Dilara Akhoundova, Joaquín Mosquera, L. E. Musmann, Christian Britschgi, Cyrill Rütsche, Markus Rechsteiner, Ernest Nadal, M.R. García Campelo, Alessandra Curioni‐Fontecedro,
Liquid biopsy is a rapidly emerging tool of precision oncology enabling minimally invasive molecular diagnostics and longitudinal monitoring of treatment response. For the clinical management of advanced stage lung cancer patients, detection and quantification of circulating tumor DNA (ctDNA) is now widely adopted into clinical practice. Still, interpretation of results and validation of ctDNA-based treatment decisions remain challenging. We report here our experience implementing liquid biopsies ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Produção Nacional
Revisado por pares
Mayara Anselmi, Fernanda Junkes Corrêa, José R. Santos, Anatildes Feitosa Silva, João Antônio Cunha, Anderson H.F.F. Leão, Clarissa L. C. Campêlo, Alessandra Mussi Ribeiro, Regina H. Silva, Geison Souza Izídio,
The Lewis (LEW) and SHR (Spontaneously Hypertensive Rats) inbred rat strains differ in several anxiety/emotionality and learning/memory-related behaviors. We aimed to search quantitative trait locus (QTL) that influence these behaviors and confirm their effects in a congenic rat strain SLA16 (SHR.LEW.Anxrr16). LEW females and SHR males were intercrossed to produce F2 rats (96/sex), which were all tested in the plus-maze discriminative avoidance task (PMDAT), open-field (OF), object recognition (OR), spontaneous ...
Tópico(s): Adipose Tissue and Metabolism
2016 - Elsevier BV | Neurobiology of Learning and Memory
D. Ross Camidge, Hye Ryun Kim, Myung‐Ju Ahn, James Chih‐Hsin Yang, Ji‐Youn Han, Jong Seok Lee, Maximilian J. Hochmair, Jacky Yu-Chung Li, Gee‐Chen Chang, Ki Hyeong Lee, Cesare Gridelli, Angelo Delmonte, Rosario García Campelo, Dong‐Wan Kim, Alessandra Bearz, Frank Griesinger, Alessandro Morabito, Enriqueta Felip, Raffaele Califano, Sharmistha Ghosh, Alexander I. Spira, Scott Gettinger, Marcello Tiseo, Neeraj Gupta, J. Haney, David Kerstein, Sanjay Popat,
Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK-positive non-small-cell lung cancer (NSCLC) that is refractory to crizotinib. The efficacy of brigatinib, as compared with crizotinib, in patients with advanced ALK-positive NSCLC who have not previously received an ALK inhibitor is unclear.In an open-label, phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with advanced ALK-positive NSCLC who had not previously received ALK ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2018 - Massachusetts Medical Society | New England Journal of Medicine
Produção Nacional
Revisado por pares
José Augusto Teston, Janaina da Cruz Campelo, ALESSANDRA M.C. LOPES, Alexandre Specht,
The crimson speckled moth, Utetheisa pulchella (Linnaeus, 1758), is recorded in Brazilian Amazon for the first time. A moth (male) was collected with light trap in a multiple cropping area, in Mojuí dos Campos municipality, Pará State, Brazil. This record expands the area of occurrence and distribution of this rare species in the Neotropical Region. In addition, the occurrence of U. pulchella in the Amazon was unexpected, since this species is generally associated with open ecosystems and drier climates.
Tópico(s): Insect and Arachnid Ecology and Behavior
2019 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
Guilherme José Pimentel Lopes de Oliveira, Conrado Nogueira Campelo Rodrigues, Lívia Rodrigues Perussi, Alessandra Nara de Souza Rastelli, Rosemary Adriana Chiérici Marcantonio, Fábio Luiz Camargo Villela Berbert,
Objective: The purpose of this study was to evaluate the application of Er:YAG and Er,Cr:YSGG lasers during osteotomy in bovine bone blocks. Background data: Er:YAG/Er,Cr:YSGG lasers for osteotomy procedures have been used to induce tissue ablation without thermal damage. However, even these lasers can induce thermal damages, which can cause a delay on the bone healing. Materials and methods: Sixty standardized bovine bone mandible samples were divided into three groups with 20 samples each: Group ...
