Gaetana Costanza, Elena Doldo, Amedeo Ferlosio, Chiara Tarquini, Daniela Passeri, Raffaella Cascella, Mauro Bavetta, Alessandro Di Stefani, Claudio Bonifati, Sara Agostinelli, Federica Centofanti, Emiliano Giardina, Elena Campione, Luca Bianchi, Pietro Donati, Aldo Morrone, Augusto Orlandi,
... 2 , Elena Campione 3 , Luca Bianchi 3 , Pietro Donati 4 , Aldo Morrone 4 and Augusto Orlandi 1, 5 1 ...
Tópico(s): Acne and Rosacea Treatments and Effects
2018 - Impact Journals LLC | Oncotarget
Karen Roberts, Antonella Ursini, Robert J. Barnaby, Paolo G. Cassarà, Mauro Corsi, Giovanni Curotto, Daniele Donati, Aldo Feriani, Gabriella Finizia, Carla Marchioro, Daniela Niccolai, Beatrice Oliosi, Stefano Polinelli, Emiliangelo Ratti, Angelo Reggiani, Giovanna Tedesco, Maria Elvira Tranquillini, David G. Trist, Franciscus T. M. van Amsterdam,
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry
Fabrizio Micheli, Romano Di Fabio, Roberto Benedetti, Anna Maria Capelli, Palmina Cavallini, Paolo Cavanni, Silvia Davalli, Daniele Donati, Aldo Feriani, Sylvie Géhanne, Mahmoud Hamdan, Micaela Maffeis, Fabio Maria Sabbatini, Maria Elvira Tranquillini, Monica Viziano,
Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester, a potent and selective mGluR1 non-competitive antagonist, we report here a detailed exploration of the C-2 position of this scaffold with the preparation of differently substituted amides. Great improvement of the pharmacokinetic properties has been achieved through this exercise.
Tópico(s): Ion channel regulation and function
2004 - Elsevier BV | Il Farmaco
Fabrizio Micheli, Romano Di Fabio, Paolo Cavanni, Joseph M. Rimland, Anna Maria Capelli, Cristiano Chiamulera, Mauro Corsi, Corrado Corti, Daniele Donati, Aldo Feriani, Francesco Ferraguti, Micaela Maffeis, Andrea Missio, Emiliangelo Ratti, Alfredo Paio, Roberta Pachera, M. Quartaroli, Angelo Reggiani, Fabio Maria Sabbatini, David G. Trist, Annarosa Ugolini, Giovanni Vitulli,
Tópico(s): Photochromic and Fluorescence Chemistry
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
Antonella Ursini, Anna Maria Capelli, Robin A. E. Carr, Paolo G. Cassarà, Mauro Corsi, Ornella Curcuruto, Giovanni Curotto, Michele Dal Cin, Silvia Davalli, Daniele Donati, Aldo Feriani, Harry Finch, Gabriella Finizia, G. Gaviraghi, Marc Marien, Giorgio Pentassuglia, Stefano Polinelli, Emiliangelo Ratti, Aldo Reggiani, Giorgio Tarzia, Giovanna Tedesco, Maria Elvira Tranquillini, David G. Trist, F. Th. M. van Amsterdam,
A series of 5-phenyl-3-ureidobenzodiazepine-2,4-diones was synthesized and evaluated as cholecystokinin-B (CCK-B) receptor antagonists. Structure-activity relationship (SAR) studies revealed the importance of the N-1 substituent for potent and selective CCK-B affinity. Addition of substituents at the urea side chain provided in some cases more potent compounds. Moreover the introduction of bulky substituents such as adamantylmethyl at N-1 and resolution of the racemic ureas resulted in our lead compound ...
