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Artigo Acesso aberto Revisado por pares

Xenofon Fafoutis, Alessio Di Mauro, Charalampos Orfanidis, Nicola Dragoni,

While energy consumption is widely considered the primary challenge of wireless networked devices, energy harvesting emerges as a promising way of powering the Internet of Things (IoT). In the Medium Access Control (MAC) layer of the communication stack, energy harvesting introduces spatial and temporal uncertainty in the availability of energy. In this context, this paper focuses on the design and implementation of the MAC layer of wireless embedded systems that are powered by energy harvesting; ...

Tópico(s): Wireless Networks and Protocols

2015 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Consumer Electronics

Artigo Revisado por pares

Xenofon Fafoutis, Alessio Di Mauro, Meththika Vithanage, Nicola Dragoni,

One of the fundamental building blocks of a Wireless Sensor Network (WSN) is the Medium Access Control (MAC) protocol, that part of the system governing when and how two independent neighboring nodes activate their respective transceivers to directly interact. Historically, data exchange has always been initiated by the node willing to relay data, i.e. the sender. However, the Receiver-Initiated paradigm introduced by Lin et al. in 2004 with RICER and made popular by Sun et al. in 2008 with RI-MAC, ...

Tópico(s): Energy Harvesting in Wireless Networks

2014 - Elsevier BV | Computer Networks

Artigo Acesso aberto Revisado por pares

Alessio Di Mauro, Xenofon Fafoutis, Nicola Dragoni,

Energy Harvesting Wireless Sensor Networks (EH-WSNs) represent an interesting new paradigm where individual nodes forming a network are powered by energy sources scavenged from the surrounding environment. This technique provides numerous advantages, but also new design challenges. Securing the communications under energy constraints represents one of these key challenges. The amount of energy available is theoretically infinite in the long run but highly variable over short periods of time, and ...

Tópico(s): Energy Efficient Wireless Sensor Networks

2015 - Hindawi Publishing Corporation | International Journal of Distributed Sensor Networks

Artigo Acesso aberto Revisado por pares

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Fiore, Armando Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, D Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, G Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaò, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Antonio Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Tolva, Ilenia D’Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D’Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto M. Settembrini,

Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI).Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included.One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated.Information ...

Tópico(s): Cerebrovascular and Carotid Artery Diseases

2023 - Multidisciplinary Digital Publishing Institute | Journal of Personalized Medicine

Capítulo de livro Revisado por pares

Alessio Di Mauro, Xenofon Fafoutis, Sebastian Mödersheim, Nicola Dragoni,

In receiver-initiated MAC protocols for Wireless Sensor Networks (WSNs), communication is initiated by the receiver of the data through beacons containing the receiver’s identity. In this paper, we consider the case of a network intruder that captures and replays such beacons towards legitimate nodes, pretending to have a fake identity within the network. To prevent this attack we propose RAP, a challenge-response authentication protocol that is able to detect and prevent the beacon replay attack. ...

Tópico(s): User Authentication and Security Systems

2013 - Springer Science+Business Media | Lecture notes in computer science

Artigo Revisado por pares

Alessio Di Roberto, Mauro Rosi, A. Bertagnini, M. Marani, Fabiano Gamberi, A. Del Principe,

A 4.8 m long gravity core was recovered on a relative topographic high in the northern part of the Marsili Basin (southern Tyrrhenian Sea) at a water depth of 3200 m. The core was taken in order to decipher the sedimentary record of the past volcanic events of the nearby Aeolian arc. A succession of thin (2 cm to 5 cm thick) fine-grained turbidites, mainly of volcaniclastic origin, topped by hemipelagic mud layers and a number of primary tephra layers were recovered by the core. The most prominent ...

Tópico(s): Maritime and Coastal Archaeology

2008 - Elsevier BV | Journal of Volcanology and Geothermal Research

Artigo Revisado por pares

Maria Teresa Giordana, Carla D’Agostino, Giovanni Albani, Alessandro Mauro, Alessio Di Fonzo, Angelo Antonini, Vincenzo Bonifati,

Abstract Leucine‐Rich Repeat Kinase 2 ( LRRK2 ) gene mutations are the most common known cause of Parkinson's disease (PD), but neuropathological studies are available on very few patients with LRRK2 mutation. The reported findings range from Lewy body–positive pathology to different pathologies, including nigral degeneration without distinctive features, neuronal loss with only ubiquitin‐positive inclusions, and tau‐positive–only pathology. Here we report the first neuropathological study in an Italian ...

