Charles Owen, John Huxley, Leslie Watkins, Rosemary Righter, Stephen Dodgson, Tom Phillips, Keith Hindley, Jon Swain, Alan Gibson, Athole Still, John Vincent, Norman Leorecht, Chris Tighe, Peter Calvocoressi, Graham Rose, Arnold Goodman, John Whale, Frederic Raphael, Cal McCrystal, Mark Hosenball, Jancis Robinson, Robert Hill Area Officer, Richard Jenkyns, Henry Brandon, John Coates, Richard Milner, Jim Pegg, Keith Botsford, Robin Wright, David Dougill, John Mortimer, Jim Railton, Veronica Horwell, Cliff Temple, Derek Jewell, Clive Graham-Ranger, Nicholas Shrimpton, D. J. Livock, David Cairns, John Curzon, Norman Harris, Adrianne Blue, David Blundy, Chris Coldrey, Geoffrey Cannon, Brian Wilson, George Perry, Robin Marlar, Nick Anning, Phil Finnegan, John Sheppard, Danah Zohar, Nicholas Anderson, Patrick Forman, Ann Boyd, Peter Shearlock, Bob Mellish, Sue Samuels, Richard Brooks, David Hughes, Muriel Bowen Local Government Correspondent, Richard Girling, Nick Gilbert, Richard Brown, John Hopkins, Eric Marsden, Jonathan Raban, Bryan Silcock, Simon Freeman, Stephen Pile, Eric Jacobs, Malcolm Winton, Murray Williams, Elaine Potter, Simon Frith, Angela Wilkes, David May, Tony Levene, Desmond Shawe-Taylor, Joseph Wright, Betka Zamoyska, Russell Davies, Felix Apprahaman, H. Orr-Ewing Chairman, Ronald Butt, Dilys Powell, R Marriott, Clive Limpkin, Bill Cater, Richard Brooks Technology Correspondent, Deyan Sudjic, Oliver Gillie, Sir Brian Young, Kim Fletcher, Barrie Penrose, Dudley Doust, Felix Aprahamian, Barbara Gilgallon, Peter Chippindale, J W Lambert, Peter Clarke, (Mrs) S. B. R. Hood, Bill Carter, Misha Donat, James Fenton, Arthur Jacobs, Michael Jones Political Correspondent, Roy Perrott, Jacquetta Hawkes, Derek Randall, S. L. Lowndes, Phillip Knightley, Susie Cornfield, Alastair Bruce, Mary Brook, Harry Coen, Kate Singleton, Philippa Collingwood Full-time mother, Joan Smith, Isabel Hilton, Boris Schapiro,
... in disorder Dramatic risks on TV Gatão Vinho Verde A 'dark age' for the Jews Lay off ... the peg Music for summer nights Early Music Alessandro Stradella: San Glovanni Battista/soloists/chorus/Capella Clementina/ ...
1982 - Gale Group | Sunday Times HA GDA
Cinzia Verde, Alessandro Vergara, L. Mazzarella, Guido di Prisco,
Fishes thriving in polar habitats offer many opportunities for comparative approaches to understanding protein adaptations to temperature. Notothenioidei, the dominant suborder in the Antarctic Ocean, have evolved reduction of hemoglobin concentration and multiplicity, perhaps as a consequence of temperature stability and other environmental parameters. In the icefish family, the blood pigment is absent. In contrast, similar to other acanthomorph teleosts, Arctic fish, thriving in a more complex ...
Tópico(s): Physiological and biochemical adaptations
2008 - Bentham Science Publishers | Current Protein and Peptide Science
Cinzia Verde, Alessandro Vergara, Daniela Giordano, L. Mazzarella, Guido di Prisco,
Abstract Haemoglobin carries oxygen from the environment to tissues; in vertebrates, it is contained in specialized cells, called erythrocytes. Over the last century, the study of the chemical properties of this haemoprotein has provided a wealth of information. One of its most important and ancient physiological features is the Root effect, found in many teleost fish (and some amphibians). The Root effect corresponds to an extreme pH sensitivity and can be described as an exaggerated Bohr effect: ...
