Stefano Négrini, Sabrina Donzelli, Alberto Negrini, Alessandra Negrini, Michele Romano, Zaina Fabio,
To investigate the feasibility and acceptability of telemedicine as a substitute for outpatient services in emergency situations such as the sudden surge of the COVID-19 pandemic in Italy.Observational cohort study with historical control.Tertiary referral outpatient institute.Consecutive services provided to patients with spinal disorders (N=1207).Telemedicine services included teleconsultations and telephysiotherapy, and lasted as long as usual interventions. They were delivered using free teleconference ...
Tópico(s): COVID-19 and Mental Health
2020 - Elsevier BV | Archives of Physical Medicine and Rehabilitation
Stefano Négrini, Sabrina Donzelli, Alessandra Negrini, Silvana Parzini, Michele Romano, Fabio Zaina,
In an ideal experimental setting, 2 randomized controlled trials recently showed the efficacy of physiotherapeutic scoliosis-specific exercises (PSSEs) for adolescents with idiopathic scoliosis (AIS). Now large observational studies are needed to check the generalizability of these results to everyday clinical life. To explore the effectiveness of PSSEs for avoiding bracing or progression of AIS in everyday clinics. This was a longitudinal comparative observational multicenter study, nested in a prospective ...
Tópico(s): Pelvic and Acetabular Injuries
2018 - Elsevier BV | Annals of Physical and Rehabilitation Medicine
Grazia Maria Spaggiari, Paola Contini, Simone Negrini, Alessandra Dondero, Roberta Carosio, Massimo Ghio, Francesco Puppo, Francesco Indiveri, Maria Raffaella Zocchi, Alessandro Poggi,
Abstract The engagement of CD8 on NK cell surface by either surface or soluble HLA class I (sHLA‐I) molecules induces synthesis and secretion of IFN‐γ. HLA‐I‐mediated effects were inhibited by the covering of CD8 with specific anti‐CD8 monoclonal antibodies, indicating a direct interaction of HLA‐I and CD8. That CD8 ligation induces IFN‐γ production was further supported by the finding that cross‐linking of CD8 led to release of IFN‐γ at similar levels to those obtained with HLA‐I. The sHLA‐I‐induced ...
Tópico(s): Reproductive System and Pregnancy
2003 - Wiley | European Journal of Immunology
Stefano Négrini, Fabio Zaina, Michele Romano, Alessandra Negrini, Silvana Parzini,
Objective: To compare the effect of Scientific Exercises Approach to Scoliosis (SEAS) exercises with "usual care" rehabilitation programmes in terms of the avoidance of brace prescription and prevention of curve progression in adolescent idiopathic scoliosis.Design: Prospective controlled cohort observational study.Patients: Seventy-four consecutive outpatients with adolescent idiopathic scoliosis, mean 15° (standard deviation 6) Cobb angle, 12.4 (standard deviation 2.2) years old, at risk of bracing ...
Tópico(s): Hip disorders and treatments
2008 - Foundation for Rehabilitation Information | Journal of Rehabilitation Medicine
Fabio Zaina, Stefano Négrini, Salvatore Atanasio, Claudia Fusco, Michele Romano, Alessandra Negrini,
Exercises are frequently performed in order to improve the efficacy of bracing and avoid its collateral effects. Very frequently there is a loss of correction during brace weaning in AIS treatment.To verify the efficacy of exercises in reducing correction loss during brace weaning.Retrospective controlled study.Sixty-eight consecutive patients (eight males), age 15 +/- 1 and Cobb angle 22 +/- 8 degrees at start of brace weaning.The start of brace weaning was defined as the first visit in which the wearing ...