Tópico(s): Lysosomal Storage Disorders Research

2006 - Wiley | Movement Disorders

Artigo Acesso aberto Revisado por pares

Marco Pistolesi, A. Bertagnini, Alessio Di Roberto, Maurizio Ripepe, Mauro Rosi,

Abstract Devastation associated with tsunamis is well known on the global scale. Flank collapse at volcanic islands is among the mechanisms triggering tsunamis, but very few examples document interaction between landslides and volcanic activity. The study of three well-preserved medieval tsunami deposits recently discovered along the coast of Stromboli volcano (Aeolian Islands, southern Italy) enabled a detailed characterization of the tsunami sequences intercalated with volcaniclastic deposits and ...

Tópico(s): Geology and Paleoclimatology Research

2020 - Geological Society of America | Geology

Artigo Revisado por pares

Daniele D’Agostino, Marco Racioppi, Dario Pugliese, Mauro Ragonese, L. Di Gianfrancesco, Alessio Filianoti, Giuseppe Palermo, E. Belgrano, Salvatore Siracusano, Mauro Niero, Ciro Imbimbo, Massimo Iafrate, Walter Artibani, Maria Angela Cerruto, Renato Talamini, Pierfrancesco Bassi,

<b><i>Background:</i></b> To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. <b><i>Patients and Methods:</i></b> A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for the treatment of bladder cancer. One hundred seventy one patients who underwent radical cystectomy and creation ...

Tópico(s): Ureteral procedures and complications

2016 - Karger Publishers | Urologia Internationalis

Artigo Acesso aberto Revisado por pares

Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore‐Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen R. Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni Cappello, Andrea Bertotti, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Mariangela Russo, Antonella Balsamo, Mauro Truini, Federica Di Nicolantonio, Alessio Amatu, Erica Bonazzina, Silvia Ghezzi, Daniele Regge, Angelo Vanzulli, Livio Trusolino, Salvatore Siena, Silvia Marsoni, Alberto Bardelli,

Targeting HER2 is effective in 24% of ERBB2 amplified metastatic colorectal cancer; however, secondary resistance occurs in most of the cases. We studied the evolution of individual metastases during treatment to discover spatially resolved determinants of resistance. Circulating tumor DNA (ctDNA) analysis identified alterations associated with resistance in the majority of refractory patients. ctDNA profiles and lesion-specific radiographic reports revealed organ- or metastasis-private evolutionary ...

Tópico(s): Genetic factors in colorectal cancer

2018 - Cell Press | Cancer Cell

Artigo Acesso aberto Revisado por pares

Fabiano Gamberi, M. Marani, V. Landuzzi, A. Magagnoli, D. Penitenti, Mauro Rosi, A. Bertagnini, Alessio Di Roberto,

The VST02 cruise carried out in the summer of 2002 was focused at sedimentologic and volcanologic researches over selected areas of the deep portion of the Tyrrhenian sea. Chirp lines and seafloor samples were collected from the Calabrian slope surrounding Stromboli island, in the Marsili deep sea fan, in the Vavilov basin and in the Vavilov seamount. Submarine volcanic activity, both explosive and effusive, is occuring in the Stromboli edifice. Explosive submarine volcanism affects also the shallowest ...

Tópico(s): Methane Hydrates and Related Phenomena

2009 - National Institute of Geophysics and Volcanology | Annals of Geophysics

Artigo Revisado por pares

M. Marani, Fabiano Gamberi, Mauro Rosi, A. Bertagnini, Alessio Di Roberto,

Abstract Stromboli is a 3000 m high island volcano, rising to 900 m above sea‐level. It is the most active volcano of the Aeolian Archipelago in the Tyrrhenian Sea (Italy). Major, large volume (1 km 3 ) sector collapses, four occurring in the last 13 kyr, have played an important role in shaping the north‐western flank (Sciara del Fuoco) of the volcano, potentially generating a high‐risk tsunami hazard for the Aeolian Islands and the Italian coast. However, smaller volume, partial collapses of the Sciara ...