Tópico(s): Dental Implant Techniques and Outcomes
2016 - Mary Ann Liebert, Inc. | Photomedicine and Laser Surgery
Raffaele Califano, Maximilian J. Hochmair, Cesare Gridelli, Angelo Delmonte, M.R. García Campelo, Alessandra Bearz, Frank Griesinger, Alessandro Morabito, Enriqueta Felip, Sunita Ghosh, Marcello Tiseo, J. Haney, David Kerstein, Sanjay Popat, D. Ross Camidge,
Background: We report results of the first interim analysis (IA) from the ALTA-1L study of BRG vs CRZ in anaplastic lymphoma kinase (ALK) inhibitor–naive, ALK-positive non–small cell lung cancer (ALK+ NSCLC; NCT02737501). Methods: This open-label, multicenter study enrolled patients (pts) with advanced ALK+ NSCLC. Eligible pts had ≤1 prior systemic therapy for advanced NSCLC. Asymptomatic central nervous system (CNS) metastases were allowed. Pts were randomized 1:1 to BRG 180 mg QD with 7-day lead-in ...
Tópico(s): Cancer Genomics and Diagnostics
2019 - Elsevier BV | Annals of Oncology
Produção Nacional
Revisado por pares
Luan Felipe Campos Oliveira, Damila Rodrigues de Morais, Deleon Nascimento Correa, Jacqueline de Morais Campêlo, Alessandra Sussulini, Marcos N. Eberlin, Jandyson M. Santos,
Rationale The effort to make fake documents look real leads to the use of crickets and beverages to produce artificially aged papers, as land titles, based on yellowing caused by the use of these methods. An old practice in Brazil, called “cricketing”, has led to the misappropriation of Brazilian land using these documents. We propose a rapid, simple, instantaneous and non‐destructive method to identify artificially aged papers by easy ambient sonic‐spray ionization mass spectrometry (EASI‐MS) analysis. ...
Tópico(s): Analytical chemistry methods development
2021 - Wiley | Rapid Communications in Mass Spectrometry
Produção Nacional
Revisado por pares
Fernanda C. Cagni, Clarissa Loureiro das Chagas Campêlo, Daniel Gomes Coimbra, Mayara Rodrigues Barbosa, Luiz Gonzaga Oliveira Júnior, Antônio Braz Silva Neto, Alessandra Mussi Ribeiro, Clécio de Oliveira Godeiro Júnior, Tiago Gomes de Andrade, Regina H. Silva,
An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development ...
Tópico(s): Autism Spectrum Disorder Research
2016 - American Psychiatric Association Publishing | Journal of Neuropsychiatry
Produção Nacional
Revisado por pares
Anderson H.F.F. Leão, Ywlliane da Silva Rodrigues Meurer, Anatildes F. da Silva, André M. Medeiros, Clarissa L. C. Campêlo, Vanessa C. Abı́lio, Rovena C. G. K. Engelberth, Jeferson S. Cavalcante, Geison Souza Izídio, Alessandra Mussi Ribeiro, Regina H. Silva,
Reserpine is an irreversible inhibitor of vesicular monoamine transporter-2 (VMAT2) used to study Parkinson's disease (PD) and screening for antiparkinsonian treatments in rodents. Recently, the repeated treatment with a low-dose of reserpine was proposed as a progressive model of PD. Rats under this treatment show progressive catalepsy behavior, oral movements and spontaneous motor activity decrement. In parallel, compared to Wistar rats, spontaneously hypertensive rats (SHR) are resistant to acute ...
Tópico(s): Nuclear Receptors and Signaling
2017 - Frontiers Media | Frontiers in Aging Neuroscience
Produção Nacional
Revisado por pares
Priscila Tavares Macêdo, Antônio Carlos Queiroz de Aquino, Ywlliane da Silva Rodrigues Meurer, Luiz Eduardo Mateus Brandão, Clarissa L. C. Campêlo, Ramón Hypolito Lima, Marcos R. Costa, Alessandra Mussi Ribeiro, Regina H. Silva,
The cause of Alzheimer's disease (AD) remains uncertain. The accumulation of amyloid peptides (Aβ) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Frontiers Media | Frontiers in Aging Neuroscience
Produção Nacional
Revisado por pares
Clarissa L. C. Campêlo, José R. Santos, Anatildes F. Silva, Aline Lima Dierschnabel, André Luíz Bezerra de Pontes, Jeferson S. Cavalcante, Alessandra Mussi Ribeiro, Regina H. Silva,
Previous studies showed that the repeated administration with a low dose of reserpine (RES) induces a gradual appearance of motor signs and cognitive deficits compatible with parkinsonism in rodents. Environmental stimulation has neuroprotective effects in animal models of neurodegenerative damage, including acutely induced parkinsonism. We investigated the effects of exposure to an enriched environment (EE) on motor, cognitive and neuronal (levels of tyrosine hydroxylase, TH and brain derived neurotrophic ...
