Amy Lloyd, Anna Martínez‐Muriana, Emma Davis, Michael J. Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J. Brenes, Linda V. Sinclair, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Strooper, Andrew J.M. Howden,
Using high-resolution quantitative mass spectrometry, we present comprehensive human and mouse microglia proteomic datasets consisting of over 11,000 proteins across six microglia groups. Microglia share a core protein signature of over 5,600 proteins, yet fundamental differences are observed between species and culture conditions. Mouse microglia demonstrate proteome differences in inflammation- and Alzheimer's disease-associated proteins. We identify differences in the protein content of ex vivo ...
Tópico(s): S100 Proteins and Annexins
2024 - Cell Press | Cell Reports
Hassan Ghomrawi, Carol A. Mancuso, Allison Dunning, Alejandro González Della Valle, Michael M. Alexiades, Charles N. Cornell, Thomas P. Sculco, Matthias Bostrom, David J. Mayman, Robert G. Marx, Geoffrey H. Westrich, Michael Odell, Alvin I. Mushlin,
Failure of THA or TKA to meet a patient's expectations may result in patient disappointment and litigation. However, there is little evidence to suggest that surgeons can consistently anticipate which patients will benefit from those interventions.To determine the ability of surgeons to identify, in advance of surgery, patients who will benefit from THA or TKA and those who will not, where 'benefit' is defined as a clinically important improvement in a validated patient-reported outcomes score.In ...
Tópico(s): Hip and Femur Fractures
2017 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Jason Pellettieri, Patrick Fitzgerald, Shigeki Watanabe, J Mancuso, Douglas R. Green, Alejandro Sánchez Alvarado,
Tópico(s): Marine Invertebrate Physiology and Ecology
2009 - Elsevier BV | Developmental Biology
Hassan Ghomrawi, Carol A. Mancuso, Alejandro González Della Valle, Christina Herrero, Geoffrey H. Westrich,
Background Stiffness complaints after total knee arthroplasty (TKA) are frequent, yet poorly understood and can be challenging for surgeons to address. The WOMAC stiffness subscale is a widely used measure of stiffness and can serve as a simple screening tool for complaints. Questions/Purposes We aimed to identify a threshold for stiffness complaints on the WOMAC stiffness subscale and investigate its overlap with range of motion (ROM) in TKA patients. Methods TKA patients were enrolled preoperatively ...
Tópico(s): Knee injuries and reconstruction techniques
2016 - SAGE Publishing | HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery
Diego Pol, Adriana Cecilia Mancuso, Roger M. H. Smith, Claudia A. Marsicano, Jahandar Ramezani, Ignacio A. Cerda, Alejandro Otero, Vincent Fernández,
Sauropodomorph dinosaurs dominated the herbivorous niches during the first 40 million years of dinosaur history (Late Triassic-Early Jurassic), yet palaeobiological factors that influenced their evolutionary success are not fully understood. For instance, knowledge on their behaviour is limited, although herding in sauropodomorphs has been well documented in derived sauropods from the Late Jurassic and Cretaceous. Here we report an exceptional fossil occurrence from Patagonia that includes over 100 ...
Tópico(s): Morphological variations and asymmetry
2021 - Nature Portfolio | Scientific Reports
Alejandro Vallejo, Pasquale Ferrante, Vincent Soriano, Maria Luisa Calabrò, Roberta Mancuso, Alonso Heredia, E. Mannella, Anna Favero, Alfredo García‐Sáiz, Luigi Chieco-Bianchi, Juan González‐Lahoz, Indira Hewlett,
Human T-cell lymphotropic virus type II (HTLV-II) has been subtyped into two major groups, IIa and IIb, according to molecular studies involving env gene sequencing. Subsequently, this retrovirus was further subclassified by examining the long terminal repeat (LTR), the most divergent genomic region. Sequence analysis and restriction fragment-length polymorphism (RFLP) applied to the LTR region identified either four or five groups within the IIa subtype (depending on the restriction enzyme sets used) ...
Tópico(s): Vector-Borne Animal Diseases
1996 - Lippincott Williams & Wilkins | Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology
Ana Vivancos, Héctor G. Pálmer, Zighereda Ogbah, Judit Matito, Francesco M. Mancuso, Alejandro Navarro, Alex Martinez Marti, Guillem Argilés, Elena Élez, Jordi Rodón, Paolo Nucíforo, Josep Tabernero, Enriqueta Felip,
e23235 Background: It is well recognized that mutations in downstream components of the canonical Wnt pathway (e.g. APCand beta-catenin) can contribute to tumorigenesis. Recently, genetic alterations in upstream regulators of the Wnt pathway, such as RNF43 and R-spondins, have also been implicated in tumorigenesis. RNF43 and its homolog ZNRF3 are E3 ubiquitin ligases that promote the degradation of the frizzled family of Wnt receptors. R-spondins, in turn, are secreted proteins that interact with ...
Tópico(s): Cancer-related Molecular Pathways
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Hani M. Babiker, Lisa E. Davis, Kristian Larson, Crystal Placencia, Connor Swensen, Pavan Tenneti, Melissa Siaw Han Lim, Ruth Cañamar, J. E. Curtis, Erica Castillo, James J. Mancuso, Diane Rensvold, Sarah Martinez, Lora Macias, Alejandro Recio‐Boiles, Sreenivasa R Chandana, Daruka Mahadevan,
Introduction: Early phase clinical trials are the first clinical research step to bringing new cancer therapeutics to patients. At this stage, a new drug's safety, dosing, and scheduling profiles are established as the main endpoints. However, excellent responses due to biomarker-guided and immune checkpoint trials in early phase have resulted in direct approvals of new anti-cancer drugs. Despite doubling of the success rate of new drug approvals, many barriers exist to expeditiously bring active ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2019 - Taylor & Francis | Expert Opinion on Investigational Drugs
Hassan Ghomrawi, Carol A. Mancuso, Alejandro González Della Valle, Michael M. Alexiades, Charles N. Cornell, Thomas P. Sculco, Mathias P. Bostrom, David J. Mayman, Robert G. Marx, Geoffrey H. Westrich, Alvin I. Mushlin,
To the Editor, We thank CORR for allowing us the opportunity to respond to the letter by Dr. Joseph Bernstein [1]. In commenting on the article by Fontana and colleagues [3], Dr. Bernstein noted our findings, which documented that most, but not all, patients who underwent TKA achieved the minimum thresholds for improvement in their function and pain relief, respectively [4]. Dr. Bernstein noted that our findings were bleaker than those by Bourne et al. [2] who found 20% dissatisfaction after surgery, ...
Tópico(s): Orthopedic Infections and Treatments
2020 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Eiman A. Ali, Aneesa Syed, Ludmila Khailová, John Iguidbashian, Alejandro Suarez‐Pierre, Jelena Klawitter, Matthew L. Stone, Christopher A Mancuso, Benjamin S. Frank, Jesse Davidson,
... Ali, Aneesa Syed, Ludmila Khailova, John P. Iguidbashian, Alejandro Suarez‐Pierre, Jelena Klawitter, Matthew Stone, Christopher A. Mancuso, Benjamin S. Frank and Jesse A. Davidson Eiman ... of Medicine, , Department of Surgery, , Aurora, , CO, , USA, , Alejandro Suarez‐PierreAlejandro Suarez‐Pierre https://orcid.org/0000-0003-1821-6240 , University of Colorado‐School of Medicine, , Department of Surgery, , Aurora, , CO, , USA, , Jelena KlawitterJelena Klawitter , University of Colorado‐School of Medicine, , Department of Anesthesiology, , Aurora, , CO, , USA, , Matthew StoneMatthew Stone , University of Colorado‐School of Medicine, , Department of Surgery, , Aurora, , CO, , USA, , Christopher A. MancusoChristopher A. Mancuso https://orcid.org/0000-0003-3081-2758 , University ...