Tópico(s): Landslides and related hazards

2009 - Wiley | Sedimentology

Artigo Revisado por pares

Mauro Provinciali, ALESSIO MONTENOVO, Giuseppina Di Stefano, M. Colombo, Laura Daghetta, Marco Cairati, CLAUDIO VERONI, Roberto Cassino, FABRIZIO DELIA TORRE, Nicola Fabris,

to evaluate whether oral supplementation with zinc or zinc/arginine increases the antibody response to influenza vaccine or modulates the lymphocyte phenotype in elderly subjects.a randomized controlled trial with two supplemented groups and one control group.a community nursing home.384 subjects aged 64-100 (mean age 82 years) examined in three separate studies.oral supplementation with zinc (400 mg/day) or zinc plus arginine (4 g/day) for 60 days starting 15 days before influenza vaccination. The ...

Tópico(s): Child Nutrition and Water Access

1998 - Oxford University Press | Age and Ageing

Artigo Revisado por pares

Elvira Ventura Spagnolo, Cristina Mondello, Debora Di Mauro, Giovanna Vermiglio, Alessio Asmundo, Elena Filippini, Angela Alibrandi, Giuseppina Rizzo,

Tópico(s): Cardiac electrophysiology and arrhythmias

2018 - Springer Science+Business Media | International Journal of Legal Medicine

Revisão Acesso aberto Revisado por pares

Francesca Porcellati, Stefania Di Mauro, Alessio Mazzieri, Alessandra Scamporrino, Agnese Filippello, Michelantonio De Fano, Carmine G. Fanelli, Francesco Purrello, Roberta Malaguarnera, Salvatore Piro,

Hypoglycemia represents a dark and tormented side of diabetes mellitus therapy. Patients treated with insulin or drug inducing hypoglycemia, consider hypoglycemia as a harmful element, which leads to their resistance and lack of acceptance of the pathology and relative therapies. Severe hypoglycemia, in itself, is a risk for patients and relatives. The possibility to have novel strategies and scientific knowledge concerning hypoglycemia could represent an enormous benefit. Novel available glucagon ...

Tópico(s): Diabetes Treatment and Management

2021 - Multidisciplinary Digital Publishing Institute | Biomolecules

Artigo Revisado por pares

Francesca Bartoli, Jelena Blagojević, Marzia Bacci, G. Fiori, Alessio Tempestini, Maria Letizia Conforti, Serena Guiducci, Irene Miniati, MAURO DI CHICCO, Angela Del Rosso, Federico Perfetto, Sergio Castellani, Alberto Moggi Pignone, Marco Matucci‐Cerinic,

Increased evidence suggests an accelerated macrovascular disease in systemic sclerosis (SSc). Brachial artery flow-mediated vasodilation (FMD) and carotid intima-media thickness (IMT) are two indicators of subclinic cardiovascular disease and are frequently used as surrogate measures of subclinic atherosclerosis. The aim of this study was to evaluate macrovascular involvement in SSc. We studied 35 SSc patients (6 males and 29 females; 11 with diffuse and 24 with limited disease) and 20 healthy controls. ...

Tópico(s): Cardiovascular Disease and Adiposity

2007 - Wiley | Annals of the New York Academy of Sciences

Capítulo de livro Revisado por pares

Alessio Di Mauro, Davide Papini, Roberto Vigo, Nicola Dragoni,

Security is a crucial matter for Wireless Sensor Networks. With the recent introduction of Energy-Harvesting nodes, it has gained even more importance. By exploiting the ability of scavenging energy from the surrounding environment, the lifespan of a node has drastically increased. This is one of the reasons why security needs a new take in this topic. Traditional solutions may not work in this new domain. Brand new challenges and threats may arise and new solutions have to be designed. In this ...

Tópico(s): User Authentication and Security Systems

2012 - Springer Science+Business Media | Communications in computer and information science

Artigo Revisado por pares

Alessio Varesano, Fabio Rombaldoni, Cinzia Tonetti, Sandra Di Mauro, Giorgio Mazzuchetti,

ABSTRACT Nanofiber‐coated fabrics have potential uses in filters and protective clothing. One major challenge is to ensure good adhesion of nanofibers to the fabrics achieving satisfactory durability against abrasion for practical use. This work is aimed to study adhesion mechanisms and their improvement between nanofibers and textile substrates; to achieve this goal cotton fabrics were treated with an alkali solution, while nylon fabrics were treated with ethanol. Adhesion of polyamide‐6 electrospun ...

