Charlotte Charpentier, Alexandre Storto, Cathia Soulié, Valentine Marie Ferré, Marc Wirden, Véronique Joly, Sidonie Lambert-Niclot, Romain Palich, Laurence Morand‐Joubert, Roland Landman, Karine Lacombe, Christine Katlama, Jade Ghosn, Anne‐Geneviève Marcelin, Vincent Cálvez, Diane Descamps,
Abstract Background Multivariable baseline factor analysis across cabotegravir + rilpivirine clinical trials showed that HIV-1 subtypes A6/A1 and the presence of rilpivirine resistance-associated mutations (RAMs) were associated with an increased risk of virological failure of this dual therapy. The aim of this study was to describe the prevalence of genotypic baseline risk factors for cabotegravir + rilpivirine failure among ARV-naive patients. Patients and methods From 2010 to 2020, 4212 sequences ...
Tópico(s): HIV/AIDS Research and Interventions
2021 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Cathia Soulié, Maria Mercedes Santoro, Charlotte Charpentier, Alexandre Storto, Dimitrios Paraskevis, Domenico Di Carlo, William Gennari, Gaetana Sterrantino, Maurizio Zazzi, Carlo Federico Perno, Vincent Cálvez, Diane Descamps, Francesca Ceccherini‐Silberstein, Anne‐Geneviève Marcelin,
Doravirine is a novel HIV-1 NNRTI recently shown to be non-inferior to both darunavir/ritonavir and efavirenz in combination therapy with two NRTIs in treatment-naive patients. Doravirine has an in vitro resistance profile that is distinct from other NNRTIs and retains activity against viruses containing the most frequently transmitted NNRTI mutations.The aim of this study was to examine the prevalence of doravirine resistance-associated mutations in HIV-1-infected treatment-naive patients in Europe. ...
Tópico(s): HIV Research and Treatment
2018 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Bercelin Maniangou, Nolwenn Legrand, Mehdi Alizadeh, Ulysse Guyet, Catherine Willem, Gaëlle David, Éric Charpentier, Alexandre Walencik, Christelle Retière, Katia Gagne,
The impact of natural killer (NK) cell alloreactivity on hematopoietic stem cell transplantation (HSCT) outcome is still debated due to the complexity of graft parameters, HLA class I environment, the nature of killer cell immunoglobulin-like receptor (KIR)/KIR ligand genetic combinations studied, and KIR+ NK cell repertoire size. KIR genes are known to be polymorphic in terms of gene content, copy number variation, and number of alleles. These allelic polymorphisms may impact both the phenotype and ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2017 - Frontiers Media | Frontiers in Immunology
Emmanuel Charpentier, Alexandre Barna, Loı̈c Guillevin, Jean‐Michel Juliard,
Following the development of stents, then drug-eluting stents (DES), bioresorbable scaffolds are proposed as a third evolution in coronary angioplasty, aiming to reduce the incidence of restenosis and stent thrombosis and to restore vascular physiology. At least 16 such devices are currently under development, but published clinical data were available for only three of them in September 2014. The first device is Abbott's BVS®, a poly-L-lactic acid (PLLA)-based everolimus-eluting device, which has ...
Tópico(s): Cardiac Imaging and Diagnostics
2015 - Elsevier BV | Archives of cardiovascular diseases
Sidonie Lambert-Niclot, C. Charpentier, Alexandre Storto, Djeneba Fofana, C. Soulie, Slim Fourati, Benoît Visseaux, Marc Wirden, Laurence Morand‐Joubert, Bernard Masquelier, Philippe Flandre, Vincent Cálvez, Diane Descamps, Anne‐Geneviève Marcelin,
The prevalence of rilpivirine, emtricitabine and tenofovir resistance-associated mutations (RAMs), described in vitro and in vivo, was determined in antiretroviral-naive patients.From 2008 to 2011, 1729 treatment-naive patients were tested for resistance by bulk sequencing. We studied the primary rilpivirine RAMs (K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, H221Y, F227C and M230I/L) and other potential rilpivirine-associated mutations (V90I, L100I, K101T, E138S, V179D/I, Y188L, V189I, G190A/E/S and M230V). ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2013 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Sidonie Lambert-Niclot, C. Charpentier, Alexandre Storto, Djeneba Fofana, Cathia Soulié, Slim Fourati, Marc Wirden, Laurence Morand‐Joubert, Bernard Masquelier, Philippe Flandre, Vincent Cálvez, Diane Descamps, Anne‐Geneviève Marcelin,
In the context of simplification strategies, it is essential to know the feasibility of a switch to a rilpivirine-based therapy. The aim of this study was to describe rilpivirine, tenofovir and emtricitabine resistance in HIV-1-infected patients who experienced virological failure during their previous antiretroviral treatment. The studied population included two groups of patients, all rilpivirine naive, tested for resistance by bulk sequencing from 2008 to 2011: the first group (n = 998) failing ...
