Hiddo J.L. Heerspink, Jai Radhakrishnan, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Ulysses Diva, Jula K. Inrig, Radko Komers, Alex Mercer, Irene L. Noronha, Michelle N. Rheault, William E. Rote, Brad H. Rovin, Howard Trachtman, Hernán Trimarchi, Muh Geot Wong, Vlado Perkovic, Eric Alarmartine, Jonathan Barratt, Dong‐Wan Chae, Lucia Del Vecchio, Jürgen Floege, Shang‐Jyh Hwang, Bojan Jelaković, Bart Maes, Robert Małecki, Marius Miglinas, Fernando Nolasco, M Praga, Kannaiyan S Rabindranath, Mai Rosenberg, Brad H. Rovin, Sydney C.W. Tang, Vladmir Tesar, Muh Geot Wong, Bhadran Bose, Muralikrishna Gangadharan, Stephen P. McDonald, Chen Au Peh, Sadia Jahan, Chii Yeap, Philip A. Clayton, Georgina Irish, Nikhil Thyagarajan, Peter Hollett, Rathika Krishnasamy, Robert J. Carroll, Shilpanjali Jesudason, Susan Crail, Toby Coates, Jane Waugh, Euan Noble, Kumaradevan Mahadevan, Victoria Campbell, Tania Salehi, Wai H. Lim, Neil Boudville, Aron Chakera, Doris Chan, Anoushka Krishnan, Yusuf Eqbal, Alastair Gillies, Eswari Vilayur, Thida Maung Myint, Nicholas A. Gray, Jane Waugh, Euan Noble, Melissa S Cheetham, Yusuf Eqbal, Peter Hollett, Rathika Krishnasamy, Kumaradevan Mahadevan, Victoria Campbell, Carol A. Pollock, Bruce A. Cooper, Amanda Mather, Sarah Roxburgh, Yvonne Shen, Stefanie Stangenberg, Amanda Siriwardana, Emma O’Lone, Susan Wan, Brendon L. Neuen, Jeffrey Ha, Dana Kim, Lauren Heath, Arunima Jain, Elaine Phua, Li Yan, M. W. Gallagher, Meg Jardine, Angus Ritchie, Mona Razavian, Celine Foote, Roger Wyndham, Shaundeep Sen, Zoltán Endre, Jonathan Erlich, Mangalee Fernando, Kenneth Yong, Grant Luxton, Sradha Kotwal, Simon D. Roger, Vidu Wijeratne, David Packham, Ian Fraser, Bert Vandewiele, Margo Laute, Wim Lemahieu, Sofie Jamar, Sara Ombelet, Gert Meeus, Marc Decupere, Olivier P. Schockaert, Peter Doubel, Liesbeth Viaene, Luc Radermacher, Catherine Masset, Martial Moonen, Éric Firre, Martina Milicevic, Xavier Warling, An Vanacker, Thomas Malfait, Ivan Durlen, Ivica Horvatić, Ana Šavuk, Lana Gellineo, Sandra Karanović, Živka Dika, Djuro Plavljanic, Ivana Mikačić, Dubravka Trajbar Kentric, Dunja Barisic, Marija Stanković, Karolina Majstorović Barać, Ivan Kruljac, Draško Pavlović, Martin Drinković, Ingrid Prkačin, Jerko Barbić, Zvonimir Sitaš, Dunja Vujčić, Ivan Rychlík, Anna Benesova, Klara Drinovska, Karolína Krátká, Dita Maixnerová, Madis Ilmoja, Kristin Unt, Kadri Lilienthal, Asta Auerbach, Liisi Leis, Julia Piel, Annika Adoberg, Külli Kõlvald, Kristi Veermae, Kadri Telling, Elviira Seppet, Jana Uhlinova, Philippe Zaoui, Pierre‐Louis Carron, Ingrid Masson, M. Dinic, Damien Thibaudin, C Broyet, Nicolas Maillard, Hesham Mohey, Christophe Mariat, Guillaume Claisse, É. Alamartine, Bertrand Dussol, Stéphane Burtey, Noemie Chiche-Jourde, Jean‐Emmanuel Serre, Guillaume Jeantet, Leïla Chénine, Anne Blanchard, Stéphane Roueff, Éric Thervet, David Fouassier, Alexandre Buffet, Marine Livrozet, Roxane Gaïsset, Alexandre Karras, Anne-Elisabeth Heng, Cyril Garrouste, Carole Philipponnet, C. Nicolò, Alba Atenza, Camille Lanaret, Clarisse Grèze, Valentin Mayet, Clément Dumond, Yahsou Delmas, Christian Combe, Claire Rigothier, Laure Burguet, Aurore Labat, Simon Mucha, V. de Précigout, Thomas Weinreich, Helmut Reichel, Diliana Draganova, Lothar Wolf, Bernd Hohenstein, Sven Heinrichs, Simone Kulka, Sebahat Şat, Lea Weiland, Thilo Krueger, Günter