Srikumar Sen, Boxing Correspondent, Victoria McKee, Frances Gibb, Legal Affairs Correspondent, Bel Mooney, Nicholas Wood, Political Correspondent, Simon Barnes, Nicholas Davie Thornhill, Stephen Leather, Neil Bennett, Louis Heren, David Moss, Angela MacKay, Brian Wenham, Philip Howard, Tom Giles, David Hart, Ian Murray, Jeremy Kingston, Michael Binyon, James Bone, Clive Davis, Richard Evans, Media Editor, Carol Leonard, Kevin Eason, Motoring Correspondent, Stuart Jones Football Correspondent, Simon Wilde, Michael McCarthy, Stewart Tendler, Crime Correspondent, Alex Sutherland, Roddy Forsyth, Colin Narbrough Economics Correspondent, Martin Fletcher and Christopher Walker, J. Sykes, Martin Fletcher, Henry Gee, Mitchell Platts, Sam Kiley Higher Education Reporter, Mitchell Platts, Golf Correspondent, Peter Davenport, Nicholas Wood Political Correspondent, Alan Lorimer, Raymond Keene Chess Correspondent, Griff Rhys Jones, Louise Taylor, Peter Waymark, Michael Evans, Defence Correspondent, Ray Kennedy, Robin Young, Alan Hamilton, Ernest Beck, Thomson Prentice, Science Correspondent, Philip Robinson, John Young, Bob Smyth, Marion Devine, Rex Bellamy, David Hands, Charles Bremner, John Percival, Conor Cruise O'Brien, Quentin Cowdry Home Affairs Correspondent, Harvey Elliott, Air Correspondent, Oscar Moore, John Woodcock, Harry Debelius, P. Sotheran (Director), David Miller, H. P. Ruglys, Mitchell Platts Golf Correspondent, Philip Webster, Chief Political Correspondent, Nicolas Soames, Alan Toogood, Horticulture Correspondent, James Douglas, Director-General, Andrew McEwen, Diplomatic Editor, Robin Oakley, Political Editor, Kerry Gill, Peter Davalle, Raymond Keene, Chess Correspondent, Craig Brown, Peter Stothard, Paul Griffiths, Steve Acteson, Richard Marsh, Robert Rodwell, Sheila Oakes, Chairman, Roy Dean, Peter Dear and Gillian Maxey, David Young, Energy Correspondent, Barry Pickthall, Peter Guilford, Irving Wardle, Roger Boyes, Ian Ross, Sheila Gunn Political Reporter, Richard Bassett, Simon Tait, Arts Correspondent, David Hands Rugby Correspondent, Michael Dynes, Transport Correspondent, David Brewerton, Alastair Morton, Christopher Thomas, Jack Crossley, David Young, John Goodbody, Basil Woods, Clive White, Matthew Parris, Sarah Jane Checkland Art Market Correspondent, Jo Vale, Andrew Lycett, David Sinclair, John Lewis, Melinda Wittstock, George Chesterton, Simon Gourlay, President, Frances Gibb Legal Affairs Correspondent, Noël Goodwin, Christopher Warman, Rippon of Hexham, R. A. Hood, David Powell, Frances Gibb, William Barrett, Richard Evans and Tim Jones, Lee Rodwell, Colin Campbell, Tim Jones, Employment Affairs Correspondent, Philip Jacobson, Colin McQuillan, Vivien Goldsmith, Family Money Editor, Peggy Pyke-Lees, Michael Hornsby Agriculture Correspondent,
... fights rates freeze Shorts buys former Learfan plant Kluge named richest American Bm digging in for growth ...
1989 - Gale Group | TDA
... AND THE PELGER-HÜET ANOMALY W. KLUGE, W. KLUGE Alexandra Institution, Maitland, Union of South AfricaSearch for more papers by this author W. KLUGE, W. KLUGE Alexandra Institution, Maitland, Union of South AfricaSearch for more ...