Tópico(s): Biochemical and Molecular Research
2013 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Xiaoju Ni, Olivier Delelis, Charlotte Charpentier, Alexandre Storto, Gilles Collin, Florence Damond, Diane Descamps, Jean‐François Mouscadet,
Abstract Background HIV-2 is endemic in West Africa and has spread throughout Europe. However, the alternatives for HIV-2-infected patients are more limited than for HIV-1. Raltegravir, an integrase inhibitor, is active against wild-type HIV-2, with a susceptibility to this drug similar to that of HIV-1, and is therefore a promising option for use in the treatment of HIV-2-infected patients. Recent studies have shown that HIV-2 resistance to raltegravir involves one of three resistance mutations, ...
Tópico(s): Biochemical and Molecular Research
2011 - BioMed Central | Retrovirology
Diane Descamps, Marie‐Laure Chaix, Brigitte Montès, Sophie Pakianather, C. Charpentier, Alexandre Storto, Francis Barin, Georges Dos Santos, Anne Krivine, Constance Delaugerre, Jacques Izopet, Anne‐Geneviève Marcelin, Anne Maillard, Laurence Morand‐Joubert, C. Pallier, Jean‐Christophe Plantier, Catherine Tamalet, Jacqueline Cottalorda, Delphine Desbois, Vincent Cálvez, Françoise Brun‐Vézinet, Bernard Masquelier, Dominique Costagliola, Chakib Alloui, Dominique Bettinger, Guerric Anies, Bernard Masquelier, Sophie Vallet, Cécile Henquell, Magali Bouvier‐Alias, G. DosSantos, Anne Signori-Schmück, Sylvie Ranger‐Rogez, Patrice André, J. C. Tardy, Mary‐Anne Trabaud, Catherine Tamalet, Brigitte Montès, Jacqueline Cottalorda, Diane Descamps, Françoise Brun‐Vézinet, Charlotte Charpentier, Marie‐Laure Chaix, Delphine Desbois, Slim Fourati, Anne‐Geneviève Marcelin, Vincent Cálvez, Philippe Flandre, Laurence Morand‐Joubert, Constance Delaugerre, Annick Ruffault, Anne Maillard, Jean‐Christophe Plantier, Thomas Bourlet, Hénia Saoudin, Jacques Izopet, Francis Barin,
To estimate the prevalence of transmitted drug resistance mutations and non-B subtype circulation in antiretroviral-naive chronically HIV-1-infected patients in France. Resistance mutations were sought in samples from 530 newly diagnosed HIV-1-infected patients from October 2006 to March 2007. Protease and reverse transcriptase mutations were identified from the 2007 Stanford Resistance Surveillance list. Reverse transcriptase and protease resistance mutations were determined in 466 patients with ...
Tópico(s): HIV/AIDS Research and Interventions
2010 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Lucile Larrouy, Corine Chazallon, Roland Landman, Catherine Capitant, Gilles Peytavin, Gilles Collin, Charlotte Charpentier, Alexandre Storto, Gilles Pialoux, Christine Katlama, Pierre‐Marie Girard, P. Yéni, J.-P. Aboulker, Françoise Brun‐Vézinet, Diane Descamps,
ABSTRACT ANRS 127 was a randomized pilot trial involving naïve patients receiving two dual-boosted protease inhibitor (PI) combinations. Virological response, defined as a plasma HIV RNA level of <50 copies/ml at week 16, occurred in only 41% patients. Low baseline plasma HIV RNA level was the only significant predictor of virological response. The purpose of this study was to investigate the impact on virological response of pretherapy mutations in cleavage sites of gag , gag-pol , and the gag-pol frameshift ...
Tópico(s): HIV/AIDS Research and Interventions
2010 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Ludovic Charpentier, Alexandre Maı̂tre, Marianne Balat‐Pichelin, Sylvie Foucaud, F. Audubert,
The influence of an alumina content (2 wt.%) on the oxidation behavior of hot-pressed α-SiC is studied. Sintering of α-SiC powder with alumina rests on the formation of a liquid phase corresponding to the eutectic composition in the SiO2–Al2O3 system. The oxidation kinetics of pure α-SiC at 1470 K under helium with an oxygen partial pressure of 0.1 Pa is linear, although silica is produced. The formation of Al-rich crystallized phase could be responsible for the slower oxidation kinetics of alumina- ...
