Waldemar Januszczak, Michael Prescott, Godfrey Hodgson, Patrick French, Barbara Hall, Nigel Botherway, Tony Barrell, Matthew Sturgis, Chris Ryder, John Peter, Emma Moore, Amanda Ursell, John Jay, Ian Borthwick, Demitri Marchessini, Sandra Howard, A S, Ivo Tennant, Thomas Hardy, Nicolette Jones, Graham McKay, Tanla Alexander, Sally Payne, Lucy Hughes-Hallett, David Smith, John Harlow Social Affairs Editor, Tim Richards, Anne Burley, Kirstie Hamilton City Editor, Humphrey Carpenter, Melanie Phillips, Nick Pitt, Robin Dawson, Andrew Sullivan, Clive Davis, Stephen Grey, Vincent Kearney, Dylan Jones, Mary Wilson, C D, Kathy Brewis, Tony Allen-Mills, Simon Wilde, Robert Sandall, Anthony Sattin, Eleanor Mills, Steve Farrar, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, Roger Anderson, David Dougill, Edward porter, John Evans, Anna Bruning, Philip Kingsley, Norman Shepherd, Anne Nigel, Sarah Toyne, David Hewson, Mario Testino, Chris Hastings, Harvey Porlock, Margaret Coles, William Dalrymple, Alasdair Reid, Hugh Mcllvanney, Margarette Driscoll, Nigel Williams, Jeremy Clarkson, Water mills, John Sutherland, Peter Conradi, Hugh Canning, Louise Taylor, John Waples Deputy City Editor, David Cairns, Stewart Lee, Edward Porter, A Laycock, Nick Newman's, Sam Murphy, Douglas Fairbairn, David Eimer, Phil Craigie, Rex Gooch, Graham Otway, Hugh McManners Defence Correspondent, Stella Russell, Nick Gardner, Rupert Widdicombe, Naomi Caine Money Editor, Quentin Letts, Adam Spruce, Phillip Oppenheim, Lorna Macleod, Stuart Wavell, Maggie Gee, Josephine Smit, Paul Donovan, Julia Bueno, Frances Spalding, Caroline Aherne, Rasseias, Eric Nicolis, Sue Lawrence, Simon Mills, Stan Labovitch, Paul Driver, Derek Clements, Gay Bramwich, Simon Fanshawe, Ann McFerran, John Follain, Maeve Sheehan, Steven Downes, Peter Windsor, Ian Hawkey, Shelley Von Strunckel, Caroline Scott, Christopher Morgan, David Leppard, John Eggleston, Robert Crawford, Alicia Wyllie, Dave Hannigan, Mark Edwards, Steve Farrar Science Correspondent, Kirstie Hamilton, Tom Shone, Sarah Gracie, Susan Clark, Stephen Amidon, David Lawrenson, T W, Zoe Brennan Westminster Correspondent, Phil Baker, Sheila Hancock, Dr Eamonn Butler Director, Penny Allen, A J Bell, Nixon McLEAN, Sean Newsom, Sue Reid, Raymond Keene, Chris Oliver Wilson, Zoe Brennan, John Shuttleworth, Marie Colvin, Simon Willis, Diana Wright, Jennie Bristow, Kipper Williams, Paul Watkins, Androw Smith, Michio Kaku, Helen Hawkins, Chris Partridge, Michael Prescott Political Editor, Paul Nuki Consumer Affairs Editor, Stephen Jones, Richard Evans, Nick Cain, Geraldine Lambe, Stephen Bevan, M H, Natalie Graham, Andrew Smith, Paul Nuki, R Grant, Ian Coxon, Jeremy Lewis, Martin Searby, Keith Wheatley, Claire Oldfield, Alun Roderick, David Walsh, Anne Inglis, Trevor Lewis, Jack Grimston, Colin McDowell, Bryan Appleyard, Lois Rogers Medical Correspondent, Mike Longworth, Stephen Armstrong, Jean Spence, Maeve Sheeham, Ron Clarke, Tania Alexander, Paul Kavanagh, Josh