Tópico(s): Historical Linguistics and Language Studies
1959 - Wiley | Journal of Intellectual Disability Research
Victoria McKee, Colin Fenge, Kenneth McLeish, Mike Graham, Paul Nelson, Richard Ellis, Helen FIELDING's, Mary Dowey, John Davison, Helen Davidson, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Bemard Cafferty, Eric Dymock, Susan d'Arcy, Matthew Bowman, Artyom Zaitsev Vilnius, Graham Rose, Nicolette Jones, Steward Else, Steve Clarke, Fidel Castro, Adam Nicolson, Julian Symons, Frederic Raphael, John Rowland, Mark Hosenball, Carol Sarler, Tom Bullimore, Marlna Valzey, Geordie Greig, Patrick Stoddart, Robert Sandall, Iain Johnstone, B Quirk, Donald Woods, Irwin Stelzer, Jeremy Isaacs General Director, John Newell, Franco Moschino, Ivan Fallon, Deryk Brown, Philip Ridley, Charles Wintour, David Dougill, Geordie Greig Arts Correspondent, Brian Moynahan Bonn, Jane Bird, J M Johnson, Sanjeeva Fernando, Tim Madge, John Swain, Joanna Goldsworthy, Hugh Canning, Margarette Driscoll, Jane Bird Technology Editor, Eric Detzer, Susan Crosland, Peter Kemp, Geoff Whitten, Robert Harris, Caroline Lees, Richard Palmer Environment Correspondent, John McVicar, George Perry, John Cassidy, Sue Mott, Robin Marlar, David Collins, Anita Brookner, Barry Burnett, Michael Jones Political Editor Dublin, Albert Armstrong, Carole Bettsworth, Tom Hervey, Jon Freeman, Judy Meweezen, Stuart Wavell, Paul Donovan, Chris Butlin, Janette Marshall, Nigella Lawson, B Riddleston Regional Opencast Director, Peter Lewis, Jeff Randall, Dr Peter Wilkins, Paul Driver, Elaine Cobbe, Frances Duffy, Hugh David, Austin MacCurtain, Peter Freedman, Jennie Hawthorne, Gillian Fairchild, Vera Rich, Rufus Olins, Stuart Weir Editor, Michael Durham, Tavleen Singh, David Lawrenson, John Hopkins, Martin Jacques, Brian Walden, Roger Williams, Desmon Shawe-Taylor, Gareth David, Brian Reading, Jim Wilson, Caspar Weinberger, Kate Saunders, Malcolm Winton, Anthony Isaacs, Richard Cook, Marie Colvin, Dr John Durant, Diana Wright, Craig Brown, S Punter, Andrew Lorenz Industrial Editor, Ian Anderson, Stephen Jones, Stephen Thorpe, Patrick Stodart, Rosemary Conley, Andrew Grice, Digby Anderson, Martin Searby, Ian Birrell, P G White, Peter Plani, Nigel Bowden Marbella, Chris Jones, Tim Willis, Andrew Hogg, Tony Rocca, Chris Stephen Bucharest, Norman Stone, Clive Everton, Richard Woods, Peter Johnson, Frances Rafferty, Shirley Harrison, Marion Hume, Maurice Chittenden, John Walsh, Ian Dunning, Iola Smith, David Hughes Chief Political Correspondent, Amin Rajan, Aileen Ballantyne Medical Correspondent, Brian MacArthur, Rebecca Fowler, Michael Jones Political Editor, Andrew Yates, James Blitz, Susan Raven, D J Taylor, Mike Smith, Elisabeth Rosenthal, Mihir Bose, Michael Smith, A Zenined, Susannah Herbert, Godfrey Smith, Paul Barker, Brian Glanville, Stan Levenson, John Carey, John Hill, Chris Dighton, J Ashmead, Norman Macrae, Tom Tickell, Gareth David Deputy City Editor, Lenny Henry, Judith Summers, Peter Dragadze, Liam Clarke, Colin Greenland, Pleasaunce Perry, Dr Glynis Breakwell, Jon Swain Panmunjom, Chris Lightbown, Jeff Randall City Editor, Hugh Pearman, Marina Vaizey, Richard Caseby, Margaret Park, Angela Long, Deborah Sacks, Frank Field, Penny Perrick, Tony Hetherington, G Easton Havant, Peter Roebuck, Richard Nixon, Walter Ellis, Joanna Simon, Iain Jenkins, Guy Williams, Boris Schapiro, Mark Wallington,
... rise and steady social fall of Mrs Patricia Kluge The Bin Club Steepleprint Ltd Hitachi Londoners with ...