Tópico(s): Neonatal Respiratory Health Research
2023 - Wiley | Journal of the American Heart Association
Sandra Bonache, I. Esteban, Alejandro Moles‐Fernández, Anna Tenés, Laura Duran-Lozano, Gemma Montalban, Vanessa Bach, Estela Carrasco, Neus Gadea, Adrià López‐Fernández, Sara Torres‐Esquius, Francesco M. Mancuso, Ginevra Caratù, Ana Vivancos, Noemí Tuset, Judith Balmañà, Sara Gutiérrez‐Enríquez, Orland Dı́ez,
Tópico(s): Genomics and Rare Diseases
2018 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
S. Cedrés, Enriqueta Felip, Cristina Cruz, A. Martinez de Castro, Núria Pardo, Alejandro Navarro, Alex Martínez‐Martí, J. Remon, Jorge Zerón-Medina, Judith Balmañà, Alba Llop‐Guevara, Josep M. Miquel, Irene Sansano, Paolo Nucíforo, Francesco M. Mancuso, Violeta Serra, Ana Vivancos,
Heat shock proteins (HSPs) are molecular chaperones that maintain proteins in their correct conformation to ensure stability and protect carcinoma cells from apoptosis. HSP90 inhibitors (HSP90i) block multiple targets simultaneously, and despite responses in a selected population, no HSP90i have yet been approved. We present a patient with a lung tumor with an exceptional response to cisplatin/gemcitabine in combination with HSP90i, which nowadays continues with HSP90i maintenance after three years. ...
Tópico(s): PARP inhibition in cancer therapy
2018 - Oxford University Press | JNCI Journal of the National Cancer Institute
Joan Frigola, Alejandro Navarro, Caterina Carbonell, Ana Callejo, Patricia Iranzo, S. Cedrés, Alex Martínez‐Martí, Núria Pardo, Nadia Saoudi, Eduardo Martínez de Dueñas, José Jimenez, Irene Sansano, Francesco M. Mancuso, Paolo Nucíforo, Luis M. Montuenga, Montse Sánchez‐Céspedes, Aleix Prat, Ana Vivancos, Enriqueta Felip, Ramon Amat,
Immunotherapy has transformed advanced non-small cell lung cancer (NSCLC) treatment strategies and has led to unprecedented long-lasting responses in some patients. However, the molecular determinants driving these long-term responses remain elusive. To address this issue, we performed an integrative analysis of genomic and transcriptomic features of long-term immune checkpoint inhibitors (ICIs)-associated responders. We assembled a cohort of 47 patients with NSCLC receiving ICIs that was enriched ...
Tópico(s): Lung Cancer Treatments and Mutations
2020 - Elsevier BV | Molecular Oncology
Pol Canal Noguer, Alejandro Requena Bermejo, Francesco M. Mancuso, Juan Carlos Higareda, Marina Manrique López, Marko Chersicola, Pablo Pérez‐Martínez, Pablo Antonio Camino, Primož Knap, Vivian Erklavec Zajec, Kristi Kruusmaa,
... of the patients. Citation Format: Pol Canal Noguer, Alejandro Requena Bermejo, Francesco Mattia Mancuso, Juan Carlos Higareda, Marina Manrique López, Marko Chersicola, ...
Tópico(s): RNA modifications and cancer
2023 - American Association for Cancer Research | Cancer Prevention Research
Alex Martínez‐Martí, Enriqueta Felip, Francesco M. Mancuso, Ginevra Caratù, Judit Matito, Paolo Nucíforo, Irene Sansano, Nely Díaz‐Mejía, S. Cedrés, Ana Callejo, Patricia Iranzo, Núria Pardo, Josep M. Miquel, Alejandro Navarro, Ana Vivancos, Miriam Sansó,
Tumour heterogeneity impacts the efficacy of metastatic cancer treatment even if actionable mutations are identified. Clinicians need to understand if assessing one lesion provides reliable information to drive a therapeutic decision in non-small-cell lung cancer (NSCLC) patients.We analysed inter-tumour heterogeneity from five autopsied individuals with NSCLC-harbouring mutations in the epidermal growth factor receptor (EGFR), treated with EGFR tyrosine kinase inhibitors (TKIs). Through a comprehensive ...
Tópico(s): Colorectal Cancer Treatments and Studies
2021 - Springer Nature | British Journal of Cancer
Debra Van Egeren, Khushi Kohli, Jeremy L. Warner, Philippe L. Bédard, Gregory J. Riely, Eva M. Lepisto, Deborah Schrag, Michele L. Lenoue-Newton, Paul J. Catalano, Kenneth L. Kehl, Franziska Michor, Michael V. Fiandalo, Margaret Foti, Yekaterina B. Khotskaya, Jocelyn Lee, Nicole Peters, Shawn M. Sweeney, Jean Abraham, James D. Brenton, Carlos Caldas, Gary J. Doherty, Birgit Nimmervoll, Karen Pinilla, José-Ezequiel Martín, Oscar M. Rueda, Stephen‐John Sammut, Dilrini Silva, Ka–Jia Cao, Allison P. Heath, Marilyn M. Li, Jena Lilly, Suzanne P. MacFarland, John M. Maris, Jennifer Mason, Allison M. Morgan, Adam Resnick, Mark Welsh, Yuankun Zhu, Bruce E. Johnson, Yvonne Li, Lynette M. Sholl, Ron Beaudoin, Roshni Biswas, Ethan Cerami, Oya Cushing, Deepa Dand, Matthew D. Ducar, Alexander Gusev, William C. Hahn, Kevin M. Haigis, Michael J. Hassett, Katherine A. Janeway, Pasi A. Jänne, Arundhati Jawale, Jason M. Johnson, Kenneth L. Kehl, Priti Kumari, Valerie Laucks, Eva M. Lepisto, Neal I. Lindeman, James Lindsay, Amanda Lueders, Laura E. MacConaill, Monica Manam, Tali Mazor, Diana Miller, Ashley Newcomb, John A. Orechia, Andrea Ovalle, Asha Postle, Daniel M. Quinn, Brendan Reardon, Barrett J. Rollins, Priyanka Shivdasani, Angela C. Tramontano, Eliezer M. Van Allen, Stephen C. Van Nostrand, Jonathan L. Bell, Michael Datto, Michelle Green, Chris Hubbard, Shannon J. McCall, Niharika B. Mettu, John H. Strickler, Fabrice André, Benjamin Besse, Marc Deloger, Semih Doğan, Antoîne Italiano, Yohann Loriot, Lacroix Ludovic, Stefan Michels, Jean Scoazec, Alicia Tran-Dien, Gilles Vassal, Christopher E. Freeman, Susan J. Hsiao, Matthew Ingham, Jiuhong Pang, Raúl Rabadán, Lira Camille Roman, Richard D. Carvajal, Raymond N. DuBois, Maria E. Arcila, Ryma Benayed, Michael