Tópico(s): Pelvic and Acetabular Injuries
2009 - BioMed Central | Scoliosis
Michele Romano, Alessandra Negrini, Silvana Parzini, Marta Tavernaro, Fabio Zaina, Sabrina Donzelli, Stefano Négrini,
SEAS is the acronym for "Scientific Exercise Approach to Scoliosis", a name related to the continuous changes of the approach based on results published in the literature.SEAS is an individualized exercise program adapted to all situations of conservative treatment of scoliosis: stand-alone in low-medium degree curves during growth to reduce the risk of bracing; complimentary to bracing in medium-high degree curves during growth, with the aim to increase correction, prepare weaning, and avoid/reduce ...
Tópico(s): Cerebral Palsy and Movement Disorders
2015 - BioMed Central | Scoliosis
Alessandra Negrini, Maria Gabriella Negrini, Sabrina Donzelli, Michele Romano, Fabio Zaina, Stefano Négrini,
Scoliosis fusion surgery is generally considered the only means to stop the progression of adult idiopathic scoliosis (ADIS), but for patients refusing surgery there is lack of evidence in favour of conservative treatment. The aim of the present study was to verify the possible effectiveness of scoliosis-specific exercises when facing ADIS progression.We designed a retrospective cohort study. We included 34 ADIS patients in treatment at our Institute (5 males and 29 females, mean age was 38.0 ± 11.0), ...
Tópico(s): Pelvic and Acetabular Injuries
2015 - BioMed Central | Scoliosis
Michele Romano, Alessandra Negrini, Silvana Parzini, Sabrina Donzelli, Fabio Zaina, Stefano Négrini,
Purpose/backgroundUsually scoliosis between 10°and 20°are not treated: in some Centres conservative preventive treatment is provided [1][2].Aim of this study is to compare results of different type of treatments.
Tópico(s): Scoliosis diagnosis and treatment
2012 - BioMed Central | Scoliosis
Carlo Fusco, Fabio Zaina, Salvatore Atanasio, Michele Romano, Alessandra Negrini, Stefano Négrini,
Two years ago we published an update of another of our previous systematic reviews about the effectiveness of physical exercises (PEs), and we found that the evidence on exercises for AIS was of level 1b. Now we have updated these results in the field of exercises for AIS with the final aim to find the strongest evidence as possible about PEs. Our goal was to verify if treatment with specific exercises for AIS has changed in these years. The study design was a systematic review. A bibliographic search ...
Tópico(s): Myofascial pain diagnosis and treatment
2011 - Taylor & Francis | Physiotherapy Theory and Practice
Alessandra Negrini, Silvana Parzini, Maria Gabriella Negrini, Michele Romano, Salvatore Atanasio, Fabio Zaina, Stefano Négrini,
It has been known since many years that scoliosis can continue to progress after skeletal maturity: the rate of progression has shown to be linear, and it can be used to establish an individual prognosis. Once there is progression there is an indication for treatment: usually it is proposed a surgical one. There are very few papers on an alternative rehabilitation approach; since many years we propose specific SEAS exercises and the aim of this study is to present one case report on this approach. ...
Tópico(s): Pelvic and Acetabular Injuries
2008 - BioMed Central | Scoliosis
Alessandra Negrini, Massimiliano Vanossi, Sabrina Donzelli, Fabio Zaina, Michele Romano, Stefano Négrini,
Plumb line distances (PDs) are widely used in conservative clinical practice to evaluate the sagittal shape of the spine.The objective was to assess the normative values of PDs in a large, healthy population in an age range representative of the adolescent population with spinal deformities, and to correlate it with x-ray measurements.This was a cross-sectional study.Participants were 584 healthy individuals (341 females) with x-rays showing no spine deformities. The whole sample (OVERALL) was divided ...
Tópico(s): Spine and Intervertebral Disc Pathology
2019 - Oxford University Press | Physical Therapy
Massimo Ghio, Paola Contini, Simone Negrini, Silvia Boero, Alessandra Musso, Alessandro Poggi,
Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clones secreted TGF-beta1 upon the interaction of sHLA-I with CD8 molecule. sHLA-Cw4 or sHLA-Cw3 alleles engaging inhibitory isoforms of KIR, namely KIR2DL1 or KIR2DL2, strongly downregulated ...
