Alessandro Porrello, Silvia Soddu, Joseph P. Zbilut, Marco Crescenzi, Alessandro Giuliani,
Abstract p53 is mutated in roughly 50% of all human tumors, predominantly in the DNA‐binding domain codons. Structural, biochemical, and functional studies have reported that the different p53 mutants possess a broad range of behaviors that include the elimination of the tumor‐suppression function of wild‐type protein, the acquisition of dominant‐negative function over the wild‐type form, and the establishment of gain‐of‐function activities. The contribution of each of these types of mutations to ...
Tópico(s): RNA Research and Splicing
2004 - Wiley | Proteins Structure Function and Bioinformatics
Lucia Torracca, Elisabetta Lapenna, Michele De Bonis, Samer Kassem, Giovanni La Canna, Giuseppe Crescenzi, Alessandro Castiglioni, Antonio Grimaldi, Ottavio Alfieri,
Objective To report our experience with minimally invasive mitral valve repair. Methods From 1999 to 2003, 104 patients underwent mitral valve repair through a right anterolateral minithoracotomy. Most of them were in New York Heart Association functional class I–II, had normal ejection fraction and were in sinus rhythm. Eighty-five patients suffered from severe mitral regurgitation due to degenerative disease (n = 82) or healed endocarditis (n = 3) and 19 patients had severe mitral stenosis. Sixty-two ...
Tópico(s): Aortic Disease and Treatment Approaches
2006 - Lippincott Williams & Wilkins | Journal of Cardiovascular Medicine
Alberto Zangrillo, Stefano Turi, Giuseppe Crescenzi, Alessandro Oriani, Francesco Distaso, Fabrizio Monaco, Elena Bignami, Giovanni Landoni,
beta-Blockers were associated with a reduction of mortality and morbidity in noncardiac surgery until recently when the POISE trial showed that beta-blockers could be harmful in the perioperative period because of hypotension and bradycardia. Esmolol is an ultra-short-acting beta-blocker mostly used in emergency and high-risk patients. The authors performed a meta-analysis to evaluate the clinical effects of esmolol in cardiac surgery.Meta-analysis.Hospitals.A total of 778 patients from 20 randomized ...
Tópico(s): Anesthesia and Sedative Agents
2009 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Pierluigi Crescenzi, Alessandro Panconesi,
We introduce a formal framework for studying approximation properties of NP optimization (NPO) problems. The classes of approximable problems we consider are those appearing in the literature, namely the class of approximable problems within a constant ε (APX), and the class of problems having a polynomial time approximation scheme (PTAS). We define natural approximation preserving reductions and obtain completeness results in NPO, APX, and PTAS. A complete problem in a class cannot have stronger approximation ...
Tópico(s): Advanced Graph Theory Research
1991 - Elsevier BV | Information and Computation
Paolo Gorello, Roberta La Starza, Emanuela Varasano, Sabina Chiaretti, L Elia, V. Pierini, Gianluca Barba, Lucia Brandimarte, Barbara Crescenzi, Alessandro Vitale, Monica Messina, Sara Grammatico, Marco Mancini, Caterina Matteucci, Antonella Bardi, Anna Guarini, Maria Paola Martelli, R. Foà, Cristina Mecucci,
Molecular lesions in T-cell acute lymphoblastic leukemias affect regulators of cell cycle, proliferation, differentiation, survival and apoptosis in multi-step pathogenic pathways. Full genetic characterization is needed to identify events concurring in the development of these leukemias.We designed a combined interphase fluorescence in situ hybridization strategy to study 25 oncogenes/tumor suppressor genes in T-cell acute lymphoblastic leukemias and applied it in 23 adult patients for whom immunophenotyping, ...
Tópico(s): Acute Myeloid Leukemia Research
2010 - Ferrata Storti Foundation | Haematologica
Marco d’Ischia, Orlando Crescenzi, Alessandro Pezzella, Marianna Arzillo, Lucia Panzella, Alessandra Napolitano, Vincenzo Barone,
Abstract Elucidation of the relationships between structural features and UV–visible absorption properties of 5,6‐dihydroxyindole oligomers is an essential step towards an understanding of the unique optical properties of eumelanins. Herein, we report the first combined experimental and density functional theory (DFT) investigation of the 5,6‐dihydroxyindole oligomers so far isolated. 2,2′‐Biindolyl 2 and the 2,4′‐biindolyl 3 absorb at longer wavelengths relative to 2,7′‐biindolyl 4 and their spectra ...