F. Berger, Marufur Bhuiya, A. Rose Brannon, Samantha Brown, Debyani Chakravarty, Cynthia Chu, Ino de Bruijn, Jesse Galle, Jianjiong Gao, Stuart M. Gardos, Benjamin Groß, Ritika Kundra, Andrew L. Kung, Marc Ladanyi, Jessica A. Lavery, Xiang Li, Aaron Lisman, Brooke Mastrogiacomo, Caroline G. McCarthy, Chelsea Nichols, Angelica Ochoa, Katherine S. Panageas, John Philip, Shirin Pillai, Gregory J. Riely, Hira Rizvi, Julia E. Rudolph, Charles L. Sawyers, Deborah Schrag, Nikolaus Schultz, J. Schwartz, Robert P. Sheridan, David B. Solit, Avery Wang, Manda Wilson, Ahmet Zehir, Hongxin Zhang, Gaofei Zhao, Lailah Ahmed, Philippe L. Bédard, Jeffrey P. Bruce, Helen Chow, Sophie Cooke, Samantha Del Rossi, Sam Felicen, Sevan Hakgor, Prasanna Jagannathan, Suzanne Kamel‐Reid, Geeta Krishna, Natasha B. Leighl, Zhibin Lu, Alisha Nguyen, Leslie E. Oldfield, Demi Plagianakos, Trevor J. Pugh, Alisha Rizvi, Peter Sabatini, Elizabeth Shah, Nitthusha Singaravelan, Lillian L. Siu, Gunjan Srivastava, Natalie Stickle, Tracy Stockley, Marian Tang, Carlos Virtaenen, Stuart Watt, Celeste Yu, Brady Bernard, Carlo Bifulco, Julie Cramer, Soohee Lee, Brian Piening, Sheila M. Reynolds, Joseph Slagel, Paul Tittel, Walter J. Urba, Jake VanCampen, Roshanthi Weerasinghe, Alyssa Acebedo, Justin Guinney, Xindi Guo, Haley Hunter-Zinck, Thomas Yu, Kristen K. Dang, Valsamo Anagnostou, Alexander S. Baras, Julie R. Brahmer, Christopher D. Gocke, Robert B. Scharpf, Jessica J. Tao, Victor E. Velculescu, Shlece Alexander, Neil A. Bailey, Philip W. Gold, Mariska Bierkens, J. de Graaf, Jan Hudeček, Gerrit A. Meijer, Kim Monkhorst, Kris G. Samsom, Joyce Sanders, Gabe S. Sonke, Jelle ten Hoeve, Tony van de Velde, José van den Berg, Emile E. Voest, George F. Steinhardt, Sabah Kadri, Wanjari Pankhuri, Peng Wang, Jeremy P. Segal, Christine Moung, Carlos Espinosa-Mendez, Henry J. Martell, Courtney Onodera, Ana Quintanar Alfaro, E. Alejandro Sweet‐Cordero, Eric Talevich, Michelle L. Turski, Laura van’t Veer, Amanda Wren, Susana Aguilar, Rodrigo Dienstmann, Francesco M. Mancuso, Paolo Nucíforo, Josep Tabernero, Cristina Viaplana, Ana Vivancos, Ingrid Anderson, Sandip Chaugai, Joseph Coco, Daniel Fabbri, Doug Johnson, Leigh F. Jones, Xuanyi Li, Christine M. Lovly, Sanjay Mishra, Kathleen F. Mittendorf, Wen Li, Yuanchu James Yang, Chen Ye, Marilyn Holt, Michele L. Lenoue-Newton, Christine Micheel, Ben Ho Park, Samuel M. Rubinstein, Thomas Stricker, Lucy Lu Wang, Jeremy L. Warner, Meijian Guan, Guangxu Jin, Liang Liu, Ümit Topaloğlu, Cetin Urtis, Wei Zhang, Michael D’Eletto, Stephen Hutchison, Janina A. Longtine, Zenta Walther,
Abstract Patients with non-small cell lung cancer (NSCLC) who have distant metastases have a poor prognosis. To determine which genomic factors of the primary tumor are associated with metastasis, we analyzed data from 759 patients originally diagnosed with stage I–III NSCLC as part of the AACR Project GENIE Biopharma Collaborative consortium. We found that TP53 mutations were significantly associated with the development of new distant metastases. TP53 mutations were also more prevalent in patients ...
Tópico(s): RNA modifications and cancer
2022 - Nature Portfolio | Scientific Reports
Wanzirai Makoni, Lara Lorenzetti, Noah Mancuso, Ellen Luecke, Nhi Dinh, Ashwini Deshpande, Marie Shoen, Definate Nhamo, Francis M. Simmonds, Alejandro Baez, Thesla Palanee‐Phillips, Alexandra M. Minnis,
Tópico(s): HIV, Drug Use, Sexual Risk
2024 - Springer Science+Business Media | AIDS and Behavior
Yongjun Wang, Yuesong Pan, Hao Li, Pierre Amarenco, Hans Denison, Scott Evans, Anders Himmelmänn, Stefan James, Filip Birve, Per Ladenvall, Carlos A. Molina, S. Claiborne Johnston, Sebastián F. Ameriso, Leonardo Gonzalez, Pablo Ioli, Lorena Jure, Guillermo Povedano, Guadalupe Bruera, Gustavo Herrera, Juan Jose Martin Artesi, Virginia Pujol Lereis, Conrado J. Estol, Maia Gómez Schneider, Santiago Pigretti, Fernando Lipovestky, María Cristina Zurrú, Stephen C. Davis, Andrew Wong, Tissa Wijeratne, Arman Sabet, Andrew Lee, Vincent Thijs, Robin Lemmens, Laetitia Yperzeele, Geert Vanhooren, Peter Vanacker, Iris Vansteenkiste, Vicky Maqueda, André Peeters, M.C. Hasenbroekx, Wendy Van Daele, Adinda De Pauw, Regilio Oedit, Wouter De Vooght, Philippe Desfontaines, Yves Vandermeeren, Marianna DA Dracoulakis, Rodrigo Bazán, Octávio Marques Pontes‐Neto, Daniel DC Bezerra, Luiz Carlos Porcello Marrone, Pedro André Kowacs, Carla HC Moro, Paulo CO Macelino, Marco TA Pedatella, Еkaterina Titianova, Ivan Staikov, Dimitar Maslarov, Plamen Petkov, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Dimcho Hristov, Rumeliya Mitkova Ivanova, Margarita Velichkova Mihailova, Ashfaq Shuaib, Andrew M. Demchuk, Michel Beaudry, Anthony R Winder, Sumiti Nayar, Huaguang Zheng, Shuya Li, Xingquan Zhao, Guoqiang Wen, Xueshuang Dong, Guozhong Li, Zhaohui Zhang, Dawei Chen, Dong Wang, Xiaohong Li, Yun‐Cheng Wu, Xu Zhang, Baorong Zhang, Wenke Hong, Xiaogang Li, Lijuan Wang, Li Liu, Xiaolin Xu, Peifu Wang, Weihong Zheng, Jinsheng Zeng, Yukai Wang, Yan Jia, Yongqiu Li, Bo Hu, Wei Shen, Zhi Song, Zhiping Hu, Yunhai Liu, Kaifu Ke, Deqin Geng, Shigang Zhao, Runxiu Zhu, Qiumin Qu, Xiuli Zhao, Qi Wan, Yunhua Yue, Huishan Du, Yijun Zhang, Y. Wang, Dongfang Li, Dongyu Wang, Yongqiang Li, Xufang Xie, Tingmin Yu, Qi Liu, Mingxiu Yang, Xiaoping Pan, Lijun Xu, Deen Xu, Gang Li, Chunxue Wang, Martin Roubec, Petr Geier, Daniel Václavík, Jiří Neumann, Jana Bednářová, Robert Mikulík, David Hlinovský, Pierre Amarenco, Charlotte Cordonnier, Igor