Tópico(s): Neurological disorders and treatments
2017 - Elsevier BV | Behavioural Brain Research
Rafael Rosell, Enric Carcereny, Radj Gervais, A. Vergnenègre, Bartomeu Massutí, Enriqueta Felip, Ramón Palmero, Ramón García-Gómez, Cinta Pallarés, José Miguel Sánchez, Rut Porta, Manuel Cobo, Pilar Garrido, Flavia Longo, Teresa Morán, Amelia Insa, Filippo de Marinis, R. Corre, Isabel Bover, Alfonso Illiano, Éric Dansin, Javier de Castro, Michèle Milella, Noemı́ Reguart, Giuseppe Altavilla, Ulpiano Jiménez, Mariano Provencio, Miguel Ángel Moreno, Josefa Terrasa, José Muñoz-Langa, Javier Valdivia, Dolores Isla, Manuel Dómine, Olivier Molinier, Julien Mazières, Nathalie Baize, Rosario Garcı́a-Campelo, G. Robinet, Delvys Rodríguez‐Abreu, Guillermo López-Vivanco, Vittorio Gebbia, Lioba Ferrera-Delgado, P. Bombaron, Reyes Bernabé, Alessandra Bearz, Á. Artal, Enrico Cortesi, Christian Rolfo, María Sanchez-Ronco, Ana Drozdowskyj, Cristina Queralt, Itziar de Aguirre, José Luis Ramírez, José Javier Sánchez, Miguel Ángel Molina‐Vila, Miquel Tarón, Luis Paz‐Ares,
Summary Background Erlotinib has been shown to improve progression-free survival compared with chemotherapy when given as first-line treatment for Asian patients with non-small-cell lung cancer (NSCLC) with activating EGFR mutations. We aimed to assess the safety and efficacy of erlotinib compared with standard chemotherapy for first-line treatment of European patients with advanced EGFR-mutation positive NSCLC. Methods We undertook the open-label, randomised phase 3 EURTAC trial at 42 hospitals in France, ...
Tópico(s): Colorectal Cancer Treatments and Studies
2012 - Elsevier BV | The Lancet Oncology
Produção Nacional
Revisado por pares
José R. Santos, João Antônio Cunha, Aline Lima Dierschnabel, Clarissa L. C. Campêlo, Anderson H.F.F. Leão, Anatildes F. Silva, Rovena Clara Galvão Januário Engelberth, Geison Souza Izídio, Jeferson S. Cavalcante, Vanessa C. Abı́lio, Alessandra Mussi Ribeiro, Regina H. Silva,
Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology. A previous study showed that the repeated administration with a low dose (0.1mg/kg) of the monoamine depleting agent reserpine induces a gradual appearance of motor signs of pharmacological parkinsonism ...
Tópico(s): Neurological disorders and treatments
2013 - Elsevier BV | Behavioural Brain Research
Neal Ready, Clarisse Audigier-Valette, Jonathan W. Goldman, Enriqueta Felip, Tudor‐Eliade Ciuleanu, M.R. García Campelo, Kevin Jao, Fabrice Barlési, Stéphanie Bordenave-Juchereau, Erika Rijavec, László Urbán, Jean-Sébastien Aucoin, Cristina Zannori, Karim Vermaelen, Osvaldo Arén Frontera, Alessandra Curioni‐Fontecedro, Amparo Sánchez-Gastaldo, Óscar Juan, Helena Linardou, Elena Poddubskaya, David R. Spigel, Samreen Ahmed, Michele Maio, Sunney Li, Han Chang, Joseph Fiore, A. Acevedo, Luis Paz‐Ares,
CheckMate 817, a phase 3B study, evaluated flat-dose nivolumab plus weight-based ipilimumab in patients with metastatic non-small cell lung cancer (NSCLC). Here, in this research, we report on first-line treatment in patients with Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1 (cohort A) and special populations (cohort A1: ECOG PS 2; or ECOG PS 0-1 with untreated brain metastases, renal impairment, hepatic impairment, or controlled HIV infection).Cohorts A and A1 received nivolumab ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2023 - BMJ | Journal for ImmunoTherapy of Cancer
Produção Nacional
Revisado por pares
Clarissa L. C. Campêlo, Fernanda C. Cagni, Diego de Siqueira Figueredo, Luiz Gustavo de Oliveira, Antônio B. Silva-Neto, Priscila Tavares Macêdo, José R. Santos, Geison Souza Izídio, Alessandra Mussi Ribeiro, Tiago Gomes de Andrade, Clécio Godeiro‐Júnior, Regina H. Silva,
Genetic susceptibility contributes to the etiology of sporadic Parkinson´s Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alpha-synuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (SNPs - rs2583988, rs356219, rs2736990 ...