Tópico(s): Phytochemicals and Antioxidant Activities
2007 - Wiley | Photochemistry and Photobiology
Alessandra Napolitano, Orlando Crescenzi, Alessandro Pezzella, Giuseppe Prota,
At physiological pH values, oxidation of the neurotransmitter dopamine (DA) by the peroxidase/H2O2 system leads to, besides dopaminochrome and 5,6-dihydroxyindole resulting from oxidative cyclization of dopaminequinone (DQ), significant amounts of the neurotoxin 6-hydroxydopamine (6-OHDA) in the oxidized quinonoid form (topaminequinone, TQ). Formation of TQ was shown to depend critically on the presence of hydrogen peroxide in the reaction medium and was not observed when DA oxidation was carried out ...
Tópico(s): Antioxidant Activity and Oxidative Stress
1995 - American Chemical Society | Journal of Medicinal Chemistry
Marco Crescenzi, Alessandro Giuliani,
By using principal components analysis (PCA) we demonstrate here that the information relevant to tumor line classification linked to the activity of 1375 genes expressed in 60 tumor cell lines can be reproduced by only five independent components. These components can be interpreted as cell motility and migration, cellular trafficking and endo/exocytosis, and epithelial character. PCA, at odds with cluster analysis methods routinely used in microarray analysis, allows for the participation of individual ...
Tópico(s): Bioinformatics and Genomic Networks
2001 - Wiley | FEBS Letters
Cinzia Crescenzi, Alessandro Zorzi, Teresina Vessella, Annamaria Martino, Germana Panattoni, Alberto Cipriani, Manuel De Lazzari, Martina Perazzolo Marra, Armando Fusco, Luigi Sciarra, Fabio Sperandii, Emanuele Guerra, Eliana Tranchita, C Fossati, Fabio Pigozzi, Patrizio Sarto, Leonardo Calò, Domenico Corrado,
Background In athletes with ventricular arrhythmias (VA) and otherwise unremarkable clinical findings, cardiac magnetic resonance (CMR) may reveal concealed pathological substrates. The aim of this multicenter study was to evaluate which VA characteristics predicted CMR abnormalities. Methods and Results We enrolled 251 consecutive competitive athletes (74% males, median age 25 [17-39] years) who underwent CMR for evaluation of VA. We included athletes with >100 premature ventricular beats/24 h or ≥1 ...
Tópico(s): Cardiac Arrhythmias and Treatments
2020 - Wiley | Journal of the American Heart Association
Pierluigi Crescenzi, Alessandro Panconesi,
We introduce a formal framework for studying approximation properties of NP optimization (NPO) problems. The classes we consider are those appearing in the literature, namely the class of approximable problems within a constant ε (APX), the class of problems having a Polynomial-time Approximation Scheme (PAS) and the class of problems having a Fully Polynomial-time Approximation Scheme (FPAS). We define natural approximation preserving reductions and obtain completeness results for these classes. A ...
Tópico(s): Optimization and Search Problems
1989 - Springer Science+Business Media | Lecture notes in computer science
Magda Gioia, Giovanni Francesco Fasciglione, Diego Sbardella, Francesca Sciandra, Marialuisa Casella, Serena Camerini, Marco Crescenzi, Alessandro Gori, Umberto Tarantino, Paola Cozza, Andrea Brancaccio, Massimo Coletta, Manuela Bozzi,
Dystroglycan (DG) is a membrane receptor, belonging to the dystrophin-glycoprotein complex (DGC) and formed by two subunits, α-dystroglycan (α-DG) and β-dystroglycan (β -DG). The C-terminal domain of α-DG and the N-terminal extracellular domain of β -DG are connected, providing a link between the extracellular matrix and the cytosol. Under pathological conditions, such as cancer and muscular dystrophies, DG may be the target of metalloproteinases MMP-2 and MMP-9, contributing to disease progression. Previously, ...
Tópico(s): Peptidase Inhibition and Analysis
2018 - Public Library of Science | PLoS ONE
Michele Danilo Pierri, Giuseppe Crescenzi, Carlo Zingaro, Alessandro D’Alfonso, Filippo Capestro, Vitangelo Scocco, Marina Brugia, Lucia Torracca,
Tópico(s): Cardiac and Coronary Surgery Techniques
2016 - Springer Science+Business Media | General Thoracic and Cardiovascular Surgery
Pietro Bagolan, Germana Casaccia, F Crescenzi, A. Nahom, Alessandro Trucchi, Claudio Giorlandino,
There is considerable debate regarding the optimal management of congenital diaphragmatic hernia (CDH) in high-risk infants (those cases presenting with respiratory distress within 2 hours of birth or those diagnosed prenatally). The aim of this study was to analyze patient outcomes using a new treatment protocol for CDH in a tertiary care non-extracorporeal membrane oxygenation (ECMO) neonatal unit.The records of 78 consecutive neonates with CDH presenting to Bambino Gesù Children's Hospital from ...