Sibon, Caroline Arquizan, Sonia Alamowitch, Bertrand Lapergue, Jean‐Marc Olivot, Nicolas Raposo, Marie‐Hélène Mahagne, Emmanuel Touzé, G. Rodier, Stéphane Vannier, Yves Samson, Michaël Obadia, Emmanuel Ellie, B. Guillon, Serge Timsit, Yannick Béjot, Valérie Wolff, Didier Smadja, Aude Bagan-Triquenot, Pierre Garnier, Xavier Ducrocq, Peggy Reiner, Thierry Moulin, Frédéric Philippeau, Fernando Pico, Sébastien Richard, Joachim Röther, Jörg Berrouschot, Hassan Soda, Carsten Pohlmann, Christoph Terborg, Darius G. Nabavi, Rainer Dziewas, Martin Köhrmann, Jörg Glahn, Lars Marquardt, Bernd Kallmünzer, Karin Weißenborn, Ka Sing Wong, Yannie Soo, Richard Li, Wing Chi Fong, Siu H Li, Raymond Tak Fai Cheung, Kin Keung Yip, Joshua Fok, Michael YP Fu, Norbert Szegedi, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, Péter Diószeghy, Attila Csányi, Levente Kerényi, Valéria Nagy, László Szapáry, Dániel Bereczki, Sándor Molnár, Gyula Timár, András Folyovich, Mária Sátori, Ildikó Vastagh, Praveen Koganti, Rajnish Kumar, Atul Prasad, Vikram Sharma, Alok Verma, Indraneel Basu, Abu Z Ansari, Vijaya Pamidimukkala, B.S. Raghavendra, Vivek Junewar, Sumit Singh, Advait Prakash Kulkarni, Padma MV Srivastava, K Pramod, Sanjay Ganpat Ramteke, Jaideep Bansal, Kewal Krishan, Hrishikesh Kumar, Priyanka Vikas Kashyap, TCR Ramakrishnan, Gopal Rao Adrasetty, Amit Yeole, Rahul Baviskar, Giancarlo Agnelli, Danilo Toni, Stefano Ricci, Rossana Tassi, Giuseppe Micieli, Michelangelo Mancuso, Giovanni Orlandi, Alberto Chiti, Marialuisa Delodovici, Federico Carimati, Alessandro De Vito, Francesco Perini, Cinzia Finocchi, Tiziana Tassinari, Massimo Del Sette, Luisa Roveri, Andrea Zini, Guido Bigliardi, Francesca Romana Pezzella, Letizia Maria Cupini, Alessandro Adami, Giampaolo Tomelleri, Carla Zanferrari, Angel A Arauz Góngora, Minerva López Ruíz, Angelica Ruíz Franco, José OJ Chacon Romero, Fernando Cruz Castillo, José Luis Ruíz‐Sandoval, Jesús Daniel López Tapia, Edgar Alejandro Castillo Vargas, Fernando Góngora‐Rivera, Guillermo Rivera Martinez, Jorge Villarreal Careaga, Nilton Custodio, Oscar G. Pamo Reyna, Cesar A Castañeda, E. Javier Pretell, Nestor Najar, Julio C Perez, Luisa Cardoza, Carlos Chávez, Maria Reyes, Anna Członkowska, Waldemar Fryze, Piotr Sobolewski, Ryszard Nowak, Dorota Szkopek, Zbigniew Bąk, Sławomir Brzozowski, Waldemar Brola, Marek Zalisz, Konrad Rejdak, Marta Bilik, Małgorzata Fudala, Andrzej Tutaj, Anetta Lasek‐Bal, Jan Kochanowicz, Bartosz Karaszewski, Tomasz Berkowicz, Jacek Zwiernik, Dorota Różański, Jan P. Mejnartowicz, Stefan Jurga, J Rózniecki, Maciej Świat, Ovidiu Băjenaru, Cristina Panea, Mihaela Simu, Rodica Bălașa, Dan L Cuciureanu, Bogdan Popescu, M Sabău, Corina Roman-Filip, Liudmila Odnopozova, Oleg Artyukov, A. S. Milto, Liudmila Vitalievna Stakhovskaya, Sergei Aksentiev,
Prior trials of dual antiplatelet therapy excluded patients with moderate ischemic stroke. These patients were included in the Acute Stroke or Transient Ischaemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death (THALES) trial, but results have not been reported separately, raising concerns about safety and efficacy in this subgroup.To evaluate the efficacy and safety of ticagrelor plus aspirin in patients with moderate ischemic stroke (National Institutes of Health Stroke ...
American Medical Association
Kenneth L. Kehl, Gregory J. Riely, Eva M. Lepisto, Jessica A. Lavery, Jeremy L. Warner, Michele L. Lenoue-Newton, Shawn M. Sweeney, Julia E. Rudolph, Samantha Brown, Celeste Yu, Philippe L. Bédard, Deborah Schrag, Katherine S. Panageas, Shawn M. Sweeney, Margaret Foti, Yekaterina B. Khotskaya, Michael V. Fiandalo, Benjamin E. Gross, Nikolaus Schultz, Brooke Mastrogiacomo, Mahdi Sarmardy, Marilyn M. Li, Adam Resnick, Angela J. Waanders, Jena Lilly, Richard D. Carvajal, Raúl Rabadán, Matthew Ingham, Susan Hsaio, Jean Abraham, James D. Brenton, Oscar M. Rueda, Carlos Caldas, Mikel Valgañón, Dilrini Silva, Chris Boursnell, Raquel Rodríguez-García, E. Vargaz Rodriguez, Birgit Nimmervoll, Ethan Cerami, Matthew D. Ducar, Priti Kumari, Neal I. Lindeman, Laura MacConnaill, John A. Orechia, Deborah Schrag, Priyanka Shivdasani, Eliezer M. Van Allen, Jason M. Johnson, Pasi A. Jänne, Eva M. Lepisto, Michael J. Hassett, Sindy Pimentel, Parin Sripakdeevong, Katherine A. Janeway, Jason M. Johnson, Matthew Meyerson, Daniel M. Quinn, Oya Cushing, Kevin M. Haigis, Diana Miller, Kenneth L. Kehl, Alexander Gustav, Angela C. Tramontano, Simon Arango Baquero, Jonathan L. Bell, Michelle Green, Shannon J. McCall, Michael Datto, Fabien Calvo, Fabrice André, Meurice Guillaume, Semih Doğan, Lacroix Ludovic, Jean Scoazec, Monica Ardenos, Gilles Vassal, Stefan Michels, Victor E. Velculescu, Alexander S. Baras, Christopher D. Gocke, Julie R. Brahmer, Charles L. Sawyers, David B. Solit, Stuart M. Gardos, Mike Berger, Marc Ladanyi, Gregory J. Riely, S. Joseph Sirintrapun, Ari Caroline, Stacy B. Thomas, Andrew Zarski, Ahmet Zehir, Alexia Iasonosa, John Philip, Samantha Brown, Andrew L. Kung, Ritika Kundra, Julia E. Rudolph, Jessica A. Lavery, Hira Rivzi, J. Schwartz, Caroline McCarthy, Maufur Bhuiya, Axel Martin, Cynthia Chu, Raymond DuBois, Tony van de Velde, Gerrit A. Meijer, Hugo M. Horlings, Harm van Tinteren, Martijn P. Lolkema, Les Nijman, Mariska Bierkens, Jelle ten Hoeve, Emilie Voest, Annemieke C. Hiemstra, Gabe S. Sonke, Jacques Craenmehr, Jan Hudeček, Kim Monkhorst, Walter J. Urba, Brady Bernard, Brian Piening, Carlo Bifulco, Paul Tittel, Julie Cramer, Justin Guinney, Celeste Yu, Xindi