Tópico(s): Conducting polymers and applications

2013 - Wiley | Journal of Applied Polymer Science

Carta Revisado por pares

Mauro Viganò, Antonio Voza, Sergio Harari, Alessandro Eusebio, Marta Ripoll Pons, Marco Bordonali, Vittorio Preti, Maria Grazia Rumi, Salvatore Badalamenti, Alessio Aghemo,

... Vittorio Preti, Maria Grazia Rumi, Salvatore Badalamenti, and Alessio AghemoMauro ViganòAddress correspondence to: Mauro Viganò, MD, PhD, Division of Hepatology, MultiMedica IRCCS, Università di Milano, San Giuseppe Hospital, Via San Vittore 12, ...

Tópico(s): Respiratory Support and Mechanisms

2020 - Mary Ann Liebert, Inc. | Telemedicine Journal and e-Health

Artigo Acesso aberto

Nicola Alessio, Domenico Aprile, Tiziana Squillaro, Giovanni Di Bernardo, Mauro Finicelli, Mariarosa Anna Beatrice Melone, Gianfranco Peluso, Umberto Galderisi,

Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP).There are contrasting studies on the role of the SASP in cancer.Studies suggested that cancer cells may misuse the senescent secretome for their growth.Other investigations evidenced that the SASP may induce cancer growth arrest, senescence, or apoptosis.These conflicting data can be reconciled considering that cancer cells can coax senescent cells ...

Tópico(s): Cytomegalovirus and herpesvirus research

2019 - Impact Journals LLC | Aging

Revisão Acesso aberto Revisado por pares

Giovanni Martinotti, Stefania Chiappini, Mauro Pettorruso, Alessio Mosca, Andrea Miuli, Francesco Di Carlo, Giacomo d’Andrea, Roberta Collevecchio, Ilenia Di Muzio, Stefano L. Sensi, Massimo di Giannantonio,

The obsessive-compulsive spectrum refers to disorders drawn from several diagnostic categories that share core features related to obsessive-compulsive disorder (OCD), such as obsessive thoughts, compulsive behaviors and anxiety. Disorders that include these features can be grouped according to the focus of the symptoms, e.g., bodily preoccupation (i.e., eating disorders, ED) or impulse control (i.e., substance use disorders, SUD), and they exhibit intriguing similarities in phenomenology, etiology, ...

Tópico(s): Neurotransmitter Receptor Influence on Behavior

2021 - Multidisciplinary Digital Publishing Institute | Brain Sciences

Artigo Acesso aberto Revisado por pares

Mauro Mancuso, Serena Di Tondo, Enza Costantini, Alessio Damora, Patrizio Sale, Laura Abbruzzese,

Due to the complexity of the interventions for upper limb recovery, at the moment there is a lack of evidence regarding innovative and effective rehabilitative interventions. Action Observation Training (AOT) constitutes a promising rehabilitative method to improve upper limb motor recovery in stroke patients. The aim of the present study was to evaluate the potential efficacy of AOT, both in upper limb recovery and in functional outcomes when compared to patients treated with task oriented training ( ...

Tópico(s): Balance, Gait, and Falls Prevention

2021 - Multidisciplinary Digital Publishing Institute | Brain Sciences

Artigo Acesso aberto Revisado por pares

Francesca Martini, A. D’Alessio, Federico Bracchi, Daniela Di Mauro, Anna Fargnoli, Marco Motta, Cristina Giussani, Marco Meazza Prina, Giovanni Gobbin, Monica Taverna,

Background The use of computed tomography (CT) for coronavirus disease 2019 (COVID-19) diagnosis in an area of northern Italy with a high incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have identified more patients with this disease than RT-PCR in the very early onset of the COVID-19 pandemic. Methods We retrospectively reviewed 148 chest CT scans of oncological patients who were referred to the Radiological Unit of Policlinico S. Marco from 1 February 2020 ...

Tópico(s): Ultrasound in Clinical Applications

2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine

Revisão Acesso aberto Revisado por pares

Fabrizio Schifano, Stefania Chiappini, Andrea Miuli, Alessio Mosca, Maria Chiara Santovito, John Corkery, Amira Guirguis, Mauro Pettorruso, Massimo di Giannantonio, Giovanni Martinotti,

Background: Over the past 20 years or so, the drug misuse scenario has seen the emergence of both prescription-only and over-the-counter (OTC) medications being reported as ingested for recreational purposes. OTC drugs such as antihistamines, cough/cold medications, and decongestants are reportedly the most popular in being diverted and misused. Objective: While the current related knowledge is limited, the aim here was to examine the published clinical data on OTC misuse, focusing on antihistamines ( ...