Salzmann, Mark Prigg, R W Johnson, Richard Woods, Garth Alexander, D P, Dr Gabriel Jaffe, Steward Lee, Richard Carswell, Janet Street-Porter, Murray Hedgcock, Maurice Chittenden, Kevin Pratt, Andrew Lorenz Business Editor, Chelsea Clinton, Mark Franchetti, Jonathan Powell, Ray Hutton, Jon Ungoed-Thomas, Andrew Rogers, Michael Sheridan, Tim Melville-Ross Director-General, K Mitchelmore, Sean Hargrave, John Harlow, Matthew Lynn, Godfrey Smith, Michael Austin, Donald Macgillivray, Michael Hodges, Mandy Payne, John Waples, Caroline, A A Gill, Eva Gizowska, Matthew Campbell, Brian Glanville, D Spacey, Jeremy Wayne, Simon Hoggart, N W, David caims, Tom Robbins, George Rice, David Hutcheon, Robert Johnston, Stephen Pettitt, K Morrison, T L, Andrew Lorenz, Naomi Caine, David Wickers, Roger Dobson, Tom Rhodes, Nick Gardner Deputy Money Editor, Simon Carnell, Mark Hodson, Nicholas Hellen Media Correspondent, Joe Lovejoy, Rupert Steiner, David Berger, Hugh Pearman, George Stephanopoulos, John Spence, David Parsley, David Smith Economics Editor, Penny Perrick, Tom Deveson, Zoe Linkson, Peter Cooper, Bob Dwyer, Joanna Simon, Victoria, Barry Newcombe, Michael Ward, Boris Schapiro, Karen Robinson,
... Timberland Flooring Company Ltd Nirvana can wait Julia Bueno quit her well-paid job in the City ... 99 pp132 Into the Looking-Glass Wood by Alberto Manguel Bloomsbury £15.99 pp275 Philip Marsden Shortlist ...
1999 - Gale Group | Sunday Times HA GDA
Alberto López-Bueno, Alberto Rastrojo, Ramón Peiró‐Pastor, Miguel Arenas, Antonio Alcamı́,
Abstract RNA viruses exist as complex mixtures of genotypes, known as quasispecies, where the evolution potential resides in the whole community of related genotypes. Quasispecies structure and dynamics have been studied in detail for virus infecting animals and plants but remain unexplored for those infecting micro‐organisms in environmental samples. We report the first metagenomic study of RNA viruses in an Antarctic lake (Lake Limnopolar, Livingston Island). Similar to low‐latitude aquatic environments, ...
Tópico(s): Plant and Fungal Interactions Research
2015 - Wiley | Molecular Ecology
Andrew Robson, Raymond Snoddy Media Editor, Oliver Holt Chief Sports Correspondent, Andrew Pierce, James Moore, Ken Dale-Risk, Sarah Potter, Simon Barnes, Robert Thicknesse, David Rhys Jones, Richard Hobson, Michael Evans Defence Editor, Geoffrey Dalzell-Payne, Lesley Steyn, Philip Howard, Carol Midgley, Hilary Finch, David Pannick, James Bone, Hans Kung Doctor, Elizabeth Judge, Benjamin R. Barber, Director, Charles Bremner and Martin Fletcher, Joseph S. Nye, Jeremy Whittle, Giles Coren, John O'Leary Education Editor, Laura Peek, Helen Johnstone and David Charter, Valerie Elliott Countryside Editor, Ian Caplin, Dominic Walsh, Steve Bird, Debra Craine, Shirley English, Bobby Robson, Alix Ramsay Tennis Correspondent, Dr Jane Collins, Tim Reid, Robert D. Putnam, Professor, Libby Purves, Richard Ford Home Correspondent, Mark Inglefield, John O'Leary, James Landale