Tópico(s): Neurological disorders and treatments
2017 - Frontiers Media | Frontiers in Aging Neuroscience
Produção Nacional
Revisado por pares
Larbi Mezian, Alexandra I.A. Chincha, Alessandra Vecchione, Emilia Ghelardi, José Matheus Camargo Bonatto, Anita J. Marsaioli, Pedro Henrique Campelo, Ibrahim Benamar, Abd Allah Moussaoui, Anderson S. Sant’Ana, Boumediene Moussa–Boudjemâa,
This study aimed to assess the counts and biodiversity characterization of aerobic sporeforming bacteria (ASB) in powdered infant formula (PIF). Fifty-four (n = 54) samples of PIF of three brands were analyzed for mesophilic aerobic bacteria, and ASB counts. ASB isolated from PIF were assessed for their ability to produce spoilage enzymes and hemolytic activity and further identified by MALDI-TOF mass spectrometry. Then, the isolates were subjected to rpoB gene typing and assessment of bceT, entFM, nhe ( ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2022 - Elsevier BV | International Journal of Food Microbiology
Produção Nacional
Revisado por pares
Sidney Gomes Azevedo, Ana Luisa Farias Rocha, Ronald Zico de Aguiar Nunes, Camila da Costa Pinto, Ştefan Ţălu, Henrique Duarte da Fonseca Filho, Jaqueline de Araújo Bezerra, Alessandra Ramos Lima, Francisco Eduardo Gontijo Guimarães, Pedro Henrique Campelo, Vanderlei Salvador Bagnato, Natália Mayumi Inada, EDGAR SANCHES,
Considerable efforts have been spent on environmentally friendly particles for the encapsulation of essential oils. Polymeric particles were developed to encapsulate the essential oil from Piper nigrum based on gelatin and poly-ε-caprolactone (PCL) carriers. Gas Chromatography ((Flame Ionization Detection (GC/FID) and Mass Spectrometry (GC/MS)), Atomic Force Microscopy (AFM), Nanoparticle Tracking Analysis (NTA), Confocal Laser Scanning Microscopy (CLSM), Attenuated Total Reflectance-Fourier-transform Infrared ...
Tópico(s): Olfactory and Sensory Function Studies
2022 - Multidisciplinary Digital Publishing Institute | Materials
Produção Nacional
Revisado por pares
Ywlliane da Silva Rodrigues Meurer, Sara Sophia Guedes Linhares, Alvaro C. Lima, Antônio Carlos Queiroz de Aquino, Luiz Eduardo Mateus Brandão, Diana Aline Nôga, Clarissa Loureiro das Chagas Campêlo, Ramón Hypolito Lima, Jeferson S. Cavalcante, Rovena Clara Galvão Januário Engelberth, Alessandra Mussi Ribeiro, Regina H. Silva,
The exposure to selective serotonin reuptake inhibitors (SSRIs) during development results in behavioural impairment in adulthood in humans and animal models. Indeed, serotonergic overexpression in early life leads to structural and functional changes in brain circuits that control cognition and emotion. However, the effects of developmental exposure to these substances on the behaviour of adolescent rats are conflicting and remain poorly characterised. We performed a behavioural screening to investigate ...
Tópico(s): Tryptophan and brain disorders
2021 - Wiley | International Journal of Developmental Neuroscience
Produção Nacional
Revisado por pares
Mariana de Souza, Josias Martins dos Anjos Cruz, Renilto Frota Corrêa, Carlos Victor Lamarão, Alessandra Ramos Lima, Natália Mayumi Inada, Edgar Aparecido Sanches, Jaqueline de Araújo Bezerra, Pedro Henrique Campelo,
The Amazon region has a significant biodiversity composed of several fruits with health benefits and distinguished potential for technological application and development of novel products. Buriti (Mauritia flexuosa) is one of the main Amazonian fruits with expressive nutraceutical properties. For this reason, this review aims to elucidate the current state of knowledge on buriti, providing information on its bioactive compounds, nutraceutical, and health potential for both technological and economic ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2022 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Alessandra Paula Carvalho, Lauren Christine Gursky, Rosimeire Takaki Rosa, Alinne Ulbrich Mores Rymovicz, Patrícia Maria Stuelp Campelo, Ana Maria Trindade Grégio, Cristiane Yumi Koga‐Ito, Lakshman P. Samaranayake, Edvaldo Antônio Ribeiro Rosa,
The phenotypic pressure exerted by non-steroidal anti-inflammatory drugs (NSAIDs) on autochthonous and pathogenic microbiota remains sparsely known. In this study, we investigated if some NSAIDs increment or diminish the secretion of aspartyl-proteases (Sap) by Candida albicans grown under different phenotypes and oxygen availability using a set of SAP knock-out mutants and other set for genes (EFG1 and CPH1) that codify transcription factors involved in filamentation and protease secretion. Pre-conditioned ...