1990 - Gale Group | Sunday Times HA GDA
Lazaros Papadopoulos, Panagiotis Α. Klonos, Marcel Kluge, Alexandra Zamboulis, Zoi Terzopoulou, Dimitra Kourtidou, Andreas Magaziotis, K. Chrissafis, Apostolos Kyritsis, Dimitrios Ν. Bikiaris, Tobias Robert,
In this work, novel polyester amides (PEAs) based on renewable poly(propylene furanoate) (PPF) were prepared via traditional melt polycondensation utilizing a preformed symmetric amido diol (AD) containing two internal amide bonds.
Tópico(s): Carbon dioxide utilization in catalysis
2021 - Royal Society of Chemistry | Polymer Chemistry
Srikumar Sen, Boxing Correspondent, David Wade, Frances Gibb, Legal Affairs Correspondent, Chris Wormell, Peter Gillman, Richard Thomson Banking Correspondent, Denis Pirrie, Michael Clark and Carol Leonard, Gordon Allan, Michael Stevenson, Philip Howard, Hilary Finch, R C Dixon, Michael Binyon, Jeremy Kingston, Clive Davis, Carol Leonard, Sarah Jane Checkland, Art Market Correspondent, Stuart Jones Football Correspondent, John Clare, Education Correspondent, Jenny Knight, Michael McCarthy, Colin Narbrough, F. R. Hartley, Principal, Gerald Davies, Bryan Stiles, Simon Walsh, Ahmed Fazl, Judith Banister, John Spicer, Lawrence Lever, Lloyd of Kilgerran, John Woodcock Cricket Correspondent, Thomson Prentice Science Correspondent, Peter Waymark, Michael Evans, Defence Correspondent, Ray Kennedy, Martin Fletcher, Political Reporter, John Young, Ronald Faux, Employment Affairs Correspondent, David Hands, Charles Bremner, Michael Hamlyn, South Asia Correspondent, Geoffrey Phillips, Anthony J. Byrne, Martin Fletcher Political Reporter, Simon Tait, Harvey Elliott, Air Correspondent, Geoffrey Alderman, Andrew Hislop, George Rae, Gavin Bell, Paul Vallely, Sydney Friskin, Nicholas Harling, Dennis Signy, Chris Thau, David Miller, John Higgins, T. E. Utley, Tom Batho, Edward Townsend and Nicholas Wood, Kerry Gill, Gareth Huw Davies, Peter Davalle, Arnold E. Bender, Giles Keating, R. H. B. Malim, Roland Radd, Steve Acteson, Peter Bryan, John Cooney, Alexandra Jackson, Richard Owen, Richard Carr, President, T. Mallinson, Vice President, Martin Searby, Maxwell Newton, Ian Ross, Ivor Davis, Peter Dixon, Richard Bassett, Keith MacKlin, Edward Townsend Industrial Correspondent, David Hands Rugby Correspondent, Christopher Thomas, John Goodbody, Christopher Walker, Daniel Ward Motor Industry Correspondent, Clive White, Frank Allaun, Michael Seely, Peter Dear and Peter Davalle, Barry Wood, Julia Reilly, John Woodcock, Cricket Correspondent, Jill Sherman, Robert Matthews and Nicholas Wood, Michael Dynes Ankara, John Young Agriculture Correspondent, Rodney Lord, Economics Editor, David Powell, Sam Kiley, Nicholas Soames, Vince Wright, Lee Rodwell, Harvey Elliott Air Correspondent, Penny Perrick, John Goodbody, Sports News Correspondent, Jan Raath, Philip Jacobson, Alan Tomlinson, Port-au-Prince, Colin McQuillan, Rodney Lord Economics Editor, Peter Evans, Home Affairs Correspondent, Richard Wigg,
... Record More rues for Crowe in second innings Kluge prevails on borrowed bike Cyclo-Cross Cram's ...