Political Correspondent, Janet Bush, Miranda Ingram, Julia Bueno, Peter Barnard, Anthea Lawson, Tim Teeman, Patience Wheatcroft Business Editor, Caroline Merrell Banking Correspondent, Jasper Gerard, Daniel McGrory, Paul Armstrong, Edward Fennell, Matt Dickinson Football Correspondent, Frank Leboeuf, Susan Clark, Jill Sherman Whitehall Editor, Gary Slapper, Barry Millington, Dom Peck, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Polly Weitzman, Arthur Leathley and Melissa Kite, Peter A. Hall, Professor, Gavin Cordon, David Powell Athletics Correspondent, Marcus Binney, Stuart Nicholson, Raymond Keene, David Robinson, Michael Shrimpton, Christopher Walker Chief Ireland Correspondent, Chris Ayres Media Business Correspondent, Cathy Harris, Kevin Murray, President, Andrew Anderson, Christopher Martin-Jenkins Chief Cricket Correspondent, Leo Cooper, Richard Food, Vanni Treves, Andrew Drummond and Tim Reid, Martyn Day and Rabinder Singh, Oliver August, Nick Hasell, Christopher Kelly, Julian Muscat, James Collard, Nick Szczepanik, John Goodbody, Susie Steiner Property Correspondent, Philip Webster Political Editor, Alex O'Connell, Craig Lord, Anna Kythreotis, Niall Head-Rapson, Paul McCann Media Correspondent, Kevin McCarra, Melissa Kite Political Reporter, Caitlin Moran, Alan Lee, Peter Riddell, Ben MacIntyre, Stephen Farrell and Michael Evans Defence Editor, Ian Brodie, Michael Gove, Richard Beeston Diplomatic Editor, Bianca Wordley, Graham Searjeant, Nigel Hawkes Science Editor, Stuart Bonar, Carl Mortished International Business Editor, Fran Littlewood, Sophie Petit-Zeman, Daniel Rosenthal, Benedict Nightingale, James Landale and Andrew Pierce, J. G. Boggis, Fiona Bawdon, Adam Howorth, Frances Gibb, Sam Kiley, Adam Sherwin, Tom Baldwin Deputy Political Editor, David McVay and George Caulkin, Robert Whymant, Alan Lee Racing Correspondent, Roger Harris, Lea Paterson Economics Correspondent, Sally Patten, Emma Burns, Fraser Nelson Retail Correspondent, Patience Wheatcroft, Willard A. Workman, Vice-President, Christopher Irvine, Susan Emmett,
... are locked in their own world, says Julia Bueno no title The Times Tuesday July 4 2000 ... choice Times 2 Arts Money doesn't talk Alberto Vllar has so far given away ?100 million ...
2000 - Gale Group | TDA
Fernando Santos, M. Llanos Moreno, A. Paiva Neto, Gema Ariceta, Julia Vara, Ángel Alonso, Alberto Hernández Bueno, Alberto Caldas Afonso, António Jorge Correia, Rafael Muley, Vicente Barrios, Carlos F. Gómez, Jesús Argente,
Our aim was to evaluate the growth-promoting effect of growth hormone (GH) treatment in infants with chronic renal failure (CRF) and persistent growth retardation despite adequate nutritional and metabolic management.The study design included randomized, parallel groups in an open, multicenter trial comparing GH (0.33 mg/kg per wk) with nontreatment with GH during 12 months. Sixteen infants who had growth retardation, were aged 12+/-3 months, had CRF (GFR<or=60 ml/min per 1.73 m2), and had adequate ...