Tópico(s): Drug-Induced Adverse Reactions
2010 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Luiz Eduardo Mateus Brandão, Diana Aline Nôga, Aline Lima Dierschnabel, Clarissa Loureiro das Chagas Campêlo, Ywlliane da Silva Rodrigues Meurer, Ramón Hypolito Lima, Rovena Clara Galvão Januário Engelberth, Jeferson S. Cavalcante, Clésio Andrade Lima, Murilo Marchioro, Charles dos Santos Estevam, José R. Santos, Regina H. Silva, Alessandra Mussi Ribeiro,
Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract ( ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2017 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine
Alessandra Bearz, Jean‐François Martini, Jacek Jassem, Sang‐We Kim, Gee‐Chen Chang, Alice T. Shaw, D A Shepard, E. Dall’O’, Anna Polli, Holger Thurm, Gérard Zalcman, M.R. García Campelo, Konstantin Penkov, Hidetoshi Hayashi, Benjamin Solomon,
IntroductionLorlatinib, a third-generation ALK tyrosine kinase inhibitor, improved outcomes compared with crizotinib in patients with previously untreated ALK-positive advanced NSCLC in the phase 3 CROWN study. Here, we investigated response correlates using plasma circulating tumor DNA (ctDNA) and tumor tissue profiling.MethodsALK fusions and ALK with or without TP53 mutations were assessed by next-generation sequencing. End points included objective response rate (ORR), duration of response, and ...
Tópico(s): Genetic factors in colorectal cancer
2023 - Elsevier BV | Journal of Thoracic Oncology
Sanjay Popat, Alessandra Curioni‐Fontecedro, Varvara Polydoropoulou, Riyaz Shah, Mary O’Brien, A. Pope, P.M. Fisher, James Spicer, A. Roy, D. Gilligan, Oliver Gautschi, Ernest Nadal, Wolf-Dieter Janthur, Rafael López Castro, Rosario García Campelo, Heidi Roschitzki‐Voser, Barbara Ruepp, Sylvie Rusakiewicz, Solange Peters, Rolf A. Stahel,
Abstract Background MPM is an aggressive malignancy of increasing prevalence and poor prognosis. At relapse after platinum-based (pb) CT, single agent CT is commonly used and single arm trials of immune checkpoint inhibitors have demonstrated encouraging activity. Methods PROMISE-meso is an open-label 1:1 randomized phase III trial investigating the efficacy of P (200 mg/Q3W) vs institutional choice single agent CT (gemcitabine or vinorelbine) in relapsed MPM patients (pts) failing one previous line ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2019 - Elsevier BV | Annals of Oncology
Sanjay Popat, Alessandra Curioni‐Fontecedro, Urania Dafni, R. Shah, Mary O’Brien, A. Pope, P.M. Fisher, James Spicer, A. Roy, D. Gilligan, Oliver Gautschi, Ernest Nadal, Wolf-Dieter Janthur, Rafael López Castro, Rosario García Campelo, Sylvie Rusakiewicz, Igor Letovanec, Varvara Polydoropoulou, Heidi Roschitzki‐Voser, Barbara Ruepp, A. Gasca-Ruchti, Solange Peters, Rolf A. Stahel,
•First randomised, controlled trial evaluating efficacy of an anti-PD1 agent versus chemotherapy in relapsed MPM, with immunotherapy crossover allowed.•Objective response rate was significantly improved for pembrolizumab (22% versus 6%, P = 0.004).•No improvement for independently reviewed PFS for pembrolizumab over chemotherapy (HR = 1.06, 95% CI: 0.73–1.53, P = 0.76).•No overall survival improvement for pembrolizumab over chemotherapy (HR = 1.04, 95% CI: 0.66–1.67, P = 0.85). BackgroundMalignant pleural mesothelioma ( ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2020 - Elsevier BV | Annals of Oncology
Produção Nacional
Revisado por pares
Antonio Passaro, Jing Wang, Yan Wang, S.-H. Lee, Barbara Melosky, Jin‐Yuan Shih, Jing Wang, K. Azuma, Óscar Juan, Manuel Cobo, Enriqueta Felip, Nicolas Girard, Alexis B. Cortot, Raffaele Califano, Federico Cappuzzo, Scott Owen, Sanjay Popat, Ju Le Tan, Jorge Salinas, Pascale Tomasini, Ryan D. Gentzler, William N. William, Karen L. Reckamp, Toshiaki Takahashi, Sandip Ganguly, Dariusz M. Kowalski, Alessandra Bearz, Melanie Mackean, P. Barala, Ariel B. Bourla, Angela Girvin, James Greger, Dawn Millington, M. Withelder, John Xie, Tao Sun, Shalin Shah, B. Diorio, R.E. Knoblauch, Joshua Bauml, Rosario García Campelo, Byoung Chul Cho,
Amivantamab plus carboplatin-pemetrexed (chemotherapy) with and without lazertinib demonstrated antitumor activity in patients with refractory epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) in phase I studies. These combinations were evaluated in a global phase III trial.