Tópico(s): Advanced materials and composites
2008 - Elsevier BV | Scripta Materialia
A. Defois, Nina Bon, Alexandre Charpentier, Mélina Georget, Nicolas Gaigeard, Frédéric Blanchard, Antoine Hamel, D. Waast, Jean Armengaud, Ophélie Renoult, Claire Pecqueur, Yves Maugars, Marie‐Astrid Boutet, Jérôme Guicheux, Claire Vinatier,
Abstract Background Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an important role in osteoarthritis progression. In this context, pro-inflammatory cytokines are widely used to mimic the inflammatory component of osteoarthritis in vitro. However, the therapeutic failures of clinical trials evaluating anti-cytokines drugs highlight the lack of ...
Tópico(s): Chemokine receptors and signaling
2023 - BioMed Central | Cell Communication and Signaling
Alexandre Charpentier Poncelet, Christoph Helbig, Philippe Loubet, Antoine Beylot, Stephanie Müller, Jacques Villeneuve, Bertrand Laratte, Andrea Thorenz, Axel Tuma, Guido Sonnemann,
The consumption of most metals continues to rise following ever-increasing population growth, affluence and technological development. Sustainability considerations urge greater resource efficiency and retention of metals in the economy. We model the fate of a yearly cohort of 61 extracted metals over time and identify where losses are expected to occur through a life-cycle lens. We find that ferrous metals have the longest lifetimes, with 150 years on average, followed by precious, non-ferrous ...
Tópico(s): Environmental Impact and Sustainability
2022 - Nature Portfolio | Nature Sustainability
Alexandre Charpentier Poncelet, Philippe Loubet, Christoph Helbig, Antoine Beylot, Stephanie Müller, Jacques Villeneuve, Bertrand Laratte, Andrea Thorenz, Axel Tuma, Guido Sonnemann,
Abstract Purpose The accessibility to most metals is crucial to modern societies. In order to move towards more sustainable use of metals, it is relevant to reduce losses along their anthropogenic cycle. To this end, quantifying dissipative flows of mineral resources and assessing their impacts in life cycle assessment (LCA) has been a challenge brought up by various stakeholders in the LCA community. We address this challenge with the extension of previously developed impact assessment methods and ...
Tópico(s): Mining and Resource Management
2022 - Springer Science+Business Media | The International Journal of Life Cycle Assessment
Alexandre Charpentier Poncelet, Christoph Helbig, Philippe Loubet, Antoine Beylot, Stephanie Müller, Jacques Villeneuve, Bertrand Laratte, Andrea Thorenz, Axel Tuma, Guido Sonnemann,
The dissipation of metals leads to potential environmental impacts, usually evaluated for product systems with life cycle assessment. Dissipative flows of metals become inaccessible for future users, going against the common goal of a more circular economy. Therefore, they should be addressed in life cycle impact assessment (LCIA) in the area of protection "Natural Resources." However, life cycle inventory databases provide limited information on dissipation as they only track emissions to the environment ...
Tópico(s): Sustainable Supply Chain Management
2021 - Wiley | Journal of Industrial Ecology
Alexandre Charpentier Poncelet, Philippe Loubet, Bertrand Laratte, Stephanie Müller, Jacques Villeneuve, Guido Sonnemann,
A switch on-switch off (SOSO) approach to mining relies on an integrated modular and mobile plant. It is appropriate for rapid start-up and cessation of production from ore deposits that have economic viability dependent on fluctuating commodity prices. This study aims at assessing the environmental performance of the SOSO approach in a life cycle perspective, using evidence collected during its pilot-scale implementation on a high-grade lead deposit located in Bosnia-Herzegovina. The deployed modules ...
Tópico(s): Mining and Resource Management
2019 - Elsevier BV | Resources Conservation and Recycling
Alexandre Charpentier Poncelet, Antoine Beylot, Philippe Loubet, Bertrand Laratte, Stephanie Müller, Jacques Villeneuve, Guido Sonnemann,
Important advances have been made to define the multiple impact pathways relating mineral resource use to the area of protection (AoP) natural resources in life cycle assessment (LCA). Yet, the link between stakeholders’ interests and the aspects relevant to resource use as addressed by existing impact assessment methods has so far only marginally been explored. This article proposes to go beyond the case-specific determination of stakeholders’ interests (and the associated selection of impact assessment ...
Tópico(s): Environmental and Social Impact Assessments
2021 - Elsevier BV | Resources Conservation and Recycling
G Benoît, L Alexandre, M Moukarzel, Y. Yataghene, B Charpentier, A Jardin,
... date: 1-Mar-1997.Benoit G, Blanchet P, Alexandre L and Charpentier B (2018) Insertion of a Double Pigtail Ureteral ... G. Benoit More articles by this author L. Alexandre More articles by this author M. Moukarzel More articles by this author Y. Yataghene More articles by this author B. Charpentier More articles by this author A. Jardin More ...
