Monica Marzagalli, Giorgia Pelizzoni, Arianna Fedi, Chiara Vitale, Fabrizio Fontana, Silvia Bruno, Alessandro Poggi, Alessandra Dondero, Maurizio Aiello, Roberta Castriconi, Cristina Bottino, Silvia Scaglione,
The success of immunotherapeutic approaches strictly depends on the immune cells interaction with cancer cells. While conventional in vitro cell cultures under-represent the complexity and dynamic crosstalk of the tumor microenvironment, animal models do not allow deciphering the anti-tumor activity of the human immune system. Therefore, the development of reliable and predictive preclinical models has become crucial for the screening of immune-therapeutic approaches. We here present an organ-on- ...
Tópico(s): Cancer Cells and Metastasis
2022 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
Alessandro Poggi, Alessandra Musso, Irene Dapino, Maria Raffaella Zocchi,
Tópico(s): Mesenchymal stem cell research
2014 - Elsevier BV | Immunology Letters
Stylianos Korasidis, Claudio Andreetti, Antonio D’Andrilli, Mohsen Ibrahim, Annamaria Ciccone, Camilla Poggi, Alessandra Siciliani, Erino Angelo Rendina,
Postoperative air leaks associated with residual pleural space is a well known complication contributing to prolong hospitalization. Many techniques have been proposed for the treatment of this complication. Between 1999 and 2009, 39 patients with air leaks associated with residual pleural space (>3 cm at chest X-ray) persisting over three days after major lung resection were enrolled in this study. All patients were treated with combined pneumoperitoneum and autologus blood patch. Pneumoperitoneum ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
2010 - Oxford University Press | Interactive Cardiovascular and Thoracic Surgery
Francesco Pelliccia, Salvatore Rosanio, Giuseppe Marazzi, Sara Poggi, Alessandra Tanzilli, Cesare Greco, Carlo Gaudio, Giuseppe Rosano,
The high risk of both stroke and major bleeding in atrial fibrillation (AF) patients with chronic kidney disease (CKD) defines an important population for whom the assessment of the balance between the risk of ischemic stroke and of bleeding is essential. The use of novel oral anticoagulants (NOACs) may be a viable option in this population due to their greater net clinical benefit than warfarin, as demonstrated by the results of the clinical phase III trials. NOACs have been found to have a greater ...
Tópico(s): Cardiac Arrhythmias and Treatments
2016 - Elsevier BV | International Journal of Cardiology
Giuseppe Marazzi, Francesco Pelliccia, Giuseppe Campolongo, Luca Cacciotti, Rosalba Massaro, Sara Poggi, Alessandra Tanzilli, Martina Di Iorio, Maurizio Volterrani, Mitja Lainščak, Giuseppe Rosano,
The ultimate goal of antihypertensive therapy is cardiovascular risk (CVR) reduction. The aim of this study was to compare the efficacy and safety of once-daily fixed combination (ODFC) versus free-drug combination (FDC) of 3antihypertensive agents and statin.The ALL-IN-ONE trial was a 12-week randomized, prospective, multicenter trial. A total of 305 hypertensive patients were randomized 1:1. The "fixed group" was given an ODFC of perindropil 10mg plus indapamide 2.5mg plus amlodipine 5 or 10mg plus ...
Tópico(s): Lipoproteins and Cardiovascular Health
2016 - Elsevier BV | International Journal of Cardiology
Cinzia Solfanelli, Alessandra Poggi, Elena Loreti, Amedeo Alpi, Pierdomenico Perata,
Abstract Sugars act as signaling molecules, whose signal transduction pathways may lead to the activation or inactivation of gene expression. Whole-genome transcript profiling reveals that the flavonoid and anthocyanin biosynthetic pathways are strongly up-regulated following sucrose (Suc) treatment. Besides mRNA accumulation, Suc affects both flavonoid and anthocyanin contents. We investigated the effects of sugars (Suc, glucose, and fructose) on genes coding for flavonoid and anthocyanin biosynthetic ...