Tópico(s): Pharmacological Effects of Natural Compounds
2000 - American Chemical Society | Journal of Medicinal Chemistry
Romano Di Fabio, Anna Maria Capelli, Nadia Conti, Alfredo Cugola, Daniele Donati, Aldo Feriani, Paola Gastaldi, G. Gaviraghi, Cheryl T. Hewkin, Fabrizio Micheli, Andrea Missio, Manolo Mugnaini, Angelo Pecunioso, Anna M. Quaglia, Emiliangelo Ratti, Luciana Rossi, Giovanna Tedesco, David G. Trist, Angelo Reggiani,
A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions induced by N-methyl-D-aspartate (NMDA) in mice. 3-[2-[(Phenylamino)carbonyl]ethenyl]-4,6-dichloroindole-2-carboxyl ic acid (8) was an antagonist at the strychnine-insensitive glycine binding site (noncompetitive inhibition of the binding of [3H]TCP, pA2 = 8.1) displaying ...
Tópico(s): Receptor Mechanisms and Signaling
1997 - American Chemical Society | Journal of Medicinal Chemistry
Diana Boraschi, Stefano Censini, M Bartalini, G. Scapigliati, G. Barbarulli, Elisa Vicenzi, Maria Benedetta Donati, Aldo Tagliabue,
Mouse resident peritoneal M phi produced considerable amounts of PGE when triggered in vitro with soluble or particulate stimuli. Preexposure of M phi to IFN-beta dramatically decreased PGE production. This effect depended on the dose of IFN-beta used and was abolished by anti-IFN-beta globulin. In addition to PGE, other AA metabolites of the cyclooxygenase pathway, namely TXB2 and 6-keto PGF1 alpha, were decreased in IFN-beta-treated M phi. However, IFN-beta did not have any effect on cyclooxygenase ...
Tópico(s): Vitamin K Research Studies
1984 - American Association of Immunologists | The Journal of Immunology
Antonella Ursini, Anna Maria Capelli, Robin A. E. Carr, Paolo G. Cassarà, Mauro Corsi, Ornella Curcuruto, Giovanni Curotto, Michele Dal Cin, Silvia Davalli, Daniele Donati, Aldo Feriani, Harry Finch, Gabriella Finizia, G. Gaviraghi, Marc Marien, Giorgio Pentassuglia, Stefano Polinelli, Emiliangelo Ratti, Reggiani, Giorgio Tarzia, Giovanna Tedesco, Maria Elvira Tranquillini, David G. Trist, F. Th. M. van Amsterdam,
... Giovanni Curotto, Michele Dal Cin, Silvia Davalli, Daniele Donati, Aldo Feriani, Harry Finch, Gabriella Finizia, Giovanni Gaviraghi, Marc ...
Tópico(s): Cancer therapeutics and mechanisms
2000 - American Chemical Society | Journal of Medicinal Chemistry
Matteo Nanni, Fabrizio Perna, Carlotta Calamelli, Davide María Donati, Ornella Ferrara, Aldo Parlato, Michele D’Arienzo, Cesare Faldini,
Tópico(s): Total Knee Arthroplasty Outcomes
2013 - Springer Science+Business Media | MUSCULOSKELETAL SURGERY
Maria Mariano, Pietro Donati, Norma Cameli, Flavia Pigliacelli, Aldo Morrone, Antonio Cristaudo,
Ribociclib is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor that has been approved in combination with endocrine therapy for the treatment of hormone receptor-positive/human epidermal growth factor 2-negative advanced or metastatic breast cancer. The main dermatological adverse events associated with CDK 4/6 inhibitors that are described in the literature include skin rash, an increased risk of alopecia, and stomatitis. Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, ...