Tópico(s): Cancer therapeutics and mechanisms
2023 - Elsevier BV | Annals of Oncology
D. Ross Camidge, Hye Ryun Kim, Myung‐Ju Ahn, James Chih‐Hsin Yang, Han Jin, J. Lee, Maximilian J. Hochmair, Jacky Yu-Chung. Li, Gee‐Chen Chang, Kyoung Bun Lee, Cesare Gridelli, Angelo Delmonte, M.R. García Campelo, D. Kim, Alessandra Bearz, Frank Griesinger, Alessandro Morabito, Enriqueta Felip, Raffaele Califano, Samit Ghosh, Alexander I. Spira, Scott Gettinger, Marcello Tiseo, J. Haney, David Kerstein, Sanjay Popat,
Brigatinib has robust efficacy in crizotinib-resistant ALK+ NSCLC, exhibiting median progression-free survival (mPFS) of 16.7 months. We report results of the first interim analysis from the ALTA-1L study of brigatinib vs crizotinib in ALK TKI-naive, ALK+ NSCLC (NCT02737501). This open-label, multicenter study enrolled patients with stage IIIB/IV ALK+ NSCLC based on local ALK testing (FDA approved/other). Eligible patients had ECOG PS 0–2, ≤1 prior systemic therapy for locally advanced/metastatic NSCLC, ...
Tópico(s): Colorectal Cancer Treatments and Studies
2018 - Elsevier BV | Journal of Thoracic Oncology
Alexandre Marques da Rocha, M. Campelo, Bruna Lisboa Nunes, Emilly Alessandra Cruz dos Reis, Cléa Nazaré Carneiro Bichara,
Objetivo: Analisar a correlação espacial das taxas de incidência de Zika vírus (ZV) nos municípios do Pará com os fatores sociodemográficos e econômicos da região. Métodos: É um estudo ecológico, utilizando dados do Departamento de Informática do Sistema Único de Saúde (DATASUS). Os índices de Moran (IM) global univariados foram acessados para a análise da correlação espacial das taxas de incidência de ZV, e os bivariados para análise dos fatores sociodemográficos relacionados. A partir dos dados significativos ( ...
Tópico(s): Mosquito-borne diseases and control
2024 - | Revista Eletrônica Acervo Científico
Maria Lúcia Gomes Ferraz, EVELYN KAILANNY CAMPELO DE OLIVEIRA, R.M. Perez, Alessandra Dellavance, L.E. Andrade, Valéria Pereira Lanzoni,
Tópico(s): Liver Diseases and Immunity
2017 - Elsevier BV | Journal of Hepatology
Maria Clara Viégas Campelo, Sávio Roberto Silva Costa, Emilly Alessandra Cruz dos Reis, Fernando Gabriel Rodrigues Pereira, Natália Kiss Nogueira da Silva,
Introdução: O transtorno depressivo maior (TDM) é caracterizado por tristeza persistente e falta de interesse/prazer em atividades e que afeta cerca de 10,2% dos adultos no Brasil. A estimulação magnética transcraniana (EMT) vem ganhando notoriedade em relação ao tratamento da depressão. Assim, o estudo possui o objetivo de realizar uma revisão sobre as experiências relacionadas a utilização da EMT como tratamento do TDM no Brasil. Metodologia: O estudo é uma revisão sistemática da literatura. As ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2024 - Brazilian Journal of Development | Brazilian Journal of Health Review