Tópico(s): CAR-T cell therapy research
2009 - Wiley | European Journal of Immunology
Leanom Johnson, Fiona M. Asigbee, R. Crowell, Alessandra Negrini,
Using a novel qualitative approach, Photovoice, researchers assessed social, psychological, physical and economic barriers encountered by patients of weight loss surgery. Applying the Photovoice approach and Williams' theory of narrative reconstruction for qualitative interviewing, the research team set out to investigate the bariatric patient experience from pre-surgery to hospitalization to post-surgery. Fifteen participants were given digital cameras and asked to take photographs that represented ...
Tópico(s): Body Contouring and Surgery
2018 - Wiley | Clinical Obesity
Nadia Felli, Federica Felicetti, Anna Maria Lustri, Maria Cristina Errico, Lisabianca Bottero, Alessio Cannistraci, Alessandra De Feo, Marina Petrini, Francesca Pedini, Mauro Biffoni, Ester Alvino, Massimo Negrini, Manuela Ferracin, Gianfranco Mattia, Alessandra Carè,
The abnormal expression of several microRNAs has a causal role in tumorigenesis with either antineoplastic or oncogenic functions. Here we demonstrated that miR-126 and miR-126* play a tumor suppressor role in human melanoma through the direct or indirect repression of several key oncogenic molecules. The expression levels of miR-126&126* were elevated in normal melanocytes and primary melanoma cell lines, whereas they markedly declined in metastatic cells. Indeed, the restored expression of miR- ...
Tópico(s): Circular RNAs in diseases
2013 - Public Library of Science | PLoS ONE
Sebastiano Mura, Glenda Giorgia Caputo, Giovanni Miotti, Filippo Contessi Negrini, Alessandra Fin, Emanuele Rampino Cordaro, Gianni Franco Guarneri, Chiara Zanin, Matteo D’Angelo, Annarita Tullio, Pier Camillo Parodi,
... by this authorFilippo Contessi Negrini MD, Filippo Contessi Negrini MD DAME (Department of Medical Area), Plastic and Reconstructive Surgery, Academic Hospital of Udine, Udine, ItalySearch for more papers by this authorAlessandra Fin MD, Alessandra Fin MD DAME (Department of Medical Area), Plastic ... by this authorFilippo Contessi Negrini MD, Filippo Contessi Negrini MD DAME (Department of Medical Area), Plastic and Reconstructive Surgery, Academic Hospital of Udine, Udine, ItalySearch for more papers by this authorAlessandra Fin MD, Alessandra Fin MD DAME (Department of Medical Area), Plastic ...
Tópico(s): Reconstructive Facial Surgery Techniques
2021 - Wiley | The Breast Journal
Lorenzo Bomba, Ezequiel Luís Nicolazzi, Marco Milanesi, Riccardo Negrini, Giordano Mancini, Filippo Biscarini, Alessandra Stella, Alessio Valentini, Paolo Ajmone‐Marsan,
A number of methods are available to scan a genome for selection signatures by evaluating patterns of diversity within and between breeds. Among these, "extended haplotype homozygosity" (EHH) is a reliable approach to detect genome regions under recent selective pressure. The objective of this study was to use this approach to identify regions that are under recent positive selection and shared by the most representative Italian dairy and beef cattle breeds. A total of 3220 animals from Italian Holstein ( ...
Tópico(s): Animal Genetics and Reproduction
2015 - BioMed Central | Genetics Selection Evolution
Alessandra Negrini, Martina Poggio, Sabrina Donzelli, Massimiliano Vanossi, Claudio Cordani, Michele Romano, Stefano Négrini,
The association between idiopathic scoliosis (IS) and sports activities remains vague. We aimed to analyse their effect on full-time braced adolescents with IS.We retrospectively recruited all the consecutive patients of a tertiary referral Institute of age ≥ 10 (adolescents), with a juvenile (JIS) or adolescent (AIS) IS diagnosis, Risser 0-2, TLSO brace prescription and self-reported adherence ≥ 20 h per day, and follow-up out-of-brace X-rays 18 months after brace prescription. We divided participants ...
