V. P. Kutyshenko, Galina V. Mikoulinskaia, Sergei V. Chernyshov, Alexander Y. Yegorov, Dmitry A. Prokhorov, Vladimir N. Uversky,
In this work, we studied the effect of the C-terminally attached poly-histidine tag (His-tag), as well as the peculiarities of the protein purification procedure by the immobilized metal affinity chromatography (IMAC) on the activity and structure of the metalloenzyme, l-alanyl-d-glutamate peptidase of bacteriophage T5 (EndoT5), whose zinc binding site and catalytic aspartate are located near the C-terminus. By itself, His-tag did not have a significant effect on either activity or folding of the polypeptide ...
Tópico(s): Enzyme Structure and Function
2018 - Elsevier BV | International Journal of Biological Macromolecules
Elena O. Levina, Ivan Yu. Chernyshov, Alexander P. Voronin, Л. Н. Алексейко, A.I. Stash, Mikhail V. Vener,
The nature and strength of weak interactions with organic fluorine in the solid state are revealed by periodic density functional theory (periodic DFT) calculations coupled with experimental data on the structure and sublimation thermodynamics of crystalline organofluorine compounds. To minimize other intermolecular interactions, several sets of crystals of perfluorinated and partially fluorinated organic molecules are considered. This allows us to establish the theoretical levels providing an adequate ...
Tópico(s): Crystallography and molecular interactions
2019 - Royal Society of Chemistry | RSC Advances
Alexander A. Kolganov, Anton A. Gabrienko, Ivan Yu. Chernyshov, Alexander G. Stepanov, Evgeny A. Pidko,
The influence of the model and method choice on the DFT predicted 13C NMR chemical shifts of zeolite surface methoxide species has been systematically analyzed. Twelve 13C NMR chemical shift calculation protocols on full periodic and hybrid periodic-cluster DFT calculations with varied structural relaxation procedures are examined. The primary assessment of the accuracy of the computational protocols has been carried out for the Si-O(CH3)-Al surface methoxide species in ZSM-5 zeolite with well-defined ...
Tópico(s): Zeolite Catalysis and Synthesis
2020 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Alexander A. Kolganov, Anton A. Gabrienko, Ivan Yu. Chernyshov, Alexander G. Stepanov, Evgeny A. Pidko,
The reactivity theories and characterization studies for metal-containing zeolites are often focused on probing the metal sites. We present a detailed computational study of the reactivity of Zn-modified BEA zeolite towards C-H bond activation of the methane molecule as a model system that highlights the importance of representing the active site as the whole reactive ensemble integrating the extra-framework ZnEF2+ cations, framework oxygens (OF2-), and the confined space of the zeolite pores. We ...
Tópico(s): Polyoxometalates: Synthesis and Applications
2022 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Oleg A. Drozhzhin, V. V. Grigoryev, Anastasia M. Alekseeva, Ruslan R. Samigullin, Dmitry A. Aksyonov, Olga V. Boytsova, D. Chernyshov, В. В. Шаповалов, Alexander A. Guda, А. В. Солдатов, Keith J. Stevenson, Artem M. Abakumov, Evgeny V. Antipov,
Ti2Nb2O9 with a tunnel-type structure is considered as a perspective negative electrode material for Li-ion batteries (LIBs) with theoretical capacity of 252 mAh g-1 corresponding to one-electron reduction/oxidation of Ti and Nb, but only ≈160 mAh g-1 has been observed practically. In this work, highly reversible capacity of 200 mAh g-1 with the average (de)lithiation potential of 1.5 V vs Li/Li+ is achieved for Ti2Nb2O9 with pseudo-2D layered morphology obtained via thermal decomposition of the NH4TiNbO5 ...
Tópico(s): Advanced Battery Materials and Technologies
2021 - American Chemical Society | ACS Applied Materials & Interfaces
S A Goryaynov, Georg Widhalm, Maria Goldberg, D M Chelushkin, Aldo Spallone, Kosta A. Chernyshov, Marina Ryzhova, Galina Pavlova, Alexander Revischin, Ludmila Shishkina, Vadim Jukov, Tatiana A. Savelieva, Loschenov Victor, Potapov Aa,
Objectives: Intraoperative tumor visualization with 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is widely applied for improved resection of high-grade gliomas. However, visible fluorescence is present only in a minority of low-grade gliomas (LGGs) according to current literature. Nowadays, antiepileptic drugs (AEDs) are frequently administered to LGG patients prior to surgery. A recent in-vitro study demonstrated that AEDs result in significant reduction of PpIX synthesis ...
