José Calderón-Infante, Alberto Castellano, Álvaro Herráez, Luis E. Ibáñez,
The Swampland Distance Conjecture (SDC) states that, as we move towards an infinite distance point in moduli space, a tower of states becomes exponentially light with the geodesic distance in any consistent theory of Quantum Gravity. Although this fact has been tested in large sets of examples, it is fair to say that a bottom-up justification that explains both the geodesic requirement and the exponential behavior has been missing so far. In the present paper we address this issue by making use of ...
Tópico(s): Homotopy and Cohomology in Algebraic Topology
2024 - Springer Nature | Journal of High Energy Physics
Alberto Castellano, Ignacio Ruiz, Irene Valenzuela,
Quantum gravitational effects become significant at a cutoff that can be much lower than the Planck scale whenever there is a large number of light fields. This is expected to occur at any perturbative limit of an effective field theory coupled to gravity, or equivalently, at infinite distance in the field space of the UV completion. In this note, we present a universal pattern that links the asymptotic variation in field space of the quantum gravity cutoff Λ_{sp} and the characteristic mass of ...
Tópico(s): Noncommutative and Quantum Gravity Theories
2024 - American Physical Society | Physical Review Letters
Alberto Castellano, Ignacio Ruiz, Irene Valenzuela,
A bstract Infinite distance limits in the moduli space of a quantum gravity theory are characterized by having infinite towers of states becoming light, as dictated by the Distance Conjecture in the Swampland program. These towers imply a drastic breakdown in the perturbative regimes of the effective field theory at a quantum gravity cut-off scale known as the species scale. In this work, we find a universal pattern satisfied in all known infinite distance limits of string theory compactifications, ...
Tópico(s): Cosmology and Gravitation Theories
2024 - Springer Nature | Journal of High Energy Physics
Produção Nacional
Revisado por pares
Décio Mion, Marco Antônio Mota Gomes, Fernando Nobre, Celso Amodeo, Osvaldo Kohlmann, José Nery Praxedes, Carlos Alberto Castellanos Machado, Carlos Alberto Castellanos Machado, I. Pascoal, Lucélia C. Magalhães,
controle em todo o país.
Tópico(s): Blood Pressure and Hypertension Studies
2004 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Jip W T M de Kok, Miguel Ángel Armengol de la Hoz, Y. de Jong, Véronique Brokke, Paul Elbers, Patrick Thoral, Alejandro Castillejo, Tomás Trenor, José María Castellano, Alberto E. Bronchalo, Tobias M. Merz, Martin Faltys, Cristina Casares, Araceli Jiménez, Jaime Requejo, Sonia Gutiérrez, David Curto, Gunnar Rätsch, Jan M. Peppink, Ronald H. Driessen, Eric J.G. Sijbrands, Erwin J. O. Kompanje, Armand R. J. Girbes, José Barberán, José F. Varona, Paula Villares, Iwan C.C. van der Horst, Minnan Xu, Leo Anthony Celi, Bas C. T. van Bussel, X. Borrat,
Sharing healthcare data is increasingly essential for developing data-driven improvements in patient care at the Intensive Care Unit (ICU). However, it is also very challenging under the strict privacy legislation of the European Union (EU). Therefore, we explored four successful open ICU healthcare databases to determine how open healthcare data can be shared appropriately in the EU. A questionnaire was constructed based on the Delphi method. Then, follow-up questions were discussed with experts ...
Tópico(s): Electronic Health Records Systems
2023 - Nature Portfolio | Scientific Data
Ilenia Pirola, Elena Gandossi, Mario Rotondi, Fiorella Marini, Alessandra Cristiano, Luca Chiovato, Maurizio Castellano, Alberto Ferlin, Carlo Cappelli,
Abstract Purpose To evaluate the possible association between Covid-19 infection and subacute thyroiditis. Methods We reviewed the medical and imaging records of patients referred to our Department’s outpatient setting dedicated to ‘thyroid emergency’ (records with a ‘ bollino verde ’—green sticker, classifed as urgent) from April 2020 to October 2020. This outpatient clinic is devoted to patients requiring evaluation for severe hypothyroidism, thyrotoxicosis and neck discomfort or pain. All patients ...
Tópico(s): Biomarkers in Disease Mechanisms
2021 - Springer Science+Business Media | Endocrine
Elvira L. Vos, Masaya Nakauchi, Mithat Gönen, Jason Castellanos, Alberto Biondi, Daniel G. Coit, Johan L. Dikken, Domenico D’Ugo, Henk H. Hartgrink, Ping Li, Makoto Nishimura, Mark Schattner, Kyo Young Song, Laura H. Tang, Ichiro Uyama, Santosha A. Vardhana, Rob H.A. Verhoeven, Bas P. L. Wijnhoven, Vivian E. Strong,
We sought to define criteria associated with low lymph node metastasis risk in patients with submucosal (pT1b) gastric cancer from 3 Western and 3 Eastern countries.