Guo, Alyssa Acebedo, Philip W. Gold, Neil A. Bailey, Sabah Kadri, Jeremy P. Segal, Wanjari Pankhuri, Peng Wang, Steinhardt George, Moung Christine, Laura van’t Veer, Eric Talevich, Amanda Wren, E. Alejandro Sweet‐Cordero, Michelle L. Turski, Philippe L. Bédard, Suzanne Kamel‐Reid, Zhibin Lu, Trevor J. Pugh, Lillian L. Siu, Stuart Watt, Natasha B. Leighl, Celeste Yu, Lailah Ahmed, Geeta Krishna, Carlos Virtaenen, Helen Chow, Demi Plagianakos, Samantha Del Rossi, Nitthusha Singaravelan, Sevan Hakgor, Nazish Qazi, Alisha Nguyen, Natalie Stickle, Thomas Stricker, Christine Micheel, Ingrid Anderson, Leigh F. Jones, Lucy Lu Wang, Christine M. Lovly, Michele LeNoue Newton, Ben Park, Jeremy L. Warner, Daniel Fabbri, Joseph Coco, Chen Ye, Sandip Chaugai, Sanjay Mishra, Yuanchu James Yang, Wen Li, Rodrigo Dienstmann, Susana Aguilar Izquierdo, Cristina Viaplana Donato, Francesco M. Mancuso, Ümit Topaloğlu, Liang Liu, Meijian Guan, Wei Zhang, Guangxu Jin, James C. Knight, Michael D’Eletto, E. Zeynep Ormay, Shrikant Mane, Kaya Bilgüvar, Walther Zenta, Daniel Dykas,
Importance Contemporary observational cancer research requires associating genomic biomarkers with reproducible end points; overall survival (OS) is a key end point, but interpretation can be challenging when multiple lines of therapy and prolonged survival are common. Progression-free survival (PFS), time to treatment discontinuation (TTD), and time to next treatment (TTNT) are alternative end points, but their utility as surrogates for OS in real-world clinicogenomic data sets has not been well characterized. ...
Tópico(s): Genetic factors in colorectal cancer
2021 - American Medical Association | JAMA Network Open
Samantha Brown, Jessica A. Lavery, Ronglai Shen, Axel Martin, Kenneth L. Kehl, Shawn M. Sweeney, Eva M. Lepisto, Hira Rizvi, Caroline G. McCarthy, Nikolaus Schultz, Jeremy L. Warner, Ben Ho Park, Philippe L. Bédard, Gregory J. Riely, Deborah Schrag, Katherine S. Panageas, Shawn M. Sweeney, Margaret Foti, Yekaterina B. Khotskaya, Michael V. Fiandalo, Benjamin Groß, Nikolaus Schultz, Brooke Mastrogiacomo, Mahdi Sarmardy, Marilyn M. Li, Adam Resnick, Angela J. Waanders, Jena Lilly, Richard D. Carvajal, Raúl Rabadán, Matthew Ingham, Susan Hsaio, Jean Abraham, James D. Brenton, Oscar M. Rueda, Carlos Caldas, Mikel Valgañón, Dilrini Silva, Chris Boursnell, Raquel Rodríguez-García, Ezequiel Rodriguez, Birgit Nimmervoll, Ethan Cerami, Matthew D. Ducar, Priti Kumari, Neal I. Lindeman, Laura MacConnaill, John A. Orechia, Deborah Schrag, Priyanka Shivdasani, Eliezer M. Van Allen, Jason M. Johnson, Pasi A. Jänne, Eva M. Lepisto, Michael J. Hassett, Sindy Pimentel, Parin Sripakdeevong, Katherine A. Janeway, Jason M. Johnson, Matthew Meyerson, Daniel M. Quinn, Oya Cushing, Kevin M. Haigis, Diana Miller, Kenneth L. Kehl, Alexander Gustav, Angela C. Tramontano, Simon Arango Baquero, Jonathan L. Bell, Michelle Green, Shannon J. McCall, Michael Datto, Fabien Calvo, Fabrice André, Meurice Guillaume, Semih Doğan, Lacroix Ludovic, Jean Scoazec, Monica Ardenos, Gilles Vassal, Stefan Michels, Victor E. Velculescu, Alexander S. Baras, Christopher D. Gocke, Julie R. Brahmer, Charles L. Sawyers, David B. Solit, Stuart M. Gardos, Mike Berger, Marc Ladanyi, Gregory J. Riely, S. Joseph Sirintrapun, Katherine S. Panageas, Ari Caroline, Stacy B. Thomas, Andrew Zarski, Ahmet Zehir, Alexia Iasonosa, John Philip, Samantha Brown, Andrew L. Kung, Ritika Kundra, Julia E. Rudolph, Jessica A. Lavery, Hira Rivzi, J. Schwartz, Caroline G. McCarthy, Maufur Bhuiya, Axel Martin, Cynthia Chu, Raymond N. DuBois, Tony van de Velde, Gerrit A. Meijer, Hugo M. Horlings, Harm van Tinteren, Martijn P. Lolkema, Les Nijman, Mariska Bierkens, Jelle ten Hoeve, Emilie Voest, Annemieke C. Hiemstra, Gabe S. Sonke, Jacques Craenmehr, Jan Hudeček, Kim Monkhorst, Walter J. Urba, Brady Bernard, Brian Piening, Carlo Bifulco, Paul Tittel, Julie Cramer, Justin Guinney, Celeste Yu, Xindi Guo, Alyssa Acebedo, Philip W. Gold, Neil A. Bailey, Sabah Kadri, Jeremy P. Segal, Wanjari Pankhuri, Peng Wang, Steinhardt George, Moung Christine, Laura van’t Veer, Eric Talevich, Amanda Wren, E. Alejandro Sweet‐Cordero, Michelle L. Turski, Philippe L. Bédard, Suzanne Kamel‐Reid, Zhibin Lu, Trevor J. Pugh, Lillian L. Siu, Stuart Watt, Natasha B. Leighl, Celeste Yu, Lailah Ahmed, Geeta Krishna, Carlos Virtaenen, Helen Chow, Demi Plagianakos, Samantha Del Rossi, Nitthusha Singaravelan, Sevan Hakgor, Nazish Qazi, Alisha Nguyen, Natalie Stickle, Thomas Stricker, Christine Micheel, Ingrid Anderson, Leigh F. Jones, Lucy Lu Wang, Christine M. Lovly, Michele LeNoue Newton, Ben Park, Jeremy L. Warner, Daniel Fabbri, Joseph Coco, Chen Ye, Sandip Chaugai, Sanjay Mishra, Yuanchu James Yang, Wen Li, Rodrigo Dienstmann, Susana Aguilar Izquierdo, Cristina Viaplana Donato, Francesco M. Mancuso, Ümit Topaloğlu, Liang Liu, Meijian Guan, Wei Zhang, Guangxu Jin, James C. Knight, Michael D’Eletto, E. Zeynep Ormay, Shrikant Mane, Kaya Bilgüvar, Walther Zenta, Daniel Dykas,
Real-world data sets that combine clinical and genomic data may be subject to left truncation (when potential study participants are not included because they have already passed the milestone of interest at the time of study recruitment). The lapse between diagnosis and molecular testing can present analytic challenges and threaten the validity and interpretation of survival analyses.Effects of ignoring left truncation when estimating overall survival are illustrated using data from the American ...