Tópico(s): Plant Molecular Biology Research
2005 - Oxford University Press | PLANT PHYSIOLOGY
Silvia Gonzali, Elena Loreti, Giacomo Novi, Alessandra Poggi, Amedeo Alpi, Pierdomenico Perata,
The use of microarrays to characterize the transcript profile of Arabidopsis under various experimental conditions is rapidly expanding. This technique provides a huge amount of expression data, requiring bioinformatics tools to allow the proposal of working hypotheses. The aim of this study was to test the usefulness of this approach to examine the anaerobic response of Arabidopsis by evaluating the reliability of microarray data sets and by interrogation of microarray databases for the expression ...
Tópico(s): Plant responses to water stress
2005 - Oxford University Press | Annals of Botany
Elena Loreti, Alessandra Poggi, Giacomo Novi, Amedeo Alpi, Pierdomenico Perata,
Exogenous sucrose (Suc) greatly enhances anoxia tolerance of Arabidopsis (Arabidopsis thaliana) seedlings. We used the Affymetrix ATH1 GeneChip containing more than 22,500 probe sets to explore the anaerobic transcriptome of Arabidopsis seedlings kept under anoxia for 6 h in presence or absence of exogenous Suc. Functional clustering was performed using the MapMan software. Besides the expected induction of genes encoding enzymes involved in Suc metabolism and alcoholic fermentation, a large number ...
Tópico(s): Plant Molecular Biology Research
2005 - Oxford University Press | PLANT PHYSIOLOGY
Silvia Gonzali, Giacomo Novi, Elena Loreti, Fabio Paolicchi, Alessandra Poggi, Amedeo Alpi, Pierdomenico Perata,
Summary Sugars acting as signalling molecules regulate many developmental processes in plants, including lateral and adventitious root production. Turanose, a non‐metabolizable sucrose analogue, profoundly affects the growth pattern of Arabidopsis seedlings. Turanose‐treated seedlings are characterized by a very short primary root and a short hypocotyl showing the production of adventitious roots. A turanose‐insensitive ( tin ) mutant was identified and characterized. Because of a T‐DNA insertion and ...
Tópico(s): Plant tissue culture and regeneration
2005 - Wiley | The Plant Journal
Carolina Carillo, Ylenia Pecoraro, Marco Anile, Camilla Poggi, Alessandra Oliva, Davide Amore, Pietro Bruschini, Giuseppe Naldi, Sara Mantovani, Federico Francioni, Francesco Pugliese, Tiziano De Giacomo, Federico Venuta, Daniele Diso,
Lung transplantation (LT) is a viable option for a select group of patients with end-stage lung disease. However, infections are a major complication after LT, accounting for significant morbidity and mortality. Several germs may be responsible; multidrug-resistant Gram-negative (MDR-GN) bacteria are emerging. Colistin is widely used in the treatment of these infections and is administered by inhalation and/or parenterally. At our institution, in patients with tracheostomy, colistin is administered ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Elsevier BV | Transplantation Proceedings
Maria Teresa Maggiorella, Nunzia Sanarico, Gaetano Brindicci, Laura Monno, Carmen Rita Santoro, Nicola Coppola, Nunzia Cuomo, Annalisa Azzurri, Francesco Cesario, Filippo Luciani, Issa El‐Hamad, Gabriella d’Ettorre, Ombretta Turriziani, Laura Mazzuti, Alessandra Poggi, Francesca Vichi, Elisa Mariabelli, Lorenzo Surace, G Berardelli, Orietta Picconi, Alessandra Cenci, Leonardo Sernicola, Claudia Rovetto, Domenico Fulgenzi, Roberto Belli, Emanuela Salvi, Patrizia Di Zeo, Alessândra Borsetti, Barbara Ridolfi, Ruggero Losappio, Fabio Zoboli, Ivan Schietroma, Eleonora Cella, Silvia Angeletti, Massimo Ciccozzi, Stefania D’Amato, Barbara Ensoli, Stefano Buttò, Gioacchino Angarano, Sergio Babudieri, Giuseppe Corano Scheri, Miriam Lichtner, Salvatore Martini, Annamaria Mazzella, Nicola Romano, Alfredo Pansera, Emanuele Pontali, Adriana Raddi, Giulio Starnini, Serena Dell’Isola,
Abstract The proportion of new diagnoses of HIV infection in immigrants residing in Italy raised from 11% in 1992 to 29.7% in 2018. To investigate the HIV clades circulating in this community a retrospective study was performed in 557 HIV-infected immigrants living in 12 Italian cities. Immigrants originated from East-Europe and Central-Asia (11.7%), North Africa and Middle East (7.3%), South and South-East Asia (7.2%), Latin America and the Caribbean (14.4%), and sub-Saharan Africa (59.4%). More than ...