Tópico(s): Gastrointestinal Tumor Research and Treatment
2021 - Lippincott Williams & Wilkins | Annals of Surgery
Javier Bayo, Sonia Olmos, Joaquín López‐Castellanos, Alberto Alcolea,
The presence of microplastics and synthetic microfibers in the environment is increasing, causing an accumulation in the food chain because their ingestion by different organisms in the ecological community.This paper deals with the importance of wastewater treatment plants (WWTPs) as a source of microplastics and microfibers from the sludge to the environment.These micropollutants have been monitored in an urban WWTP during 2015, after being separated from the sludge.Micropollutants were extracted ...
Tópico(s): Recycling and Waste Management Techniques
2016 - International Information and Engineering Technology Association | International Journal of Sustainable Development and Planning
Óscar Jiménez-Castellanos, Alberto M. Ochoa, Edward M. Olivos,
The article examines a model for transformative parent engagement in predominantly Latino and ethnically diverse school communities. A case study illustrates the initial phases of the five-level process and the challenges of actualizing the parent engagement process. The author's challenge commonly accepted boundaries of bicultural parent involvement. A case study provides a real-life example of a large urban school district that has introduced community school-based reform to create and apply the ...
Tópico(s): Early Childhood Education and Development
2016 - | Journal of Latino/Latin American Studies
MARCO ANTONIO RODRÍGUEZ-CASTELLANOS, Alberto Tlacuilo‐Parra, Sergio Sánchez‐Enríquez, Ezequiel Vélez-Gómez, Elizabeth Guevara‐Gutiérrez,
Localized scleroderma is an inflammatory disease in its first stages and a fibrotic process in later stages, principally mediated by the transforming growth factor β. To date, there is no standard treatment. The objective of this study was to determine the effectiveness and safety of 8% pirfenidone gel in patients with localized scleroderma.This was an open phase II clinical trial that included 12 patients. Treatment with pirfenidone was indicated, three times daily for 6 months. Patients were evaluated ...
Tópico(s): Mast cells and histamine
2014 - BioMed Central | Arthritis Research & Therapy
Edward M. Olivos, Óscar Jiménez-Castellanos, Alberto M. Ochoa,
This book examines how commonly applied approaches to parent involvement in schools do not easily transfer to bilingual and bicultural families. The authors--respected scholars in the field of educational equity--challenge commonly accepted boundaries of bicultural parent involvement. They provide real-life examples, practical strategies, discussion questions, and suggestions for ensuring that schools welcome and value bicultural families. This timely resource is a hopeful vision of what authentic ...
Tópico(s): Parental Involvement in Education
2012 - Association of College and Research Libraries | Choice Reviews Online
Miguel Fernández-Tenorio, Cristina Porras‐González, Antonio Castellano, Alberto del Valle-Rodríguez, José López‐Barneo, Juán Ureña,
Background: Sustained vascular smooth muscle contraction is mediated by extracellular Ca 2+ influx through L-type voltage-gated Ca 2+ channels (VGCC) and RhoA/Rho-associated kinase (ROCK)-dependent Ca 2+ sensitization of the contractile machinery. VGCC activation can also trigger an ion-independent metabotropic pathway that involves G-protein/phospholipase C activation, inositol 1,4,5-trisphosphate synthesis, and Ca 2+ release from the sarcoplasmic reticulum (calcium channel-induced Ca 2+ release). ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2011 - Lippincott Williams & Wilkins | Circulation Research
... Governance Perspective on Emerging Systemic Risks Giuliano G. Castellano Epilogue Alberto Alemanno Index
Tópico(s): Disaster Management and Resilience
2011 - RELX Group (Netherlands) | SSRN Electronic Journal
Ileana Bortolomai, Silvana Canevari, Ileana Facetti, Loris De Cecco, Giancarlo Castellano, Alberto Zacchetti, Malcolm Alison, Silvia Miotti,
To investigate the tumor fraction with cancer stem/tumor initiating cell (CSC/TIC) characteristics, we tested the human cervical carcinoma cell lines A431, Caski and SiHa, by growth as non-adherent spheres in specific media and aldehyde dehydrogenase (ALDH) enzymatic activity. A good correlation between the two parameters was observed and the highest levels were observed in A431 cell line that was selected for characterization of the CSC/TIC fraction. A431 parental cells already displayed characteristics ...