Tópico(s): Erythrocyte Function and Pathophysiology
2007 - Cambridge University Press | Antarctic Science
Alessandra Astegno, Elena Maresi, Mariarita Bertoldi, Valentina La Verde, Alessandro Paiardini, Paola Dominici,
Toxoplasma gondii is a protozoan parasite of medical and veterinary relevance responsible for toxoplasmosis in humans. As an efficacious vaccine remains a challenge, chemotherapy is still the most effective way to combat the disease. In search of novel druggable targets, we performed a thorough characterization of the putative pyridoxal 5'-phosphate (PLP)-dependent enzyme ornithine aminotransferase from T. gondii ME49 (TgOAT). We overexpressed the protein in Escherichia coli and analysed its molecular ...
Tópico(s): Parasitic Infections and Diagnostics
2017 - Portland Press | Biochemical Journal
Raffaele Mazziotti, Fabio Carrara, Aurelia Viglione, Leonardo Lupori, Luca Lo Verde, Alessandro Benedetto, G. Ricci, Giulia Sagona, Giuseppe Amato, Tommaso Pizzorusso,
Abstract Pupil dynamics alterations have been found in patients affected by a variety of neuropsychiatric conditions, including autism. Studies in mouse models have used pupillometry for phenotypic assessment and as a proxy for arousal. Both in mice and humans, pupillometry is noninvasive and allows for longitudinal experiments supporting temporal specificity; however, its measure requires dedicated setups. Here, we introduce a convolutional neural network that performs online pupillometry in both ...
Tópico(s): Receptor Mechanisms and Signaling
2021 - Society for Neuroscience | eNeuro
C Cernigliaro, Mara Sansa, Giancarlo Vitrella, Alessandro Verde, Angelo Sante Bongo, Luigi Giuliani, Eugenio Novelli,
<i>Objectives:</i> To establish the efficacy of oral rapamycin at a dose of 2 mg for 1 month at reducing the 6-month restenosis rate after the implantation of bare metal stents. <i>Methods:</i> A prospective, 1:1 randomized, single-blind, placebo-controlled study was conducted in 108 consecutive patients assigned immediately after stent implantation to oral rapamycin (4 mg loading dose followed by 2 mg daily for 30 days) or a placebo. <i>Results:</i> Rapamycin was maintained ...
Tópico(s): Acute Myocardial Infarction Research
2009 - Karger Publishers | Cardiology
Raffaele Caruso, Benedetta De Chiara, Jonica Campolo, Alessandro Verde, F. Musca, Oriana Belli, Marina Parolini, Lorena Cozzi, Antonella Moreo, Maria Frigerio, Oberdan Parodi,
Neopterin, a marker of inflammation and monocyte activation, is found increased in patients with heart failure (HF). This study investigates whether neopterin levels correlate with left ventricular (LV) remodeling and brain natriuretic peptide (BNP), a marker of cardiac stress, in chronic HF (CHF) patients with different severity of disease. The relationship between neopterin and LV dimensions, NT-proBNP, and pro-inflammatory cytokines were studied in 98 CHF patients, while nineteen healthy subjects ...
Tópico(s): Metabolism and Genetic Disorders
2012 - Elsevier BV | Clinical Biochemistry
Raffaele Caruso, Luca Botta, Alessandro Verde, Filippo Milazzo, Irene Vecchi, Maria Giovanna Trivella, Luigi Martinelli, Roberto Paino, Maria Frigerio, Oberdan Parodi,
The immune response is crucial in the development of multi-organ failure (MOF) and complications in end-stage heart failure patients supported by left ventricular assist device (LVAD). However, at pre-implant, the association between inflammatory state and post-LVAD outcome is not yet clarified. Aim of the study was to assess the relationship among pre-implant levels of immune-related cytokines, postoperative inflammatory response and 3-month outcome in LVAD-patients.In 41 patients undergoing LVAD ...