Tópico(s): Congenital Anomalies and Fetal Surgery
2004 - Elsevier BV | Journal of Pediatric Surgery
Vincenzo Barone, Ivo Cacelli, Orlando Crescenzi, Marco d’Ischia, Alessandro Ferretti, Giacomo Prampolini, Giovanni Villani,
Aim of this paper is to present a computational revisitation of the main structural and spectroscopic features of quinhydrone, a prototype of complexes built on noncovalent interactions, with a view to proposing an accurate yet computationally convenient approach to the characterization of such kind of complexes. Several methods are compared in terms of energy profiles along selected coordinates, which involve the relative distance and/or orientation of the two aromatic rings. MP2 and DFT calculations ...
Tópico(s): Molecular spectroscopy and chirality
2013 - Royal Society of Chemistry | RSC Advances
Luigia Capelli, Orlando Crescenzi, Paola Manini, Alessandro Pezzella, Vincenzo Barone, Marco d’Ischia,
5,6-Dihydroxyindole-based systems engender increasing interest for the design and implementation of new functional aromatic scaffolds and eumelanin-like materials with tailored absorption and electronic properties. However, studies aimed at elucidating the influence of external π-conjugating groups on the redox properties and acid-induced reactivity of these highly oxidizable indolic platforms are lacking. We report herein the synthesis (as acetyl derivatives) and chemical/quantum chemical characterization ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2011 - American Chemical Society | The Journal of Organic Chemistry
Massimo Breccia, Elisabetta Abruzzese, Vincenzo Accurso, Immacolata Attolico, Sara Barulli, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Massimiliano Bonifacio, Giovanni Caocci, Isabella Capodanno, Fausto Castagnetti, Francesco Cavazzini, Elena Crisà, Monica Crugnola, Maria Stella De Candia, Chiara Elena, Carmen Fava, Sara Galimberti, Antonella Gozzini, Gabriele Gugliotta, Tamara Intermesoli, Alessandra Iurlo, Gaetano La Barba, Roberto Latagliata, Sabrina Leonetti Crescenzi, Luciano Levato, Giuseppina Loglisci, Alessandro Lucchesi, Luigiana Luciano, Francesca Lunghi, Debora Luzi, Malato Alessandra, Maria Cristina Miggiano, Pizzuti Michele, Patrizia Pregno, Davide Rapezzi, Giovanna Rege‐Cambrin, Gianantonio Rosti, Sabina Russo, Rosaria Sancetta, Anna Rita Scortechini, Federica Sorà, Paolo Sportoletti, Fabio Stagno, Agostino Tafuri, Mario Tiribelli, Robin Foà, Giuseppe Saglio,
Summary Limited information is available on the impact of the COVID‐19 pandemic on the management of chronic myeloid leukaemia (CML). The Campus CML network collected retrospective information on 8 665 CML patients followed at 46 centres throughout Italy during the pandemic between February 2020 and January 2021. Within this cohort, we recorded 217 SARS‐CoV‐2‐positive patients (2·5%). Most patients (57%) were diagnosed as having SARS‐CoV‐2 infection during the second peak of the pandemic (September ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Wiley | British Journal of Haematology
Antonio Pelliccia, Mario Tatangelo, Cristian Borrazzo, Domenico Zampaglione, Federica Mango, Elisa Fedele, Chiara Lanzillo, Annamaria Martino, Cinzia Crescenzi, Viviana Maestrini, Alessandro Zorzi, Domenico Corrado, Leonardo Calò,
Low QRS voltages (LQRSV) are an unexpected finding in left ventricular hypertrophy, i.e. hypertrophic cardiomyopathy (HCM) or athlete's heart.Prevalence and clinical correlates of LQRSV were investigated in 197 consecutive HCM patients, aged 58 ± 13 years and comparatively in 771 Olympic athletes, aged 23 ± 4. Clinical characterization included family/personal history, symptoms, New York Heart Association (NYHA) functional class, electrocardiographic pattern, ventricular arrhythmias, and cardiac magnetic ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Oxford University Press | European Journal of Preventive Cardiology
Martina Briani, Lucia Torracca, Giuseppe Crescenzi, Alessandro Barbone,
Abstract Background Left ventricular (LV) aneurysms complicate anterior myocardial infarctions (MIs) in 8–15% of cases. In case of associated LV dysfunction, rapidly evolving heart failure may follow, and urgent surgery becomes life-saving. Case summary Following an acute anterior MI treated by percutaneous coronary intervention, which resulted in apical hypokinesis, depressed LV function, and moderate mitral regurgitation, a 70-year-old male patient kept in contact with our cardiology department ...