1987 - Gale Group | TDA
Edward T.J. Rochford, Marina Sabaté Brescó, Stephan Zeiter, Katharina Kluge, Alexandra H.C. Poulsson, Mario Ziegler, R. Geoff Richards, Liam OʼMahony, T. Fintan Moriarty,
Post-traumatic bone fractures are commonly fixed with implanted devices to restore the anatomical position of bone fragments and aid in the healing process. Bacterial infection in this situation is a challenge for clinicians due to the need for aggressive antibiotic therapy, debridement of infected tissues, and the need to maintain fracture stability. The aim of this study was to monitor immune responses that occur during healing and during Staphylococcus aureus infection, in a clinically relevant ...
Tópico(s): Antimicrobial Peptides and Activities
2015 - Elsevier BV | Bone
T. Kluge, Stefan Liehr, Alexandra Lux, Petra Moser, Steffen Niemann, Nicole Umlauf, Wilhelm Urban,
This paper presents main findings of a feasibility study for a joint transdisciplinary project to strengthen the implementation of integrated water resources management (IWRM) in the Cuvelai Basin, northern Namibia. The region is characterised by seasonal alterations of droughts and heavy rainfall, mostly saline groundwater and a lack of permanent rivers. Difficult local conditions pose a great challenge for water supply against the background of high population density. Currently, most drinking ...
Tópico(s): Water resources management and optimization
2007 - Elsevier BV | Physics and Chemistry of the Earth Parts A/B/C
Anna Wessels, Holger Kluge, Frank Hirche, Andreas Kiowski, Alexandra Schutkowski, E. Corrent, Jörg Bartelt, Bettina König, Gabriele I. Stangl,
In addition to its role as an essential protein component, leucine (Leu) displays several other metabolic functions such as activation of protein synthesis. This property makes it an interesting amino acid for the therapy of human muscle atrophy and for livestock production. However, Leu can stimulate its own degradation via the branched-chain keto acid dehydrogenase complex (BCKDH). To examine the response of several tissues to excessive Leu, pigs were fed diets containing two- (L2) and four-fold ( ...
Tópico(s): Metabolism and Genetic Disorders
2016 - Public Library of Science | PLoS ONE
Julia Kühn, Alexandra Schutkowski, Holger Kluge, Frank Hirche, Gabriele I. Stangl,
Food-based strategies need to be developed to improve the vitamin D status of individuals. Recent studies identified ultraviolet B irradiation as an efficient method to enrich mushrooms and eggs with vitamin D. The aim of this study was to determine whether free-range farming of hens could provide a valuable method to produce vitamin D-enriched eggs.Laying hens were randomly assigned to three groups of 33 to 34 animals each, and were kept either indoors (indoor group), outdoors (outdoor group), or ...
Tópico(s): Insect Utilization and Effects
2013 - Elsevier BV | Nutrition
Bodo Hoffmeister, Gabriele Peyerl‐Hoffmann, Sven Pischke, Ines Zollner‐Schwetz, Robert Krause, Matthias C. Müller, Alexandra Gráf, Stefan Kluge, Gerd Burchard, Winfried V. Kern, Norbert Suttorp, Jakob P. Cramer,
Leptospirosis, a zoonosis occurring worldwide, has a broad spectrum of clinical manifestations. Recently, various countries observed an increase of severe anicteric cases. In Austria and Germany, growing numbers of imported cases are notified in addition to autochthonous infections. The aim of this study was to assess whether imported and autochthonous cases differ in clinical manifestations and outcome. We retrospectively analyzed 24 imported and 35 autochthonous cases treated in six infectious ...