Tópico(s): Neonatal Respiratory Health Research
2010 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Johnson President, Jeremy Rundall, Louis Armstrong, Charles Raw, Richard Buckle, James Margach, Elizabeth Nicholas, Nicholas Carroll Diplomatic Correspondent, Harold Hobson, Henry F. Graff, the Rev G W Butterworth, F L Milman, Ian Peebles, Paul Smith, John Jacobs, Roger Nuttall, A. Shorrocks, Cal McCrystal, Elizabeth Good, Henry Brandon, Lord Hardinge, John Russell, Geoffrey Nicholson, Günter Orlik, A J L Barnes, Philip Clarke, Derek Jewell, Vivian Jenkins, Tom Margerison, Ian Coulter, Peter Willett, David Sylvester, R S Borner Secretary, Robin Marlar, Hugh Somerville, Cyril Connolly, T W Lake, Sir Herbert Thompson, L Frank General Secretary, Raymond Mortimer, Oliver Marriott, Maxwell Boyd, Hugh Cawdron, John Barry, E S Page, Peter Wilsher, Mr. G. E. Liardet's, Susan Noel, Arthur J White, Roger Mortimer, Gill H Bochringer, Brigid Brophy, Ernestine Carter, Tangley's, Desmond Shawe-Taylor, Stephen Coulter, Peter Mansfield, E Hatfield Crowther, H G S Plunkett, Mr. R. F. Hill's, Stephen Aris, Lanning Roper, Dr Fredrick Stare Professor, David Caute, Dilys Powell, Brigid Keenan, Reginald Maudling, Richard Hughes, William Rees-Mogg, Mr. Johnson, Harold Abrahams, Felix Aprahamian, Robert Carrier, Benjamin Pogrund, Ian Coulter Industrial Correspondent, Margaret Drabble, Henry Longhurst, Lewis Chester, Peter Graham, Dr Alfred Byrne Medical Correspondent, A M Large, Adam Frost, Arthur Hopcraft, Michael Moynihan, Brian Glanville, Derek Wilson, Keith Richardson, Benny Green, C. H. O'd. Alexander, Maurice Wiggin, Paul E H Rhodes, Mr. J. R. Locker, D. S. T., Hans Keller, Anthony Cowdy, Kenneth Konstam, John Mattison, Nicholas Tomalin,
... her revenge as the fluent game of Miss Bueno suddenly collapses Now the champion may reign for ... Benz Mercedes-Benz The artist and his model: Alberto and Annette… Giacometti: An Inability to Tinker 'Terylene' ...
1965 - Gale Group | Sunday Times HA GDA
Francisco Fernández‐Avilés, José Alberto San Román, Javier García‐Frade, María Eugenia Fernández‐Santos, María Jesús Peñarrubia, Luis de la Fuente, Manuel Gómez‐Bueno, Alberto María Torre Cantalapiedra, Jesús Fernández, Oliver Gutiérrez, Pedro L. Sánchez, Carolina Hernández, Ricardo Sanz, Javier Garcı́a-Sancho, Ana Sánchez,
Bone marrow mononuclear cells (BMCs) from 20 patients with extensive reperfused myocardial infarction (MI) were used to assess their myocardial regenerative capability “in vitro” and their effect on postinfarction left ventricular (LV) remodeling. Human BMCs were labeled, seeded on top of cryoinjured mice heart slices, and cultured. BMCs showed tropism for and ability to graft into the damaged mouse cardiac tissue and, after 1 week, acquired a cardiomyocyte phenotype and expressed cardiac proteins, ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2004 - Lippincott Williams & Wilkins | Circulation Research
Òscar Miró, Ana García Sarasola, Carolina Fuenzalida, Sofía Calderón, Javier Jacob, Alfons Aguirre, Da M. Wu, Miguel Alberto Rizzi, Pierre Malchair, Antonio Haro, Sergio Herrera, Víctor Gil, Francisco Javier Martín‐Sánchez, Pere Llorens, Pablo Herrero, Héctor Bueno, Alberto Domínguez Rodríguez, Christian Müller, Alexandre Mebazaa, Ovidiu Chioncel, Aitor Alquézar‐Arbé,
Objectives We investigated the natural history of patients after a first episode of acute heart failure (FEAHF) requiring emergency department (ED) consultation, focusing on: the frequency of ED visits and hospitalisations, departments admitting patients during the first and subsequent hospitalisations, and factors associated with difficult disease control. Methods and results We included consecutive patients diagnosed with FEAHF (either with or without previous heart failure diagnosis) in four EDs ...
Tópico(s): Chronic Disease Management Strategies
2019 - Elsevier BV | European Journal of Heart Failure
Sandra L. A. Bueno, Alberto Leonardi, Nabojit Kar, Kaustav Chatterjee, Xun Zhan, Changqiang Chen, Zhiyu Wang, Michael Engel, Victor Fung, Sara E. Skrabalak,
Colloidally prepared core@shell nanoparticles (NPs) were converted to monodisperse high entropy alloy (HEA) NPs by annealing, including quinary, senary, and septenary phases comprised of PdCuPtNi with Co, Ir, Rh, Fe, and/or Ru. Intraparticle heterogeneity, i.e., subdomains within individual NPs with different metal distributions, was observed for NPs containing Ir and Ru, with the phase stabilities of the HEAs studied by atomistic simulations. The quinary HEA NPs were found to be durable catalysts ...