Clarissa Rosa, Bruno R. Ribeiro, Vanesa Bejarano Alegre, Fernando Henrique Puertas, Adriana Bocchiglieri, Adriana Loeser dos Santos Barbosa, Adriano G. Chiarello, Adriano Pereira Paglia, Adriele Aparecida Pereira, Adryelle Francisca de Souza Moreira, Agnis Cristiane de Souza, A. O. Pellegrin, Ailín Gatica, Akyllan Zoppi Medeiro, Alan Deivid Pereira, Alan Gerhardt Braz, Alberto Yanosky, Alejandro E. J. Valenzuela, Alessandra Bertassoni, Alessandra dos Santos Venturini do Prado, Alessandra Ferreira Dales Nava, Alessandro Rocha, Alex Augusto Abreu Bovo, Alex Bager, Alexandra Cravino, Alexandra S. Pires, Alexandre Camargo Martensen, Alexandre Filippini, Alexandre Reis Percequillo, Alexandre Vogliotti, Alexsander Zamorano Antunes, Aline Cristina Leite de Oliveira, Allan Jefferson da Silva de Oliveira, Allison L. Devlin, Almir de Paula, Aluane Silva Ferreira, Alvaro García‐Olaechea, Amanda L. Subalusky, Amadeo Sánchez, Ana Carla Medeiros Morato de Aquino, Ana Carolina Srbek‐Araujo, Amane Paldês Gonçales, Ana Caroline L. Araújo, A. Cecilia Gozzi, Ana Cecilia Ochoa, Ana Cristina Mendes de Oliveira, Ana Cristyna Reis Lacerda, Ana Karina de Francisco, Ana Maria de Oliveira Paschoal, Ana Paula Nascimento Gomes, Ana Paula Potrich, Ana Priscila Medeiros Olímpio, Ana Pozuelos Rojas, Ana Yoko Ykeuti Meiga, Anah Tereza de Almeida Jácomo, Analice Maria Calaça, Anderson Feijó, Anderson Pagoto, André Sebastián Borja-Chiriboga, André Chein Alonso, André Felipe Barreto‐Lima, André Monnerat Lanna, André Luís Luza, André Restel Camilo, André Tavares, André Valle Nunes, Andreas Kindel, Andrés de Miguel, Andressa Gatti, Andrezza Bellotto Nobre, Anielise da Conceição Campêlo, Anna Carolina Figueiredo de Albuquerque, J. Antonio de la Torre, Antonio M. Mangione, Antônio Rossano Mendes Pontes, Arthur Soares Fernandes, Artur Luiz de Almeida Felício, Átilla Colombo Ferreguetti, Arlei Marcili, Augusto João Piratelli, Ariel Guilherme Santos do Nascimento, Áureo Banhos, Beatris Felipe Rosa, Beatriz Azevedo Cezila, Benoı̂t de Thoisy, Bianca Ingberman, Bianca Köhler, Bianca Cruz Morais, Bibiana Gómez‐Valencia, Bruna Bertagni de Camargo, Bruna M. Bezerra, Bruna Tamasauskas, Bruno Augusto Torres Parahyba Campos, Bruno Busnello Kubiak, Bruno H. Saranholi, Bruno Kazuo Nakagawa, Bruno Leles, Burton K. Lim, Calebe Pereira Mendes, Camila Alvez Islas, Camila Aoki, Camila Cantagallo Devids, Camila Pugliesi De Figueiredo, Camila Matias Goes de Abreu, Camila Raquel Silva Oliveira, Camila Righetto Cassano, Camile Lugarini, Carin Caputo, Carla C. Gestich, Carla Denise Tedesco, Carla Fabiane de Vera y Conde, Carla Grasiele Zanin Hegel, Carlos Benhur Kasper, Carlos De Angelo, Carlos Eduardo Viveiros Grelle, Carlos Eduardo Fragoso, Carlos Eduardo Lustosa Esbérard, Carlos Frederico Duarte Rocha, Carlos Eduardo Verona, Carlos Henrique Salvador, Carlos Leonardo Vieira, Carlos Roberto Abrahão, Carlos Rodrigo Brocardo, Carolline Zatta Fieker, Caryne Braga, Catalina Sánchez‐Lalinde, Cecília Bueno, Cássia Yumi Ikuta, Cecília Licarião Luna, César Cestári, Christine Del Vechio Koike, Christoph Knogge, Christopher B. Anderson, Cindy M. Hurtado, Cintia Ferreira Antunes de Oliveira, Cintia Gisele Tellaeche, Clarice Silva Cesário, Claudia Guimarães Costa, Claudia Zukeran Kanda, Sebastián Andrés Costa, Cristiana Simão Seixas, Cristiano Trapé Trinca, Cristina Fabiola López‐Fuerte, Cristina Jaques da Cunha, Cynthia Doutel Ribas, Cyntia Cavalcante Santos, Daiane Buscariol, Daiane Carreira, Daiane Chaves do Nascimento, Danianderson Rodrigues Carvalho, Daniel da Silva Ferraz, Daniel Galiano, Daniel Henrique Homem, Daniel Jesús‐Espinosa, Daniela Aparecida Savariz Bôlla, Daniele Janina Moreno, Danielle de Oliveira Moreira, Danielle Leal Ramos, Danilo Angelucci