Tópico(s): Leptospirosis research and findings
2010 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Marcel Kluge, Lazaros Papadopoulos, Andreas Magaziotis, Dimitrios Tzetzis, Alexandra Zamboulis, Dimitrios Ν. Bikiaris, Tobias Robert,
The synthesis of polyamides and poly(ester amide)s derived from 2,5-furandicarboxylic acid frequently leads to amorphous polymeric materials. Formation of intramolecular hydrogen bonds between the oxygen heteroatom in the furan ring and hydrogens of the amide bonds reduces the intermolecular hydrogen bonds that are usually responsible for the high thermal and mechanical performance of these materials. To circumvent this problem, aliphatic–aromatic poly(ester amide)s were synthesized in this study ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2020 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Teresa Tsai, Sabrina Reinehr, Leonie Deppe, Alexandra Strubbe, Nils Kluge, H. Burkhard Dick, Stephanie C. Joachim,
Glaucoma is a complex and multifactorial disease defined as the loss of retinal ganglion cells (RGCs) and their axons. Besides an elevated intraocular pressure (IOP), other mechanisms play a pivotal role in glaucoma onset and progression. For example, it is known that excitotoxicity, immunological alterations, ischemia, and oxidative stress contribute to the neurodegeneration in glaucoma disease. To study these effects and to discover novel therapeutic approaches, appropriate animal models are needed. ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2024 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Elmo Neuberger, Alexandra Brahmer, Tobias Ehlert, Katrin Kluge, Keito F A Philippi, Simone Cosima Boedecker-Lips, Julia Weinmann‐Menke, Perikles Simon,
Abstract Circulating cell-free DNA (cfDNA) has been investigated as a screening tool for many diseases. To avoid expensive and time-consuming DNA isolation, direct quantification PCR assays can be established. However, rigorous validation is required to provide reliable data in the clinical and non-clinical context. Considering the International Organization for Standardization, as well as bioanalytical method validation guidelines, we provide a comprehensive procedure to validate assays for cfDNA ...
Tópico(s): Lymphoma Diagnosis and Treatment
2021 - Nature Portfolio | Scientific Reports
Pierre‐François Laterre, Peter Pickkers, Gernot Marx, Xavier Wittebole, Ferhat Meziani, Thierry Dugernier, Vincent Huberlant, Tobias Schuerholz, Bruno François, Jean-Baptiste Lascarrou, Albertus Beishuizen, Haikel Oueslati, Damien Contou, Oscar Hoiting, Jean-Claude Lachérade, Benjamin G. Chousterman, Julien Pottecher, Michael Bauer, Thomas Godet, Mahir Karakas, Julie Helms, Andreas Bergmann, Jens Zimmermann, Kathleen M. Richter, Oliver Hartmann, Melanie Pars, Alexandre Mebazaa, Diego Castanares‐Zapatero, Christine Collienne, Ludovic Gèrards, Phillipe Hantson, Virginie Montiel, Caroline Berghe, M Dujardin, Leslie Gielens, Suzanne Renard, Philippe G. Jorens, Pierre Asfar, Gaëtan Plantefève, Jacques Duranteau, Emmanuel Weiss, Constance Vuillard, Anne-Laure Fedou, Marine Goudelin, Bruno Evrard, Thomas Daix, Arnaud Desachy, Philippe Vignon, Anne-Aurore Duchambon, Ludmila Baudrillart, P Bourzeix, Alexandra Gay, Céline Prevost, Coralie Chalot, Isabelle Herafa, P. Engels, Martin Maëlle, Lila-Fariza Abeud, Laure Berton, Kamilė Čerlinskaitė‐Bajorė, Nicolas Deye, Marie-Céline Fournier, Tassadit Hadjam, Alexa Hollinger, Tuija Javanainen, Clément Jourdaine, Matthieu Legrand, Badr Louadah, Arthur Neuschwander, Raphaël Clère-Jehl, Julien Demiselle, Hamid Merdji, Alexandra Monnier, Emmanuelle Mercier, Stefan Kluge, Alexander Zarbock, Arthur R. H. van Zanten, Wytze Vermeijden, Tom Dormans,
Investigate safety and tolerability of adrecizumab, a humanized monoclonal adrenomedullin antibody, in septic shock patients with high adrenomedullin. Phase-2a, double-blind, randomized, placebo-controlled biomarker-guided trial with a single infusion of adrecizumab (2 or 4 mg/kg b.w.) compared to placebo. Patients with adrenomedullin above 70 pg/mL, < 12 h of vasopressor start for septic shock were eligible. Randomization was 1:1:2. Primary safety (90-day mortality, treatment emergent adverse events ( ...