Tópico(s): Heart Failure Treatment and Management
2014 - Public Library of Science | PLoS ONE
Attilio Iacovoni, Paolo Centofanti, Matteo Attisani, Alessandro Verde, Amedeo Terzi, Michele Senni, Massimo Maiani, Andrea Baronetto, Ugolino Livi, Maria Frigerio, Mauro Rinaldi,
Background Left ventricular assist device (LVAD) implantation improves survival and quality of life in patients with advanced heart failure (HF). Despite these advantages, LVADs are not free from risks. Among all adverse events (AE), pump thrombosis and bleeding, especially of the gastrointestinal (GI) tract, have been reported to occur with increasing frequency in some CF-LVADs. The INCOR LVAD system is a third-generation, continuous flow, axial pump with active magnetic levitation, avoiding the potential ...
Tópico(s): Heart Failure Treatment and Management
2015 - SAGE Publishing | The International Journal of Artificial Organs
Cristina Barsanti, Maria Giovanna Trivella, Romina D’Aurizio, Mariama El Baroudi, Mario Baumgart, Marco Groth, Raffaele Caruso, Alessandro Verde, Luca Botta, Lorena Cozzi, Letizia Pitto,
Mechanical unloading by left ventricular assist devices (LVADs) in advanced heart failure (HF), in addition to improving symptoms and end-organ perfusion, is supposed to stimulate cellular and molecular responses which can reverse maladaptive cardiac remodeling. As microRNAs (miRNAs) are key regulators in remodeling processes, a comparative miRNA profiling in transplanted hearts of HF patients with/without LVAD assistance could aid to comprehend underlying molecular mechanisms. Next generation sequencing ( ...
Tópico(s): MicroRNA in disease regulation
2015 - Hindawi Publishing Corporation | BioMed Research International
Fabrizio Oliva, Enrico Perna, Marco Marini, Daniele Nassiacos, Antonio Cirò, Gabriella Malfatto, Fabrizio Morandi, I. Caico, Gianpiero Perna, Sabina Meloni, Antonella Vincenzi, Alessandra Villani, Andrea Vecchi, Chiara Minoia, Alessandro Verde, Renata De Maria,
Ambulatory Advanced Heart Failure (AAHF) is characterized by recurrent HF hospitalizations, escalating diuretic requirements, intolerance to neurohormonal antagonists, end-organ dysfunction, short-term reduced life expectancy despite optimal medical management (OMM). The role of intermittent inotropes in AAHF is unclear. The RELEVANT-HF registry was designed to obtain insight on the effectiveness and safety of compassionate scheduled repetitive 24-hour levosimendan infusions (LEVO) in AAHF patients. ...
Tópico(s): Cardiac Arrest and Resuscitation
2018 - Elsevier BV | International Journal of Cardiology
Alessandro Verde, Maria Mangini, Stefano Managò, Chiara Tramontano, Ilaria Rea, Diana Boraschi, Paola Italiani, Anna Chiara De Luca,
Engineered gold nanoparticles (AuNPs) find application in several fields related to human activities ( i.e. , food and cosmetic industry or water purification) including medicine, where they are employed for diagnosis, drug delivery and cancer therapy. As for any material/reagent for human use, the safety of AuNPs needs accurate evaluation. AuNPs are prone to contamination by bacterial endotoxin (lipopolysaccharide, LPS), a potent elicitor of inflammatory responses in mammals. It is therefore important, ...
Tópico(s): Nanoplatforms for cancer theranostics
2021 - Frontiers Media | Frontiers in Immunology
Maria Mangini, Alessandro Verde, Diana Boraschi, Víctor Puntes, Paola Italiani, Anna Chiara De Luca,
The interaction between engineered nanoparticles and the bacterial lipopolysaccharide, or endotoxin, is an event that warrants attention. Endotoxin is one of the most potent stimulators of inflammation and immune reactions in human beings, and is a very common contaminant in research labs. In nanotoxicology and nanomedicine, the presence of endotoxin on the nanoparticle surface affects their biological properties leading to misinterpretation of results. This review discusses the importance of detecting ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Taylor & Francis | Nanotoxicology
Alessandro Maloberti, Nicola Ughi, Davide Paolo Bernasconi, Paola Rebora, Iside Cartella, E Grasso, Deborah Lenoci, Francesca Del Gaudio, Michela Algeri, Sara Scarpellini, Enrico Perna, Alessandro Verde, Caterina Santolamazza, Francesco Vicari, Maria Frigerio, Antonia Albertí, Maria Grazia Valsecchi, Claudio Rossetti, Oscar Massimiliano Epis, Cristina Giannattasio,
The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection ...