Tópico(s): Cancer-related Molecular Pathways
2020 - | Journal of Breast Cancer
Romano Di Fabio, Yves St‐Denis, Fabio Maria Sabbatini, Daniele Andreotti, Roberto Arban, Giovanni Bernasconi, Simone Braggio, Frank E. Blaney, Anna Maria Capelli, Emiliano Castiglioni, Enza Di Modugno, Daniele Donati, Elettra Fazzolari, Emiliangelo Ratti, Aldo Feriani, Stefania Contini, Gabriella Gentile, Damiano Ghirlanda, Stefano Provera, Carla Marchioro, Karen Roberts, Anna Mingardi, M. Mattioli, Arnaldo Nalin, Francesca Pavone, Simone Spada, David G. Trist, Angela Worby,
To identify new CRF(1) receptor antagonists, an attempt to modify the bis-heterocycle moiety present in the top region of the dihydropyrrole[2,3]pyridine template was made following new pharmacophoric hypothesis on the CRF(1) receptor antagonists binding pocket. In particular, the 2-thiazole ring, present in the previous series of compounds, was replaced by more hydrophilic non aromatic heterocycles able to make appropriate H-bond interactions with amino acid residues Thr192 and Tyr195. This exploration, ...
Tópico(s): Hormonal Regulation and Hypertension
2008 - American Chemical Society | Journal of Medicinal Chemistry
Susanna Stea, M. Visentin, Donatella Granchi, G. Ciapetti, Maria Benedetta Donati, A Sudanese, Carlo Zanotti, Aldo Toni,
The aim of this work is to assess the correlation between the osteolysis around the prosthesis and the presence of cytokines favouring inflammation in the tissues at the interface between loosened prosthesis and bone. In this study, twenty-nine patients that underwent revision surgery were examined. Bioptic samples were collected at the interface between bone and implant both at the stem and socket level. Semiquantitative immunohistochemistry was performed to detect interleukin 1 alpha, interleukin ...
Tópico(s): Orthopedic Infections and Treatments
2000 - Elsevier BV | Cytokine
L. Savarino, E. Cenni, Susanna Stea, Maria Benedetta Donati, Guglielmo Paganetto, Antonio Moroni, Aldo Toni, A. Pizzoferrato,
The study was focused on the bone tissue response to two types of ceramic coating [alumina and hydroxyapatite (HA)] obtained with a plasma-spray technique. The HA coating was performed on titanium stems, while the alumina coating was on chromium-cobalt-molybdenum stems. The investigation was carried out by means of micro-area X-ray diffractometric analyses and microdiffractometric analyses at the bone-implant interface. Moreover, the coating before and after implantation was analysed by means of the ...
Tópico(s): Advanced materials and composites
1993 - Elsevier BV | Biomaterials
Rosario Casalone, P. Granata Casalone, E. Minelli, P. Portentoso, R. Righi, E. Meroni, A. Giudici, D Donati, Cristina Riva, S. Salvatore, Aldo Bono,
Tópico(s): Urological Disorders and Treatments
1992 - Springer Science+Business Media | Human Genetics
Laura Settimi, Angela Spinelli, Laura Lauria, Giuseppe Miceli, Nicoletta Pupp, G Angotzi, Aldo Fedi, Serena Donati, Lucia Miligi, John Osborn, I Figá-Talamanca,
Abstract Background A positive association between maternal occupational exposure to pesticide and spontaneous abortion has been reported in some studies. Work in greenhouses may imply exposure of pregnant women to pesticides continuously and at elevated level. Methods A total of 717 women working in greenhouses provided information on 973 pregnancies, including 110 spontaneous abortions. These pregnancies were classified as exposed or not exposed according to maternal occupation, re‐entry activities ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2008 - Wiley | American Journal of Industrial Medicine
Romano Di Fabio, Fabrizio Micheli, Davide Baraldi, Barbara Bertani, Nadia Conti, Giovanna Dal Forno, Aldo Feriani, Daniele Donati, Carla Marchioro, Tommaso Messeri, Andrea Missio, Alessandra Pasquarello, Giorgio Pentassuglia, Domenica A. Pizzi, Stefano Provera, Anna M. Quaglia, Fabio Maria Sabbatini,
A series of benzoazepine derivatives, bearing suitable substituents at the C-3 position, was designed and evaluated by superimposition with the pharmacophore model of the glycine binding site. To fully explore the SAR of this class of compounds and to allow the preparation of new different compounds at the C-3 position, appropriate synthetic routes were set up. The benzoazepines were evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions ...