Tópico(s): Colorectal Cancer Treatments and Studies
2021 - American Medical Association | JAMA Oncology
Pierre Amarenco, Hans Denison, Scott Evans, Anders Himmelmänn, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A. Molina, Yongjun Wang, S. Claiborne Johnston, Kenneth Butcher, Shuya Li, Huaguang Zheng, David Školoudík, Ka Sing Wong, К С Мешкова, Nijasri C. Suwanwela, Sebastián F. Ameriso, Leonardo Gonzalez, Pablo Ioli, Lorena Jure, Guillermo Povedano, Guadalupe Bruera, Gustavo Herrera, Juan Jose Martin Artesi, Virginia Pujol Lereis, Conrado J. Estol, Maia Gómez Schneider, Santiago Pigretti, Fernando Lipovestky, María Cristina Zurrú, Stephen C. Davis, Andrew Wong, Tissa Wijeratne, Arman Sabet, Andrew Lee, Vincent Thijs, Robin Lemmens, Laetitia Yperzeele, Geert Vanhooren, Peter Vanacker, Iris Vansteenkiste, Vicky Maqueda, André Peeters, Van Daele Marie-Christine Hasenbroekx, Wendy Hasenbroekx, Adinda De Pauw, Regilio Oedit, Wouter De Vooght, Philippe Desfontaines, Yves Vandermeeren, Adinda De Pauw, Marianna Deway Andrade Dracoulakis, Rodrigo Bazán, Octávio Marques Pontes‐Neto, Daniel Bezerra, Luiz Carlos Porcello Marrone, Pedro André Kowacs, Carla Heloísa Cabral Moro, Paulo Cesar Otero Macelino, Marco Túlio Araújo Pedatella, Еkaterina Titianova, Ivan Staikov, Dimitar Maslarov, Plamen Petkov, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Dimcho Hristov, Rumeliya Mitkova Ivanova, Margarita Velichkova Mihailova, Ashfaq Shuaib, Andrew M. Demchuk, Michel Beaudry, Anthony R Winder, Sumiti Nayar, Xingquan Zhao, Guoqiang Wen, Xueshuang Dong, Guozhong Li, Zhaohui Zhang, Dawei Chen, Dong Wang, Xiaohong Li, Yun‐Cheng Wu, Xu Zhang, Baorong Zhang, Wenke Hong, Xiaogang Li, Lijuan Wang, Li Liu, Xiaolin Xu, Peifu Wang, Weihong Zheng, Jinsheng Zeng, Yukai Wang, Yan Jia, Yongqiu Li, Bo Hu, Wei Shen, Zhi Song, Zhiping Hu, Yunhai Liu, Kaifu Ke, Deqin Geng, Shigang Zhao, Runxiu Zhu, Qiumin Qu, Xiuli Zhao, Qi Wan, Yunhua Yue, Huishan Du, Yijun Zhang, Y. Wang, Dongfang Li, Dongyu Wang, Yongqiang Li, Xufang Xie, Tingmin Yu, Qi Liu, Mingxiu Yang, Xiaoping Pan, Lijun Xu, Deen Xu, Gang Li, Chunxue Wang, Martin Roubec, Petr Geier, Daniel Václavík, Jiří Neumann, Jana Bednářová, Robert Mikulík, David Hlinovský, Charlotte Cordonnier, Igor Sibon, Caroline Arquizan, Sonia Alamowitch, Bertrand Lapergue, Jean‐Marc Olivot, Nicolas Raposo, Marie‐Hélène Mahagne, Emmanuel Touzé, G. Rodier, Stéphane Vannier, Yves Samson, Michaël Obadia, Emmanuel Ellie, B. Guillon, Serge Timsit, Yannick Béjot, Valérie Wolff, Didier Smadja, Aude Bagan-Triquenot, Pierre Garnier, Xavier Ducrocq, Peggy Reiner, Thierry Moulin, Frédéric Philippeau, Fernando Pico, Sébastien Richard, Joachim Röther, Jörg Berrouschot, Hassan Soda, Carsten Pohlmann, Christoph Terborg, Darius G. Nabavi, Rainer Dziewas, Martin Köhrmann, Jörg Glahn, Lars Marquardt, Bernd Kallmünzer, Karin Weißenborn, Yannie Soo, Richard Li, Wing Chi Fong, Siu Hung Li, Raymond Tak Fai Cheung, Kin Keung Yip, Joshua Wai Ming Fok, Michael Yat Pang Fu, Norbert Szegedi, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, Péter Diószeghy, Attila Csányi, Levente Kerényi, Valéria Nagy, László Szapáry, Dániel Bereczki, Sándor Molnár, Gyula Timár, András Folyovich, Mária Sátori, Ildikó Vastagh, Praveen Satish Kumar, Rajnish Kumar, Atul Prasad, Vikram Sharma, Alok Verma, Indraneel Basu, Abu Zafar Ansari, Vijaya Pamidimukkala, B.S. Raghavendra, S, Vivek Junewar, Sumit Singh, Advait Prakash Kulkarni, Padma MV Srivastava, K. Pramod, Sanjay Ganpat Ramteke, Jaideep Bansal, Kewal Krishan, Hrishikesh Kumar, Priyanka Vikas Kashyap, Tirppur C. R. Ramakrishnan, Gopal Rao Adrasetty, Amit Yeole, Rahul Baviskar, Giancarlo Agnelli, Danilo Toni, Stefano Ricci, Rossana Tassi, Giuseppe Micieli, Michelangelo Mancuso, Giovanni Orlandi, Alberto Chiti, Marialuisa Delodovici, Federico Carimati, Alessandro De Vito, Francesco Perini, Cinzia Finocchi, Tiziana Tassinari, Massimo Del Sette, Luisa Roveri, Andrea Zini, Guido Bigliardi, Francesca Romana Pezzella, Letizia Maria Cupini, Alessandro Adami, Giampaolo Tomelleri, Carla Zanferrari, Antonio Araúz, Minerva López Ruíz, Angelica Ruíz Franco, José Omar Javier Chacon Romero, Fernando Cruz Castillo, José Luis Ruíz‐Sandoval, Jesús Daniel López Tapia, Edgar Alejandro Castillo Vargas, Fernando Góngora‐Rivera, Guillermo Rivera Martinez, Jorge Villarreal Careaga, Nilton Custodio, Oscar G. Pamo Reyna, Cesar A Castañeda, E. Javier Pretell, Nestor Najar, J. C. Pérez, Luisa Cardoza, Carlos M. Chavez, Maria Reyes, Anna Członkowska, Waldemar Fryze, Piotr Sobolewski, Ryszard Nowak, Dorota Szkopek, Zbigniew Bąk, Sławomir Brzozowski, Waldemar Brola, Marek Zalisz, Konrad Rejdak, Marta Bilik, Małgorzata Fudala, Andrzej Tutaj, Anetta Lasek‐Bal, Jan Kochanowicz, Bartosz Karaszewski, Tomasz Berkowicz, Jacek Zwiernik, Dorota Różański, Jan P. Mejnartowicz, Stefan Jurga, J Rózniecki, Maciej Świat, Ovidiu Băjenaru, Cristina Panea, Mihaela Simu, Rodica Bălașa, Dan Iulian Cuciureanu, Bogdan Ovidiu Popescu, M Sabău, Corina Roman-Filip, Liudmila Odnopozova, Oleg Artyukov,
Among patients with a transient ischemic attack or minor ischemic strokes, those with ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk of recurrent vascular events.