Tópico(s): Photodynamic Therapy Research Studies
2019 - Frontiers Media | Frontiers in Oncology
Ivan Yu. Chernyshov, Mikhail V. Vener, Petr V. Prikhodchenko, Alexander G. Medvedev, Ovadia Lev, Andrei V. Churakov,
The Cambridge Structural Database has been used to investigate the detailed environment of H2O2 molecules and hydrogen-bond patterns within "true" peroxosolvates in which the H2O2 molecules do not interact directly with the metal atoms. A study of 65 crystal structures and over 260 hydrogen bonds reveals that H2O2 always forms two H-bonds as proton donors and up to four H-bonds as a proton acceptor, but the latter can be absent altogether. The necessary features of peroxosolvate coformers are clarified. ( ...
Tópico(s): Vanadium and Halogenation Chemistry
2016 - American Chemical Society | Crystal Growth & Design
S A Goryaynov, V A Okhlopkov, D A Gol'bin, Konstantin A. Chernyshov, Dmitrij V. Svistov, Б. В. Мартынов, Alexander Kim, Vadim A. Byvaltsev, Galina Pavlova, А. И. Баталов, Н. А. Коновалов, Petr Zelenkov, Victor B. Loschenov, Alexandr Potapov,
The objective of this study is to analyze fluorescence sensitivity in diagnosis of brain and spinal cord tumors. Material and methods. The authors conducted a multicenter retrospective analysis of 653 cases in 641 patients: 553 of them had brain tumors, and 88 spinal cord tumors. Brain tumor resection was performed in 523 patients, of whom 484 were adults and 39 children. The analyzed series was presented by 320 gliomas, 101 meningiomas and 72 metastases. Stereotactic biopsy was performed in 20 ...
Tópico(s): Nanoplatforms for cancer theranostics
2019 - Frontiers Media | Frontiers in Oncology
Igor I. Slukvin, Chernyshov Vp, Alena A. Merkulova, Maxim A. Vodyanik, Alexander K. Kalinovsky,
Decidual and peripheral blood lymphocyte subsets were studied for their expression of CD44, L-selectin (Leu-8), CD54, and CD11b cell adhesion molecules (CAM). Most CD3+, CD4+, CD8+, and CD56+ cells in decidua were L-selectin- and CD44+, i.e., had a phenotype consistent with mucosa-homing preference of decidual lymphocytes (DL). We observed trimodal staining of decidual and peripheral blood CD56+ and CD8+ cells with anti-CD44 monoclonal antibody; negative, weakly positive, and brightly positive subpopulations ...
Tópico(s): Pregnancy-related medical research
1994 - Elsevier BV | Cellular Immunology
Hannah Wecker, Linda Tizek, Stefanie Ziehfreund, Alphina Kain, Claudia Traidl‐Hoffmann, G. Zimmermann, Emanuele Scala, Jesper Elberling, Anaïs Doll, Michael J. Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, Natalia Ballardini, Pavel V. Chernyshov, Jeroen Buters, Tilo Biedermann, Alexander Zink,
Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior.The study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest.Google Ads Keyword Planner was used to measure search volume for search terms related ...
Tópico(s): Health Literacy and Information Accessibility
2023 - Elsevier BV | World Allergy Organization Journal
Sergey V. Ovsyannikov, Maxim Bykov, Sergey A. Medvedev, Pavel G. Naumov, Anton Jesche, Alexander A. Tsirlin, Elena Bykova, Irina Chuvashova, Alexander E. Karkin, Vadim Dyadkin, D. Chernyshov, Leonid Dubrovinsky,
Abstract Functional oxides whose physicochemical properties may be reversibly changed at standard conditions are potential candidates for the use in next‐generation nanoelectronic devices. To date, vanadium dioxide (VO 2 ) is the only known simple transition‐metal oxide that demonstrates a near‐room‐temperature metal–insulator transition that may be used in such appliances. In this work, we synthesized and investigated the crystals of a novel mixed‐valent iron oxide with an unconventional Fe 5 O 6 ...