Wolf, Christiane Kettner, Mandy Schlosser, Johann Konstantin Herfurth, Annegret Koch, Martin Busch, Stephan Christian Werth, Martin Nitschke, Figen Cakiroglu, Franziska Sarnow, Lisa Schulz, Stefan M. Weiner, Nikolaus Wirtz, Eric Koester, Marcus J. Moeller, Eleni Stamellou, Silja K. Sanden, Hans Schmidt-Guertler, Wanja Bernhardt, Margret Patecki, Georg Schlieper, Kevin Schulte, Annette Girardet, Ulrich Kunzendorf, Lorraine Pui Yuen Kwan, Maggie Ming Yee Mok, Gary C.W. Chan, Mingyao Ma, Davina Ngoi Wah Lie, Anthony Ting Pong Chan, Cheuk‐Chun Szeto, Jack Kit‐Chung Ng, Siu Fai Cheung, Tak Tai Andrew Yue, Samuel Fung, Hon Tang, Ka Fai Yim, Wai Ping Law, Yick Hei Wong, Chi Kwan Darwin Lam, Sze Ho Sunny Wong, Carmelita Marcantoni, Roberta Aliotta, Francesca Deodato, Gemma Patella, Nicolino Comi, Caterina Vita, Nazareno Carullo, Davide Bolignano, Michela Musolino, Matias Trillini, Norberto Perico, Giuseppe Remuzzi, Erica Daina, Luigi Biancone, Loredana Colla, Manuel Burdese, C Cogno, Elena Boaglio, Isabella Abbasciano, Carlotta Federica Zizzi, Paolo Randone, Pietro Napodano, Anna Ricchiuto, Matthias Cassia, Simone Accarino, Mario Cozzolino, Rocco Baccaro, Stefano Costanzi, Federica Di Maio, Maria Arena, Federica Urciuolo, Sarà Vigano, Andrea Cavalli, Monica Limardo, M Bordoli, Serena Ponti, Selena Longhi, Andrea Solazzo, Francesco Giaroni, Gabriele Donati, Massimo Torreggiani, Davide Catucci, Marco Colucci, Vittoria Esposito,
Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety.PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 ...
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Brad H. Rovin, Jonathan Barratt, Hiddo J.L. Heerspink, Charles E. Alpers, Stewart Bieler, Dong-Wan Chae, Ulysses Diva, Jürgen Floege, Loreto Gesualdo, Jula K. Inrig, Donald E. Kohan, Radko Komers, Laura Kooienga, Richard A. Lafayette, Bart Maes, Robert Małecki, Alex Mercer, Irene L. Noronha, Se Won Oh, Chen Au Peh, Manuel Praga, Priscila Preciado, Jai Radhakrishnan, Michelle N. Rheault, William E. Rote, Sydney C.W. Tang, Vladimı́r Tesař, Howard Trachtman, Hernán Trimarchi, James A. Tumlin, Muh Geot Wong, Vlado Perkovic, Isabella Abbasciano, Catarina Abrantes, Simone Accarino, Sharon G. Adler, Annika Adoberg, Rouzbeh Afsari, Syeda B. Ahmad, Jafar Ahmed, Wooin Ahn, Bamidele Ajayi, Dariusz Aksamit, Saif Al‐Chalabi, É. Alamartine, Bassam Alchi, Mohammad Ali, Roberta Aliotta, Salem Almaani, Catarina Almeida, Edgar Almeida, Francisco de la Prada Alvarez, Patrícia Marques‐Alves, Francesca Annese, Gerald B. Appel, Alberto Ortíz, Maria Arena, Marta Calvo Arevalo, Dariush Arfaania, Carlos Arias, Emma Calatayud Aristoy, Eglė Ašakienė, Sarah Ashley, Ali Assefi, Alba Atenza, Asta Auerbach, Hanna Augustyniak‐Bartosik, M Avella, Jonathan Ayling-Smith, Isabelle Ayoub, Christine Ayvazyan, Rocco Baccaro, Asha Bailey, Bruce Baker, Saravanan Balamuthusamy, José Ballarín, Rui Barata, Jerko Barbić, Dunja Barisic, Jonathan Barratt, José C. Barreto, Clara Barrios, Mirco Belingheri, Anna Benesova, Ana Ávila Bernabéu, Wanja Bernhardt, Shamik Bhadra, Luigi Biancone, Anne Blanchard, Elena Boaglio, Davide Bolignano, Andrew S. Bomback, Gustavo Andres Useche Bonilla, M Bordoli, Bhadran Bose, Neil Boudville, Donald Brandon, Donald Brandon, Karen Brown, C Broyet, Thomas Bucknall, Alexandre Buffet, Inga Arūnė Bumblytė, Manuel Burdese, Natalia Allende Burgos, Natalia Allende