Tópico(s): Epilepsy research and treatment
2003 - Elsevier BV | Il Farmaco
Antonella Marangoni, Erika Fiorino, Federica Gilardi, Rita Aldini, Elena Scotti, Paola Nardini, Claudio Foschi, Manuela Donati, Marco Montagnani, Monica Cevenini, Placido Franco, Aldo Roda, Maurizio Crestani, Roberto Cevenini,
Objective Chlamydia pneumoniae has been linked to atherosclerosis, strictly associated with hyperlipidemia. The liver plays a central role in the regulation of lipid metabolism. Since in animal models C. pneumoniae can be found at hepatic level, this study aims to elucidate whether C. pneumoniae infection accelerates atherosclerosis by affecting lipid metabolism. Methods Thirty Balb/c mice were challenged intra-peritoneally with C. pneumoniae elementary bodies and thirty with Chlamydia trachomatis, ...
Tópico(s): Phytoestrogen effects and research
2015 - Elsevier BV | Atherosclerosis
Francesca Paolini, Pietro Donati, A. Amantea, S. Bucher, Emilia Migliano, Aldo Venuti,
Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of elderly or immunosuppressed patients. Clonal integration of a new human polyomavirus, the Merkel cell polyomavirus (MCPyV), has been reported in MCC patients. The main objective of the study was the detection of MCPyV and viral expression in clinical samples of Italian patients who were diagnosed MCC.DNA and RNA were extracted from nine MCCs to detect the presence of MCPyV. Viral large T gene (LT1 and LT3), and viral capsid ...
Tópico(s): Antenna Design and Analysis
2011 - BioMed Central | Virology Journal
Pietro Donati, Luca Muscardin, A. Amantea, Francesca Paolini, Aldo Venuti,
Incontinentia pigmenti (IP) is an X-linked dominant disorder, which occurs in female patients. We present a typical case of IP with subungual tumors (STIP) together with a short review on subungual tumors in IP. The diagnosis was achieved on the basis of the onset in adult life of STIP together with the other specific symptoms like ocular and dental abnormalities and achromic lesions of the legs. In the STIP lesions the presence and, in one of them, the expression, of HPV type 15 were detected. Topical ...
Tópico(s): Dermatologic Treatments and Research
2009 - John Libbey Eurotext | European Journal of Dermatology
Susanna Stea, M. Visentin, Maria Benedetta Donati, Donatella Granchi, G. Ciapetti, A Sudanese, Aldo Toni,
Nineteen patients who had undergone hip revision surgery for aseptic loosening of joint prostheses were studied. Tissue samples were harvested at the interface between bone and implant, either at the stem or at the cotyle level. Immunohistochemistry was performed on tissue sections to detect nitric oxide synthase (NOS), the enzyme which enables the synthesis of nitric oxide (NO), a molecule which can activate bone resorption. Quantitative analysis of the positive cells and correlation with the presence ...
Tópico(s): Orthopaedic implants and arthroplasty
2002 - Elsevier BV | Biomaterials
Marco Chilosi, Gianpietro Semenzato, Cetto Gl, Alberto Ambrosetti, L Fiore-Donati, G. Perona, Giorgio Berton, Maurizio Lestani, Aldo Scarpa, Carlo Agostini,
Abstract In this study we provide evidence that the sera of patients with hairy cell leukemia (HCL) contain a factor that can prevent the binding of a monoclonal antibody specific for interleukin-2 receptor (IL-2R) to its target. This factor corresponds to the soluble form of IL-2R (sIL-2R), as assessed by a specific enzyme-linked immunosorbent assay test, and appears to be released by neoplastic hairy cells. The serum sIL-2R levels were very high at diagnosis and significantly reduced during recombinant ...