Tópico(s): Pelvic and Acetabular Injuries
2022 - Springer Science+Business Media | European Spine Journal
Stefano Négrini, Michele Romano, Alessandra Negrini, Silvana Parzini,
Study design All fifty-eight patients (17% male, 83% female) who finished their treatment in the Centre of Vigevano of our Institute were included. Mean Cobb angle at the start of treatment was 22.6 ± 10.6 degrees (see Table 1), and mean age was 13.4 ± 2.4 years. Treatment groups considered included exercises, bracing+exercises, cast+exercises. Starting Cobb degrees, by groups, were: 11–20, 21–30, 31–40, over 40 degrees (see Table 2).
Tópico(s): Meta-analysis and systematic reviews
2007 - BioMed Central | Scoliosis
Michele Romano, Stefano Négrini, Fabio Zaina, Alessandra Negrini, Silvana Parzini,
After documenting the short term higher efficacy of SEAS.02 (Scientific Exercises Approach to Scoliosis, version 2002) versus classical physiotherapy [1], with this study we aim at verifying it in a longer term.
Tópico(s): Spinal Fractures and Fixation Techniques
2007 - BioMed Central | Scoliosis
Manuela Ferracin, Laura Lupini, Alessandra Mangolini, Massimo Negrini,
Recent studies suggested that colorectal cancer influences the types and quantity of nucleic acids - especially microRNAs – detected in the bloodstream. Concentration of circulating (cell-free) microRNAs, and possibly of other non-coding RNAs, could therefore serve as valuable colorectal cancer biomarker and could deliver insight into the disease process. This chapter addresses the recent discoveries on circulating microRNA and long non-coding RNA as diagnostic or prognostic biomarkers in colorectal ...
Tópico(s): Circular RNAs in diseases
2016 - Springer Nature | Advances in experimental medicine and biology
Manuela Sarti, Cinzia Sevignani, George A. Calin, Rami I. Aqeilan, Masayoshi Shimizu, Francesca Pentimalli, Maria Cristina Picchio, Andrew K. Godwin, Anne Rosenberg, Alessandra Drusco, Massimo Negrini, Carlo M. Croce,
The human TESTIN (TES) gene is a putative tumor suppressor gene in the fragile chromosomal region FRA7G at 7q31.1/2 that was reported to be altered in leukemia and lymphoma cell lines. In this report, we investigated the effect of TES gene expression in vivo to evaluate a possible role of TES gene in human cancer.We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. Furthermore, to evaluate the potential of TES gene therapy, ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2005 - American Association for Cancer Research | Clinical Cancer Research
Alessandra Celletti, P. Negrini,
Tópico(s): Advanced Differential Equations and Dynamical Systems
1995 - Springer Science+Business Media | Celestial Mechanics and Dynamical Astronomy
Giorgio Zauli, Davide Gibellini, Antonella Caputo, Alessandra Bassini, Massimo Negrini, Maria Monne, Maria Rosa Mazzoni, Silvano Capitani,
The regulatory Tat protein of human immunodeficiency virus type-1 (HIV- 1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Stable and transient transfections of Jurkat cells with the cDNA of tat and a plasmid containing Bcl-2 promoter in front ...
Tópico(s): Virology and Viral Diseases
1995 - Elsevier BV | Blood
Bianca Clerici, Mariangela Scavone, Simone Birocchi, Chiara Aloise, Benedetta Peroni, A Negrini, Claudia Ghali, Giovanni Casazza, Gian Marco Podda,
... Birocchi. Benedetta Peroni, Chiara Aloise, Claudia Ghali and Alessandra Negrini performed data extraction and contributed to data analysis. ... Clerici, Mariangela Scavone, Benedetta Peroni, Chiara Aloise and Alessandra Negrini. Giovanni Casazza supervised the statistical approach and critically ...