Tópico(s): Heart rate and cardiovascular health
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Benjamin J. Swartzwelter, Alessandro Verde, Laura Rehak, Mariusz P. Madej, Víctor Puntes, Anna Chiara De Luca, Diana Boraschi, Paola Italiani,
Understanding the modes of interaction between human monocytes/macrophages and engineered nanoparticles is the basis for assessing particle safety, in terms of activation of innate/inflammatory reactions, and their possible exploitation for medical applications. In vitro assessment of nanoparticle-macrophage interaction allows for examining the response of primary human cells, but the conventional 2D cultures do not reproduce the three-dimensional spacing of a tissue and the interaction of macrophages ...
Tópico(s): Immune cells in cancer
2021 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Raffaele Caruso, Alessandro Verde, Manuela Cabiati, Filippo Milazzo, Chiara Boroni, Silvia Del Ry, Marina Parolini, Claudia Vittori, Roberto Paino, Luigi Martinelli, Daniela Giannessi, Maria Frigerio, Oberdan Parodi,
Inflammatory mechanisms are associated with worse prognosis in end-stage heart failure (ESHF) patients who require left ventricular assist device (LVAD) support. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles describe patient condition at pre-implant and outcome. This study assessed the relationship among inflammation patterns and INTERMACS profiles in LVAD recipients.Thirty ESHF patients undergoing LVAD implantation as bridge to transplant were enrolled. Blood ...
Tópico(s): Aortic Disease and Treatment Approaches
2012 - Elsevier BV | The Journal of Heart and Lung Transplantation
Raffaele Caruso, Alessandro Verde, Jonica Campolo, Filippo Milazzo, Claudio Russo, Chiara Boroni, Marina Parolini, Salvatore Trunfio, Roberto Paino, Luigi Martinelli, Maria Frigerio, Oberdan Parodi,
This study investigates the impact of early left ventricular (LV)-mechanical unloading on systemic oxidative stress and inflammation in terminal heart failure patients and their impact both on multi organ failure and on intensive care unit (ICU) stay. Circulating levels of urinary 15-isoprostane-F2t (8-epi-PGF2α) and pro-inflammatory markers [plasma interleukin (IL)-6, IL-8, and urinary neopterin, a monocyte activation index] were analyzed in 20 healthy subjects, 22 stable end-stage heart failure (ESHF) ...
Tópico(s): Cardiac Ischemia and Reperfusion
2012 - Elsevier BV | Cytokine
Enrico Ammirati, Fabrizio Oliva, Tiziano Colombo, Claudio Russo, Manlio Cipriani, Andrea Garascia, Valentina Guida, Giulia Colombo, Alessandro Verde, Enrico Perna, Aldo Cannata, Roberto Paino, Luigi Martinelli, Maria Frigerio,
Tópico(s): Heart Failure Treatment and Management
2015 - Springer Science+Business Media | Heart and Vessels
Produção Nacional
Revisado por pares
Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Víctor Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi,
Innate immune memory is characterized by a modulation in the magnitude with which innate immune cells such as monocytes and macrophages respond to potential dangers, subsequent to previous exposure to the same or unrelated agents. In this study, we have examined the capacity of gold nanoparticles (AuNP), which are already in use for therapeutic and diagnostic purposes, to modulate the innate memory induced by bacterial agents. The induction of innate memory was achieved in vitro by exposing human ...