Tópico(s): Pediatric Urology and Nephrology Studies
1993 - Lippincott Williams & Wilkins | The Journal of Urology
Elodie Nicoleau, Sophie Schuller, Frédéric Angeli, Thibault Charpentier, Patrick Jollivet, Alexandre Le Gac, Maxime Fournier, Adel Mesbah, Filipe Vasconcelos,
The effects of phase separation by nucleation and growth as well as those of crystallization on the structure and the chemical durability of sodium borosilicate glasses enriched in molybdenum oxide were investigated. Increasing concentrations of MoO3 (0 to 10% molar) were added to glasses which were homogeneous (MoO3 ≤ 1.4% molar) or with crystallizations and separated phases (MoO3 > 1.4% molar). Their structure was determined by 11B, 23Na, 29Si and 95Mo MAS NMR, and 23Na MQMAS NMR, coupled with DFT calculations ...
Tópico(s): Advanced Condensed Matter Physics
2015 - Elsevier BV | Journal of Non-Crystalline Solids
Benoît Visseaux, Margarita Hurtado‐Nedelec, C. Charpentier, Gilles Collin, Alexandre Storto, Sophie Matheron, Lucile Larrouy, Florence Damond, Françoise Brun‐Vézinet, Diane Descamps,
Objective. The use of CCR5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (HIV-2) tropism, as established in HIV-1. The aim of our study was to identify genotypic determinants of HIV-2 tropism located in the gp105 V3 loop. Methods. HIV-2 tropism phenotypic assays were performed on 53 HIV-2 clinical isolates using GFP expressing human osteosarcoma T4 [GHOST(3)] cell lines expressing CD4 and CCR5 or CXCR4 coreceptors. The gp105 V3 loop was sequenced and analyzed. Results. ...
Tópico(s): Immune Cell Function and Interaction
2011 - Oxford University Press | The Journal of Infectious Diseases
Pascal Barbin, Jean-Luc Cheval, Jean-François Gilis, Pierre Strehaiano, Patricia Taillandier,
... 387– 392. 20 Guilloux-Benatier, M., Chassage, D., Alexandre, H., Charpentier, C. and Feuillat, M., Influence de l'autolyse ...
Tópico(s): Horticultural and Viticultural Research
2008 - Wiley | Journal of the Institute of Brewing
Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Li Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Bélisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, G. Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, Stephen Eyre, Constantin Polychronakos, Philippe Froguel,
Tópico(s): Genetics and Neurodevelopmental Disorders
2007 - Nature Portfolio | Nature
Stephen F. Lieberman, Frederick S. Keller, John M. Barry, Josef Rösch,
... and Research, Inc.FiguresReferencesRelatedDetailsCited ByBenoit G, Blanchet P, Alexandre L and Charpentier B (2018) Insertion of a Double Pigtail Ureteral ... Online publication date: 1-Sep-1994.Benoit G, Alexandre L, Moukarzel M, Yataghene Y, Charpentier B and Jardin A (2018) Percutaneous Antegrade Dilation ...
Tópico(s): Ureteral procedures and complications
1982 - Lippincott Williams & Wilkins | The Journal of Urology
Oscar Salvatierra, Cornelius Olcott, W Amend, Kent C. Cochrum, Nicholas J. Feduska,
... date: 1-Jun-2001.Benoit G, Blanchet P, Alexandre L and Charpentier B (2018) Insertion of a Double Pigtail Ureteral ... Online publication date: 1-Jan-1995.Benoit G, Alexandre L, Moukarzel M, Yataghene Y, Charpentier B and Jardin A (2018) Percutaneous Antegrade Dilation ...
Tópico(s): Renal Transplantation Outcomes and Treatments
1977 - Lippincott Williams & Wilkins | The Journal of Urology
E. Kangni-Foli, Stéphane Poyet, P. Le Bescop, Thibault Charpentier, Fabien Bernachy‐Barbe, Alexandre Dauzères, Emilie L’Hôpital, Jean‐Baptiste d'Espinose de Lacaillerie,
This study explored the reactive processes of atmospheric carbonation and the consequences with respect to cementitious materials. Two model pastes were used: hydrated C3S (including C-S-H and portlandite) and a paste prepared by hydrating a blend of C3S and nanosilica (including C-S-H only). The two pastes were carbonated under accelerated conditions in the laboratory. The resulting mineralogical assemblage was examined using X-ray diffraction, thermogravimetric analysis and nuclear magnetic resonance. ...