Tópico(s): Lymphoma Diagnosis and Treatment
1987 - Elsevier BV | Blood
Gennaro Franco, Pietro Donati, Luca Muscardin, Antonio Maini, Aldo Morrone,
SUMMARY We present a case series of 63 patients diagnosed with juxta‐clavicular beaded lines. This condition is more frequent in dark‐skinned people and corresponds to an anatomical variant of simple sebaceous hyperplasia. In view of the strong reactivity of the melanocytes in dark‐skinned people, and of the possible hypochromic results, no treatment is advised.
Tópico(s): Genetic and rare skin diseases.
2006 - Wiley | Australasian Journal of Dermatology
Beatrice Campi, Sabina Frascarelli, Elisabetta Pietri, Ilaria Massa, Caterina Donati, Roberto Bozic, Silvano Bertelloni, Aldo Paolicchi, Riccardo Zucchi, Alessandro Saba,
In the clinical laboratories, dehydroepiandrostenedione (DHEA) is usually quantified by immunoassay-based methods, which are often affected by cross-reactivity with endogenous interferences, such as 4-androsten-3β-ol-17-one. The interfering compounds lead to a poor accuracy of the measurements, mainly at a low concentration level. The present paper describes a validated method based on tandem mass spectrometry coupled to liquid chromatography, for the accurate quantification of DHEA in serum. The ...
Tópico(s): Pesticide Residue Analysis and Safety
2017 - Springer Science+Business Media | Analytical and Bioanalytical Chemistry
James Glasbey, Tom Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab Alameer, Sattar Alshryda, Alexis Arnaud, Brittany Bankhead-Kendall, Mohamad K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas‐Chavarri, Miguel F Cunha, Justine Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J.E.F. Fitzgerald, Maria Fourtounas, Alexander J. Fowler, K Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter J. Hutchinson, Gabriella Hyman, Arda Işık, Umesh Jayarajah, Haytham M.A. Kaafarani, Bryar Kadir, Ismaïl Lawani, Hans Lederhuber, Elizabeth Li, Markus Löffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D McClain, Kenneth A McLean, John G. Meara, Antonio Ramos‐De la Medina, Mengistu G Mengesha, Ana Minaya, María Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert M. Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabriëlle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana F F Simoes, Neil Smart, Richard Sullivan, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H Taylor, Mary L Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu, Omar Omar, Ewen M. Harrison, Aneel Bhangu, Kwabena Siaw-Acheampong, Ruth Benson, Edward Bywater, Brett E Dawson, Jonathan P Evans, Emily Heritage, Conor Jones, Sivesh K. Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew T. Knight, Samuel Lawday, Harvinder Mann, Ella J Marson, Siobhan C. McKay, Emily Mills, Gianluca Pellino, Abhinav Tiwari, Isobel M Trout, Richard Wilkin, Sadi A. Abukhalaf, Michel Adamina, Adesoji Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeier, Osaid Alser, Muhammad Alshaar, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany Bankhead-Kendall, Emma Barlow, David Beard, Ruth Blanco‐Colino, Amanpreet Brar, Ana Minaya‐Bravo, Kerry Breen, Chris Bretherton, Igor Lima Buarque, Josh Burke, Edward Caruana, Mohamad K. Abou Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moisés Cukier, Giana H. Davidson, Salomone Di Saverio, Thomas M Drake, John Edwards, Sameh Hany Emile, Shebani Farik, Samuel Ford, Tatiana Garmanova, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A. Griffiths, Magdalena Gruendl, Constantine Halkias, Intisar Hisham, Peter J. Hutchinson, Shelley Hwang, Michael