Tópico(s): Multiferroics and related materials
2020 - Wiley | Angewandte Chemie International Edition
Alexander G. Medvedev, Alexey A. Mikhaylov, Ivan Yu. Chernyshov, Mikhail V. Vener, Ovadia Lev, Petr V. Prikhodchenko,
Abstract The adsorption of a single H 2 O 2 or H 2 O molecule on a family of periodic slab models of γ‐AlOOH is studied by solid‐state DFT. The single H 2 O 2 or Н 2 О molecule interacts with the perfect (010) slab by intermolecular hydrogen bonds (H‐bonds). In the models of γ‐AlOOH with oxygen and aluminum vacancies, H 2 O 2 or Н 2 О also forms covalent O∙∙∙Al bonds. The energies of covalent O∙∙∙Al and H‐bonds are estimated by a combined approach based on simultaneous consideration of the total binding ...
Tópico(s): Crystallography and molecular interactions
2019 - Wiley | International Journal of Quantum Chemistry
Ivan Yu. Chernyshov, Vitalij V. Levin, Alexander D. Dilman, Pavel A. Belyakov, Марина И. Стручкова, Vladimir A. Tartakovsky,
Tópico(s): Asymmetric Synthesis and Catalysis
2010 - Springer Science+Business Media | Russian Chemical Bulletin
Hannah Wecker, Stefanie Ziehfreund, Sebastian Sitaru, Emma Johansson, Jesper Elberling, Anaïs Doll, Electra Nicolaidou, Emanuele Scala, Michael J. Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, Pavel V. Chernyshov, Alexander Zink,
Abstract Background The complexity, high prevalence, and substantial personal and socioeconomic burden collectively render atopic dermatitis (AD) a major public health concern. Using crowdsourced Internet data has the potential to provide unique insights into this concern, as demonstrated by several previous studies. However, a comprehensive comparison across European countries remains lacking. Objectives The study aimed to investigate AD‐related web searches across Europe to assess spatiotemporal ...
Tópico(s): Asthma and respiratory diseases
2024 - Wiley | Journal of the European Academy of Dermatology and Venereology
А. А. Чернышов, K. V. Karelsky, A. S. Petrosyan, G. Bertin, Franca De Luca, Giuseppe Lodato, R. Pozzoli, M. Romé,
... and Permissions Cite Icon Cite Search Site Citation Alexander A. Chernyshov, Kirill V. Karelsky, Arakel S. Petrosyan; Weakly compressible ...
Tópico(s): Meteorological Phenomena and Simulations
2010 - American Institute of Physics | AIP conference proceedings
S. V. Grigoriev, Kirill S. Napolskii, N. A. Grigoryeva, A. V. Vasilieva, А. А. Мистонов, D. Chernyshov, Andrei V. Petukhov, Д. В. Белов, А. А. Елисеев, A. V. Lukashin, Yu. D. Tret’yakov, Alexander Sinitskii, H. Eckerlebe,
The structural and magnetic properties of nickel inverse opal photonic crystal have been studied by complementary experimental techniques, including scanning electron microscopy, wide-angle and small-angle diffraction of synchrotron radiation, and polarized neutrons. The sample was fabricated by electrochemical deposition of nickel in voids in a colloidal crystal film made of 450 nm polystyrene microspheres followed by their dissolving in toluene. The microradian small-angle diffraction of synchrotron ...
Tópico(s): Thermal Radiation and Cooling Technologies
2009 - American Physical Society | Physical Review B
Yu Wang, Konstantin Glazyrin, Valery V. Roizen, Artem R. Oganov, Ivan Yu. Chernyshov, Xiao Zhang, Eran Greenberg, Vitali B. Prakapenka, Xue Yang, Shuqing Jiang, Alexander F. Goncharov,
We report a new hydrogen clathrate hydrate synthesized at 1.2 GPa and 298 K documented by single-crystal X-ray diffraction, Raman spectroscopy, and first-principles calculations. The oxygen sublattice of the new clathrate hydrate matches that of ice II, while hydrogen molecules are in the ring cavities, which results in the trigonal R3c or R-3c space group (proton ordered or disordered, respectively) and the composition of (H2O)6H2. Raman spectroscopy and theoretical calculations reveal a hydrogen ...
