Hepatitis B Virus Studies
1992 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Alberto Riccardi, G. Ucci, R Luoni, A Castello, A Coci, Umberto Magrini, E Ascari,
Between January 1987 and October 1989, 561 consecutive untreated patients with monoclonal gammopathy of undetermined clinical importance (MGUS) (n = 295) or with multiple myeloma (n = 266) were evaluated in a multicentre trial. Both bone marrow biopsy and aspiration (performed at different anatomical sites) were required at presentation. Bone marrow biopsy data indicated that changes in bone marrow composition from MGUS to early multiple myeloma and to advanced multiple myeloma followed a precise pattern, ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
1990 - BMJ | Journal of Clinical Pathology