D. Jenkinson, Pascal Jonker, Debby Keller, Angelos G. Kolias, Schelto Kruijff, Sezai Leventoğlu, Andrey Litvin, Andrew P. Loehrer, María Marta Modolo, Piotr Major, Hassan Mashbari, Symeon Metallidis, Helen Mohan, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionuț Negoi, Milagros Niquen-Jimenez, Maricarmen Olivos, Salah Eddine Oussama Kacimi, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Carlos J. Pérez-Rivera, Thomas Pinkney, Willemijn Y. van der Plas, Ahmad Uzair Qureshi, Dejan Radenković, Antonio Ramos‐De la Medina, Elliot John Revell, Keith Roberts, April Camilla Roslani, Martin Rutegård, Juan José Segura‐Sampedro, Irène Santos, Andrew Schache, Andreas A. Schnitzbauer, Justina O. Seyi‐Olajide, Neil Sharma, Caitlin Shaw, Sebastian Shu, Kjetil Søreide, Antonino Spinelli, Grant D. Stewart, Philip Townend, Georgios Tsoulfas, Raghavan Vidya, Dale Vimalachandran, Oliver Warren, Duane Wedderburn, NA EuroSurg, NA European Society of Coloproctology, NA Global Initiative for Children's Surgery, NA GlobalSurg, NA GlobalPaedSurg, NA ItSURG, NA PTSurg, NA SpainSurg, NA Italian Society of Colorectal Surgery, NA Association of Surgeons in Training, NA Irish Surgical Research Collaborative, NA Transatlantic Australasian Retroperitoneal Sarcoma Working, NA Italian Society of Surgical Oncology, Lesley Booth, Margaret Barker, Neil Barker, Shirley Cooke, Suzanne Doré, Nigel Horwood, Emmy Runigamugabo, Carrie Tierney Weir, Mike Bahrami-Hessari, Asad Riaz, Jaffer Shah, Mohammed Safi, Dariel Thereska, Irida Dajti, Riadh Cheddadi, Anisse Tidjane, Carlos A Quinteros, Ahmed khelfaoui, Kamel Ben Salem, Omar Riffi, Salah Eddine Oussama Kacimi, Salim Loudjedi, Tidjani Damerdji, Diana Alejandra Pantoja Pachajoa, René M. Palacios Huatuco, Fernando A. Alvarez, Alejandro Marcelo Doniquian, Roberto Ariel Abeldaño Zúñiga, Francisco Schlottmann, C. Cobos, Cecilia Gigena, Agustin Albani Forneris, Agustín Duro, Agustín García-Mansilla, Virginia Cano Busnelli, C. Poggi, Pedro Mercado, Marcos González, Agustina F Castro Lalin, Horacio F. Mayer, Rodrigo Brandariz, Pablo A. Slullitel, Rocio Boudou, Pablo Lobos, María C Uffelmann, María Laura Petersen, Emilia Luzzi, F. Lichtenberger, María Amor, Celeste S Zarratea, Tomás Alfredo Esteves, Nicolas A Gemelli, Sebastián Tirapegui, Juan Liyo, Jordán Scherñuk, Luis Alejandro Boccalatte, Rubén Balmaceda, José Luis D’addino, M. Caubet, José Alfredo Calderón Arancibia, Carina Chwat, Brian Morris, Nicolás Avellaneda, Ivana Ines Pedraza Salazar, D Eskinazi, Lara Vargas, María Emilia Muriel, Stefano Lucchini, M. Gosselink, Amelia Davis, J. Barker, Kirby R. Qin, David Proud, Daniel Cox, Su Kah Goh, David S. Liu, Dan Wu, Neil D. Merrett, Sarit Badiani, Shomik Sengupta, Anshini Jain, Christopher Steen, Enoch Wong, C Ip, Matthew Leaning, Conor McCartney, Sivakumar Gananadha, Evie Yeap, Sean Stevens,
The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
Elsevier BV
L. Savarino, Susanna Stea, Donatella Granchi, M. Visentin, G. Ciapetti, Maria Benedetta Donati, Giuseppe Rollo, Gianfranco Zinghi, Arturo Pizzoferrato, Lucio Montanaro, Aldo Toni,
The quantification of sister chromatid exchange (SCE) during mitosis is a useful index for evaluating genotoxic effects in subjects occupationally or incidentally exposed to potentially toxic substances. The authors investigated the hypothesis that ions released by corrosion from prosthetic components of fracture fixation devices are associated with change in SCE incidence. In the present study, ten patients with implants were examined, and fifteen subjects with no implants were used as controls. ...