Tópico(s): Inorganic Fluorides and Related Compounds
2020 - American Physical Society | Physical Review Letters
В. И. Марчук, D. Chernyshov, Ilya Sadrtdinov, Alexander Minaev,
The paper presents the results of the studies of the probability of a “flip” of the approximating function when processing the measurement results under conditions of a priori uncertainty about the signal function and the statistical characteristics of additive noise. It is analytically proved that the confidence intervals of the probability of the absence and the presence of a “flip” are equal, which is confirmed by the experimental results. The dependences of the “flipping” of the approximating function ...
Tópico(s): Scientific Measurement and Uncertainty Evaluation
2019 - EDP Sciences | E3S Web of Conferences
Quentin Guesnay, Charles J. McMonagle, D. Chernyshov, Waqas Zia, Alexander Wieczorek, Sebastian Siol, Michael Saliba, Christophe Ballif, Christian Wolff,
High-vacuum, single-source thermal evaporation is an appealing deposition process for perovskite photovoltaics. It promises the homogeneous and precisely controlled growth of very pure and homogeneous films on large areas in a conformal way. In this work, we study mechanically synthesized substoichiometric cesium bromide–lead iodide precursors, the single-source evaporation of the resulting mixes, subsequent deposited metal halide thin films, and converted perovskite thin films. Diffraction pattern ...
Tópico(s): Optical properties and cooling technologies in crystalline materials
2023 - American Chemical Society | ACS Photonics
Alexander Danilovich Chernyshov, Vitalij Valer'evich Goryajnov,
We studied the relative error of representation functions and their derivatives rapid expansions of sine and cosine expansion.Based on the analysis of data obtained by the condition of numerical experiments to determine the number of members of the rapid expansion required to represent smooth functions rapid expansion with relative error calculation is not more than 1%.
Tópico(s): Graph theory and applications
2016 - International Academy Of Theoretical & Applied Science | Theoretical & Applied Science
В. А. Постников, Yaroslav Odarchenko, A.V. Iovlev, Vladimir V. Bruevich, Alexander Yu. Pereverzev, L.G. Kudryashova, V.V. Sobornov, Loı̈c Vidal, D. Chernyshov, Yuriy N. Luponosov, Oleg V. Borshchev, Nikolay M. Surin, Sergey A. Ponomarenko, Dimitri A. Ivanov, Dmitry Yu. Paraschuk,
Single crystals of thiophene–phenelyne co-oligomers (TPCOs) have previously shown their potential for organic optoelectronics. Here we report on solution growth of large-area thin single-crystalline films of TPCOs at the gas–liquid interface by using solvent–antisolvent crystallization, isothermal slow solvent evaporation, and isochoric cooling. The studied co-oligomers contain identical conjugated core (5,5′-diphyenyl-2,2′-bithiophene) and different terminal substituents, fluorine, trimethylsilyl, ...
Tópico(s): Luminescence and Fluorescent Materials
2014 - American Chemical Society | Crystal Growth & Design
N.S. Bofanova, Alexander Yu. Tychkov, A. V. Dyatlov, D.S. Chernyshov, A.P. Nazarychev,
ЦЕЛЬ ИССЛЕДОВАНИЯ Хроническая боль — актуальный мультидисциплинарный вопрос и важная медико-социальная проблема, которая оказывает влияние на трудоспособность и качество жизни пациентов, их физическое и психическое здоровье. С 1 января 2022 г. официально вступает в силу Международная классификация болезней 11-го пересмотра (МКБ-11), в которой появляется новая дефиниция: «хроническая послеоперационная или посттравматическая боль». Новая классификация предполагает поиск современных направлений в реабилитации ...
Tópico(s): Pain Management and Treatment
2022 - | Russian Journal of Pain
Pavel V. Chernyshov, L. Tomás-Aragonés, L. Manolache, Nives Pustišek, Carmen Sălăvăstru, S.E. Marrón, Anthony Bewley, Åke Svensson, F. Poot, Alina Suru, Sam Salek, Matthias Augustin, Jacek C. Szepietowski, Dimitra Koumaki, Alexander Katoulis, Francesca Sampogna, Damiano Abeni, Dennis Linder, Reinhart Speeckaert, Nanja van Geel, Julien Séneschal, Khaled Ezzedine, A.Y. Finlay,
Members of the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life (QoL) and Patient Oriented Outcomes reviewed the instruments available for health-related (HR) QoL assessment in vitiligo and together with external vitiligo experts (including representatives of the EADV Vitiligo Task Force) have made practical recommendations concerning the assessment of QoL in vitiligo patients. The Dermatology Life Quality Index (DLQI) was the most frequently used HRQoL instrument, ...