Tópico(s): High-Temperature Coating Behaviors
2022 - American Chemical Society | ACS Nano
Aitor Uribarri, Héctor Bueno, Alberto Pérez‐Castellanos, Gerard Loughlin, Iago Sousa, Ana Viana‐Tejedor, Francisco Fernández‐Avilés,
Little is known about the role of time to initiation of therapeutic hypothermia and time to target temperature (TTT) in the prognosis of patients resuscitated from cardiac arrest.A retrospective analysis was performed in 145 survivors of cardiac arrest who underwent therapeutic hypothermia between January 2003 and January 2013. The objective was to identify predictors of survival free from significant neurological sequelae (Cerebral Performance Categories Scale (CPC): >2) six months after cardiac arrest. ...
Tópico(s): Heart Rate Variability and Autonomic Control
2014 - Oxford University Press | European Heart Journal Acute Cardiovascular Care
José María García Bueno, Alberto Ocaña, Paola Castro‐Garcia, Carmen Gil Gas, Francisco Sánchez‐Sánchez, Enrique Poblet, Rosario Serrano, Raúl Calero, Carmen Ramírez‐Castillejo,
Tópico(s): Cancer-related Molecular Pathways
2008 - Springer Science+Business Media | Clinical & Translational Oncology
Manuel Martínez‐Sellés, Héctor Bueno, Alberto Sacristán, Álvaro G. Estévez, Javier Ortíz, Laura Gallegoa, Francisco Fernández‐Avilés,
El dolor torácico es un síntoma muy frecuente en urgencias, pero su gestión clínica suele ser heterogénea. Nuestro objetivo es caracterizar a los pacientes con dolor torácico y valorar la utilidad en estratificación del índice de riesgo UDT-65, que atribuye un punto a cada una de las siguientes variables: uso de aspirina, diabetes, tipicidad del dolor torácico y 65 o más años de edad. Registro prospectivo de los ingresos por dolor torácico no traumático en el servicio de urgencias. Durante 3 meses, ...
Tópico(s): Acute Myocardial Infarction Research
2008 - Elsevier BV | Revista Española de Cardiología
Manuel Martínez‐Sellés, Héctor Bueno, Alberto Sacristán, Álvaro G. Estévez, Javier Ortíz, Laura Gallego, Francisco Fernández‐Avilés,
Although chest pain is a common presenting symptom in emergency departments, its clinical management is highly variable. Our aims were to describe the characteristics of patients with chest pain and to evaluate the usefulness of the CPU-65 index for risk stratification. The CPU-65 index awards one point for each of the following variables: Comorbid diabetes, typical Pain, Use of aspirin, and age 65 years or more.Details of emergency department patients admitted for nontraumatic chest pain were recorded ...
Tópico(s): Cardiac Imaging and Diagnostics
2008 - Elsevier BV | Revista Española de Cardiología (English Edition)
Eduardo Sandes, Catalina Lodillinsky, Yanina Langle, Denise Belgorosky, Lina Marino, Liliana Giménez, Alberto Ricardo Casabé, Ana María Eiján,
... Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina , Alberto Ricardo CasabéAlberto Ricardo Casabé Surgical Areas, Institute of ... Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina More articles by this author Alberto Ricardo Casabé Surgical Areas, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina More articles by this ...