Tópico(s): HIV/AIDS Research and Interventions
2020 - Nature Portfolio | Scientific Reports
Alessandro Poggi, Silvia Boero, Alessandra Musso, Maria Raffaella Zocchi,
We have analyzed the effects of fluvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase involved in mevalonate synthesis, on human NK cell-mediated anti-tumor cytolysis. Fluvastatin inhibited the activation of the small guanosin triphosphate binding protein (GTP) RhoA and the consequent actin redistribution induced by ligation of LFA1 involved in NK-tumor target cell adhesion. Also, fluvastatin reduced ganglioside M1 rafts formation triggered through the engagement ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2013 - Public Library of Science | PLoS ONE
Alessandro Poggi, Silvia Catellani, Alessandra Musso, Maria Raffaella Zocchi,
T lymphocytes bearing the gammadelta T cell receptor are known to play an important role in the first-line defense against viral, bacterial and fungal pathogens. Two main subsets of gammadelta T cells are known, showing distinct functional behaviour: Vdelta2 T lymphocytes, circulating in the peripheral blood, are involved in the response to mycobacterial infections and certain viruses, including coxsakie virus B3 and herpes simplex virus type 2. Vdelta1 T cells are resident in the mucosal-associated ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2009 - Bentham Science Publishers | Current Medicinal Chemistry
Cristina Lecchi, Carlotta Catozzi, Valentina Zamarian, Gaia Poggi, Giorgia Borriello, Alessandra Martucciello, Domenico Vecchio, Esterina De Carlo, Giorgio Galiero, Fabrizio Ceciliani,
Brucellosis is an infectious disease caused by bacteria from the Brucella genus that can be transmitted to humans through contact with infected animals or contaminated animal products. Brucellosis also causes financial losses in animal production. Ruminants are highly susceptible to brucellosis, and the causative agent water buffaloes (Bubalus bubalis) is Brucella abortus. Circulating microRNAs (miRNAs) are cropping up as promising biomarkers for several infectious diseases. The goals of this study ...
Tópico(s): Circular RNAs in diseases
2019 - Nature Portfolio | Scientific Reports
Claudia Corti, Geraldina Poggi, Maura Massimino, Alessandra Bardoni, Renato Borgatti, Cosimo Urgesi,
Representations of own and others' body play a crucial role in social interaction. While extensive knowledge has been gathered on the neuropsychological deficits affecting body representation in adult brain lesion patients, little is known on how acquired damage to a developing brain may affect this process. We tested it on pediatric brain tumor survivors, comparing the abilities of 30 children and adolescents (aged 8–16 years) surviving from a supratentorial tumor (STT) or an infratentorial tumor ( ...
Tópico(s): Child and Animal Learning Development
2018 - Elsevier BV | Neuropsychologia
Luca Filippi, Marco Pezzati, Chiara Poggi, Stefano Marco Paolo Rossi, Alessandra Cecchi, Rita Santoro,
To compare the endocrine effects of dopamine and dobutamine in hypotensive very low birthweight (VLBW) infants.Non-blinded randomised prospective trial.Level III neonatal intensive care unit.35 hypotensive VLBW infants who did not respond to volume loading, assigned to receive dopamine or dobutamine.Haemodynamic variables and serum levels of thyroid stimulating hormone (TSH), total thyroxine (T(4)), prolactin (PRL) and growth hormone were assessed during the first 72 h of treatment and the first 72 ...