Tópico(s): Skin Protection and Aging
2022 - Wiley | Journal of the European Academy of Dermatology and Venereology
Hannah Wecker, Stefanie Ziehfreund, Sebastian Sitaru, Emma Johansson, Jesper Elberling, Anaïs Doll, Electra Nicolaidou, Emanuele Scala, Michael J. Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, Pavel V. Chernyshov, Alexander Zink,
... of each country. Hannah Wecker, Stefanie Ziehfreund, and Alexander Zink conceptualised the study and provided the first draft. Hannah Wecker performed the statistical analysis. Sebastian Sitaru, Emma K. Johansson, Jesper Elberling, Anaïs Doll, Electra Nicolaidou, Emanuele Scala, Michael J. Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, and Pavel V. Chernyshov provided data and actively contributed to discussion of ...
Tópico(s): Dermatology and Skin Diseases
2024 - Springer Science+Business Media | Clinical and Translational Allergy
D.S. Chernyshov, Alexander Yu. Tychkov, O. S. Simakova, Aleksandr Ivanov, Dmitry L. Ovchinnikov, V. N. Gorbunov, Alan K. Alimuradov,
Tópico(s): Context-Aware Activity Recognition Systems
2025 - Springer Science+Business Media | Biomedical Engineering
В. И. Марчук, Igor Shrafel, D. Chernyshov, Alexander Minaev, Stepan Buryakov,
The paper provides an analytical proof the optimal number of partitions of a non-stationary random process realization, which is necessary for estimating its expected value when using ?the estimation reproduction? method for signal processing. This method allows to process signal with a limited volume of priori information about the desired signal function and statistical characteristics of the additive noise component.
Tópico(s): Fault Detection and Control Systems
2017 - Faculty of Technical Sciences in Cacak | Serbian Journal of Electrical Engineering
Dmitrii Grachev, Danil Ivanov, Vladimir Kushnarev, Sheila T. Yong, Nikita Kotlov, Konstantin Chernyshov, Alexander Bagaev, Nathan Fowler, Anthony P. Conley, Gregory M. Coté, Sant P. Chawla,
11523 Background: Despite the evolution of therapeutic strategies for sarcomas in the past four decades, survival in the metastatic setting remains poor. This underscores the urgent need to explore new diagnostic and treatment avenues to improve patient outcomes. Harnessing the capability of RNA sequencing (RNA-seq) to detect gene fusions de-novo, we analyzed treated bone sarcoma samples with the aim to uncover gene fusions and breakpoints that are potentially relevant as clinical biomarkers and ...
Tópico(s): Sarcoma Diagnosis and Treatment
2024 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Jiahui Su, Yuri Mazei, Andrey N. Tsyganov, Viktor Chernyshov, Alexander A Komarov, E. A. Malysheva, Kirill V. Babeshko, Natalia Mazei, Damir Saldaev, Boris Levin, Basil N. Yakimov,
The functional traits of soil protists have been employed in ecological research to enhance comprehension of the underlying mechanisms of ecological processes. Among the numerous soil protists, testate amoebae emerge as a prominent and abundant group, playing a pivotal role in soil micro-food webs. Furthermore, they are regarded as valuable bioindicators for environmental monitoring and palaeoecological studies due to their sensitivity to environmental changes. We screened 372 testate amoebae species ...
Tópico(s): Planetary Science and Exploration
2024 - Nature Portfolio | Scientific Data
D.S. Chernyshov, Alexander Yu. Tychkov, Sofya Yu. Tverskaya, Alan K. Alimuradov, O. S. Simakova,
Tópico(s): Neural and Behavioral Psychology Studies
2024 - Springer Science+Business Media | Biomedical Engineering
А. М. Балагуров, И.А. Бобриков, D. Chernyshov, Alexander Sohatsky, S.V. Sumnikov, B. Yerzhanov, I.S. Golovin,
Tópico(s): Electric Motor Design and Analysis
2024 - American Physical Society | Physical Review Materials