Tópico(s): Nitric Oxide and Endothelin Effects
2012 - Lippincott Williams & Wilkins | The Journal of Urology
F. Vita Serman, Dilermando Dourado Pacheco, A. Olguín Pringles, L. Ocaña Bueno, Alberto Carelli, F. Capraro,
Tópico(s): Nuts composition and effects
2011 - International Society for Horticultural Science | Acta Horticulturae
Humberto J. Ferreira, Verónica Dávalos, Manuel Castro de Moura, Marta Soler, Montserrat Pérez-Salvia, Alberto Bueno-Costa, Fernando Setién, Sebastián Morán, Alberto Villanueva, Manel Esteller,
Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellular transformation. Work done in the last decade has also demonstrated that ncRNAs with growth-inhibitory functions can undergo promoter CpG island hypermethylation-associated silencing in tumorigenesis. Herein, we wondered whether circular RNAs (circRNAs), a type of RNA transcripts lacking 5'-3' ends and forming closed loops that are gaining relevance in cancer biology, are also a target of epigenetic ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Impact Journals LLC | Oncotarget
Rafael Martínez, Alberto Bueno,
The role of the armed forces in Latin America is characterized by their participation in multiple internal missions. These range from security functions to the provision of social, educational, and public services, among others; their role also involves providing emergency relief. However, some of the armed forces involved in this type of mission do not have specialized units or corps. This poses obvious problems not only from a technical and operational point of view, but also from the perspective ...
Tópico(s): Conflict, Peace, and Violence in Colombia
2023 - SAGE Publishing | Alternatives Global Local Political
Alberto Bueno, Rafael Martínez,
This article responds to the analysis about the Spanish Emergency Military Unit in the research note by Pérez et al. in Armed Forces & Society, which emphasizes the efficiency of the Spanish Emergency Military Unit and how it has enhanced the image of the Spanish Armed Forces. We believe that a more critical understanding of the development of this military unit is necessary, as its deployment pitfalls and the literature on civil–military relations were neglected. Consequently, four policy traps are ...
Tópico(s): Conflict, Peace, and Violence in Colombia
2023 - SAGE Publishing | Armed Forces & Society
Produção Nacional
Revisado por pares
Lícia Mioko Yoshizaki Akinaga, A.J.F.C. Lichtenfels, Regiani Carvalho-Oliveira, Élia Garcia Caldini, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva, Heloisa Maria de Siqueira Bueno, Luiz Alberto Amador Pereira, Paulo Hilário Nascimento Saldiva, Maria Lúcia Bueno Garcia,
To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles <or= 0.3 microm) placed 20 m from a street with heavy traffic in downtown Sao Paulo, twenty-four hours per day for four months. Fine particle (PM(2.5)) concentration was determined gravimetrically; hearts were analyzed by morphometry. There was a reduction of the PM(2.5) inside the filtered chamber ( ...
Tópico(s): Spaceflight effects on biology
2009 - SAGE Publishing | Toxicologic Pathology
Produção Nacional
Revisado por pares
Irismar Reis de Oliveira, Hélio Elkis, Wagner F. Gattaz, Ana Cristina Chaves, Eduardo Pondé de Sena, Fábio Gomes de Matos e Souza, João Alberto de Oliveira Campos, João Romildo Bueno, Jorge Alberto Costa e Silva, Mário R. Louzã, Paulo Belmonte‐de‐Abreu,
Introduction : Aripiprazole, a dopamine D 2 receptor partial agonist, has also partial agonist activity at serotonin (5-HT) 1A receptors and antagonist activity at 5-HT 2A receptors. Methods : In this 8-week, multicenter, randomized, parallel-group, open-label, flexible-dose study, patients diagnosed with schizophrenia or schizoaffective disorder were randomized to aripiprazole 15–30 mg/day or haloperidol 10–15 mg/day. Results : Patients treated with both aripiprazole and haloperidol improved from baseline ...
