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Artigo Acesso aberto Revisado por pares

Aleksey Suvorov, Alexander Gusev, Mikhail Andreev, Alisher Askarov,

Reliability and efficiency of electric power systems (EPS) operation depend on the adequacy of information about quasi-state and transient processes in EPS used for their research, design, and operation. A value of short-circuit currents (SCC), especially their maximum values, is one of the important information used for different tasks. The difficulty of obtaining this information is the need to use a large-scale EPS mathematical model for SCC calculation. The total mathematical model of any large- ...

Tópico(s): Real-time simulation and control systems

2020 - Wiley | International Transactions on Electrical Energy Systems

Revisão Acesso aberto Revisado por pares

Alexander Suvorov, Larissa Takser,

A well-documented fact for a group of persistent, bioaccumulating organohalogens contaminants, namely polychlorinated biphenyls (PCBs), is that appropriate regulation was delayed, on average, up to 50 years. Some of the delay may be attributed to the fact that the science of toxicology was in its infancy when PCBs were introduced in 1920's. Nevertheless, even following the development of modern toxicology this story repeats itself 45 years later with polybrominated diphenyl ethers (PBDEs) another ...

Tópico(s): Carcinogens and Genotoxicity Assessment

2008 - BioMed Central | Environmental Health

Artigo Revisado por pares

Aleksey Suvorov, Alexander Gusev, Nikolay Ruban, Mikhail Andreev, Alisher Askarov, Ruslan Ufa, Igor Razzhivin, Аnton Kievets, Julius Bay,

Abstract Currently, the number of distributed generation (DG) objects in the world is growing mainly due to renewable energy sources (RES). However, the integration of a large volume of DG based on RES into existing electric power systems (EPS) is associated with a number of significant problems. For a comprehensive study and solution of these problems, it is necessary to carry out detailed simulation of real EPS, which is not always feasible with the help of existing tools. Therefore, the article ...

Tópico(s): Electric Power Systems and Control

2019 - De Gruyter | International Journal of Emerging Electric Power Systems

Artigo

Richard Andrews,

... Crossref reports the following articles citing this article:Alexander Suvorov Population Numbers and Reproductive Health, Endocrinology 162, no. ...

Tópico(s): thermodynamics and calorimetric analyses

1968 - University of Chicago Press | Physiological Zoology

Artigo Acesso aberto Revisado por pares

Alexander Suvorov, Larissa Takser,

BackgroundPolybrominated diphenyl ethers are a group of flame-retardant chemicals appearing increasingly in the environment. Their health effects and mechanisms of toxicity are poorly understood.ObjectivesWe screened for the sensitive effects and mechanisms of toxicity of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by analyzing the gene expression profile in rats exposed to doses comparable to human exposure.MethodsWistar dams were exposed to vehicle or BDE-47 (0.002 and 0.2 mg/kg body weight) every ...

Tópico(s): Effects and risks of endocrine disrupting chemicals

2009 - National Institute of Environmental Health Sciences | Environmental Health Perspectives

Artigo Acesso aberto Revisado por pares

Nadia Abdelouahab, Guy Huel, Alexander Suvorov, B. Foliguet, Valérie Goua, Ginette Debotte, Josianne Sahuquillo, Marie‐Aline Charles, Larissa Takser,

Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. The study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium ( ...

Tópico(s): Trace Elements in Health

2009 - Elsevier BV | Neurotoxicology and Teratology

Artigo Revisado por pares

Nadia Abdelouahab, Alexander Suvorov, Jean‐Charles Pasquier, Marie‐France Langlois, Jean‐Paul Praud, Larissa Takser,

The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 μg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T<sub>4</ ...

Tópico(s): Per- and polyfluoroalkyl substances research

2009 - Karger Publishers | Neonatology

Artigo Revisado por pares

Alexander Suvorov, Marie‐Claude Battista, Larissa Takser,

Polybrominated diphenyl ethers (PBDEs) are a group of environmental contaminants increasing in North America. Few data are available on their growth effects at low doses exposure. Our goal in the present study was to evaluate whether low doses of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), which is the most abundant PBDE found in human samples, affects growth and insulin-like growth factor 1 (IGF-1). Dams were exposed either to the vehicle or low doses of BDE-47 (0.002 and 0.2 mg/kg body weight) every ...