Tópico(s): Heart Failure Treatment and Management
2021 - Springer Science+Business Media | Intensive Care Medicine
Juliane Radtke, Stefanie Geißler, Alexandra Schutkowski, Corinna Brandsch, Holger Kluge, Marcello Duranti, Sylvia Keller, Gerhard Jahreis, Frank Hirche, Gabriele I. Stangl,
Lupin proteins exert hypocholesterolemic effects in man and animals, although the underlying mechanism remains uncertain. Herein we investigated whether lupin proteins compared to casein modulate sterol excretion and mRNA expression of intestinal sterol transporters by use of pigs as an animal model with similar lipid metabolism as humans, and cellular cholesterol-uptake by Caco-2 cells.Two groups of pigs were fed cholesterol-containing diets with either 230 g/kg of lupin protein isolate from L. ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2014 - BioMed Central | Nutrition & Metabolism
Alexandra Schutkowski, Julia Krämer, Holger Kluge, Frank Hirche, Andreas Krombholz, Torsten Theumer, Gabriele I. Stangl,
Vitamin D deficiency is a global health problem. This study aimed to investigate the efficacy of ultraviolet (UV) B radiation for improving vitamin D3 content of eggs and meat. In a two-factorial design hens that received diets with 0 (-D3) or 3,000 IU (+D3) vitamin D3/kg were non-exposed (-UVB) or exposed to UVB radiation (+UVB) for 3 h daily over 4 weeks. Data show that UVB radiation was very effective in raising the vitamin D3 content of egg yolk and meat. Egg yolk from +UVB/−D3 hens had a higher vitamin ...
Tópico(s): Consumer Attitudes and Food Labeling
2013 - Public Library of Science | PLoS ONE
Goda Kalinauskaitė, Carolin Senger, Anne Kluge, Christian Furth, Markus Kufeld, Ingeborg Tinhofer, Volker Budach, Marcus Beck, Alexandra Hochreiter, Arne Grün, Carmen Stromberger,
Androgen deprivation therapy (ADT) remains the standard therapy for patients with oligometastatic prostate cancer (OMPC). Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT)-based stereotactic body radiotherapy (SBRT) is emerging as an alternative option to postpone starting ADT and its associated side effects including the development of drug resistance. The aim of this study was to determine progression free-survival (PFS) and treatment failure free-survival ( ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2020 - Public Library of Science | PLoS ONE
Nicole Matschiavelli, Sindy Kluge, Carolin Podlech, Daniel Standhaft, Georg Grathoff, Atsushi Ikeda‐Ohno, Laurence N. Warr, Alexandra Chukharkina, Thuro Arnold, Andrea Cherkouk,
In the multibarrier concept for the deep geological disposal of high-level radioactive waste (HLW), bentonite is proposed as a potential barrier and buffer material for sealing the space between the steel canister containing the HLW and the surrounding host rock. In order to broaden the spectra of appropriate bentonites, we investigated the metabolic activity and diversity of naturally occurring microorganisms as well as their time-dependent evolution within the industrial B25 Bavarian bentonite ...