Tópico(s): Bipolar Disorder and Treatment
2009 - Cambridge University Press | CNS Spectrums
Maxime Janin, Vanessa Ortiz-Barahona, Manuel Castro de Moura, Anna Martínez‐Cardús, Pere Llinàs‐Arias, Marta Soler, Daphna Nachmani, Joffrey Pelletier, Ulrike Schümann, María Eréndira Calleja-Cervantes, Sebastián Morán, Sònia Guil, Alberto Bueno-Costa, David Piñeyro, Montserrat Pérez-Salvia, Margalida Rosselló-Tortella, Laia Piqué, Joan Josep Bech‐Serra, Carolina de la Torre, August Vidal, María Martínez‐Iniesta, Juan F. Martín-Tejera, Alberto Villanueva, Alexandra Arias, Isabel Cuartas, Ana M. Aransay, Andrés Morales La Madrid, Ángel M. Carcaboso, Vicente Santa‐María, Jaume Mora, Agustín F. Fernández, Mario F. Fraga, Ibán Aldecoa, Leire Pedrosa, Francesc Graus, Noemí Vidal, Fina Martínez‐Soler, Avelina Tortosa, Cristina Carrato, Carmen Balañá, Matthew W. Boudreau, Paul J. Hergenrother, Peter Kötter, Karl-Dieter Entian, Jürgen Hench, Stephan Frank, Sheila Mansouri, Gelareh Zadeh, Pablo D. Dans, Modesto Orozco, George Thomas, Sandra Blanco, Joan Seoane, Thomas Preiß, Pier Paolo Pandolfi, Manel Esteller,
Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-called epitranscriptome. Here, we report that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine. In this setting, NSUN5 exhibits tumor-suppressor characteristics in vivo glioma models. We also found that NSUN5 ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Springer Science+Business Media | Acta Neuropathologica
Jeroni Morey, Pere Llinàs‐Arias, Alberto Bueno-Costa, Alberto J. León, María de las Nieves Piña,
Two different raltitrexed gold and silver nanoparticles for the delivery of an antitumoral drug into cancer cells were synthesized and characterized. A cysteine linker was used for the covalent bonding of raltitrexed to the surface of nanoparticles. To evaluate the efficacy of the antifolate-derivative nanoparticles, their cytotoxicity was assayed in vitro with A549 human lung adenocarcinoma and HCT-116 colorectal carcinoma human cells. Modified nanoparticles are a biocompatible material, and administration ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2021 - Multidisciplinary Digital Publishing Institute | Materials
Valeria de Miguel, Aníbal Arias, Andrea Paissan, Diego Pérez de Arenaza, Marcelo Pietrani, Alberto Jurado, Ana Jaén, Patricia Day,
... A. Jaén) Units, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , Alberto JuradoAlberto Jurado From the Endocrinology (V.d.M., A.P., P.F.D.), Cardiology (A.A., D.P.d.A.), Radiology (M.P.), Urology (A.Jurado), and Pathology (A. Jaén) Units, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. , Ana JaénAna Jaén From ...
Tópico(s): Drug-Induced Ocular Toxicity
2014 - Lippincott Williams & Wilkins | Circulation
Marta Casado-Peláez, Alberto Bueno-Costa, Manel Esteller,
The epigenome encompasses several mechanisms controlling gene expression that can be aberrantly regulated during cancer development and progression. Tumors are highly complex and heterogeneous biological systems that require the study of epigenetic alterations at a single cell resolution.Several single cell technologies developed to study different layers of the epigenome, such as chromatin accessibility or histone modifications, have been developed and applied in cancer research over the past few ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Elsevier BV | Trends in cancer
José Felipe Orzuna‐Orzuna, Griselda Dorantes-Iturbide, Alejandro Lara-Bueno, Luis Alberto Miranda‐Romero, Germán David Mendoza Martínez, Itzel Santiago-Figueroa,
The objective of this study was to see how dietary supplementation with essential oils (EOs) affected rumen fermentation, blood metabolites, growth performance and meat quality of beef cattle through a meta-analysis. In addition, a simulation analysis was conducted to evaluate the effects of EOs on the economic and environmental impact of beef production. Data were extracted from 34 peer-reviewed studies and analyzed using random-effects statistical models to assess the weighted mean difference (WMD) ...