Tópico(s): Toxic Organic Pollutants Impact

2009 - Elsevier BV | Toxicology

Artigo Revisado por pares

Alexander Suvorov, Larissa Takser,

ABSTRACT BDE‐47 is the most prevalent congener of polybrominated diphenyl ethers, which are widely used flame retardants, and is known for endocrine and behavioral disrupting properties in animals. Transient effect on spontaneous motor activity in rats following perinatal exposure to BDE‐47 at low doses, relevant to human exposure, was reported in our previous study. The objective of this study was to screen for the long‐term effects on gene expression in the brain of rats perinatally exposed to ...

Tópico(s): Carcinogens and Genotoxicity Assessment

2011 - Wiley | Journal of Applied Toxicology

Artigo Acesso aberto Revisado por pares

Mary C. Catanese, Alexander Suvorov, Laura N. Vandenberg,

Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.

Tópico(s): Carcinogens and Genotoxicity Assessment

2014 - Oxford University Press | Toxicology Research

Artigo Acesso aberto Revisado por pares

Kerri Stanley Yip, Alexander Suvorov, Jeannette Connerney, Nicholas J Lodato, David J. Waxman,

Changes in the CD-1 mouse uterine transcriptome during proestrus and estrus were investigated to help elucidate mechanisms of uterine tissue remodeling during the estrus cycle and their regulation by estrogen and progesterone in preparation of the uterus for pregnancy. Mice were staged beginning at 6 weeks of age, and uterine horns were harvested after monitoring two estrus cycles. Microarray analysis of whole uterine horn RNA identified 2428 genes differentially expressed in estrus compared to ...

Tópico(s): RNA Research and Splicing

2013 - Oxford University Press | Biology of Reproduction

Artigo Revisado por pares

Rachel Wood, Thomas Higham, A Buzilhova, Alexander Suvorov, Jan Heinemeier, Jesper Olsen,

If ancient carbon is incorporated into lakes and rivers, it can be transferred along the foodchain where it can cause radiocarbon dates to appear erroneously old. This effect is known as the 14 C freshwater reservoir effect (FRE), and causes particular problems when dating human remains. Several studies have attempted to use carbon and/or nitrogen stable isotopes to predict the size of the FRE, with mixed success. We have examined whether the FRE at the Mesolithic-Neolithic burial ground of Minino, ...

Tópico(s): Pleistocene-Era Hominins and Archaeology

2013 - Cambridge University Press | Radiocarbon

Artigo Revisado por pares

Rachel Wood, Thomas Higham, A Buzilhova, Alexander Suvorov, Jan Heinemeier, Jesper Olsen,

If ancient carbon is incorporated into lakes and rivers, it can be transferred along the foodchain where it can cause radiocarbon dates to appear erroneously old. This effect is known as the 14 C freshwater reservoir effect (FRE), and causes particular problems when dating human remains. Several studies have attempted to use carbon and/or nitrogen stable isotopes to predict the size of the FRE, with mixed success. We have examined whether the FRE at the Mesolithic-Neolithic burial ground of Minino, ...

Tópico(s): Isotope Analysis in Ecology

2013 - Cambridge University Press | Radiocarbon

Artigo Acesso aberto Revisado por pares

Benjamin Kim, Eliezer Colon, Shivansh Chawla, Laura N. Vandenberg, Alexander Suvorov,

In humans, the causal link between socioeconomic status (SES) and body weight (BW) is bidirectional, as chronic stress associated with low SES may increase risk of obesity and excess weight may worsen career opportunities resulting in lower SES. We hypothesize that environmental factors affecting BW and/or social stress might reprogram physiological and social trajectories of individuals.To analyze interactions between BW and social behaviors in mice perinatally exposed to one of several environmental ...