Tópico(s): 3D Printing in Biomedical Research
2010 - Taylor & Francis | Cell Cycle
Maria Rosaria Plutino, Lucia Fenech, Sergio Stoccoro, S. Rizzato, Carlo Castellano, Alberto Albinati,
Cationic ethylene platinum(II) complexes of the type [Pt(CNN)(C2H4)]+, containing a methyl fragment and different diimines (NN), or terdentate (κC-κ2NN′) anionic ligands, were synthesized and fully characterized both as solids and in solution [NN = 2,2′-dipyridylamine, 1; 2,2′-dipyridylsulfide, 2; 1,10-phenanthroline, 3; 4,7-diphenyl-1,10-phenanthroline, 4; 3,4,7,8-tetramethyl-1,10-phenanthroline, 5; 2,2′-bipyridine, 6; HC-NN = 6-tert-butyl-2,2′-bipyridine, 7; 6-neo-pentyl-2,2′-bipyridine, 8; 6-phenyl-2, ...
Tópico(s): Radioactive element chemistry and processing
2009 - American Chemical Society | Inorganic Chemistry
Francesca Managò, Claudio Castellano, Alberto Oliverio, Andrea Mele, Elvira De Leonibus,
Recent evidence demonstrated that dopamine within the nucleus accumbens mediates consolidation of both associative and nonassociative memories. However, the specific contribution of the nucleus accumbens subregions, core and shell, and of D1 and D2 receptors subtypes has not been yet clarified. The aim of this study was, therefore, to directly compare the effect of D1 and D2 dopamine receptor blockade within the core and the shell subregions of the nucleus accumbens on memory consolidation. Using ...
Tópico(s): Memory and Neural Mechanisms
2008 - Cold Spring Harbor Laboratory Press | Learning & Memory
Carole Berruyer-Pouyet, Florent Martin, Rémy Castellano, Alberto Macone, Fabrice Malergue, Sarah Garrido‐Urbani, Virginie Millet, Jean Imbert, Silvestro Duprè, Giuseppina Pitari, Philippe Naquet, Franck Galland,
Vanin-1 is an epithelial ectoenzyme with pantetheinase activity and generating the amino-thiol cysteamine through the metabolism of pantothenic acid (vitamin B(5)). Here we show that Vanin-1(-/-) mice, which lack cysteamine in tissues, exhibit resistance to oxidative injury induced by whole-body gamma-irradiation or paraquat. This protection is correlated with reduced apoptosis and inflammation and is reversed by treating mutant animals with cystamine. The better tolerance of the Vanin-1(-/-) mice ...
Tópico(s): Porphyrin Metabolism and Disorders
2004 - Taylor & Francis | Molecular and Cellular Biology
Guido Caldarelli, Claudio Castellano, Alberto Petri,
Abstract In this paper we investigate the influence of different boundary conditions on the final breakdown of a lattice model for the fracture of heterogeneous media. Experimental evidence shows that disordered media subject to stress display some features that are characteristic of critical systems, therefore suggesting an interpretation of the global breakdown of the system as a kind of critical transition. Many of the observed features are well reproduced at least at a qualitative level by lattice ...
Tópico(s): Landslides and related hazards
1999 - Taylor & Francis | Philosophical Magazine B
Guido Caldarelli, Claudio Castellano, Alberto Petri,
It has been recently noticed that heterogeneous media undergoing a fracturing process display a set of properties characteristic of systems at the critical state. In the present work we focus on the way in which the critical regime is reached. It is possible to define a branching ratio, for the breaking processses in the material, that represents the probability to trigger future breakdowns given an initial failure. This probability takes the value 1 when the system is critical thereby representing ...
Tópico(s): Advanced Mathematical Modeling in Engineering
1999 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Andrea Basile, Antonio Sica, Elisabetta d’Aniello, Ferruccio Breviario, Gabino Garrido, Marina Castellano, Alberto Mantovani, Martino Introna,
The "long pentraxins" are an emerging family of genes that have conserved in their carboxy-terminal halves a pentraxin domain homologous to the prototypical acute phase protein pentraxins (C-reactive protein and serum amyloid P component) and acquired novel amino-terminal domains. In this report, a genomic fragment of 1371 nucleotides from the human "long pentraxin" gene PTX3 is characterized as a promoter on tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta exposure in transfected 8387 ...
Tópico(s): Circular RNAs in diseases
1997 - Elsevier BV | Journal of Biological Chemistry
Agustín Castellanos, Alberto Interian, Marilyn M. Cox, Robert J. Myerburg,
Alternating Wenckebach periods (AWPs) are episodes of 2:1 block during which the PR, AH, or AV intervals of the conducted beats gradually increase until a greater degree of block ensues. Most episodes occur at the AV node, but some have also been reported in other structures. AWPs are usually attributed to multilevel block due to transverse (horizontal) dissociation. This assumption was initially based on a method in which the solutions to difficult electrocardiographic rhythms were arrived at by ...