Lippincott Williams & Wilkins
Pierre Amarenco, Hans Denison, Scott Evans, Anders Himmelmänn, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A. Molina, Yongjun Wang, S. Claiborne Johnston, Sebastián Ameriso, Leonardo Gonzalez, Pablo Ioli, Lorena Jure, Guillermo Povedano, Guadalupe Bruera, Gustavo Herrera, Juan Jose Martin Artesi, Virginia Pujol Lereis, Conrado J. Estol, Maia Gómez Schneider, Santiago Pigretti, Fernando Lipovestky, María Cristina Zurrú, Stephen C. Davis, Andrew Wong, Tissa Wijeratne, Arman Sabet, Andrew Lee, Vincent Thijs, Robin Lemmens, Laetitia Yperzeele, Geert Vanhooren, Peter Vanacker, Iris Vansteenkiste, Vicky Maqueda, André Peeters, M.C. Hasenbroekx, Wendy Van Daele, Adinda De Pauw, Regilio Oedit, Wouter De Vooght, Philippe Desfontaines, Yves Vandermeeren, Marianna Deway Andrade Dracoulakis, Rodrigo Bazán, Octávio Marques Pontes‐Neto, Daniel Bezerra, Luiz Carlos Porcello Marrone, Pedro André Kowacs, Carla Heloísa Cabral Moro, Paulo Cesar Otero Macelino, Marco Túlio Araújo Pedatella, Еkaterina Titianova, Ivan Staikov, Dimitar Maslarov, Plamen Petkov, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Dimcho Hristov, Rumeliya Mitkova Ivanova, Margarita Velichkova Mihailova, Ashfaq Shuaib, Andrew M. Demchuk, Michel Beaudry, Anthony R Winder, Sumiti Nayar, Huaguang Zheng, Shuya Li, Xingquan Zhao, Guoqiang Wen, Xueshuang Dong, Guozhong Li, Zhaohui Zhang, Dawei Chen, Dong Wang, Xiaohong Li, Yun‐Cheng Wu, Xu Zhang, Baorong Zhang, Wenke Hong, Xiaogang Li, Lijuan Wang, Li Liu, Xiaolin Xu, Peifu Wang, Weihong Zheng, Jinsheng Zeng, Yukai Wang, Yan Jia, Yongqiu Li, Bo Hu, Wei Shen, Zhi Song, Zhiping Hu, Yunhai Liu, Kaifu Ke, Deqin Geng, Shigang Zhao, Runxiu Zhu, Qiumin Qu, Xiuli Zhao, Qi Wan, Yunhua Yue, Huishan Du, Yijun Zhang, Y. Wang, Dongfang Li, Dongyu Wang, Yongqiang Li, Xufang Xie, Tingmin Yu, Qi Liu, Mingxiu Yang, Xiaoping Pan, Lijun Xu, Deen Xu, Gang Li, Chunxue Wang, Martin Roubec, Petr Geier, Daniel Václavík, Jiří Neumann, Jana Bednářová, Robert Mikulík, David Hlinovský, Pierre Amarenco, Charlotte Cordonnier, Igor Sibon, Caroline Arquizan, Sonia Alamowitch, Bertrand Lapergue, Jean‐Marc Olivot, Nicolas Raposo, Marie‐Hélène Mahagne, Emmanuel Touzé, G. Rodier, Stéphane Vannier, Yves Samson, Michaël Obadia, Emmanuel Ellie, B. Guillon, Serge Timsit, Yannick Béjot, Valérie Wolff, Didier Smadja, Aude Bagan-Triquenot, Pierre Garnier, Xavier Ducrocq, Peggy Reiner, Thierry Moulin, Frédéric Philippeau, Fernando Pico, Sébastien Richard, Joachim Röther, Jörg Berrouschot, Hassan Soda, Carsten Pohlmann, Christoph Terborg, Darius G. Nabavi, Rainer Dziewas, Martin Köhrmann, Jörg Glahn, Lars Marquardt, Bernd Kallmünzer, Karin Weißenborn, Ka Sing Wong, Yannie Soo, Richard Li, Wing Chi Fong, Siu Hung Li, Raymond Tak Fai Cheung, Kin Keung Yip, Joshua Wai Ming Fok, Michael Yat Pang Fu, Norbert Szegedi, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, Péter Diószeghy, Attila Csányi, Levente Kerényi, Valéria Nagy, László Szapáry, Dániel Bereczki, Sándor Molnár, Gyula Timár, András Folyovich, Mária Sátori, Ildikó Vastagh, Praveen Kumar S, Rajnish Kumar, Atul Prasad, Vikram Sharma, Alok Verma, Indraneel Basu, Abu Zafar Ansari, Vijaya Pamidimukkala, Raghavendra B.S., Vivek Junewar, Sumit Singh, Advait Prakash Kulkarni, Padma MV Srivastava, K Pramod, Sanjay Ganpat Ramteke, Jaideep Bansal, Kewal Krishan, Hrishikesh Kumar, Priyanka Vikas Kashyap, TCR Ramakrishnan, Gopal Rao Adrasetty, Amit Yeole, Rahul Baviskar, Giancarlo Agnelli, Danilo Toni, Stefano Ricci, Rossana Tassi, Giuseppe Micieli, Michelangelo Mancuso, Giovanni Orlandi, Alberto Chiti, Marialuisa Delodovici, Federico Carimati, Alessandro De Vito, Francesco Perini, Cinzia Finocchi, Tiziana Tassinari, Massimo Del Sette, Luisa Roveri, Andrea Zini, Guido Bigliardi, Francesca Romana Pezzella, Letizia Maria Cupini, Alessandro Adami, Giampaolo Tomelleri, Carla Zanferrari, Antonio Araúz, Minerva López Ruíz, Angelica Ruíz Franco, José Omar Javier Chacon Romero, Fernando Cruz Castillo, José Luis Ruíz‐Sandoval, Jesús Daniel López Tapia, Edgar Alejandro Castillo Vargas, Fernando Góngora‐Rivera, Guillermo Rivera Martinez, Jorge Villarreal Careaga, Nilton Custodio, Oscar G. Pamo Reyna, Cesar A Castañeda, E. Javier Pretell, Nestor Najar, J. C. Pérez, Luisa Cardoza, Carlos M. Chavez, Maria Reyes, Anna Członkowska, Waldemar Fryze, Piotr Sobolewski, Ryszard Nowak, Dorota Szkopek, Zbigniew Bąk, Sławomir Brzozowski, Waldemar Brola, Marek Zalisz, Konrad Rejdak, Marta Bilik, Małgorzata Fudala, Andrzej Tutaj, Anetta Lasek‐Bal, Jan Kochanowicz, Bartosz Karaszewski, Tomasz Berkowicz, Jacek Zwiernik, Dorota Różański, Jan P. Mejnartowicz, Stefan Jurga, J Rózniecki, Maciej Świat, Ovidiu Băjenaru, Cristina Panea, Mihaela Simu, Rodica Bălașa, Dan Iulian Cuciureanu, Bogdan Popescu, M Sabău, Corina Roman-Filip, Liudmila Odnopozova, Oleg Artyukov, A. S. Milto, Liudmila Vitalievna Stakhovskaya, Sergei Aksentiev, Svetlana E Chuprina, E B Kuznetsova,
Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke.