Tópico(s): Intramuscular injections and effects
2023 - Wiley | British Journal of Haematology
Produção Nacional
... do tableau, o filme coloca o corpo de Alessandra Negrini no centro do enquadramento a recriar a famosa ...
Tópico(s): Literature, Culture, and Criticism
2019 - | Revista ECO-Pós
Produção Nacional
Eliandro Rodrigues Cirilo, Alessandra Negrini Dalla Barba, Paulo Laerte Natti, Neyva Maria Lopes Romeiro,
In this paper we developed a numerical methodology to study some incompressible fluid flows without free surface, using the curvilinear coordinate system and whose edge geometry is constructed via parametrized spline. First, we discussed the representation of the Navier-Stokes and continuity equations on the curvilinear coordinate system, along with the auxiliary conditions. Then, we presented the numerical method – a simplified version of MAC (Marker and Cell) method – along with the discretization ...
Tópico(s): Computational Fluid Dynamics and Aerodynamics
2018 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Exatas e Tecnológicas
Alessandra Negrini, Sabrina Donzelli, Monia Lusini, Salvatore Minnella, Fabio Zaina, Stefano Négrini,
Methods Setting. Outpatient tertiary referral clinic. Population. Out of 778 patients, 246 fulfilled the inclusion criteria: Idiopathic Scoliosis; first brace prescription; regular use of Thermobrace heat sensor; two evaluations after bracing; age 36; European Risser 0-3. Evaluations. T0 (start of bracing), T1 (4 months), T2 (10 months). Measurements. Brace wearing compliance (BWC) T0 to T1 (T0-T1) and T1 to T2 (T1-T2). Treatment. CBA adjunctive sessions dispensed during PSSE (CBA-PSSE), after the standard ...
Tópico(s): Spinal Fractures and Fixation Techniques
2014 - BioMed Central | Scoliosis
Paolo Pizzetti, Michele Romano, Alessandra Negrini, Stefano Négrini,
SOSORT Consensus Conference (Milan 2005) developed about the main important features of a correct treatment based on physical exercises states that the main point is self correction. The SEAS school of treatment focuses on Active Self Correction (ASC) that is the series of movements of reallignemnt as a whole that the patients autonomously performs in order to reduce the scoliotic curves. This movement has to be performed as much as possible in three dimension so the ASC movement sometimes is not ...
Tópico(s): Motor Control and Adaptation
2010 - BioMed Central | Scoliosis
Alessandra Negrini, Sabrina Donzelli, Michele Romano, Fabio Zaina, Stefano Négrini,
Negrini, Alessandra; Donzelli, Sabrina; Romano, Michele; Zaina, Fabio; Negrini, Stefano Author Information
Tópico(s): Infrared Thermography in Medicine
2020 - Lippincott Williams & Wilkins | Prosthetics and Orthotics International
Stefano Négrini, Sabrina Donzelli, Alessandra Negrini, Silvana Parzini, Michele Romano, Fabio Zaina,
Methods Setting: outpatient tertiary referral clinics. Participants: consecutive patients from start of the database to 31/12/2010. Inclusion criteria: IS; Risser 0-2; 11° to 20° Cobb; age 10 years or more; first evaluation. Exclusion criteria: consultations only; immediate prescription of a brace. Groups: Physiotherapic Specific Scoliosis Exercises SEAS school (PSSE: at least 45 min/week, 3 cognitivebehavioral sessions/year); Controls (CON: less than 15 min/week); Usual Physiotherapy (UP: other institutes/ ...
Tópico(s): Shoulder Injury and Treatment
2014 - BioMed Central | Scoliosis