Tópico(s): Stress Responses and Cortisol

2015 - BioMed Central | Environmental Health

Artigo Acesso aberto Revisado por pares

Jerrold J. Heindel, Frederick S. vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A. Cohn, Elena Fabbri, Laura Gioiosa, Christopher D. Kassotis, Juliette Legler, Michele A. La Merrill, Laura Rizzir, Ronit Machtinger, Alberto Mantovani, Michelle A. Méndez, Luisa Montanini, Laura Molteni, Susan C. Nagel, Stefano Parmigiani, Giancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T. Schug, Maria Elisabeth Street, Alexander Suvorov, Riccardo Volpi, R. Thomas Zoeller, Paola Palanza,

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16–18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as “metabolic disruptors”, in obesity and metabolic syndrome with special attention to recent discoveries from ...

Tópico(s): Nutritional Studies and Diet

2015 - BioMed Central | Environmental Health

Editorial Acesso aberto Revisado por pares

Haruki Kitazawa, Susana Alvarez, А. Н. Суворов, Vyacheslav G. Melnikov, Julio Villena, Borja Sánchez,

... mechanisms of probiotic actions. Haruki Kitazawa Susana Alvarez Alexander Suvorov Vyacheslav Melnikov Julio Villena Borja Sanchez

Tópico(s): Clostridium difficile and Clostridium perfringens research

2015 - Hindawi Publishing Corporation | BioMed Research International

Revisão Acesso aberto Revisado por pares

Alexander Suvorov, David J. Waxman,

Exposure to Bisphenol A (BPA) during the critical window of uterine development has been proposed to program the uterus for increased disease susceptibility based on well-documented effects of the potent xenoestrogen diethylstilbestrol. To investigate this proposal, we reviewed 37 studies of prenatal and/or perinatal BPA exposure in animal models and evaluated evidence for: molecular signatures of early BPA exposure; the development of adverse uterine health effects; and epigenetic changes linked ...

Tópico(s): Toxic Organic Pollutants Impact

2015 - Elsevier BV | Reproductive Toxicology

Artigo Acesso aberto Revisado por pares

Valery Filatov, Alexander Suvorov,

This article presents a technique to describe the stress-strain state of the normal section of reinforced concrete beams using nonlinear deformation model. An algorithm of describing the section operation built with the use of mathematical apparatus in the «MathCAD» environment. This algorithm allowed details to consider the state of stress of the normal section on the basis of stepper-iterative and integrated processes using real materials deformation diagrams. During algorithmization of section ...

Tópico(s): Advanced Energy Technologies and Civil Engineering Innovations

2016 - Elsevier BV | Procedia Engineering

Revisão Acesso aberto Revisado por pares

Alexander Suvorov, Laura N. Vandenberg,

The power of animal models is derived from the ability to control experimental variables so that observed effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this variability, artificial equalization of the number of offspring in a litter (culling) is often used. The rationale for culling, however, has always been controversial. The Developmental ...

Tópico(s): Toxic Organic Pollutants Impact

2016 - Oxford University Press | Endocrinology

Artigo Acesso aberto Revisado por pares

Dana Lau-Corona, Alexander Suvorov, David J. Waxman,

Sex-dependent pituitary growth hormone (GH) secretory profiles—pulsatile in males and persistent in females—regulate the sex-biased, STAT5-dependent expression of hundreds of genes in mouse liver, imparting sex differences in hepatic drug/lipid metabolism and disease risk. Here, we examine transcriptional and epigenetic changes induced by continuous GH infusion (cGH) in male mice, which rapidly feminizes the temporal profile of liver STAT5 activity. cGH repressed 86% of male-biased genes and induced ...

Tópico(s): Liver Disease Diagnosis and Treatment

2017 - Taylor & Francis | Molecular and Cellular Biology

Artigo Acesso aberto Revisado por pares

Ahmed Khalil, Mikhail Parker, Richard Mpanga, Şebnem Eren Çevik, Cassandra Thorburn, Alexander Suvorov,

Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives in a wide range of polymers. The generations born when environmental concentrations of PBDEs reached their maximum account in the United States for one-fifth of the total population. We hypothesized that exposure to PBDEs during sensitive developmental windows might result in long-lasting changes in liver metabolism. The present study was based on experiments with CD-1 mice and human hepatocellular carcinoma cells (human ...