Tópico(s): CO2 Sequestration and Geologic Interactions
2019 - American Chemical Society | Environmental Science & Technology
Angela Hommel, Deike Hesse, Wolfgang Völker, Alexander Jaschke, Markus Moser, Thomas Engel, Matthias Blüher, Claudia Zahn, Alexandra Chadt, Karen Ruschke, Heike Vogel, Reinhart Kluge, Horst Robenek, Hans‐Georg Joost, Annette Schürmann,
ADP-ribosylation factor (ARF)-related protein 1 (ARFRP1) is a GTPase regulating protein trafficking between intracellular organelles.Here we show that mice lacking Arfrp1 in adipocytes (Arfrp1 ad؊/؊ ) are lipodystrophic due to a defective lipid droplet formation in adipose cells.Ratios of mono-, di-, and triacylglycerol, as well as the fatty acid composition of triglycerides, were unaltered.Lipid droplets of brown adipocytes of Arfrp1 ad؊/؊ mice were considerably smaller and exhibited ultrastructural ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2009 - Taylor & Francis | Molecular and Cellular Biology
Heike Vogel, Dirk Montag, Timo Kanzleiter, Wenke Jonas, Daniela Matzke, Stephan Scherneck, Alexandra Chadt, Jonas Töle, Reinhart Kluge, Hans‐Georg Joost, Annette Schürmann,
A region on mouse distal chromosome 1 (Chr. 1) that is highly enriched in quantitative trait loci (QTLs) controlling neural and behavioral phenotypes overlaps with the peak region of a major obesity QTL (Nob3.38), which we identified in an intercross of New Zealand Obese (NZO) mice with C57BL/6J (B6). By positional cloning we recently identified a microdeletion within this locus causing the disruption of Ifi202b that protects from adiposity by suppressing expression of 11β-Hsd1. Here we show that the ...
Tópico(s): Genetic and phenotypic traits in livestock
2013 - Public Library of Science | PLoS ONE
Alexandra Trinks, Miha Milek, Dieter Beule, Julie Kluge, Stefan Florian, Christine Sers, David Horst, Markus Morkel, Philip Bischoff,
Single-cell transcriptional profiling reveals cell heterogeneity and clinically relevant traits in intra-operatively collected patient-derived tissue. So far, single-cell studies have been constrained by the requirement for prospectively collected fresh or cryopreserved tissue. This limitation might be overcome by recent technical developments enabling single-cell analysis of FFPE tissue.
Tópico(s): RNA modifications and cancer
2024 - Springer Nature | Cellular Oncology
Antoine Flahault, Alexandra Calmy, Dominique Costagliola, Oxana M. Drapkina, Isabella Eckerle, Heidi J. Larson, Helena Legido‐Quigley, Catherine J. Noakes, Michel D. Kazatchkine, Hans Kluge,
While the world is transitioning out of the emergency phase of the COVID-19 pandemic,1WHOStatement on the fifteenth meeting of the IHR (2005) Emergency Committee on the COVID-19 pandemic.https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemicDate: May 5, 2023Date accessed: May 14, 2023Google Scholar new surges of COVID-19 continue to occur across Europe because ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2023 - Elsevier BV | The Lancet
Edward T.J. Rochford, Marina Sabaté Brescó, Alexandra H.C. Poulsson, Katharina Kluge, Stephan Zeiter, Mario Ziegler, Liam OʼMahony, R. Geoff Richards, T. Fintan Moriarty,
Abstract The development of an infection is a major complication for some patients with implanted biomaterials. Whether the material or surface composition of the used biomaterial influences infection has not been directly compared for key biomaterials currently in use in human patients. We conducted a thorough in vitro and in vivo investigation using titanium (Ti) and polyether–ether–ketone (PEEK) as both commercially available and as modified equivalents (surface polished Ti, and oxygen plasma treated ...