Tópico(s): Cardiac Arrest and Resuscitation
2021 - Oxford University Press | European Heart Journal - Case Reports
Valentina Pierini, Valentina Bardelli, Fabio Giglio, Silvia Arniani, Caterina Matteucci, Fabrizia Pellanera, Martina Quintini, Barbara Crescenzi, Alessandro Bruno, Elena Sabattini, Emanuela Falcinelli, Loredana Ruggeri, Paola Ronchi, Maurilio Ponzoni, Fabio Ciceri, Cristina Mecucci, Roberta La Starza,
T-cell acute lymphoblastic leukemia (T-ALL) is a rare subtype of ALL generally considered to behave less favorable than B-cell ALL, in particular when it displays an immature phenotype (early T-cell precursor [ETP]-ALL). It has a heterogeneous genetic background, characterized by the nonrandom involvement of multiple genes, which concur to delineate specific leukemogenic pathways.1 However, although recurrent alterations of transcription factors are useful to assign the leukemia to distinct genetic ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2022 - Wolters Kluwer | HemaSphere
F. Crescenzi, Antonella Crisari, Edoardo D'Angel, Alessandro Nardella,
The global production of sulfur, which is currently obtained almost exclusively as an involuntary byproduct of the oil and gas industry, is exceeding the market demand so that long term storage or even definitive disposal of elemental sulfur is often needed to handle production surplus. The storage of large quantities of elemental sulfur calls for solidifying liquid sulfur in huge blocks, hundred meters wide on each side and as high as 20 meters. Sulfur, in presence of water and air, can be oxidized ...
Tópico(s): Composting and Vermicomposting Techniques
2006 - American Chemical Society | Environmental Science & Technology
Ida Casorelli, Elena Tenedini, Enrico Tagliafico, Monica Francesca Blasi, Alessandro Giuliani, Marco Crescenzi, Elvira Pelosi, Ugo Testa, C Peschle, Luca Mele, Daniela Diverio, Massimo Breccia, Francesco Lo‐Coco, Sérgio Ferrari, Margherita Bignami,
Tópico(s): Advanced biosensing and bioanalysis techniques
2006 - Springer Nature | Leukemia
Gianluca Bossi, Giuseppina Mazzaro, Alessandro Porrello, Marco Crescenzi, Silvia Soddu, Ada Sacchi,
Tópico(s): Cancer-related Molecular Pathways
2004 - Springer Nature | Oncogene
Nicoletta Testoni, Giulia Marzocchi, Simona Luatti, Marilina Amabile, Carmen Baldazzi, Monica Stacchini, Mauro Nanni, Giovanna Rege‐Cambrin, Emilia Giugliano, Ursula Giussani, Elisabetta Abruzzese, Simonetta Kerim, Maria Grazia Grimoldi, Alessandro Gozzetti, Barbara Crescenzi, Carlo Carcassi, Paolo Bernasconi, Antonio Cuneo, Francesco Albano, Giuseppina Fugazza, Alfonso Zaccaria, Giovanni Martinelli, Fabrizio Pane, Gianantonio Rosti, Michele Baccarani,
Abstract In chronic myeloid leukemia, different methods are available to monitor the response to therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization (I-FISH), and real-time quantitative polymerase chain reaction (RT-Q-PCR). The GIMEMA CML WP (Gruppo Italiano Malattie Ematologiche Adulto Chronic Myeloid Leukemia Working Party) has performed a prospective study to compare CBA and I-FISH for the definition of complete cytogenetic response (CCgR). Samples (n = 664) were ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2009 - Elsevier BV | Blood
Marianna Arzillo, Alessandro Pezzella, Orlando Crescenzi, Alessandra Napolitano, Edward J. Land, Vincenzo Barone, Marco d’Ischia,
An unprecedented 5,6-dihydroxyindole macrocycle (4) featuring a rigid twisted backbone was obtained by biomimetic oxidative cross-coupling of the 2,2′-biindole 2 and triindole 3. A putative reaction intermediate, 2-quinone, was detected and characterized by pulse radiolysis and DFT calculations. Discovery of 4 indirectly supports for the first time theoretically predicted cyclic structural motifs as potential eumelanin building blocks.