Tópico(s): Infant Development and Preterm Care
2007 - BMJ | Archives of Disease in Childhood Fetal & Neonatal
Claudia Corti, Cosimo Urgesi, Geraldina Poggi, Sandra Strazzer, Renato Borgatti, Alessandra Bardoni,
Abstract Cognitive rehabilitation may compensate for cognitive deficits of children with acquired brain injury (ABI), capitalizing on the use-dependent plasticity of a developing brain. Remote computerized cognitive training (CCT) may be delivered to patients in ecological settings, ensuring rehabilitation continuity. This work evaluated cognitive and psychological adjustment outcomes of an 8-week multi-domain, home-based CCT (Lumosity Cognitive Training) in a sample of patients with ABI aged 11–16 ...
Tópico(s): Educational and Psychological Assessments
2020 - Nature Portfolio | Scientific Reports
Viola Oldrati, Claudia Corti, Geraldina Poggi, Renato Borgatti, Cosimo Urgesi, Alessandra Bardoni,
Tópico(s): Cognitive Abilities and Testing
2020 - Springer Science+Business Media | Neuropsychology Review
Claudia Corti, Viola Oldrati, Maria Chiara Oprandi, Elisabetta Ferrari, Geraldina Poggi, Renato Borgatti, Cosimo Urgesi, Alessandra Bardoni,
Introduction . Multidisciplinary rehabilitation interventions are considered to be a need for children with acquired brain injury (ABI), in order to remediate the important sequelae and promote adjustment. Technology-based treatments represent a promising field inside the rehabilitation area, as they allow delivering interventions in ecological settings and creating amusing exercises that may favor engagement. In this work, we present an overview of remote technology-based training programs (TP) addressing ...
Tópico(s): Autism Spectrum Disorder Research
2019 - Hindawi Publishing Corporation | Behavioural Neurology
Daniela Fenoglio, Alessandro Poggi, Silvia Catellani, Florinda Battaglia, Alessandra Ferrera, Maurizio Setti, Giuseppe Murdaca, Maria Raffaella Zocchi,
Abstract In early HIV-1 infection, Vδ1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1–infected patients ex vivo–isolated Vδ1 T cells display cytoplasmic interferon-γ (IFN-γ). Interestingly, these cells coexpress cytoplasmic interleukin-17 (IL-17), and bear the CD27 surface marker of the memory T-cell subset. Vδ1 T cells, isolated from either patients ...
Tópico(s): Whipple's Disease and Interleukins
2009 - Elsevier BV | Blood
Laura Arru, Sara Rognoni, Alessandra Poggi, Elena Loreti,
Tópico(s): Plant Reproductive Biology
2008 - Springer Science+Business Media | Plant Growth Regulation
Maria Raffaella Zocchi, Caterina Camodeca, Elisa Nuti, Armando Rossello, Roberta Venè, Francesca Tosetti, Irene Dapino, Delfina Costa, Alessandra Musso, Alessandro Poggi,
Hodgkin lymphoma (HL) resistant to conventional therapies is increasing, making of interest the search for new schemes of treatment. Members of the "A Disintegrin And Metalloproteases" (ADAMs) family, mainly ADAM10 or ADAM17, have been proposed as therapeutic targets in solid tumors and some ADAMs inhibitors have been shown to exert antitumor effects. We have previously described an overexpression of ADAM10 in HL, together with increased release of NKG2D ligands (NKG2D-L) and reduced activation of effector ...
Tópico(s): Synthesis and Biological Evaluation
2015 - Landes Bioscience | OncoImmunology
Maria Raffaella Zocchi, Silvia Catellani, Paolo Canevali, Sara Tavella, Anna Garuti, Barbara Villaggio, Annalisa Zunino, Marco Gobbi, Giulio Fraternali Orcioni, Annalisa Kunkl, Jean-Louis Ravetti, Silvia Boero, Alessandra Musso, Alessandro Poggi,
Abstract Herein we describe that in classic Hodgkin lymphomas (cHL, n = 25) the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell membrane. These enzymes were detected both in LN mesenchymal stromal cells (MSCs) and in Reed-Sternberg (RS) cells; in addition, MIC-A and ULBP3 were present in culture supernatants of LN MSCs or RS cells. ...