Tópico(s): Bone Tissue Engineering Materials
2018 - Wiley | Journal of Biomedical Materials Research Part B Applied Biomaterials
Alexandra Schutkowski, Bettina König, Holger Kluge, Frank Hirche, Andrea Henze, Tanja Schwerdtle, Stefan Lorkowski, Christine Dawczynski, Alexander Gabel, Ivo Große, Gabriele I. Stangl,
Epidemiological studies revealed that dietary proteins can contribute to the modulation of the cardiovascular disease risk. Still, direct effects of dietary proteins on serum metabolites and other health-modulating factors have not been fully explored. Here, we compared the effects of dietary lupin protein with the effects of beef protein and casein on the serum metabolite profile, cardiovascular risk markers and the fecal microbiome. Pigs were fed diets containing 15% of the respective proteins ...
Tópico(s): Meat and Animal Product Quality
2019 - Elsevier BV | The Journal of Nutritional Biochemistry
Alister Browne, Grant Gillett, Martin Tweeddale,
... 3 p. 248-253 Elective Ventilation Reply to Kluge Alister Browne, Alister Browne Division of Health Care Ethics,Search for more papers by this authorGrant Gillett, Grant Gillett Bioethics Research Centre, University of Otago; Health Care Otago,Search for more papers by this authorMartin Tweeddale, Martin Tweeddale Department of Intensive Care Medicine, Queen Alexandra Hospital, PortsmouthSearch for more papers by this author ...
Tópico(s): Ethics in medical practice
2000 - Wiley | Bioethics
Unlängst hat der Umweltrat eine Lanze gebrochen für die Liberalisierung und Deregulierung der deutschen Wasserwirtschaft. Angesichts der ökologischen Bedeutung des Wasserbereichs ist jedoch zunächst ein Moratorium notwendig, um die zahlreichen ungelösten Probleme zu klären.
2000 - oekom verlag | Ökologisches Wirtschaften - Fachzeitschrift
Alexandra Schutkowski, Holger Kluge, Paula Trotz, Gerd Hause, Bettina König, Monika Wensch-Dorendorf, Gabriele I. Stangl,
Tópico(s): Birth, Development, and Health
2018 - Springer Science+Business Media | European Journal of Nutrition
Alexandra Chadt, Katja Leicht, Atul S. Deshmukh, Lake Q. Jiang, Stephan Scherneck, Ulrike Bernhardt, Tanja Dreja, Heike Vogel, Katja Schmolz, Reinhart Kluge, Juleen R. Zierath, Claus Hultschig, Rob C. Hoeben, Annette Schürmann, Hans‐Georg Joost, Hadi Al‐Hasani,
Tópico(s): Ubiquitin and proteasome pathways
2008 - Nature Portfolio | Nature Genetics
Susanne Singer, Judith Keszte, Andreas Dietz, Angela Kluge, S. Plontke, Marc Heim, Hans J. Vogel, C. Matthäus, Jens Oeken, Kerstin Breitenstein, Sven Koscielny, Friedemann Pabst, J. Schock, T. Eichhorn, E. Meister, Anja Mehnert, Alexandra Meyer,
Ziel dieser Studie war es herauszufinden, wie viele Patienten nach einer Laryngektomie (LE) erfolgreich ins Berufsleben zurückkehren und welche Faktoren eine berufliche Wiedereingliederung unterstützen. Laryngektomierte (n=231) im Alter von bis zu 60 Jahren wurden vor der LE (t1), vor der Anschlussheilbehandlung (AHB) (t2), am Ende der AHB (t3), 1 Jahr nach LE (t4), 2 Jahre nach LE (t5) und 3 Jahre nach LE (t6) mithilfe von strukturierten Interviews und Fragebögen befragt. Vor der LE waren n=76 (38%) der ...
Tópico(s): Voice and Speech Disorders
2013 - Thieme Medical Publishers (Germany) | Laryngo-Rhino-Otologie
Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei Bogdanov, Friederike Lämmer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh‐Behrens, Claus Zimmer, Alexandra S. Gersing,
Abstract After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and ...
Tópico(s): Barrier Structure and Function Studies
2018 - Nature Portfolio | Scientific Reports