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2010 - American Chemical Society | Organic Letters
Alessandro Pezzella, Orlando Crescenzi, Anna Natangelo, Lucia Panzella, Alessandra Napolitano, Suppiah Navaratnam, Ruth Edge, Edward J. Land, Vincenzo Barone, Marco d’Ischia,
The chemical and spectroscopic characterization of 5,6-indolequinones and their semiquinones, key transient intermediates in the oxidative conversion of 5,6-dihydroxyindoles to eumelanin biopolymers, is a most challenging task. In the present paper, we report the characterization of a novel, relatively long-lived 5,6-indolequinone along with its semiquinone using an integrated chemical, pulse radiolytic, and computational approach. The quinone was obtained by oxidation of 5,6-dihydroxy-3-iodoindole ( ...
Tópico(s): Phytochemicals and Antioxidant Activities
2007 - American Chemical Society | The Journal of Organic Chemistry
Alessandro Pezzella, Orlando Crescenzi, Lucia Panzella, Alessandra Napolitano, Edward J. Land, Vincenzo Barone, Marco d’Ischia,
As a rule, o-semiquinones decay through disproportionation leading to equimolar amounts of catechol and o-quinone products. However, the o-semiquinone 1S generated by pulse radiolysis oxidation of the eumelanin precursor 5,6-dihydroxyindole (1) decays with second-order kinetics to generate broad visible chromophores that are incompatible with the predicted absorption of 5,6-indolequinone (1Q). Using an integrated chemical, pulse radiolytic and computational approach as well as deuterium labeling, ...
Tópico(s): Radical Photochemical Reactions
2013 - American Chemical Society | Journal of the American Chemical Society
Raffaella Micillo, Lucia Panzella, Mariagrazia Iacomino, Giacomo Prampolini, Ivo Cacelli, Alessandro Ferretti, Orlando Crescenzi, K Koike, Alessandra Napolitano, Marco d’Ischia,
Eumelanins, the chief photoprotective pigments in man and mammals, owe their black color to an unusual broadband absorption spectrum whose origin is still a conundrum. Excitonic effects from the interplay of geometric order and disorder in 5,6-dihydroxyindole (DHI)-based oligomeric/polymeric structures play a central role, however the contributions of structural (scaffold-controlled) and redox (π-electron-controlled) disorder have remained uncharted. Herein, we report an integrated experimental-theoretical ...
Tópico(s): Olfactory and Sensory Function Studies
2017 - Nature Portfolio | Scientific Reports
Andrea Clementi, Pierluigi Crescenzi, Carola Doerr, Pierre Fraigniaud, Marco Isopi, Alessandro Panconesi, Francesco Pasquale, Riccardo Silvestri,
In this paper, we aim at analyzing the classical information spreading push protocol in dynamic networks. We consider the edge-Markovian evolving graph model which captures natural temporal dependencies between the structure of the network at time t, and the one at time t + 1. Precisely, a non-edge appears with probability p, while an existing edge dies with probability q. In order to fit with real-world traces, we mostly concentrate our study on the case where $p=\Omega(\frac{1}{n})$ and q is constant. ...
Tópico(s): Cellular Automata and Applications
2013 - Springer Science+Business Media | Lecture notes in computer science
Alessandro Cuomo, Bruno Beccarini Crescenzi, Arianna Goracci, Simone Bolognesi, N. Giordano, Rodolfo Rossi, Edvige Facchi, Stephen M Neal, Andrea Fagiolini,
Introduction: Safety and tolerability of medications are key variables to inform treatment choice for patients with bipolar disorder (BD). This review focuses on the overall tolerability and safety profile of aripiprazole when used for its bipolar disorder indications, which include acute treatment of manic and mixed episodes and maintenance treatment of bipolar I disorder for the oral formulation, agitation associated with bipolar mania for the injectable immediate-release formulation, and maintenance ...
Tópico(s): Electroconvulsive Therapy Studies
2019 - Taylor & Francis | Expert Opinion on Drug Safety
Alessandro Cuomo, Bruno Beccarini Crescenzi, Simone Bolognesi, Arianna Goracci, Despoina Koukouna, Rodolfo Rossi, Andrea Fagiolini,
Abstract Background Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact. S -Adenosylmethionine (SAMe), a molecule that is formed naturally in the human body, has shown antidepressant effects and may expand the available options for treating MDD. This systematic review examines the evidence concerning the efficacy of SAMe as monotherapy or in combination with antidepressants. Methods A systematic search in Medline, ...
Tópico(s): Alcoholism and Thiamine Deficiency
2020 - BioMed Central | Annals of General Psychiatry