Tópico(s): CAR-T cell therapy research
2011 - Elsevier BV | Blood
Massimo Ghio, Paola Contini, Simone Negrini, Silvia Boero, Alessandra Musso, Alessandro Poggi,
Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clones secreted TGF-beta1 upon the interaction of sHLA-I with CD8 molecule. sHLA-Cw4 or sHLA-Cw3 alleles engaging inhibitory isoforms of KIR, namely KIR2DL1 or KIR2DL2, strongly downregulated ...
Tópico(s): CAR-T cell therapy research
2009 - Wiley | European Journal of Immunology
Luca Filippi, Marco Pezzati, Alessandra Cecchi, Chiara Poggi,
Objective: To describe the possibility that dopamine infusion can prevent early diagnosis of congenital hypothyroidism. Design: Case report. Setting: Medical neonatal intensive care unit of a tertiary academic medical center. Patients: We report four preterm newborns affected by transient primary congenital hypothyroidism who showed low serum thyroxine and normal thyroid-stimulating hormone concentrations on primary screening performed during treatment with dopamine. Interventions: Thyroid reevaluation ...
Tópico(s): Neonatal Respiratory Health Research
2006 - Lippincott Williams & Wilkins | Pediatric Critical Care Medicine
Paola Contini, Maria Raffaella Zocchi, Ivana Pierri, Alessandra Albarello, Alessandro Poggi,
Tópico(s): Cell death mechanisms and regulation
2006 - Springer Nature | Leukemia
Claudia Corti, Cosimo Urgesi, Maura Massimino, Lorenza Gandola, Alessandra Bardoni, Geraldina Poggi,
Tópico(s): Memory and Neural Mechanisms
2019 - Springer Science+Business Media | Child s Nervous System
Lorenza Pugni, Beatrice Letizia Crippa, Francesco Raimondi, Giovanni Vento, Giovanna Mangili, Alessandra Coscia, Giacomo Artieri, Andrea Ronchi, Maria Luisa Ventura, Paola Lago, Carlo Pietrasanta, Riccardo Crimi, Giuseppina Bonfante, Serafina Perrone, Alessandra Boncompagni, Agostina Solinas, Massimo Agosti, Chiara Poggi, Alessandra Falcone, Claudia Pagliotta, Daniela Gianotti, Genny Gottardi, Giulia Paviotti, A Allodi, G Maffei, Alice Proto, Antonella Travierso, Serena Salomè, Simonetta Costa, Stefania Ferrari, Chiara Peila, Mariateresa Sinelli, F. Fanelli, Lucia Giordano, Martina Saruggia, Letizia Capasso, Elena Spada, Camilla Gizzi, Luigi Orfeo, Fabio Mosca,
To describe how SARS-CoV-2 infection at the time of delivery affected maternal and neonatal outcomes across four major waves of the COVID-19 pandemic in Italy.
Tópico(s): Global Maternal and Child Health
2023 - Elsevier BV | International Journal of Infectious Diseases
Alessandro Poggi, Alessandra Musso, Silvia Boero, Paolo Canevali, Maria Raffaella Zocchi,
It has been extensively shown that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase can effectively be used in the treatment of hypercholesterolemia. Indeed, coronary morbidity and mortality related to atherosclerotic plaque dependent cardiovascular diseases have been greatly reduced by their employment. Recently, it has been shown that statins can affect cell growth and survival of solid tumours and leukaemic cells. Indeed, it has been proposed their employment in ...
Tópico(s): Colorectal Cancer Treatments and Studies
2010 - Bentham Science Publishers | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Alessandro Poggi, Claudia Prevosto, Marta Zancolli, Paolo Canevali, Alessandra Musso, Maria Raffaella Zocchi,
Abstract : It is thought that human natural killer (NK) lymphocytes should not damage self‐tissues due to the inhibiting signal initiated by the engagement of one or another inhibitory receptor superfamily (IRS) members with self‐human histocompatibility antigen (HLA)‐I. During viral infection, the low expression of self‐HLA‐I on infected‐cells leads to a reduction of the inhibiting signal and thus NK cells kill self‐cells (missing self‐hypothesis). Here, we have analyzed human NK cell interaction with ...
Tópico(s): Reproductive System and Pregnancy
2007 - Wiley | Annals of the New York Academy of Sciences