de Amorim, Darci Moraes Barros‐Battesti, David Echeverri Lopez, Davi Castro Tavares, David M. Post, Dayvid Rodrigues Couto, Dennis Nogarolli Patrocínio, Diana Letícia Kruger Pacheco Carvalho, Diego Afonso Silva, Diego Córdoba, Diego Queirolo, Diego� Varela, Dilmar Alberto Gonçalves de Oliveira, Diogo Cavenague Casanova, Douglas de Matos Dias, Douglas Machado da Silva, Eder Barbier, Edgar Federico Rivadeneira, Eduardo Roberto Alexandrino, Eduardo Carrano, Eduardo Marques Santos, Eduardo Martins Venticinque, Edwin L. Hernández-Pérez, Egberto da Fonseca Casazza, Elizabeth P. Anderson, Elmary da Costa Fraga, Elson Fernandes de Lima, Elvira D’Bastiani, Emerson Monteiro Vieira, Emiliano Guijosa‐Guadarrama, Enrique M. González, Erica Vanessa Maggiorini, Erick Francisco Silva de Aguiar, Erik Daniel Martínez‐Nambo, Érika Paula Castro, Erika de la Peña‐Cuéllar, Ezequiel Pedó, Fabiana Cristina Silveira Alves de Melo, Fabiana Lopes Rocha, Fabiana Luques Fonseca, Fabiane Girardi, Fabiano Rodrigues de Melo, Fábio de Oliveira Roque, Fabíola Keesen, Felipe Bortolotto Peters, Felipe Moreli Fantacini, Felipe Pedrosa, Felipe Pessoa da Silva, Felipe Vélez‐García, Fernanda Delborgo Abra, Fernanda Cavalcanti de Azevedo, Fernanda Guedes da Silva, Fernanda Maria Neri, Fernanda Zimmermann Teixeira, Fernando Antonio dos Santos Fernandez, Fernando Carvalho, Fernandode Camargo Passos, Fernando de Castro Jacinavicius, Fernando Ferreira, Fernando Ferreira de Pinho, Fernando Gonçalves, Fernando Ibanez Martins, Fernando Lima, Fernando M. Contreras‐Moreno, Fernando Silvério Ribeiro, Fernando Rodrigo Tortato, F.M.PATEL F.M.PATEL, Flavia Caruso, Flávia Pereira Tirelli, Flávio Henrique Guimarães Rodrigues, Flávio Kulaif Ubaid, Francesca Belem Lopes Palmeira, Francisco Grotta‐Neto, Francisco Homem Gabriel, Franco L. Souza, Francys E. da Veiga da Costa, Gabriel Lima Aguiar, Frederico Gemesio Lemos, Gabriel Shimokawa Magezi, Gabriel Ferreira Vianna Di Panigai, Gabriel Selbach Hofmann, Gabriela Heliodoro, Gabriela Rosa Graviola, Gabrielle Beca, Gabrielle Ribeiro de Andrade, Germán Jiménez, Gabriela Teixeira Duarte, Geruza Leal Melo, Geverson Luiz Dierings, Gilberto Sabino‐Santos, Geovana Linhares de Oliveira, Gindomar Gomes Santana, Giordano Ciocheti, Gisele Lamberti Zanirato, Giselle Bastos Alves, Graziele Oliveira Batista, Greici Maia Behling, Guilherme Braga Ferreira, Guilherme Casoni da Rocha, Gisele Lessa, Guilherme Mourão, Gustavo A. Marás, Gustavo Alves da Costa Toledo, Gustavo Gonsioroski, Gustavo Rodrigues Canale, Karl‐Ludwig Schuchmann, Harley Sebastião, Helena Alves do Prado, Helena Godoy Bergallo, Helio Secco, Henrique Llacer Roig, Henrique Rajão, Henrique Santiago Alberto Carlos, Herbert O. B. Duarte, Hiago Ermenegildo, Hilda Fátima Jesus Pena, Hilton Entringer, Hipólito Ferreira Paulino Neto, Hudson de Macedo Lemos, Hugo del Castillo, Hugo Fernandes‐Ferreira, Hugo Ignacio Coitiño Banquero, Ignacio Roesler, Igor Kintopp Ribeiro, Igor Pfeifer Coelho, Ingrid M. S. Lima, Isabel Muniz Bechara, Isabel Salgueiro Lermen, Isac Mella-Méndez, Gabriela Schuck, Isadora Beraldi Esperandio, Ita de Oliveria Silva, Ítalo Mourthé, Igor Oliveira, Itiberê P. Bernardi, Jacqueline R. Miller, Jader Marinho‐Filho, Jairo José Zocche,
Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or ...
Wiley