Tópico(s): Innovative concrete reinforcement materials
2021 - Elsevier BV | Cement and Concrete Research
Clara Vigneron, Julien Charpentier, Sandrine Valade, Jérôme Alexandre, S. Chelabi, Lola‐Jade Palmieri, Nathalie Franck, Valérie Laurence, Jean-Paul Mira, Matthieu Jamme, Frédéric Pène,
Major therapeutic advances including immunotherapy and targeted therapies have been changing the face of oncology and resulted in improved prognosis as well as in new toxic complications. The aim of this study is to appraise the trends in intensive care unit (ICU) admissions and outcomes of critically ill patients with solid malignancies. We performed a retrospective single-centre study over a 12-year period (2007-2018) including adult patients with solid malignancies requiring unplanned ICU admission. ...
Tópico(s): Neutropenia and Cancer Infections
2021 - Springer Nature | Annals of Intensive Care
Céline Monard, Jonathan Pehlivan, Gabriel Auger, Sophie Alviset, Alexy Tran‐Dinh, Paul Duquaire, Nabil Gastli, Camille d’Humières, Adel Maamar, A. Boibieux, M. Baldeyrou, Julien Loubinoux, Olivier Dauwalder, Vincent Cattoir, Laurence Armand-Lefèvre, Solen Kernéis, Agathe Becker, Julien Charpentier, Julien Textoris, Claude-Alexandre Gustave, Grégory Destras, François Vandenesch, Bruno Lina, Jean‐Sébastien Casalegno, Manon Lejeune, Philippe Montravers, Claire Poyart, H. Tête, Jean‐François Timsit, Thomas Uberti,
Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult patients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-acquired pneumonia (VAP).This retrospective multicenter study was conducted in four French university ...
Tópico(s): Nosocomial Infections in ICU
2020 - BioMed Central | Critical Care
Benoît Visseaux, Charlotte Charpentier, Margarita Hurtado‐Nedelec, Alexandre Storto, Romain Antoine, Gilles Peytavin, Florence Damond, Sophie Matheron, Françoise Brun‐Vézinet, Diane Descamps,
HIV-2 is naturally resistant to nonnucleoside reverse transcriptase inhibitors, to a fusion inhibitor, and to some of the protease inhibitors. Maraviroc is the first drug of the new anti-CCR5 drug class and is effective only on CCR5-tropic (R5) HIV-1. No previous studies concerning HIV-2 susceptibility to maraviroc have been reported yet. We developed a phenotypic maraviroc susceptibility test using a peripheral blood mononuclear cell (PBMC) model. We analyzed the maraviroc susceptibility of 13 R5 ...
Tópico(s): HIV/AIDS Research and Interventions
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Michèle Guilloux-Bénatier, David Chassagne, Hervé Alexandre, Claudine Charpentier, Michel Feuillat,
<p style="text-align: justify;"><em>Brettanomyces</em>, a contaminant yeast, is relatively common in wines and mainly in red wines during barrel aging. The results presented here relate to the effects of yeast lees autolysis on the growth of <em>Brettanomyces</em>. Experiments were realised in a culture medium after alcoholic fermentation, in a hydroalcoholic wine-like solution and in a red wine. <em>Brettanomyces</em> was inoculated at low level : 10<sup>2</ ...
Tópico(s): Fungal Biology and Applications
2001 - ADERA | OENO One
Hervé Alexandre, C. Charpentier,
Recently a number of studies have focused on the factors responsible for the occurrence of stuck and sluggish fermentations. Results from these studies indicate that together with nutritional deficiencies and inhibitory substances, technological practices could lead to such situations. This review explains, from a biochemical point of view, the influence of nutritional deficiencies, inhibitory substances and technological practices on yeast cell development and physiology and the fermentation process.
Tópico(s): Biochemical and biochemical processes
1998 - Springer Science+Business Media | Journal of Industrial Microbiology & Biotechnology
Stéphane Boivin, Michel Feuillat, Hervié Alexandre, Claudine Charpentier,
Mannoproteins have a great technological importance such as improvement of proteic and tartaric acid stability or the stimulation of lactic acid bacteria, but their production in wine is still poorly understood. The influence of grape juice turbidity on Saccharomyces cerevisiae cell wall characteristics was studied. Grape juice insoluble particles and colloids were shown to have no influence on yeast cell wall porosity during the lag time but their absence led to increased yeast cell wall porosity ...
Tópico(s): Polysaccharides and Plant Cell Walls
1998 - American Society for Enology and Viticulture | American Journal of Enology and Viticulture