Tópico(s): Atrial Fibrillation Management and Outcomes
1993 - Wiley | Pacing and Clinical Electrophysiology
Stefano Puglisi‐Allegra, Claudio Castellano, Alberto Oliverio,
Stress-induced analgesia, assessed in two strains of mice (C57BL/6 and SEC/1Re), presents daily or circadian variations which are related to fluctuations in the release of endogenous opioids. These fluctuations may account for differences in individual reactivity to stressful events during 24 h.
Tópico(s): Stress Responses and Cortisol
1982 - Elsevier BV | Brain Research
Umberto Filibeck, Claudio Castellano, Alberto Oliverio,
Tópico(s): Receptor Mechanisms and Signaling
1981 - Springer Science+Business Media | Psychopharmacology
Enrico Alleva, Claudio Castellano, Alberto Oliverio,
Among inbred mouse strains, DBA/2 mice are unique because of their poor responsiveness to nitrous oxide (N2O) antinociception. As a first step towards identifying candidate genes involved in determining antinociceptive responsiveness to N2O, male mice from the DBA/2 strain, the more responsive C57BL/6 strain, their B6D2F1 offspring, and 22 BXD recombinant inbred (RI) strains derived from DBA/2 and C57BL/6 mice were exposed to N20 and evaluated using the acetic acid abdominal constriction test. When ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1980 - Elsevier BV | Brain Research
Claudio Castellano, Alberto Oliverio,
The effects of early undernutrition were studied by rearing mice in small, intermediate or large litters (respectively 4, 8 or 16 pups). Measures of reflexes and electrocorticographic activity applied from birth to weaning indicated that malnutrition resulted in a clear ontogenetic retardation which was followed by permanent body and brain stunting. The mice from the large litters were characterized by increased exploratory activity and by lower avoidance learning ability as measured 45 days after ...
Tópico(s): Child Nutrition and Water Access
1976 - Elsevier BV | Brain Research
Claudio Castellano, Alberto Oliverio,
Tópico(s): Neuroendocrine regulation and behavior
1975 - Springer Science+Business Media | Psychopharmacology
Produção Nacional
Revisado por pares
Mauricio Barrios Castellanos, Alberto Luiz Serpa, Jorge Luiz Biazussi, William Monte Verde, Natache do Socorro Dias Arrifano Sassim,
The monitoring of centrifugal pumps is essential for the suitable operation of several industrial applications. The reliability of petroleum artificial lifting systems that use Electrical Submersible Pumps (ESP) depends substantially on the performance of these pumps. ESP can operate subjected to severe operating conditions such as viscous and two-phase flow. In recent years, real-time technologies based on machine learning algorithms have gained importance due to the capability to take advantage ...
Tópico(s): Machine Fault Diagnosis Techniques
2019 - Elsevier BV | Journal of Petroleum Science and Engineering
Loredana Amoroso, Marzia Ognibene, Martina Morini, Massimo Conte, Andrea Di Cataldo, Annalisa Tondo, Paolo D’Angelo, Aurora Castellano, Alberto Garaventa, Vito Alessandro Lasorsa, Marina Podestà, Mario Capasso, Annalisa Pezzolo,
Neuroblastoma (NB) is the most common extracranial malignant tumor of childhood and is characterized by a broad heterogeneity in clinical presentation and evolution. Recent advances in pangenomic analysis of NB have revealed different recurrent chromosomal aberrations. Indeed, it is now well established that the overall genomic profile is important for treatment stratification. In previous studies, 11 genes were shown to be recurrently amplified (ODC1, ALK, GREB1, NTSR2, LIN28B, MDM2, CDK4, MYEOV, ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Wiley | Genes Chromosomes and Cancer
Sandro Fagioli, Claudio Castellano, Alberto Oliverio, G. Toffano,
Chronic administration of GM1 ganglioside to C57BL/6 mice during development improved passive avoidance retention. A significant weight increase was also evident in the treated animals in comparison with the control group. The results are discussed in terms of the possible effects exerted by GM1 upon the cholinergic mechanisms of this inbred strain.
Tópico(s): ATP Synthase and ATPases Research
1990 - Elsevier BV | Neuroscience Letters
Umberto Filibeck, Claudio Castellano, Alberto Oliverio,
The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems responsible for the non-analgesic effects of morphine are not characterized by the same developmental pattern.
Tópico(s): Receptor Mechanisms and Signaling
1981 - Elsevier BV | Developmental Brain Research