Tópico(s): Carcinogens and Genotoxicity Assessment

2017 - Endocrine Society | Journal of the Endocrine Society

Artigo Revisado por pares

Ahmed Khalil, Mikhail Parker, Sarah E. Brown, Şebnem Eren Çevik, Lian W. Guo, Jake Jensen, Alexandra Olmsted, Daneal Portman, Haotian Wu, Alexander Suvorov,

Since 1965, polybrominated diphenyl ethers (PBDEs) have been used internationally as flame-retardant additives. PBDEs were recently withdrawn from commerce in North America and Europe due to their environmental persistence, bioaccumulative properties and endocrine-disrupting effects. Generations exposed perinatally to the highest environmental doses of PBDE account for one-fifth of the total United States population. While, toxicity of PBDE for the male reproductive system has been demonstrated in ...

Tópico(s): Air Quality and Health Impacts

2017 - Elsevier BV | Toxicology

Artigo Acesso aberto Revisado por pares

Haotian Wu, Molly Estill, Alexander Shershebnev, Alexander Suvorov, Stephen A. Krawetz, Brian W. Whitcomb, H. Dinnie, Tayyab Rahil, Cynthia K. Sites, J. Richard Pilsner,

Are preconception phthalate and phthalate replacements associated with sperm differentially methylated regions (DMRs) among men undergoing IVF?Ten phthalate metabolites were associated with 131 sperm DMRs that were enriched in genes related to growth and development, cell movement and cytoskeleton structure.Several phthalate compounds and their metabolites are known endocrine disrupting compounds and are pervasive environmental contaminants. Rodent studies report that prenatal phthalate exposures ...

Tópico(s): Effects and risks of endocrine disrupting chemicals

2017 - Oxford University Press | Human Reproduction

Artigo Acesso aberto

Corinne E. Hill, Sarah A. Sapouckey, Alexander Suvorov, Laura N. Vandenberg,

Developmental exposures to bisphenol A (BPA), an estrogen receptor agonist, can disrupt development of the female reproductive tract in rodents and non-human primates. Due to an increased public knowledge of negative health effects associated with BPA exposure, BPA has begun to be phased out of many consumer products and in some cases it has been replaced with structurally similar compounds including bisphenol S (BPS). This study examined CD-1 mice exposed to a low dose of BPS during early development ( ...

Tópico(s): Effects and risks of endocrine disrupting chemicals

2017 - Informa | Cogent Medicine

Revisão Acesso aberto Revisado por pares

J. Richard Pilsner, Mikhail Parker, Oleg Sergeyev, Alexander Suvorov,

Dioxins are a group of highly persistent chemicals that are generated as by-products of industrial and natural processes. Reduction in sperm counts is among the most sensitive endpoints of dioxin toxicity. The exact mechanism by which dioxins reduce sperm counts is not known. Recent data implicate the role of epididymal factors rather than disruption of spermatogenesis. Studies reviewed here demonstrate that dioxins induce the transfer of environmental conditions to the next generation via male ...

Tópico(s): Carcinogens and Genotoxicity Assessment

2017 - Elsevier BV | Reproductive Toxicology

Artigo Revisado por pares

Alexander Suvorov, Alex Shershebnev, Haotian Wu, Yulia A. Medvedeva, Oleg Sergeyev, J. Richard Pilsner,

Polybrominated diphenyl ethers (PBDEs) are a group of ubiquitous reproductive toxins. Given that spermatogenesis requires extensive epigenetic changes, we hypothesize that PBDEs impact sperm DNA methylation. Pregnant Wistar rats were exposed perinatally to 0.2 mg/kg 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and caudal epididymal sperm were collected from offspring on postnatal days (PNDs) 65 and 120. Libraries were prepared from sperm DNA and sequenced with an average of 18.0 million unique reads ...

Tópico(s): Epigenetics and DNA Methylation

2017 - Elsevier BV | Reproductive Toxicology