Tópico(s): Rabbits: Nutrition, Reproduction, Health
2022 - Multidisciplinary Digital Publishing Institute | Fermentation
Lucas B. Pontel, Alberto Bueno-Costa, Agustín E. Morellato, Juliana C. Santos, Gaël Roué, Manel Esteller,
Ferroptosis is a form of cell death triggered by phospholipid hydroperoxides (PLOOH) generated from the iron-dependent oxidation of polyunsaturated fatty acids (PUFAs). To prevent ferroptosis, cells rely on the antioxidant glutathione (GSH), which serves as cofactor of the glutathione peroxidase 4 (GPX4) for the neutralization of PLOOHs. Some cancer cells can also limit ferroptosis through a GSH-independent axis, centered mainly on the ferroptosis suppressor protein 1 (FSP1). The significance of these ...
Tópico(s): RNA modifications and cancer
2022 - Elsevier BV | Redox Biology
Carlos A. García‐Prieto, Damiana Álvarez‐Errico, Eva Musulén, Alberto Bueno-Costa, Berta N. Vázquez, Alejandro Vaquero, Manel Esteller,
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. However, much less is known about the mouse epigenome, particularly for DNA methylation. Progress in delivering mouse DNA methylomes has been slow due to the currently available time-consuming and expensive methodologies. Following the great acceptance of the human DNA ...
Tópico(s): Genetic Syndromes and Imprinting
2022 - Landes Bioscience | Epigenetics
Vicente Martínez‐Vizcaíno, Gema Sanabria‐Martínez, Rubén Fernández‐Rodríguez, Iván Cavero‐Redondo, Carlos Pascual‐Morena, Celia Álvarez‐Bueno, José Alberto Martínez‐Hortelano,
This study aimed to provide, through an umbrella review, an overview of the effect of single exercise interventions during pregnancy on gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Also, to update the current evidence through an updated meta-analysis.
Tópico(s): Pregnancy and preeclampsia studies
2022 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
Carlos A. García‐Prieto, Lorea Villanueva, Alberto Bueno-Costa, Verónica Dávalos, Azucena González-Navarro, Manel Juan, Álvaro Urbano‐Ispizua, Julio Delgado, Valentín Ortiz‐Maldonado, Francesca Del Bufalo, Franco Locatelli, Concetta Quintarelli, Matilde Sinibaldi, Marta Soler, Manuel Castro de Moura, Gerardo Ferrer, Rocío G. Urdinguio, Agustín F. Fernández, Mario F. Fraga, Diana Bar, Amilia Meir, Orit Itzhaki, Michal J. Besser, Abraham Avigdor, Elad Jacoby, Manel Esteller,
Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. The increasingly recognized relevance of epigenetic changes in cancer immunology prompted us to determine the impact of the DNA methylation profiles of CART19 cells on the clinical course.We recruited 114 patients with B-cell malignancies, comprising 77 patients with acute lymphoblastic leukemia and ...
Tópico(s): CAR-T cell therapy research
2021 - Oxford University Press | JNCI Journal of the National Cancer Institute
Rosaura Esteve‐Puig, Alberto Bueno-Costa, Manel Esteller,
Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone modifications. Very recently, a third component has emerged: the so-called epitranscriptome understood as the chemical modifications of RNA that regulate and alter the activity of RNA molecules. In this regard, the study of genetic and epigenetic disruption ...
Tópico(s): Cancer-related gene regulation
2020 - Elsevier BV | Cancer Letters
Produção Nacional
Revisado por pares
Ana Luiza Mendonça Gomes, Antônio Vinícius Iank Bueno, Fernando Alberto Jacovaci, Guilherme Donadel, L.F. Ferraretto, Luiz Gustavo Nussio, Clóves Cabreira Jobim, João Luiz Pratti Daniel,
Abstract Our objective was to examine the effects of processing, moisture, and anaerobic storage length of reconstituted corn grain (RCG) on the fermentation profile, geometric mean particle size (GMPS), and ruminal dry matter disappearance (DMD). Dry corn kernels were ground (hammer mill, 5-mm screen) or rolled, then rehydrated to 30%, 35%, or 40% moisture, and stored for 0, 14, 30, 60, 90, 120, or 180 d in laboratory silos. Rolled corn had an increased GMPS compared with ground corn (2.24 and 1.13 ...
Tópico(s): Food Security and Health in Diverse Populations
2020 - Oxford University Press | Journal of Animal Science