Tópico(s): COVID-19 Impact on Reproduction
2020 - Multidisciplinary Digital Publishing Institute | Cells
Davide Tosi, Alessandro Verde, Manuela Verde,
Background The fatality rate of coronavirus disease (COVID-19) in Italy is controversial and is greatly affecting discussion on the impact of containment measures that are straining the world’s social and economic fabric, such as instigating large-scale isolation and quarantine, closing borders, imposing limits on public gatherings, and implementing nationwide lockdowns. Objective The scientific community, citizens, politicians, and mass media are expressing concerns regarding data suggesting that ...
Tópico(s): COVID-19 diagnosis using AI
2020 - JMIR Publications | Journal of Medical Internet Research
Paola Caramaschi, Stefania Marocco, Maria Gobbo, Valentina La Verde, Alessandro Volpe, L M Bambara, Domenico Biasi,
We describe a case of systemic lupus erythematosus complicated by strongyloidiasis. The parasitic infection appeared with diarrhoea, weight loss and peripheral eosinophilia in association with recurrence of polyarthritis, probably due to a flare of systemic lupus erythematosus. The literature about the coexistence of systemic lupus erythematosus and strongyloidiasis has been reviewed.
Tópico(s): Eosinophilic Disorders and Syndromes
2009 - SAGE Publishing | Lupus
Tommaso Prescimone, Andrea D’Amico, Chiara Caselli, Manuela Cabiati, Federica Viglione, Raffaele Caruso, Alessandro Verde, Silvia Del Ry, Maria Giovanna Trivella, Daniela Giannessi,
Caspase (Casp)-1 has been indicated as a molecular target capable of preventing the progression of cardiovascular diseases, including heart failure (HF), due to its central role in promoting inflammation and cardiomyocyte loss. The aim of this study was to assess whether Left Ventricular Assist Device (LVAD) implantation modifies the inflammatory and apoptotic profile in the heart through the modulation of Casp-1 expression level.Cardiac tissue was collected from end-stage HF patients before LVAD implant ( ...
Tópico(s): Cardiac Ischemia and Reperfusion
2014 - Elsevier BV | Cardiovascular Pathology
C. Camerlingo, Alessandro Verde, Lorenzo Manti, Roberta Meschini, Ines Delfino, Maria Lepore,
Graphene provides a unique way of sensing the local pH level of substances on the micrometric scale, with important implications for the monitoring of cellular metabolic activities where proton excretion could occur. Accordingly, an innovative biosensing approach for the quantification of the pH value of biological fluids, to be used also with small amounts of fluids, was realized and tested. It is based on the use of micro-Raman spectroscopy to detect the modifications of the graphene doping level ...
Tópico(s): Polymer Nanocomposite Synthesis and Irradiation
2018 - Multidisciplinary Digital Publishing Institute | Sensors
Philippe-Primo Caimmi, Rita Fossaceca, Marco Lanfranchi, Marco Lanfranchi, Alessandro Verde, Alessandro Panella, Alessandro Panella, Rita Fossaceca, Marco Lanfranchi, Emmanouil Ι. Kapetanakis, Ezio Micalizzi,
Precise evaluation of the cardiac and thoracic anatomy of the patient is mandatory for planning safe minimally invasive direct coronary artery bypass (MIDCAB). Three-dimensional images obtained with a computed tomographic coronary angiography (angio-CT) scan make it possible to accurately visualize the intrathoracic surgical anatomy in order to check the feasibility of the direct exposure of the anatomical structures involved in the surgical procedure. Particular morphological parameters of coronary ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2004 - Carden Jennings Publishing Co. | The Heart Surgery Forum
Domenico Giordano, Francesca Magri, Flavia Persechino, Alejandra Lepore, Romina Verde, Alessandro Capalbo, Severino Persechino,
The proposed role of interleukin (IL)-17 in vitiligo pathogenesis, as well as the possible action of anti-IL-17A drugs on vitiligo, are not fully understood. The appearance of vitiligo as a paradoxical effect of treatment with anti-tumor necrosis factor-α drugs is an event well known in the literature, but is rarely described with anti-IL-17A drugs. In this case report, we describe a 42-year-old woman who developed new-onset vitiligo with repigmentation during successful secukinumab therapy for psoriatic ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2021 - Karger Publishers | Case Reports in Dermatology
Tommaso Prescimone, Silvia Masotti, Andrea D’Amico, Raffaele Caruso, Manuela Cabiati, Chiara Caselli, Federica Viglione, Alessandro Verde, Silvia Del Ry, Daniela Giannessi,
Cardiomyocyte apoptosis increases in heart failure (HF) and is implicated in disease progression. The apoptotic cell is not inevitably committed to death, and appropriate therapy like left ventricular assist device (LVAD) support could offer a rescue of cellular functions. Literature data regarding the modulation of the apoptotic process during LVAD support are still controversial. To assess whether LVAD implantation modifies the apoptotic profile in the heart, cardiac tissue was collected from end- ...