American Medical Association
Pol Canal Noguer, Kristi Kruusmaa, James Kinross, Vivian Erklavec Zajec, Špela Zavodnik, Alejandro Requena Bermejo, Francesco M. Mancuso, Marina Manrique López, Primož Knap, Marko Chersicola, Pablo Pérez‐Martínez, Fernando Trincado Alonso, Carme Nolla Colomer, Aasma Shaukat,
Tópico(s): Ferroptosis and cancer prognosis
2023 - Elsevier BV | Gastroenterology
Helena Verdaguer, Magda Guardiola-Fernandez, Francesco M. Mancuso, Daniel Acosta, Elvira Buxó, Jorge Hernando, Marc Díez, Berta Laquente, Iosune Baraibar, Javier Ros, Alejandro Garcia, Judit Matito, Ágatha Martín, Alexandre Sierra, Guillermo Villacampa, Cristina Molero, Josep M. Miquel, Ana Vivancos, Rodrigo Dienstmann, Teresa Macarulla,
e16805 Background: Somatic DDR mut have been reported in close to 10% of PC samples. In this study we investigate their predictive value for response to platinum-based chemotherapy. Methods: Case-control study with pts deriving response to oxaliplatin-based treatment (partial or complete response at any line) [n = 30] versus no response (progression in first restaging at 1 st line) [n = 18]. An in-house NGS panel test of 420 genes was performed on tumor samples. DDR mut were classified in 2 subgroups: (a) ...
Tópico(s): Genetic factors in colorectal cancer
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Dana M. Gwinn, E. Alejandro Sweet‐Cordero,
... reducing equivalents (DeBerardinis et al., 2007DeBerardinis R.J. Mancuso A. Daikhin E. Nissim I. Yudkoff M. Wehrli ...
Tópico(s): Amino Acid Enzymes and Metabolism
2013 - Elsevier BV | Molecular Cell
Alejandro Recio‐Boiles, Jessica Vondrak, Summana Veeravelli, James J. Mancuso, Kathylynn Saboda, Denise J. Roe, Irbaz Bin Riaz, Aaron J. Scott, Emad Elquza, Ali McBride, Hani M. Babiker,
Background: Only 15–20% of pancreatic ductal adenocarcinoma (PDAC) patients are upfront surgical candidates at presentation, and for this cohort of patients, the 5-year survival is a mere 20% despite adjuvant therapy. Previous data indicate that in clinical practice most of these cases are “borderline-resectable,” and there is currently no mature data on perioperative treatment. Methods: We performed a retrospective electronic chart review of patients with “borderline-resectable” PDAC treated at an ...
Tópico(s): Neuroendocrine Tumor Research Advances
2020 - AME Publishing Company | Annals of Pancreatic Cancer
Helena Verdaguer, M. Guardiola, Francesco M. Mancuso, D.A. Acosta Eyzaguirre, Elvira Buxó, Jorge Hernando, M. Díez García, Berta Laquente, I. Baraibar Argota, Javier Ros, Alejandro García‐Álvarez, Judit Matito, Amber Martin, A. Sierra, G. Villacampa Javierre, Cristina Molero, Josep M. Miquel, Ana Vivancos, Rodrigo Dienstmann, T. Macarulla Mercadé,
Somatic DDR mut have been reported in close to 10% of PC samples. In this study we investigate their predictive value for response to platinum-based chemotherapy. Case-control study with pts deriving response to oxaliplatin-based treatment (partial or complete response at any line) [n=30] versus no response (progression in first restaging at 1st line) [n=18]. An in-house NGS panel test of 420 genes was performed on tumor samples. DDR mut were classified in 2 subgroups: (a) functional BRCA1, BRCA2 or ...
Tópico(s): Renal cell carcinoma treatment
2020 - Elsevier BV | Annals of Oncology
Pol Canal-Noguer, Alejandro Requena Bermejo, Špela Zavodnik, Vivian Erklavec Zajec, Francesco M. Mancuso, Marina Manrique López, Primož Knap, Marko Chersicola, Pablo Pérez‐Martínez, Fernando Trincado Alonso, Carme Nolla Colomer, Kristi Kruusmaa,
201 Background: Colorectal cancer (CRC) remains a leading cause of cancer related mortality worldwide. We utilized cell-free DNA (cfDNA) methylation and fragmentation characteristics of selected cancer-related biomarker regions and applied tumor-derived signal deduction and a machine learning algorithm to refine a blood test for the early detection of CRC. Methods: This was a prospective, international (Spain, Ukraine, Germany and USA [part of NCT04792684 study] population), observational cohort study. ...
Tópico(s): Colorectal Cancer Screening and Detection
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Chiara Pizzamiglio, Hallgeir Jonvik, Stefen Brady, Patrick F. Chinnery, Lucı́a Galan, Gráinne S. Gorman, Alejandro Horga, Rita Horváth, Mirian C. H. Janssen, Albert Lim, Michelangelo Mancuso, Robert McFarland, Mária Judit Molnár, Olimpia Musumeci, Victoria Nesbitt, Wladimir, Guido Primiano, Ernestina Santos, Serenella Servidei, Rhys H. Thomas, Michael G. Hanna, Pedro Machado, Robert D. S. Pitceathly,
Coronavirus 2019 (COVID-19), with more than 3 million deaths worldwide, is one of the deadliest pandemics in history. Patients with primary mitochondrial diseases (PMDs) are considered at high risk of complications. However, little is known about how COVID-19 affects this group. The aim of our study was to: (1) identify risk factors associated with hospitalisation; and (2) determine outcomes and long-term sequelae of COVID-19 in people with PMDs. Inclusion criteria included: (1) clinicopathological and/ ...
Tópico(s): Mitochondrial Function and Pathology
2021 - Elsevier BV | Journal of the Neurological Sciences
Jesse Davidson, John Iguidbashian, Ludmila Khailová, Tanner Lehmann, Alejandro Suarez‐Pierre, Lindsay M. Thomson, Jack Zakrzewski, Eiman Ali, Schuyler Lee, Benjamin S. Frank, Richard J. Ing, Matthew L. Stone, Suzanne Osorio Lujan, Sierra Niemiec, Christopher A Mancuso,
Tópico(s): Transplantation: Methods and Outcomes
2025 - Elsevier BV | Translational research