Tópico(s): Orthopaedic implants and arthroplasty
2000 - Wiley | Journal of Biomedical Materials Research
Romano Di Fabio, Roberto Arban, Giovanni Bernasconi, Simone Braggio, Frank E. Blaney, Anna Maria Capelli, Emiliano Castiglioni, Daniele Donati, Elettra Fazzolari, Emiliangelo Ratti, Aldo Feriani, Stefania Contini, Gabriella Gentile, Damiano Ghirlanda, Fabio Maria Sabbatini, Daniele Andreotti, Simone Spada, Carla Marchioro, Angela Worby, Yves St‐Denis,
In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochemical properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent phenyl ring and the nature of the heterocyclic moieties present in the upper region of the molecule. Selective and potent compounds have been discovered endowed with reduced ClogP with respect to compounds known in the literature. Of particular relevance was the finding that ...
Tópico(s): Hormonal Regulation and Hypertension
2008 - American Chemical Society | Journal of Medicinal Chemistry
Aldo Venuti, Pietro Donati, A. Amantea, L. Båluş,
Recently the presence of HPV in non-genital Bowen's disease has been found in few cases. We analysed 13 cases of bowenoid carcinoma by the following technical aapproachs: I ― Southern-blot to define the physical state of viral sequences in the cells; II ― in situ hybridization to identify the single cell infected by specific HPVs; III ― PCR to detect even a very low level of virus sequences. By these methods we have found HPV 16 DNA sequences in 4 of 13 patients with different topographic presentations ...
Tópico(s): Cancer Diagnosis and Treatment
1994 - John Libbey Eurotext | European Journal of Dermatology
Aldo Farencena, Maurizio Comanducci, Manuela Donati, Giulio Ratti, Roberto Cevenini,
A Chlamydia trachomatis urethral isolate, alpha/95, yielding pgp3-negative but otherwise normal inclusions by immunofluorescence also gave negative results when pCT-homologous DNA was searched by PCR and Southern blotting. omp-1 sequence analysis identified alpha/95 as a new genotype B variant. These findings confirm that pCT is not required for chlamydial growth in vitro.
Tópico(s): Urinary and Genital Oncology Studies
1997 - American Society for Microbiology | Infection and Immunity
Maurizio Pea, Franco Bonetti, Giuseppe Zamboni, Guido Martignoni, Maurizio Riva, Romano Colombari, Aldo Mombello, Mariella Bonzanini, Aldo Scarpa, Claudio Ghimenton, L Donati,
HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity was investigated in 10 cases of angiomyo-lipoma (AML) (1 with massive regional lymph node involvement) of the kidney and detected in all of them. No HMB-45 immunoreactivity was found in other tumors of the region which can occasionally be confused with AML, such as renal cell carcinoma, Wilms’ tumor, and retroperitoneal sarcoma (leiomyosarcoma and liposarcoma). These findings indicate that HMB-45 is not a melanocyte-restricted marker ...
Tópico(s): Tuberous Sclerosis Complex Research
1991 - Elsevier BV | Pathology
Claudio Azzolini, Aldo Torreggiani, Chiara M. Eandi, Simone Donati, Muna Al Oum, Riccardo Vinciguerra, Luigi Bartalena, Valerio Tartaglia,
We investigated the care of patients with age-related macular degeneration (AMD) managed via a physician-to-physician teleconsultation network for ophthalmology. Eleven groups of ophthalmologists took part in the study. The groups were located in 10 cities across Italy. Each group was based on a Retina Centre located at a university or hospital, with one or two expert ophthalmologists (20 expert ophthalmologists in total). In each region containing a Retina Centre, 6-10 general ophthalmologists (94 ...
Tópico(s): Retinal and Optic Conditions
2013 - SAGE Publishing | Journal of Telemedicine and Telecare