Tópico(s): Cardiac Structural Anomalies and Repair
2014 - Elsevier BV | Cardiovascular Pathology
Evaggelos Karvounis, Markos G. Tsipouras, Alexandros T. Tzallas, Nikolaos Katertsidis, Kostas Stefanou, Yorgos Goletsis, Maria Frigerio, Alessandro Verde, Raffaele Caruso, Bart Meyns, John Terrovitis, Maria Giovanna Trivella, Dimitrios I. Fotiadis,
Summary Background: Heart failure (HF) is affecting millions of people every year and it is characterized by impaired ventricular performance, exercise intolerance and shortened life expectancy. Despite significant advancements in drug therapy, mortality of the disease remains excessively high, as heart transplant remains the gold standard treatment for end-stage HF when no contraindications subsist. Traditionally, implanted Ventricular Assist Devices (VADs) have been employed in order to provide ...
Tópico(s): Cardiac Structural Anomalies and Repair
2014 - Thieme Medical Publishers (Germany) | Methods of Information in Medicine
Marco La Verde, Gaetano Riemma, Alessandro Tropea, Antonio Biondi, Stefano Cianci,
Abstract In the last decade, Ultra-minimally invasive surgery (UMIS) including both minilaparoscopic (MH) and percutaneous (PH) endoscopic surgery achieved widespread use around the world. Despite UMIS has been reported as safe and feasible surgical procedure, most of the available data are drawn from retrospective studies, with a limited number of cases and heterogeneous surgical procedures included in the analysis. This literature review aimed to analyze the most methodologically valid studies concerning ...
Tópico(s): Endometriosis Research and Treatment
2022 - Springer Science+Business Media | Updates in Surgery
Piero Gentile, Rosaria Cantone, Enrico Perna, Enrico Ammirati, Marisa Varrenti, Luciana D’Angelo, Alessandro Verde, Grazia Foti, Gabriella Masciocco, Andrea Garascia, Maria Frigerio, Manlio Cipriani,
The angiotensin receptor-neprilysin inhibitor (ARNI), sacubitril/valsartan, has been shown to be effective in treatment of patients with heart failure (HF), but limited data are available in patients with advanced disease. This retrospective observational study assessed the effects of ARNI treatment in patients with advanced HF.
Tópico(s): Cardiac pacing and defibrillation studies
2022 - Wiley | ESC Heart Failure
Claudia Pivonello, Giovanna Muscogiuri, Antonio Nardone, Francesco Garifalos, Donatella Paola Provvisiero, Nunzia Verde, Cristina de Angelis, Alessandro Conforti, Mariangela Piscopo, Renata S. Auriemma, Annamaria Colao, Rosario Pivonello,
Abstract Bisphenol-A (BPA) has been reported to be associated to female infertility. Indeed, BPA has been found to be more frequently detected in infertile women thus leading to hypothesize a possible effect of BPA on natural conception and spontaneous fecundity. In addition, in procedures of medically assisted reproduction BPA exposure has been found to be negatively associated with peak serum estradiol levels during gonadotropin stimulation, number of retrieved oocytes, number of normally fertilized ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2020 - BioMed Central | Reproductive Biology and Endocrinology