Burgos, Laure Burguet, Stéphane Burtey, Martin Busch, Figen Cakiroglu, Victoria Campbell, Pietro A. Canetta, Flavia Capaccio, Juan Carbonell, Filipa Cardoso, Clara García Carro, Robert J. Carroll, Pierre‐Louis Carron, Nazareno Carullo, Matthias Cassia, Dawn J. Caster, Belen Vizcaino Castillo, Davide Catucci, Andrea Cavalli, Dong-Wan Chae, Aron Chakera, Doris Chan, Gary C.W. Chan, Anthony Ting Pong Chan, Lai Wan Chan, Jae Hyun Chang, Ming-Shan Chang, Fiona A. Chapman, Chaim Charytan, Asghar Chaudhry, Melissa S Cheetham, Cheng‐Hsu Chen, Hsin-Yu Chen, Chien‐Liang Chen, Hung‐Yuan Chen, Hung‐Chun Chen, Leïla Chénine, Siu Fai Cheung, Chee Kay Cheung, Noemie Chiche-Jourde, Hsien‐Fu Chiu, Yen‐Ling Chiu, Yi‐Wen Chiu, Ian Chiu, Hoon Young Choi, Kang‐Ju Chou, Paramit Chowdhury, Pradip Chowdhury, Constantina Chrysochou, Chukwuma Chukwu, Ka Yeong Chun, Wookyung Chung, Dominik Cieniawski, Guillaume Claisse, Philip A. Clayton, Catalina Martín Cleary, Nisha Clement, Toby Coates, C Cogno, Loredana Colla, Michael Collins, Marco Colucci, Christian Combe, Nicolino Comi, Roderick Comunale, Gabriel Contreras, Bruce A. Cooper, Gaia Coppock, Ana Cortesão Costa, Stefano Costanzi, Mario Cozzolino, Susan Crail, Liliana Cunha, Elizabeth Curry, Tiane Dai, Erica Daina, Sam Daneshvari, Indranil Dasgupta, Louise DaSilva, Robert M. Davidson, Aine Maire De Bhailis, V. de Précigout, Marc Decupere, Yahsou Delmas, Francesca Deodato, Neeraj Dhaun, Ajay Dhaygude, Ranjit Dhelaria, Federica Di Maio, María Ángeles Goicoechea Diezhandino, Živka Dika, M. Dinic, Ian Dittmer, Mirela Dobre, Gabriel Doctor, Gabriele Donati, Peter Doubel, Nicole Douthit, Diliana Draganova, Yelena Drexler, Martin Drinković, Klara Drinovska, Caroline Dudreuilh, Clément Dumond, Ivan Durlen, Bertrand Dussol, Montserrat Díaz-Encarnación, Zoltán Endre, Jorge Enrique, Yusuf Eqbal, Jonathan Erlich, Vittoria Esposito, Ciro Esposito, Faisal Fakih, Hua‐Chang Fang, Ana Farinha, Aaron Fearday, Joana Felgueiras, Elzbieta Felicjanczuk, João Carlos Fernandes, Sara Fernandes, Adriana Fernandes, Jose Luño Fernandez, Víctor Fernández, Mangalee Fernando, Ana Figueiredo, Éric Firre, Jürgen Floege, Oliver Floßmann, Lauren Floyd, Nuno Moreira Fonseca, José Nuno Fonseca, Celine Foote, Suzanne Forbes, Ángel Blasco Forcén, Alessia Fornoni, David Fouassier, Ian Fraser, Samuel Fung, Mónica Furlano, Teresa Furtado, Rajdeep Gadh, Roxane Gaïsset, M. W. Gallagher, Joana Gameiro, Muralikrishna Gangadharan, Fabiola Alonso García, Olga Gracia Garcia, Gunjan Garg, Cyril Garrouste, Archana Gautam, Abdallah S. Geara, Colin Geddes, Lana Gellineo, Michael J. Germain, Loreto Gesualdo, Farid Ghalli, Francesco Giaroni, Harold Giles, Alastair Gillies, Ana Vilar Gimeno, Annette Girardet, Jeffrey Glaze, Tze Liang Goh, Mário Góis, Christopher Goldsmith, Elena Gomá-Garcés, Ana Marta Gomes, Luis Pedro Falcao Goncalves, Sara Gonçalves, Julita Gontarek-Kacprzak, Carlos González, Arun Gopu, Nayan Gowda, Nicholas A. Gray, Barbara Greco, Heather Green, Clarisse Grèze, Siân Griffin, Secundino Cigarrán, Úrsula Verdalles Guzmán, Jeffrey Ha, Amanda K. Hall, Patrick Hamilton, Seung Hyeok Han, Robert Haws, Ashik Hayat, Lauren Heath, Sven Heinrichs, Andrew Henderson, Amy Henderson,
Background Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis. Methods PROTECT, a double-blind, randomised, active- ...
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