Tópico(s): Poisoning and overdose treatments

2021 - Frontiers Media | Frontiers in Psychiatry

Artigo Revisado por pares

Nicola Coluccelli, Alessio Gambetta, Davide Gatti, Marco Marangoni, A. Di Lieto, Mauro Tonelli, G. Galzerano, P. Laporta,

A high-power optical frequency comb at 2.06 μm has been generated using a Ho:YLF multipass amplifier seeded by the long wavelength supercontinuum tail of an octave-spanning Er:fiber comb source. The Ho:YLF amplifier showed a net gain larger than 30 dB from 2048 to 2068 nm, allowing the generation of a 20 nm bandwidth comb with a mode spacing of 100 MHz and a power per mode ranging from 20 to 370 μW. In the time domain, the amplified comb corresponds to a pulse train with 1.6 W total power and 508 ...

Tópico(s): Photonic Crystal and Fiber Optics

2011 - Optica Publishing Group | Optics Letters

Artigo Acesso aberto Revisado por pares

Lucia Taramasso, Francesco Liggieri, Giovanni Cenderello, Francesca Bovis, Barbara Giannini, Alessio Mesini, Mauro Giacomini, Giovanni Cassola, Claudio Viscoli, Antonio Di Biagio,

Abstract Retrospective multicentre study aiming at analysing the etiology, characteristics and outcome of bloodstream infections (BSI) in people living with HIV (PLWHIV) in an era of modern antiretroviral therapy. Between 2008 and 2015, 79 PLWHIV had at least 1 BSI, for a total of 119 pathogens isolated. Patients were mainly male (72.1%), previous intravenous drug users (55.7%), co-infected with HCV or HBV (58.2%) and in CDC stage C (60.8%). Gram-positive (G+) pathogens caused 44.5% of BSI, followed by ...

Tópico(s): Antibiotic Resistance in Bacteria

2019 - Nature Portfolio | Scientific Reports

Artigo Revisado por pares

Marco Simiele, Lorena Baietto, Alessio Audino, Mauro Sciandra, Stefano Bonora, Giovanni Di Perri, Antonio D’Avolio,

Maraviroc is a CCR5 inhibitor approved in 2007 for treatment of therapy experienced adult patients infected with CCR5-tropic HIV-1 virus. International guidelines for HIV therapy indicate a plasma concentration cutoff of maraviroc for response. We developed and validated a new HPLC-MS method to quantify maraviroc concentrations in human plasma. 6,7-Dimethyl-2,3-di(2-pyridyl)quinoxaline was used as internal standard and added to 100μL of plasma. Samples were then treated with 500μL of acetonitrile ...

Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment

2014 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis

Artigo Acesso aberto Revisado por pares

Vittorio Fineschi, Anna Aprile, Isabella Aquila, Mauro Arcangeli, Alessio Asmundo, Mauro Bacci, Mariano Cingolani, Luigi Cipolloni, Stefano D’Errico, Ilaria De Casamassimi, Giulio Di Mizio, Marco Di Paolo, Martina Focardi, Paola Frati, Mario Gabbrielli, Raffaele La Russa, Aniello Maiese, Federico Manetti, Massimo Martelloni, E. Mazzeo, Angelo Montana, Margherita Neri, Martina Padovano, Vilma Pinchi, Cristoforo Pomara, Pietrantonio Ricci, Monica Salerno, Alessandro Santurro, Matteo Scopetti, Roberto Testi, Emanuela Turillazzi, Giuseppe Vacchiano, Filippo Crivelli, Emanuela Bonoldi, Fabio Facchetti, Manuela Nebuloni, Anna Sapino,

The COVID-19 (Coronavirus Disease-19) is the most urgent health emergency worldwide and all professionals are called to give support in the diagnosis and treatment of patients affected by this disease. The Scientific Society of Hospital Legal Medicine of the National Health System (COMLAS) and the Italian Society of Anatomical Pathology and Cytology (SIAPEC) produced this document with the intent of offering a technical support to professional involved in the autoptic activities during the Severe Acute ...

Tópico(s): Body Image and Dysmorphia Studies

2020 - Pacini Editore | Pathologica

Capítulo de livro Acesso aberto Revisado por pares

L. Pioli, Mauro Rosi, Sonia Calvari, Letizia Spampinato, Alberto Renzulli, Alessio Di Roberto,

This chapter contains sections titled: Introduction Methods Results Data Interpretation Conclusions

Tópico(s): Geological and Geochemical Analysis

2011 - American Geophysical Union | Geophysical monograph